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https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#1
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#2
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29031046/contributors-to-young-drivers-driving-styles-a-comparison-between-israel-and-queensland
#3
Vera Skvirsky, Orit Taubman Ben-Ari, Timothy J Greenbury, Carlo G Prato
Among the numerous factors that contribute to young novice drivers' driving styles, personality characteristics, sociodemographic variables, family atmosphere, and friends' norms are known to have an important impact. However, cross-cultural comparisons are relatively rare in the safety literature concerning young drivers. This study aimed at comparing young drivers from Israel and Queensland (Australia) and examining the contribution of personality, sociodemographic, family and friends' aspects to their driving styles (reckless and careless; hostile and angry; anxious; patient and careful)...
October 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29029358/topographical-variations-between-splenic-flexure-and-spleen-a-study-with-ct-image-based-reconstruction
#4
Matteo Lavazza, Stefano Rausei, Vincenzo Pappalardo, Davide Inversini, Monica Mangini, Anna Maria Ierardi, Angkoon Anuwong, Hoon Yub Kim, Gianpaolo Carrafiello, Gianlorenzo Dionigi
INTRODUCTION: An issue that is seldom seen in the literature relates the detailed relationship of the splenic flexure (SF) and the spleen-both carefully examined-with a prospective approach in patients undergoing computer tomography (CT) scan. MATERIALS AND METHODS: SF localization has been searched and examined in 120 consecutive CT scans. Several different variables (age, gender, BMI, indication of CT scan, etc.) have been considered. In cooperation with the Radiology Division, we brought to completion a dedicated topographic outline, with the purpose of providing a detailed classification for SF localization...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29029348/dysregulation-of-sleep-behavioral-states-in-narcolepsy
#5
Sarah F Schoch, Esther Werth, Rositsa Poryazova, Thomas E Scammell, Christian R Baumann, Lukas L Imbach
Study Objectives: Patients with narcolepsy suffer from poor maintenance of wakefulness and fragmented night sleep, but the underlying mechanism of sleep boundary dysregulation remains little understood. The goal of this study was to quantify abnormal sleep-wake regulation in narcolepsy patients. Methods: Using a model-based approach (state space analysis), we analyzed overnight EEG recordings in ten patients with narcolepsy type 1 and age- and gender-matched healthy control subjects...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/29029293/multiple-chronic-conditions-in-spousal-caregivers-of-older-adults-with-functional-disability-associations-with-caregiving-difficulties-and-gains
#6
Courtney A Polenick, Amanda N Leggett, Noah J Webster, Benjamin H Han, Steven H Zarit, John D Piette
Objectives: Multiple chronic conditions (MCCs) are common and have harmful consequences in later life. Along with managing their own health, many aging adults care for an impaired partner. Spousal caregiving may be more stressful when caregivers have MCCs, particularly those involving complex management. Yet, little is known about combinations of conditions that are most consequential for caregiving outcomes. Method: Using a U.S. sample of 359 spousal caregivers and care recipients from the 2011 National Aging Trends Study and National Study of Caregiving, we examined three categories of MCCs based on similarity of management strategies (concordant only, discordant only, and both concordant and discordant) and their associations with caregiving difficulties and gains...
September 18, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29029006/large-scale-assessment-of-aortic-stenosis-facing-the-next-cardiac-epidemic
#7
Javier Ramos, Juan Manuel Monteagudo, Teresa González-Alujas, María Eugenia Fuentes, Marta Sitges, María Luisa Peña, Fernando Carrasco-Chinchilla, Tomás Echeverría, Alberto Bouzas, José Francisco Forteza Alberti, Dolores Mesa, Jesús María De La Hera, José Luis Zamorano
Aims: Aortic stenosis (AS) is the most frequent valvular disease in developed countries. As society grows older, the prevalence of AS increases. However, the real burden, current aetiology, severity distribution, and echocardiographic patterns of AS are not fully clear. The aim of the present study is to provide an accurate overall picture of AS, focusing on its epidemiology, aetiology, and echocardiographic features. Methods and results: A total of 29 502 consecutive echocardiograpies were prospectively included in this multicentre study...
September 28, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028914/trajectory-of-total-cholesterol-in-the-last-years-of-life-over-age-80-years-cohort-study-of-99-758-participants
#8
Judith Charlton, Rathi Ravindrarajah, Shota Hamada, Stephen H Jackson, Martin C Gulliford
Background: Epidemiological studies suggest that lower total cholesterol (TC) may be associated with higher mortality. This study aimed to evaluate whether a decline in total cholesterol before death might account for the association of TC with mortality over age 80 years. Methods: Cohort study using primary care electronic health records of 99,758 participants aged 80 to 105 years from the UK Clinical Practice Research Datalink (CPRD). Hazard ratios (HR) for all-cause mortality were adjusted for age, gender, frailty, comorbidity, blood pressure and smoking...
September 27, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028829/sodium-excretion-is-higher-in-patients-with-rheumatoid-arthritis-than-in-matched-controls
#9
Sarah Marouen, Guilhem du Cailar, Rachel Audo, Cedric Lukas, Gaelle Vial, Anne Tournadre, Emmanuel Barrat, Jean Ribstein, Bernard Combe, Jacques Morel, Claire I Daien
OBJECTIVE: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls. METHODS: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion. RESULTS: Sodium excretion was greater for patients with early RA (2,849±1,350 vs...
2017: PloS One
https://www.readbyqxmd.com/read/29028680/association-between-dioxin-and-metabolic-syndrome-by-age-and-sex-in-an-endemic-area-of-exposure-in-taiwan
#10
Chien-Yuan Huang, Ching-Chang Lee, Jung-Wei Chang, Ya-Yun Cheng, Yau-Chang Kuo, How-Ran Guo, Chen-Long Wu
BACKGROUND: Some of the effects of dioxins seem to be different between men and women, and exposures starting at an early age seem to have more prominent effects. Therefore, we conducted a study in Taiwan to evaluate the associations between exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and metabolic syndrome (MetS) starting at different ages in both sexes. METHODS: We recruited participants from an area where residents were exposed to PCDD/Fs released from a factory and defined serum PCDD/Fs levels ≥20 pg WHO98-TEQDF/g lipid as high dioxin levels...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028627/local-dynamic-stability-during-treadmill-walking-can-detect-children-with-developmental-coordination-disorder
#11
Merete B Speedtsberg, Sofie B Christensen, Jan Stenum, Thomas Kallemose, Jesper Bencke, Derek J Curtis, Bente R Jensen
OBJECTIVE: Developmental coordination disorder (DCD) is an innate impairment of motor coordination that affects basic locomotion and balance. This study investigated local dynamic stability of trunk accelerations during treadmill walking as an objective evaluation of gait stability and the sensitivity and specificity of this measure to discriminate children with DCD from typically developing children. METHOD: Eight children with DCD and ten age- and gender-matched typically developing children (TD) walked four minutes on a treadmill...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29028559/-what-s-the-right-thing-to-do-correctional-healthcare-providers-knowledge-attitudes-and-experiences-caring-for-transgender-inmates
#12
Kirsty A Clark, Jaclyn M White Hughto, John E Pachankis
RATIONAL: Incarcerated transgender individuals may need to access physical and mental health services to meet their general and gender-affirming (e.g., hormones, surgery) medical needs while incarcerated. OBJECTIVE: This study sought to examine correctional healthcare providers' knowledge of, attitudes toward, and experiences providing care to transgender inmates. METHOD: In 2016, 20 correctional healthcare providers (e.g., physicians, social workers, psychologists, mental health counselors) from New England participated in in-depth, semi-structured interviews examining their experiences caring for transgender inmates...
October 5, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29028553/a-nationwide-analysis-of-intensive-care-unit-admissions-2009-2014-the-korean-icu-national-data-kind-study
#13
Jinkyeong Park, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Yang Hyun Cho, Joongbum Cho, Chi-Min Park, Hyejeong Park, Juhee Cho, Eliseo Guallar, Gee Young Suh
PURPOSE: To evaluate unbiased information on the characteristics, procedures, and outcomes of intensive care unit (ICU) admissions in a long-term nationwide study. MATERIALS AND METHODS: Cohort study of all ICU admissions in patients >18years of age in Korea between August 1, 2009 and September 30, 2014 (1,553,673 ICU admissions in 1,265,509 patients). RESULTS: From August 2009 to September 2014, the age-standardized ICU admission rate was 744...
September 13, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29028482/adiposity-phenotypes-are-associated-with-type-2-diabetes-lap-index-body-adiposity-index-and-neck-circumference
#14
Aline Marcadenti, Flavio D Fuchs, Leila B Moreira, Miguel Gus, Sandra C Fuchs
BACKGROUND AND AIMS: Adiposity phenotypes can be detected by anthropometric indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. This study aimed to evaluate independent associations of T2DM with lipid accumulation product (LAP index), neck circumference (NC) and body adiposity index (BAI) in patients with hypertension. METHODS: A cross-sectional study was carried out among 430 patients with hypertension...
September 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29028456/visual-attention-patterns-differ-in-gynephilic-and-androphilic-men-and-women-depending-on-age-and-gender-of-targets
#15
Milena Vásquez-Amézquita, Juan David Leongómez, Michael C Seto, Mauricio Bonilla, Alexa Rodríguez-Padilla, Alicia Salvador
Visual attention patterns measured with eye-tracking techniques provide indirect clues about sexual response. This study aimed to test the category specificity of sexual responses to stimuli varying in gender and age by evaluating both early and late attention of gynephilic and androphilic men and women. We simultaneously presented sexually preferred and nonpreferred stimuli and measured time to first fixation and total duration of fixation on four areas of interest: entire body, then face, chest, and pelvis...
October 13, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29028365/exploring-self-care-and-preferred-supports-for-adult-parents-in-recovery-from-substance-use-disorders-qualitative-findings-from-a-feasibility-study
#16
Phyllis A Raynor, Charlene Pope, Janet York, Gigi Smith, Martina Mueller
Very little is known about the self-care behaviors (SCB) that adult parents employ and the preferred supports they utilize to maintain their recovery from substance use disorders (SUD) while also parenting their children. This study used a qualitative descriptive approach to explore perceptions of self-care and parenting to inform future self-care interventions for parents in early recovery. Nineteen mothers and fathers of at least one child between the ages of 6-18 were interviewed by telephone about parental self-care practices while in recovery from SUD, recovery management, and preferred supports in the community...
October 13, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29028227/a-strong-tb-programme-embedded-in-a-developing-primary-healthcare-system-is-a-lose-lose-situation-insights-from-patient-and-community-perspectives-in-cambodia
#17
Neisha Sundaram, Richard James, Um Sreynimol, Pen Linda, Joanne Yoong, Saint Saly, Pichenda Koeut, Mao Tan Eang, Richard Coker, Mishal S Khan
As exemplified by the situation in Cambodia, disease specific (vertical) health programmes are often favoured when the health system is fragile. The potential of such an approach to impede strengthening of primary healthcare services has been studied from a health systems perspective in terms of access and quality of care. In this bottom-up, qualitative study we investigate patient and community member experiences of health services when a strong tuberculosis (TB) programme is embedded into a relatively underutilized primary healthcare system...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028160/angiotensin-converting-enzyme-insertion-deletion-gene-polymorphism-in-egyptian-children-with-cap-a-case-control-study
#18
Heba Abouzeid, Usama M Alkholy, Mohammed A Abdou, Saeed M Morsy, Hind M Abdelrahman, Ashraf M Sherif, Nermin Abdalmonem, Mohammed E Hamed, Mayy A N Allah, Salah Al Morshedy, Shaimaa S A Elashkar, Maha A Noah, Mohamed S Hegab, Nagwa E Akeel, Mustafa I A Hashem, Heba H Gawish, Lobna Abdel Fattah
BACKGROUND: Community-acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for CAP risk. OBJECTIVES: In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29027898/surgery-versus-antibiotics-for-uncomplicated-appendicitis-which-would-a-medical-student-want
#19
Alison R Althans, Pierre Tamer, Justin T Brady, Emily Steinhagen, Vanessa P Ho
BACKGROUND: Recent data suggest that treatment of acute, uncomplicated appendicitis (AUA) with antibiotics is as effective as surgery. A 2015 study indicated that more than 50% of patients would choose antibiotic therapy. Medical students represent a unique population of potential patients with greater medical knowledge than the general public and possibly less bias than practicing physicians. Therefore, we aimed to evaluate what the MEDICAL STUDENT'S treatment choice for AUA would be and what factors influence these decisions...
October 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#20
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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