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Biomedical optics

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https://www.readbyqxmd.com/read/28454166/fabrication-of-multipoint-side-firing-optical-fiber-by-laser-micro-ablation
#1
Hoang Nguyen, Md Masud Parvez Arnob, Aaron T Becker, John C Wolfe, Matthew K Hogan, Philip J Horner, Wei-Chuan Shih
A multipoint, side-firing design enables an optical fiber to output light at multiple desired locations along the fiber body. This provides advantages over traditional end-to-end fibers, especially in applications requiring fiber bundles such as brain stimulation or remote sensing. This Letter demonstrates that continuous wave (CW) laser micro-ablation can controllably create conical-shaped cavities, or side windows, for outputting light. The dimensions of these cavities determine the amount of firing light and their firing angle...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28445606/structural-and-biological-properties-of-thermosensitive-chitosan-graphene-hybrid-hydrogels-for-sustained-drug-delivery-applications
#2
Leyla Saeednia, Li Yao, Marcus Berndt, Kim Cluff, Ramazan Asmatulu
Chitosan has the ability to make injectable thermosensitive hydrogels which has been highly investigated for drug delivery applications. The addition of nanoparticles is one way to increase the mechanical strength of thermosensitive chitosan hydrogel and subsequently and control the burst release of drug. Graphene nanoparticles have shown unique mechanical, optical and electrical properties which can be exploited for biomedical applications, especially in drug delivery. This study, have focused on the mechanical properties of a thermosensitive and injectable hybrid chitosan hydrogel incorporated with graphene nanoparticles...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28440618/design-of-antibacterial-polyethersulfone-membranes-via-covalently-attaching-hydrogel-thin-layers-loaded-with-ag-nanoparticles
#3
Min He, Qian Wang, Rui Wang, Yi Xie, Weifeng Zhao, Changsheng Zhao
In order to inhibit the bacteria attachment and the subsequent formation of bio-films on polyethersulfone (PES) membranes, poly(sulfobetaine methacrylate) (PSBMA)/poly(sodium acrylate) (PAANa) antibacterial hydrogel thin layers were covalently attached onto the membranes, followed by loading Ag nanoparticles. In our strategy, double bonds were firstly introduced onto PES membrane surfaces to provide anchoring sites, and then the hydrogel layers were synthesized on the membrane surfaces via UV light initiated cross-linking copolymerization...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28439980/nanophotonic-trapping-precise-manipulation-and-measurement-of-biomolecular-arrays
#4
REVIEW
James E Baker, Ryan P Badman, Michelle D Wang
Optical trapping is a powerful and widely used laboratory technique in the biological and materials sciences that enables rapid manipulation and measurement at the nanometer scale. However, expanding the analytical throughput of this technique beyond the serial capabilities of established single-trap microscope-based optical tweezers remains a current goal in the field. In recent years, advances in nanotechnology have been leveraged to create innovative optical trapping methods that increase the number of available optical traps and permit parallel manipulation and measurement of arrays of optically trapped targets...
April 24, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28438041/design-of-multifunctional-liposome-quantum-dot-hybrid-nanocarriers-and-their-biomedical-application
#5
Wenjing Qu, Wenbao Zuo, Na Li, Yanhui Hou, Zhihua Song, Guojing Gou, Jianhong Yang
Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have rich surface chemistry and unique optical properties that make them useful as probes or carriers for molecular diagnostics and therapeutics. However, their potential toxicity and instability in biological environments have puzzled scientific researchers. Much research effort has been devoted to encapsulation of QDs with liposomal hybrids to make them versatile nanocarriers for simultaneous therapeutics and diagnostics ("theranostics") and considerable progress has been made over recent years...
April 25, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28438004/autofocusing-airy-beams-generated-by-all-dielectric-metasurface-for-visible-light
#6
Qingbin Fan, Daopeng Wang, Pengcheng Huo, Zijie Zhang, Yuzhang Liang, Ting Xu
Conventional method to generate autofocusing Airy (AFA) beam involves the optical Fourier transform (FT) system, which has a fairly long working distance due to the focal length of FT lens, presence of spatial light modulator (SLM) and auxiliary total reflection mirrors. Here, we propose an extremely compact design to generate high-efficiency AFA beam at visible frequency by using metasurface which is composed of a single layer array of amorphous titanium dioxide (TiO<sub>2</sub>) elliptical nanofins sitting on the fused-silica substrate...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437081/silicon-induced-uv-transparency-in-phosphate-glasses-and-its-application-to-the-enhancement-of-the-uv-type-b-emission-of-gd-3
#7
José A Jiménez
The silicon route to improve the ultraviolet (UV) transparency in phosphate glasses is investigated, and further exploited to enhance the UV type B (280-320 nm) emission of gadolinium(III) relevant for biomedical applications. The glasses were synthesized with a barium-phosphate composition by melt-quenching in ambient atmosphere, and the optical properties investigated by optical absorption and photoluminescence (PL) spectroscopy including emission decay kinetics. An improvement in the UV transparency was gradually developed for the glasses melted merely with increasing amounts of Si powder...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436509/covering-the-optical-spectrum-through-collective-rare-earth-doping-of-nagdf4-nanoparticles-806-and-980-nm-excitation-routes
#8
A Skripka, R Marin, A Benayas, P Canton, E Hemmer, F Vetrone
Today, at the frontier of biomedical research, the need has been clearly established for integrating disease detection and therapeutic function in one single theranostic system. Light-emitting nanoparticles are being intensively investigated to fulfil this demand, by continuously developing nanoparticle systems simultaneously emitting in both the UV/visible (light-triggered release and activation of drugs) and the near-infrared (imaging and tracking) spectral regions. In this work, rare-earth (RE) doped nanoparticles (RENPs) were synthesized via a thermal decomposition process and spectroscopically investigated as potential candidates as all-in-one optical imaging, diagnostic and therapeutic agents...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28430235/fiber-bragg-grating-interrogation-using-wavelength-modulated-tunable-distributed-feedback-lasers-and-a-fiber-optic-mach-zehnder-interferometer
#9
Anirban Roy, Arup Lal Chakraborty, Chandan Kumar Jha
This paper demonstrates a technique of high-resolution interrogation of two fiber Bragg gratings (FBGs) with flat-topped reflection spectra centered on 1649.55 nm and 1530.182 nm with narrow line width tunable semiconductor lasers emitting at 1651.93 nm and 1531.52 nm, respectively. The spectral shift of the reflection spectrum in response to temperature and strain is accurately measured with a fiber-optic Mach-Zehnder interferometer that has a free spectral range of 0.0523 GHz and a broadband photodetector...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28425537/using-fluorescently-labeled-magnetic-nanocomposites-as-a-dual-contrast-agent-for-optical-and-magnetic-resonance-imaging
#10
Taofeng Zhu, Xiuqin Ma, Ruhua Chen, Zhijun Ge, Jun Xu, Xiaoke Shen, Lei Jia, Tao Zhou, Yifeng Luo, Tieliang Ma
Dual-modality imaging probes synergistically combine magnetic resonance (MR) and fluorescence into a single nanocomposite. This promising technique affords a new level of flexibility for molecular imaging uses in biomedical research. In this study, we report a new strategy for the synthesis of a novel attapulgite nanorod-based atta@Fe3O4@[Ru(bpy)2(fmp)]Cl2 nanocomposite (atta@Fe3O4@Ru NC). Our synthesized NC has both photoluminescent and magnetic properties, bright fluorescence, as well as significant magnetic resonance...
April 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28415471/synthesis-and-characterization-of-ti-27-5nb-alloy-made-by-clad%C3%A2-additive-manufacturing-process-for-biomedical-applications
#11
M Fischer, P Laheurte, P Acquier, D Joguet, L Peltier, T Petithory, K Anselme, P Mille
Biocompatible beta-titanium alloys such as Ti-27.5(at.%)Nb are good candidates for implantology and arthroplasty applications as their particular mechanical properties, including low Young's modulus, could significantly reduce the stress-shielding phenomenon usually occurring after surgery. The CLAD® process is a powder blown additive manufacturing process that allows the manufacture of patient specific (i.e. custom) implants. Thus, the use of Ti-27.5(at.%)Nb alloy formed by CLAD® process for biomedical applications as a mean to increase cytocompatibility and mechanical biocompatibility was investigated in this study...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412813/singlet-oxygen-detection-on-a-nanostructured-porous-silicon-thin-film-via-photonic-luminescence-enhancements
#12
S N Aisyiyah Jenie, Sally E Plush, Nicolas H Voelcker
Because reactive oxygen species are involved in a range of pathologies, developing analytical tools for this group of molecules opens new vistas for biomedical diagnostics. Herein, we fabricate a porous silicon microcavity (pSiMC) functionalized with luminescent singlet oxygen ((1)O2) probe EuA ((Eu(III)-2,2',2″-(10-(2-((4-(2-((4-(2-((anthracen-9-ylmethyl)amino)ethyl)-1H-1,2,3-triazol-1-yl)amino)-2-oxoethyl)-2-oxo-1,2-dihydroquinolin-7-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid) as proof of concept of an optical sensor for reactive oxygen species...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28401627/development-of-semiconducting-polymer-nanoparticles-for-photoacoustic-imaging
#13
REVIEW
Dong Cui, Chen Xie, Kanyi Pu
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state-of-the-art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration...
April 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28401218/dual-po2-pco2-fibre-optic-sensing-film
#14
John J Davenport, Michelle Hickey, Justin P Phillips, Panayiotis A Kyriacou
A fibre optic multi-sensor has been developed for biomedical sensing applications using a tip coating solution sensitive to both oxygen and carbon dioxide. An oxygen sensitive phosphorescence quenching complex based on platinum octaethylporphyrin (PtOEP) was combined with a carbon dioxide sensitive phosphorescence compound based on 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS). When excited by blue light (470 nm), the resultant coating had two fluorescent peaks at 515 nm (green) and 645 nm (red) which responded to partial pressure of CO2 and O2 respectively...
April 12, 2017: Analyst
https://www.readbyqxmd.com/read/28394585/compound-copper-chalcogenide-nanocrystals
#15
Claudia Coughlan, Maria Ibáñez, Oleksandr Dobrozhan, Ajay Singh, Andreu Cabot, Kevin M Ryan
This review captures the synthesis, assembly, properties, and applications of copper chalcogenide NCs, which have achieved significant research interest in the last decade due to their compositional and structural versatility. The outstanding functional properties of these materials stems from the relationship between their band structure and defect concentration, including charge carrier concentration and electronic conductivity character, which consequently affects their optoelectronic, optical, and plasmonic properties...
April 10, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28390838/super-resolution-microscopy-approaches-to-nuclear-nanostructure-imaging
#16
Christoph Cremer, Aleksander Szczurek, Florian Schock, Amine Gourram, Udo Birk
The human genome has been decoded, but we are still far from understanding the regulation of all gene activities. A largely unexplained role in these regulatory mechanisms is played by the spatial organization of the genome in the cell nucleus which has far-reaching functional consequences for gene regulation. Until recently, it appeared to be impossible to study this problem on the nanoscale by light microscopy. However, novel developments in optical imaging technology have radically surpassed the limited resolution of conventional far-field fluorescence microscopy (ca...
April 5, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28389668/photoacoustic-imaging-reveals-hidden-underdrawings-in-paintings
#17
George J Tserevelakis, Ilianna Vrouvaki, Panagiotis Siozos, Krystallia Melessanaki, Kostas Hatzigiannakis, Costas Fotakis, Giannis Zacharakis
A novel, non-invasive, imaging methodology, based on the photoacoustic effect, is introduced in the context of artwork diagnostics with emphasis on the uncovering of hidden features such as underdrawings or original sketch lines in paintings. Photoacoustic microscopy, a rapidly growing imaging method widely employed in biomedical research, exploits the ultrasonic acoustic waves, generated by light from a pulsed or intensity modulated source interacting with a medium, to map the spatial distribution of absorbing components...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28387734/cytotoxicity-of-zno-nanowire-arrays-on-excitable-cells
#18
Yongchen Wang, Yu Wu, Farhan Quadri, Jordan D Prox, Liang Guo
Zinc oxide (ZnO) nanowires have been widely studied for their applications in electronics, optics, and catalysts. Their semiconducting, piezoelectric, fluorescent, and antibacterial properties have also attracted broad interest in their biomedical applications. Thus, it is imperative to evaluate the biosafety of ZnO nanowires and their biological effects. In this study, the cellular level biological effects of ZnO nanowire arrays are specifically tested on three types of excitable cells, including NG108-15 neuronal cell line, HL-1 cardiac muscle cell line, and neonatal rat cardiomyocytes...
April 7, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28387409/a-giant-chiroptical-effect-caused-by-the-electric-quadrupole
#19
Tong Wu, Weixuan Zhang, Rongyao Wang, Xiangdong Zhang
Recently, there has been great interest in studying ultrasensitive detection and characterization of biomolecules using plasmonic particles, because they are of considerable importance in biomedical science and pharmaceutics. So far, all the theories on plasmon-induced circular dichroism (CD) have been based on the dipole approximation; the electric quadrupolar contribution is generally considered to be relatively small and neglected. Here we demonstrate that the electric quadrupolar contribution not only cannot be ignored, but it also plays a key role in many cases...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28384406/synthetic-engineering-of-spider-silk-fiber-as-implantable-optical-waveguides-for-low-loss-light-guiding
#20
Xin Qiao, Zhigang Qian, Junjie Li, Hongji Sun, Yao Han, Xiaoxia Xia, Jin Zhou, Chunlan Wang, Yan Wang, Changyong Wang
A variety of devices used for biomedical engineering have been fabricated using protein polymer because of their excellent properties, such as strength, toughness, biocompatibility, and biodegradability. In this study, we fabricated an optical waveguide using genetically engineered spider silk protein. This method has two significant advantages: (1) recombinant spider silk optical waveguide exhibits excellent optical and biological properties and (2) biosynthesis of spider silk protein can overcome the limitation to the research on spider silk optical waveguide due to the low yield of natural spider silk...
April 20, 2017: ACS Applied Materials & Interfaces
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