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https://www.readbyqxmd.com/read/29046055/topographic-distribution-pattern-of-morphologically-different-g-cells-in-the-murine-antral-mucosa
#1
Claudia Frick, Hanna Luisa Martin, Johanna Bruder, Kerstin Lang, Heinz Breer
Gastrin-secreting enteroendocrine cells (G cells) in the antrum play an important role in the regulation of gastric secretion, gastric motility and mucosal cell proliferation. Recently we have uncovered the existence of two subpopulations of G cells with pivotally different morphology and a distinct localization in the antral invaginations; the functional implications of the different G cell types are still elusive. In this study a transgenic mouse line in which EGFP is expressed under the control of a gastrin promoter was used to elucidate the distribution pattern of the two G cell types throughout the different regions of the antrum...
September 19, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29042979/mechanism-of-apoptosis-involved-in-gastric-mucosal-lesions-in-tibetans-with-high-altitude-polycythemia
#2
Kang Li, Luobu Gesang, Chaohui He
The Tibetan high plateau is a low-oxygen environment, which may cause the pathogenesis of high-altitude polycythemia (HAPC). Gastric mucosal lesions (GML) are a common complication of HAPC. The molecular mechanisms involved in HAPC-induced GML have remained to be fully elucidated and were therefore investigated in the present study. Gastric tissues of patients with heavy, HAPC-induced GML and healthy controls were assessed by ultrastructural and histopathological analysis. In addition, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis were used to detect cell apoptosis in the gastric mucosa tissues...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042978/antiplatelet-drug-ticagrelor-delays-gastric-ulcer-healing-in-rats
#3
Jing-Jing Li, Xin-Ying Wu, Jing-Lou Chen, Guan-Rong Chen, Jun Xu, Ye Gu, Hong-Ping Song
Adenosine diphosphate P2Y12 receptor antagonist clopidogrel is not sufficiently safe for the gastric mucosa in patients with high risk of peptic ulcer, since it may impair healing of gastric erosions. However, the safety of the novel P2Y12 receptor antagonist ticagrelor in the gastric mucosa has not been elucidated to date. The present study aimed to examine whether ticagrelor delays gastric ulcer healing and to elucidate the involved mechanisms. Gastric kissing ulcers were produced in rats by luminal application of acetic acid solution, and ticagrelor was administered at dose of 10 or 20 mg/kg/day orally for 7 days...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042646/effects-of-long-term-aspirin-use-on-molecular-alterations-in-precancerous-gastric-mucosa-in-patients-with-and-without-gastric-cancer
#4
Yuki Michigami, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Takeshi Morimoto, Kiron M Das, Hiroto Miwa
The risk of gastric cancer (GC) remains even after H. pylori eradication; thus, other combination treatments, such as chemopreventive drugs, are needed. We evaluated the effects of aspirin on genetic/epigenetic alterations in precancerous conditions, i.e., atrophic mucosa (AM) and intestinal metaplasia (IM), in patients with chronic gastritis who had taken aspirin for more than 3 years. A total of 221 biopsy specimens from 74 patients, including atrophic gastritis (AG) cases without aspirin use (control), AG cases with aspirin use (AG group), and GC cases with aspirin use (GC group), were analyzed...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038676/adult-onset-henoch-schonlein-purpura-duodenitis
#5
Emmanuel Ofori, Daryl Ramai, Mel A Ona, Charilaos Papafragkakis, Madhavi Reddy
Henoch-Schonlein purpura (HSP) is an immune-mediated vasculitis. HSP presents with purple spots on the skin (purpura), arthralgia, digestive problems, and kidney injury. HSP is most commonly seen in children, and rarely presents in adults. The pathogenesis involves the deposition of immune complexes in small to medium size blood vessels which leads to necrosis and inflammation. Most patients recover after symptomatic treatment, while more severe cases are treated with steroids. We report a 28-year-old female patient who presented with two episodes of hematemesis, worsening abdominal pain, and bloody diarrhea...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29033302/the-antimicrobial-susceptibility-of-helicobacter-pylori-in-strains-isolated-from-children-in-israel
#6
Nina Pastukh, Avi Peretz, Diana Brodsky, Natlya Isakovich, Maya Azrad, Avi On
BACKGROUND: Helicobacter pylori is a pathogen that causes inflammation in the gastric mucosa, and may lead to a peptic ulcer, perforation, or malignancy. Children are at risk of contracting H. pylori and developing subsequent morbidity. In children, diagnosis and management are difficult and merit a different approach than with adults. OBJECTIVE: To describe resistance rates of H. pylori to antibiotics such as amoxicillin, tetracycline, clarithromycin, metronidazole, levofloxacin, and Rifampicin...
October 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29029529/the-roles-of-maspin-expression-in-gastric-cancer-a-meta-and-bioinformatics-analysis
#7
Hua-Chuan Zheng, Bao-Cheng Gong
Maspin is a mammary serine protease inhibitor that is encoded by human SERPINB5 gene, and inhibits invasion and metastasis of cancer cells as a tumor suppressor. We performed a systematic meta- and bioinformatics analysis through multiple online databases up to Feb 10, 2017. We found down-regulated maspin expression in gastric cancer, compared with normal mucosa and dysplasia (p < 0.05). Maspin expression was negatively correlated with depth of invasion, TNM staging and dedifferentiation of gastric cancer (p < 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026594/subtypes-of-chronic-gastritis-in-patients-with-celiac-disease-before-and-after-gluten-free-diet
#8
Dolores Gabrieli, Fabiana Ciccone, Annalisa Capannolo, Angelo Viscido, Giorgio Valerii, Donatella Serva, Stefano Necozione, Gino Coletti, Giuseppe Calvisi, Dina Melideo, Giuseppe Frieri, Giovanni Latella
BACKGROUND: Celiac disease (CD) often manifests with dyspeptic symptoms and chronic gastritis is a common finding. AIM: To evaluate the frequency of lymphocytic gastritis (LG), chronic active gastritis (CAG), and chronic inactive gastritis (CIG) in patients with CD, before and after gluten-free diet (GFD). METHODS: A five-year prospective study including all consecutive patients with a new diagnosis of CD was conducted. Gastric and duodenal biopsy specimens taken both at the time of the CD diagnosis and at the first endoscopic control after 18-24 months on GFD were evaluated...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29025424/understanding-immune-phenotypes-in-human-gastric-disease-tissues-by-multiplexed-immunohistochemistry
#9
Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R G Williams, David W Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu
BACKGROUND: Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses. METHODS: We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1), cytotoxic T cells (CD8(+)T) and regulatory T cells (Foxp3), in formalin-fixed, paraffin-embedded tissues of various human gastric diseases...
October 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29021786/a-new-role-for-helicobacter-pylori-urease-contributions-to-angiogenesis
#10
Deiber Olivera-Severo, Augusto F Uberti, Miguel S Marques, Marta T Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R Carlini
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by this bacterium. In previous studies, we have shown that this protein is able to activate several cell types like neutrophils, monocytes, platelets, endothelial cells, and gastric epithelial cells. Angiogenesis is a physiological process implicated in growth, invasion and metastization of tumors. Here, we have analyzed the angiogenic potential of H...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29019560/pancreatoduodenectomy-brazilian-practice-patterns
#11
Orlando Jorge M Torres, Eduardo de Souza M Fernandes, Rodrigo Rodrigues Vasques, Fabio Luís Waechter, Paulo Cezar G Amaral, Marcelo Bruno de Rezende, Roland Montenegro Costa, André Luís Montagnini
BACKGROUND: Pancreatoduodenectomy is a technically challenging surgical procedure with an incidence of postoperative complications ranging from 30% to 61%. The procedure requires a high level of experience, and to minimize surgery-related complications and mortality, a high-quality standard surgery is imperative. AIM: To understand the Brazilian practice patterns for pancreatoduodenectomy. METHOD: A questionnaire was designed to obtain an overview of the surgical practice in pancreatic cancer, specific training, and experience in pancreatoduodenectomy...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29018360/adenosine-direct-and-indirect-actions-on-gastric-acid-secretion
#12
REVIEW
Rosa M Arin, Adriana Gorostidi, Hiart Navarro-Imaz, Yuri Rueda, Olatz Fresnedo, Begoña Ochoa
Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extracellular adenosine is a signaling molecule, able to modulate a vast range of physiologic responses in many cells and organs, including digestive organs. The adenosine A1, A2A, A2B, and A3 receptors are P1 purinergic receptors, G protein-coupled proteins implicated in tissue protection...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017601/mass-like-dieulafoy-s-lesion-associated-with-advanced-gastric-cancer-at-the-antrum-of-stomach-a-case-report-and-literature-review
#13
Hsi-Lan Huang, Chi Yan Leung, Chien-Jui Cheng
BACKGROUND: Dieulafoy's lesion, also known as a caliber-persistent artery, is a shallow, small, and rare lesion that occurs along the lesser curvature of proximal stomach. It is rare for a Dieulafoy's lesion to present as a mass-like lesion that coexists with gastric cancer. To our best knowledge, we report the first case and histopathological pictures of a mass-like Dieulafoy's lesion coexisting with advanced gastric cancer in the antrum of the stomach. CASE PRESENTATION: A 57-year-old female presented with a 6-month history of intermittent epigastric dull pain and dyspepsia...
October 10, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28994235/lipo-protein-emulsion-structure-in-the-diet-affects-protein-digestion-kinetics-intestinal-mucosa-parameters-and-microbiota-composition
#14
Marion Oberli, Véronique Douard, Martin Beaumont, Daphné Jaoui, Fabienne Devime, Sandy Laurent, Catherine Chaumontet, Damien Mat, Steven Le Feunteun, Camille Michon, Anne-Marie Davila, Gilles Fromentin, Daniel Tomé, Isabelle Souchon, Marion Leclerc, Claire Gaudichon, François Blachier
SCOPE: Food structure is a key factor controlling digestion and nutrient absorption. We tested the hypothesis that protein emulsion structure in the diet may affect digestive and absorptive processes. METHODS & RESULTS: Rats (n = 40) were fed for 3 weeks two diets chemically identical but based on lipid-protein liquid-fine (LFE) or gelled-coarse (GCE) emulsions that differ at the macro- and micro-structure levels. After an overnight fasting, they ingested a (15) N-labeled LFE or GCE test meal and were euthanized 0, 15min, 1h and 5h later...
October 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28993136/rebamipide-solution-a-novel-submucosal-injection-material-to-promote-healing-speed-and-healing-quality-of-ulcers-induced-by-endoscopic-submucosal-dissection
#15
Ai Fujimoto, Toshio Uraoka, Toshihiro Nishizawa, Masayuki Shimoda, Osamu Goto, Yasutoshi Ochiai, Tadateru Maehata, Teppei Akimoto, Yutaka Mitsunaga, Motoki Sasaki, Hiroyuki Yamamoto, Naohisa Yahagi
BACKGROUND AND AIMS: Rebamipide was administered perorally to protect the gastric mucosa. We assessed the efficacy and safety of a novel rebamipide solution as a submucosal injection material for endoscopic submucosal dissection (ESD) using an in vivo porcine model. METHODS: An endoscopist blinded to the test agents performed ESDs of hypothetical 30 mm lesions using a 2% rebamipide solution at 2 sites (rebamipide group) and a saline solution at the two other sites (control group) in the stomachs of 8 pigs...
October 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28990150/biomarkers-of-colorectal-cancer-risk-decrease-6%C3%A2-months-after-roux-en-y-gastric-bypass-surgery
#16
Sorena Afshar, Fiona Malcomson, Seamus B Kelly, Keith Seymour, Sean Woodcock, John C Mathers
PURPOSE: The impact of weight loss on obesity-related colorectal cancer (CRC) risk is not well defined. Previous studies have suggested that Roux-en-Y gastric bypass (RYGB) surgery may have an unexpected adverse impact on CRC risk. This study aimed to investigate the impact of RYGB on biomarkers of CRC risk. MATERIALS AND METHODS: Rectal mucosal biopsies and blood were obtained from patients undergoing RYGB (n = 22) and non-obese control participants (n = 20) at baseline and at a median of 6...
October 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28983255/the-regulatory-effects-of-lateral-hypothalamus-area-gabab-receptor-on-gastric-ischemia-reperfusion-injury-in-rats
#17
Lin Gao, Huiru Zhao, Tao Zhu, Yeliu Liu, Li Hu, Zhenguo Liu, Hai Huang, Fuxue Chen, Zhenxu Deng, Dechang Chu, Dongshu Du
HIGHLIGHTS The aim of the research was to determine the functional effects and molecular mechanisms of GABAB receptor on ischemia reperfusion-induced gastric injury in rats.The lateral hypothalamus area GABAB receptor attenuated the ischemia reperfusion-induced gastric injury by up-regulating the production of GABA, GABABR, and down-regulating P-GABABR in the brain.This work would provide a new therapeutic strategy for acute gastric injury. Gastric ischemia-reperfusion (GI-R) injury progression is largely associated with excessive activation of the greater splanchnic nerve (GSN)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28982106/pepsin-and-its-importance-for-functional-dyspepsia-relic-regulator-or-remedy
#18
Karl-Uwe Petersen
BACKGROUND: Functional dyspepsia is a heterogeneous disorder lacking an established therapeutic strategy. Historical treatment attempts with pepsin products were shrugged off, as a simple calculation shows that quantitative substitution is pointless. However, such attempts might have been right for the wrong reason. SUMMARY: Today, the role of pepsins is primarily seen in the provision of signalling amino acids (especially phenylalanine and tryptophan) and peptides, which initiate processes promoting digestion...
October 5, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28980874/analysis-of-co-expression-networks-for-circular-rnas-and-mrnas-reveals-that-circular-rnas-hsa_circ_0047905-hsa_circ_0138960-and-has-circrna7690-15-are-candidate-oncogenes-in-gastric-cancer
#19
Zhi Yong Lai, Yang Yang, Yichao Yan, Tao Li, Yan Sen Li, Zhu Wang, Zhanlong Shen, Ying-Jiang Ye, Ke-Wei Jiang, Shan Wang
Accumulating evidence has suggested that circular RNAs (circRNAs) play important roles in oncogenesis and tumor progression. However, our knowledge of circRNAs in gastric cancer (GC) remains limited. To investigate circRNAs involved in GC oncogenesis, we examined differentially-expressed circRNAs and mRNAs in GC tissues and paired noncancerous mucosa tissues using circRNA and mRNA microarrays. Next, we built gene co-expression networks according to the degree of correlation to predict the critical circRNAs in GC...
October 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28978001/tenascin-c-and-fibronectin-in-normal-esophageal-mucosa-barrett-s-esophagus-dysplasia-and-adenocarcinoma
#20
Joni Leppänen, Sara Bogdanoff, Petri P Lehenkari, Juha Saarnio, Joonas H Kauppila, Tuomo J Karttunen, Heikki Huhta, Olli Helminen
BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is poorly known. The aim of this study was to evaluate the expression of tenascin-C and fibronectin in esophageal adenocarcinoma and its precursor stages. RESULTS: Stromal tenascin-C and fibronectin expression were found in all evaluated lesion types. Expression of both molecules increased from gastric metaplasia towards adenocarcinoma (p<0...
September 15, 2017: Oncotarget
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