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Biomedical optics

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https://www.readbyqxmd.com/read/27917407/microwave-heating-of-synthetic-skin-samples-for-potential-treatment-of-gout-using-the-metal-assisted-and-microwave-accelerated-decrystallization-technique
#1
Salih Toker, Zainab Boone-Kukoyi, Nishone Thompson, Hillary Ajifa, Travis Clement, Birol Ozturk, Kadir Aslan
Physical stability of synthetic skin samples during their exposure to microwave heating was investigated to demonstrate the use of the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique for potential biomedical applications. In this regard, optical microscopy and temperature measurements were employed for the qualitative and quantitative assessment of damage to synthetic skin samples during 20 s intermittent microwave heating using a monomode microwave source (at 8 GHz, 2-20 W) up to 120 s...
November 30, 2016: ACS Omega
https://www.readbyqxmd.com/read/27914328/synthesis-and-stability-of-ir-820-and-fitc-doped-silica-nanoparticles
#2
Atul V Thorat, Tandra Ghoshal, Lan Chen, Justin D Holmes, Michael A Morris
Fluorescent silica nanoparticles (NPs) have potential in biomedical applications as diagnostics and traceable drug delivery agents. In this study, we have synthesized fluorescent dye grafted silica NPs in two step process. First, a stable method to synthesize various sizes of silica NPs ranging from 20 to 52, 95, 210 and 410nm have been successfully demonstrated. Secondly, as-synthesized silica NPs are readily grafted with some fluorescent dyes like IR-820 and fluorescein isothiocyanate (FITC) dyes by simple impregnation method...
November 15, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27910863/compressive-sensing-with-optical-chaos
#3
D Rontani, D Choi, C-Y Chang, A Locquet, D S Citrin
Compressive sensing (CS) is a technique to sample a sparse signal below the Nyquist-Shannon limit, yet still enabling its reconstruction. As such, CS permits an extremely parsimonious way to store and transmit large and important classes of signals and images that would be far more data intensive should they be sampled following the prescription of the Nyquist-Shannon theorem. CS has found applications as diverse as seismology and biomedical imaging. In this work, we use actual optical signals generated from temporal intensity chaos from external-cavity semiconductor lasers (ECSL) to construct the sensing matrix that is employed to compress a sparse signal...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27907858/rapid-preparation-of-branched-and-degradable-aie-active-fluorescent-organic-nanoparticles-via-formation-of-dynamic-phenyl-borate-bond
#4
Zi Long, Meiying Liu, Liucheng Mao, Guangjian Zeng, Qing Wan, Dazhuang Xu, Fengjie Deng, Hongye Huang, Xiaoyong Zhang, Yen Wei
The fluorescent organic nanoparticles (FNPs) with aggregation-induced emission (AIE) feature have received increasing attention for their advanced optical properties. Although many efforts have been devoted to the fabrication and biomedical applications of AIE-active FNPs, the preparation of branched AIE-active FNPs with degradability through formation of dynamic bonds have rarely been reported. In this work, branched AIE-active FNPs were fabricated via dynamic linkage of hydrophobic hyperbranched and degradable Boltorn H40 (H40) with phenylboronic acid terminated AIE dye (PhB(OH)2) and mPEG (mPEG-B(OH)2), which relied on a facile one-pot strategy between phenylboronic acid and diol group of H40...
November 17, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27906396/gadolinium-oxysulfide-coated-gold-nanorods-with-improved-stability-and-dual-modal-magnetic-resonance-photoacoustic-imaging-contrast-enhancement-for-cancer-theranostics
#5
Tao Guo, Yan Lin, Zhi Li, Shan Chen, Guoming Huang, Huirong Lin, Jun Wang, Gang Liu, Huang-Hao Yang
Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of Gd2O2S around GNRs is reported to address these limitations of GNRs. After the coating of the Gd2O2S shell, the as-fabricated Gd2O2S coated GNRs (GNRs@Gd2O2S) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906261/impact-of-nonstationary-optical-illumination-on-image-reconstruction-in-optoacoustic-tomography
#6
Yang Lou, Kun Wang, Alexander A Oraevsky, Mark A Anastasio
Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to illuminate the tissue of interest and acoustic signals are produced via the photoacoustic effect. From these data, an estimate of the distribution of the absorbed optical energy density within the tissue is reconstructed, referred to as the object function. This quantity is defined, in part, by the distribution of light fluence within the tissue that is established by the laser source...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27896017/simple-approach-to-three-color-two-photon-microscopy-by-a-fiber-optic-wavelength-convertor
#7
Kuen-Che Li, Lynn L H Huang, Jhih-Hao Liang, Ming-Che Chan
A simple approach to multi-color two-photon microscopy of the red, green, and blue fluorescent indicators was reported based on an ultra-compact 1.03-μm femtosecond laser and a nonlinear fiber. Inside the nonlinear fiber, the 1.03-μm laser pulses were simultaneously blue-shifted to 0.6~0.8 μm and red-shifted to 1.2~1.4 μm region by the Cherenkov radiation and fiber Raman gain effects. The wavelength-shifted 0.6~0.8 μm and 1.2~1.4 μm radiations were co-propagated with the residual non-converted 1.03-μm pulses inside the same nonlinear fiber to form a fiber-output three-color femtosecond source...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27896012/long-range-and-wide-field-of-view-optical-coherence-tomography-for-in-vivo-3d-imaging-of-large-volume-object-based-on-akinetic-programmable-swept-source
#8
Shaozhen Song, Jingjiang Xu, Ruikang K Wang
Current optical coherence tomography (OCT) imaging suffers from short ranging distance and narrow imaging field of view (FOV). There is growing interest in searching for solutions to these limitations in order to expand further in vivo OCT applications. This paper describes a solution where we utilize an akinetic swept source for OCT implementation to enable ~10 cm ranging distance, associated with the use of a wide-angle camera lens in the sample arm to provide a FOV of ~20 x 20 cm(2). The akinetic swept source operates at 1300 nm central wavelength with a bandwidth of 100 nm...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27896008/experimental-results-of-full-scattering-profile-from-finger-tissue-like-phantom
#9
Idit Feder, Maciej Wróbel, Hamootal Duadi, Małgorzata Jędrzejewska-Szczerska, Dror Fixler
Human tissue is one of the most complex optical media since it is turbid and nonhomogeneous. We suggest a new optical method for sensing physiological tissue state, based on the collection of the ejected light at all exit angles, to receive the full scattering profile. We built a unique set-up for noninvasive encircled measurement. We use a laser, a photodetector and finger tissues-mimicking phantoms presenting different optical properties. Our method reveals an isobaric point, which is independent of the optical properties...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27890802/highly-water-absorbing-silk-yarn-with-interpenetrating-network-via-in-situ-polymerization
#10
Ka I Lee, Xiaowen Wang, Xia Guo, Ka-Fu Yung, Bin Fei
Silk was modified via in situ polymerization of two monomers acrylamide and sodium acrylate by swelling in an effective LiBr dissolution system. Swelling of natural silks in LiBr solutions of low concentration was clearly observed under optical microscope, and their conformational changes were revealed by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Dissolution tests and FTIR spectra of these modified silks suggested the presence of interpenetrating network of polyacrylamide and poly(sodium acrylate) in the silk yarns...
November 24, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27877861/fabrication-of-photoactive-heterostructures-based-on-quantum-dots-decorated-with-au-nanoparticles
#11
Elisabetta Fanizza, Carmine Urso, R Maria Iacobazzi, Nicoletta Depalo, Michela Corricelli, Annamaria Panniello, Angela Agostiano, Nunzio Denora, Valentino Laquintana, Marinella Striccoli, M Lucia Curri
Silica based multifunctional heterostructures, exhibiting near infrared (NIR) absorption (650-1200 nm) and luminescence in the visible region, represent innovative nanosystems useful for diagnostic or theranostic applications. Herein, colloidal synthetic procedures are applied to design a photoactive multifunctional nanosystem. Luminescent silica (SiO2) coated quantum dots (QDs) have been used as versatile nanoplatforms to assemble on their surface gold (Au) seeds, further grown into Au spackled structures...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877243/recent-advances-in-photoacoustic-imaging-for-deep-tissue-biomedical-applications
#12
REVIEW
Sheng Wang, Jing Lin, Tianfu Wang, Xiaoyuan Chen, Peng Huang
Photoacoustic imaging (PAI), a novel imaging modality based on photoacoustic effect, shows great promise in biomedical applications. By converting pulsed laser excitation into ultrasonic emission, PAI combines the advantages of optical imaging and ultrasound imaging, which benefits rich contrast, high resolution and deep tissue penetration. In this paper, we introduced recent advances of contrast agents, applications, and signal enhancement strategies for PAI. The PA contrast agents were categorized by their components, mainly including inorganic and organic PA contrast agents...
2016: Theranostics
https://www.readbyqxmd.com/read/27876601/bioapplications-of-graphene-constructed-functional-nanomaterials
#13
REVIEW
Arif Gulzar, Piaoping Yang, Fei He, Jiating Xu, Dan Yang, Liangge Xu, Mohammad Omar Jan
Graphene has distinctive mechanical, electronic, and optical properties, which researchers have applied to develop innovative electronic materials including transparent conductors and ultrafast transistors. Lately, the understanding of various chemical properties of graphene has expedited its application in high-performance devices that generate and store energy. Graphene is now increasing its terrain outside electronic and chemical applications toward biomedical areas such as precise bio sensing through graphene-quenched fluorescence, graphene-enhanced cell differentiation and growth, and graphene-assisted laser desorption/ionization for mass spectrometry...
November 19, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27874059/super-enhancement-of-1-54%C3%A2-%C3%AE-m-emission-from-erbium-codoped-with-oxygen-in-silicon-on-insulator
#14
M A Lourenço, M M Milošević, A Gorin, R M Gwilliam, K P Homewood
We report on the super enhancement of the 1.54 μm Er emission in erbium doped silicon-on-insulator when codoped with oxygen at a ratio of 1:1. This is attributed to a more favourable crystal field splitting in the substitutional tetrahedral site favoured for the singly coordinated case. The results on these carefully matched implant profiles show that optical response is highly determined by the amount and ratio of erbium and oxygen present in the sample and ratios of O:Er greater than unity are severely detrimental to the Er emission...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27874052/multifunctional-single-beam-acoustic-tweezer-for-non-invasive-cell-organism-manipulation-and-tissue-imaging
#15
Kwok Ho Lam, Ying Li, Yang Li, Hae Gyun Lim, Qifa Zhou, Koping Kirk Shung
Non-contact precise manipulation of single microparticles, cells, and organisms has attracted considerable interest in biophysics and biomedical engineering. Similar to optical tweezers, acoustic tweezers have been proposed to be capable of manipulating microparticles and even cells. Although there have been concerted efforts to develop tools for non-contact manipulation, no alternative to complex, unifunctional tweezer has yet been found. Here we report a simple, low-cost, multifunctional single beam acoustic tweezer (SBAT) that is capable of manipulating an individual micrometer scale non-spherical cell at Rayleigh regime and even a single millimeter scale organism at Mie regime, and imaging tissue as well...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873448/multibuilding-block-janus-synthesized-by-seed-mediated-self-assembly-for-enhanced-photothermal-effects-and-colored-brownian-motion-in-an-optical-trap
#16
Kanokwan Sansanaphongpricha, Michael C DeSantis, Hongwei Chen, Wei Cheng, Kai Sun, Bo Wen, Duxin Sun
The asymmetrical features and unique properties of multibuilding block Janus nanostructures (JNSs) provide superior functions for biomedical applications. However, their production process is very challenging. This problem has hampered the progress of JNS research and the exploration of their applications. In this study, an asymmetrical multibuilding block gold/iron oxide JNS has been generated to enhance photothermal effects and display colored Brownian motion in an optical trap. JNS is formed by seed-mediated self-assembly of nanoparticle-loaded thermocleavable micelles, where the hydrophobic backbones of the polymer are disrupted at high temperatures, resulting in secondary self-assembly and structural rearrangement...
November 22, 2016: Small
https://www.readbyqxmd.com/read/27866899/potential-of-compact-compton-sources-in-the-medical-field
#17
Marie Jacquet
The exceptional improvement of high power lasers and optical cavity finesses in the last fifteen years allows today the development of X-ray sources based on inverse Compton scattering. These compact sources will provide high intensity beams, with a tunable energy in the range 20-100keV, that can be used in several application including material sciences, structural biology, cultural heritage research and preservation and medical or biomedical preclinical and clinical research. The access to these devices will be easier...
November 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27866616/in-vivo-synthesis-of-europium-selenide-nanoparticles-and-related-cytotoxicity-evaluation-of-human-cells
#18
Eun Bee Kim, Ji Min Seo, Gi Wook Kim, Sang Yup Lee, Tae Jung Park
Nanotechnology strives to combine new materials for development of noble nanoparticles. As the nanoparticles exhibit unique optical, electronic, and magnetic properties depending on their composition, developing safe, cost-effective and environmentally friendly technologies for the synthesis have become an important issue. In this study, in vivo synthesis of europium selenide (EuSe) nanoparticles was performed using recombinant Escherichia coli cells expressing heavy-metal binding proteins, phytochelatin synthase and metallothionein...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27858357/surface-plasmon-resonance-analysis-of-heparin-binding-angiogenic-growth-factors
#19
Marco Rusnati, Antonella Bugatti
Surface plasmon resonance (SPR) is an optical technique to evaluate biomolecular interactions. Briefly, SPR measures the capacity of two molecules to bind each other by detecting reflected light from a prism-gold film interface. One of the two putative interactants (called ligand) is chemically immobilized onto the gold film. When the sensor is exposed to a sample containing the second interactant (called analyte), its binding to the immobilized ligand causes a change of the refractive index of the material above the gold surface that is monitored as a real-time graph of the response units against time, producing a real-time graph called sensorgram...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27835789/a-comparative-performance-analysis-of-multispectral-and-rgb-imaging-on-her2-status-evaluation-for-the-prediction-of-breast-cancer-prognosis
#20
Wenlou Liu, Linwei Wang, Jiuyang Liu, Jingping Yuan, Jiamei Chen, Han Wu, Qingming Xiang, Guifang Yang, Yan Li
Despite the extensive application of multispectral imaging (MSI) in biomedical multidisciplinary researches, there is a paucity of data available regarding the implication of MSI in tumor prognosis prediction. We compared the behaviors of multispectral (MS) and conventional red-green-blue (RGB) images on assessment of human epidermal growth factor receptor 2 (HER2) immunohistochemistry to explore their impact on outcome in patients with invasive breast cancer (BC). Tissue microarrays containing 240 BC patients were introduced to compare the performance of MS and RGB imaging methods on the quantitative assessment of HER2 status and the prognostic value of 5-year disease-free survival (5-DFS)...
November 8, 2016: Translational Oncology
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