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https://www.readbyqxmd.com/read/28985892/laparoscopic-donor-nephrectomy-a-single-institution-minimally-invasive-general-surgeon-experience-1999-2013
#1
Benjamin Raber, Matthew Westmoreland, David Arnold, Butch Derek, Richard Lueking, Grace Lassiter, Elizabeth Nguyen
BACKGROUND: Laparoscopic donor nephrectomy (LDN) is the standard of care for donor nephrectomies. No large series reports have been published detailing the LDN experience of minimally invasive general surgeons. METHODS: A retrospective review of 526 LDNs performed by MIS general surgeons at Baylor University Medical Center between 1999 and 2013. Complications were graded on the Clavien scale. The learning curve was determined by procedure time. RESULTS: The complication rate was 3...
September 29, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28967825/evaluation-of-drug-content-potency-for-compounded-and-fda-approved-formulations-of-doxycycline-on-receipt-and-after-21-days-of-storage
#2
Kate KuKanich, Butch KuKanich, Tanner Slead, Matt Warner
OBJECTIVE To determine drug content (potency) of compounded doxycycline formulations for veterinary use and of US FDA-approved doxycycline formulations for human use < 24 hours after receipt (day 1) and after 21 days of storage under recommended conditions (day 21). DESIGN Evaluation study. SAMPLE FDA-approved doxycycline tablets (100 mg), capsules (100 mg), and liquid suspension (10 mg/mL) and compounded doxycycline formulations from 3 pharmacies (tablets [25, 100, and 150 mg; 1 product/source], chews [100 mg; 1 product/source], and liquid suspensions or solution [6 mg/mL {2 sources} and 50 mg/mL {1 source}])...
October 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28903825/pharmacokinetics-of-single-dose-subcutaneous-meloxicam-injections-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#3
Thomas L Wright, David Eshar, Christina McCullough, Matt Warner, Butch Kukanich
This study evaluated the pharmacokinetic profile of a single dose of meloxicam (1.0 mg/kg) administered subcutaneously (n = 6) or intravenously (n = 2) to black-tailed prairie dogs (Cynomys ludovicianus). Blood was collected immediately before (time 0) and at 0.5, 1, 2, 4, 8, 12 and 24 h after drug administration. Plasma meloxicam concentrations were quantified with HPLC-mass spectrometry, and noncompartmental pharmacokinetic analysis was performed. The peak plasma concentrations, time to peak plasma concentration, and terminal half-life of meloxicam after subcutaneous administration (median [minimum-maximum]) were 4...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28749301/pilot-study-pharmacokinetics-of-oral-and-topical-moxidectin-in-the-reticulated-giraffe-giraffa-camelopardalis
#4
Gary West, Elizabeth E Hammond, Butch KuKanich
The objective of this study was to obtain an estimate of the pharmacokinetic parameters of moxidectin administered at a dosage of 1 mg/kg orally and topically to healthy adult giraffe ( Giraffa camelopardalis ). The maximum plasma concentration (CMAX) of moxidectin after oral and topical administration was 69.2 ± 4.6 and 18.6 ± 16.1 ng/ml (P = 0.045), respectively. The areas under the plasma curve (AUC), a measure of total drug exposure, was 532.0 ± 232.3 and 209.1 ± 180.0 day*ng/ml (P = 0.308) for the oral and topical administrations, respectively...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28671321/the-influence-of-small-doses-of-ethanol-on-the-urinary-testosterone-to-epitestosterone-ratio-in-men-and-women
#5
Sami Albeiroti, Brian D Ahrens, Timofei Sobolevskii, Anthony W Butch
Endogenous steroid use can increase urinary testosterone/epitestosterone (T/E) values. In addition, ethanol in amounts >0.5 g per kg of body weight (g/kg) can also increase T/E values. However, the effect of smaller doses of ethanol on T/E values is unknown. The influence of 0.2 and 0.4 g/kg of ethanol on baseline T/E values in 20 men and 20 women with low and high baseline T/E values was investigated and correlated with ethyl glucuronide (EtG) and ethyl sulfate (EtS) concentrations. T/E values for 7 of the women were excluded from the study because of undetectable T concentrations or for other reasons...
July 3, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28609023/relations-of-sex-hormone-levels-to-leukocyte-telomere-length-in-black-hispanic-and-asian-pacific-islander-postmenopausal-women
#6
Yan Song, Michele Cho, Kathleen Brennan, Brian H Chen, Yiqing Song, JoAnn E Manson, Andrea L Hevener, Nai-Chieh Y You, Anthony W Butch, Simin Liu
BACKGROUND: Sex hormones may play important roles in sex-specific biological aging. We specifically examined the associations between circulating concentrations of sex hormones and leukocyte telomere length (TL). METHODS: We conducted a cross-sectional study of 1124 black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Concentrations of estradiol and testosterone were measured using electrochemiluminescence immunoassays...
June 13, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28586221/the-structure-activity-relationship-of-a-tetrahydroisoquinoline-class-of-n-methyl-d-aspartate-receptor-modulators-that-potentiates-glun2b-containing-n-methyl-d-aspartate-receptors
#7
Katie L Strong, Matthew P Epplin, John Bacsa, Christopher J Butch, Pieter B Burger, David S Menaldino, Stephen F Traynelis, Dennis C Liotta
We have identified a series of positive allosteric NMDA receptor (NMDAR) modulators derived from a known class of GluN2C/D-selective tetrahydroisoquinoline analogues that includes CIQ. The prototypical compound of this series contains a single isopropoxy moiety in place of the two methoxy substituents present in CIQ. Modifications of this isopropoxy-containing scaffold led to the identification of analogues with enhanced activity at the GluN2B subunit. We identified molecules that potentiate the response of GluN2B/GluN2C/GluN2D, GluN2B/GluN2C, and GluN2C/GluN2D-containing NMDARs to maximally effective concentrations of agonist...
July 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28541147/pharmacokinetics-of-cefazolin-for-prophylactic-administration-to-dogs
#8
COMPARATIVE STUDY
Omar J Gonzalez, Walter C Renberg, James K Roush, Butch KuKanich, Matt Warner
OBJECTIVE To evaluate pharmacokinetics of cefazolin after IV injection of cefazolin (22 mg/kg) and after simultaneous IV and IM injections of cefazolin (total dose, 44 mg/kg) to dogs. ANIMALS 12 adult Beagles. PROCEDURES Dogs (6/group) were assigned to receive a single injection of cefazolin (IV group; 22 mg/kg, IV) or simultaneous injections (IV + IM group; 22 mg/kg, IV, and 22 mg/kg, IM). Interstitial fluid was collected over a 5-hour period by use of ultrafiltration probes for pharmacokinetic analysis. RESULTS Mean cefazolin concentration in the interstitial fluid at 1, 1...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28363047/pharmacokinetics-of-a-single-dose-of-oral-and-subcutaneous-enrofloxacin-in-caribbean-flamingos-phoenicopterus-ruber-ruber
#9
Melissa R Nau, James W Carpenter, Butch KuKanich, Matt Warner
Enrofloxacin is a fluoroquinolone antimicrobial that is widely used in veterinary medicine because of its bactericidal activity and safety in a broad range of species. Caribbean flamingos, a member of the order Phoenicopteriformes, are popular in zoological collections and suffer from a variety of conditions that can result from or lead to bacterial infection. In this study, two groups of 7 adult captive Caribbean flamingos received a single dose of 15 mg/kg enrofloxacin, administered either orally or subcutaneously...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28339888/influence-of-low-and-moderate-alcohol-consumption-on-urinary-testosterone-epitestosterone-ratio
#10
Sami Albeiroti, Brian Ahrens, Timofei Sobolevskii, Anthony W Butch
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28319499/developmental-venous-anomalies-mimicking-neoplasm-on-11c-methionine-pet-and-dsc-perfusion-mri
#11
Julie H Harreld, Mikhail Doubrovin, Elizabeth R Butch, Angela Edwards, Barry Shulkin
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28117638/analysis-of-lomustine-drug-content-in-fda-approved-and-compounded-lomustine-capsules
#12
Butch KuKanich, Matt Warner, Kevin Hahn
OBJECTIVE To determine the lomustine content (potency) in compounded and FDA-approved lomustine capsules. DESIGN Evaluation study. SAMPLE 2 formulations of lomustine capsules (low dose [7 to 11 mg] and high dose [40 to 48 mg]; 5 capsules/dose/source) from 3 compounders and from 1 manufacturer of FDA-approved capsules. PROCEDURES Lomustine content was measured by use of a validated high-pressure liquid chromatography method. An a priori acceptable range of 90% to 110% of the stated lomustine content was selected on the basis of US Pharmacopeia guidelines...
February 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28029285/effect-of-fentanyl-and-lidocaine-on-the-end-tidal-sevoflurane-concentration-preventing-motor-movement-in-dogs
#13
RANDOMIZED CONTROLLED TRIAL
Martin A Suarez, Reza Seddighi, Christine M Egger, Barton W Rohrbach, Sherry K Cox, Butch K KuKanich, Thomas J Doherty
OBJECTIVE To determine effects of fentanyl, lidocaine, and a fentanyl-lidocaine combination on the minimum alveolar concentration of sevoflurane preventing motor movement (MACNM) in dogs. ANIMALS 6 adult Beagles. PROCEDURES Dogs were anesthetized with sevoflurane in oxygen 3 times (1-week intervals). Baseline MACNM (MACNM-B) was determined starting 45 minutes after induction of anesthesia. Dogs then received 1 of 3 treatments IV: fentanyl (loading dose, 15 μg/kg; constant rate infusion [CRI], 6 μg/kg/h), lidocaine (loading dose, 2 mg/kg; CRI, 6 mg/kg/h), and the fentanyl-lidocaine combination at the same doses...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27996012/emergent-order-in-the-kagome-ising-magnet-dy3mg2sb3o14
#14
Joseph A M Paddison, Harapan S Ong, James O Hamp, Paromita Mukherjee, Xiaojian Bai, Matthew G Tucker, Nicholas P Butch, Claudio Castelnovo, Martin Mourigal, S E Dutton
The Ising model-in which degrees of freedom (spins) are binary valued (up/down)-is a cornerstone of statistical physics that shows rich behaviour when spins occupy a highly frustrated lattice such as kagome. Here we show that the layered Ising magnet Dy3Mg2Sb3O14 hosts an emergent order predicted theoretically for individual kagome layers of in-plane Ising spins. Neutron-scattering and bulk thermomagnetic measurements reveal a phase transition at ∼0.3 K from a disordered spin-ice-like regime to an emergent charge ordered state, in which emergent magnetic charge degrees of freedom exhibit three-dimensional order while spins remain partially disordered...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27993956/association-of-kidney-function-and-early-kidney-injury-with-incident-hypertension-in-hiv-infected-women
#15
MULTICENTER STUDY
Simon B Ascher, Rebecca Scherzer, Carmen A Peralta, Phyllis C Tien, Carl Grunfeld, Michelle M Estrella, Alison Abraham, Deborah R Gustafson, Marek Nowicki, Anjali Sharma, Mardge H Cohen, Anthony W Butch, Mary A Young, Michael R Bennett, Michael G Shlipak
Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injury: α-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, N-acetyl-β-d-glucosaminidase, and α1-acid-glycoprotein...
February 2017: Hypertension
https://www.readbyqxmd.com/read/27864935/adenoid-cystic-carcinoma-of-the-trachea-resulting-in-fatal-asphyxia
#16
Butch Huston, Victor Froloff, Kelly Mills, Michael McGee
Primary malignant tumors of the trachea are uncommon. The authors report a case of a 72-year-old female who died from asphyxia due to an undiagnosed obstructing adenoid cystic carcinoma of the trachea. The decedent became unresponsive while eating cereal and was pronounced upon arrival at the local hospital. The autopsy revealed a near occlusive tumor mass just superior to the bifurcation of the distal trachea. There was no evidence of aspiration. The death was the result of asphyxia due to obstruction of the trachea by an adenoid cystic carcinoma...
January 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27729501/working-conditions-occupational-injuries-and-health-among-filipino-fish-processing-workers-in-dutch-harbor-alaska
#17
Gabriel Macasiray Garcia, Butch de Castro
This study explored how unique environmental conditions in Alaska influenced occupational health and safety for Filipino fish processing workers, many of whom migrated from warm locations (e.g., the Philippines, California, and Nevada). In-depth interviews were conducted with 26 Filipino workers in one commercial fish processing company in Dutch Harbor. Results indicated that cold weather interferes with workers' job performance, increasing their risk for injury and illness, whereas the community's isolation and rural nature causes loneliness and boredom, resulting in more high-risk behaviors...
May 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/27691947/pharmacokinetic-evaluation-of-meloxicam-after-intravenous-and-intramuscular-administration-in-nile-tilapia-oreochromis-niloticus
#18
Daniel V Fredholm, Natalie D Mylniczenko, Butch KuKanich
Critically evaluating the pharmacokinetic behavior of a drug in the body provides crucial information about how to effectively treat a patient. Pharmacokinetic studies that exist in fish have primarily focused on drugs used to treat infectious disease, with minimal attention given to analgesic drugs. The objective of this study was to determine the pharmacokinetics of meloxicam (1 mg/kg) in Nile tilapia ( Oreochromis niloticus ) (n = 12). A single dose of meloxicam was administered either i.v. or i.m. Blood samples were obtained at predetermined times after drug injection...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27650796/spin-orbit-coupled-molecular-quantum-magnetism-realized-in-inorganic-solid
#19
Sang-Youn Park, S-H Do, K-Y Choi, J-H Kang, Dongjin Jang, B Schmidt, Manuel Brando, B-H Kim, D-H Kim, N P Butch, Seongsu Lee, J-H Park, Sungdae Ji
Molecular quantum magnetism involving an isolated spin state is of particular interest due to the characteristic quantum phenomena underlying spin qubits or molecular spintronics for quantum information devices, as demonstrated in magnetic metal-organic molecular systems, the so-called molecular magnets. Here we report the molecular quantum magnetism realized in an inorganic solid Ba3Yb2Zn5O11 with spin-orbit coupled pseudospin-½ Yb(3+) ions. The magnetization represents the magnetic quantum values of an isolated Yb4 tetrahedron with a total (pseudo)spin 0, 1 and 2...
September 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27617163/macrophage-inflammatory-protein-3-alpha-mip-3%C3%AE-ccl20-in-hiv-1-infected-individuals
#20
Najib Aziz, Roger Detels, L Cindy Chang, Anthony W Butch
OBJECTIVE: Uncontrolled HIV infection progresses to the depletion of systemic and mucosal CD4 and AIDS. Early HIV infection may be associated with increases in the concentration of MIP-3α in the blood and gut fluids. MIP-3α/CCL20 is the only chemokine known to interact with CCR6 receptors which are expressed on immature dendritic cells and both effector and memory CD8(+) and CD4(+) T cells. The role and prognostic value of blood levels of MIP-3α in HIV-infected individuals has yet to be described...
July 2016: Journal of AIDS & Clinical Research
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