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https://www.readbyqxmd.com/read/29690947/united-nations-charter-chapter-vii-article-43-now-or-never
#1
Frederick M Burkle
For more than 75 years, the United Nations Charter has functioned without the benefit of Chapter VII, Article 43, which commits all United Nations member states "to make available to the Security Council, on its call, armed forces, assistance, facilities, including rights of passage necessary for the purpose of maintaining international peace and security." The consequences imposed by this 1945 decision have had a dramatic negative impact on the United Nation's functional capacity as a global body for peace and security...
April 25, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29688552/haemodialysis-or-haemodiafiltration-that-is-the-question
#2
Francesco Locatelli, Fabio Carfagna, Lucia Del Vecchio, Vincenzo La Milia
Despite the technological and pharmacological advancements in the last 30 years, morbidity and mortality of dialysis patients are still astonishingly high. Today, convective treatments, such as high-flux haemodialysis (hf-HD) and haemodiafiltration (HDF), are established techniques; the online production of fresh pure dialysate has provided clinical and economic advantages. Nevertheless, the actual benefits of HDF, even with high-convective-volume treatments, are still debatable. Three recent, randomized controlled trials compared survival outcomes in prevalent patients receiving conventional HD or post-dilution HDF and reported conflicting results...
April 24, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29685630/symptomatic-medulla-compression-by-vertebral-artery
#3
Leszek Lombarski, Przemysław Kunert, Marcin Skawiński, Marek Prokopienko, Zbigniew Lewandowski, Andrzej Marchel
OBJECTIVE: Vertebral artery medulla compression syndrome (VAMCS) is a very rare condition manifesting as different neurological focal deficits. The case of a 36-year-old male with symptomatic brainstem compression by vertebral artery (VA) treated by means of microvascular decompression (MVD) and a review of the literature is presented. CASE REPORT: On admission, a 36-year-old patient presented with hypoalgesia, hypothermesthesia and hemiparesis on the left side...
March 17, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29685059/hamstring-muscle-use-in-females-during-hip-extension-and-the-nordic-hamstring-exercise-an-fmri-study
#4
Daniel J Messer, Matthew N Bourne, Morgan D Williams, Aiman Al Najjar, Anthony J Shield
Study Design Cross-sectional study. Background Understanding hamstring muscle activation patterns in resistance training exercises may have implications for the design of strength training and injury prevention programs. Unfortunately, surface electromyography studies have reported conflicting results with regard to hamstring muscle activation patterns in women. Objectives To determine the spatial patterns of hamstring muscle activity during the 45º hip-extension and Nordic hamstring exercises, in females using functional magnetic resonance imaging...
April 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#5
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29681624/rapid-on-site-evaluation-during-endoscopic-ultrasound-guided-fine-needle-aspiration-of-lymph-nodes-does-not-increase-diagnostic-yield-a-randomized-multicenter-trial
#6
W F W Kappelle, M E Van Leerdam, M P Schwartz, M Bülbül, W A Buikhuisen, M A Brink, D M D S Sie-Go, H J M Pullens, S Nikolakopoulos, P J Van Diest, M Leenders, L M G Moons, A Bogte, P D Siersema, F P Vleggaar
OBJECTIVES: Studies on the impact of rapid on-site evaluation (ROSE) during endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of lymph nodes are retrospective and have shown conflicting results. We aimed to compare the diagnostic yield of EUS-FNA of lymph nodes with ROSE (ROSE+) and without ROSE (ROSE-). METHODS: This was a multicenter, randomized controlled trial. Consecutive patients who were scheduled to undergo EUS-FNA of mediastinal or abdominal lymph nodes were randomized to ROSE+ or ROSE-...
April 23, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29679820/joy-guilt-and-disappointment-an-interpretative-phenomenological-analysis-of-the-experiences-of-women-transferred-from-midwifery-led-to-consultant-led-care
#7
Patricia Larkin
BACKGROUND: Irish maternity services are predominantly medicalised and consultant led, therefore women who choose midwifery led care (MLC) do so in the context of limited birth choices. Transfers to consultant led unit (CLU) for consultant led care (CLC) can be unpredictable and can affect women's birth experiences. This study provides an in-depth exploration of women's experiences of transfer fromMLC to CLC during late pregnancy or labour. METHODS: Transfer experiences are explored through qualitative explorative in-depth interviews using interpretative phenomenological analysis (IPA)...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29679730/stand-alone-lateral-lumbar-interbody-fusion-for-the-treatment-of-symptomatic-adjacent-segment-degeneration-following-previous-lumbar-fusion
#8
Philip K Louie, Arya G Varthi, Ankur S Narain, Victor Lei, Daniel D Bohl, Grant D Shifflett, Frank M Phillips
BACKGROUND CONTEXT: Revision posterior decompression and fusion for patients with symptomatic ASD is associated with significant morbidity and is technically challenging. The use of a stand-alone LLIF in patients with symptomatic ASD may avoid many of the complications associated with revision posterior surgery. PURPOSE: To assess the clinical and radiographic outcomes of patients who underwent stand-alone lateral lumbar interbody fusion (LLIF) for symptomatic adjacent segment disease (ASD)...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29673578/diagnosis-of-primary-hemifacial-spasm
#9
J-P Lefaucheur, N Ben Daamer, S Sangla, C Le Guerinel
The diagnosis of primary hemifacial spasm (pHFS), due to a benign compression of the facial motor nerve by a vessel, within or close to its root exit zone, is often made with delay. Misdiagnosis includes psychogenic spasm, tics, facial myokymia or blepharospasm, but in fact post-facial palsy synkinesis (post-paralytic HFS) is the closest clinical condition, because it is limited to the territory of the facial nerve of a single hemiface. The differential diagnosis between these two entities, whose pathophysiological mechanisms are very different, can be made by electroneuromyographic (ENMG) examination...
April 16, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29669163/clinical-differences-between-elderly-onset-and-non-elderly-onset-ulcerative-colitis-a-nationwide-survey-data-in-japan
#10
Shunsuke Komoto, Masaaki Higashiyama, Chikako Watanabe, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Toru Takebayashi, Keiko Asakura, Yuji Nishiwaki, Soichiro Miura, Ryota Hokari
OBJECTIVE: Studies on the characteristics of elderly-onset ulcerative colitis (EOUC) and non-elderly-onset UC (NEOUC) have reported conflicting findings. The aim of this study was to compare disease characteristics of EOUC and NEOUC by analyzing the database of the Japanese nationwide inflammatory bowel disease (IBD) registry. STUDY DESIGN: We analyzed the age of disease onset, sex, disease severity, and disease extent in patients with UC that were newly diagnosed and registered within one year between 2004 and 2009 (N = 28,179)...
April 18, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29667736/commentary-advancing-an-implementation-science-agenda-on-mental-health-and-psychosocial-responses-in-war-affected-settings-comment-on-trials-of-a-psychosocial-intervention-for-youth-affected-by-the-syrian-crisis-by-panter-brick-et-al-2018
#11
Theresa S Betancourt, Mina Fazel
Syria's civil conflict has created the largest humanitarian disaster of our time, causing massive population displacement, tremendous exposure to trauma, and loss. Advancing the mental health and psychosocial responses of war-affected populations both during acute humanitarian emergencies and in post-conflict transition is imperative in forging a constructive implementation agenda. This study makes an important contribution in building evidence toward effective interventions to advance the mental health and well-being of those affected by the Syrian crisis...
May 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29667092/intraoperative-pyloric-interventions-during-oesophagectomy-a-multicentre-study
#12
Salvatore Marchese, Yassar A Qureshi, Shazia P Hafiz, Khaled Dawas, Paul Turner, M Muntzer Mughal, Borzoueh Mohammadi
BACKGROUND: Denervation of the pylorus after oesophagectomy is considered the principal factor responsible for delayed gastric emptying. Several studies have attempted to delineate whether surgical or chemical management of the pylorus during oesophagectomy is of benefit, but with conflicting results. The aim of this multicentre study was to assess whether there was any difference in outcomes between different approaches to management of the pylorus. METHODS: A prospectively maintained database was used to identify patients who underwent oesophagectomy for malignancy...
April 17, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29665873/impact-of-paternal-deployment-to-the-conflicts-in-iraq-and-afghanistan-and-paternal-post-traumatic-stress-disorder-on-the-children-of-military-fathers
#13
Nicola T Fear, Ruth V Reed, Sarah Rowe, Howard Burdett, David Pernet, Alyson Mahar, Amy C Iversen, Paul Ramchandani, Alan Stein, Simon Wessely
BACKGROUND: Little is known about the social and emotional well-being of children whose fathers have been deployed to the conflicts in Iraq/Afghanistan or who have post-traumatic stress disorder (PTSD).AimsTo examine the emotional and behavioural well-being of children whose fathers are or have been in the UK armed forces, in particular the effects of paternal deployment to the conflicts in Iraq or Afghanistan and paternal PTSD. METHOD: Fathers who had taken part in a large tri-service cohort and had children aged 3-16 years were asked about the emotional and behavioural well-being of their child(ren) and assessed for symptoms of PTSD via online questionnaires and telephone interview...
April 18, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29665764/unicompartmental-knee-arthroplasty-for-spontaneous-osteonecrosis-of-the-knee-a-meta-analysis
#14
Julio J Jauregui, Christopher L Blum, Neil Sardesai, Craig Bennett, R Frank Henn, Farshad Adib
BACKGROUND: Spontaneous osteonecrosis of the knee (SONK) is a poorly understood but debilitating disease entity. Total knee arthroplasty (TKA) is the standard of care for those patients who fail conservative management, but considering SONK's predilection for affecting a single knee compartment, unicompartmental knee arthroplasty (UKA) appears to be a more tailored option. Unfortunately, conflicting data exist on the utility of UKA in SONK. Thus, the purpose of this study was to evaluate functional outcomes and revision rates of UKA in the setting of SONK...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29665079/calming-an-aggressor-through-spontaneous-post-conflict-triadic-contacts-appeasement-in-macaca-tonkeana
#15
Virginia Pallante, Roscoe Stanyon, Elisabetta Palagi
Peaceful third-party interventions usually occur after an aggressive encounter and can be directed toward the victim or the aggressor. Macaca tonkeana, a cercopithecine species characterized by high levels of tolerance, frequently engage in consolatory contacts, which both calm the victim and reduce the probability of further attacks against him/her. Other post-conflict affiliative interventions such as reconciliation and quadratic affiliation are also common in this species. However, little attention has been given to contacts directed toward the aggressor...
April 17, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29659893/temporal-mitogenomics-of-the-galapagos-giant-tortoise-from-pinz%C3%A3-n-reveals-potential-biases-in-population-genetic-inference
#16
Evelyn L Jensen, Joshua M Miller, Danielle L Edwards, Ryan C Garrick, Washington Tapia, Adalgisa Caccone, Michael A Russello
Empirical population genetic studies generally rely on sampling subsets of the population(s) of interest and of the nuclear or organellar genome targeted, assuming each are representative of the whole. Violations of these assumptions may impact population-level parameter estimation and lead to spurious inferences. Here we used targeted capture to sequence the full mitochondrial genome from 123 individuals of the Galapagos giant tortoise endemic to Pinzón Island (Chelonoidis duncanensis) sampled at two time points pre- and post-bottleneck (circa 1906 and 2014) to explicitly assess differences in diversity estimates and demographic reconstructions based on subsets of the mitochondrial genome versus the full sequences, and to evaluate potential biases associated with diversity estimates and demographic reconstructions from post-bottlenecked samples alone...
April 6, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29659826/association-between-ambient-air-pollution-and-pregnancy-rate-in-women-who-underwent-ivf
#17
S A Choe, Y B Jun, W S Lee, T K Yoon, S Y Kim
STUDY QUESTION: Are the concentrations of five criteria air pollutants associated with probabilities of biochemical pregnancy loss and intrauterine pregnancy in women? SUMMARY ANSWER: Increased concentrations of ambient particulate matter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO) during controlled ovarian stimulation (COS) and after embryo transfer were associated with a decreased probability of intrauterine pregnancy. WHAT IS KNOWN ALREADY: Exposure to high ambient air pollution was suggested to be associated with low fertility and high early pregnancy loss in women...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29658279/-the-professional-and-family-characteristics-difficulties-contentment-and-resources-of-physicians-working-at-level-3-neonatal-intensive-care-centres-general-overview-in-hungary
#18
Zsuzsanna Soósné Kiss, Helga Judit Feith, Miklós Szabó, Edina Gradvohl
INTRODUCTION: A survey that investigates the situation of physicians working at neonatal intensive care (NIC) centres has not been made since 1997. AIM: To give an overview of the sociodemographic characteristics; personal and professional problems; the satisfaction with their job and family roles; their levels of healthy lifestyle; resources in the families of physicians working at NIC. METHOD: We have made an examination in Hungary at NIC among physicians from April 2015 till January 2016, with an anonym self-fill-in questionnaire...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29650555/noninfectious-lung-complications-after-allogeneic-haematopoietic-stem-cell-transplantation
#19
Anne Bergeron, Sylvie Chevret, Régis Peffault de Latour, Karine Chagnon, Constance de Margerie-Mellon, Frédéric Rivière, Marie Robin, Jean Mani, Gwenael Lorillon, Gérard Socié, Abdellatif Tazi
Epidemiological data on late noninfectious pulmonary complications (LONIPCs) following allogeneic haematopoietic stem cell transplantation (HSCT) are derived exclusively from retrospective studies and conflicting. We aimed to evaluate prospectively their incidence, risk factors and outcomes.All consecutive patients scheduled to receive allogeneic HSCT between 2006 and 2008, at the university-teaching Saint Louis Hospital (Paris, France) were screened for inclusion. Eligible patients were those surviving at day 100...
April 12, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29644076/lost-in-translation-the-3-utr-of-igf1r-as-an-ancient-long-noncoding-rna
#20
Avantika Mainieri, David Haig
Background and objectives: The insulin-like growth factor (IGF) signaling system is a major arena of intragenomic conflict over embryonic growth between imprinted genes of maternal and paternal origin and the IGF type 1 receptor (IGF1R) promotes proliferation of many human cancers. The 3'-untranslated region (3'-UTR) of the mouse Igf1r mRNA is targeted by miR-675-3p derived from the imprinted H19 long noncoding RNA. We undertook a comparative sequence analysis of vertebrate IGF1R 3'-UTRs to determine the evolutionary history of miR-675 target sequences and to identify conserved features that are likely to be involved in post-transcriptional regulation of IGF1R translation...
2018: Evolution, Medicine, and Public Health
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