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https://www.readbyqxmd.com/read/26034748/radical-improvement-of-signs-and-symptoms-in-systemic-lupus-erythematosus-when-treated-with-hemodiafiltration-with-endogenous-reinfusion-dialysis
#1
Francesco Giuseppe Solano, Elisa Bellei, Aurora Cuoghi, Marialuisa Caiazzo, Francesco Bruni
Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). In the kidney, immune complexes and autoantibodies activate mesangial cells that secrete cytokines that can further amplify inflammatory processes. We present the case of a 42-year-old woman with lupus nephritis accompanied by periods of exacerbation of SLE, with necrotic-like skin lesions, psoriatic arthritis without skin psoriasis, purpura of the lower limb, petechial rash, joint pain, fever, eyelid edema with bilateral conjunctival hyperemia and itching...
January 2015: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/26011402/possible-role-of-proenkephalin-in-psoriasis
#2
N A Nagui, M A Ezzat, H M Abdel Raheem, L A Rashed, N A Abozaid
BACKGROUND: Psoriasis is a common chronic skin disease that can also affect the mucous membranes and joints. It is multifactorial in origin, occurring in genetically predisposed individuals, and triggered by various endogenous and exogenous factors. Proenkephalin (PENK) is an endogenous opioid polypeptide hormone that acts on specific opiate receptors found on nerve and mucosal cells, and on various cells in the immune system. PENK receptors are expressed on skin cells, and their activation can regulate keratinocyte and melanocyte activities...
March 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/24940500/phase-i-trial-of-m2es-a-novel-polyethylene-glycosylated-recombinant-human-endostatin-plus-gemcitabine-in-advanced-pancreatic-cancer
#3
Yang Chen, Yiqi DU, Ping Li, Fei Wu, Yan Fu, Zhaoshen Li, Yongzhang Luo
Pancreatic cancer is one of the most lethal and resistant to treatment of solid tumors. Combination therapies with various types of drugs against pancreatic cancer have been extensively investigated. Endostatin is a potent endogenous inhibitor of angiogenesis, which may be administered in combination with various chemotherapeutic agents in the treatment of several types of cancer. To the best of our knowledge, this phase I trial was the first clinical study to determine the tolerance, safety and efficacy of M2ES, a novel polyethylene glycosylated recombinant human endostatin, administered concurrently with full-dose gemcitabine in patients with inoperable, locally advanced or metastatic pancreatic adenocarcinoma...
July 2014: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/24091200/anaphylactic-shock-associated-with-intravenous-thrombolytics
#4
REVIEW
Amna Zarar, Asif A Khan, Malik M Adil, Adnan I Qureshi
Adverse events including intracerebral hemorrhage and reperfusion arrhythmias are well known to occur with thrombolytic therapy. We report a case report of anaphylactic reaction directly attributable to intravenous (IV) recombinant tissue plasminogen activator and identify additional cases through review of the Food and Drug Administration Adverse Event Reporting System. A systematic review of Adverse Event Reporting System was performed for allergic adverse events occurring in conjunction with IV thrombolytics...
January 2014: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/23112261/a-not-so-superficial-skin-infection-in-a-patient-with-diabetes
#5
James Michael Carr, Guy Hagan, Peter Guest, Simon Gompertz
A woman in her 60s with type 2 diabetes presented with a 4-week history of a rash on her chest wall, flu-like symptoms and a red right eye. On examination, there was a cellulitic rash over the right chest wall, breast and neck and a hypopyon in the right eye. Chest x-ray demonstrated right upper lobe opacification, with subsequent CT and MRI revealing bilateral collections at the lung apices, and a possible permeative bone destruction of the manubrium, respectively. A diagnosis of primary sternal osteomyelitis with associated lung abscesses, chest wall cellulitis and hypopyon due to endogenous endophthalmitis was made, with microbiological assessment identifying group B β-haemolytic streptococci...
2012: BMJ Case Reports
https://www.readbyqxmd.com/read/23106440/quantification-of-gly-m-4-protein-a-major-soybean-allergen-by-two-dimensional-liquid-chromatography-with-ultraviolet-and-mass-spectrometry-detection
#6
Samir Julka, Krishna Kuppannan, Anton Karnoup, Demetrius Dielman, Barry Schafer, Scott A Young
Soybean (Glycine max) is considered a major allergenic food. Gly m 4 is one of several soybean allergens that has been identified to cause an allergic reaction, typically the symptoms are localized effects including the skin, gastrointestinal tract, or respiratory tract. Soybean allergens are considered a complete food allergen in that they are capable of inducing specific IgE as well as eliciting a range of severity from mild rashes up to anaphylaxis. In this study, we have isolated, purified, and characterized an endogenous Gly m 4 protein...
November 20, 2012: Analytical Chemistry
https://www.readbyqxmd.com/read/22715821/downregulation-of-tlr-7-receptor-in-hepatic-and-non-hepatic-patients-with-lichen-planus
#7
Amira El Tawdy, Laila Rashed
BACKGROUND: Lichen planus (LP) is an inflammatory disease of the skin and oral mucosa. The association of LP and chronic hepatitis C virus (HCV) is well established, with variable prevalence rates among different populations. Toll-like receptors (TLRs) are key regulators of both the innate response and the adaptive response. However, TLRs also interact with endogenous ligands released by necrotic cells, and this process can intensify autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus...
July 2012: International Journal of Dermatology
https://www.readbyqxmd.com/read/21572809/a-case-series-of-kaposi-s-varicelliform-eruption-in-dermatology-in-patients-in-a-tertiary-care-centre
#8
Amiya Kumar Nath, Tukaram Sori, Devinder Mohan Thappa
BACKGROUND: Recently, we noted increasing number of cases of Kaposi's varicelliform eruption (KVE) among dermatology in-patients who were being treated for various dermatoses, some of which have not been reported earlier to be associated with KVE, and hence, this report. AIMS: This study was designed to identify various dermatoses in which KVE occurred, to study the clinical features, course and response to specific antiviral treatment, to establish the risk factors, and course of the primary dermatoses during the episode of KVE...
January 2011: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/20923247/pharmacokinetic-and-pharmacodynamic-perspectives-on-the-clinical-drug-development-of-panitumumab
#9
REVIEW
Bing-Bing Yang, Peggy Lum, Alin Chen, Rosalin Arends, Lorin Roskos, Brian Smith, Juan José Pérez Ruixo
Panitumumab is a recombinant, fully human IgG2 monoclonal antibody directed against the epidermal growth factor receptor (EGFR). It is indicated for use as monotherapy in the treatment of patients with EGFR-expressing metastatic colorectal cancer after disease progression with standard chemotherapy. The currently indicated dose is 6 mg/kg given every 2 weeks. Panitumumab is mainly distributed into the vascular space and exhibits nonlinear pharmacokinetics that are consistent with target-mediated drug disposition, involving saturable binding to EGFR and subsequent internalization and degradation inside the cells...
November 2010: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/20336051/acute-interstitial-nephritis
#10
REVIEW
Manuel Praga, Ester González
Acute interstitial nephritis (AIN) represents a frequent cause of acute kidney injury, accounting for 15-27% of renal biopsies performed because of this condition. By and large, drug-induced AIN is currently the commonest etiology of AIN, with antimicrobials and nonsteroidal anti-inflammatory drugs being the most frequent offending agents. Pathogenesis is based on an immunologic reaction against endogenous nephritogenic antigens or exogenous antigens processed by tubular cells, with cell-mediated immunity having a major pathogenic role...
June 2010: Kidney International
https://www.readbyqxmd.com/read/20179416/the-inflammasome-an-innate-immunity-guardian-participates-in-skin-urticarial-reactions-and-contact-hypersensitivity
#11
REVIEW
Naotomo Kambe, Yuumi Nakamura, Megumu Saito, Ryuta Nishikomori
Urticarial rash, one of the clinical manifestations characteristic of cryopyrin-associated periodic syndrome (CAPS), is caused by a mutation in the gene encoding for NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeats containing family, pyrin domain containing 3). This intracellular pattern recognition receptor and its adaptor protein, called apoptosis associated speck-like protein containing a caspase-recruitment and activating domain (ASC), participate in the formation of a multi-protein complex termed the inflammasome...
June 2010: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/20079456/nlrp3-an-immune-sensor-of-cellular-stress-and-infection
#12
REVIEW
Mohamed Lamkanfi, Thirumala-Devi Kanneganti
Innate immune cells rely on pathogen recognition receptors such as the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family to mount an appropriate immune response against microbial threats. The NLR protein Nlrp3 senses microbial ligands, endogenous danger signals and crystalline substances in the cytosol to trigger the assembly of a large caspase-1-activating protein complex termed the Nlrp3 inflammasome. Autoproteolytic maturation of caspase-1 zymogens in the Nlrp3 inflammasome leads to maturation and extracellular release of the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18...
June 2010: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/20046699/bilateral-endophthalmitis-as-the-initial-presentation-of-bacterial-meningitis
#13
Seong-Jae Kim, Seong Wook Seo, Jong-Moon Park, In-Young Chung
To report a case of bilateral endophthalmitis as the initial presentation of bacterial meningitis in a young, immunocompetent Korean patient. A 35-year-old female with a one day history of bilateral swollen eyes, visual disturbance, headache, petechial skin rash, and nausea visited our clinic. She was diagnosed as having endogenous endophthalmitis associated with bacterial meningitis. Intravenous broad spectrum antibiotic therapy was initiated with cefotaxime 3 g and ubacillin 3 g, four times daily. Intravitreal antibiotic (vancomycin 1 mg/0...
December 2009: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/19553630/herpes-zoster-pathogenesis-and-cell-mediated-immunity-and-immunosenescence
#14
REVIEW
Michael N Oxman
Herpes zoster, or shingles, is a localized disease characterized by unilateral radicular pain and a vesicular rash limited to the area of skin innervated by a single dorsal root or cranial sensory ganglion. Whereas varicella, or chickenpox, results from primary exogenous varicella-zoster virus (VZV) infection, herpes zoster is caused by reactivation of endogenous VZV that has persisted in latent form within sensory ganglia following an earlier episode of chickenpox. In contrast to recurrent herpes simplex, herpes zoster is commonly associated with severe pain: prodromal pain often precedes the rash by several days; pain usually accompanies the dermatomal rash of herpes zoster; and clinically significant pain and allodynia may persist for weeks, months, or even years after the herpes zoster rash has healed, a debilitating complication known as postherpetic neuralgia (PHN)...
June 2009: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/17958791/increased-expression-of-hmgb-1-in-the-skin-lesions-of-erythema-toxicum
#15
Giovanna Marchini, Kjell Hultenby, Annika Nelson, Elham Yektaei-Karin, Berit Ståbi, Solbritt Lonne-Rahm, Ann-Kristin Ulfgren, Hjalmar Brismar
At birth, commensal microbes penetrate into the skin of the human newborn, eliciting an acute rash, erythema toxicumn neonatorum. Histologically, the rash is characterized by an upregulation of proinflammatory activity and a local recruitment of immunocytes, including macrophages. High mobility group box chromosomal protein 1, a nuclear and cytosolic protein, is also a pro-inflammatory cytokine released by macrophages in response to microbial stimulation. Here, we reasoned that macrophages but also keratinocytes might upregulate this protein in response to the first colonization and that high mobility group box chromosomal protein 1 might play a role as a proinflammatory mediator in the development and progression of erythema toxicum...
September 2007: Pediatric Dermatology
https://www.readbyqxmd.com/read/15821783/cetuximab-an-epidermal-growth-factor-receptor-chemeric-human-murine-monoclonal-antibody
#16
REVIEW
Joanne Harding, Barbara Burtness
The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. It is composed of extracellular domains, including a ligand-binding domain, a hydrophobic transmembrane region and a tyrosine kinase-containing cytoplasmic region. Stimulation of the EGFR by endogenous ligands, EGF or transforming growth factor-alpha (TGF-alpha), results in a conformational change in the receptor, permitting it to enter into dimers and other oligomers. Dimerization results in activation of intracellular tyrosine kinase, protein phosphorylation and stimulation of various cell signaling pathways that mediate gene transcription and cell cycle progression...
February 2005: Drugs of Today
https://www.readbyqxmd.com/read/14700664/orbital-cellulitis-panophthalmitis-and-ecthyma-gangrenosum-in-an-immunocompromised-host-with-pseudomonas-septicemia
#17
Luke J Maccheron, Erwin R Groeneveld, Stephen J Ohlrich, David J Hilford, Peter S Beckingsale
PURPOSE: To describe a case of Pseudomonas aeruginosa septicemia complicated by orbital cellulitis, panophthalmitis, and ecthyma gangrenosum. DESIGN: Observational case report. METHODS: An immunosuppressed 62-year-old man developed an unusual skin rash and a painful, swollen right eye with decreased vision. He had myelodysplastic syndrome and P. aeruginosa septicemia. The skin rash manifested as ecthyma gangrenosum. Metastatic orbital cellulitis and panophthalmitis was diagnosed...
January 2004: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/14672050/-tuberculosis-in-compromised-hosts
#18
(no author information available yet)
Recent development of tuberculosis in Japan tends to converge on a specific high risk group. The proportion of tuberculosis developing particularly from the compromised hosts in the high risk group is especially high. At this symposium, therefore, we took up diabetes mellitus, gastrectomy, dialysis, AIDS and the elderly for discussion. Many new findings and useful reports for practical medical treatment are submitted; why these compromised hosts are predisposed to tuberculosis, tuberculosis diagnostic and remedial notes of those compromised hosts etc...
November 2003: Kekkaku: [Tuberculosis]
https://www.readbyqxmd.com/read/13783427/host-parasite-factors-in-group-a-streptococcal-infections-pyrogenic-and-other-effects-of-immunologic-distinct-exotoxins-related-to-scarlet-fever-toxins
#19
D W WATSON
The factors present in streptococcal lesion extracts (SLE) which enhanced the lethal and tissue-damaging properties of Gram-negative bacterial endotoxins and streptolysin O were identified with the scarlet fever group of toxins. Toxic manifestations attributed to this group of toxins included lethality, cardiotoxic and other tissue damage, enhancement of toxicity, and pyrogenicity. Of these, the measurement of febrile response in American Dutch rabbits was the most useful parameter of toxicity. In rabbits, repeated daily intravenous injections of 0...
February 1, 1960: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/12708096/-autochthonous-strongyloidosis-in-an-81-year-old-woman
#20
Tom Ziegler, Anja Schau, Christina Winkler
Strongyloidosis is an parasitic disease, caused by an intestinal nematode endemic in tropic and subtropic regions. In Central Europe it occurs only sporadically. The infective larvae in the soil penetrate the human skin. Following circulation through the lungs the larvae settle in the small intestine and mature into adult worms. Chronic strongyloidosis recurring up to 15 years is possible through endogenous autoinfection. Clinical feature of the disease are gastrointestinal symptoms, hypereosinophilia and skin rashes...
June 14, 2002: Wiener Klinische Wochenschrift
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