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https://www.readbyqxmd.com/read/28164754/prevalence-of-adverse-drug-reactions-to-highly-active-antiretroviral-therapy-haart-among-hiv-positive-patients-in-imam-khomeini-hospital-of-tehran-iran
#1
Raheleh Golrokhy, Hamid Emadi Koochak, Azita Babaii, Alia Pourdast, Mehrnaz Rasoolinejad, Saeed Reza Jamali Moghadam, Reza Rezaei Taheri, Seyed Ahmad SeyedAlinaghi
OBJECTIVE: The present study assessed the prevalence of adverse drug reactions (ADRs) among HIV positive patients referred to Imam Khomeini hospital in Tehran, Iran. METHODS: This is a cross sectional study regarding side effects of Highly Active Antiretroviral Therapy (HAART) in HIV positive patients referred to Voluntary Counseling and Testing (VCT) center in Imam Khomeini Hospital of Tehran, Iran during a period of the year 2009 to 2010. Two hundred patients under antiretroviral treatment evaluated for the side effects of drug based on available records, face to face interviews and written lab data...
January 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28163136/safety-and-effectiveness-of-a-12-week-course-of-sofosbuvir-and-simeprevir%C3%A2-%C3%A2-%C3%A2-ribavirin-in-hcv-infected-patients-with-or-without-hiv-infection-a-multicentre-observational-study
#2
Giuseppe Bruno, Annalisa Saracino, Claudia Fabrizio, Luigia Scudeller, Eugenio Milano, Raffaele Dell'Acqua, Nicoletta Ladisa, Massimo Fasano, Salvatore Minniti, Giovanni Buccoliero, Alessandra Tartaglia, Adele Giammario, Michele Milella, Gioacchino Angarano
The combination of sofosbuvir and simeprevir ± ribavirin (SOF + SMV ± RBV) for hepatitis C virus (HCV) treatment has been associated with high rates of sustained virological response (SVR). Few data are available regarding this regimen in HIV/HCV co-infected patients. This study evaluated the effectiveness and safety of a 12-week course of SOF + SMV ± RBV in a cohort of HCV monoinfected and HIV/HCV co-infected individuals. HCV-infected patients, with or without HIV infection, receiving a 12-week course of SOF + SMV ± RBV in four Italian centres from February to October 2015, were included in this retrospective observational study...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28128730/infectious-zika-virus-in-vaginal-secretions-from-an-hiv-infected-woman-france-august-2016
#3
Pauline Penot, Ségolène Brichler, Jean Guilleminot, Caroline Lascoux-Combe, Olivier Taulera, Emmanuel Gordien, Isabelle Leparc-Goffart, Jean-Michel Molina
A woman with controlled HIV infection developed in late August 2016 a pruritic rash with fever and conjunctival hyperaemia after a trip to the French Caribbean islands. On day 3 after symptom onset, Zika virus RNA was detected in plasma, urine and vaginal samples with respective viral loads of 3.8, 6.1 and 5.3 log copies/mL. Notably, we demonstrated the presence of infectious Zika virus particles in the vaginal samples by isolation in cell culture.
January 19, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28127144/a-nodular-ulcerative-form-of-secondary-syphilis-in-aids
#4
Ofelya Gevorgyan, Benjamin D Owen, Arvind Balavenkataraman, Mitchell R Weinstein
An uncommon variant in the pre-AIDS era, lues maligna is a nodular-ulcerative form of secondary syphilis. We present a case of a 41-year-old man with HIV infection who developed fever, chills, nausea, vomiting, right upper quadrant abdominal pain, weight loss, watery diarrhea, and a painless, nonpruritic rash. He had diffuse nodular-ulcerative lesions in various stages of development. He was found to have a CD4 count of 101 cells/mm(3) (22%), an HIV viral load of 2,735,060 copies/mL, and a positive rapid plasma reagin at 1:64...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28126366/testing-for-zika-virus-infection-in-pregnancy-key-concepts-to-deal-with-an-emerging-epidemic
#5
REVIEW
Catherine Eppes, Martha Rac, James Dunn, James Versalovic, Kristy O Murray, Melissa A Suter, Magda Sanz Cortes, Jimmy Espinoza, Maxim D Seferovic, Wesley Lee, Peter Hotez, Joan Mastrobattista, Steven L Clark, Michael A Belfort, Kjersti M Aagaard
Zika virus is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Following epidemics in Micronesia and French Polynesia during the past decade, more recent Zika virus infection outbreaks were first reported in South America as early as May 2013 and spread to now 50 countries throughout the Americas. Although no other flavivirus has previously been known to cause major fetal malformations following perinatal infection, reports of a causal link between Zika virus and microcephaly, brain and ocular malformations, and fetal loss emerged from hard-hit regions of Brazil by October 2015...
January 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28120645/neisseria-meningitidis-serogroup-c-sepsis-and-septic-arthritis-in-an-hiv-positive-man
#6
A Fox-Lewis, C P Eades, J J Manson, S Morris-Jones, R F Miller
A patient with well-controlled HIV-1 infection presented with fever and rigors, a widespread maculopapular rash, and severe generalised arthralgia. Sepsis of unknown aetiology was diagnosed, and treatment with broad-spectrum antimicrobials commenced. Following initial clinical improvement, a right knee septic arthritis developed. Microscopy and culture of the joint aspirate were negative for organisms but 16S rDNA PCR identified Neisseria meningitidis DNA, subsequently verified as capsular genogroup C, thus confirming a diagnosis of disseminated meningococcal sepsis with secondary septic arthritis...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28119485/plasma-cytokines-and-chemokines-in-zambian-children-with-measles-innate-responses-and-association-with-hiv-1-co-infection-and-in-hospital-mortality
#7
Wen-Hsuan W Lin, Ashley Nelson, Judith J Ryon, William J Moss, Diane E Griffin
To identify immune factors present during the acute rash phase of measles and associations with outcome and HIV-1 co-infection, we measured the plasma levels of 22 cytokines and chemokines in Zambian children hospitalized with measles (N=148) and control children (N=44). Children with measles had higher levels of innate cytokines TNF-α , IL-1β , IL-18 and IL-6; chemokines CCL2, CCL4, CCL11, CCL22, CXCL8 and CXCL10; and T cell cytokines IFN-γ , IL-2, IL-10 and IL-17. Children who died in-hospital had higher levels of TNF-α , IL-1β , IL-12p70; CCL2, CCL4, CCL13, CCL17, CXCL8, CXCL10; IL-2 and IFN-γ and lower levels of IL-4, than children who survived...
January 24, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28035758/genotypic-tropism-testing-of-proviral-dna-to-guide-maraviroc-initiation-in-aviraemic-subjects-48-week-analysis-of-results-from-the-protest-study
#8
E Poveda, J Hernández-Quero, M J Pérez-Elías, M A Ribas, O J Martínez-Madrid, J Flores, J Navarro, F Gutiérrez, M García-Deltoro, A Imaz, A Ocampo, A Artero, F Blanco, E Bernal, J Pasquau, C Mínguez-Gallego, N Pérez, A Aiestaran, F García, R Paredes
OBJECTIVES: Maraviroc (MVC) is a suitable drug for aviraemic subjects on antiretroviral treatment (ART) developing toxicity. Its prescription requires prior tropism testing. It is unknown if proviral DNA genotypic tropism testing is reliable for guiding MVC initiation in aviraemic subjects, so this study was carried out to address this issue. METHODS: PROTEST was a phase 4, prospective, single-arm clinical trial carried out in 24 HIV care centres in Spain. MVC-naïve HIV-1-infected patients with HIV-1 RNA < 50 copies/mL on stable ART during the previous 6 months who required an ART change because of toxicity and who had R5 HIV, as determined by proviral DNA genotypic tropism testing, initiated MVC with two nucleoside reverse transcriptase inhibitors (NRTIs) and were followed for 48 weeks...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27989875/ethnobotany-phytochemistry-toxicology-and-pharmacological-properties-of-terminalia-sericea-burch-ex-dc-combretaceae-a-review
#9
REVIEW
N I Mongalo, L J McGaw, T V Segapelo, J F Finnie, J Van Staden
ETHNOPHARMACOLOGICAL REFERENCE: The use of medicinal plants in the treatment of infections is ancient. A wide variety of ethnotherapeutic properties and pharmacological actions has been attributed to Terminalia sericea. Studies by various groups of investigators reveal that it is a multipurpose medicinal plant used mostly in the treatment of diarrhoea, sexually transmitted infections, skin rashes, tuberculosis and other infections. The current paper is aimed at providing an overview of the ethnomedicinal uses, toxicology, pharmacology and the phytochemistry of Terminalia sericea...
October 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27943261/efavirenz-or-nevirapine-in-three-drug-combination-therapy-with-two-nucleoside-or-nucleotide-reverse-transcriptase-inhibitors-for-initial-treatment-of-hiv-infection-in-antiretroviral-na%C3%A3-ve-individuals
#10
REVIEW
Lawrence Mbuagbaw, Sara Mursleen, James H Irlam, Alicen B Spaulding, George W Rutherford, Nandi Siegfried
BACKGROUND: The advent of highly active antiretroviral therapy (ART) has reduced the morbidity and mortality due to HIV infection. The World Health Organization (WHO) ART guidelines focus on three classes of antiretroviral drugs, namely nucleoside or nucleotide reverse transcriptase inhibitors (NRTI), non-nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors. Two of the most common medications given as first-line treatment are the NNRTIs, efavirenz (EFV) and nevirapine (NVP)...
10, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27929236/fever-and-rash-in-a-patient-with-hiv-infection
#11
Ari Konheim, Paula J Watts, Joselin D Tacastacas
No abstract text is available yet for this article.
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27834135/synthesis-and-biological-evaluation-of-benzophenone-derivatives-as-potential-hiv-1-inhibitors
#12
Zhendong Song, Ping Wang, Shanshan Huang, Changyuan Wang, Ruirui Wang, Liumeng Yang, Yuhong Zhen, Kexin Liu, Yongtang Zheng, Xiaodong Ma
BACKGROUND: Although a number of agents can achieve high response in acquired immunodeficiency syndrome (AIDS) patients, safer and more active HIV inhibitors are still needed for the growing number of patients infected with resistant HIV virus strains. GW678248, is one of the most potent benzophenone derivatives, exhibiting high potency against a panel of HIV-1 virus (wild-type, K103N mutant, Y181C, etc.) at 1 nM/L concentrations. However, the safety issues associated with rash and liver metabolic enzymes ultimately led to discontinue its further development...
November 11, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27761646/-viral-arthritis-and-vasculitis
#13
U Sixdorf, E Märker-Hermann
Viral arthritis and vasculitis are important differential diagnoses primarily in patients with acute polyarticular arthritis in association with fever and rash, in populations specially at risk and in returning travellers. Parvovirus B19 is the most frequent cause of viral arthritis in Europe, whereas rubella, hepatitis B and C viruses have become less common. Due to worldwide tourism arthritogenic alphaviruses, which are transmitted by mosquito vectors have come into the focus of tropical medicine and rheumatology...
November 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27747727/a-suspected-case-of-efavirenz-induced-stevens-johnson-syndrome
#14
Sabyasachi Paik, Agnik Pal, Sukanta Sen, Netai Pramanick, Santanu K Tripathi
A 23-year-old human immunodeficiency virus (HIV)-infected Indian woman was admitted to a tertiary care hospital with generalized erythematosus rash all over her body with difficulty in swallowing for the previous 3 days. She also presented with swelling of the lips and redness of both eyes along with nausea, anorexia, slight headache, and fever, which appeared immediately after the initiation of a new regime of antiretroviral treatment with tenofovir (300 mg once daily), lamivudine (300 mg once daily), and efavirenz (600 mg once daily)...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27716093/effectiveness-and-safety-of-generic-version-of-abacavir-lamivudine-and-efavirenz-in-treatment-na%C3%A3-ve-hiv-infected-patients-a-nonrandomized-open-label-phase-iv-study-in-cali-colombia-2011-2012
#15
Jaime Galindo, Pedro Amariles, Héctor F Mueses-Marín, Jaime A Hincapié, Sebastián González-Avendaño, Ximena Galindo-Orrego
BACKGROUND: Generic drug policies are often associated with concerns about the quality and effectiveness of these products. Phase IV clinical trials may be a suitable design to assess the effectiveness and safety of generic drugs. The objective of this study was to describe the effectiveness and the safety of the generic abacavir/lamivudine and efavirenz in treatment-naïve HIV-infected patients. METHODS: A monocentric, nonrandomized, open-label, phase IV study in treatment naïve HIV-infected patients 18 years or older with indication to receive abacavir/lamivudine and efavirenz were recruited from a program that provides comprehensive outpatient consultation and continuing care...
October 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27681148/adverse-drug-reactions-associated-with-antiretroviral-therapy-in-south-africa
#16
Sumeshni Birbal, Mukesh Dheda, Elizabeth Ojewole, Frasia Oosthuizen
South Africa has one of the highest prevalences of HIV and AIDS in the world. HIV/AIDS patients face countless challenges, one of which is the risk of adverse drug reactions (ADRs). This study aimed to describe the ADRs reported in South Africa with reference to the type of ADRs, antiretrovirals (ARVs) implicated, seriousness of the ADRs and patient demographics associated with specific ADRs. A retrospective quantitative study was carried out using ADR reports submitted to the National Department of Health (NDoH) from 1 January 2010 to 31 December 2014...
September 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27566775/immune-reconstitution-inflammatory-syndrome-associated-with-secondary-syphilis
#17
Simona Frunza-Stefan, Gyanendra Acharya, Viktoryia Kazlouskaya, Paunel Vukasinov, Yushan Chiou, Zeyar Thet
Immune reconstitution inflammatory syndrome (IRIS) is a condition associated with paradoxical worsening and/or new onset of an opportunistic infection in HIV patients following the initiation of anti-retroviral therapy or switching to more potent antiretroviral therapy (ART) regimen. Although IRIS associated with many opportunistic infections (OIs) has been well reported, syphilis has very rarely been mentioned in this regard. A 52-year-old male, diagnosed with AIDS six weeks ago, presented with the disseminated non-pruritic painless skin rash...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27565715/immunogenicity-of-trimethoprim-sulfamethoxazole-in-a-macaque-model-of-hiv-infection
#18
Yat Yee Wong, Eva G Rakasz, David J Gasper, Thomas C Friedrich, Lauren A Trepanier
BACKGROUND: Sulfonamide hypersensitivity has a high incidence in HIV infection and correlates with low CD4+ counts, but the mechanisms are not understood. The aims of this study were to determine whether trimethoprim/sulfamethoxazole (TMP/SMX) led to SMX adduct formation, immunogenicity, or signs of drug hypersensitivity in SIV-infected rhesus macaques, and whether differences in antioxidants, pro-inflammatory mediators, or SMX disposition were predictive of drug immunogenicity. METHODS: Nine macaques chronically infected with SIVmac239 and 7 non-infected controls were studied...
August 10, 2016: Toxicology
https://www.readbyqxmd.com/read/27530904/a-severe-hypersensitivity-reaction-to-abacavir-following-re-challenge
#19
Sej Todd, C R Emerson
We report this case to highlight the possibility of a severe hypersensitivity reaction as an important potential consequence of couples, living with HIV, sharing anti-retroviral treatment. An HIV-1 positive and carrier of HLA-B*57:01 allele, treatment experienced man was commenced one pill Regimen Stribild (tenofovir, emtricitabine, elvitegravir and cobicistat) in July 2015. On running short of medication, he admitted to sharing his partner's treatment (Triumeq; abacavir, lamivudine and dolutegravir). On the second occasion, re-introduction resulted in whole body rash 4 h post dose and was associated with fever, respiratory symptoms, headache and vomiting...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27516418/acquired-immune-deficiency-syndrome-in-differential-diagnosis-of-hyper-ige-immunoglobulinemia-pediatric-case-report
#20
Manolya Acar, Murat Sutcu, Ozge Umur, Hacer Akturk, Selda Hancerli Torun, Zeynep Tamay, Nuran Salman, Ayper Somer
Acquired immune deficiency syndrome can be encountered with hypereosinophilia and hyperimmunoglobulin E (hyper-IgE) values, though these levels are rarely so high to be compared with hyperimmunoglobulin E syndrome. A 9-year-old boy presented with the complaint of fatigue, weakness, weight loss and generalized pruritic rash lasting for a year. He had frequent respiratory tract infections, wheezing episodes and urticarial skin lesions before that. On admission, he was cachectic and he had generalized lymphadenopathy, hepatosplenomegaly, oral moniliasis and pruritic rash all over his body...
February 2017: Journal of Tropical Pediatrics
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