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https://www.readbyqxmd.com/read/27834135/synthesis-and-biological-evaluation-of-benzophenone-derivatives-as-potential-hiv-1-inhibitors
#1
Zhendong Song, Ping Wang, Shanshan Huang, Changyuan Wang, Ruirui Wang, Liumeng Yang, Yuhong Zhen, Kexin Liu, Yongtang Zheng, Xiaodong Ma
BACKGROUND: Although a number of agents can achieve high response in acquired immunodeficiency syndrome (AIDS) patients, safer and more active HIV inhibitors are still needed for the growing number of patients infected with resistant HIV virus strains. GW678248, is one of the most potent benzophenone derivatives, exhibiting high potency against a panel of HIV-1 virus (wild-type, K103N mutant, Y181C, etc.) at 1 nM/L concentrations. However, the safety issues associated with rash and liver metabolic enzymes ultimately led to discontinue its further development...
November 11, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27755121/vasculitis-in-the-autoinflammatory-diseases
#2
Hagit Peleg, Eldad Ben-Chetrit
PURPOSE OF REVIEW: This article addresses the prevalence and relationship between autoinflammatory diseases and vasculitis. RECENT FINDINGS: Autoimmune diseases (AIDs) are a group of syndromes characterized by episodes of unprovoked inflammation due to dysregulation of the innate immune system. Despite the common occurrence of rashes and other skin lesions in these diseases, vasculitis is reported in only a few. On the other hand, neutrophilic dermatoses are more prevalent...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27742713/a-woman-with-aids-and-a-neglected-disease-presenting-with-coma-periumbilical-purpuric-rash-and-alveolar-hemorrhage
#3
Bruno A Randi, Marília F Felício, Carolina S Lázari, Maria Irma S Duarte, Ilana Halpern, Yeh-Li Ho
No abstract text is available yet for this article.
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27742712/a-woman-with-aids-and-a-neglected-disease-presenting-with-coma-periumbilical-purpuric-rash-and-alveolar-hemorrhage
#4
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27681743/the-clinical-diagnosis-and-management-of-kawasaki-disease-a-review-and-update
#5
REVIEW
Frank H Zhu, Jocelyn Y Ang
Kawasaki disease is an acute, self-limited vasculitis of childhood and has become the leading cause of acquired pediatric heart disease in the USA. Prompt treatment is essential in reducing cardiac-related morbidity and mortality. The underlying etiology remains unknown. The disease itself may be the characteristic manifestation of a common pathway of immune-mediated vascular inflammation in susceptible hosts. The characteristic clinical features of fever for at least 5 days with bilateral nonpurulent conjunctivitis, rash, changes in lips and oral cavity, changes in peripheral extremities, and cervical lymphadenopathy remain the mainstay of diagnosis...
September 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27681148/adverse-drug-reactions-associated-with-antiretroviral-therapy-in-south-africa
#6
Sumeshni Birbal, Mukesh Dheda, Elizabeth Ojewole, Frasia Oosthuizen
South Africa has one of the highest prevalences of HIV and AIDS in the world. HIV/AIDS patients face countless challenges, one of which is the risk of adverse drug reactions (ADRs). This study aimed to describe the ADRs reported in South Africa with reference to the type of ADRs, antiretrovirals (ARVs) implicated, seriousness of the ADRs and patient demographics associated with specific ADRs. A retrospective quantitative study was carried out using ADR reports submitted to the National Department of Health (NDoH) from 1 January 2010 to 31 December 2014...
September 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27588834/early-clinical-features-in-systemic-lupus-erythematosus-can-they-be-used-to-achieve-earlier-diagnosis-a-risk-prediction-model
#7
Frances Rees, Michael Doherty, Peter Lanyon, Graham Davenport, Richard D Riley, Weiya Zhang, Matthew J Grainge
OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis. METHODS: 1,739 incident SLE cases practice-matched to 6,956 controls from the UK Clinical Practice Research Datalink. Odds ratios were calculated for age, gender, consultation rates, selected presenting clinical features and previous diagnoses in the 5 years preceding diagnosis date using logistic regression...
September 2, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27566775/immune-reconstitution-inflammatory-syndrome-associated-with-secondary-syphilis
#8
Simona Frunza-Stefan, Gyanendra Acharya, Viktoryia Kazlouskaya, Paunel Vukasinov, Yushan Chiou, Zeyar Thet
Immune reconstitution inflammatory syndrome (IRIS) is a condition associated with paradoxical worsening and/or new onset of an opportunistic infection in HIV patients following the initiation of anti-retroviral therapy or switching to more potent antiretroviral therapy (ART) regimen. Although IRIS associated with many opportunistic infections (OIs) has been well reported, syphilis has very rarely been mentioned in this regard. A 52-year-old male, diagnosed with AIDS six weeks ago, presented with the disseminated non-pruritic painless skin rash...
August 26, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27552432/congenital-brain-abnormalities-and-zika-virus-what-the-radiologist-can-expect-to-see-prenatally-and-postnatally
#9
Patricia Soares de Oliveira-Szejnfeld, Deborah Levine, Adriana Suely de Oliveira Melo, Melania Maria Ramos Amorim, Alba Gean M Batista, Leila Chimelli, Amilcar Tanuri, Renato Santana Aguiar, Gustavo Malinger, Renato Ximenes, Richard Robertson, Jacob Szejnfeld, Fernanda Tovar-Moll
Purpose To document the imaging findings associated with congenital Zika virus infection as found in the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil, where the congenital infection has been particularly severe. Materials and Methods From June 2015 to May 2016, 438 patients were referred to the IPESQ for rash occurring during pregnancy or for suspected fetal central nervous system abnormality. Patients who underwent imaging at IPESQ were included, as well as those with documented Zika virus infection in fluid or tissue (n = 17, confirmed infection cohort) or those with brain findings suspicious for Zika virus infection, with intracranial calcifications (n = 28, presumed infection cohort)...
October 2016: Radiology
https://www.readbyqxmd.com/read/27530754/outpatient-use-of-ceftaroline-fosamil-versus-vancomycin-for-osteoarticular-infection-a-matched-cohort-study
#10
Vasilios Athans, Rachel M Kenney, Jacob Wong, Susan L Davis
OBJECTIVES: There are few convenient intravenous options for long-term outpatient treatment of osteoarticular infection (OAI) and limited effectiveness and safety data exist for this off-label use of ceftaroline. The objective of this study was to describe the long-term effectiveness and safety of ceftaroline for the treatment of OAI. METHODS: This was a matched retrospective cohort study of patients receiving ceftaroline- or vancomycin-based therapy for OAI in the outpatient setting...
August 15, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27495916/the-abdominal-wall-transplant-as-a-sentinel-skin-graft
#11
James Barnes, Fadi Issa, Georgios Vrakas, Peter Friend, Henk Giele
PURPOSE OF REVIEW: Abdominal wall transplantation is a technique used to achieve abdominal closure after intestinal and multivisceral transplantation. This review focuses on whether there are additional benefits for the skin component as an immune-monitoring tool. RECENT FINDINGS: The largest series of abdominal wall transplants has recently been published. Alongside the physiological advantage gained in abdominal closure, the authors describe the immunological insight that the skin component can provide and how this contributes to the management of patients...
October 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27449226/treatment-satisfaction-in-a-randomized-clinical-trial-of-mhealth-smoking-abstinence-reinforcement
#12
Sheila M Alessi, Carla J Rash
The importance of patient satisfaction in modern healthcare is widely recognized, but research on satisfaction in the context of smoking cessation has not kept pace. The purpose of this study was to explore treatment satisfaction in a sample of smokers (N=84) randomized to one of two smoking cessation treatment interventions (mHealth reinforcement and mHealth monitoring) that used cell phone-based procedures to monitor smoking status in individuals' natural environments for 4 weeks. Starting on the target quit date, participants received usual care smoking cessation treatment consisting of 8 weeks of transdermal nicotine and 4 weeks of twice-weekly telephone counseling were also prompted 1 to 3 times daily (with exact number and timing not disclosed beforehand) to use a study cell phone and CO monitor to complete a CO self-test, video-record the process, and submit videos using multimedia messaging within 2 hours...
July 4, 2016: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/27227446/histoplasma-capsulatum-sinusitis-possible-way-of-revelation-to-the-disseminated-form-of-histoplasmosis-in-hiv-patients-case-report-and-literature-review
#13
R Elansari, R Abada, S Rouadi, M Roubal, M Mahtar
INTRODUCTION: Histoplasma capsulatum is rarely found in nose and sinuses in immunocompetent and even in immunosupressed patients. A literature review revealed rare cases of H. capsulatum sinusitis and the case we describe in this paper is the first case of H. capsulatum sinusitis in Morocco. The purpose of our work is to present a rare case of H. capsulatum sinusitis and a literature review. CASE REPORT: A male patient, at his 39 presented to the emergency with suffered from nasal congestion and yellow postnasal rhinorrhea, occasional headaches and epistaxis for over than two months...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27214289/muscle-biopsy-findings-in-combination-with-myositis-specific-autoantibodies-aid-prediction-of-outcomes-in-juvenile-dermatomyositis
#14
Claire T Deakin, Shireena A Yasin, Stefania Simou, Katie A Arnold, Sarah L Tansley, Zoe E Betteridge, Neil J McHugh, Hemlata Varsani, Janice L Holton, Thomas S Jacques, Clarissa A Pilkington, Kiran Nistala, Lucy R Wedderburn
OBJECTIVE: Juvenile dermatomyositis (DM) is a rare and severe autoimmune condition characterized by rash and proximal muscle weakness. While some patients respond to standard treatment, others do not. This study was carried out to investigate whether histopathologic findings and myositis-specific autoantibodies (MSAs) have prognostic significance in juvenile DM. METHODS: Muscle biopsy samples (n = 101) from patients in the UK Juvenile Dermatomyositis Cohort and Biomarker Study were stained, analyzed, and scored for severity of histopathologic features...
November 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27166033/pathologic-lesions-in-children-with-acquired-immunodeficiency-syndrome-an-autopsy-study-of-11-cases-from-mumbai-india
#15
Dhanesheshwar N Lanjewar, Varsha Omprakash Bhatia, Sonali Dhaneshwar Lanjewar
BACKGROUND: Human immunodeficiency virus (HIV) infection in India has now been prevalent over three decades, and an increasing number of children are being affected with HIV. The spectrum of pathologic lesions in children with acquired immunodeficiency syndrome (AIDS) in India has not been well described. MATERIALS AND METHODS: A review of systematically conducted autopsies of 11 (10 boys and 1 girl) children with AIDS is presented. RESULTS: The mode of HIV transmission in 6 children was vertical; in one it was blood transfusion and in 4 children route was presumably vertical as these were children of orphanage...
April 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27134114/drug-induced-hypersensitivity-syndrome-drug-reaction-with-eosinophilia-and-systemic-symptoms-dihs-dress-11-years-retrospective-study-in-thailand
#16
Akarin Hiransuthikul, Thanapoom Rattananupong, Jettanong Klaewsongkram, Pawinee Rerknimitr, Marisa Pongprutthipan, Kiat Ruxrungtham
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but life-threatening adverse drug reaction. Several criteria have been established to aid the diagnosis. However, patients with DRESS remained underdiagnosis and undertreatment. METHODS: Medical records of hospitalized patients at the King Chulalongkorn Memorial Hospital from January 2004-December 2014 due to DRESS were enrolled retrospectively using RegiSCAR diagnostic criteria...
April 28, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27073526/adult-dermatomyositis-associated-with-benign-ovarian-teratoma-a-case-report
#17
Xiaomin Yu, Dongyan Qin, Dehua Ma, Qin Yao
A 27-year-old female patient presented with a 3-month history of bilateral orbital and facial edema accompanied by skin erythema and heliotrope rash. The left lesion was more critical than the right. Limb muscles were occasionally sore. On physical examination, scattered hemorrhagic rashes were observed on the patient's face and neck. Upon laboratory testing, creatine kinase (CK) was markedly elevated at 1,543.2 U/l, while CK-MB isoenzyme (27.4 U/l), α-hydroxybutyric dehydrogenase (188.4 U/l) and aspartate aminotransferase (65...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/27025225/high-daily-doses-of-trimethoprim-sulfamethoxazole-are-an-independent-risk-factor-for-adverse-reactions-in-patients-with-pneumocystis-pneumonia-and-aids
#18
Hui-Min Chang, Hung-Chin Tsai, Susan Shin-Jung Lee, Calvin Kunin, Pei-Chin Lin, Shue-Ren Wann, Yao-Shen Chen
BACKGROUND: Trimethoprim/sulfamethoxazole (TMP/SMX) is currently the most effective therapeutic agent for Pneumocystis jirovecii pneumonia (PJP) in patients with AIDS. The major drawback is the frequent occurrence of adverse reactions (ADRs).The current study was designed to determine the frequency and risk factors for TMP/SMX-related ADRs among patients with PJP and AIDS. METHODS: A retrospective study was conducted in adult patients with PJP and AIDS who were admitted to the Veterans General Hospital in, Kaohsiung, Taiwan between January 2006 and December 2011...
June 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/26641498/association-of-extrahepatic-manifestations-with-autoimmune-hepatitis
#19
Guan Wee Wong, Michael A Heneghan
For many patients with autoimmune hepatitis (AIH), the presence of extrahepatic features is well recognised both at the time of presentation and during long-term follow-up. Concomitant 'autoimmune disorders' have been described in 20-50% of patients with AIH, both in adults and children. Indeed, the presence of these associated phenomena has been incorporated into both the original and revised International AIH group scoring systems as an aid to codifying the diagnosis. In acute index presentations, non-specific joint pains sometimes flitting in nature have been reported in 10-60% of patients, and while joint swelling is uncommon, rheumatoid arthritis and mixed connective tissue disease have been reported in 2-4% of patients with AIH...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/26585841/pediatric-necrolytic-migratory-erythema-as-a-presenting-sign-of-glucagonoma-syndrome
#20
A J Luber, L S Ackerman, K S Culpepper, C M Buschmann, L J Koep
Glucagonoma syndrome is an extremely rare pancreatic neuroendocrine tumor often associated with necrolytic migratory erythema. While glucagonomas are neoplasms of adulthood, we report the first case in a pediatric patient. We present the case of a 15-year-old female with a 4-year history of a rash, consistent with necrolytic migratory erythema, found to have a localized glucagonoma. Immediately following resection of the tumor, there was complete resolution of her rash and systemic symptoms. Detection of the cutaneous rash of necrolytic migratory erythema can aid in the early diagnosis of a glucagonoma as well as the prevention of metastatic disease...
November 20, 2015: British Journal of Dermatology
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