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https://www.readbyqxmd.com/read/29456824/a-brief-review-on-features-of-falciparum-malaria-during-pregnancy
#1
Alexandre Manirakiza, Eugène Serdouma, Richard Norbert Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock Mbetid Degana, Gislain Géraud Banthas Bata, Jean Methode Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou
Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum- infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa...
December 31, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/29454844/the-epidemiology-of-febrile-illness-in-sub-saharan-africa-implications-for-diagnosis-and-management
#2
REVIEW
Michael J Maze, Quique Bassat, Nicholas A Feasey, Inácio Mandomando, Patrick Musicha, John A Crump
BACKGROUND: Fever is among the most common symptoms of people living in Africa, and clinicians are challenged by the similar clinical features of a wide spectrum of potential aetiologies. AIM: To summarise recent studies of fever aetiology in sub-Saharan Africa focusing on causes other than malaria. SOURCES: A narrative literature review by searching the MEDLINE database, and recent conference abstracts. CONTENT: Studies of multiple potential causes of fever are scarce, and for many participants the infecting organism remains unidentified, or multiple co-infecting microorganisms are identified, and establishing causation is challenging...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29454383/multidimensional-needs-of-patients-living-and-dying-with-heart-failure-in-kenya-a-serial-interview-study
#3
Kellen N Kimani, Scott A Murray, Liz Grant
BACKGROUND: Heart failure is an emerging challenge for Sub Saharan Africa. However, research on patients' needs and experiences of care is scarce with little evidence available to support and develop services. We aimed to explore the experiences of patients living and dying with heart failure in Kenya. METHODS: We purposively recruited 18 patients admitted with advanced heart failure at a rural district hospital in Kenya. We conducted serial in depth interviews with patients at 0, 3 and 6 months after recruitment, and conducted bereavement interviews with carers...
February 17, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29454211/seasonality-water-use-and-community-management-of-water-systems-in-rural-settings-qualitative-evidence-from-ghana-kenya-and-zambia
#4
Emma Kelly, Katherine F Shields, Ryan Cronk, Kristen Lee, Nikki Behnke, Tori Klug, Jamie Bartram
The sustainability of rural, community-managed water systems in sub-Saharan Africa depends in part on the ability of local water committees to repair breakdowns and carry out the operation and maintenance (O&M) of the system. Much of sub-Saharan Africa has two distinct seasons that affect the availability of water sources and how people use water. Little is known about how seasonality affects water system management. This qualitative study is based on 320 interviews and focus group discussions and examines the effects of season on community water use and management in Ghana, Kenya and Zambia...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453854/cost-effective-innovations-in-low-resource-settings
#5
Olivia H Chang, Jeffrey P Wilkinson
As health technologies are slowly adapted in low resource settings, the support modalities, equipment and supplies that allow these advances to be implemented are often not fully considered. It is not uncommon to install a new computed tomography scan machine in a hospital in sub-Saharan Africa only to suffer extensive downtime from unreliable electricity supply or unavailability of contrast agents (Essential Health Technologies WHO 2011). Countless expensive high-tech devices sit idle in low resource settings for lack of proper disposables and properly trained health care professionals...
February 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29452587/timing-of-abortion-among-adolescent-and-young-women-presenting-for-post-abortion-care-in-kenya-a-cross-sectional-analysis-of-nationally-representative-data
#6
Boniface A Ushie, Chimaraoke O Izugbara, Michael M Mutua, Caroline W Kabiru
BACKGROUND: Complications of unsafe abortion are a leading cause of maternal mortality in sub-Saharan Africa. Adolescents and young women are disproportionately represented among those at risk of these complications. Currently, we know little about the factors associated with young women's timing of abortion. This study examined the timing of abortion as well as factors influencing it among adolescents and young women aged 12-24 years who sought post-abortion care (PAC) in health facilities in Kenya...
February 17, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29452365/indigenous-medicine-and-biomedical-health-care-in-fragile-settings-insights-from-burundi
#7
Jean-Benoît Falisse, Serena Masino, Raymond Ngenzebuhoro
This study contributes to the health policy debate on medical systems integration by describing and analysing the interactions between health-care users, indigenous healers, and the biomedical public health system, in the so far rarely documented case of post-conflict Burundi. We adopt a mixed-methods approach combining (1) data from an existing survey on access to health-care, with 6,690 individuals, and (2) original interviews and focus groups conducted in 2014 with 121 respondents, including indigenous healers, biomedical staff, and health-care users...
February 14, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29452047/lessons-learned-from-ebola-vaccine-r-d-during-a-public-health-emergency
#8
Marie-Paule Kieny
In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29449781/whole-genome-sequencing-of-multidrug-resistant-salmonella-enterica-serovar-typhimurium-isolated-from-humans-and-poultry-in-burkina-faso
#9
Assèta Kagambèga, Taru Lienemann, Jonathan G Frye, Nicolas Barro, Kaisa Haukka
Background: Multidrug-resistant Salmonella is an important cause of morbidity and mortality in developing countries. The aim of this study was to characterize and compare multidrug-resistant Salmonella enterica serovar Typhimurium isolates from patients and poultry feces. Methods: Salmonella strains were isolated from poultry and patients using standard bacteriological methods described in previous studies. The strains were serotype according to Kaufmann-White scheme and tested for antibiotic susceptibility to 12 different antimicrobial agents using the disk diffusion method...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29449638/protection-from-experimental-cerebral-malaria-with-a-single-intravenous-or-subcutaneous-whole-parasite-immunization
#10
Kirsten Heiss, Marion Irmgard Maier, Angelika Hoffmann, Roland Frank, Martin Bendszus, Ann-Kristin Mueller, Johannes Pfeil
Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448884/ameliorating-the-in-vivo-antimalarial-efficacy-of-artemether-using-nanostructured-lipid-carriers
#11
Vanka Ravisankar, Gowthamarajan Kuppusamy, Praveen Kumar Simhadri, Uday Krishna Baruah, Veera Venkata Satyanarayana Reddy Karri, Vimal Pandey, Phanithi Prakash Babu
Cerebral malaria (CM) is a fatal neurological complication of Plasmodium falciparum infection that affects children (below five years old) in sub-Saharan Africa and adults in South-East Asia each year having the fatality rate of 10-25%. The survivors of CM also have high risk of long term neurological or cognitive deficits. The objective of the present investigation was to develop optimized nanostructured lipid carriers (NLCs) of artemether (ARM) for enhanced anti-malarial efficacy of ARM.NLCs of ARM were prepared by a combination of high speed homogenization (HSH) and probe sonication techniques...
February 16, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29447356/barriers-to-the-availability-and-accessibility-of-controlled-medicines-for-chronic-pain-in-africa
#12
Elmang Nchako, Scottie Bussell, Carlos Nesbeth, Chisom Odoh
Africans endure a high burden of pain and suffering from HIV/AIDS and cancer, yet receive a meager amount of the world's pain medication. This tragedy occurs needlessly, given that inexpensive, effective and easily administered interventions are available. WHO has a 'three-step analgesic ladder' framework for managing cancer pain. This widely adopted clinical practice guideline is an integral part of palliative care programs and has also been applied to non-cancer pain. However, untreated pain is a major public health problem due to the discordance between scientific evidence and public policy...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29447273/molecular-epidemiology-and-drug-sensitivity-pattern-of-mycobacterium-tuberculosis-strains-isolated-from-pulmonary-tuberculosis-patients-in-and-around-ambo-town-central-ethiopia
#13
Melaku Tilahun, Gobena Ameni, Kassu Desta, Aboma Zewude, Lawrence Yamuah, Markos Abebe, Abraham Aseffa
INTRODUCTION: Tuberculosis (TB) is caused by M. tuberculosis complex and remains a major global public health problem. The epidemic remains a threat to sub-Saharan Africa, including Ethiopia, with further emergence of drug resistant TB. We investigated the drug sensitivity pattern and molecular epidemiology of mycobacterial strains isolated from pulmonary TB patients in and around Ambo town in Oromia Region, Central Ethiopia. METHODS: A cross-sectional study was conducted involving 105 consecutive new smear positive pulmonary TB patients diagnosed at Ambo Hospital and surrounding Health Centers between May 2014 and March 2015 upon informed consent...
2018: PloS One
https://www.readbyqxmd.com/read/29447257/access-to-health-insurance-coverage-among-sub-saharan-african-migrants-living-in-france-results-of-the-anrs-parcours-study
#14
Nicolas Vignier, Annabel Desgrées du Loû, Julie Pannetier, Andrainolo Ravalihasy, Anne Gosselin, France Lert, Nathalie Lydié, Olivier Bouchaud, Rosemary Dray Spira
BACKGROUND: Migrants' access to care depends on their health insurance coverage in the host country. We aimed to evaluate in France the dynamic and the determinants of health insurance coverage acquisition among sub-Saharan migrants. METHODS: In the PARCOURS life-event retrospective survey conducted in 2012-2013 in health-care facilities in the Paris region, data on health insurance coverage (HIC) each year since arrival in France has been collected among three groups of sub-Saharan migrants recruited in primary care centres (N = 763), centres for HIV care (N = 923) and for chronic hepatitis B care (N = 778)...
2018: PloS One
https://www.readbyqxmd.com/read/29447231/preparedness-of-lower-level-health-facilities-and-the-associated-factors-for-the-outpatient-primary-care-of-hypertension-evidence-from-tanzanian-national-survey
#15
Deogratius Bintabara, Bonaventura C T Mpondo
INTRODUCTION: Sub-Saharan Africa is experiencing a rapid rise in the burden of non-communicable diseases in both urban and rural areas. Data on health system preparedness to manage hypertension and other non-communicable diseases remains scarce. This study aimed to assess the preparedness of lower-level health facilities for outpatient primary care of hypertension in Tanzania. METHODS: This study used data from the 2014-2015 Tanzania Service Provision Assessment survey...
2018: PloS One
https://www.readbyqxmd.com/read/29446825/phytomedicines-medicines-derived-from-plants-for-sickle-cell-disease
#16
REVIEW
Oluseyi Oniyangi, Damian H Cohall
BACKGROUND: Sickle cell disease, a common recessively inherited haemoglobin disorder, affects people from sub-Saharan Africa, the Middle East, Mediterranean basin, Indian subcontinent, Caribbean and South America. It is associated with complications and a reduced life expectancy. Phytomedicines (medicine derived from plants in their original state) encompass many of the plant remedies from traditional healers which the populations most affected would encounter. Laboratory research and limited clinical trials have suggested positive effects of phytomedicines both in vivo and in vitro...
February 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29446436/the-wits-atlas-a-black-southern-african-dental-atlas-for-permanent-tooth-formation-and-emergence
#17
Temitope A Esan, Lynne A Schepartz
Current dental maturity charts, such as the widely applied London atlas, do not take into consideration advanced tooth emergence and formation patterns observed in children of African ancestry. The result is inaccurate age estimation in Southern Africa, a region where there is great forensic and anthropological need for reliable age estimation. OBJECTIVES: To develop a population-specific atlas of permanent tooth emergence and formation for age estimation of Black Southern Africans. MATERIALS AND METHODS: Using data from a cross-sectional study of 642 school children aged 5-20 years, panoramic radiographs taken during routine dental examination in a mobile treatment van were analyzed using the Demirjian method of eight (A-H) tooth formation stages...
February 15, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29446219/hypertension-in-a-resource-limited-setting-is-it-associated-with-end-organ-damage-in-older-adults-in-rural-tanzania
#18
Harry W I Putnam, Rebecca Jones, Jane Rogathi, William K Gray, Bernadetha Swai, Matthew Dewhurst, Felicity Dewhurst, Richard W Walker
Few data from sub-Saharan Africa exist on the effects of hypertension on the organs of the human body. We aimed to establish the prevalence of hypertensive end organ damage (EOD) in an elderly cohort of Tanzanians. The population aged 70 years and over of 2 villages in northern Tanzania (n = 246), had blood pressure (BP) data available from 2010 and 2013, and underwent in-depth follow-up for markers of hypertensive EOD in 2016. Assessment included ankle-brachial pressure index, lying-standing BP, electrocardiogram, and mid-stream urine dip...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29444670/breast-cancer-in-ethiopia-evidence-for-geographic-difference-in-the-distribution-of-molecular-subtypes-in-africa
#19
Endale Hadgu, Daniel Seifu, Wondemagegnhu Tigneh, Yonas Bokretsion, Abebe Bekele, Markos Abebe, Thomas Sollie, Sofia D Merajver, Christina Karlsson, Mats G Karlsson
BACKGROUND: Breast cancer is a heterogeneous disease with several morphological and molecular subtypes. Widely accepted molecular classification system uses assessment of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker Ki67. Few studies have been conducted on the incidence and molecular types of breast cancer in Sub-Saharan Africa. Previous studies mainly from Western and Central Africa, showed breast cancer to occur at younger ages and to present with aggressive features, such as high-grade, advanced stage and triple-negative phenotype (negative for ER, PR and HER2)...
February 14, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29443053/neuroimaging-field-methods-using-functional-near-infrared-spectroscopy-nirs-neuroimaging-to-study-global-child-development-rural-sub-saharan-africa
#20
Kaja K Jasińska, Sosthène Guei
Portable neuroimaging approaches provide new advances to the study of brain function and brain development with previously inaccessible populations and in remote locations. This paper shows the development of field functional Near Infrared Spectroscopy (fNIRS) imaging to the study of child language, reading, and cognitive development in a rural village setting of Côte d'Ivoire. Innovation in methods and the development of culturally appropriate neuroimaging protocols allow a first-time look into the brain's development and children's learning outcomes in understudied environments...
February 2, 2018: Journal of Visualized Experiments: JoVE
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