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Biomedical optics

Atul S Somkuwar, Bhargab Das, R V Vinu, YongKeun Park, Rakesh Kumar Singh
Optical imaging through complex scattering media is one of the major technical challenges with important applications in many research fields, ranging from biomedical imaging to astronomical telescopy to spatially multiplexed optical communications. Various approaches for imaging through a turbid layer have been recently proposed that exploit the advantage of object information encoded in correlations of the random optical fields. Here we propose and experimentally demonstrate an alternative approach for single-shot imaging of objects hidden behind an opaque scattering layer...
August 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Yingge Shi, Dazhuang Xu, Meiying Liu, Lihua Fu, Qing Wan, Liucheng Mao, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescent organic nanoparticles (FONs) have been regarded as the promising candidates for biomedical applications owing to their well adjustment of chemical structure and optical properties and good biological properties. However, the preparation of FONs from the natural derived polymers has been rarely reported thus far. In current work, we reported a novel strategy for preparation of FONs based on the self-polymerization of starch-dopamine conjugates and polyethyleneimine in rather mild experimental conditions, including air atmosphere, aqueous solution, absent catalysts and at room temperature...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Tingting Yu, Yisong Qi, Hui Gong, Qingming Luo, Dan Zhu
Three-dimensional reconstruction of tissue structures is essential for biomedical researches. The development of light microscopies and various fluorescent labeling techniques provides powerful tools for this motivation. However, optical imaging depth suffers from strong light scattering due to inherent heterogeneity of biological tissues. The tissue optical clearing technology provides a distinct solution and permits us to image large volume with high resolution. Up to date, various clearing methods have been developed...
October 12, 2017: Journal of Biophotonics
Sreeja Sarasamma, Muhammed Muhsin Varikkodan, Sung-Tzu Liang, Yen-Chang Lin, Wen-Pin Wang, Chung-Der Hsiao
The zebrafish (Danio rerio) is a versatile model organism that has been used in biomedical research for several decades to study a wide range of biological phenomena. There are many technical advantages of using zebrafish over other vertebrate models. They are readily available, hardy, easy, and inexpensive to maintain in the laboratory, have a short life cycle, and have excellent fecundity. Due to its optical clarity and reproducible capabilities, it has become one of the predominant models of human genetic diseases...
October 12, 2017: Zebrafish
Cesar Elosua, Francisco Javier Arregui, Ignacio Del Villar, Carlos Ruiz-Zamarreño, Jesus M Corres, Candido Bariain, Javier Goicoechea, Miguel Hernaez, Pedro J Rivero, Abian B Socorro, Aitor Urrutia, Pedro Sanchez, Pablo Zubiate, Diego Lopez-Torres, Nerea De Acha, Joaquin Ascorbe, Aritz Ozcariz, Ignacio R Matias
The measurement of chemical and biomedical parameters can take advantage of the features exclusively offered by optical fibre: passive nature, electromagnetic immunity and chemical stability are some of the most relevant ones. The small dimensions of the fibre generally require that the sensing material be loaded into a supporting matrix whose morphology is adjusted at a nanometric scale. Thanks to the advances in nanotechnology new deposition methods have been developed: they allow reagents from different chemical nature to be embedded into films with a thickness always below a few microns that also show a relevant aspect ratio to ensure a high transduction interface...
October 11, 2017: Sensors
Farhan Ahmad
Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized materials that are extensively applied in a variety of biomedical applications which includes diagnostic use, disease management, medical device coating, drug delivery and for personal health care. With the growing interest and the use of AgNPs in the health care sector, it is becoming essential for a better understanding of AgNPs mechanism of action like biological interaction, their possible toxicity, and safety concern to human exposure...
October 6, 2017: Recent Patents on Anti-infective Drug Discovery
Michelle Mann, Ellen R Fisher
The need for low-fouling coatings for biomedical devices has prompted considerable interest in antibacterial compounds from natural and sustainable sources, such as essential oils. Herein, a tea tree oil-based precursor, 1,8-cineole, is used to fabricate antimicrobial films (denoted ppCin) by plasma enhanced chemical vapor deposition. Film properties were comprehensively characterized using a variety of surface and bulk analytical tools and the plasma gas phase is assessed using optical emission spectroscopy, which can be correlated to ppCin film properties...
October 6, 2017: ACS Applied Materials & Interfaces
Lihong Wang
Lihong V. Wang summarizes his tenure as Editor-in-Chief of the Journal of Biomedical Optics and introduces his successor, Brian Pogue, who will assume the role in January 2018.
October 4, 2017: Journal of Biomedical Optics
Jiamiao Yang, Lei Gong, Xiao Xu, Pengfei Hai, Yuecheng Shen, Yuta Suzuki, Lihong V Wang
Photoacoustic microscopy (PAM) is uniquely positioned for biomedical applications because of its ability to visualize optical absorption contrast in vivo in three dimensions. Here we propose motionless volumetric spatially invariant resolution photoacoustic microscopy (SIR-PAM). To realize motionless volumetric imaging, SIR-PAM combines two-dimensional Fourier-spectrum optical excitation with single-element depth-resolved photoacoustic detection. To achieve spatially invariant lateral resolution, propagation-invariant sinusoidal fringes are generated by a digital micromirror device...
October 3, 2017: Nature Communications
Alexander Nicol, Wei Qin, Ryan T K Kwok, Jeffrey Mark Burkhartsmeyer, Zhenfeng Zhu, Huifang Su, Wenwen Luo, Jacky W Y Lam, Jun Qian, Kam Sing Wong, Ben Zhong Tang
Multiphoton microscopy is an exciting tool for biomedical research because it can be used to image single cells in vivo due to its greater penetration depth, lower phototoxicity and higher resolution when compared to confocal laser scanning microscopy. This helps researchers understand how certain cells change over time and evaluate the efficacy of different therapies. Herein, we report a new AIE luminogen (AIEgen), abbreviated as TPE-TETRAD, with a favorable absorption and efficient deep-red emission in the solid state...
June 1, 2017: Chemical Science
Omri Meitav, Oren Shaul, David Abookasis
Spectral data enabling the derivation of a biological tissue sample's complex refractive index (CRI) can provide a range of valuable information in the clinical and research contexts. Specifically, changes in the CRI reflect alterations in tissue morphology and chemical composition, enabling its use as an optical marker during diagnosis and treatment. In the present work, we report a method for estimating the real and imaginary parts of the CRI of a biological sample using Kramers-Kronig (KK) relations in the spatial frequency domain...
September 2017: Journal of Biomedical Optics
Zongda Zhu, Lu Liu, Zhihai Liu, Yu Zhang, Yaxun Zhang
We propose and demonstrate a novel and compact optical-fiber temperature sensor with a high sensitivity and high figure of merit (FOM) based on surface plasmon resonance (SPR). The sensor is fabricated by employing a single-mode twin-core fiber (TCF), which is polished as a circular truncated cone and coated with a layer of gold film and a layer of polydimethylsiloxane (PDMS). Owing to the high refractive index sensitivity of SPR sensors and high thermo-optic coefficient of PDMS, the sensor realizes a high temperature sensitivity of -4...
August 1, 2017: Optics Letters
Federico N Guerrero, Enrique M Spinelli
Sigma Delta analogue-to-digital converters allow acquiring the full dynamic range of biomedical signals at the electrodes, resulting in less complex hardware and increased measurement robustness. However, the increased data size per sample (typically 24 bits) demands the transmission of extremely large volumes of data across the isolation barrier, thus increasing power consumption on the patient side. This problem is accentuated when a large number of channels is used as in current 128-256 electrodes biopotential acquisition systems, that usually opt for an optic fibre link to the computer...
September 28, 2017: Journal of Medical Engineering & Technology
Yunyun Huang, Mingfei Ding, Tuan Guo, Dejiao Hu, Yaoyu Cao, Long Jin, Bai-Ou Guan
The feasibility of a localized surface plasmon resonance (LSPR) enhanced sensor based on raspberry-like nanosphere functionalized silica microfibers has been proposed and experimentally demonstrated. The extinction of single Ag (or Au) nanoparticles usually occurs at visible wavelengths. Nevertheless, a LSPR enhancement at near infrared wavelengths has been achieved by constructing raspberry-like meso-SiO2 nanospheres with noble metal nanoparticle cluster coating. The nanosphere coating captures γ-amino-butyric acid (GABA) targets through size selectivity and enhances the sensitivity by the LSPR effect...
October 12, 2017: Nanoscale
M Serra, D Ferraro, I Pereiro, J-L Viovy, S Descroix
Multiphase and droplet microfluidic systems are growing in relevance in bioanalytical-related fields, especially due to the increased sensitivity, faster reaction times and lower sample/reagent consumption of many of its derived bioassays. Often applied to homogeneous (liquid/liquid) reactions, innovative strategies for the implementation of heterogeneous (typically solid/liquid) processes have recently been proposed. These involve, for example, the extraction and purification of target analytes from complex matrices or the implementation of multi-step protocols requiring efficient washing steps...
September 26, 2017: Lab on a Chip
Lingling Chen, Guiye Li, Yamin Li, Yingchao Li, Haiou Zhu, Li Tang, Paul French, James McGinty, Shuangchen Ruan
Optical clearing methods can facilitate deep optical imaging in biological tissue by reducing light scattering and this has enabled accurate three-dimensional signal visualization and quantification of complex biological structures. Unfortunately, existing optical clearing approaches present a compromise between maximizing clearing capability, the preservation of fluorescent protein emission and membrane integrity and the speed of sample processing - with the latter typically requiring weeks for cm scale tissue samples...
September 22, 2017: Scientific Reports
Daniel Pérez, Ivana Gasulla, Lee Crudgington, David J Thomson, Ali Z Khokhar, Ke Li, Wei Cao, Goran Z Mashanovich, José Capmany
Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming...
September 21, 2017: Nature Communications
Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang, Huiqing Zhong, Zhouyi Guo
Ascribe to the unique two-dimensional planar nanostructure with exceptional physical and chemical properties, black phosphorous (BP) as the emerging inorganic two-dimensional nanomaterial with high biocompatibility and degradability has been becoming one of the most promising materials of great potentials in biomedicine. The exfoliated BP sheets possess ultra-high surface area available for valid bio-conjugation and molecular loading for chemotherapy. Utilizing the intrinsic near-infrared optical absorbance, BP-based photothermal therapy in vivo, photodynamic therapy and biomedical imaging has been realized, achieving unprecedented anti-tumor therapeutic efficacy in animal experiments...
September 20, 2017: Current Medicinal Chemistry
Barak Gilboa, Clément Lafargue, Amir Handelman, Linda J W Shimon, Gil Rosenman, Joseph Zyss, Tal Ellenbogen
Short peptides made from repeating units of phenylalanine self-assemble into a remarkable variety of micro- and nanostructures including tubes, tapes, spheres, and fibrils. These bio-organic structures are found to possess striking mechanical, electrical, and optical properties, which are rarely seen in organic materials, and are therefore shown useful for diverse applications including regenerative medicine, targeted drug delivery, and biocompatible fluorescent probes. Consequently, finding new optical properties in these materials can significantly advance their practical use, for example, by allowing new ways to visualize, manipulate, and utilize them in new, in vivo, sensing applications...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Nabila Eladawi, Mohammed M Elmogy, Mohammed Ghazal, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Shlomit Schaal, Ayman El-Baz
Optical Coherence Topography (OCT) is an emerging biomedical imaging technology that offers non-invasive real-time, high-resolution imaging of highly scattering tissues. It is widely used in ophthalmology to perform diagnostic imaging on the structure of the anterior eye and the retina. Clinical studies are carried out to assess the application of OCT for some retinal diseases. OCT can provide means for early detection for various types of diseases because morphological changes often occur before the physical symptoms of these diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
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