keyword
https://read.qxmd.com/read/38483907/astrocytes-control-recent-and-remote-memory-strength-by-affecting-the-recruitment-of-the-ca1%C3%A2-acc-projection-to-engrams
#1
JOURNAL ARTICLE
Ron Refaeli, Tirzah Kreisel, Tamar Ravins Yaish, Maya Groysman, Inbal Goshen
The maturation of engrams from recent to remote time points involves the recruitment of CA1 neurons projecting to the anterior cingulate cortex (CA1→ACC). Modifications of G-protein-coupled receptor pathways in CA1 astrocytes affect recent and remote recall in seemingly contradictory ways. To address this inconsistency, we manipulated these pathways in astrocytes during memory acquisition and tagged c-Fos-positive engram cells and CA1→ACC cells during recent and remote recall. The behavioral results were coupled with changes in the recruitment of CA1→ACC projection cells to the engram: Gq pathway activation in astrocytes caused enhancement of recent recall alone and was accompanied by earlier recruitment of CA1→ACC projecting cells to the engram...
March 13, 2024: Cell Reports
https://read.qxmd.com/read/38301148/empyema-secondary-to-pneumonia-whom-should-we-operate
#2
JOURNAL ARTICLE
Daniel Lichtenstein, Vadim Smolyakov, Yael Refaely, Ibrahim Mashni, Li Or Lazar, Guy Pines
Introduction: Empyema secondary to pneumonia is a common condition. A significant number of patients will require surgical intervention for drainage and decortication. The aim of this study was to identify predictive factors for surgical intervention. Materials and Methods: The medical records of patients who were diagnosed with empyema secondary to pneumonia between the years 2010 and 2019 in a university hospital were included in the study. Patients who underwent surgical intervention were defined as group A and nonoperative treatment as group B...
February 1, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38280198/analyzing-engram-reactivation-and-long-range-connectivity
#3
JOURNAL ARTICLE
Ron Refaeli, Tirzah Kreisel, Inbal Goshen
Here, we present a protocol for marking engram cells to efficiently measure reactivation levels and their projection pathways. We describe steps for genetic manipulation utilizing transgenic mice and viral infections, labeling engram cells, and a modified version of CLARITY, a tissue-clearing technique. This protocol can be adapted to various research inquiries that involve assessing the overlap of cell populations and uncovering novel long-range connectivity pathways. For complete details on the use and execution of this protocol, please refer to Refaeli et al...
January 25, 2024: STAR protocols
https://read.qxmd.com/read/38224275/assessment-of-long-noncoding-rna-ccat1-using-real-time-polymerase-chain-reaction-in-colorectal-cancer-patients
#4
JOURNAL ARTICLE
Amal A Mahmoud, Hanan O Mohamed, Mahmoud R Shehata, Alyaa A S Refae, Mostafa H Abd El Salam, Mohamed I Seddik
Colorectal cancer (CRC) is linked to high mortality, mainly when discovered in its advanced stages. Several studies have pointed to the role of epigenetic factors in CRC and other cancers. Long non-coding RNAs (lncRNAs) are involved in the initiation, progression, metastasis, and modulation of the response to chemotherapeutic modalities of CRC as vital contributors to epigenetic mechanisms. Colon cancer-associated transcript-1 (CCAT1) is one of the lncRNAs that have been dysregulated in serum samples, providing a non-invasive route for diagnosing CRC patients...
January 2024: Egyptian Journal of Immunology
https://read.qxmd.com/read/38101088/supporting-the-transition-to-parenthood-a-systematic-review-of-empirical-studies-on-emotional-and-psychological-interventions-for-first-time-parents
#5
REVIEW
Lee Barel Refaeli, Mariana Rodrigues, Annaliese Neaman, Nina Bertele, Yair Ziv, Anat Talmon, Yael Enav
OBJECTIVES: The transition to parenthood can evoke a range of concerns in parents, profoundly impacting their psychological well-being. The literature regarding the transition to parenthood focuses primarily on functional aspects of parenthood, generally overlooking the psychological well-being of parents. METHOD: This comprehensive review synthesized studies describing emotional and psychological interventions during the transition to parenthood among participants between 2013 and 2022...
December 1, 2023: Patient Education and Counseling
https://read.qxmd.com/read/38054904/photovoltage-and-photocurrent-absorption-spectra-of-sulfur-vacancies-locally-patterned-in-monolayer-mos-2
#6
JOURNAL ARTICLE
Alexander Hötger, Wolfgang Männer, Tomer Amit, Daniel Hernangómez-Pérez, Takashi Taniguchi, Kenji Watanabe, Ursula Wurstbauer, Jonathan J Finley, Sivan Refaely-Abramson, Christoph Kastl, Alexander W Holleitner
We report on the optical absorption characteristics of selectively positioned sulfur vacancies in monolayer MoS2 , as observed by photovoltage and photocurrent experiments in an atomistic vertical tunneling circuit at cryogenic and room temperature. Charge carriers are resonantly photoexcited within the defect states before they tunnel through an hBN tunneling barrier to a graphene-based drain contact. Both photovoltage and photocurrent characteristics confirm the optical absorption spectrum as derived from ab initio GW and Bethe-Salpeter equation approximations...
December 6, 2023: Nano Letters
https://read.qxmd.com/read/38031573/return-to-work-following-brachial-plexus-injury-a-cross-sectional-study
#7
JOURNAL ARTICLE
Hazel Brown, Kate Kennard, Rosalyn Tyreman, Ali Alim-Marvasti, Matthew Wilcox, Tom Quick
BACKGROUND: Qualitative studies following Brachial Plexus Injury (BPI) suggest that return to employment has a major influence on life satisfaction and psychological well-being. However, few studies have focused on return to work following BPI. The physical strain and intensity of an occupation may influence the ability of an individual to return to employment. This study aimed to provide information about the impact of workload intensity on employment status following BPI. METHODS: This is an observational, retrospective study of 74 participants who responded to a postal questionnaire, sharing information regarding their employment status pre- and post-BPI...
December 2023: Hand Therapy
https://read.qxmd.com/read/37844013/post-synthetic-ensembling-design-of-hierarchically-ordered-fau-type-zeolite-frameworks-for-vacuum-gas-oil-hydrocracking
#8
JOURNAL ARTICLE
Rajesh Kumar Parsapur, Amol M Hengne, Georgian Melinte, Omer Refa Koseoglu, Robert Peter Hodgkins, Anissa Bendjeriou-Sedjerari, Zhiping Lai, Kuo-Wei Huang
Zeolites hold importance as catalysts and membranes across numerous industrial processes that produce most of the world's fuels and chemicals. In zeolite catalysis, the rate of molecular diffusion inside the micropore channels defines the catalyst longevity and selectivity, thereby influencing the catalytic process efficiency. Decreasing the diffusion pathlengths of zeolites to the nanoscopic level by fabricating well-organized nanoporous architecture can efficiently overcome their intrinsic mass-transfer limitations without losing hydrothermal stability...
October 16, 2023: Angewandte Chemie
https://read.qxmd.com/read/37586373/engram-stability-and-maturation-during-systems-consolidation
#9
JOURNAL ARTICLE
Ron Refaeli, Tirzah Kreisel, Maya Groysman, Adar Adamsky, Inbal Goshen
Remote memories play an important role in how we perceive the world, and they are rooted throughout the brain in "engrams": ensembles of cells that are formed during acquisition. Upon their reactivation, a specific memory can be recalled.1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 Many studies have focused on the ensembles in CA1 of the hippocampus and the anterior cingulate cortex (ACC). However, the evolution of these components during systems' consolidation has not yet been comprehensively addressed...
September 25, 2023: Current Biology: CB
https://read.qxmd.com/read/37471020/widening-the-care-gap-an-international-comparison-of-care-leaving-in-the-time-of-covid-19
#10
JOURNAL ARTICLE
Tehila Refaeli, Noam Schuman-Harel, Eavan Brady, Varda R Mann-Feder, Emily R Munro, Adrian D van Breda
Following COVID-19, young people who transitioned to adulthood from different types of alternative care (care leavers) experienced an exacerbation of the challenges they had before the pandemic. The purpose of this international survey was to explore the range of policy and service responses that have or have not been implemented around the world to support care leavers during COVID-19. Responses were collected from care-leaving researchers from 19 countries toward the end of 2020. Half of the participating countries reported that the state had issued directives about measures that should be taken to support care leavers following COVID-19 outbreak, but only three reported actual changes in legislation...
July 20, 2023: American Journal of Orthopsychiatry
https://read.qxmd.com/read/37348129/reduced-absorption-due-to-defect-localized-interlayer-excitons-in-transition-metal-dichalcogenide-graphene-heterostructures
#11
JOURNAL ARTICLE
Daniel Hernangómez-Pérez, Amir Kleiner, Sivan Refaely-Abramson
Associating atomic vacancies to excited-state transport phenomena in two-dimensional semiconductors demands a detailed understanding of the exciton transitions involved. We study the effect of such defects on the electronic and optical properties of WS2 -graphene and MoS2 -graphene van der Waals heterobilayers, employing many-body perturbation theory. We find that chalcogen defects and the graphene interface radically alter the optical properties of the transition-metal dichalcogenide in the heterobilayer, due to a combination of dielectric screening and the many-body nature of defect-induced intralayer and interlayer optical transitions...
June 22, 2023: Nano Letters
https://read.qxmd.com/read/37328099/factors-affecting-duration-of-inability-to-work-after-intramedullary-stabilization-of-displaced-midshaft-clavicular-fractures
#12
JOURNAL ARTICLE
Ronny Langenhan, Milena Trifunovic Koenig, Axel Probst, Anica Kilper, Stefan Bushuven, Ludwig Schütz, Niklas Reimers
BACKGROUND: Duration of inability to work (DIW) after displaced midshaft clavicular fractures (DMCF) is an important clinical and socioeconomic treatment outcome. However, evidence on DIW after DMCF intramedullary stabilization (IMS) is still limited. We aimed to examine DIW and to identify medical and socioeconomic predictors with direct or indirect impact on DIW after IMS of DMCF. HYPOTHESIS: Socioeconomic predictors can explain the unique proportion of the DIW variance after IMS of DMCF above the variance explained by medical predictors...
June 14, 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/37182398/prevalence-of-preoperative-metabolic-disturbances-in-elderly-patients-with-hip-fracture-and-their-association-with-mortality-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
E Refaeli, S Zarour, Y Lior, M Herut, V Rabkin, M Aharonov, T Ben-Tov, B Cohen, I Matot
STUDY OBJECTIVES: To assess the prevalence of preoperative acidosis and lactatemia in elderly patients having hip fracture surgery and their association with post-operative mortality. DESIGN: Retrospective cohort study. SETTING: Single tertiary medical center. PATIENTS: Patients ≥65 years having first traumatic hip fracture surgery between 2018 and 2021. MEASUREMENTS: 90-day postoperative mortality...
September 2023: Journal of Clinical Anesthesia
https://read.qxmd.com/read/37110465/mpox-patient-journey-in-israel
#14
JOURNAL ARTICLE
Tal Patalon, Galit Perez, Yaki Saciuk, Ziva Refaeli, Sivan Gazit
Reports on Mpox have, thus far, characterized the disease, but mostly through a single timepoint view. The aim of this study was to characterize Mpox in the Israeli setting, in general, alongside compiling a detailed patient journey from multiple in-depth interviews with infected individuals. This descriptive study followed two complimentary paths: retrospective and prospective. The first consisted of interviews with Mpox patients, while the retrospective part included the retrieval of anonymized electronic medical records of patients diagnosed with Mpox between May and November 2022...
April 16, 2023: Microorganisms
https://read.qxmd.com/read/36650610/exploring-the-factors-impacting-physicians-attitudes-toward-health-information-exchange-with-patients-in-jordanian-hospitals
#15
JOURNAL ARTICLE
Emad Dahiyat, Faris El-Dahiyat, Ghaleb El Refae, Zaheer-Ud-Din Babar
BACKGROUND: The uniqueness of the physician-patient relationship and the latter's lack of medical experience and knowledge necessitate providing patients with accurate and timely information necessary to engage them in treatment decision-making. Without detailed information from their physicians, patients cannot understand their medical condition, assess treatment options, and participate meaningfully in their care. OBJECTIVES: The present research determines the main factors influencing physicians' attitudes toward health information exchange with patients in Jordanian hospitals...
January 17, 2023: Journal of Pharmaceutical Policy and Practice
https://read.qxmd.com/read/36521930/human-cd19-specific-switchable-car-t-cells-are-efficacious-as-constitutively-active-car-t-cells-but-cause-less-morbidity-in-a-mouse-model-of-human-cd19-malignancy
#16
JOURNAL ARTICLE
Christopher A Pennell, Heather Campbell, Meghan D Storlie, Sara Bolivar-Wagers, Mark J Osborn, Yosef Refaeli, Michael Jensen, Sophie Viaud, Travis S Young, Bruce R Blazar
Current Food and Drug Administration (FDA)-approved CD19-specific chimeric antigen receptor (CAR) T-cell therapies for B-cell malignancies are constitutively active and while efficacious, can cause morbidity and mortality. Their toxicities might be reduced if CAR T-cell activity was regulatable rather than constitutive. To test this, we compared the efficacies and morbidities of constitutively active (conventional) and regulatable (switchable) CAR (sCAR) T-cells specific for human CD19 (huCD19) in an immune-competent huCD19+ transgenic mouse model...
December 2022: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/36465851/mechanism-of-action-of-orthosiphon-stamineus-against-non-alcoholic-fatty-liver-disease-insights-from-systems-pharmacology-and-molecular-docking-approaches
#17
JOURNAL ARTICLE
Salah Abdulrazak Alshehade, Raghdaa Hamdan Al Zarzour, Vikneswaran Murugaiyah, Sharoen Yu Ming Lim, Huda Ghaleb El-Refae, Mohammed Abdullah Alshawsh
UNLABELLED: Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver. Orthosiphon stamineus also known as Orthosiphon aristatus is a medicinal plant with possible potential beneficial effects on various metabolic disorders. This study aims to investigate the in vitro inhibitory effects of O. stamineus on hepatic fat accumulation and to further use the computational systems pharmacology approach to identify the pharmacokinetic properties of the bioactive compounds of O...
November 2022: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/36389326/thoracic-surgery-in-israel
#18
REVIEW
Ory Wiesel, Yael Refaely, Daniel Fink
During the past 74 years since its establishment, Israel has evolved into a modernized country with well-established and effective public health care system. Thoracic surgeons in Israel play a central role in the diagnosis and treatment of patients with diseases of the chest wall, diaphragm, mediastinum, airways, Lung, and esophagus as well are taking part in designated trauma teams. Between 2,500-3,000 cases are being performed in 16 designated thoracic surgical units and departments across the country annually, the majority of them being performed in a minimally invasive fashion...
October 2022: Journal of Thoracic Disease
https://read.qxmd.com/read/36294218/the-use-of-mobile-health-interventions-for-outcomes-among-middle-aged-and-elderly-patients-with-prediabetes-a-systematic-review
#19
REVIEW
Yaltafit Abror Jeem, Russy Novita Andriani, Refa Nabila, Dwi Ditha Emelia, Lutfan Lazuardi, Hari Koesnanto
BACKGROUND: There are currently limited systematic reviews of mobile health interventions for middle-aged and elderly patients with prediabetes from trial studies. This review aimed to gather and analyze information from experimental studies investigating the efficacy of mobile health usability for outcomes among middle-aged and elderly patients with prediabetes. METHODS: We conducted a literature search in five databases: Clinicaltrials.gov, the International Clinical Trials Registry Platform (ICTRP), PubMed, ProQuest, and EBSCO, with a date range of January 2007 to July 2022 written in English, following a registered protocol on PROSPERO (CRD42022354351)...
October 20, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36141678/exploring-the-multidimensional-participation-of-adults-living-in-the-community-in-the-chronic-phase-following-acquired-brain-injury
#20
JOURNAL ARTICLE
Aviva Beit Yosef, Nirit Refaeli, Jeremy M Jacobs, Jeffrey Shames, Yafit Gilboa
This exploratory study aimed to examine multiple aspects of the participation of adults in the chronic phase following acquired brain injury (ABI), considering different disability levels. Our study included 25 adults ≥6 months after ABI (predominantly stroke), living at home, without severe cognitive decline. Primary measures included the Canadian Occupational Performance Measure (subjective participation) and the Mayo-Portland Adaptability Inventory-4 Participation Index (objective participation). The results indicated subjective participation problems in all of the International Classification of Functioning, Disability and Health participation domains...
September 10, 2022: International Journal of Environmental Research and Public Health
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