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https://www.readbyqxmd.com/read/28733539/cancer-antigen-15-3-platelet-distribution-width-and-fibrinogen-in-combination-to-distinguish-breast-cancer-from-benign-breast-disease-in-non-conclusive-mammography-patients
#1
Shuang Fu, Zhi-Yuan Yun, Ming-Ming Cui, Hongxue Meng, Cheng Qian, Tiemin Liu, Zhi-Ping Liu, Rui-Tao Wang, Kai-Jiang Yu
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. However, mammographic diagnosis is sometimes non-conclusive with a Breast imaging Reporting and Data System (Bi-RaDS) result of 0. Cancer antigen 15-3 (CA15-3) is the most widely used serum tumor marker for breast cancer screening. Platelet distribution width (PDW) is an early indicator of platelet activation. Fibrinogen contributed to angiogenesis and distant metastasis. The aim of this study was to investigate the ability of CA15-3, PDW, and fibrinogen individually or in combination, to distinguish breast cancer from benign breast disease...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28727561/a-cots-based-microwave-imaging-system-for-breast-cancer-detection
#2
Mario R Casu, Marco Vacca, Jorge A Tobon, Azzurra Pulimeno, Imran Sarwar, Raffaele Solimene, Francesca Vipiana
Microwave imaging is an emerging breast cancer diagnostic technique, which aims at complementing already established methods like mammography, magnetic resonance imaging, and ultrasound. It offers two striking advantages: no-risk for the patient and potential low-cost for national health systems. So far, however, the prototypes developed for validation in labs and clinics used costly lab instruments such as a vector network analyzer (VNA). Moreover, the CPU time required by complex image reconstruction algorithms may not be compatible with the duration of a medical examination...
July 18, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28726117/applying-a-new-bilateral-mammographic-density-segmentation-method-to-improve-accuracy-of-breast-cancer-risk-prediction
#3
Shiju Yan, Yunzhi Wang, Faranak Aghaei, Yuchen Qiu, Bin Zheng
PURPOSE: How to optimally detect bilateral mammographic asymmetry and improve risk prediction accuracy remains a difficult and unsolved issue. Our aim was to find an effective mammographic density segmentation method to improve accuracy of breast cancer risk prediction. METHODS: A dataset including 168 negative mammography screening cases was used. We applied a mutual threshold to bilateral mammograms of left and right breasts to segment the dense breast regions...
July 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28724046/breast-cancer-screening-in-brazil-barriers-related-to-the-health-system
#4
René Aloisio da Costa Vieira, Alessandro Formenton, Silvia Regina Bertolini
Objective: Identify factors related to the health system that lead to a late diagnosis of breast cancer in Brazil. Method: We performed a systematic review in the PubMed and LILACS databases using as keywords "Breast cancer," "system of health" and "Brazil or Brasil." We evaluated the content of the articles using the PRISMA methodology based on PICTOS. The final date was 12/16/2015. We were able to identify 94 publications in PubMed and 43 publications in LILACS...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28721328/dramatic-regression-of-a-fungating-breast-lesion-treated-with-radiation-therapy
#5
Robert W Gao, Shane Edlund, Jianling Yuan
Although advances in screening mammography have dramatically improved the early detection of breast cancer, a subset of breast cancer cases still present as locally advanced disease. Some of these patients develop fungating lesions, which are difficult to manage and can have a severe impact on the quality of life. Palliative treatment options include surgery, intra-arterial chemotherapy, and radiation therapy. Herein, we describe the case of a patient who presented with a fungating breast mass and demonstrated an immediate and durable response to radiation therapy with a significantly improved quality of life...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28717699/opportunistic-breast-cancer-education-and-screening-in-rural-honduras
#6
Linda S Kennedy, Suyapa A Bejarano, Tracy L Onega, Derek S Stenquist, Mary D Chamberlin
PURPOSE: In Honduras, the breast cancer burden is high, and access to women's health services is low. This project tested the connection of community-based breast cancer detection with clinical diagnosis and treatment in a tightly linked and quickly facilitated format. METHODS: The Norris Cotton Cancer Center at Dartmouth College partnered with the Honduran cancer hospital La Liga Contra el Cancer to expand a cervical cancer screening program, which included self-breast exam (SBE) education and clinical breast exams (CBEs), to assess patient attitudes about and uptake of breast cancer education and screening services...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717658/targeting-breast-cancer-outcomes-what-about-the-primary-relatives
#7
Alison Johnston, Michael Sugrue
BACKGROUND: Up to 65% of newly diagnosed breast cancer patients had not been screened correctly before diagnosis resulting in increased stage of cancer at presentation. This study assessed whether their primary relatives are, in turn, assessed appropriately. METHODS: An ethically approved prospective study involving 274 primary relatives of women diagnosed with breast cancer, between 2009-2012, at a symptomatic breast unit in Ireland. Telephone interview established: demographics, menstrual history, family history verification, breast screening history...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28716454/a-randomised-trial-of-screening-with-digital-breast-tomosynthesis-plus-conventional-digital-2d-mammography-versus-2d-mammography-alone-in-younger-higher-risk-women
#8
Anthony J Maxwell, Michael Michell, Yit Y Lim, Susan M Astley, Mary Wilson, Emma Hurley, D Gareth Evans, Anthony Howell, Asif Iqbal, John Kotre, Stephen Duffy, Julie Morris
INTRODUCTION: Digital breast tomosynthesis (DBT) has been shown to increase invasive cancer detection rates at screening compared to full field digital (2D) mammography alone, and some studies have reported a reduction in the screening recall rate. No prospective randomised studies of DBT have previously been published. This study compares recall rates with 2D mammography with and without concurrent DBT in women in their forties with a family history of breast cancer undergoing incident screening...
June 30, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28714442/content-validity-of-a-screening-instrument-for-breast-cancer-early-detection-among-asian-american-women-the-cultural-health-and-screening-mammography-belief-scale
#9
Meng Zhao, Patricia L Conard
BACKGROUND AND PURPOSE: Asian American women have the lowest mammography screening rate in the United States. There is no standardized instrument available to measure their cultural beliefs regarding screening mammography. The purpose of this study is to evaluate the content validity of the Cultural Health and Screening Mammography Belief Scale (CHSMBS) developed for this population. Procedures for Instrument Development: The content validity was examined using content validity index (CVI)...
December 1, 2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28713499/relationship-among-mammographic-findings-with-histopathologic-type-of-breast-cancer-and-human-epidermal-growth-factor-receptor-2-her2-in-young-women
#10
Donya Farrokh, Samineh Boloursaz, Fatemeh Homai
INTRODUCTION: Radiological measures to diagnose breast cancer, including mammographic and ultrasound assessments in young women, are associated with restrictions affecting the use of this tool. No adequate information is available on mammography view in young people with breast cancer and its relationship with pathologic type and epidermal growth factor receptor 2 (HER2) as a prognostic marker, especially in the Iranian race. This study was conducted to examine the relationship between mammographic findings of young women with breast cancer with diagnosed histopathologic type and HER2 marker status...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28712610/the-hiqa-s-health-technology-assessment-of-breast-screening-highlighting-some-of-the-challenges-posed-by-evaluations-of-screening-programs
#11
Conor Teljeur, Patrick Moran, Patricia Harrington, Máirín Ryan
A review of the Health Information and Quality Authority's (HIQA) assessment of breast cancer surveillance cancer criticized how the results were presented and interpreted. The health technology assessment (HTA) investigated surveillance options for women aged less than 50 years who were at elevated risk of breast cancer. Surveillance strategies using digital mammography, magnetic resonance imaging, or a combination of the two modalities were modeled on the basis of diagnostic test accuracy. The HTA faced a number of issues, including the use of diagnostic test accuracy as a surrogate for long-term outcomes; modeling interventions that were not considered acceptable to clinicians; and extrapolating for screening intervals and age ranges not directly supported by available evidence...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28709150/mammography-and-ultrasound-effective-features-in-differentiating-basal-like-and-normal-like-subtypes-of-triple-negative-breast-cancer
#12
Zeng Zeng, Chun Jie Hou, Qiao Hong Hu, Ying Liu, Ceng Wang, Ran Wei, Xiao Ming Fan
The aim of our study was to find effective features of mammography and ultrasound in differentiating Basal-like breast cancer (BBC) and Normal-like breast cancer (NBC), two subtypes of triple negative breast cancer (TNBC). From January 2014 to March 2017, we retrospectively reviewed 91 patients who were pathologically confirmed as TNBC. According to immunohistochemical cytokeratin 5/6 (CK5/6) and Epidermal Growth Factor Receptor (EGFR), TNBCs were classified into BBCs group and NBCs group. Both CK5/6 and EGFR were negative defined to be NBC, whereas if any of CK5/6 or EGFR was positive then defined as BBC...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28707529/interpretation-of-digital-breast-tomosynthesis-preliminary-study-on-comparison-with-picture-archiving-and-communication-system-pacs-and-dedicated-workstation
#13
Young Seon Kim, Jung Min Chang, Ann Yi, Sung Ui Shin, Myung Eun Lee, Won Hwa Kim, Nariya Cho, Woo Kyung Moon
OBJECTIVES: To compare the diagnostic accuracy and efficiency in the interpretation of digital breast tomosynthesis (DBT) images using picture archiving and communication system (PACS) and a dedicated workstation. METHODS: A total of 97 DBT images performed for screening or diagnostic purposes were stored in both a workstation and PACS, and evaluated in combination with digital mammography by three independent radiologists retrospectively. Breast Imaging Reporting and Data System final assessments and likelihood of malignancy (%) were assigned and the interpretation time when using the workstation and PACS was recorded...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28706892/primary-osteosarcoma-of-the-breast-a-case-report
#14
Chan Seok Yoon, Sung Soo Kang
Primary osteosarcomas of the breast are extremely uncommon. Here we describe a case of a 77-year-old woman who presented with a hard mass on her right breast. Mammography and breast ultrasound demonstrated a round-shaped calcified mass on the right breast but the features were not definitely diagnostic. For diagnostic purposes, an excisional biopsy was performed and the mass proved to be a primary osteosarcoma of the breast by pathologic findings. PET-CT and whole body bone scan showed neither evidence of metastasis nor underlying bone lesions...
July 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28706406/health-related-factors-associated-with-adherence-to-breast-cancer-screening
#15
Joke Schoofs, Katrien Krijger, Jan Vandevoorde, Dirk Devroey
INTRODUCTION: In Belgium, an effective preventive program for breast cancer exists but as in many countries to few women participates in the screening. This study aims to describe the factors that affect the participation in the national breast cancer screening program. METHODS: The participants were aged between 50 and 69 years and were recruited during an exhibition at the Brussels Exhibition Centre. Medical history and health-related parameters of the participants were recorded...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28704430/does-lack-of-resources-impair-access-to-breast-and-cervical-cancer-screening-in-japan
#16
Hiroshi Sano, Rei Goto, Chisato Hamashima
OBJECTIVES: To assess the impact of the quantity of resources for breast and cervical cancer screening on the participation rates in screening in clinical settings in municipalities, as well as to clarify whether lack of resources impairs access to cancer screening in Japan. METHODS: Of the 1,746 municipalities in 2010, 1,443 (82.6%) and 1,469 (84.1%) were included in the analyses for breast and cervical cancer screening, respectively. In order to estimate the effects of the number of mammography units and of gynecologists on the participation rates in breast and cervical cancer screening in clinical settings, multiple regression analyses were performed using the interaction term for urban municipalities...
2017: PloS One
https://www.readbyqxmd.com/read/28702891/predictors-associated-with-mri-surveillance-screening-in-women-with-a-personal-history-of-unilateral-breast-cancer-but-without-a-genetic-predisposition-for-future-contralateral-breast-cancer
#17
John V Hegde, Xiaoyan Wang, Deanna J Attai, Maggie L DiNome, Amy Kusske, Anne C Hoyt, Sara A Hurvitz, Joanne B Weidhaas, Michael L Steinberg, Susan A McCloskey
PURPOSE: For women with a personal history of breast cancer (PHBC), no validated mechanisms exist to calculate future contralateral breast cancer (CBC) risk. The Manchester risk stratification guidelines were developed to evaluate CBC risk in women with a PHBC, primarily for surgical decision making. This tool may be informative for the use of MRI screening, as CBC risk is an assumed consideration for high-risk surveillance. METHODS: Three hundred twenty-two women with a PHBC were treated with unilateral surgery within our multidisciplinary breast clinic...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28702770/oncologic-outcomes-after-treatment-for-mri-occult-breast-cancer-pt0n
#18
Damian P McCartan, Emily C Zabor, Monica Morrow, Kimberly J Van Zee, Mahmoud B El-Tamer
BACKGROUND: Studies assessing outcomes in occult breast cancer have often included women treated before the routine use of magnetic resonance imaging (MRI). This study examined outcomes for patients presenting with axillary adenopathy and no primary breast tumor detectable by MRI or other imaging methods. METHODS: All patients with axillary nodal metastases consistent with breast carcinoma and no breast primary tumor detectable by physical exam, mammography, or MRI treated between 1 January 1996 and 30 June 2011 were identified from an institutional database...
July 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28699130/cost-effectiveness-of-risk-reducing-mastectomy-versus-surveillance-in-brca-mutation-carriers-with-a-history-of-ovarian-cancer
#19
Charlotte Gamble, Laura J Havrilesky, Evan R Myers, Junzo P Chino, Scott Hollenbeck, Jennifer K Plichta, P Kelly Marcom, E Shelley Hwang, Noah D Kauff, Rachel A Greenup
BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with BRCA1/2 mutations following stage II-IV ovarian cancer. DESIGN: We constructed a decision model from a third-party payer perspective to compare annual screening with magnetic resonance imaging (MRI) and mammography to annual screening followed by RRM with reconstruction following ovarian cancer diagnosis...
July 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28696192/breast-cancer-screening-does-tomosynthesis-augment-mammography
#20
REVIEW
Traci A Takahashi, Christoph I Lee, Kay M Johnson
Digital breast tomosynthesis (DBT) is a relatively new imaging technology that is being adopted widely for breast cancer screening. Initial evidence suggests that it may reduce recall rates and increase cancer detection rates when added to digital mammography screening. However, more rigorous, prospective studies are needed to determine whether it improves long-term clinical outcomes of breast cancer screening.
July 2017: Cleveland Clinic Journal of Medicine
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