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https://www.readbyqxmd.com/read/28227684/a-novel-wireless-wearable-fluorescence-image-guided-surgery-system
#1
Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Shixin Jiang, Jinzuo Ye, Kunshan He, Chongwei Chi, Jie Tian, Yamin Mao, Yu An
Segmentectomy using indocyanine green (ICG) has become a primary treatment option to achieve a complete resection and preserve lung function in early-stage lung cancer. However, owing to a lack of appropriate intraoperative imaging systems, it is a huge challenge for surgeons to identify the intersegmental plane during the operation, leading to poor prognosis. Thus, we developed a novel wireless wearable fluorescence image-guided surgery system (LIGHTEN) for fast and accurate identification of intersegmental planes in human patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226990/validity-of-the-small-swine-model-for-human-electrical-safety-risks
#2
Michael A Brave, Dhanunjaya R Lakkireddy, Mark W Kroll, Dorin Panescu, Michael A Brave, Dhanunjaya R Lakkireddy, Mark W Kroll, Dorin Panescu, Dhanunjaya R Lakkireddy, Mark W Kroll, Dorin Panescu, Michael A Brave
Small swine are the most common model now used for electrical safety studies. Because of the significant anatomical and electrophysiological differences and the effect of animal size on the ventricular fibrillation (VF) threshold, there are concerns that these differences may exaggerate the risks of electrical devices to humans. We chose, as an illustrative and relevant example, swine studies of the TASER(®) conducted electrical weapon (CEW) as it has numerous published VF studies. We reviewed the published electrical swine safety studies for CEWs and compared them to finite element modeling studies, electrical safety standards, and epidemiological experience from field usage...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225581/effect-of-sonication-duration-and-power-on-ablation-depth-during-mr-guided-focused-ultrasound-of-bone
#3
Matthew D Bucknor, Eugene Ozhinsky, Rutwik Shah, Roland Krug, Viola Rieke
PURPOSE: To evaluate the effect of differences in sonication duration and power on the size of postcontrast ablation zone following magnetic resonance-guided focused ultrasound (MRgFUS) of bone in a swine femoral bone model. MATERIALS AND METHODS: Experimental procedures received approval from the Institutional Committee on Animal Research. MRgFUS was used to create two thermal lesions in the left femur of six pigs. Each target was subjected to six sonications. 400J of energy was used for each sonication...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225040/vulnerability-of-the-british-swine-industry-to-classical-swine-fever
#4
Thibaud Porphyre, Carla Correia-Gomes, Margo E Chase-Topping, Kokouvi Gamado, Harriet K Auty, Ian Hutchinson, Aaron Reeves, George J Gunn, Mark E J Woolhouse
Classical swine fever (CSF) is a notifiable, highly contagious viral disease of swine which results in severe welfare and economic consequences in affected countries. To improve preparedness, it is critical to have some understanding of how CSF would spread should it be introduced. Based on the data recorded during the 2000 epidemic of CSF in Great Britain (GB), a spatially explicit, premises-based model was developed to explore the risk of CSF spread in GB. We found that large outbreaks of CSF would be rare and generated from a limited number of areas in GB...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223970/tet-c-gene-transfer-between-chlamydia-suis-strains-occurs-by-homologous-recombination-after-co-infection-implications-for-spread-of-tetracycline-resistance-among-chlamydiaceae
#5
Hanna Marti, Hoyon Kim, Sandeep J Joseph, Stacey Dojiri, Timothy D Read, Deborah Dean
Chlamydia suis is a swine pathogen that has also recently been found to cause zoonotic infections of the human eye, pharynx, and gastrointestinal tract. Many strains contain a tetracycline class C gene [tet(C)] cassette that confers tetracycline resistance. The cassette was likely originally acquired by horizontal gene transfer from a Gram-negative donor after the introduction of tetracycline into animal feed in the 1950s. Various research groups have described the capacity for different Chlamydia species to exchange DNA by homologous recombination...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28223682/environmental-surfaces-used-in-entry-day-corralling-likely-contribute-to-the-spread-of-influenza-a-virus-in-swine-at-agricultural-fairs
#6
Sarah E Lauterbach, Michele M Zentkovich, Sarah W Nelson, Jacqueline M Nolting, Andrew S Bowman
No abstract text is available yet for this article.
February 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28223054/epicardial-adipose-tissue-removal-potentiates-outward-remodeling-and-arrests-coronary-atherogenesis
#7
Mikaela L McKenney-Drake, Stacey D Rodenbeck, Rebecca S Bruning, Ayeeshik Kole, Kyle W Yancey, Mouhamad Alloosh, Harold S Sacks, Michael Sturek
BACKGROUND: Pericoronary epicardial adipose tissue (cEAT) serves as a metabolic and paracrine organ that contributes to inflammation and is associated with macrovascular coronary artery disease (CAD) development. Although there is a strong correlation in humans between cEAT volume and CAD severity, there remains a paucity of experimental data demonstrating a causal link of cEAT to CAD. The current study tested the hypothesis that surgical resection of cEAT attenuates inflammation and CAD progression...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28222748/identification-of-host-cellular-proteins-that-interact-with-the-m-protein-of-a-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus-vaccine-strain
#8
Qian Wang, Yanwei Li, Hong Dong, Li Wang, Jinmei Peng, Tongqing An, Xufu Yang, Zhijun Tian, Xuehui Cai
BACKGROUND: The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to pose one of the greatest threats to the swine industry. M protein is the most conserved and important structural protein of PRRSV. However, information about the host cellular proteins that interact with M protein remains limited. METHODS: Host cellular proteins that interact with the M protein of HP-PRRSV were immunoprecipitated from MARC-145 cells infected with PRRSV HuN4-F112 using the M monoclonal antibody (mAb)...
February 22, 2017: Virology Journal
https://www.readbyqxmd.com/read/28222013/serum-triglyceride-measurements-the-commutability-of-reference-materials-and-the-accuracy-of-results
#9
Qinghui Meng, Weiyan Zhou, Chuanbao Zhang, Jie Zeng, Haijian Zhao, Tianjiao Zhang, Donghuan Wang, Jiangtao Zhang, Ying Yan, Wenxiang Chen
Background We aimed to evaluate the commutability of external quality assessment (EQA) materials, aqueous solutions, and commercial reference materials (calibrators and controls), and the accuracy of routine systems for serum triglyceride measurements. Methods According to the clinical and laboratory standards institute (CLSI) EP14-A3 protocol, we analyzed 43 fresh patient specimens and 32 processed materials including lyophilized samples, human serum pools, liquid reagents, swine sera and aqueous solutions by 14 routine methods (evaluated methods) and an isotope dilution liquid chromatography tandem mass spectrometry method (ID-LC/MS/MS) (comparative method)...
February 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28221814/an-amperometric-glucose-sensor-integrated-into-an-insulin-delivery-cannula-in-vitro-and-in-vivo-evaluation
#10
W Kenneth Ward, Gabriel Heinrich, Matthew Breen, Sheila Benware, Nicole Vollum, Kristin Morris, Chad Knutsen, Joseph D Kowalski, Scott Campbell, Jerry Biehler, Mark S Vreeke, Scott M Vanderwerf, Jessica R Castle, Robert S Cargill
BACKGROUND: Labeling prohibits delivery of insulin at the site of subcutaneous continuous glucose monitoring (CGM). Integration of the sensing and insulin delivery functions into a single device would likely increase the usage of CGM in persons with type 1 diabetes. METHODS: To understand the nature of such interference, we measured glucose at the site of bolus insulin delivery in swine using a flexible electrode strip that was laminated to the outer wall of an insulin delivery cannula...
February 21, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28221299/treatment-of-burn-and-surgical-wounds-with-recombinant-human-tropoelastin-produces-new-elastin-fibers-in-scars
#11
Hua Xie, Lisa Lucchesi, Bo Zheng, Elena Ladich, Teresa Pineda, Rose Merten, Cynthia Gregory, Michael Rutten, Kenton Gregory
Tropoelastin (TE), the soluble precursor of insoluble elastin fibers, is produced in minimal amounts in adults. Burn injuries result in inflexible collagen-rich scars because of lack of elastin fiber formation. We studied the feasibility of using recombinant human tropoelastin to enable elastin fiber production in burn and surgical scars to improve skin flexibility. In a swine hypertrophic burn scar model, normal skin and 3 × 3-cm partial thickness thermal burns underwent dermatome resection at 1 week post burn and randomized to four subcutaneous injections of saline or TE (either 0...
February 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28220713/the-influence-of-targeted-temperature-management-on-the-pharmacokinetics-of-drugs-administered-during-and-after-cardiac-arrest-a-systematic-review
#12
Tessa Crombez, Said Hachimi-Idrissi
OBJECTIVE: Pharmacokinetic parameters of drugs are widely investigated under normothermic conditions and normal hemodynamic parameters. The European Resuscitation Council recommends the use of targeted temperature management (TTM) with a target temperature of 34 °C in cardiac arrest (CA) patients. The aim of this literature review is to investigate the influence of CA combined with TTM on the pharmacokinetics of drugs. Results of preclinical and clinical studies are compared with each other...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28219820/versatile-carboxyl-terminus-of-capsid-protein-of-porcine-circovirus-type-2-were-recognized-by-monoclonal-antibodies-with-pluripotency-of-binding
#13
Ling-Chu Hung, Ivan-Chen Cheng
We designed the peptide (C3) mimetic carboxyl-terminus (Cterminus) of capsid protein of porcine circovirus type 2b (PCV2b-1A/1B) inducing humoral immunity and generating hybridomas. The positive reactivity of the mAbs to PCV2 capsid protein was demonstrated by Western blot assay. Those mAbs also showed positive signals on PCV2b infected swine lymphocytes by indirect immunofluorescence staining. The mAb 1H3 bound to three minimal linear epitopes (P62, DPPLNP; P67, DPPLNPK; P73, LKDPPLKP), which was located at Cterminus of the capsid protein of PCV2b-1A/1B, PCV2b-1C, and PCV2a-2A respectively...
February 17, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28219415/genotyping-and-investigating-capsular-polysaccharide-synthesis-gene-loci-of-non-serotypeable-streptococcus-suis-isolated-from-diseased-pigs-in-canada
#14
Han Zheng, Xiaotong Qiu, David Roy, Mariela Segura, Pengchen Du, Jianguo Xu, Marcelo Gottschalk
Streptococcus suis (S. suis) is an important swine pathogen and an emerging zoonotic agent. Most clinical S. suis strains express capsular polysaccharides (CPS), which can be typed by antisera using the coagglutination test. In this study, 79 S. suis strains recovered from diseased pigs in Canada and which could not be typed using antisera were further characterized by capsular gene typing and sequencing. Four patterns of cps locus were observed: (1) fifteen strains were grouped into previously reported serotypes but presented several mutations in their cps loci, when compared to available data from reference strains; (2) seven strains presented a complete deletion of the cps locus, which would result in an inability to synthesize capsule; (3) forty-seven strains were classified in recently described novel cps loci (NCLs); and (4) ten strains carried novel NCLs not previously described...
February 20, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28218698/genetic-assessment-of-african-swine-fever-isolates-involved-in-outbreaks-in-the-democratic-republic-of-congo-between-2005-and-2012-reveals-co-circulation-of-p72-genotypes-i-ix-and-xiv-including-19-variants
#15
Leopold K Mulumba-Mfumu, Jenna E Achenbach, Matthew R Mauldin, Linda K Dixon, Curé Georges Tshilenge, Etienne Thiry, Noelia Moreno, Esther Blanco, Claude Saegerman, Charles E Lamien, Adama Diallo
African swine fever (ASF) is a devastating disease of domestic pigs. It is a socioeconomically important disease, initially described from Kenya, but subsequently reported in most Sub-Saharan countries. ASF spread to Europe, South America and the Caribbean through multiple introductions which were initially eradicated-except for Sardinia-followed by re‑introduction into Europe in 2007. In this study of ASF within the Democratic Republic of the Congo, 62 domestic pig samples, collected between 2005-2012, were examined for viral DNA and sequencing at multiple loci: C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein)...
February 18, 2017: Viruses
https://www.readbyqxmd.com/read/28218362/mechanical-recanalization-for-clot-occlusion-of-venous-access-ports-experimental-study-using-ports-with-clot-occlusion
#16
Myung Gyu Song, Tae-Seok Seo, Baek-Hui Kim, Jeong Ho Kim
PURPOSE: To test the hypothesis that mechanical injection of saline is safe and effective in restoring patency of totally implantable venous access ports (TIVAPs) with clot occlusion. We devised an experimental port model for the evaluation of mechanical TIVAP recanalization prior to its clinical application. MATERIALS AND METHODS: The clot TIVAP occlusion model was constructed by filling the catheter with swine blood and incubating it at 37.5°C. The model was incubated for different lengths of time ranging from 1 day to 7 days...
February 8, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28214866/levosimendan-pretreatment-inhibits-myocardial-apoptosis-in-swine-after-coronary-microembolization
#17
Lang Li, Jiangyou Wang, Han Chen, You Zhou, Qiang Su, Tao Liu
BACKGROUND/AIMS: In addition to its cardiotonic effect, levosimendan has been thought to have multiple cardiovascular benefits, including anti-inflammatory and anti-apoptotic. Phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been revealed to be up-regulated in circumstances of coronary microembolization (CME), and the PTEN signaling pathway mediates myocardial apoptosis in swine after CME. However, whether this functional protein could be modified by pretreatment of levosimendan in models of CME has not been disclosed yet...
January 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214035/transesophageal-echocardiography-in-swine-establishment-of-a-baseline
#18
Katharina Huenges, Saskia Pokorny, Rouven Berndt, Jochen Cremer, Georg Lutter
The porcine model is a commonly used animal model in cardiovascular research. Along with new innovative operative techniques, choice of the optimal imaging technique is crucial. Transesophageal echocardiography (TEE) is a reliable imaging tool is highly important in a large number of experimental evaluations. But so far, TEE data for swine are limited, and few standard values have been established for the porcine model. The experience and baseline results for TEE in 45 swine are presented in this study. A full TEE examination was conducted in 45 German landrace or German large white swine, with an average body weight of 49 ± 3 kg, before experimental off-pump mitral valved stent implantation...
February 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28209472/role-of-antioxidants-in-horse-serum-mediated-vasculitis-in-swine-potential-relevance-to-early-treatment-in-mitigation-of-coronary-arteritis-in-kawasaki-disease
#19
Saji Philip, Wen-Chuan Lee, Kotturathu Mammen Cherian, Mei-Hwan Wu, Hung-Chi Lue
BACKGROUND: Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the pathogenesis of vasculitis in Kawasaki disease. Antioxidants have a significant role in the reduction of cardiovascular diseases in both human and animal studies. We tried giving vitamins A, E, and C to treat immune complex vasculitis, in the hope of mitigating coronary vasculitis in Kawasaki disease...
December 18, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28208710/metabolism-of-zearalenone-and-its-major-modified-forms-in-pigs
#20
Sabina B Binder, Heidi E Schwartz-Zimmermann, Elisabeth Varga, Gerlinde Bichl, Herbert Michlmayr, Gerhard Adam, Franz Berthiller
The Fusarium mycotoxin zearalenone (ZEN) can be conjugated with polar molecules, like sugars or sulfates, by plants and fungi. To date, the fate of these modified forms of ZEN has not yet been elucidated in animals. In order to investigate whether ZEN conjugates contribute to the total ZEN exposure of an individual, ZEN (10 µg/kg b.w.) and equimolar amounts of two of its plant metabolites (ZEN-14-O-β-glucoside, ZEN-16-O-β-glucoside) and of one fungal metabolite (ZEN-14-sulfate) were orally administered to four pigs as a single bolus using a repeated measures design...
February 8, 2017: Toxins
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