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https://www.readbyqxmd.com/read/27909641/a-case-series-of-complex-recalcitrant-wounds-treated-with-epidermal-grafts-harvested-from-an-automated-device
#1
Stephen S Cai, Arvind U Gowda, Karan Chopra, Rachel Waldman, Ronald P Silverman, Yvonne M Rasko
INTRODUCTION: Epidermal grafting has several advantages over full-thickness or split-thickness grafts in the treatment of complex non-healing wounds. These include the low risk of donor site complications, minimal patient discomfort, and abstention from the operating room. Traditionally, the lack of reliable epidermal harvesting techniques has limited its clinical utilization. The development of an automated suction blister epidermal graft (SBEG) harvesting device may facilitate clinical utilization of this technique...
October 30, 2016: Curēus
https://www.readbyqxmd.com/read/27878297/hydroxyproline-containing-collagen-peptide-derived-from-the-skin-of-the-alaska-pollack-inhibits-hiv-1-infection
#2
In Seung Jang, Sun Joo Park
The human immunodeficiency virus (HIV) is a lentivirus that results in acquired immunodeficiency syndrome (AIDS). HIV treatment involving chemical therapeutic agents has improved the quality of life of HIV/AIDS patients. The present study demonstrates that a hydroxyproline-containing marine collagen peptide (APHCP) derived from Alaska pollack inhibits HIV‑1 infection in the MT-4 human T cell‑line. APHCP inhibited HIV-1IIIB-induced cell lysis, syncytia formation, reverse transcriptase activity and viral p24 production at non‑cytotoxic concentrations; however, APHCP did not inhibit HIV‑2ROD infection in MT‑4 cells...
November 16, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27843352/profile-of-once-daily-darunavir-cobicistat-fixed-dose-combination-for-the-treatment-of-hiv-aids
#3
REVIEW
Jordi Navarro, Adrian Curran
Efficacy is the main objective of antiretroviral treatment and adherence is one of the cornerstones to achieve it. For this reason, treatment simplification is of key importance with regard to antiretroviral regimens. Rezolsta® (darunavir/cobicistat) is the first fixed-dose combination containing a protease inhibitor approved for HIV treatment. This coformulation includes darunavir, a protease inhibitor that has shown its efficacy and safety in naïve and treatment-experienced patients, and cobicistat, the new pharmacokinetic enhancer that is expected to replace ritonavir...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27818966/sexually-transmitted-infections-among-hospitalized-patients-with-human-immunodeficiency-virus-infection-and-acquired-immune-deficiency-syndrome-hiv-aids-in-zahedan-southeastern-iran
#4
Seyed Mohammad Hashemi-Shahri, Batool Sharifi-Mood, Hamid-Reza Kouhpayeh, Javad Moazen, Mohsen Farrokhian, Masoud Salehi
BACKGROUND: Studies show that nearly 40 million people are living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) around the world and since the beginning of the epidemic, about 35 million have died from AIDS. Heterosexual intercourse is the most common route for transmission of HIV infection (85%). People with a sexually transmitted infection (STI), such as syphilis, genital herpes, chancroid, or bacterial vaginosis, are more likely to obtain HIV infection during sex...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27815548/de%C3%A2-novo-hiv-infection-diagnoses-in-a-department-of-dermatology-and-venereology-in-lisbon-portugal
#5
Pedro Mendes-Bastos, Ana Brasileiro, Eugénia Matos-Pires, Isaura Rodrigues, Cristina Marques, Vasco Coelho-Macias, Cândida Fernandes
BACKGROUND: Portugal has the highest prevalence rate of HIV infection in Western Europe. The proportion of patients with a late diagnosis, carried out in full-blown AIDS stage, remains high. Skin and mucous membrane manifestations are not rare in these patients. OBJECTIVE: A demographic, clinical, and laboratorial characterization of patients with de novo HIV infection diagnosis made in the Department of Dermatology and Venereology of a central hospital in Lisbon, Portugal...
November 4, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27781103/ageing-and-menopause-considerations-for-women-with-hiv-in-the-uk
#6
EDITORIAL
L Sherr, A Molloy, A Macedo, N Croome, M A Johnson
OBJECTIVES: Treatment rollout has dramatically improved life expectancy for people with HIV and AIDS. Women represent a substantial proportion of patients in the UK (approximately one-third of patients in care are female according to the HIV Annual Report 2014). This study examines psychosocial and biomedical issues for women diagnosed with HIV in the UK, comparing those above and below 45 years of age to examine menopause and ageing issues. METHODS: Consecutive clinic attenders in a large outpatient London HIV clinic were invited to participate in the study...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27760126/self-reported-side-effects-and-adherence-to-antiretroviral-therapy-in-hiv-infected-pregnant-women-under-option-b-a-prospective-study
#7
Tamsin Phillips, Annibale Cois, Robert H Remien, Claude A Mellins, James A McIntyre, Greg Petro, Elaine J Abrams, Landon Myer
BACKGROUND: Antiretroviral therapy (ART) regimens containing efavirenz (EFV) are recommended as part of universal ART for pregnant and breastfeeding women. EFV may have appreciable side effects (SE), and ART adherence in pregnancy is a major concern, but little is known about ART SE and associations with adherence in pregnancy. METHODS: We investigated the distribution of patient-reported SE (based on Division of AIDS categories) and the association of SE with missed ART doses in a cohort of 517 women starting EFV+3TC/FTC+TDF during pregnancy...
2016: PloS One
https://www.readbyqxmd.com/read/27749931/gastrointestinal-symptoms-in-hiv-infected-patients-female-sex-and-smoking-as-risk-factors-in-an-outpatient-cohort-in-brazil
#8
Annelisa Silva E Alves de Carvalho Santos, Erika Aparecida Silveira, Marianne de Oliveira Falco
This study aimed to estimate the incidence of gastrointestinal symptoms (GIS) and associated factors in an outpatient cohort of people living with HIV/AIDS (PLWHA) followed between October 2009 and July 2011. We evaluated nausea and/or vomiting, dyspepsia, heartburn, diarrhea, constipation, and flatulence. The outcome variable was the presence of three or more GIS. Sociodemographic (sex, skin color, age, income, years of schooling), lifestyle (smoking status, alcohol consumption, physical activity level), clinical (antiretroviral therapy, time of HIV infection, CD4 lymphocyte count, viral load), and anthropometric (nutritional status and waist circumference) variables were investigated...
2016: PloS One
https://www.readbyqxmd.com/read/27681148/adverse-drug-reactions-associated-with-antiretroviral-therapy-in-south-africa
#9
Sumeshni Birbal, Mukesh Dheda, Elizabeth Ojewole, Frasia Oosthuizen
South Africa has one of the highest prevalences of HIV and AIDS in the world. HIV/AIDS patients face countless challenges, one of which is the risk of adverse drug reactions (ADRs). This study aimed to describe the ADRs reported in South Africa with reference to the type of ADRs, antiretrovirals (ARVs) implicated, seriousness of the ADRs and patient demographics associated with specific ADRs. A retrospective quantitative study was carried out using ADR reports submitted to the National Department of Health (NDoH) from 1 January 2010 to 31 December 2014...
September 2016: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/27651732/hiv-1-evolutionary-patterns-associated-with-metastatic-kaposi-s-sarcoma-during-aids
#10
Susanna L Lamers, Rebecca Rose, David J Nolan, Gary B Fogel, Andrew E Barbier, Marco Salemi, Michael S McGrath
Kaposi's sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer. KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected. In this study we tested if HIV evolutionary patterns distinguish KS tumor relatedness and progression. Multisite autopsies from participants who died from HIV-AIDS with KS prior to the availability of antiretroviral therapy were identified at the AIDS and Cancer Specimen Resource (ACSR)...
2016: Sarcoma
https://www.readbyqxmd.com/read/27566775/immune-reconstitution-inflammatory-syndrome-associated-with-secondary-syphilis
#11
Simona Frunza-Stefan, Gyanendra Acharya, Viktoryia Kazlouskaya, Paunel Vukasinov, Yushan Chiou, Zeyar Thet
Immune reconstitution inflammatory syndrome (IRIS) is a condition associated with paradoxical worsening and/or new onset of an opportunistic infection in HIV patients following the initiation of anti-retroviral therapy or switching to more potent antiretroviral therapy (ART) regimen. Although IRIS associated with many opportunistic infections (OIs) has been well reported, syphilis has very rarely been mentioned in this regard. A 52-year-old male, diagnosed with AIDS six weeks ago, presented with the disseminated non-pruritic painless skin rash...
August 26, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27542868/vaccination-status-of-people-living-with-hiv-aids-in-outpatient-care-in-fortaleza-cear%C3%A3-brazil
#12
Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão, Camila Martins de Medeiros, Ryvanne Paulino Rocha, Maria Amanda Correia Lima, Francisco Vagnaldo Fechine
Antiretroviral therapy has increased the survival of patients with HIV/AIDS, thus necessitating health promotion practice with immunization. Vaccines are critical components for protecting people living with HIV/AIDS (PLWHA). The purpose of study was to analyze the vaccination status of PLWHA in outpatient care in Fortaleza, Ceará, Brazil. Cross-sectional study performed from June 2014 to June 2015. The screening was done with patients in antiretroviral therapy, 420 patients underwent screening, but only 99 met the inclusion criteria...
September 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27408991/dramatic-treatment-response-of-cutaneous-plasmablastic-lymphoma-in-an-hiv-patient-a-case-report
#13
S M Nazmus Sakib, Michael Sadler
Plasmablastic lymphoma is a variant of diffuse large B-cell lymphoma, characterized by rapid progression and is associated with a poor outcome. We report a 35-year-old male with poorly controlled HIV infection and AIDS who presented with skin lesions and swelling throughout the body. Computed tomography (CT) revealed innumerable enhancing soft tissue masses within the subcutaneous soft tissues and lymphadenopathy. Plasmablastic lymphoma was diagnosed, patient was treated with chemotherapy, and post treatment CT demonstrated complete resolution...
June 17, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27313920/challenges-in-treating-secondary-syphilis-osteitis-in-an-immunocompromised-patient-with-a-penicillin-allergy-case-report-and-review-of-the-literature
#14
Robert Ali, Julio Perez-Downes, Firas Baidoun, Bashar Al Turk, Carmen Isache, Girish Mohan, Charles Perniciaro
Syphilis is a sexually transmitted infection that remains fairly commonplace. The introduction of penicillin aided in curbing the incidence of disease; however, with the advent of the human immunodeficiency virus (HIV), syphilis is now on a resurgence with sometimes curious presentations. We present a case of a 36-year-old Caucasian gentleman with untreated HIV who complained of a skin eruption and joint pains for 6 weeks, prompting the diagnosis of secondary syphilis osteitis. Skin lesions were reminiscent of "malignant" syphilis...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27295809/prevalence-of-skin-diseases-in-children-with-human-immunodeficiency-syndrome-infection-in-paediatric-hiv-clinic-of-a-tertiary-hospital-in-nigeria
#15
B O Osinaike, E O Temiye, O Odusote, A O Akinsulie, E Iroha
BACKGROUND: HIV infection/AIDS being a multi-systemic disease affects the skin at various stages in course of the illness. A knowledge of the common skin diseases associated with HIV infection can lead to early detection, appropriate staging and commencement of appropriate care in the infected patients. OBJECTIVE: The study was to document the prevalence and pattern of skin diseases in children with HIV infection seen at the Paediatric department of a tertiary centre in Nigeria...
July 2015: Nigerian Quarterly Journal of Hospital Medicine
https://www.readbyqxmd.com/read/27243774/three-months-of-weekly-rifapentine-and-isoniazid-for-treatment-of-mycobacterium-tuberculosis-infection-in-hiv-coinfected-persons
#16
Timothy R Sterling, Nigel A Scott, Jose M Miro, Guilherme Calvet, Alberto La Rosa, Rosa Infante, Michael P Chen, Debra A Benator, Fred Gordin, Constance A Benson, Richard E Chaisson, M Elsa Villarino
OBJECTIVE: Compare the effectiveness, tolerability, and safety of 3 months of weekly rifapentine and isoniazid under direct observation (3HP) versus 9 months of daily isoniazid (9H) in HIV-infected persons. DESIGN: Prospective, randomized, and open-label noninferiority trial. SETTING: The United States , Brazil, Spain, Peru, Canada, and Hong Kong. PARTICIPANTS: HIV-infected persons who were tuberculin skin test positive or close contacts of tuberculosis cases...
June 19, 2016: AIDS
https://www.readbyqxmd.com/read/27242923/treatment-of-dermatological-conditions-associated-with-hiv-aids-the-scarcity-of-guidance-on-a-global-scale
#17
REVIEW
Suchismita Paul, Rachel Evans, Toby Maurer, Lulu M Muhe, Esther E Freeman
Background. Skin diseases associated with Human Immunodeficiency Virus (HIV) infection are associated with significant morbidity and mortality. In resource-limited settings, nondermatologists and lay health care providers on the front line of HIV care provide much of the treatment for these conditions. Objective. To evaluate guidelines for treatment of HIV-related skin conditions and assess their accessibility, comprehensiveness, and quality of evidence employed. Methods. A review was undertaken of all national and society guidelines which included treatment information on the ten highest burden HIV-related skin conditions...
2016: AIDS Research and Treatment
https://www.readbyqxmd.com/read/27227446/histoplasma-capsulatum-sinusitis-possible-way-of-revelation-to-the-disseminated-form-of-histoplasmosis-in-hiv-patients-case-report-and-literature-review
#18
R Elansari, R Abada, S Rouadi, M Roubal, M Mahtar
INTRODUCTION: Histoplasma capsulatum is rarely found in nose and sinuses in immunocompetent and even in immunosupressed patients. A literature review revealed rare cases of H. capsulatum sinusitis and the case we describe in this paper is the first case of H. capsulatum sinusitis in Morocco. The purpose of our work is to present a rare case of H. capsulatum sinusitis and a literature review. CASE REPORT: A male patient, at his 39 presented to the emergency with suffered from nasal congestion and yellow postnasal rhinorrhea, occasional headaches and epistaxis for over than two months...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27190420/erythema-elevatum-diutinum-in-acquired-immune-deficiency-syndrome-can-it-be-an-immune-reconstitution-inflammatory-syndrome
#19
Sheethal K Jose, Yogesh S Marfatia
A 47-year-old male with acquired immune deficiency syndrome (AIDS) presented with multiple hyperpigmented papules and nodules on both ankles, dorsum of bilateral feet and soles. It was associated with mild itching and pain. The patient was diagnosed with human immunodeficiency virus (HIV) in 2007. First-line antiretroviral therapy (ART) was started in 2009 to which he responded initially. He was shifted to second-line ART 11 months ago in March 2015 due to treatment failure as suggested by CD4 count of 50 cells/mm(3)...
January 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27177037/expression-pattern-of-the-cxcl12-cxcr4-cxcr7-trio-in-kaposi-s-sarcoma-skin-lesions
#20
A Desnoyer, N Dupin, L Assoumou, A Carlotti, F Gaudin, C Deback, G Peytavin, A G Marcelin, F Boué, K Balabanian, V Pourcher-Martinez
BACKGROUND: Recent studies have independently implicated the chemokine CXCL12 and its receptors, CXCR4 and CXCR7, in KS pathophysiology. OBJECTIVES: We investigated whether the CXCL12/CXCR4-CXCR7 protein trio could constitute KS biomarkers. METHODS: Endothelial and spindle cells positive for CXCL12/CXCR4-CXCR7, HHV-8 latency-associated nuclear antigen (LANA), Ki67 antigen (proliferation), and vascular endothelial growth factor (VEGF) were quantitated in skin lesions from patients with AIDS-KS, with classic-KS, and with angiomas, using immunohistochemistry and quantitative image analysis (16, 21 and 20 skin lesions respectively)...
May 13, 2016: British Journal of Dermatology
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