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https://www.readbyqxmd.com/read/29456939/outcomes-of-bone-anchored-hearing-aid-implant-at-universiti-kebangsaan-malaysia-medical-centre-ukmmc
#1
Suhana Abdul Rahim, Bee-See Goh, Safinaz Zainor, Roslenda Abdul Rahman, Asma Abdullah
The cross sectional study was conducted in Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia from August 2012 to December 2013. All patients implanted with in UKMMC from December 2001 until December 2012 was included. Glasgow Benefit Inventory (GBI) questionnaires and UKMMC questionnaires were used as part of the assessment tool. The GBI is a scoring which measures the change in health status produced by surgical interventions. UKMMC questionnaires was invented by our department to assess questions related to social and life style of patients and also the cosmetic perspective Baha implant and other daily related activities...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29452882/synthesis-characterisation-and-dna-intercalation-studies-of-regioisomers-of-ruthenium-ii-polypyridyl-complexes
#2
Laura Perdisatt, Samar Moqadasi, Luke O'Neill, Gary Hessman, Alessandra Ghion, Muhammad Qasim Mushtaq Warraich, Alan Casey, Christine O'Connor
Regioisomers of the functional group of the main ligand (L) on a series of [Ru(phen) 2 L] 2+ and [Ru(bpy) 2 L] 2+ complexes, where phen is 1,10 phenanthroline and bpy is 2,2'-bipyridine, were synthesised to investigate the interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV-Vis binding titrations, thermal denaturation and circular dichroism were used to evaluate their interaction with DNA. The conclusions indicated the significance of the auxiliary ligand; especially 1,10-phenanthroline has on the binding constants (K b )...
February 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29446015/synthetic-polymeric-biomaterials-for-wound-healing-a-review
#3
Mariam Mir, Murtaza Najabat Ali, Afifa Barakullah, Ayesha Gulzar, Munam Arshad, Shizza Fatima, Maliha Asad
Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the 'one size fits all approach', if it conforms strictly to the specifications of the wound and the patient...
February 14, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29441291/nail-biopsy-a-user-s-manual
#4
REVIEW
Chander Grover, Shikha Bansal
Nail biopsy is a procedure not routinely resorted to; but when indicated, it is often the only clue left for diagnosis. At such times, it pays to be conversant with it. It is an investigation that not only provides etiologic, diagnostic, and prognostic information but also aids in understanding the pathogenesis of nail diseases. It can be of therapeutic value, especially with respect to nail tumors. This article compiles the procedural techniques for nail biopsy of various types and attempts to summarize the evidence available in the literature...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29436037/parental-use-of-sun-protection-for-their-children-does-skin-color-matter
#5
Marcus G Tan, Shudeshna Nag, Miriam Weinstein
BACKGROUND/OBJECTIVES: Excessive sun exposure during childhood is a risk factor for skin cancer. This study aimed to compare the frequency of ideal sun protection use between parents with lighter- and darker-skinned children and explore their attitudes and beliefs on sun safety and their choice of sun protection. METHODS: Parents of children aged 6 months to 6 years completed self-administered questionnaires about sun protection practices for their children. Parents assessed their child's Fitzpatrick phototype and were divided into lighter- (Fitzpatrick phototype I-III) and darker-skinned (Fitzpatrick phototype IV-VI) groups...
February 13, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29426714/automated-analysis-and-classification-of-melanocytic-tumor-on-skin-whole-slide-images
#6
Hongming Xu, Cheng Lu, Richard Berendt, Naresh Jha, Mrinal Mandal
This paper presents a computer-aided technique for automated analysis and classification of melanocytic tumor on skin whole slide biopsy images. The proposed technique consists of four main modules. First, skin epidermis and dermis regions are segmented by a multi-resolution framework. Next, epidermis analysis is performed, where a set of epidermis features reflecting nuclear morphologies and spatial distributions is computed. In parallel with epidermis analysis, dermis analysis is also performed, where dermal cell nuclei are segmented and a set of textural and cytological features are computed...
February 6, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29426326/remote-photoplethysmography-with-constrained-ica-using-periodicity-and-chrominance-constraints
#7
Richard Macwan, Yannick Benezeth, Alamin Mansouri
BACKGROUND: Remote photoplethysmography (rPPG) has been in the forefront recently for measuring cardiac pulse rates from live or recorded videos. It finds advantages in scenarios requiring remote monitoring, such as medicine and fitness, where contact based monitoring is limiting and cumbersome. The blood volume pulse, defined as the pulsative flow of arterial blood, gives rise to periodic changes in the skin color which are then quantified to estimate a temporal signal. This temporal signal can be analysed using various methods to extract the representative cardiac signal...
February 9, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29426317/barriers-and-enablers-to-skin-to-skin-contact-at-birth-in-healthy-neonates-a-qualitative-study
#8
Amala James Alenchery, Joanne Thoppil, Carl Denis Britto, Jimena Villar de Onis, Lavina Fernandez, P N Suman Rao
BACKGROUND: Skin to skin contact (SSC) at birth is the standard of care for newborns without risk factors. However, implementation of SSC at birth has been far from optimal. A qualitative study was undertaken to determine the barriers, enablers and potential solutions to implementation of SSC at birth in healthy newborn infants in a level III neonatal-care facility in Bangalore, India. METHODS: Consultants and residents/postgraduates (PG) from the departments of Obstetrics (n = 19) and Pediatrics (n = 14) and nurses (n = 8) in the labor room (LR) participated in the study...
February 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29425655/could-essential-oils-enhance-biopolymers-performance-for-wound-healing-a-systematic-review
#9
REVIEW
Mercedes Pérez-Recalde, Ignacio E Ruiz Arias, Élida B Hermida
BACKGROUND: Millions of people in the world suffer from chronic wounds of different etiologies such as diabetic foot and leg ulcers, without solutions nowadays. Molecules obtained from plants offer an alternative to aid wound healing. Strong evidence about essential oils (EO) anti-inflammatory and antimicrobial properties is thoroughly described in literature and their chemical compositions are well characterized. More recently, EO effects in experimental wounds have begun to be analyzed...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29421582/ginseng-phytochemicals-as-therapeutics-in-oncology-recent-perspectives
#10
REVIEW
Fatima Majeed, Fozia Zahur Malik, Zaheer Ahmed, Asma Afreen, Muhammad Naveed Afzal, Nauman Khalid
During the last few decades, cancer has mushroomed as a major health issue; and almost all drugs used for its therapy are very toxic with lethal side effects. Complementary and alternative medicines gain popularity among health professionals in recent era owing to its preventive mechanism against side effect chemotherapeutic drugs. Efforts are focused by scientists to isolate compounds from medicinal plant that have chemotherapeutic attributes; and ability to neutralize the side effects of chemotherapy. Ginseng is an oriental medicinal recipe from Araliceae family and Panax species...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29411561/a-case-of-intraoperative-anaphylaxis-caused-by-bovine-derived-thrombin
#11
Hye Jung Park, Kyung Soo Suk, Jung Won Park
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29411317/nutraceuticals-a-review
#12
REVIEW
Skylar A Souyoul, Katharine P Saussy, Mary P Lupo
Skin aging is continuously influenced by various internal and external factors such as the biologic progression of cells, ultraviolet (UV) radiation, tobacco, nutritional deficiencies, and hormonal imbalances that lead to the degradation of skin cells. Through the degradation of skin cells, free radicals and inflammation weaken repair mechanisms and result in collagen and elastic fiber breakdown. The appearance of aging skin is highlighted by skin roughness, wrinkling, pigmentation change, telangiectasias, loss of elasticity, and decreased firmness, all of which are accelerated by these internal and external factors...
February 6, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29409933/signs-and-symptoms-in-1043-patients-with-complex-regional-pain-syndrome-crps
#13
Stephan Ott, Christian Maihöfner
Complex regional pain syndrome (CRPS) is a complex pain disorder that can emerge after limb trauma or a lesion in the peripheral nervous system. Typical features include continuing pain, sensory, vasomotor, sudomotor, motor and trophic changes as well as edema. These signs provide the basis of CRPS diagnosis. A detailed description of the signs, symptoms and medical history of CRPS could potentially facilitate an earlier and more accurate diagnosis. The aim of this study is to provide such a description, based on epidemiological measures, clinical presentation and a thorough description of pain sensations...
February 1, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29403054/quantitative-self-assembly-prediction-yields-targeted-nanomedicines
#14
Yosi Shamay, Janki Shah, Mehtap Işık, Aviram Mizrachi, Josef Leibold, Darjus F Tschaharganeh, Daniel Roxbury, Januka Budhathoki-Uprety, Karla Nawaly, James L Sugarman, Emily Baut, Michelle R Neiman, Megan Dacek, Kripa S Ganesh, Darren C Johnson, Ramya Sridharan, Karen L Chu, Vinagolu K Rajasekhar, Scott W Lowe, John D Chodera, Daniel A Heller
Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe herein a targeted drug delivery system that is accurately and quantitatively predicted to self-assemble into nanoparticles based on the molecular structures of precursor molecules, which are the drugs themselves. The drugs assemble with the aid of sulfated indocyanines into particles with ultrahigh drug loadings of up to 90%...
February 5, 2018: Nature Materials
https://www.readbyqxmd.com/read/29396641/-information-services-for-melanoma-patients-and-awareness-among-those-affected
#15
J Brütting, M Bergmann, C Weber, C Berking, W Tilgen, D Schadendorf, F Meier
BACKGROUND: Besides medical consultations, various sources of information and support are available for melanoma patients (MP) in Germany from commercial and non-commercial providers; however, little is known about how they are perceived and accepted by MPs. MATERIAL AND METHODS: Between July and October 2016 a total of 529 melanoma patients were surveyed at 27 accredited German skin cancer centers by means of a standardized questionnaire. Their awareness and satisfaction with 12 given sources of information and counseling services (print, online and by telephone) were surveyed...
February 2, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29395228/defining-the-medial-lateral-axis-of-the-femur-medical-imaging-conventional-and-functional-calibration-methods-lead-to-differences-in-hip-rotation-kinematics-for-children-with-torsional-deformities
#16
Elyse Passmore, H Kerr Graham, Morgan Sangeux
Hip rotation during gait is a major indicator for femoral derotation osteotomy. However, repeatability of hip rotation is poor because of discrepancies in determining the medial-lateral axis of the femur. Combining 3D gait analysis with medical imaging allows in vivo evaluation of current clinical methods. We used the condylar axis, identified from low dose biplanar radiographs (EOS imaging Inc), as our reference to evaluate conventional, functional calibration and freehand 3D ultrasound methods to define the medial-lateral axis in children with lower-limb torsional deformities...
January 29, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29391707/oral-candidiasis-a-retrospective-study-of-276-brazilian-patients
#17
Henrique Cortes Meira, Bruna Mascarenhas De Oliveira, Igor Figueiredo Pereira, Marcelo Drumond Naves, Ricardo Alves Mesquita, Vagner Rodrigues Santos
Background: Although oral candidiasis (OC) is a very common fungal infection of oral cavity, clinical features of affected patients and their demographic profile are not well documented. Objective: The objective of the study was to assess the demographic profile of patients diagnosed with OC and its clinical features in an import Brazilian center of oral and maxillofacial pathology. Materials and Methods: A retrospective study consisted of 276 patients diagnosed with OC by cytopathology Periodic Acid-Schiff (PAS) staining, during the period of 20 years...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29391000/computational-investigations-of-physicochemical-pharmacokinetic-toxicological-properties-and-molecular-docking-of-betulinic-acid-a-constituent-of-corypha-taliera-roxb-with-phospholipase-a2-pla2
#18
Mohammad Firoz Khan, Nusrat Nahar, Ridwan Bin Rashid, Akhtaruzzaman Chowdhury, Mohammad A Rashid
BACKGROUND: Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is performed to evaluate (a) physicochemical properties such as acid dissociation constant (pKa), distribution coefficient (logD), partition coefficient (logP), aqueous solubility (logS), solvation free energy, dipole moment, polarizability, hyperpolarizability and different reactivity descriptors, (b) pharmacokinetic properties like human intestinal absorption (HIA), cellular permeability, skin permeability (PSkin), plasma protein binding (PPB), penetration of the blood brain barrier (BBB), (c) toxicological properties including mutagenicity, carcinogenicity, risk of inhibition of hERG gene and (d) molecular mechanism of anti-inflammatory action which will aid the development of analytical method and the synthesis of BA derivatives...
February 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29386416/childhood-cerebral-x-linked-adrenoleukodystrophy-with-atypical-neuroimaging-abnormalities-and-a-novel-mutation
#19
M Muranjan, S Karande, S Sankhe, S Eichler
Childhood cerebral X-linked adrenoleukodystrophy (XALD) typically manifests with symptoms of adrenocortical insufficiency and a variety of neurocognitive and behavioral abnormalities. A major diagnostic clue is the characteristic neuroinflammatory parieto-occipital white matter lesions on magnetic resonance imaging. This study reports a 5-year 10-month old boy presenting with generalized skin hyperpigmentation since 3 years of age. Over the past 9 months, he had developed right-sided hemiparesis and speech and behavioral abnormalities, which had progressed over 5 months to bilateral hemiparesis...
January 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29380667/skin-diseases-in-the-era-of-highly-active-antiretroviral-therapy-a-retrospective-study-of-534-patients
#20
Jennifer Tan, Ana Pina, João Borges-Costa
BACKGROUND: With the increasing number of HIV-infected patients receiving highly active antiretroviral therapy (HAART), the shift in their dermatologic profile becomes less characteristic of AIDS-defining illnesses. METHODS: Retrospective review of mucocutaneous pathology among patients seen at HIV-Dermatology Clinic from January 2009 to December 2013. RESULTS: Among 534 patients, there were 68.4% males and 31.6% females, with 8.7-year average duration of infection; 82...
January 2018: Journal of the International Association of Providers of AIDS Care
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