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https://www.readbyqxmd.com/read/28650108/a-matched-pair-analysis-of-multicenter-long-term-follow-up-after-split-liver-transplantation-with-extended-right-grafts
#1
M W Ross, M Cescon, R Angelico, E Andorno, G Rossi, A Pinna, L De Carlis, U Baccarani, U Cillo, M Colledan, V Mazzaferro, G Tisone, M Rossi, F Tuzzolino, D Pagano, S Gruttadauria, G Mazariegos, B Gridelli, M Spada
Split liver transplantation has been proposed as an alternative to whole liver transplantation to expand the donor pool, but studies comparing adult long-term outcomes between the two methods are conflicting and limited. This is the first Italian multicenter study that retrospectively analyzed 119 matched-pair recipients of whole and extended right grafts for long-term survival outcomes. In the overall population, whole liver recipients showed higher patient survival at one- (93% vs. 73%), five- (87% vs. 65%) and ten-year (83% vs...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650073/short-term-effectiveness-of-a-relationship-education-program-for-distressed-military-couples-in-the-context-of-foreign-assignments-for-the-german-armed-forces-preliminary-findings-from-a-randomized-controlled-study
#2
Christoph Kröger, Sören Kliem, Peter Zimmermann, Jens Kowalski
This study examines the short-term effectiveness of a relationship education program designed for military couples. Distressed couples were randomly placed in either a wait-list control group or an intervention group. We conducted training sessions before a 3-month foreign assignment, and refresher courses approximately 6-week post-assignment. We analyzed the dyadic data of 32 couples, using hierarchical linear modeling in a two-level model. Reduction in unresolved conflicts was found in the intervention group, with large pre-post effects for both partners...
June 26, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28646586/vaccine-candidate-discovery-for-the-next-generation-of-malaria-vaccines
#3
REVIEW
James Tuju, Gathoni Kamuyu, Linda M Murungi, Faith H A Osier
Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post- genomic era. Probing of genomic and/or cDNA libraries with antibodies of defined specificities or functional activity predominated the former, while reverse vaccinology encompassing high throughput in silico analyses of genomic, transcriptomic or proteomic parasite datasets is the mainstay of the latter...
June 24, 2017: Immunology
https://www.readbyqxmd.com/read/28646509/resistance-to-group-clinical-supervision-a-semistructured-interview-study-of-non-participating-mental-health-nursing-staff-members
#4
Niels Buus, Cynthia Delgado, Michael Traynor, Henrik Gonge
This present study is a report of an interview study exploring personal views on participating in group clinical supervision among mental health nursing staff members who do not participate in supervision. There is a paucity of empirical research on resistance to supervision, which has traditionally been theorized as a supervisee's maladaptive coping with anxiety in the supervision process. The aim of the present study was to examine resistance to group clinical supervision by interviewing nurses who did not participate in supervision...
June 23, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28644607/electrochemical-exfoliation-of-graphite-in-aqueous-sodium-halide-electrolytes-towards-low-oxygen-content-graphene-for-energy-and-environmental-applications
#5
Jose Maria Munuera, Juan Ignacio Paredes, Marina Enterria, Ana Pagán, Silvia Villar-Rodil, Manuel Fernando R Pereira, J I Martins, José L Figueiredo, Jose Luis Cenis, Amelia Martinez-Alonso, Juan Manuel D Tascon
Graphene and graphene-based materials have shown great promise in many technological applications, but their large-scale production and processing by simple and cost-effective means still constitute significant issues in the path of their widespread implementation. Here, we investigate a straightforward method for the preparation of a ready-to-use and low oxygen content graphene material that is based on electrochemical (anodic) delamination of graphite in aqueous medium with sodium halides as the electrolyte...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28643553/renal-dysfunction-and-chronic-kidney-disease-in-ischemic-stroke-and-transient-ischemic-attack-a-population-based-study
#6
Derek Hayden, Christine McCarthy, Layan Akijian, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O' Rourke, David Williams, Sean Murphy, Yvonne O'Meara, Peter J Kelly
Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2) for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m(2), renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28637691/settling-the-m-6-a-debate-methylation-of-mature-mrna-is-not-dynamic-but-accelerates-turnover
#7
REVIEW
Nicolle A Rosa-Mercado, Johanna B Withers, Joan A Steitz
Post-transcriptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology. In this issue of Genes & Development, Ke and colleagues (pp. 990-1006) provide insights into the temporal and spatial distribution of N(6)-methyladenosine (m(6)A) in RNA transcripts by analyzing different subcellular fractions. Using a recently developed biochemical approach for detecting m(6)A, the researchers show that m(6)A methylations are enriched in exons and are added to transcripts prior to splicing...
May 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28637228/application-of-social-network-analysis-in-the-assessment-of-organization-infrastructure-for-service-delivery-a-three-district-case-study-from-post-conflict-northern-uganda
#8
Freddie Ssengooba, Vincent Kawooya, Justine Namakula, Suzanne Fustukian
In post-conflict settings, service coverage indices are unlikely to be sustained if health systems are built on weak and unstable inter-organization networks-here referred to as infrastructure. The objective of this study was to assess the inter-organization infrastructure that supports the provision of selected health services in the reconstruction phase after conflict in northern Uganda. Applied social network analysis was used to establish the structure, size and function among organizations supporting the provision of (1) HIV treatment, (2) maternal delivery services and (3) workforce strengthening...
June 16, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28631959/advance-care-planning-for-patients-with-amyotrophic-lateral-sclerosis
#9
Benjamin H Levi, Zachary Simmons, Courtney Hanna, Allyson Brothers, Erik Lehman, Elana Farace, Megan Bain, Renee Stewart, Michael J Green
PURPOSE: To determine whether an advance care planning (ACP) decision-aid could improve communication about end-of-life treatment wishes between patients with amyotrophic lateral sclerosis (ALS) and their clinicians. METHODS: Forty-four patients with ALS (>21, English-speaking, without dementia) engaged in ACP using an interactive computer based decision-aid. Before participants completed the intervention, and again three months later, their clinicians reviewed three clinical vignettes, and made treatment decisions (n = 18) for patients...
March 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28629428/study-protocol-evaluation-of-an-online-father-inclusive-universal-parenting-intervention-to-reduce-child-externalising-behaviours-and-improve-parenting-practices
#10
Lucy A Tully, Patrycja J Piotrowska, Daniel A J Collins, Kathleen S Mairet, David J Hawes, Eva R Kimonis, Rhoshel K Lenroot, Caroline Moul, Vicki Anderson, Paul J Frick, Mark R Dadds
BACKGROUND: Parenting interventions that focus on enhancing the quality and consistency of parenting are effective for preventing and reducing externalising problems in children. There has been a recent shift towards online delivery of parenting interventions in order to increase their reach and impact on the population prevalence of child externalising problems. Parenting interventions have low rates of father participation yet research suggests that father involvement may be critical to the success of the intervention...
June 19, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28625072/depression-and-anxiety-among-war-widows-of-nepal-a-post-civil-war-cross-sectional-study
#11
Syaron Basnet, Pragya Kandel, Prabhat Lamichhane
Thousands of Nepalese women were widowed as a consequence of a decade (1996-2006) long civil war in Nepal. These women are at grave risk of mental health problems due to both traumatic experiences and violation of natural order of widowhood. The present study explores the depression and anxiety among war-widows. In 2012, a cross-sectional study was designed to interview 358 war-widows using validitated Beck Depression Inventory and Beck Anxiety Inventory in four districts of Nepal - Bardiya, Surkhet, Sindhupalchowk and Kavrepalanchowk with history of high conflict intensity...
June 19, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28623628/does-patient-preference-measurement-in-decision-aids-improve-decisional-conflict-a-randomized-trial-in-men-with-prostate-cancer
#12
Joseph D Shirk, Catherine M Crespi, Josemanuel D Saucedo, Sylvia Lambrechts, Ely Dahan, Robert Kaplan, Christopher Saigal
BACKGROUND: Shared decision making (SDM) has been advocated as an approach to medical decision making that can improve decisional quality. Decision aids are tools that facilitate SDM in the context of limited physician time; however, many decision aids do not incorporate preference measurement. OBJECTIVES: We aim to understand whether adding preference measurement to a standard patient educational intervention improves decisional quality and is feasible in a busy clinical setting...
June 16, 2017: Patient
https://www.readbyqxmd.com/read/28622980/how-do-hospital-respiratory-clinicians-perceive-antimicrobial-stewardship-ams-a-qualitative-study-highlighting-barriers-to-ams-in-respiratory-medicine
#13
J Broom, A Broom, E Kirby, A F Gibson, J J Post
BACKGROUND: Suboptimal antibiotic use in respiratory infections is widespread in hospital medicine and primary care. Antimicrobial stewardship (AMS) teams within hospitals, commonly led by infectious diseases physicians, are frequently charged with optimizing the use of respiratory antibiotics, but there is limited information on what drives antibiotic use in this area of clinical medicine, or on how AMS is perceived. AIM: To explore the perceptions of hospital respiratory clinicians on AMS in respiratory medicine...
May 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28620322/the-relationship-of-complex-post-traumatic-stress-disorder-and-post-traumatic-stress-disorder-in-a-culturally-distinct-conflict-affected-population-a-study-among-west-papuan-refugees-displaced-to-papua-new-guinea
#14
Derrick Silove, Alvin Kuowei Tay, Moses Kareth, Susan Rees
BACKGROUND: Controversy continues about the validity of the construct of complex post-traumatic stress disorder (C-PTSD). In particular, questions remain whether C-PTSD can be differentiated from post-traumatic stress disorder (PTSD) and, secondarily, other common mental disorders. The examination of these issues needs to be expanded to populations of diverse cultural backgrounds exposed to prolonged persecution. We undertake such an inquiry among a community sample of West Papuan refugees exposed to extensive persecution and trauma...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28612612/-molecular-aspects-of-thyroid-tumors-with-emphasis-on-microrna-and-their-clinical-implications
#15
M Ludvíková, I Kholová, D Kalfeřt
BACKGROUND: Central to neoplastic transformation and tumor progression is alteration of the signaling pathways that control cell proliferation and apoptosis. The key mechanisms for this neoplastic process are genetic changes (mutations of cancer-related genes) and recently identified epigenetic changes that involve DNA methylation, chromatin remodeling (which has a profound effect on the control of gene expression), and noncoding, regulatory RNA (notably, microRNA - miRNA). MiRNAs control expression of their target gene post-transcriptionally...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28612468/decision-making-processes-among-men-with-low-risk-prostate-cancer-a-survey-study
#16
Richard M Hoffman, Stephen K Van Den Eeden, Kimberly M Davis, Tania Lobo, George Luta, Jun Shan, David Aaronson, David F Penson, Amethyst D Leimpeter, Kathryn Taylor
OBJECTIVE: To characterize decision-making processes and outcomes among men expressing early treatment preferences for low-risk prostate cancer. METHODS: We conducted telephone surveys of men newly diagnosed with low-risk prostate cancer in 2012-14. We analyzed subject who had discussed prostate cancer treatment with a clinician and expressed a treatment preference. We asked about decision-making processes, including physician discussions, prostate-cancer knowledge, decision-making styles, treatment preference, and decisional conflict...
June 13, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28611675/cardiac-autonomic-responses-during-exercise-and-post-exercise-recovery-using-heart-rate-variability-and-systolic-time-intervals-a-review
#17
REVIEW
Scott Michael, Kenneth S Graham, Glen M Davis
Cardiac parasympathetic activity may be non-invasively investigated using heart rate variability (HRV), although HRV is not widely accepted to reflect sympathetic activity. Instead, cardiac sympathetic activity may be investigated using systolic time intervals (STI), such as the pre-ejection period. Although these autonomic indices are typically measured during rest, the "reactivity hypothesis" suggests that investigating responses to a stressor (e.g., exercise) may be a valuable monitoring approach in clinical and high-performance settings...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28611437/reproductive-isolation-through-experimental-manipulation-of-sexually-antagonistic-coevolution-in-drosophila-melanogaster
#18
Zeeshan Ali Syed, Martik Chatterjee, Manas Arun Samant, Nagaraj Guru Prasad
Promiscuity can drive the evolution of sexual conflict before and after mating occurs. Post mating, the male ejaculate can selfishly manipulate female physiology, leading to a chemical arms race between the sexes. Theory suggests that drift and sexually antagonistic coevolution can cause allopatric populations to evolve different chemical interactions between the sexes, thereby leading to postmating reproductive barriers and speciation. There is, however, little empirical evidence supporting this form of speciation...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610578/sub-national-assessment-of-aid-effectiveness-a-case-study-of-post-conflict-districts-in-uganda
#19
Freddie Ssengooba, Justine Namakula, Vincent Kawooya, Suzanne Fustukian
BACKGROUND: In post-conflict settings, many state and non-state actors interact at the sub-national levels in rebuilding health systems by providing funds, delivering vital interventions and building capacity of local governments to shoulder their roles. Aid relationships among actors at sub-national level represent a vital lever for health system development. This study was undertaken to assess the aid-effectiveness in post-conflict districts of northern Uganda. METHOD: This was a three district cross sectional study conducted from January to April 2013...
June 13, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28608852/risk-of-psychosis-in-refugees-a-literature-review
#20
REVIEW
J Dapunt, U Kluge, A Heinz
Conflicts and precarious living conditions resulted in the arrival of large numbers of refugees in Europe and especially in Germany. Evidence suggests that immigrant populations are at elevated risk of psychotic disorders. Considering the traumatic pre- and post-migratory adversities refugees may have encountered, people granted refugee status may even be more susceptible to psychosis than non-refugee migrants. The aim of this literature review is to summarise and interpret recent research on the incidence or prevalence of psychotic disorders in refugees, additionally focusing on the aspects of gender and Middle Eastern provenance...
June 13, 2017: Translational Psychiatry
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