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https://www.readbyqxmd.com/read/27895274/disease-severity-prediction-by-spirometry-in-adults-with-visceral-leishmaniasis-from-minas-gerais-brazil
#1
Isabel A Maia, Frank S Bezerra, André Luis Pereira de Albuquerque, Heitor F Andrade, Valdir S Amato
Visceral leishmaniasis (VL) is associated with interstitial pneumonitis according to histology and radiology reports. However, studies to address the functional impact on respiratory function in patients are lacking. We assessed pulmonary function using noninvasive spirometry in a cross-sectional study of hospitalized adult VL patients from Minas Gerais, Brazil, without unrelated lung conditions or acute infections. Lung conditions were graded as normal, restrictive, obstructive, or mixed patterns, according to Brazilian consensus standards for spirometry...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27706554/upregulation-of-icam-1-and-il-1%C3%AE-protein-expression-promotes-lung-injury-in-chronic-obstructive-pulmonary-disease
#2
Y X Wang, M L Ji, C Y Jiang, Z B Qian
Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves multiple cytokines, aggregation, and activation of neutrophils in the airway and lung tissue, and release of proteases and oxygen free radicals. In this study, a rat model of COPD was established by daily cigarette smoke exposure plus endotoxin treatment (the experimental group)...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27701716/the-influence-of-type-1-diabetes-mellitus-on-pulmonary-function-and-exercise-capacity-results-from-the-study-of-health-in-pomerania-ship
#3
B Stubbe, S Schipf, C Schäper, S B Felix, A Steveling, M Nauck, H Völzke, H Wallaschofski, N Friedrich, R Ewert, T Ittermann, S Gläser
Background: Diabetes mellitus Type 1 (T1DM) is associated with metabolic and microvascular diseases as part of a multi-organ and multi-systemic disorder. The dense network of capillary vessels in the lungs may change during the course of the development of microangiopathy. The connective tissue as well as alveoli may be subjected to non-enzymatic glycosylation of proteins which may in turn affect pulmonary function. Previous studies investigating lung function in patients with type 1 diabetes have only been performed on small numbers of patients...
October 4, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27666650/asthma-transition-from-childhood-into-adulthood
#4
Oliver Fuchs, Thomas Bahmer, Klaus F Rabe, Erika von Mutius
Asthma is the most prevalent chronic respiratory disease both in children and adults and resembles a complex syndrome rather than a single disease. Different methods have been developed to better characterise distinct asthma phenotypes in childhood and adulthood. In studies of adults, most phenotyping relies on biomaterials from the lower airways; however, this information is missing in paediatric studies because of restricted accessibility. Few patients show symptoms throughout childhood, adolescence, and adulthood...
September 22, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27566377/office-based-dlco-tests-help-pulmonologists-to-make-important-clinical-decisions
#5
REVIEW
Paul Enright Md
Measurement of diffusing capacity of the lungs for carbon monoxide (DLCO), also known as transfer factor, is the second most important pulmonary function test (PFT), after spirometry. Previously available only in hospital-based PFT labs, DLCO testing is now available at outpatient clinics using a portable device. Compared to spirometry tests, assessments with these devices require very little effort. The patient breathes quietly, inhales the test gas, holds the breath for ten seconds, and then exhales. In adult smokers with post-bronchodilator airway obstruction, a low DLCO greatly increases the probability of the emphysema phenotype of COPD due to cigarette smoking, while a normal DLCO makes chronic asthma more likely...
September 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27512933/-chronic-obstructive-pulmonary-disease-copd-rational-diagnostics-and-therapy
#6
R Burkhardt, W Pankow
In general chronic obstructive pulmonary disease (COPD) can be diagnosed in family practice from history and spirometry. Inconclusive spirometry findings have to be assessed further by techniques available in a pulmonologist's office. Further testing is done for differential diagnostic reasons and for prognostic appraisal. Successful smoking cessation importantly alters the natural downhill course of the disease. Patient education and rehabilitative interventions (e. g. participation in lung sport groups) help to improve life quality...
August 2016: Pneumologie
https://www.readbyqxmd.com/read/27382160/ascorbate-attenuates-pulmonary-emphysema-by-inhibiting-tobacco-smoke-and-rtp801-triggered-lung-protein-modification-and-proteolysis
#7
Indranil Gupta, Souradipta Ganguly, Christine R Rozanas, Dennis J Stuehr, Koustubh Panda
Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, but also activate Rtp801, a key proinflammatory cellular factor involved in tobacco smoke-induced lung damage. Rtp801 triggers nuclear factor κB and consequent inducible NOS (iNOS)-mediated overproduction of NO, which in combination with excess superoxide produced during Rtp801 activation, contribute to increased oxido-nitrosative stress and lung protein nitration...
July 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27302510/mild-lung-restriction-in-breast-cancer-patients-after-hypofractionated-and-conventional-radiation-therapy-a-3-year-follow-up
#8
Sylvia Verbanck, Shane Hanon, Daniel Schuermans, Hilde Van Parijs, Vincent Vinh-Hung, Geertje Miedema, Dirk Verellen, Guy Storme, Christel Fontaine, Jan Lamote, Mark De Ridder, Walter Vincken
PURPOSE: To assess the effect of radiation therapy on lung function over the course of 3 years. METHODS AND MATERIALS: Evolution of restrictive and obstructive lung function parameters was investigated in 108 breast cancer participants in a randomized, controlled trial comparing conventional radiation therapy (CR) and hypofractionated tomotherapy (TT) (age at inclusion ranging 32-81 years). Spirometry, plethysmography, and hemoglobin-corrected diffusing capacity were assessed at baseline and after 3 months and 1, 2, and 3 years...
July 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27259805/a-retrospective-study-of-two-populations-to-test-a-simple-rule-for-spirometry
#9
Jill A Ohar, Barbara P Yawn, Gregg L Ruppel, James F Donohue
BACKGROUND: Chronic lung disease is common and often under-diagnosed. METHODS: To test a simple rule for conducting spirometry we reviewed spirograms from two populations, occupational medicine evaluations (OME) conducted by Saint Louis and Wake Forest Universities at 3 sites (n = 3260, mean age 64.14 years, 95 % CI 58.94-69.34, 97 % men) and conducted by Wake Forest University preop clinic (POC) at one site (n = 845, mean age 62.10 years, 95 % CI 50...
June 4, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27165420/persistent-empiric-copd-diagnosis-and-treatment-after-pulmonary-function-test-showed-no-obstruction
#10
Spyridon Fortis, Edward O Corazalla, David R Jacobs, Hyun J Kim
BACKGROUND: Health-care providers often diagnose and empirically treat COPD without a confirmative pulmonary function test (PFT) or even despite a PFT that is not diagnostic of obstructive lung disease. We hypothesized that a portion of patients continue to carry a persistent empiric COPD diagnosis and receive treatment with bronchodilators and inhaled steroids after a PFT shows no obstruction. METHODS: We retrospectively reviewed single PFT sessions with both spirometry and plethysmography in 1,805 subjects...
September 2016: Respiratory Care
https://www.readbyqxmd.com/read/27103389/prognostic-assessment-in-copd-without-lung-function-the-b-ae-d-indices
#11
Lucas Boeck, Joan B Soriano, Marjolein Brusse-Keizer, Francesco Blasi, Konstantinos Kostikas, Wim Boersma, Branislava Milenkovic, Renaud Louis, Alicia Lacoma, Remco Djamin, Joachim Aerts, Antoni Torres, Gernot Rohde, Tobias Welte, Pablo Martinez-Camblor, Janko Rakic, Andreas Scherr, Michael Koller, Job van der Palen, Jose M Marin, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristobal Esteban, Juan J Soler-Cataluña, Juan P de-Torres, Marc Miravitlles, Bartolome R Celli, Michael Tamm, Daiana Stolz
Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our aim was to provide and validate a simplified COPD risk index independent of lung function.The PROMISE study (n=530) was used to develop a novel prognostic index. Index performance was assessed regarding 2-year COPD-related mortality and all-cause mortality. External validity was tested in stable and exacerbated COPD patients in the ProCOLD, COCOMICS and COMIC cohorts (total n=2988)...
June 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27075769/the-effects-of-waterpipe-tobacco-smoking-on-health-outcomes-an-updated-systematic-review-and-meta-analysis
#12
Reem Waziry, Mohammed Jawad, Rami A Ballout, Mohammad Al Akel, Elie A Akl
BACKGROUND AND AIMS: A systematic review conducted in 2008 found significant associations between waterpipe tobacco smoking and lung cancer, respiratory disease, periodontal disease and low birthweight. Since then, a number of relevant studies have been published. The objective of this study was to update the systematic review on the effects of waterpipe tobacco smoking on health outcomes. METHODS: In May 2015 we electronically searched the following databases with no date restrictions: MEDLINE, EMBASE and the ISI Web of Science using a detailed search strategy with no language restrictions...
April 13, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27061878/long-term-prognosis-of-asthma-chronic-obstructive-pulmonary-disease-and-asthma-chronic-obstructive-pulmonary-disease-overlap-in-the-copenhagen-city-heart-study-a-prospective-population-based-analysis
#13
Peter Lange, Yunus Çolak, Truls Sylvan Ingebrigtsen, Jørgen Vestbo, Jacob Louis Marott
BACKGROUND: Long-term prognosis of patients with characteristics of both chronic obstructive pulmonary disease (COPD) and asthma, named asthma-COPD overlap, is poorly described. We investigated the long-term prognosis of individuals with different types of chronic airway disease, with a special focus on individuals with asthma-COPD overlap. METHODS: We assigned participants from the Copenhagen City Heart Study into six subgroups: healthy never-smokers, ever-smokers without asthma and COPD, those with asthma with low cumulated smoking exposure and no airflow limitation, those with COPD, those with asthma-COPD overlap with asthma onset before the age of 40 years, and those with asthma-COPD overlap with asthma onset after the age of 40 years...
June 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27051098/tuberculosis-associated-pulmonary-hypertension-the-revelation-of-a-clinical-observation
#14
Parthasarathi Bhattacharyya, Dipanjan Saha, Pratyaya Deep Bhattacherjee, Soumen Kumar Das, Pinak Pani Bhattacharyya, Ratna Dey
BACKGROUND: Pulmonary tuberculosis is not listed as a cause of pulmonary hypertension (PH). Scanty information is available in the literature regarding this issue. METHODS: A group of patients with a history of pulmonary tuberculosis were diagnosed to have PH on the basis of a novel clinico-radio-echocardiographic criteria. Subdivided into two groups on the basis of the history of smoking, we looked for their demographic, spirometric, radiological characteristics along with the quality of life assessment...
March 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/26951192/biomarkers-of-early-chronic-obstructive-pulmonary-disease-copd-in-smokers-and-former-smokers-protocol-of-a-longitudinal-study
#15
Mikael Truedsson, Johan Malm, K Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E Fehniger, György Marko-Varga
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD: in fact, most develop some amount of pulmonary impairment. Smoking-related COPD is associated with both acute exacerbations and is closely correlated to comorbidities, such as cardiovascular disease and lung cancer. The objective of our study (KOL-Örestad) is to identify biomarkers in smokers and ex-smokers, with early signs of COPD, and compare these biomarkers with those of non-smokers and healthy smokers/ex-smokers...
March 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/26932696/association-of-tumor-necrosis-factor-alpha-and-lymphotoxin-alpha-gene-polymorphisms-with-the-presence-of-chronic-obstructive-pulmonary-disease
#16
Amira P Tarigan, Tamsil Syafiuddin, Faisal Yunus, Suradi
AIM: to analyze the occurrence of chronic obstructive pulmonary disease (COPD) and its association with the polymorphisms of -308G/A, -238G/A of TNF gene and +252A/G LT gene polymorphism in smokers. METHODS: cross-sectional study, comparing the genetic group of people who have COPD and who do not have COPD with the same smoking history. The study was conducted from January 2011 to March 2012 at several health centers; such as Adam Malik Hospital, Pirngadi Hospital, Tembakau Deli Hospital, Siti Hajar Hospital in Medan and several health centers in the city of Medan...
October 2015: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/26836939/airway-centered-fibroelastosis-a-distinct-entity
#17
Pauline Pradere, Clément Gauvain, Claire Danel, Marie Pierre Debray, Raphael Borie, Laurent Plantier, Hervé Mal, Michel Aubier, Bruno Crestani, Camille Taillé
OBJECTIVE: To describe a new entity characterized by airway-centered fibroelastosis. METHODS: We identified cases with prominent airway-centered elastosis in lung samples, and little or no pleural involvement identified through a pathologic database at a single institution over an 8-year period. RESULTS: Airway-centered fibroelastosis was characterized by (1) extensive airway-centered fibroelastosis of the upper lobes on histopathology and (2) marked bronchial abnormalities with bronchial wall thickening, bronchial wall deformation, and bronchiectasis, along with progressive parenchymal retraction and predominantly subpleural upper-lobe consolidations on high-resolution CT...
March 2016: Chest
https://www.readbyqxmd.com/read/26806496/-ventilatory-function-in-patients-with-silicosis-or-coal-workers-pneumoconiosis
#18
Petr Brhel, Markéta Petrovová, Dana Lorenzová
OBJECTIVES: The aim of the study was to determine ventilatory function in a group of patients with silicosis and coal workers pneumoconisos (CWP) newly granted as occupational disease. METHODS: The authors have undertaken the analysis of all cases of occupational silicosis and CWP which were diagnosed in men in the South Moravia region. Information on ventilatory function, chest symptoms, age, working and smoking history was collected during the medical surveys, including spirometry testing and chest radiography...
December 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26788760/noncommunicable-lung-disease-in-sub-saharan-africa-a-community-based-cross-sectional-study-of-adults-in-urban-malawi
#19
Jamilah Meghji, Gilbert Nadeau, Kourtney J Davis, Duolao Wang, Moffat J Nyirenda, Stephen B Gordon, Kevin Mortimer
RATIONALE: Noncommunicable diseases are major causes of morbidity and mortality in sub-Saharan Africa (sSA). Valid burden of disease estimates are lacking for noncommunicable lung disease in sSA. OBJECTIVES: We performed a community-based survey to determine the prevalence of chronic lung disease among adults 18 years or older in Malawi, using American Thoracic Society standard spirometry, internationally validated respiratory symptom and exposure questionnaires, and an assessment of HIV status...
July 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26632766/interventions-for-smoking-cessation-in-people-diagnosed-with-lung-cancer
#20
REVIEW
Linmiao Zeng, Xiaolian Yu, Tingting Yu, Jianhong Xiao, Yushan Huang
BACKGROUND: Lung cancer is one of the most common causes of death from cancer worldwide. Smoking induces and aggravates many health problems, including vascular diseases, respiratory illnesses and cancers. Tobacco smoking constitutes the most important risk factor for lung cancer. Most people with lung cancer are still active smokers at diagnosis or frequently relapse after smoking cessation. Quitting smoking is the most effective way for smokers to reduce the risk of premature death and disability...
December 3, 2015: Cochrane Database of Systematic Reviews
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