Wujun Chen, Jiazhen Xu, Yudong Wu, Bing Liang, Mingzhe Yan, Chuandong Sun, Dong Wang, Xiaokun Hu, Li Liu, Wenchao Hu, Yingchun Shao, Dongming Xing
Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D, DHCR7, IDI1/2. Especially, HMGCR, SQLE, FDFT1, LSS, FDPS, CYP51, and EBP are promising therapeutic targets for drug development due to many drugs have been approved and entered into clinical research by targeting these genes. However, new targets and drugs still need to be discovered...
2023: International Journal of Biological Sciences