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https://www.readbyqxmd.com/read/29775702/abnormal-sleep-architecture-and-hippocampal-circuit-dysfunction-in-a-mouse-model-of-fragile-x-syndrome
#1
Christine E Boone, Heydar Davoudi, Jon B Harrold, David J Foster
Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and single-gene cause of autism spectrum disorder. The Fmr1 null mouse models much of the human disease including hyperarousal, sensory hypersensitivity, seizure activity, and hippocampus-dependent cognitive impairment. Sleep architecture is disorganized in FXS patients, but has not been examined in Fmr1 knockout (Fmr1-KO) mice. Hippocampal neural activity during sleep, which is implicated in memory processing, also remains uninvestigated in Fmr1-KO mice...
May 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29760963/effectiveness-of-a-day-rehabilitation-program-in-improving-functional-outcome-and-reducing-mortality-and-readmission-of-elderly-patients-with-fragility-hip-fractures
#2
Tak Man Wong, Frankie K L Leung, Tak Wing Lau, Christian Fang, Felix H W Chan, Jun Wu
Introduction: The incidence of hip fracture is projected to increase in the next 25 years as the world population ages. Hip fracture is often associated with subsequent readmission and mortality. Nevertheless, elderly patients often may not achieve the same level of functional ability as prior to their injury. Several studies have shown that close collaboration between orthopedic surgeons and geriatricians can improve such outcomes and Geriatric Day Hospital (GDH) is one of the examples of collaboration to improve such outcomes...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29749047/versatile-ferroelastic-deformability-in-an-organic-single-crystal-by-twinning-about-a-molecular-zone-axis
#3
Emile R Engel, Satoshi Takamizawa
Ferroelasticity involves the generation of spontaneous strain in a solid by the application of mechanical stress. The phenomenon has been well-studied in metal alloys but relatively neglected in organic solid-state chemistry. Here we present multiple discrete modes of mechanical twinning and a mechanistic analysis of ferroelasticity in 1,4-diethoxybenzene. Single crystals of the compound can be almost freely deformed, as multiple different twin domains are generated simultaneously. Within each domain, single-crystal character is preserved...
May 10, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29747785/critical-care-nurses-experiences-of-performing-successful-peripheral-intravenous-catheterization-in-difficult-situations
#4
Angelica Forsberg, Åsa Engström
The aim of this study is to describe the experiences of critical care nurses (CCNs) when performing successful peripheral intravenous catheterization (PIVC) on adult inpatients in difficult situations. This study uses a descriptive design with a qualitative approach. Semistructured interviews were given to CCNs (n = 22) at a general central county hospital in northern Sweden. The interview text was analyzed with qualitative thematic content analysis. Three themes emerged: "releasing time and creating peace," "feeling self-confidence in the role of expert nurse," and "technical interventions promoting success...
June 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29746258/gi-bleeding-during-cf-lvad-support-state-of-the-field
#5
Rachna Kataria, Ulrich P Jorde
Continuous-flow left ventricular assist devices (CF-LVADs) are increasingly used for the management of advanced heart failure refractory to optimal medical therapy. Despite the encouraging outcomes with CF-LVADs, gastrointestinal bleeding (GIB) continues to be a rather concerning complication resulting in increased rates of readmission and increased morbidity. The exact pathophysiology of CF-LVAD associated GIB remains poorly understood and this lack of knowledge limits our ability to control this morbid complication...
May 9, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29741198/the-use-of-figurative-language-to-describe-frailty-in-older-adults
#6
B Buta, D Leder, R Miller, N L Schoenborn, A R Green, R Varadhan
INTRODUCTION: Frailty affects 15% of non-institutionalized older adults in the United States, yet confusion remains in defining and, in turn, assessing frailty. Figurative language, such as metaphor, can help to explain difficult scientific concepts and to form new theories. We aimed to examine the use of figurative language to describe frailty and to identify themes in the way figurative expressions are used. Understanding how frailty is described figuratively may offer insights for developing useful communication approaches in research settings...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29717310/stereodynamic-insight-into-the-thermal-history-effects-on-poly-vinyl-chloride-calorimetric-sub-glass-and-glass-transitions-as-a-fragile-glass-model
#7
Jean-Mathieu Pin, Ehsan Behazin, Manjusri Misra, Amar Mohanty
The dynamic thermal history impact of poly(vinyl chloride) (PVC) has been explored for a wide range of pre-cooling rates, from 1 to 30 °C min-1. A first macroscopic insight into the dynamic thermal history influence has been highlighted through a decrease in the apparent activation energy (Eapp) in the first stage of the glass transition. The overall glass transition Eapp surface was successfully modeled in a polynomial fashion regarding the pre-cooling range. Raman scattering was used to associate the Eapp variations along the glass transition conversion with the stereochemistry evolution during the polymeric relaxation...
May 2, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29710770/exercise-early-and-often-effects-of-physical-activity-and-exercise-on-women-s-bone-health
#8
REVIEW
Karen L Troy, Megan E Mancuso, Tiffiny A Butler, Joshua E Johnson
In 2011 over 1.7 million people were hospitalized because of a fragility fracture, and direct costs associated with osteoporosis treatment exceeded 70 billion dollars in the United States. Failure to reach and maintain optimal peak bone mass during adulthood is a critical factor in determining fragility fracture risk later in life. Physical activity is a widely accessible, low cost, and highly modifiable contributor to bone health. Exercise is especially effective during adolescence, a time period when nearly 50% of peak adult bone mass is gained...
April 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29706779/why-be-red-listed-threatened-myriapoda-species-in-brazil-with-implications-for-their-conservation
#9
Manoela Karam-Gemael, Thiago Junqueira Izzo, Amazonas Chagas-Jr
The biodiversity crisis we live in, marked by high extinction rates, requires well-planned conservation efforts. To overcome this issue, red lists of threatened species are recognized as the main objective approach for evaluating the conservation status of species and therefore guiding conservation priorities. This work focuses on the Myriapoda (Chilopoda and Diplopoda) species listed in the Brazilian red list of fauna to enable discussion of the practical implications of red lists for conservation. Almost all myriapods assessed are endemic to Brazil (99 %) and 73 % are known from subterranean habitats only...
2018: ZooKeys
https://www.readbyqxmd.com/read/29704027/implementation-of-the-western-australian-osteoporosis-model-of-care-a-fracture-liaison-service-utilising-emergency-department-information-systems-to-identify-patients-with-fragility-fracture-to-improve-current-practice-and-reduce-re-fracture-rates-a-12-month
#10
C A Inderjeeth, W D Raymond, A M Briggs, E Geelhoed, D Oldham, D Mountain
Fracture liaison service linked to an emergency department database effectively identifies patients with OP, improves best practice care, reduces recurrent fractures, and improves quality of life (QoL). The next step is to establish cost-effectiveness. This should be seen as the standard model of care. INTRODUCTION: The Western Australian Osteoporosis Model of Care recommends implementation of a fracture liaison service (FLS) to manage patients with minimal trauma fractures (MTFs). This study evaluates the efficacy of a FLS linked to a tertiary hospital emergency department information system (EDIS) in reducing recurrent fractures...
April 27, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29699433/prescription-drug-misuse-and-child-maltreatment-among-high-risk-families
#11
Jennifer Price Wolf
Prescription drug misuse is increasingly common in the United States. To date, little is known about how prescription drug misuse relates to negative parenting behaviors like child maltreatment, even though use of illicit drugs increases rates of both child neglect and physical abuse. This study used secondary data from the Fragile Families and Child Well-Being Study (FFCWS), a clustered national sample of families at high risk for both prescription drug misuse and child maltreatment ( n = 2,917). Data from mothers who participated in the 9-year follow-up of this study were used to create logistic regression models examining prescription drug misuse and physically aggressive and neglectful parenting, while controlling for demographic and psychosocial variables...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29693614/poly-urethane-norbornene-aerogels-via-ring-opening-metathesis-polymerization-of-dendritic-urethane-norbornene-monomers-structure-property-relationships-as-a-function-of-an-aliphatic-versus-an-aromatic-core-and-the-number-of-peripheral-norbornene-moieties
#12
Aspasia Kanellou, George C Anyfantis, Despoina Chriti, Grigorios Raptopoulos, Marinos Pitsikalis, Patrina Paraskevopoulou
We report the synthesis and characterization of synthetic polymer aerogels based on dendritic-type urethane-norbornene monomers. The core of those monomers is based either on an aromatic/rigid (TIPM/Desmodur RE), or an aliphatic/flexible (Desmodur N3300) triisocyanate. The terminal norbornene groups (three at the tip of each of the three branches) were polymerized via ROMP using the inexpensive 1st generation Grubbs catalyst. The polymerization/gelation conditions were optimized by varying the amount of the catalyst...
April 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29690268/a-new-species-of-cave-dwelling-neocarus-acari-opilioacaridae-from-bahia-state-brazil-with-remarks-on-taxonomic-characters
#13
Marcel Santos De araÚjo, Maria Elina Bichuette, Gary R Bauchan, Ronald Ochoa, Reinaldo josÉ Fazzio Feres
Neocarus coronatus n. sp., is described from caves and the surrounding epigean habitats from a karst area of São Desidério county, Bahia state, Brazil. A dissection procedure is presented for the better use of scarce Opilioacaridae material, especially to analyze gut contents. Sexual dimorphism is presented, mainly differences in the density of setae on the dorsal shield in the prominent triangular anterior region. Females have an ovipositor with 3 pairs of smooth digitiform projections and 6-8 eugenital setae...
March 28, 2018: Zootaxa
https://www.readbyqxmd.com/read/29668023/common-queries-about-immunizations-in-preterm-infants
#14
Ansul Asad
Preterm infants are at an increased risk of morbidity and mortality from vaccine-preventable diseases. Despite this, delays in routine immunization of preterm infants are common. Available guidelines clearly state that they should be immunized according to chronological age, irrespective of gestational age and birth weight or current weight. In this article, we try to assuage parental and provider doubts by reviewing data about immunogenicity, safety, and responses to routine immunizations in preterm infants with and without comorbidities...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29658144/bone-fragility-in-turner-syndrome-fracture-prevalence-and-risk-factors-determined-by-a-national-patient-survey
#15
Halley Wasserman, Philippe F Backeljauw, Jane C Khoury, Heidi J Kalkwarf, Catherine M Gordon
OBJECTIVE: Osteoporosis is considered a comorbidity of adult women with Turner Syndrome (TS). Limited data are available on fracture prevalence in girls and women with this diagnosis. We aimed to determine the prevalence of fractures in individuals with TS in the United States and identify risk factors for fracture. DESIGN: Girls and women with TS were invited to participate in an anonymous, self-report, national survey from November 2016 to March 2017. Non-TS controls were obtained through direct contacts of TS participants...
April 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29657087/the-pediatric-aerodigestive-center-as-a-tertiary-care-based-medical-home-a-proposed-model
#16
Meghan M Galligan, Tara W Bamat, Annique K Hogan, Joseph Piccione
Children with special healthcare needs have been identified nationally as a population whose health care is associated with unmet needs; increased morbidity; fragmentation of care and medical errors; caregiver dissatisfaction; and disproportionately high costs. A subset of these children are medically fragile, with medical complexity that requires a reliance on tertiary care-based services-including subspecialty appointments, surgical procedures, and care coordination resources. For medically complex patients affected by upper and lower respiratory tract and gastrointestinal disorders, multidisciplinary aerodigestive centers have emerged at tertiary care centers across the United States to facilitate coordinated, high-quality, and high value care...
April 12, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29651485/structural-signature-and-transition-dynamics-of-sb-2-te-3-melt-upon-fast-cooling
#17
Y R Guo, F Dong, C Qiao, J J Wang, S Y Wang, Ming Xu, Y X Zheng, R J Zhang, L Y Chen, C Z Wang, K M Ho
Crystalline Sb2Te3 is widely studied due to its important applications in memory materials and topological insulators. The liquid and amorphous structures of this compound as well as the dynamics upon quenching, however, are yet to be fully understood. In this work, we have systematically studied the dynamical properties and local structure of Sb2Te3 at different temperatures using ab initio molecular dynamics simulations. The calculated structure factors agree well with the experimental results. The atomic number density and mean-squared displacement as a function of temperature clearly indicate three states as the temperature decreases, namely, melt, undercooled liquid and glass state, respectively...
April 13, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29650460/how-does-an-animal-behave-like-a-plant-physiological-and-molecular-adaptations-of-zooxanthellae-and-their-hosts-to-symbiosis
#18
Denis Allemand, Paola Furla
Cnidarians (corals and sea anemones) harbouring photosynthetic microalgae derive several benefits from their association. To allow this association, numerous symbiotic-dependent adaptations in both partners, resulting from evolutionary pressures, have been selected. The dinoflagellate symbionts (zooxanthellae) are located inside a vesicle in the cnidarian host cell and are therefore exposed to a very different environment compared to the free-living state of these microalgae in terms of ion concentration and carbon content and speciation...
April 9, 2018: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29623788/on-the-occurrence-of-the-invasive-freshwater-limpet-ferrissia-californica-mollusca-gastropoda-planorbidae-in-japan
#19
Luca Vecchioni, Federico Marrone, Marco Arculeo, Victor Benno Meyer-Rochow
Two members of the genus Ferrissia Walker, 1903, namely Ferrissia nipponica (Kuroda, 1949) and F. japonica Habe and Burch, 1965, have been reported to occur in Japan, but due to a lack of molecular data, doubts have been expressed as to their validity. Furthermore, the possible presence of allochthonous Ferrissia taxa has been stated under a variety of names, so that even now there is no consensus on their presence and identity. Recently, freshwater limpets belonging to the planorbid genus Ferrissia were collected in an irrigation trough on the Izu island of Hachijōjima, Tokyo, Japan...
April 2018: Zoological Science
https://www.readbyqxmd.com/read/29623238/the-effectiveness-of-osteoporosis-screening-and-treatment-in-the-midwest
#20
Dharmik Patel, John R Worley, David A Volgas, Brett D Crist
Introduction: With osteoporosis on the rise across the United States, the goal of this prospective study is to determine the effectiveness of our Midwest level-1 trauma center in diagnosing, treating, and educating osteoporosis patients after fracture with the use of questionnaires. Secondarily, we aimed to identify barriers that prevent our patients from complying with bone health recommendations. Methods: One hundred participants (≥55 years) were given 2 questionnaires (Fracture Risk Assessment Tool and a study-specific questionnaire) that were administered during the patient's visit to the orthopedic trauma clinic...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
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