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https://www.readbyqxmd.com/read/28317588/applicability-of-endoscopic-submucosal-dissection-for-undifferentiated-early-gastric-cancer-mixed-histology-of-poorly-differentiated-adenocarcinoma-and-signet-ring-cell-carcinoma-is-a-worse-predictive-factor-of-nodal-metastasis
#1
In Seob Lee, Sol Lee, Young Soo Park, Chung Sik Gong, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) is not considered an appropriate treatment for undifferentiated early gastric cancer (UEGC) due to the higher risk of nodal metastases. We aimed to investigate predictive factors for nodal metastases in UEGCs, determine whether the tumor histology is an independent factor for it, and explore whether ESD is applicable for UEGC. METHODS: We reviewed the medical records of 1837 patients who underwent curative gastrectomy for poorly differentiated adenocarcinoma, signet ring cell carcinoma, and a mixed type of both tumors between 2008 and 2012...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28316127/melatonin-pretreatment-improves-gastric-mucosal-blood-flow-and-maintains-intestinal-barrier-function-during-hemorrhagic-shock-in-dogs
#2
Christian Vollmer, Andreas P M Weber, Martin Wallenfang, Till Hoffmann, Tabea Mettler-Altmann, Richard Truse, Inge Bauer, Olaf Picker, Alexander M Mathes
OBJECTIVE: Melatonin improves hepatic perfusion after hemorrhagic shock and may reduce stress-induced gastric lesions. This study was designed to investigate whether pretreatment with melatonin may influence gastric mucosal microcirculatory perfusion (μflow), oxygenation (μHbO2 ) or intestinal barrier function during physiological and hemorrhagic conditions in dogs. METHODS: In a randomized cross-over study, five anesthetized foxhounds received melatonin 100 μg/kg or vehicle (ethanol 5%) intravenously in the absence or presence of hemorrhagic shock (60 min, -20% blood volume)...
March 18, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28315903/reconsideration-of-the-primary-and-secondary-diagnostic-criteria-of-meckel-s-diverticulum-scintigraphy-a-study-of-93-confirmed-cases
#3
Ha Wu, Xiaofei Zhao, Yiwei Li, Ruifang Zhao
OBJECTIVE: Meckel's diverticulum scintigraphy (MDS) is a common method for diagnosing ectopic gastric mucosa (EGM), but atypical images are difficult to diagnose. This study aimed to improve the understanding of the existing diagnostic criteria through a review of confirmed cases. SUBJECTS AND METHODS: A total of 352 patients underwent MDS. Among 120 patients with a positive diagnosis, 106 underwent surgery. This study analyzed the imaging presentation, surgical records, and pathological results...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28306723/the-redefinition-of-helicobacter-pylori-lipopolysaccharide-o-antigen-and-core-oligosaccharide-domains
#4
Hong Li, Tiandi Yang, Tingting Liao, Aleksandra W Debowski, Hans-Olof Nilsson, Alma Fulurija, Stuart M Haslam, Barbara Mulloy, Anne Dell, Keith A Stubbs, Barry J Marshall, Mohammed Benghezal
Helicobacter pylori lipopolysaccharide promotes chronic gastric colonisation through O-antigen host mimicry and resistance to mucosal antimicrobial peptides mediated primarily by modifications of the lipid A. The structural organisation of the core and O-antigen domains of H. pylori lipopolysaccharide remains unclear, as the O-antigen attachment site has still to be identified experimentally. Here, structural investigations of lipopolysaccharides purified from two wild-type strains and the O-antigen ligase mutant revealed that the H...
March 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28303455/duodenal-cancer-in-a-young-patient-with-peuts-jeghers-syndrome-harboring-an-entire-deletion-of-the-stk11-gene
#5
Satoshi Teramae, Koichi Okamoto, Kumiko Tanaka, Reika Matsumoto, Shinji Kitamura, Tetsuo Kimura, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yoshimi Bando, Mitsuo Shimada, Tetsuji Takayama
A 21-year-old woman with Peuts-Jeghers syndrome (PJS) was referred to our hospital for gastrointestinal surveillance. She had been diagnosed as having PJS from a young age based on her family history and the presence of mucocutaneous pigmentation on her lips and oral mucosa. Her mother and brother had PJS harboring an entire deletion of the STK11 gene. She had tetralogy of Fallot, atrial tachycardia, sick sinus syndrome, and mental retardation in her past history. Esophagogastroduodenoscopy identified a protruded lesion with a depressed area that occupied the lumen half-circumferentially in the duodenal second portion and also showed a 10-mm protruded lesion on the anterior wall of the lower gastric body...
March 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28296749/gastrointestinal-involvement-by-mantle-cell-lymphoma-observed-by-endoscopy-a-case-report
#6
De-Ming Li, Yue-Ping Jiang
INTRODUCTION: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin B-cell lymphoma, accounting for 6% of all non-Hodgkin lymphoma. The typical appearance of intestinal MCL is multiple lymphomatous polyposis, whereas presentation as protruding lesions is uncommon. We herein report the case of a 64-year-old male patient who was admitted to our hospital with epigastric pains. On endoscopy, submucosal neoplasma were identified in the gastric antrum, the duodenal bulb, and the rectum. On endoscopic ultrasonography (EUS) (OLYMPUS EUS EU-ME2, Miniprobe sonography), the lesions were homogeneously hypoechoic and originated from the submucous layer or muscularis mucosa...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294994/is-ghrelin-synthesized-in-the-central-nervous-system
#7
REVIEW
Agustina Cabral, Eduardo J López Soto, Jacques Epelbaum, Mario Perelló
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced...
March 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28294226/insight-into-the-gastro-duodenal-digestion-resistance-of-soybean-proteins-and-potential-implications-for-residual-immunogenicity
#8
Elisabetta De Angelis, Rosa Pilolli, Simona L Bavaro, Linda Monaci
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative correlation between immunoreactivity and resistance to the human gastrointestinal (GI) digestion has drawn attention to investigating soybean proteins digestibility. In this work, we provided further insights into this field by performing in vitro simulated GI digestion experiments directly on ground soybean seeds, to provide more realistic results obtained from the digestion of the whole food matrix...
March 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28293390/effect-of-sodium-hydrosulfide-on-mrna-expression-of-prostaglandin-e2-receptors-in-response-to-mucosal-acidification-and-distention-induced-gastric-acid-secretion-in-rats
#9
Seyyed Ali Mard, Simin Mahini, Mahin Dianat, Yaghoob Farbood
OBJECTIVES: Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors in response to mucosal acidification and distention-induced gastric acid secretion in rats. MATERIALS AND METHODS: Fasted rats were randomly assigned into 4 groups (n=6/group)...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28293092/clinicopathological-and-prognostic-significance-of-aberrant-arpin-expression-in-gastric-cancer
#10
Tao Li, Hong-Mei Zheng, Nai-Mei Deng, Ying-Jian Jiang, Jiang Wang, Dian-Liang Zhang
AIM: To detect the expression of Arpin, and determine its correlation with clinicopathological characteristics and the prognosis of gastric cancer (GC) patients. METHODS: A total of 176 GC patients were enrolled as study subjects and classified into groups according to different clinicopathological variables. GC mucosal tissues were obtained via surgery. Another 43 paraffin-embedded tissue blocks of normal gastric epithelium (> 5 cm away from the edge of the tumor) were included in the control group...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28288705/clinical-aspects-and-therapy-of-gastrointestinal-malt-lymphoma
#11
REVIEW
Catherine Thieblemont, Emanuele Zucca
Extranodal marginal zone B-cell lymphomas of the mucosa associated lymphoid tissue (MALT) arise from lymphoid populations that are induced by chronic inflammation in extranodal sites. Among the MALT lymphomas, gastrointestinal (GIT) MALT lymphoma is the most frequent compared to non-GIT MALT lymphoma arising from other sites. Gastric MALT lymphoma has been the first to be described with the evidence of an etiopathogenetic link provided by the association between Helicobacter pylori-positive gastritis and gastric MALT lymphoma...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28288471/early-stage-gastric-cancer-can-be-found-in-improved-atrophic-mucosa-over-time-from-successful-helicobacter-pylori-eradication
#12
Atsushi Majima, Osamu Handa, Yuji Naito, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yoshito Itoh
BACKGROUND/AIMS: Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication. METHODS: This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28287480/helicobacter-pylori-outer-membrane-protein-related-pathogenesis
#13
REVIEW
Yuichi Matsuo, Yasutoshi Kido, Yoshio Yamaoka
Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known in H. pylori, and their associated host cell responses have been gradually clarified. Many studies have demonstrated that OMPs are essential to CagA translocation into gastric cells via the Type IV secretion system of H...
March 11, 2017: Toxins
https://www.readbyqxmd.com/read/28286288/doxycycline-induced-gastrointestinal-injury
#14
Kajsa Affolter, Wade Samowitz, Kathleen Boynton, Erinn Downs Kelly
Doxycycline induced gastric injury is a rarely recognized side effect of a common medication. Only two cases have previously described the distinctive capillary degeneration identified in gastric mucosa. We expanded on this by describing additional involved sites, endoscopic findings and patient characteristics. Design Gastrointestinal biopsy materials for cases indexed with the word "doxycycline" were retrieved and the histology reviewed. The medical record was used to obtain clinical details. Three cases with biopsy materials were identified from the search and doxycycline ingestion was confirmed...
March 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28285810/-gastric-adenoma-of-pyloric-type-associated-with-familial-adenomatous-polyposis-a-rare-histological-type-not-to-be-overlooked
#15
Jérôme Didier, Peggy Dartigues, Ranya Soufan, David Malka, Pascal Burtin, Jean-Yves Scoazec
We report here two cases of gastric adenomas of pyloric type diagnosed during the follow-up of familial adenomatous polyposis (FAP). This rare histological lesion has been only recently described in this particular context and its clinical and pathological spectrum remains to be evaluated. Our two cases were very different in their clinical and endoscopic presentation. In the first patient, the lesion was diagnosed late during the evolution of FAP; it was very large and protruded above the adjacent mucosa; because of its large size, its treatment proved to be difficult...
March 9, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28279347/helicobacter-pylori-adapts-to-chronic-infection-and-gastric-disease-via-ph-responsive-baba-mediated-adherence
#16
Jeanna A Bugaytsova, Oscar Björnham, Yevgen A Chernov, Pär Gideonsson, Sara Henriksson, Melissa Mendez, Rolf Sjöström, Jafar Mahdavi, Anna Shevtsova, Dag Ilver, Kristof Moonens, Macarena P Quintana-Hayashi, Roman Moskalenko, Christopher Aisenbrey, Göran Bylund, Alexej Schmidt, Anna Åberg, Kristoffer Brännström, Verena Königer, Susanne Vikström, Lena Rakhimova, Anders Hofer, Johan Ögren, Hui Liu, Matthew D Goldman, Jeannette M Whitmire, Jörgen Ådén, Justine Younson, Charles G Kelly, Robert H Gilman, Abhijit Chowdhury, Asish K Mukhopadhyay, G Balakrish Nair, Konstantinos S Papadakos, Beatriz Martinez-Gonzalez, Dionyssios N Sgouras, Lars Engstrand, Magnus Unemo, Dan Danielsson, Sebastian Suerbaum, Stefan Oscarson, Ludmilla A Morozova-Roche, Anders Olofsson, Gerhard Gröbner, Jan Holgersson, Anders Esberg, Nicklas Strömberg, Maréne Landström, Angela M Eldridge, Brett A Chromy, Lori M Hansen, Jay V Solnick, Sara K Lindén, Rainer Haas, Andre Dubois, D Scott Merrell, Staffan Schedin, Han Remaut, Anna Arnqvist, Douglas E Berg, Thomas Borén
The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time...
March 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28279343/a-sour-relationship-between-baba-and-lewis-b
#17
Masanori Hatakeyama
Helicobacter pylori survives in the hostile acidic environment of the stomach through extensive adaptation. In this issue of Cell Host & Microbe, Bugaytsova et al. (2017) report an acid-responsive, reversible adherence of H. pylori BabA to the gastric mucosa, the strength of which is tuned by dynamic BabA adaptation.
March 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28277954/physiological-responses-to-fasting-and-estivation-for-the-three-toed-amphiuma-amphiuma-tridactylum
#18
Matthew E Smith, Stephen M Secor
Species of Amphiuma enter a state of subterranean estivation with the drying of their aquatic habitat. Characteristic of amphibian fasting and estivation is an initial depression of metabolism and tissue mass and function with fasting, followed by a more pronounced adaptive decrease in metabolism and tissue function with estivation. We hypothesized that Amphiuma likewise experiences a two-stage set of responses to estivation. Therefore, we examined the physiological responses of the three-toed amphiuma (Amphiuma tridactylum) to fasting and estivation treatments...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28276835/autoimmune-gastritis-relationships-with-anemia-and-helicobacter-pylori-status
#19
Vincenzo Villanacci, Giovanni Casella, Francesco Lanzarotto, Camillo Di Bella, Angelo Sidoni, Moris Cadei, Tiziana Salviato, Maria Pina Dore, Gabrio Bassotti
BACKGROUND: Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria. AIMS: We report our clinical and pathological experience with AIG. METHODS: Data from patients with a diagnosis of AIG seen in the period January 2002-December 2012 were retrieved. Only patients with complete sets of biopsies were analyzed. RESULTS: Data from 138 patients were available for analysis...
February 17, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276823/the-role-of-malat-1-in-the-invasion-and-metastasis-of-gastric-cancer
#20
Di Chen, Lili Liu, Kai Wang, Haiyan Yu, Yafang Wang, Jiaming Liu, Yang Guo, Hongbo Zhang
OBJECTIVES: The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) has been reported to be over-expressed in several cancer types. However, its role in gastric cancer (GC) remains unclear. In the present study, we examined the expression of MALAT-1 in GC cells and tissues and explored its role in GC cell migration and invasion. MATERIALS AND METHODS: Real-time quantitative polymerase chain reaction (qRT-PCR) was used to analyze the expression level of MALAT-1 in six GC cell lines and 20 gastric tissues (20 GC and 20 adjacent normal mucosa)...
March 1, 2017: Scandinavian Journal of Gastroenterology
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