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https://www.readbyqxmd.com/read/28454224/direct-targeting-of-mapk8ip1-by-mir-10a-5p-is-a-major-mechanism-for-gastric-cancer-metastasis
#1
Yaoyong Lu, Ganbao Wei, Liangbo Liu, Yichao Mo, Qingsheng Chen, Lufei Xu, Rongwei Liao, Dehao Zeng, Kunqiang Zhang
MicroRNA (miRNA) are endogenous non-coding RNAs that suppress gene expression at the transcriptional, post-transcriptional or translational level by targeting the 3'-UTRs of specific mRNAs. miR-10a has been frequently reported to be aberrantly overexpressed in human tumors. In gastric cancer (GC), miR-10a has an important role in the metastasis from primary GC to lymph nodes. However, the role and relevant pathways of miR-10a in GC metastasis remain largely unknown. The present study was performed using 41 GC and 20 normal gastric mucosa tissues...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453458/reduced-ephb6-protein-in-gastric-carcinoma-and-associated-lymph-nodes-suggests-ephb6-as-a-gastric-tumor-and-metastasis-inhibitor
#2
Jiaxiu Liu, Bin Xu, Guoying Xu, Xiaolei Zhang, Xueyi Yang, Jiandong Wang
BACKGROUND: Eph receptors comprise the largest group of the receptor tyrosine kinase (RTK) family, and Eph receptors interacting with their ligand ephrins play an important role in development and tumorigenesis. EphB6, a special Eph receptor that lacks tyrosine kinase activity, was reported to be expressed in some human cancers. The clinical significance of EphB6 in gastric carcinoma has not been well investigated. METHODS: In this study, we detected expression of EphB6 protein in four gastric cancer cell lines and a set of gastric carcinoma tissue specimens by using immunohistochemistry...
April 21, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28445280/clinical-outcome-after-endoscopic-submucosal-dissection-for-early-gastric-cancer-of-absolute-and-expanded-indication
#3
Ju Seok Kim, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
This study evaluated the clinical outcome of endoscopic submucosal dissection (ESD) in minute submucosa (SM) invasion or undifferentiated early gastric cancer (EGC) and analyzed factors related to local recurrence after ESD.We retrospectively reviewed the chart of EGC patients, who underwent ESD at our tertiary hospital between January 2009 and 2015. The patients' characteristics and clinical outcomes were compared among an absolute indication, minute SM invasion, and undifferentiated EGC group.Of 885 total patients, 729 composed the absolute indication group; 65, the differentiated, SM invasion group; and 51, the undifferentiated, confined mucosa group...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28443906/the-enhanced-anti-obesity-effect-and-reduced-gastric-mucosa-irritation-of-capsaicin-loaded-nanoemulsions
#4
Muwen Lu, Yong Cao, Chi-Tang Ho, Qingrong Huang
Capsaicin (CAP), the major active component of chili peppers, is known to have thermogenic and weight-loss potential. The aim of this study was to investigate the anti-obesity effects of capsaicin-loaded nanoemulsions (C-NE) on male Sprague Dawley (SD) rats treated with a high-fat diet (HFD). The food grade C-NE was prepared using capsaicin, medium chain triacylglycerols (MCT) (Neobee 1053), sucrose stearate S-370, Tween 80 and distilled water with an emulsion droplet size of 168 nm and a capsaicin loading of 80...
April 26, 2017: Food & Function
https://www.readbyqxmd.com/read/28443084/gene-expression-profiling-of-transcription-factors-of-helicobacter-pylori-under-different-environmental-conditions
#5
Miguel A De la Cruz, Miguel A Ares, Kristine von Bargen, Leonardo G Panunzi, Jessica Martínez-Cruz, Hilda A Valdez-Salazar, César Jiménez-Galicia, Javier Torres
Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and causes peptic ulcers and gastric carcinoma. H. pylori strain 26695 has a small genome (1.67 Mb), which codes for few known transcriptional regulators that control bacterial metabolism and virulence. We analyzed by qRT-PCR the expression of 16 transcriptional regulators in H. pylori 26695, including the three sigma factors under different environmental conditions. When bacteria were exposed to acidic pH, urea, nickel, or iron, the sigma factors were differentially expressed with a particularly strong induction of fliA...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28441455/gene-expression-study-and-pathway-analysis-of-histological-subtypes-of-intestinal-metaplasia-that-progress-to-gastric-cancer
#6
Osmel Companioni, José Miguel Sanz-Anquela, María Luisa Pardo, Eulàlia Puigdecanet, Lara Nonell, Nadia García, Verónica Parra Blanco, Consuelo López, Victoria Andreu, Miriam Cuatrecasas, Maddi Garmendia, Javier P Gisbert, Carlos A Gonzalez, Núria Sala
BACKGROUND: Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC. METHODOLOGY: We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not progressing to GC, and the transcriptome of IM subtypes that had progressed to GC to those that did not progress...
2017: PloS One
https://www.readbyqxmd.com/read/28440519/-prevention-diagnosis-and-treatment-of-perioperative-complications-of-bariatric-and-metabolic-surgery
#7
Haifu Wu, Ming Zhong, Di Zhou, Chenye Shi, Heng Jiao, Wei Wu, Xinxia Chang, Jing Cang, Hua Bian
Surgical operation in treating obesity and type 2 diabetes is popularizing rapidly in China. Correct prevention and recognition of perioperation-related operative complications is the premise of ensuring surgical safety. Familiar complications of the operation include deep venous thrombosis, pulmonary artery embolism, anastomotic bleeding, anastomotic fistula and marginal ulcer. The prevention of deep venous thrombosis is better than treatment. The concrete measures contain physical prophylaxis (graduated compression stocking and intermittent pneumatic compression leg sleeves) and drug prophylaxis (unfractionated heparin and low molecular heparin), and the treatment is mainly thrombolysis or operative thrombectomy...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28438394/gastric-foveolar-dysplasia-a-survey-of-reporting-habits-and-diagnostic-criteria
#8
Stefano Serra, Rola Ali, Adrian C Bateman, Kaushik Dasgupta, Vikram Deshpande, David K Driman, David Gibbons, Andrea Grin, Sara Hafezi-Bakhtiari, Kieran Sheahan, Amitabh Srivastava, Eva Szentgyorgyi, Rajkumar Vajpeyi, Shaun Walsh, Lai Mun Wang, Runjan Chetty
This study aimed to ascertain views, incidence of reporting and diagnostic criteria for gastric foveolar dysplasia. A questionnaire, a post-questionnaire discussion and microscopic assessment of selected cases was conducted by gastrointestinal pathologists to explore the above-stated aims. Fifty-four percent of respondents never or rarely diagnosed gastric foveolar-type dysplasia. The general consensus was that round nuclei, lack of nuclear stratification, presence of inflammation/damage and surface maturation favoured reactive change; while architectural abnormalities/complexity and nuclear enlargement mainly were used to separate low-grade from high-grade foveolar dysplasia...
April 21, 2017: Pathology
https://www.readbyqxmd.com/read/28434216/can-endoscopic-ulcerations-in-early-gastric-cancer-be-clearly-defined-before-endoscopic-resection-a-survey-among-endoscopists
#9
Sung Min Park, Byung-Wook Kim, Joon Sung Kim, Young Wook Kim, Gi Jun Kim, Seung Ji Ryu
Background/Aims: Early gastric cancer (EGC) with ulcerations can be treated via endoscopic resection (ER) when it is differentiated pathologically, limited to the mucosa, and <3 cm in diameter. The presence of ulceration is a key factor in deciding treatment strategies and is usually diagnosed during endoscopic examination. The aim of this study was to evaluate whether ulcerations in EGC can be clearly defined among endoscopists and which factors are related to the differences. Methods: A survey questionnaire, composed of demographic features and endoscopic images of seven patients with EGC, was presented to the endoscopists via e-mail...
April 24, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28434172/lactobacillus-paracasei-strain-06tca19-suppresses-inflammatory-chemokine-induced-by-helicobacter-pylori-in-human-gastric-epithelial-cells
#10
Shiro Takeda, Keiji Igoshi, Chuluunbat Tsend-Ayush, Tsendesuren Oyunsuren, Ryoichi Sakata, Yasuhiro Koga, Yuo Arima, Masahiko Takeshita
Helicobacter (H.) pylori infection is an important risk factor for gastric cancer that causes gastric inflammation. Inflammatory chemokines such as interleukin (IL)-8 and regulated on activation normal T cell expressed and secreted (RANTES) are elevated in the gastric mucosa by H. pylori. This study aimed to investigate the effects of Lactobacillus paracasei strain 06TCa19, a probiotic strain, on IL-8 and RANTES expression and production induced by H. pylori using human gastric epithelial cell lines. Strain 06TCa19 was shown to suppress H...
April 22, 2017: Human Cell
https://www.readbyqxmd.com/read/28430953/gastric-proteins-muc5ac-and-tff1-as-potential-diagnostic-markers-of-colonic-sessile-serrated-adenomas-polyps
#11
Magomed Khaidakov, Keith K Lai, D Roudachevski, Julietta Sargsyan, Hannah E Goyne, Rish K Pai, Laura W Lamps, Curt H Hagedorn
Objectives: A subset of colon cancers originates from sessile serrated adenomas/polyps (SSA/Ps). Our goal was to identify markers for SSA/Ps that could aid in distinguishing them from hyperplastic polyps (HPs). Methods: We performed immunostaining for gastric proteins MUC5AC and TFF1 in formalin-fixed, paraffin-embedded (FFPE) samples of HPs (n = 47), SSA/Ps (n = 37), and normal colon (n = 30). Results: Control mucosa expressed only trace amounts of MUC5AC and TFF1...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28430952/a-strategy-for-helicobacter-immunohistochemistry-utilization-in-pediatric-practice-%C3%A2-insights-from-morphologic-and-cost-benefit-analyses
#12
Miriam R Conces, Christina A Arnold, Peter B Baker, Christopher M Carter, Bonita Fung, Vinay Prasad, Michael A Arnold
Objectives: Recent studies in adults have examined the utility of immunohistochemistry (IHC) in detecting Helicobacter in gastric biopsy specimens and reached differing conclusions. Dedicated cost-benefit analysis of Helicobacter IHC in pediatric gastric biopsy specimens has not been performed. Methods: From 1,955 pediatric gastric biopsies in a 1-year period, we identified 63 Helicobacter -positive and 120 Helicobacter -negative biopsy specimens. All cases were scored according to the Updated Sydney System for the severity of inflammation...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28429903/causes-of-interruptions-in-postoperative-enteral-nutrition-in-children-with-congenital-heart-disease
#13
Jirong Qi, Zhuo Li, Yueshuang Cun, Xiaonan Li
BACKGROUND AND OBJECTIVES: Perioperative nutritional support has become a hot topic in the clinical management of congenital heart disease (CHD). Postoperative enteral nutrition (EN) offers many benefits, such as protection of the intestinal mucosa, reduced risk of infection, and low clinical costs. Interruptions in EN frequently influence nutritional support and clinical outcomes. We, therefore, aimed to determine the causes of interruptions in postoperative EN in CHD patients and discuss clinical counter measures...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429649/fundic-gland-polyps-in-the-pediatric-population
#14
Amy Coffey, Kalyani Patel, Norma Quintanilla, Richard Kellermayer, Hao Wu
We retrospectively studied the clinical and histologic features of pediatric fundic gland polyps (FGPs) in 16 patients. FGPs had an endoscopic prevalence of 0.25% in 8527 pediatric gastric biopsies. Five patients had familial adenomatous polyposis (FAP). The median age of onset was 17.7 years in FAP and 17.3 years in sporadic patients. All syndromic patients were asymptomatic and FGPs were identified during surveillance for existing or concurrent colon polyps. They did not take antacids. In comparison, all 11 sporadic FGPs were identified during evaluation of symptomatic patients who had taken antacids (median duration 21 months)...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28425653/endoscopic-gastric-mucosal-atrophy-distinguishes-the-characteristics-of-superficial-esophagogastric-junction-adenocarcinoma
#15
Noriya Uedo, Toshiyuki Yoshio, Shigetaka Yoshinaga, Manabu Takeuchi, Waku Hatta, Tomonori Yano, Tokuma Tanuma, Osamu Goto, Akiko Takahashi, Daniel Tong, Yeong Yeh Lee, Yoshiko Nakayama, Shin Ichihara, Takuji Gotoda
BACKGROUND AND AIM: Western studies have suggested two distinct etiologies of esophagogastric junction (EGJ) cancer: Helicobacter pylori-associated atrophic gastritis and non-atrophic gastric mucosa resembling esophageal adenocarcinoma. The present study investigated whether endoscopic gastric mucosal atrophy can distinguish between these two types of EGJ adenocarcinoma. METHODS: Data were collected from patients with Siewert type II, T1 EGJ adenocarcinoma who underwent endoscopic or surgical resection at eight Japanese institutions in 2010-2015...
April 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28424913/can-further-gastrectomy-be-avoided-in-patients-with-incomplete-endoscopic-resection
#16
Hee Sung Kim, Ji Yong Ahn, Seon Ok Kim, Byung Sik Kim
BACKGROUND: Endoscopic resection (ER) is a widely accepted treatment for patients with early gastric cancer (EGC) with no lymph node metastasis. Occasionally, however, additional surgery is needed due to an incomplete resection. The purpose of this study was to detect clinical factors which might identify patients at greater risk of additional surgery after ER and to suggest an alternative treatment strategy for these patients. METHODS: This study retrospectively analyzed 350 patients with gastric cancer who underwent radical gastrectomy and lymphadenectomy after ER in a single institution between July 2004 and July 2014...
April 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28424674/global-fecal-and-plasma-metabolic-dynamics-related-to-helicobacter-pylori-eradication
#17
Theresa Wan-Chen Yap, Alex Hwong-Ruey Leow, Ahmad Najib Azmi, Damien L Callahan, Guillermo I Perez-Perez, Mun-Fai Loke, Khean-Lee Goh, Jamuna Vadivelu
Background:Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence H. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of H. pylori eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28423364/increased-expression-of-deleted-in-malignant-brain-tumors-dmbt1-gene-in-precancerous-gastric-lesions-findings-from-human-and-animal-studies
#18
Jone Garay, M Blanca Piazuelo, Lizbeth Lopez-Carrillo, Yelda A Leal, Sumana Majumdar, Li Li, Nataly Cruz-Rodriguez, Silvia J Serrano-Gomez, Carlos S Busso, Barbara G Schneider, Alberto G Delgado, Luis E Bravo, Angela M Crist, Stryder M Meadows, M Constanza Camargo, Keith T Wilson, Pelayo Correa, Jovanny Zabaleta
Helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. Initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene in tumor development is not completely understood...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422357/comparative-analysis-of-the-merino-sheep-and-iberian-red-deer-abomasum-during-prenatal-development
#19
Antonio Franco, Javier Masot, Eloy Redondo
The aim of this study is to describe differences in the ontogenesis of the abomasum in sheep (domestic ruminant) and deer (wild ruminant). Histomorphometric and immunohistochemical analysis were carried out on 50 embryos and fetuses of the sheep and 50 red deer from the first prenatal stages until birth. To compare similar periods of gestation in both species, we calculate the percentages of gestation. The appearance of the abomasum was earlier in the red deer (22% gestation) than in the sheep (25% gestation)...
April 19, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28421109/bleeding-meckel-s-diverticulum-in-children-the-diagnostic-value-of-double-balloon-enteroscopy
#20
Lan-Lan Geng, Pei-Yu Chen, Qiang Wu, Hui-Wen Li, Ding-You Li, Min Yang, Si-Tang Gong
Background. Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract. The purpose of this study was to evaluate the diagnostic value and safety of double-balloon enteroscopy (DBE) for bleeding MD in children. Methods. We included consecutive children who were highly suspected of MD between 2012 and 2013. All patients underwent Meckel's scan. DBE was performed for patient with negative Meckel's scan. An exploratory laparoscopy was performed in children with positive Meckel's scan or DBE...
2017: Gastroenterology Research and Practice
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