keyword
MENU ▼
Read by QxMD icon Read
search

fragile states

keyword
https://www.readbyqxmd.com/read/28944990/children-concurrently-wasted-and-stunted-a-meta-analysis-of-prevalence-data-of-children-6-59%C3%A2-months-from-84-countries
#1
Tanya Khara, Martha Mwangome, Moses Ngari, Carmel Dolan
Children can be stunted and wasted at the same time. Having both deficits greatly elevates risk of mortality. The analysis aimed to estimate the prevalence and burden of children aged 6-59 months concurrently wasted and stunted. Data from demographic and health survey and Multi-indicator Cluster Surveys datasets from 84 countries were analysed. Overall prevalence for being wasted, stunted, concurrently wasted, and stunted among children 6 to 59 months was calculated. A pooled prevalence of concurrence was estimated and reported by gender, age, United Nations regions, and contextual categories...
September 25, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28943283/step-inhibition-reverses-behavioral-electrophysiologic-and-synaptic-abnormalities-in-fmr1-ko-mice
#2
Manavi Chatterjee, Pradeep K Kurup, Camilla J Lundbye, Anna Karina Hugger Toft, Jeemin Kwon, Jessie Benedict, Marija Kamceva, Tue G Banke, Paul J Lombroso
Fragile X syndrome (FXS) is the leading cause of inherited intellectual disability, with additional symptoms including attention deficit and hyperactivity, anxiety, impulsivity, and repetitive movements or actions. The majority of FXS cases are attributed to a CGG expansion that leads to transcriptional silencing and diminished expression of fragile X mental retardation protein (FMRP). FMRP, an RNA binding protein, regulates the synthesis of dendritically-translated mRNAs by stalling ribosomal translation. Loss of FMRP leads to increased translation of some of these mRNAs, including the CNS-specific tyrosine phosphatase STEP (STriatal-Enriched protein tyrosine Phosphatase)...
September 21, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28931866/ion-channel-aligned-gas-blocking-membrane-for-lithium-air-batteries
#3
Wonsung Choi, Mokwon Kim, Jung Ock Park, Joon-Hee Kim, Kyunghwan Choi, Yong Su Kim, Tae Young Kim, Ken Ogata, Dongmin Im, Seok-Gwang Doo, Yunil Hwang
Lithium-metal-based batteries, owing to the extremely high specific energy, have been attracting intense interests as post-Li-ion batteries. However, their main drawback is that consumption/de-activation of lithium metal can be accelerated when O2 or S used in the cathode crosses over to the metal, reducing the lifetime of the batteries. In use of ceramic solid state electrolyte (SSE) separator, despite the capability of gas blocking, thick and heavy plates (~0.3 mm) are necessitated to compensate its mechanical fragility, which ruin the high specific energy of the batteries...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28863533/primary-%C3%AE-and-secondary-%C3%AE-relaxation-dynamics-of-meta-toluidine-in-the-liquid-state-investigated-by-broadband-dielectric-spectroscopy
#4
H Švajdlenková, A Ruff, P Lunkenheimer, A Loidl, J Bartoš
We report a broadband dielectric spectroscopic (BDS) study on the clustering fragile glass-former meta-toluidine (m-TOL) from 187 K up to 289 K over a wide frequency range of 10(-3)-10(9) Hz with focus on the primary α relaxation and the secondary β relaxation above the glass temperature Tg. The broadband dielectric spectra were fitted by using the Havriliak-Negami (HN) and Cole-Cole (CC) models. The β process disappearing at Tβ,disap = 1.12Tg exhibits non-Arrhenius dependence fitted by the Vogel-Fulcher-Tamman-Hesse equation with T0β(VFTH) in accord with the characteristic differential scanning calorimetry (DSC) limiting temperature of the glassy state...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28846483/palliative-care-needs-in-an-acute-internal-medicine-ward-in-mexico
#5
Tania Zertuche-Maldonado, Rodrigo Tellez-Villarreal, Antonio Pascual, Salvador B Valdovinos-Chavez, Abel Jesus Barragan-Berlanga, Maria Teresa Sanchez-Avila, Leonardo Bracho-Vela, Adria Tinoco-Aranda, Eduardo Bruera
BACKGROUND: Palliative care is an evolving but underdeveloped practice in Mexico. OBJECTIVE: The primary end point of this prospective observational study was to identify internal medicine inpatients fulfilling advanced criteria within a second-level hospital. Secondary end points were symptom burden, treatment, resource utilization, and one-year survival. DESIGN AND MEASUREMENTS: The 390-sample size calculation was based on previous studies where 15% of inpatients fulfilled palliative care needs...
August 28, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28840728/site-specific-fluorescence-depolarization-kinetics-distinguishes-the-amyloid-folds-responsible-for-distinct-yeast-prion-strains
#6
Dominic Narang, Hema M Swasthi, Sayanta Mahapatra, Samrat Mukhopadhyay
The prion determinant of a yeast prion protein, Sup35NM, assembles into β-rich amyloid fibrils that switch the nonprion [psi(-)] state to the prion [PSI(+)] state of yeast. Previous studies showed that two distinct forms of amyloids (Sc4 and Sc37), generated in vitro at two different temperatures (4 and 37 °C), recapitulate the strain phenomenon in Saccharomyces cerevisiae. Sc4 demonstrates a strong [PSI(+)] phenotype, whereas Sc37 shows a weak phenotype. To discern the residue-specific structural and dynamical attributes associated with the amyloids that display strain diversity, we took advantage of the nonoccurrence of tryptophan (Trp) in the NM-domain and created 18 single-Trp variants spanning the entire polypeptide length...
September 5, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28837506/coagulopathy-in-children-with-liver-disease
#7
Patricia Sachi Kawada, Aisha Bruce, Patti Massicotte, Mary Bauman, Jason Yap
It was thought that a high International Normalized Ratio (INR) predicted bleeding in patients with chronic liver disease (CLD) and patients were 'autoanticoagulated'. Contrary to this belief, while patients with CLD experienced bleeding, they also developed thromboses. In the last decade, the prevailing literature challenged the idea that an elevated INR increased bleeding risk. The global assays of coagulation such as: thromboelastography (TEG)/rotational thromboelastometry (ROTEM) and thrombin generation assays (TGA) provide additional insight into coagulation processes...
August 23, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28828426/kinetic-fragility-and-structure-of-lithium-borophosphate-glasses-analysed-by-1d-2d-nmr
#8
Laura Muñoz-Senovilla, Gregory Tricot, Francisco Muñoz
The macroscopic and high temperature properties of lithium borophosphate glasses were determined in this contribution. Our data, obtained on 50Li2O-xB2O3-(50-x)P2O5 glasses, confirm a continuous and linear increase of the glass transition temperature with the B/P substitution but show a two-domain evolution of the kinetic fragility with a steep decrease in the low B2O3 region (0 ≤ x ≤ 10) followed by a moderate increase for higher B2O3 contents. In order to understand this different behaviour, the glass structure was investigated in detail using 1D and 2D (11)B/(31)P correlation solid state nuclear magnetic resonance...
August 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28826631/multifarious-functions-of-the-fragile-x-mental-retardation-protein
#9
REVIEW
Jenna K Davis, Kendal Broadie
Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability. Canonically, FMRP functions as an mRNA-binding translation suppressor, but recent findings have enormously expanded its proposed roles. Although connections between burgeoning FMRP functions remain unknown, recent advances have extended understanding of its involvement in RNA, channel, and protein binding that modulate calcium signaling, activity-dependent critical period development, and the excitation-inhibition (E/I) neural circuitry balance...
October 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28819289/escrt-iii-membrane-trafficking-misregulation-contributes-to-fragile-x-syndrome-synaptic-defects
#10
Dominic J Vita, Kendal Broadie
The leading cause of heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP). In the Drosophila FXS disease model, we found FMRP binds shrub mRNA (human Chmp4) to repress Shrub expression, causing overexpression during the disease state early-use critical period. The FXS hallmark is synaptic overelaboration causing circuit hyperconnectivity. Testing innervation of a central brain learning/memory center, we found FMRP loss and Shrub overexpression similarly increase connectivity...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818232/review-of-the-endothelial-pathogenic-mechanism-of-tie2-related-venous-malformation
#11
REVIEW
Zhong Du, JiaWei Zheng, ZhiYuan Zhang, YanAn Wang
BACKGROUND: Venous malformation (VM) is a type of disease involving vascular morphogenesis in humans. Clinically, VM can be sporadic or inherited. TIE2, also known as TEK or HYK, is a member of the receptor tyrosine kinase subfamily and is highly conserved among species. In 1996, an arginine-to-tryptophan substitution at position 849 (R849W) in TIE2 was found to induce hereditary VM. Additional alterations in TIE2 involved in the pathogenesis of inherited or sporadic VM have since been reported...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28814539/forward-a-registry-and-longitudinal-clinical-database-to-study-fragile-x-syndrome
#12
Stephanie L Sherman, Sharon A Kidd, Catharine Riley, Elizabeth Berry-Kravis, Howard F Andrews, Robert M Miller, Sharyn Lincoln, Mark Swanson, Walter E Kaufmann, W Ted Brown
BACKGROUND AND OBJECTIVE: Advances in the care of patients with fragile X syndrome (FXS) have been hampered by lack of data. This deficiency has produced fragmentary knowledge regarding the natural history of this condition, healthcare needs, and the effects of the disease on caregivers. To remedy this deficiency, the Fragile X Clinic and Research Consortium was established to facilitate research. Through a collective effort, the Fragile X Clinic and Research Consortium developed the Fragile X Online Registry With Accessible Research Database (FORWARD) to facilitate multisite data collection...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28812997/distribution-of-fmr1-and-fmr2-repeats-in-argentinean-patients-with-primary-ovarian-insufficiency
#13
Lucía Daniela Espeche, Violeta Chiauzzi, Ianina Ferder, Mehrnoosh Arrar, Andrea Paula Solari, Carlos David Bruque, Marisol Delea, Susana Belli, Cecilia Soledad Fernández, Noemí Delia Buzzalino, Eduardo Hernán Charreau, Liliana Beatriz Dain
The premutation state of FMR1 (Fragile X Mental Retardation 1) has been associated with primary ovarian insufficiency (POI), and is the most common known genetic cause for 46,XX patients. Nevertheless, very few studies have analyzed its frequency in Latin American populations. Additionally, a relationship between alleles carrying a cryptic microdeletion in the 5'UTR of FMR2 and the onset of POI has only been studied in one population. Our aim was to analyze the incidence of FMR1 premutations and putative microdeletions in exon 1 of FMR2 in a cohort of Argentinean women with POI...
August 16, 2017: Genes
https://www.readbyqxmd.com/read/28809834/quantifying-infra-slow-dynamics-of-spectral-power-and-heart-rate-in-sleeping-mice
#14
Laura M J Fernandez, Sandro Lecci, Romain Cardis, Gil Vantomme, Elidie Béard, Anita Lüthi
Three vigilance states dominate mammalian life: wakefulness, non-rapid eye movement (non-REM) sleep, and REM sleep. As more neural correlates of behavior are identified in freely moving animals, this three-fold subdivision becomes too simplistic. During wakefulness, ensembles of global and local cortical activities, together with peripheral parameters such as pupillary diameter and sympathovagal balance, define various degrees of arousal. It remains unclear the extent to which sleep also forms a continuum of brain states-within which the degree of resilience to sensory stimuli and arousability, and perhaps other sleep functions, vary gradually-and how peripheral physiological states co-vary...
August 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28799463/rebuilding-research-capacity-in-fragile-states-the-case-of-a-somali-swedish-global-health-initiative
#15
Abdirisak Ahmed Dalmar, Abdullahi Sheik Hussein, Said Ahmed Walhad, Abdirashid Omer Ibrahim, Abshir Ali Abdi, Mohamed Khalid Ali, Derie Ismail Ereg, Khadra Ali Egal, Abdulkadir Mohamed Shirwa, Mohamed Hussain Aden, Marian Warsame Yusuf, Yakoub Aden Abdi, Lennart Freij, Annika Johansson, Khalif Bile Mohamud, Yusuf Abdulkadir, Maria Emmelin, Jaran Eriksen, Kerstin Erlandsson, Lars L Gustafsson, Anneli Ivarsson, Marie Klingberg-Allvin, John Kinsman, Carina Källestål, Mats Målqvist, Fatumo Osman, Lars-Åke Persson, Klas-Göran Sahlén, Stig Wall
This paper presents an initiative to revive the previous Somali-Swedish Research Cooperation, which started in 1981 and was cut short by the civil war in Somalia. A programme focusing on research capacity building in the health sector is currently underway through the work of an alliance of three partner groups: six new Somali universities, five Swedish universities, and Somali diaspora professionals. Somali ownership is key to the sustainability of the programme, as is close collaboration with Somali health ministries...
2017: Global Health Action
https://www.readbyqxmd.com/read/28798680/striatal-network-models-of-huntington-s-disease-dysfunction-phenotypes
#16
Pengsheng Zheng, James Kozloski
We present a network model of striatum, which generates "winnerless" dynamics typical for a network of sparse, unidirectionally connected inhibitory units. We observe that these dynamics, while interesting and a good match to normal striatal electrophysiological recordings, are fragile. Specifically, we find that randomly initialized networks often show dynamics more resembling "winner-take-all," and relate this "unhealthy" model activity to dysfunctional physiological and anatomical phenotypes in the striatum of Huntington's disease animal models...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28797939/informal-assistance-to-urban-families-and-the-risk-of-household-food-insecurity
#17
Christian King
RATIONALE: Food insecurity is a persistent social problem affecting one out of eight households in the United States. While evidence shows that public assistance programs (formal assistance) are effective in reducing food insecurity, there is more limited evidence documenting how informal support, through social capital, affects food insecurity. OBJECTIVE: To examine the role of informal support (through instrumental social support, social cohesion, social control, and social participation) on food insecurity transitions using longitudinal data of a sample of disadvantaged urban mothers from the Fragile Families and Child Wellbeing Study...
August 2, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28771973/trends-and-determinants-of-osteoporosis-treatment-and-screening-in-patients-with-rheumatoid-arthritis-compared-to-osteoarthritis
#18
Gulsen Ozen, Diane L Kamen, Ted R Mikuls, Bryant R England, Frederick Wolfe, Kaleb Michaud
OBJECTIVE: To profile osteoporosis (OP) care in patients with rheumatoid arthritis (RA) over the past decade. METHODS: Patients with RA or osteoarthritis (OA) were followed from 2003 through 2014. OP care was defined as receipt of OP treatment (with exception of calcium/vitamin D) or screening (OPTS). Adjusted trends over follow-up, and the factors associated with OP care were examined using the multivariable Cox proportional hazards. RESULTS: OPTS was reported in 67...
August 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28752476/bleeding-risk-with-invasive-procedures-in-patients-with-cirrhosis-and-coagulopathy
#19
REVIEW
Nekisa Zakeri, Emmanuel A Tsochatzis
PURPOSE OF REVIEW: Previous perceptions of cirrhosis as a hypocoagulable state have resulted in empirical blood product transfusions prior to invasive procedures. We evaluate procedure-related bleeding risks in patients with cirrhosis, assess the utility of conventional and newer global coagulation tests, and explore evidence surrounding prophylactic transfusion strategies. RECENT FINDINGS: Recent literature supports the concept of a rebalanced, albeit fragile, haemostasis equilibrium in cirrhosis, with a potential hypercoagulable tendency in stable patients...
September 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28742547/celiprolol-a-unique-selective-adrenoceptor-modulator
#20
James J Nawarskas, Angela Cheng-Lai, William H Frishman
Celiprolol is a β-blocker with a unique pharmacologic profile: it is a β1-andrenoceptor antagonist with partial β2 agonist activity. Given this combination of effects, celiprolol may be better described as a selective adrenoreceptor modulator. It has antihypertensive and antianginal properties and is indicated for those uses in various countries around the world. In the United States, however, the proposed indication for this drug will be for the treatment of vascular type Ehlers-Danlos syndrome, a rare connective tissue disorder characterized by fragile arterial structure and an increased risk of life-threatening vascular complications...
September 2017: Cardiology in Review
keyword
keyword
50436
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"