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hypothermia gastric mucosa

Yan Wang, Jian Song, Yuhong Liu, Yaqiang Li, Zhengxin Liu
BACKGROUND The purpose of this study was to determine the effect of mild hypothermia therapy on gastric mucosa after cardiopulmonary resuscitation (CPR) and the underlying mechanism. MATERIAL AND METHODS Ventricular fibrillation was induced in pigs. After CPR, the surviving pigs were divided into mild hypothermia-treated and control groups. The changes in vital signs and hemodynamic parameters were monitored before cardiac arrest and at intervals of 0.5, 1, 2, 4, 6, 12, and 24 h after restoration of spontaneous circulation...
October 3, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Daniel Siegl, Emily F Midura, Thorsten Annecke, Peter Conzen, Charles C Caldwell, Johannes Tschoep
INTRODUCTION: It is well established that obesity-related hormones can have modulatory effects associated with the immune response. Ghrelin, a hormone mainly derived from endocrine cells of the gastric mucosa, regulates appetite, energy expenditure and body weight counteracting leptin, a hormone mainly derived from adipocytes. Additionally, receptors of both have been detected on immune cells and demonstrated an immune regulatory function during sepsis. METHODS: In the present study, the effect of peripheral ghrelin administration on early immune response and survival was investigated with lean mice and mice with diet-induced obesity using cecal ligation and puncture to induce sepsis...
2015: PloS One
Fiona M Bright, Calle Winskog, Michael Tsokos, Melissa Walker, Roger W Byard
A review of hypothermic deaths was undertaken using cases from the Charité University, Berlin, Germany and Forensic Science South Australia, Australia. There were 16 cases from Berlin (age range 38-96 years; average 68 years; M:F = 13:3) Wischnewski spots were present in all 16 cases (100%), skin discolouration in nine (56%), and acute pancreatitis and muscle haemorrhage in one case each (6%). There were 62 Australian cases (age range 30-89 years; average 67 years; M:F = 13:18). Wischnewski spots were present in 57 (92%), skin discolouration in seven (11%), vacuolization of renal cells in six (10%), and acute pancreatitis in one (2%)...
February 2014: Journal of Forensic and Legal Medicine
Christian Vollmer, Ingo Schwartges, Meike Swertz, Christopher Beck, Inge Bauer, Olaf Picker
Hypothermia is known to improve tissue function in different organs during physiological and pathological conditions. The aim of this study was to evaluate the effects of hypothermia on oral and gastric mucosal microvascular oxygenation (μHbO2) and perfusion (μflow) under physiological and hemorrhagic conditions. Five dogs were repeatedly anesthetized. All animals underwent each experimental protocol (randomized cross-over design): hypothermia (34°C), hypothermia during hemorrhage, normothermia, and normothermia during hemorrhage...
2013: Oxidative Medicine and Cellular Longevity
Vladimir Zivković, Slobodan Nikolić
We present a case of two brothers who died simultaneously, where their deaths could be considered to be a form of a Philemon and Baucis death; they also showed signs of Diogenes syndrome and syllogomania. The two brothers had been living in a socially isolated state and had not left their flat for months. They were found dead during the winter, in a flat with no heating. Taking the poor condition of the flat into consideration, it can be assumed that a draught existed and, therefore, the bodies were exposed to convection, that is, ventilation and low humidity, which is what caused partial mummification to the exposed areas of the body...
July 2014: Medicine, Science, and the Law
Xin Zhao, Shijun Yang, Wentong Zhang, Chengzhe Zu, Binghua Tang, Baochun Zhang, Guozhang Li, Lin Su, Dayong Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Fuzi-Lizhong pill (FLZ) is a traditional Chinese medicine for treating patients with Spleen Yang deficient syndrome. Ghrelin, a peptide with 28 amino acid residues, plays multiple roles in thermogenesis. This study aims to explore FLZ regulating ghrelin to compensate hypothermia in rats with hypothyroid and indigestion. MATERIALS AND METHODS: In litter-matched rats, hypothermia was developed with both thyroidectomy at d1 and interscapular brown adipose (IBA) removal at d42, indigestion was induced with both high fat diet and fasting-feeding cycle from d56; the littermates with hypothermia and indigestion were administrated with FLZ from d70...
October 7, 2013: Journal of Ethnopharmacology
Fiona Bright, Calle Winskog, Melissa Walker, Roger W Byard
Hypothermic fatalities in humans are characterized by a range of often subtle pathological findings that typically include superficial erosive gastritis (Wischnewski spots). Experimental studies have been successfully performed using animal models to replicate this finding, however study animals have inevitably been subjected to a variety of additional stressors including food deprivation, restraint and partial immersion in water while conscious. As it is recognised that stress on its own may cause superficial erosive gastritis, a model has been developed to enable the study of the effects of hypothermia in isolation...
August 2013: Journal of Forensic and Legal Medicine
Anna Salwa, Magdalena Skrzela
The objective of this study was to determine the prevalence of macroscopic morphological lesions typical of death from hypothermia and to show their correlation with such factors as blood alcohol level, air temperature, age and number of layers of clothing. The analysis was performed based on protocols of autopsies performed in the years 1995-2009. The sample comprised 124 persons with a diagnosis of death from hypothermia. The results showed no correlation between the number of gastric erosions and the level of alcohol in blood or urine...
April 2012: Archiwum Medycyny Sa̧dowej i Kryminologii
Yi Lu, Shuo Wang, Chun-sheng Li
BACKGROUND: During cardiac arrest, the gastrointestinal tract is sensitive to ischemia. Protection of the gastrointestinal tract is a critical factor in determining prognosis following cardiopulmonary resuscitation (CPR). This study seeks to determine the extent of gastrointestinal tract injury and the potential protective effect of inducing hypothermia following a porcine cardiac arrest model and CPR. METHODS: Ventricular fibrillation was induced by programmed electrical stimulation in 16 male domestic pigs (n = 8 per group)...
December 2012: Chinese Medical Journal
Xin Zhao, Yong Wang, Shijun Yang, Wentong Zhang, Chengzhe Zu, Taotao Zhang, Binghua Tang, Baochun Zhang, Guozhang Li, Bo Deng, Dayong Cai
This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular brown adipose (IBA) removal with standard diet, Fat-diet did IBA removal with fat-diet, and ALZ did IBA removal and fat-diet with 4.536 g/kg/d ALZ. The potency of adaptive thermogenesis, ghrelin levels in plasma or gastric mucosa, thyroid hormones and metabolite in sera, expression of ghrelin mRNA, and protein in gastric mucous membrane were determined...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
(no author information available yet)
The article describes the features of formation of "spots of Vishnevsky", in general hypothermia. It is proved that the wedge shape of hemorrhages in the gastric mucosa caused by swelling and discrepancy of the paries of stomach pits with the filling of forming wedge-shaped cavity with blood from the arrosive capillaries. It is noted that the dynamics of accumulation of PAS-positive material in the gastric pits in the gastric mucosa in case of total of hypothermia is directly dependent on the growth of intracellular acidosis and disintegration of plasmolemma of parietal cells...
May 2012: Voenno-medit︠s︡inskiĭ Zhurnal
Fiona Bright, Calle Winskog, Roger W Byard
No abstract text is available yet for this article.
March 2013: Forensic Science, Medicine, and Pathology
Ali Riza Karaci, Ahmet Sasmazel, Numan Ali Aydemir, Turkay Saritas, Bugra Harmandar, Zeliha Tuncel, Akif Undar
The aim of this study is to evaluate gastric mucosal oxygenation together with whole-body oxygen changes in infants undergoing congenital heart surgery with cardiopulmonary bypass (CPB) procedure and the use of either pulsatile or nonpulsatile mode of perfusion with normothermia and pulsatile or nonpulsatile moderate hypothermia. Sixty infants undergoing congenital cardiac surgery were randomized into four groups as: nonpulsatile normothermia CPB (NNCPB, n = 15), pulsatile normothermia CPB (PNCPB, n = 15), nonpulsatile moderate hypothermia CPB (NHCPB, n = 15), and pulsatile moderate hypothermia CPB (PHCPB, n = 15) groups...
November 2011: Artificial Organs
J Fazakas, A Doros, A Smudla, S Tóth, B Nemes, L Kóbori
INTRODUCTION: Hepatic diseases decrease the liver's involvement in thermoregulation. Removal of the liver during transplantation increases the incidence of hypothermia during the surgery. The aims of the present study were to analyze the hemodynamic changes among hypothermic liver transplantations and to determine its relationship to postoperative complications. METHODS: Conventional and volumetric hemodynamic monitoring and intramucosal pH measurements were performed during 54 liver transplantations...
May 2011: Transplantation Proceedings
Lasse Pakanen, Marja-Leena Kortelainen, Terttu Särkioja, Katja Porvari
The significance of urinary catecholamines and small gastric mucosal bleedings, Wischnewsky's spots, in postmortem diagnosis of hypothermia deaths was evaluated. Autopsy cases (n=358) were divided into hypothermia, suspected hypothermia, and control groups. The catecholamine levels did not correlate with the length of the postmortem period. The adrenaline to noradrenaline ratio was most effective in detecting hypothermia (68.9% sensitivity, 78.1% specificity). The median adrenaline concentrations were significantly higher in hypothermia than in control groups...
September 2011: Journal of Forensic Sciences
Alon Krispin, Kounstantin Zaitsev, Jehuda Hiss
Hypothermia is a rare cause of death in Israel, and usually occurs among risk groups such as elderly people, homeless persons, psychiatric patients and persons who function in cold environments or are unintentionally exposed to such conditions. Death due to hypothermia generally occurs in extremely cold conditions, although ambient temperatures of 15-20 degrees C can also be lethal. The phenomenon of paradoxical undressing that characterizes death due to hypothermia rather occurs in moderate ambient temperatures, and takes place when the victim is in extremis...
March 2011: Harefuah
Elisabeth E Turk
Hypothermia refers to a situation where there is a drop in body core temperature below 35 degrees C. It is a potentially fatal condition. In forensic medicine and pathology, cases of hypothermia often pose a special challenge to experts because of their complex nature, and the often absent or nonspecific nature of morphological findings. The scene of the incident may raise suspicions of a crime initially, due to phenomena such as terminal burrowing behavior and paradoxical undressing. An element of hypothermia often contributes to the cause of death in drug- and alcohol-related fatalities, in the homeless, in immersion deaths, in accidents and in cases of abuse or neglect, making the condition extremely relevant to forensic medical specialists...
June 2010: Forensic Science, Medicine, and Pathology
Marija Jakubeniene, Algimantas Irnius, Gregoire Abi Chaker, Jonas Mindaugas Paliulis, Antanas Bechelis
The identification of hypothermia as cause of the death was always quite problematic in the field of forensic medicine. The aim of the present study was to verify the determination of calcium content in post-mortem liver, heart, and skeletal muscle samples as the biochemical marker defining hypothermia as the cause of death. The study involved 43 autopsy cases in which the circumstances of death indicated the effects of overcooling. The control group consisted of material collected from the corpses of 30 persons who were not exposed to low temperatures but died due to technical injuries (n=5), asphyxia (n=6), intoxication with ethanol and other substances (n=8), and acute myocardial infarction/ischemia (n=11)...
September 10, 2009: Forensic Science International
O V Bohdanova, L I Kot, K V Lavrova, L I Ostapchenko
Acute cold stress caused lesions of gastric mucosa as a result of its attack by active oxygen and nitrogen compounds. The tissue regeneration is regulated by a cascade of tyrosine protein kinases. Gastric ulceration leads to a decrease in activity of tyrosine protein kinases and phosphatases, following by fall in phosphotyrosine content in proteins of plasma membranes of gastric mucosa cells. No changes in superoxide dismutase activity, slight increase in catalase activity, inhibition of glutathione peroxydase, significant increase in OH* content and decrease in zinc level were observed in the gastric mucosa cells of stressed rats...
September 2008: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
Li-Xia Lou, Bin Geng, Jun-Bao Du, Chao-Shu Tang
1. Hydrogen sulphide (H(2)S) acts as a gaseous cellular messenger and has recently been reported to induce a suspended animation-like state in mice. The aim of the present study was to investigate the protective role of H(2)S exposure in stress gastric ulcer. 2. In the present study, we used a rat model of water immersion and restraint stress (WRS) to induce the typical stress disease, namely stress gastric ulcer. Rats were treated with WRS for 4 h, with or without pre-exposure to H(2)S (160 p.p.m. H(2)S for 2...
February 2008: Clinical and Experimental Pharmacology & Physiology
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