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https://www.readbyqxmd.com/read/28363047/pharmacokinetics-of-a-single-dose-of-oral-and-subcutaneous-enrofloxacin-in-caribbean-flamingos-phoenicopterus-ruber-ruber
#1
Melissa R Nau, James W Carpenter, Butch KuKanich, Matt Warner
Enrofloxacin is a fluoroquinolone antimicrobial that is widely used in veterinary medicine because of its bactericidal activity and safety in a broad range of species. Caribbean flamingos, a member of the order Phoenicopteriformes, are popular in zoological collections and suffer from a variety of conditions that can result from or lead to bacterial infection. In this study, two groups of 7 adult captive Caribbean flamingos received a single dose of 15 mg/kg enrofloxacin, administered either orally or subcutaneously...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28339888/influence-of-low-and-moderate-alcohol-consumption-on-urinary-testosterone-epitestosterone-ratio
#2
Sami Albeiroti, Brian Ahrens, Timofei Sobolevskii, Anthony W Butch
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28319499/developmental-venous-anomalies-mimicking-neoplasm-on-11c-methionine-pet-and-dsc-perfusion-mri
#3
Julie H Harreld, Mikhail Doubrovin, Elizabeth R Butch, Angela Edwards, Barry Shulkin
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28117638/analysis-of-lomustine-drug-content-in-fda-approved-and-compounded-lomustine-capsules
#4
Butch KuKanich, Matt Warner, Kevin Hahn
OBJECTIVE To determine the lomustine content (potency) in compounded and FDA-approved lomustine capsules. DESIGN Evaluation study. SAMPLE 2 formulations of lomustine capsules (low dose [7 to 11 mg] and high dose [40 to 48 mg]; 5 capsules/dose/source) from 3 compounders and from 1 manufacturer of FDA-approved capsules. PROCEDURES Lomustine content was measured by use of a validated high-pressure liquid chromatography method. An a priori acceptable range of 90% to 110% of the stated lomustine content was selected on the basis of US Pharmacopeia guidelines...
February 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28029285/effect-of-fentanyl-and-lidocaine-on-the-end-tidal-sevoflurane-concentration-preventing-motor-movement-in-dogs
#5
RANDOMIZED CONTROLLED TRIAL
Martin A Suarez, Reza Seddighi, Christine M Egger, Barton W Rohrbach, Sherry K Cox, Butch K KuKanich, Thomas J Doherty
OBJECTIVE To determine effects of fentanyl, lidocaine, and a fentanyl-lidocaine combination on the minimum alveolar concentration of sevoflurane preventing motor movement (MACNM) in dogs. ANIMALS 6 adult Beagles. PROCEDURES Dogs were anesthetized with sevoflurane in oxygen 3 times (1-week intervals). Baseline MACNM (MACNM-B) was determined starting 45 minutes after induction of anesthesia. Dogs then received 1 of 3 treatments IV: fentanyl (loading dose, 15 μg/kg; constant rate infusion [CRI], 6 μg/kg/h), lidocaine (loading dose, 2 mg/kg; CRI, 6 mg/kg/h), and the fentanyl-lidocaine combination at the same doses...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27996012/emergent-order-in-the-kagome-ising-magnet-dy3mg2sb3o14
#6
Joseph A M Paddison, Harapan S Ong, James O Hamp, Paromita Mukherjee, Xiaojian Bai, Matthew G Tucker, Nicholas P Butch, Claudio Castelnovo, Martin Mourigal, S E Dutton
The Ising model-in which degrees of freedom (spins) are binary valued (up/down)-is a cornerstone of statistical physics that shows rich behaviour when spins occupy a highly frustrated lattice such as kagome. Here we show that the layered Ising magnet Dy3Mg2Sb3O14 hosts an emergent order predicted theoretically for individual kagome layers of in-plane Ising spins. Neutron-scattering and bulk thermomagnetic measurements reveal a phase transition at ∼0.3 K from a disordered spin-ice-like regime to an emergent charge ordered state, in which emergent magnetic charge degrees of freedom exhibit three-dimensional order while spins remain partially disordered...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27993956/association-of-kidney-function-and-early-kidney-injury-with-incident-hypertension-in-hiv-infected-women
#7
Simon B Ascher, Rebecca Scherzer, Carmen A Peralta, Phyllis C Tien, Carl Grunfeld, Michelle M Estrella, Alison Abraham, Deborah R Gustafson, Marek Nowicki, Anjali Sharma, Mardge H Cohen, Anthony W Butch, Mary A Young, Michael R Bennett, Michael G Shlipak
Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injury: α-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, N-acetyl-β-d-glucosaminidase, and α1-acid-glycoprotein...
February 2017: Hypertension
https://www.readbyqxmd.com/read/27864935/adenoid-cystic-carcinoma-of-the-trachea-resulting-in-fatal-asphyxia
#8
Butch Huston, Victor Froloff, Kelly Mills, Michael McGee
Primary malignant tumors of the trachea are uncommon. The authors report a case of a 72-year-old female who died from asphyxia due to an undiagnosed obstructing adenoid cystic carcinoma of the trachea. The decedent became unresponsive while eating cereal and was pronounced upon arrival at the local hospital. The autopsy revealed a near occlusive tumor mass just superior to the bifurcation of the distal trachea. There was no evidence of aspiration. The death was the result of asphyxia due to obstruction of the trachea by an adenoid cystic carcinoma...
January 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27729501/working-conditions-occupational-injuries-and-health-among-filipino-fish-processing-workers-in-dutch-harbor-alaska
#9
Gabriel Macasiray Garcia, Butch de Castro
This study explored how unique environmental conditions in Alaska influenced occupational health and safety for Filipino fish processing workers, many of whom migrated from warm locations (e.g., the Philippines, California, and Nevada). In-depth interviews were conducted with 26 Filipino workers in one commercial fish processing company in Dutch Harbor. Results indicated that cold weather interferes with workers' job performance, increasing their risk for injury and illness, whereas the community's isolation and rural nature causes loneliness and boredom, resulting in more high-risk behaviors...
October 11, 2016: Workplace Health & Safety
https://www.readbyqxmd.com/read/27691947/pharmacokinetic-evaluation-of-meloxicam-after-intravenous-and-intramuscular-administration-in-nile-tilapia-oreochromis-niloticus
#10
Daniel V Fredholm, Natalie D Mylniczenko, Butch KuKanich
Critically evaluating the pharmacokinetic behavior of a drug in the body provides crucial information about how to effectively treat a patient. Pharmacokinetic studies that exist in fish have primarily focused on drugs used to treat infectious disease, with minimal attention given to analgesic drugs. The objective of this study was to determine the pharmacokinetics of meloxicam (1 mg/kg) in Nile tilapia ( Oreochromis niloticus ) (n = 12). A single dose of meloxicam was administered either i.v. or i.m. Blood samples were obtained at predetermined times after drug injection...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27650796/spin-orbit-coupled-molecular-quantum-magnetism-realized-in-inorganic-solid
#11
Sang-Youn Park, S-H Do, K-Y Choi, J-H Kang, Dongjin Jang, B Schmidt, Manuel Brando, B-H Kim, D-H Kim, N P Butch, Seongsu Lee, J-H Park, Sungdae Ji
Molecular quantum magnetism involving an isolated spin state is of particular interest due to the characteristic quantum phenomena underlying spin qubits or molecular spintronics for quantum information devices, as demonstrated in magnetic metal-organic molecular systems, the so-called molecular magnets. Here we report the molecular quantum magnetism realized in an inorganic solid Ba3Yb2Zn5O11 with spin-orbit coupled pseudospin-½ Yb(3+) ions. The magnetization represents the magnetic quantum values of an isolated Yb4 tetrahedron with a total (pseudo)spin 0, 1 and 2...
September 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27617163/macrophage-inflammatory-protein-3-alpha-mip-3%C3%AE-ccl20-in-hiv-1-infected-individuals
#12
Najib Aziz, Roger Detels, L Cindy Chang, Anthony W Butch
OBJECTIVE: Uncontrolled HIV infection progresses to the depletion of systemic and mucosal CD4 and AIDS. Early HIV infection may be associated with increases in the concentration of MIP-3α in the blood and gut fluids. MIP-3α/CCL20 is the only chemokine known to interact with CCR6 receptors which are expressed on immature dendritic cells and both effector and memory CD8(+) and CD4(+) T cells. The role and prognostic value of blood levels of MIP-3α in HIV-infected individuals has yet to be described...
July 2016: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/27594536/urinary-human-chorionic-gonadotropin-isoform-concentrations-in-doping-control-samples
#13
Anthony W Butch, Getachew A Woldemariam
Anti-doping laboratories routinely use immunoassays to measure urinary concentrations of human chorionic gonadotropin (hCG). To minimize immunoassay differences and false positive screen results from inactive isoforms (free β-subunit (hCGβ), β-subunit core fragment (hCGβcf)) laboratories now use intact hCG instead of total hCG immunoassays to measure hCG. To determine the distribution of hCG isoforms in urine, we determined the concentrations of intact hCG, hCGβ, and hCGβcf in male urine samples based on immunoassay total hCG concentrations using a sequential immunoextraction and a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method...
November 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27552491/exploring-post-treatment-reversion-of-antimicrobial-resistance-in-enteric-bacteria-of-food-animals-as-a-resistance-mitigation-strategy
#14
Victoriya V Volkova, Butch KuKanich, Jim E Riviere
Antimicrobial drug use in food animals is associated with an elevation in relative abundance of bacteria resistant to the drug among the animal enteric bacteria. Some of these bacteria are potential foodborne pathogens. Evidence suggests that at least in the enteric nontype-specific Escherichia coli, after treatment the resistance abundance reverts to the background pre-treatment levels, without further interventions. We hypothesize that it is possible to define the distribution of the time period after treatment within which resistance to the administered drug, and possibly other drugs in case of coselection, in fecal bacteria of the treated animals returns to the background pre-treatment levels...
August 23, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27504239/contextual-determinants-on-the-meaning-of-the-n-word
#15
Keith Allan
Use of the word nigger is very often castigated as slurring the referent, but this ignores the context of use. For many people the word itself is a slur no matter what the context, and such people argue for its eradication from the English language. Eradicationists confuse the form of the word with its frequent use as a slur that discredits, slights, smears, stains, besmirches people of black African descent. In this paper I discuss several occurrences of the N word in Quentin Tarantino's film 'Pulp Fiction'...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27474776/evaluation-of-2-batched-pretreatment-systems-for-the-measurement-of-whole-blood-tacrolimus-on-the-architect-immunoassay-analyzer
#16
Sami Albeiroti, Michael O Alberti, Vincent Buggs, Gordon Swartz, Anthony W Butch, Julia C Drees, Kathleen A Kelly
BACKGROUND: Measurement of tacrolimus using the ARCHITECT immunoassay analyzer requires a manual extraction step that puts clinical laboratory workers at risk for ergonomic injury. Therefore, we developed 2 batched extraction systems for tacrolimus measurement on the ARCHITECT analyzer and describe their features herein. METHODS: Two batched extraction methods were developed at 2 different laboratories. The batched extraction methods allow processing of at least 20 specimens at a time...
November 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27443234/the-abiotic-chemistry-of-thiolated-acetate-derivatives-and-the-origin-of-life
#17
Kuhan Chandru, Alexis Gilbert, Christopher Butch, Masashi Aono, H James Cleaves
Thioesters and thioacetic acid (TAA) have been invoked as key reagents for the origin of life as activated forms of acetate analogous to acetyl-CoA. These species could have served as high-energy group-transfer reagents and allowed carbon insertions to form higher molecular weight compounds such as pyruvate. The apparent antiquity of the Wood-Ljungdahl CO2 fixation pathway and its presence in organisms which inhabit hydrothermal (HT) environments has also led to suggestions that there may be a connection between the abiotic chemistry of compounds similar to TAA and the origins of metabolism...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27208752/stability-of-cytokines-chemokines-and-soluble-activation-markers-in-unprocessed-blood-stored-under-different-conditions
#18
Najib Aziz, Roger Detels, Joshua J Quint, Qian Li, David Gjertson, Anthony W Butch
BACKGROUND: Biomarkers such as cytokines, chemokines, and soluble activation markers can be unstable when processing of blood is delayed. The stability of various biomarkers in serum and plasma was investigated when unprocessed blood samples were stored for up to 24h at room and refrigerator temperature. METHODS: Blood was collected from 16 healthy volunteers. Unprocessed serum, EDTA and heparinized blood was stored at room (20-25°C) and refrigerator temperature (4-8°C) for 0...
August 2016: Cytokine
https://www.readbyqxmd.com/read/27142002/intersections-and-evolution-of-butch-trans-categories-in-puerto-rico-needs-and-barriers-of-an-invisible-population
#19
Alíxida G Ramos-Pibernus, Sheilla L Rodríguez-Madera, Mark Padilla, Nelson Varas-Díaz, Ricardo Vargas Molina
Public health research among transgender populations globally has primarily focused on HIV/AIDS. However, trans men remain outside of this conceptual framework, with distinct but overlapping social contexts and needs. In Puerto Rico (PR), the trans men population has remained largely hidden within the 'butch' lesbian community. The objective of this article is to document the identity construction of trans men and 'buchas' (local term to refer to butch lesbians) in PR and its relation to their bodily practices and overall health...
August 2016: Global Public Health
https://www.readbyqxmd.com/read/27127976/pressure-resistant-intermediate-valence-in-the-kondo-insulator-smb_-6
#20
Nicholas P Butch, Johnpierre Paglione, Paul Chow, Yuming Xiao, Chris A Marianetti, Corwin H Booth, Jason R Jeffries
Resonant x-ray emission spectroscopy was used to determine the pressure dependence of the f-electron occupancy in the Kondo insulator SmB_{6}. Applied pressure reduces the f occupancy, but surprisingly, the material maintains a significant divalent character up to a pressure of at least 35 GPa. Thus, the closure of the resistive activation energy gap and onset of magnetic order are not driven by stabilization of an integer valent state. Over the entire pressure range, the material maintains a remarkably stable intermediate valence that can in principle support a nontrivial band structure...
April 15, 2016: Physical Review Letters
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