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Biomedical optics

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https://www.readbyqxmd.com/read/28544392/growth-process-and-anti-cancer-properties-of-gold-nanorods
#1
Junyan Zhang, Mian Wang, Thomas J Webster
Gold nanoparticles have been of great interest due to their unique optical properties, facile synthesis and conjugation. Among various shapes of gold nanoparticles, gold nanorods have been widely studied. They can be conjugated with different molecules for biomedical applications, such as tumor imaging and therapy. However, few researchers have studied the anti-tumor properties of bare gold nanorods. In this study, unfunctionalized gold nanorods were synthesized and tested on breast tumor cells. Results showed that the aspect ratio of gold nanorods could be easily influenced by both reaction time and the amount of silver nitrate in the growth solution...
May 24, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28540373/in-vitro-cellular-behaviors-and-toxicity-assays-of-small-sized-fluorescent-silicon-nanoparticles
#2
Zhaohui Cao, Fei Peng, Zhilin Hu, Binbin Chu, Yiling Zhong, Yuanyuan Su, Sudan He, Yao He
Extensive investigations have been carried out for evaluating the toxicology of various nanomaterials (e.g., carbon- and metal-based nanomaterials), which offer invaluable information for assessing the feasibility of nanomaterial-based wide-ranging applications. In recent years, sufficient efforts have been made to develop fluorescent small-sized silicon nanoparticles (SiNPs) as a novel optical material simultaneously featuring strong fluorescence and ultrahigh photostability, providing high promise for a myriad of biological, biomedical and electronic applications...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28535341/fully-stretchable-optoelectronic-sensors-based-on-colloidal-quantum-dots-for-sensing-photoplethysmographic-signals
#3
Tae-Ho Kim, Chang-Seok Lee, Sangwon Kim, Jaehyun Hur, Sangmin Lee, Keun Wook Shin, Young-Zoon Yoon, Moon Kee Choi, Jiwoong Yang, Dae-Hyeong Kim, Taeghwan Hyeon, Seongjun Park, Sungwoo Hwang
Flexible and stretchable optoelectronic devices can be potentially applied in displays, biosensors, biomedicine, robotics, and energy generation. The use of nanomaterials with superior optical properties such as quantum dots (QDs) is important in the realization of wearable displays and biomedical devices, but specific structural design as well as selection of materials should preferentially accompany this technology to realize stretchable forms of these devices. Here, we report stretchable optoelectronic sensors manufactured using colloidal QDs and integrated with elastomeric substrates, whose optoelectronic properties are stable under various deformations...
May 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28534926/asymmetric-bead-aggregation-for-microfluidic-immunodetection
#4
Sunggu Kim, Sanghoon Han, Junghoon Lee
We report an asymmetric immunoaggregation assay for rapid, label-free, and sub-picomolar protein detection. Asymmetric immunoaggregated beads (AIBs) are formed when binding occurs between 1 μm magnetic (MG) and 2.8 μm polystyrene (PS) beads coated with specific antibodies for a target antigen. Detection of such aggregation is achieved by optical monitoring of AIBs in a flow under an external magnetic field. AIBs are attracted to the upper surface of the microchannel by a magnetic field and made to slide along the surface by a flow drag force...
May 23, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28533523/characterization-of-two-distant-double-slits-by-chaotic-light-second-order-interference
#5
Milena D'Angelo, Aldo Mazzilli, Francesco V Pepe, Augusto Garuccio, Vincenzo Tamma
We present the experimental characterization of two distant double-slit masks illuminated by chaotic light, in the absence of first-order imaging and interference. The scheme exploits second-order interference of light propagating through two indistinguishable pairs of disjoint optical paths passing through the masks of interest. The proposed technique leads to a deeper understanding of biphoton interference and coherence, and opens the way to the development of novel schemes for retrieving information on the relative position and the spatial structure of distant objects, which is of interest in remote sensing, biomedical imaging, as well as monitoring of laser ablation, when first-order imaging and interference are not feasible...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533451/animal-coloration-research-why-it-matters
#6
Tim Caro, Mary Caswell Stoddard, Devi Stuart-Fox
While basic research on animal coloration is the theme of this special edition, here we highlight its applied significance for industry, innovation and society. Both the nanophotonic structures producing stunning optical effects and the colour perception mechanisms in animals are extremely diverse, having been honed over millions of years of evolution for many different purposes. Consequently, there is a wealth of opportunity for biomimetic and bioinspired applications of animal coloration research, spanning colour production, perception and function...
July 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28532118/facile-synthesis-of-polymeric-fluorescent-organic-nanoparticles-based-on-the-self-polymerization-of-dopamine-for-biological-imaging
#7
Yingge Shi, Ruming Jiang, Meiying Liu, Lihua Fu, Guangjian Zeng, Qing Wan, Liucheng Mao, Fengjie Deng, Xiaoyong Zhang, Yen Wei
Polymeric fluorescent organic nanoparticles (polymer-FONs) have raised considerable research attention for biomedical applications owing to their advantages as compared with fluorescent inorganic nanoparticles and small organic molecules. In this study, we presented an efficient, facile and environment-friendly strategy to produce polymer-FONs, which relied on the self-polymerization of dopamine and polyethyleneimine (PEI) in rather mild conditions. To obtain the final polymer-FONs, aldehyde group-containing copolymers (named as poly(UA-co-PEGMA)) were synthesized by reversible addition-fragmentation chain-transfer polymerization using polyethylene glycol methyl ether methacrylate (PEGMA) and 1-undecen-10-al (UA) as monomers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28524252/in-vivo-noninvasive-analysis-of-graphene-nanomaterial-pharmacokinetics-using-photoacoustic-flow-cytometry
#8
Dmitry A Nedosekin, Jacqueline Nolan, Chengzhong Cai, Shawn E Bourdo, Zeid Nima, Alexandru S Biris, Vladimir P Zharov
Graphene-based nanomaterials (GBNs) are quickly revolutionizing modern electronics, energy generation and storage, clothing and biomedical devices. Due to GBN's variety of physical and chemical parameters that define their toxicity and their aggregation in suspension, interpreting its toxicology without accurate information on graphene's distribution and behavior in live organisms is challenging. In this work, we present a laser-based optical detection methodology for noninvasive detection and pharmacokinetics analysis of GBNs directly in blood flow in mice using in vivo photoacoustic (PA) flow cytometry (PAFC)...
May 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28516773/amphiphilic-bodipy-hydroporphyrin-energy-transfer-arrays-with-broadly-tunable-absorption-and-deep-red-near-infrared-emission-in-aqueous-micelles
#9
Adam Meares, Andrius Satraitis, Joshua Akhigbe, Nithya Santhanam, Subramani Swaminathan, Melanie Ehudin, Marcin Ptaszek
BODIPY-hydroporphyrin energy transfer arrays allow for development of family of fluorophores featuring a common excitation band at 500 nm, tunable excitation band in deep red/near-infrared window, and tunable emission. Their biomedical applications are contingent upon retaining their optical properties in aqueous environment. Amphiphilic arrays containing PEG-substituted BODIPY and chlorins or bacteriochlorins were prepared and their optical and fluorescence properties were determined in organic solvents and aqueous surfactants...
May 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28516571/fsoca-induced-switchable-footpad-skin-optical-clearing-window-for-blood-flow-and-cell-imaging-in%C3%A2-vivo
#10
Rui Shi, Wei Feng, Chao Zhang, Zhihong Zhang, Dan Zhu
The mouse footpad for its feature of hairlessness provides an available window for imaging vascular and cellular structure and function in vivo. Unfortunately, the strong scattering of its skin limits the penetration of light and reduces the imaging contrast and depth. Herein, an innovative footpad skin optical clearing agent (FSOCA) was developed to make the footpad skin transparent quickly by topical application. The results demonstrate that FSOCA treatment not only allowed the cutaneous blood vessels and blood flow distribution to be monitored by laser speckle contrast imaging technique with higher contrast, but also permitted the fluorescent cells to be imaged by laser scanning confocal microscopy with higher fluorescence signal intensity and larger imaging depth...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28513721/programmable-micrometer-sized-motor-array-based-on-live-cells
#11
Shuangxi Xie, Xiaodong Wang, Niandong Jiao, Steve Tung, Lianqing Liu
Trapping and transporting microorganisms with intrinsic motility are important tasks for biological, physical, and biomedical applications. However, fast swimming speed makes the manipulation of these organisms an inherently challenging task. In this study, we demonstrated that an optoelectrical technique, namely, optically induced dielectrophoresis (ODEP), could effectively trap and manipulate Chlamydomonas reinhardtii (C. reinhardtii) cells swimming at velocities faster than 100 μm s(-1). Furthermore, live C...
May 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28507699/polylysine-grafted-au144-nanoclusters-birth-and-growth-of-a-healthy-surface-plasmon-resonance-like-band
#12
Ivan Guryanov, Federico Polo, Evgeniy V Ubyvovk, Evgenia Korzhikova-Vlakh, Tatiana Tennikova, Armin T Rad, Mu-Ping Nieh, Flavio Maran
Poly(amino acid)-coated gold nanoparticles hold promise in biomedical applications, particularly because they combine the unique physicochemical properties of the gold core, excellent biocompatibility, and easy functionalization of the poly(amino acid)-capping shell. Here we report a novel method for the preparation of robust hybrid core-shell nanosystems consisting of a Au144 cluster and a densely grafted polylysine layer. Linear polylysine chains were grown by direct N-carboxyanhydride (NCA) polymerization onto ligands capping the gold nanocluster...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28504415/highly-luminescent-folate-functionalized-au22-nanoclusters-for-bioimaging
#13
Kyunglim Pyo, Nguyen Hoang Ly, Sook Young Yoon, Yiming Shen, Seon Young Choi, So Yeong Lee, Sang-Woo Joo, Dongil Lee
Gold nanoclusters are emerging as new materials for biomedical applications because of promises offered by their ultrasmall size and excellent biocompatibility. Here, the synthesis and optical and biological characterizations of a highly luminescent folate-functionalized Au22 cluster (Au22 -FA) are reported. The Au22 -FA clusters are synthesized by functionalizing the surface of Au22 (SG)18 clusters, where SG is glutathione, with benzyl chloroformate and folate. The functionalized clusters are highly water-soluble and exhibit remarkably bright luminescence with a quantum yield of 42%, significantly higher than any other water-soluble gold clusters protected with thiolate ligands...
May 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28497974/carbon-nanotube-and-semiconductor-nanorods-hybrids-preparation-characterization-and-evaluation-of-photocurrent-generation
#14
Jugun Prakash Chinta, Nir Waiskopf, Gur Lubin, David Rand, Yael Hanein, Uri Banin, Shlomo Yitzchaik
Carbon nanotubes (CNTs) and semiconductor nanocrystals (SCNCs) are known to be interesting donor-acceptor partners due to their unique optical and electronic properties. These exciting features have led to the development of novel composites based on these two nanomaterials and to their characterization for use in various applications, such as components in sensors, transistors, solar cells and biomedical devices. Two approaches based on covalent and noncovalent methods have been suggested for coupling the SCNCs to CNTs...
May 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28494152/low-temperature-synthesis-of-carbon-rich-nanoparticles-with-clickable-surface-for-functionalization
#15
Audrey Picard-Lafond, Jean-Francois Morin
Carbon nanoparticles (CNPs) are promising materials for optoelectronic and biomedical applications thanks to their optical properties, low production cost, and superior biocompatibility compared to traditional semi-conductor quantum dots. The countless synthetic methods reported allow a library of diverse CNPs structures and optical properties, guiding their subsequent applications. However, the current drawbacks lie mainly within these synthetic processes, as many of them require harsh conditions preventing control over morphology and often generating chemically inert nanoparticles...
May 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28482567/polymerizable-aggregation-induced-emission-dye-for-preparation-of-cross-linkable-fluorescent-nanoprobes-with-ultra-low-critical-micelle-concentrations
#16
Long Huang, Meiying Liu, Liucheng Mao, Xiqi Zhang, Dazhuang Xu, Qing Wan, Qiang Huang, Yingge Shi, Fengjie Deng, Xiaoyong Zhang, Yen Wei
In recent years, aggregation-induced emission (AIE) dyes based fluorescent organic nanoparticles (FONs) have achieved significant progress in various biomedical applications. In this work, we developed a covalent strategy to prepare biocompatible AIE-active dyes based cross-linked copolymers (MPC-POSS-PhE) via controllable reversible addition fragmentation chain transfer (RAFT) polymerization using zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC), polymerizable AIE dye (named as PhE) and 8-vinyl polyoctahedral silsesquioxanes (POSS) as monomers...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28477379/tolyporphin-an-unusual-green-chlorin-like-dioxobacteriochlorin
#17
Christian Brückner
The tolyporphins, a family of green tetrapyrrolic pigments isolated from a cyanobacterium-microbial ecological unit, possess unique carbohydrate-derivatized dioxobacteriochlorin frameworks. A brief overview over the history, synthesis, chemistry, and biological properties of the tolyporphins form the backdrop for highlighting the contribution by Hood et al. [Hood, D., D. M. Niedzwiedzki, R. Zhang, Y. Zhang, J. Dai, E. S. Miller, D. F. Bocian, P. G. Williams, J. S. Lindsey and D. Holten (2017) Photochem. Photobiol...
May 6, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28471202/-use-of-porous-hydrogel-as-a-3d-scaffold-for-the-growth-of-leukemic-b-lymphocytes
#18
R Studená, D Horák, J Baloun, Z Plichta, Š Pospíšilová
BACKGROUND: Primary human B cells chronic lymphocytic leukemia undergoes apoptosis, from which they can be rescued by contact with stromal cells or by the addition of specific soluble factor, when cultured in vitro. For research purposes of the behavior of CLL cells we created 3D in vitro model in which we simulated appropriate microenvironment for CLL cells to allow study the mechanism of survival of these cells in long-term cultivation. MATERIAL AND METHODS: Our aim was the scaffold structure to be geometrically similar to the 3D morphology of supporting bone marrow tissue in a trabecular bone; the 3D scaffold was also designed to conform to biocompatibility, sufficiently large surface area for cell attachment, high porosity for cell migration, proliferation and transport of nutrients...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28466913/recent-progress-in-biomedical-applications-of-persistent-luminescence-nanoparticles
#19
REVIEW
Jie Wang, Qinqin Ma, Yingqian Wang, Haijing Shen, Quan Yuan
Persistent luminescence nanoparticles (PLNPs) are an emerging group of promising luminescent materials that can remain luminescent after the excitation ceases. In the past decade, PLNPs with intriguing optical properties have been developed and their applications in biomedicine have been widely studied. Due to the ultra-long decay time of persistent luminescence, autofluorescence interference in biosensing and bioimaging can be efficiently eliminated. Moreover, PLNPs can remain luminescent for hours, making them valuable in bio-tracing...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28464464/mueller-polarimetric-imaging-for-surgical-and-diagnostic-applications-a-review
#20
REVIEW
Ji Qi, Daniel S Elson
Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities...
May 2, 2017: Journal of Biophotonics
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