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https://www.readbyqxmd.com/read/27621456/tuning-electronic-transport-via-hepta-alanine-peptides-junction-by-tryptophan-doping
#1
Cunlan Guo, Xi Yu, Sivan Refaely-Abramson, Lior Sepunaru, Tatyana Bendikov, Israel Pecht, Leeor Kronik, Ayelet Vilan, Mordechai Sheves, David Cahen
Charge migration for electron transfer via the polypeptide matrix of proteins is a key process in biological energy conversion and signaling systems. It is sensitive to the sequence of amino acids composing the protein and, therefore, offers a tool for chemical control of charge transport across biomaterial-based devices. We designed a series of linear oligoalanine peptides with a single tryptophan substitution that acts as a "dopant," introducing an energy level closer to the electrodes' Fermi level than that of the alanine homopeptide...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27606697/extended-anti-her2-therapy-in-early-breast-cancer-longer-beats-shorter
#2
Sadal Refae, Barbara Pistilli, Suzette Delaloge
PURPOSE OF REVIEW: One-year duration of adjuvant trastuzumab is the gold standard since 2005. During the last decade many attempts have been made to both increase and reduce the treatment duration. The purpose of this article is to review the current available evidence regarding alternative anti-HER2 therapy durations in the (neo)adjuvant treatment of HER2-positive localized breast cancer patients. RECENT FINDINGS: According to the majority of published data, shorter trastuzumab schedule has shown a decreased benefit in the overall HER2 population, whereas extending adjuvant trastuzumab, beyond 1 year, does not improve the outcome and is associated with increased cardiac toxicity...
November 2016: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27602795/therapists-recognition-of-alliance-ruptures-as-a-moderator-of-change-in-alliance-and-symptoms
#3
Roei Chen, Dana Atzil-Slonim, Eran Bar-Kalifa, Ilanit Hasson-Ohayon, Eshkol Refaeli
: Therapists' awareness of ruptures in the alliance may determine whether such ruptures will prove beneficial or obstructive to the therapy process. OBJECTIVE: This study investigated the associations between therapists' recognition of these ruptures, and changes in clients' alliance ratings and symptom reports, using time-series data in a naturalistic treatment setting. METHOD: Eighty-four clients treated by 56 therapists completed alliance measures after each session, and the clients also completed symptom measures at the beginning of each session...
September 7, 2016: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/27587540/humanized-mouse-xenograft-models-narrowing-the-tumor-microenvironment-gap
#4
REVIEW
J Jason Morton, Gregory Bird, Yosef Refaeli, Antonio Jimeno
Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The development of highly immunodeficient mouse strains into which human immune systems can be engrafted can help bridge this gap. Humanized mice (HM) allow researchers to examine xenograft growth in the context of a human immune system and resultant tumor microenvironment, and recent studies have highlighted the increased similarities in attendant tumor structure, metastasis, and signaling to those features in cancer patients...
November 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27271983/personal-and-environmental-predictors-of-depression-among-victims-of-intimate-partner-violence-comparison-of-immigrant-and-israeli-born-women
#5
Tehila Refaeli, Drorit Levy, Anat Ben-Porat, Rachel Dekel, Haya Itzhaky
In the present study, ecological theory was used as a basis for predicting depression among women who survive intimate partner violence (IPV). The predictors examined in the study derived from three ecological systems: the microsystem (background variables and frequency of the violence), the ontogenic system (personal resources), and the mesosystem (support resources). One hundred twenty-five women who immigrated from the Former Soviet Union and 149 Israeli-born Jewish women filled in questionnaires when they entered shelters for victims of IPV...
June 5, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27046831/setd7-controls-intestinal-regeneration-and-tumorigenesis-by-regulating-wnt-%C3%AE-catenin-and-hippo-yap-signaling
#6
Menno J Oudhoff, Mitchell J S Braam, Spencer A Freeman, Denise Wong, David G Rattray, Jia Wang, Frann Antignano, Kimberly Snyder, Ido Refaeli, Michael R Hughes, Kelly M McNagny, Michael R Gold, Cheryl H Arrowsmith, Toshiro Sato, Fabio M V Rossi, John H Tatlock, Dafydd R Owen, Peter J Brown, Colby Zaph
Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal cancers, while dysregulation of the Hippo/Yes-Associated Protein (YAP) pathway is an emerging regulator of intestinal tumorigenesis. In addition, these closely related pathways play a central role during intestinal regeneration. We have previously shown that methylation of the Hippo transducer YAP by the lysine methyltransferase SETD7 controls its subcellular localization and function...
April 4, 2016: Developmental Cell
https://www.readbyqxmd.com/read/26988554/anterior-versus-posterior-debridement-fusion-for-single-level-dorsal-tuberculosis-the-role-of-graft-type-and-level-of-fixation-on-determining-the-outcome
#7
Yasser M Assaghir, Hesham Hamed Refae, Mohamed Alam-Eddin
PURPOSE: This study compared the clinical, radiological and functional outcome of anterior versus posterior approaches for single-level dorsal tuberculosis with analysis of effect of graft type and fixation level on the outcome. METHODS: Anterior group (AG): 43 cases (mean age: 49.5 years) fixed with Z-plate by anterior transthoracic-transpleural approach. Posterior group (PG): 49 cases (47.0 years) fixed with transpedicular-screws with unilateral facetectomy ± pediculectomy...
March 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/26958982/structure-based-engineering-of-lithium-transport-capacity-in-an-archaeal-sodium-calcium-exchanger
#8
Bosmat Refaeli, Moshe Giladi, Reuben Hiller, Daniel Khananshvili
Members of the Ca(2+)/cation exchanger superfamily (Ca(2+)/CA) share structural similarities (including highly conserved ion-coordinating residues) while exhibiting differential selectivity for Ca(2+), Na(+), H(+), K(+), and Li(+). The archaeal Na(+)/Ca(2+) exchanger (NCX_Mj) and its mammalian orthologs are highly selective for Na(+), whereas the mitochondrial ortholog (NCLX) can transport either Li(+) or Na(+) in exchange with Ca(2+). Here, structure-based replacement of ion-coordinating residues in NCX_Mj resulted in a capacity for transporting either Na(+) or Li(+), similar to the case for NCLX...
March 29, 2016: Biochemistry
https://www.readbyqxmd.com/read/26916536/cold-denaturation-induces-inversion-of-dipole-and-spin-transfer-in-chiral-peptide-monolayers
#9
Meital Eckshtain-Levi, Eyal Capua, Sivan Refaely-Abramson, Soumyajit Sarkar, Yulian Gavrilov, Shinto P Mathew, Yossi Paltiel, Yaakov Levy, Leeor Kronik, Ron Naaman
Chirality-induced spin selectivity is a recently-discovered effect, which results in spin selectivity for electrons transmitted through chiral peptide monolayers. Here, we use this spin selectivity to probe the organization of self-assembled α-helix peptide monolayers and examine the relation between structural and spin transfer phenomena. We show that the α-helix structure of oligopeptides based on alanine and aminoisobutyric acid is transformed to a more linear one upon cooling. This process is similar to the known cold denaturation in peptides, but here the self-assembled monolayer plays the role of the solvent...
2016: Nature Communications
https://www.readbyqxmd.com/read/26871539/-intramedullary-stabilisation-of-displaced-midshaft-clavicular-fractures-in-heavy-workers-and-complex-fracture-pattern
#10
R Langenhan, A Hecht, S Bushuven, N Reimers, A Probst
BACKGROUND: The medical literature recommends plate osteosynthesis (PO) for complex displaced midshaft clavicular fractures (DMCF) OTA type 15B3 and for heavy workers with displaced clavicular fractures. Recovery of DMCF treated with intramedullary stabilisation (IMS) will be examined and compared to published data for duration of inability to work (DIW) after conservative treatment as well as after PO, with respect to the DIW. PATIENTS AND METHODS: Between 09/2009 and 07/2015, the DIW of 58 patients (8 f, 50 m, mean age 38...
June 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/26693363/deep-neck-infection-and-descending-mediastinitis-as-a-complication-of-propionibacterium-acnes-odontogenic-infection
#11
Evgeni Brotfain, Leonid Koyfman, Lisa Saidel-Odes, Abraham Borer, Yael Refaely, Moti Klein
Propionibacterium acnes is an anaerobic, Gram-positive bacterium which causes numerous types of infections. Isolated Propionibacterium acnes deep neck infections are very rare. We present an interesting case of deep neck infection complicated by descending mediastinitis of isolated Propionibacterium acnes infection.
2015: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/26657264/return-to-sports-activity-and-work-after-autologous-chondrocyte-implantation-of-the-knee-which-factors-influence-outcomes
#12
Jan M Pestka, Matthias J Feucht, Stella Porichis, Gerrit Bode, Norbert P Südkamp, Philipp Niemeyer
BACKGROUND: Autologous chondrocyte implantation (ACI) has been associated with satisfying results in everyday activities. Clinical results after ACI treatment of femorotibial lesions are superior in comparison with patellofemoral lesions. There is limited information regarding at which level recreational, amateur, and professional athletes can resume sports and physical activities as well as work after ACI and what parameters influence return to work and sports. HYPOTHESIS: Return to sports activity and work is dependent on defect characteristics such as location and size...
February 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26319758/molecular-cytogenetics-of-pediatric-adipocytic-tumors
#13
REVIEW
Bérengère Dadone, Sadal Refae, Camille Lemarié-Delaunay, Laurence Bianchini, Florence Pedeutour
Both epidemiologic and cytogenetic data on pediatric adipose tissue tumors are scarce. Pediatric adipose tumors are mainly represented by lipomas, though only 28 cytogenetic descriptions of pediatric lipoma have been reported to date. Similar to adult cases, most of these pediatric lipomas harbored rearrangements of the chromosomal regions 12q14-q15 and 6p21, involving the HMGA2 and HMGA1 genes. Further cytogenetic studies of pediatric lipoma would be useful to determinate whether some partner genes of HMGA2, such as NFIB, may have a specific role in the early onset of these tumors...
October 2015: Cancer Genetics
https://www.readbyqxmd.com/read/26272582/incapacity-of-work-after-arthroscopic-bankart-repair
#14
Tobias M Kraus, Thomas Freude, Sebastian Fiedler, Steffen Schröter, Ulrich Stöckle, Atesch Ateschrang
BACKGROUND AND INTRODUCTION: The incapacity with respect to work following anterior-inferior shoulder dislocation and subsequent Bankart repair has not been previously examined. The objective of this study was to examine a patient's incapacity according to the classification by the REFA Association. The recovery time was measured and the outcome of patients with heavy workload was compared to those with lower workloads. MATERIALS AND METHODS: A total of 74 patients who underwent isolated arthroscopic Bankart repair fulfilled the inclusion criteria...
October 2015: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/26149234/electronic-transport-via-homopeptides-the-role-of-side-chains-and-secondary-structure
#15
Lior Sepunaru, Sivan Refaely-Abramson, Robert Lovrinčić, Yulian Gavrilov, Piyush Agrawal, Yaakov Levy, Leeor Kronik, Israel Pecht, Mordechai Sheves, David Cahen
Many novel applications in bioelectronics rely on the interaction between biomolecules and electronically conducting substrates. However, crucial knowledge about the relation between electronic transport via peptides and their amino-acid composition is still absent. Here, we report results of electronic transport measurements via several homopeptides as a function of their structural properties and temperature. We demonstrate that the conduction through the peptide depends on its length and secondary structure as well as on the nature of the constituent amino acid and charge of its residue...
August 5, 2015: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/25997592/towards-a-standardized-rapid-ecosystem-function-assessment-refa
#16
REVIEW
Sebastian T Meyer, Christiane Koch, Wolfgang W Weisser
Quantifying ecosystem functioning is important for both fundamental and applied ecological research. However, there is currently a gap between the data available and the data needed to address topical questions, such as the drivers of functioning in different ecosystems under global change or the best management to sustain provisioning of ecosystem functions and services. Here, we identify a set of important functions and propose a Rapid Ecosystem Function Assessment (REFA). The proposed methods were specifically selected to be low-tech, easy to use, repeatable, and cost efficient...
July 2015: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/25784673/readiness-for-independent-living-among-youth-on-the-verge-of-leaving-juvenile-correctional-facilities
#17
Eran Melkman, Tehila Refaeli, Batya Bibi, Rami Benbenishty
A growing body of literature has documented the dismal outcomes of youth placed in juvenile correctional facilities (JCFs) upon their return to the community. However, very little is known as to how well equipped are the youth with the necessary skills for reintegration. In the current study, the authors examine self-reports of readiness for independent living among adolescents in correctional settings on the verge of leaving care, and explore how individual, placement, and social support characteristics predict such perceived readiness...
August 2016: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/25300396/clinical-outcome-and-return-to-work-following-single-stage-combined-autologous-chondrocyte-implantation-and-high-tibial-osteotomy
#18
Gerrit Bode, Peter Ogon, Jan Pestka, Jörn Zwingmann, Matthias Feucht, Norbert Südkamp, Philipp Niemeyer
PURPOSE: Concomitant unloading procedures, such as high tibial osteotomy (HTO), are increasingly recognized as an important part of cartilage repair. This study presents survival rate, functional outcome, complication rate, and return to work following combined single-stage autologous chondrocyte implantation (ACI) and HTO. METHODS: Forty patients with a mean follow-up of 60 months with isolated full thickness cartilage defects of the medial femoral condyle (MFC) and concomitant varus deformity were included in this retrospective case series...
April 2015: International Orthopaedics
https://www.readbyqxmd.com/read/25170611/expansion-of-human-and-murine-hematopoietic-stem-and-progenitor-cells-ex-vivo-without-genetic-modification-using-myc-and-bcl-2-fusion-proteins
#19
Gregory A Bird, Avital Polsky, Patricia Estes, Teri Hanlon, Haley Hamilton, John J Morton, Jonathan Gutman, Antonio Jimeno, Brian C Turner, Yosef Refaeli
The long-term repopulating hematopoietic stem cell (HSC) population can self-renew in vivo, support hematopoiesis for the lifetime of the individual, and is of critical importance in the context of bone marrow stem cell transplantation. The mechanisms that regulate the expansion of HSCs in vivo and in vitro remain unclear to date. Since the current set of surface markers only allow for the identification of a population of cells that is highly enriched for HSC activity, we will refer to the population of cells we expand as Hematopoietic Stem and Progenitor cells (HSPCs)...
2014: PloS One
https://www.readbyqxmd.com/read/24960094/-duration-of-inability-for-work-and-return-to-physical-work-after-arthroscopic-and-open-labrum-refixation
#20
A Ateschrang, S Fiedler, S Schröter, U Stöckle, T Freude, T M Kraus
BACKGROUND AND INTRODUCTION: The duration of inability for work according to work load and the rate of successful return to work after open and arthroscopic Bankart repair (BR) due to anterior shoulder dislocation has not yet been examined with regard to validated work strain by the REFA classification. Thus, the objective of this study was to determine the duration of inability to work according to work load (REFA criteria) after open and arthroscopic BR as well as the rate of successful return to the original occupation...
June 2014: Zeitschrift Für Orthopädie und Unfallchirurgie
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