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https://www.readbyqxmd.com/read/29144073/evaluation-of-certain-food-additives
#1
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This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation of and assessment of dietary exposure to food additives, including flavouring agents. A summary follows of the Committee’s evaluations of technical, toxicological and dietary exposure data for 10 food additives (Allura Red AC; carob bean gum; lutein esters from Tagetes erecta; octenyl succinic acid (OSA)– modified gum arabic; pectin; Quinoline Yellow; rosemary extract; steviol glycosides; tartrazine; and xanthan gum) and five groups of flavouring agents (alicyclic, alicyclic-fused and aromatic-fused ring lactones; aliphatic and aromatic amines and amides; aliphatic secondary alcohols, ketones and related esters; cinnamyl alcohol and related substances; and tetrahydrofuran and furanone derivatives)...
2017: World Health Organization Technical Report Series
https://www.readbyqxmd.com/read/29126037/radiographic-evaluation-of-first-mtp-joint-arthrodesis-for-severe-hallux-valgus-does-the-introduction-of-a-lag-screw-improve-union-rates-and-correction-of-the-intermetatarsal-angle
#2
Zachariah Pinter, Parke Hudson, Brent Cone, Girish Motwani, Krishna Prasad, Ashish Shah
BACKGROUND: First metatarsophalangeal (MTP-1) joint fusion is a reliable method for the correction of various deformities including hallux valgus and hallux rigidus. Ideal constructs provide high rates of fusion in desired alignment. The present study examines the union rates, as well as the change in dorsiflexion angle during the follow up period in patients who underwent MTP-1 fusion with a dorsal locking plate and a lag screw, versus patients fused with a dorsal locking plate alone...
July 8, 2017: Foot
https://www.readbyqxmd.com/read/29081630/estimation-of-clean-and-centered-brain-network-atlases-using-diffusive-shrinking-graphs-with-application-to-developing-brains
#3
Islem Rekik, Gang Li, Weili Lin, Dinggang Shen
Many methods have been developed to spatially normalize a population of brain images for estimating a mean image as a population-average atlas. However, methods for deriving a network atlas from a set of brain networks sitting on a complex manifold are still absent. Learning how to average brain networks across subjects constitutes a key step in creating a reliable mean representation of a population of brain networks, which can be used to spot abnormal deviations from the healthy network atlas. In this work, we propose a novel network atlas estimation framework, which guarantees that the produced network atlas is clean (for tuning down noisy measurements) and well-centered (for being optimally close to all subjects and representing the individual traits of each subject in the population)...
June 2017: Information Processing in Medical Imaging: Proceedings of the ... Conference
https://www.readbyqxmd.com/read/29060261/fusing-motion-capture-and-inertial-measurements-for-improved-joint-state-recovery-an-application-for-sit-to-stand-actions
#4
Robert Peter Matthew, Sarah Seko, Ruzena Bajcsy
The estimate of joint angles, velocities, and accelerations is a key component of biomechanical modelling. The literature presents a variety of sensing modalities and algorithms to recover the full joint state, with tuning parameters varying between different applications, actions, and limbs. Comparisons between these methods are frequently limited to angles only, without comparison between the joint velocities and accelerations. This paper introduces an algorithm to fuse motion-capture and inertial measurements to recover the full state during a sit-to-stand task...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29047366/the-use-of-cinacalcet-hinders-the-diagnosis-of-parathyroid-carcinoma-in-a-chronic-dialysis-patient-a-case-report
#5
Daisuke Takada, Tatsuo Tsukamoto, Miho Fuse, Shinpei Kada, Motoko Yanagita
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. We present a case of parathyroid carcinoma partially controlled by cinacalcet, in which tumorous calcinosis was successfully resolved by total parathyroidectomy...
October 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29030223/3d-printed-multi-compartment-capsular-devices-for-two-pulse-oral-drug-delivery
#6
A Maroni, A Melocchi, F Parietti, A Foppoli, L Zema, A Gazzaniga
In the drug delivery area, versatile therapeutic systems intended to yield customized combinations of drugs, drug doses and release kinetics have drawn increasing attention, especially because of the advantages that personalized pharmaceutical treatments would offer. In this respect, a previously proposed capsular device able to control the release performance based on its design and composition, which could extemporaneously be filled, was improved to include multiple separate compartments so that differing active ingredients or formulations may be conveyed...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29026643/mineralized-collagen-artificial-bone-repair-material-products-used-for-fusing-the-podarthral-joints-with-internal-fixation-a-case-report
#7
Nihar S Ghate, Helen Cui
In this study, we reported a case with collapse and subluxation of metatarsal-cuneiform joint, navicular-cuneiform joint with subluxed the right first metatarsophalangeal joint. The injured medial column was internally fixed with compression arthrodesis. The fusion site was firmed up with BonGold® Bone Sponge and Bone Putty. The prognosis of fused navicular-cuneiform joint and metatarsal-cuneiform joint were examined by X-ray shortly after surgical operation and followed up 2, 4, 6, 9 and 13 weeks after the surgical operation...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28984388/educating-for-collaborative-practice-an-interpretation-of-current-achievements-and-thoughts-for-future-directions
#8
Judith Nicky Hudson, Anne Croker
CONTEXT: The Edinburgh Declaration, developed in 1998 as a pledge to alter the character of medical education to more effectively meet the needs of society, included a recommendation to increase the opportunity for joint learning between health and health-related professions, as part of the training for teamwork. This article acknowledges achievements since the Declaration in relation to this recommendation, using an umbrella term for the phenomenon, 'educating for collaborative practice', and presents a perspective framed as a series of questions to encourage reflection on future directions...
October 6, 2017: Medical Education
https://www.readbyqxmd.com/read/28954742/outcomes-of-orthopedic-surgery-in-a-cohort-of-49-patients-with-x-linked-hypophosphatemic-rickets-xlhr
#9
A Gizard, A Rothenbuhler, Z Pejin, G Finidori, C Glorion, B de Billy, A Linglart, P Wicart
BACKGROUND: X-linked hypophosphatemic rickets (XLHR) is due to mutations in PHEX leading to unregulated production of FGF23 and hypophosphatemia. XLHR is characterized by leg bowing of variable severity. Phosphate supplements and oral vitamin analogs, partially or, in some cases, fully restore the limb straightness. Surgery is the alternative for severe or residual limb deformities. OBJECTIVE: To retrospectively assess the results of surgical limb correction in XLHR (osteotomies and bone alignment except for 3 transient hemiepiphysiodesis)...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28934785/1-year-results-of-a-randomized-controlled-trial-of-conservative-management-vs-minimally-invasive-surgical-treatment-for-sacroiliac-joint-pain
#10
Julius Dengler Dengler, Djaya Kools, Robert Pflugmacher, Alessandro Gasbarrini, Domenico Prestamburgo, Paolo Gaetani, Eddie van Eeckhoven, Daniel Cher, Bengt Sturesson
BACKGROUND: Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. Devices to fuse the SIJ are now commercially available, but high-quality evidence supporting their effectiveness is limited. OBJECTIVES: To compare the safety and effectiveness of conservative management (CM) to minimally invasive sacroiliac joint fusion (SIJF) in patients with chronic LBP originating from the SIJ. STUDY DESIGN: Prospective, multicenter randomized controlled trial...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28922353/synthesizing-developmental-trajectories
#11
Paul Villoutreix, Joakim Andén, Bomyi Lim, Hang Lu, Ioannis G Kevrekidis, Amit Singer, Stanislav Y Shvartsman
Dynamical processes in biology are studied using an ever-increasing number of techniques, each of which brings out unique features of the system. One of the current challenges is to develop systematic approaches for fusing heterogeneous datasets into an integrated view of multivariable dynamics. We demonstrate that heterogeneous data fusion can be successfully implemented within a semi-supervised learning framework that exploits the intrinsic geometry of high-dimensional datasets. We illustrate our approach using a dataset from studies of pattern formation in Drosophila...
September 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28910770/global-local-temporal-saliency-action-prediction
#12
Shaofan Lai, Wei-Shi Zheng, Jian-Fang Hu, Jianguo Zhang
Action prediction on a partially observed action sequence is a very challenging task. To address this challenge, we first design a global-local distance model, where a global-temporal distance compares subsequences as a whole and local-temporal distance focuses on individual segment. Our distance model introduces temporal saliency for each segment to adapt its contribution. Finally, a global-local temporal action prediction model is formulated in order to jointly learn and fuse these two types of distances...
September 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28837224/a-framework-based-on-hidden-markov-trees-for-multimodal-pet-ct-image-co-segmentation
#13
Houda Hanzouli-Ben Salah, Jerome Lapuyade-Lahorgue, Julien Bert, Didier Benoit, Philippe Lambin, Angela Van Baardwijk, Emmanuel Monfrini, Wojciech Pieczynski, Dimitris Visvikis, Mathieu Hatt
PURPOSE: The purpose of this study was to investigate the use of a probabilistic quad-tree graph (hidden Markov tree, HMT) to provide fast computation, robustness and an interpretational framework for multimodality image processing and to evaluate this framework for single gross tumor target (GTV) delineation from both positron emission tomography (PET) and computed tomography (CT) images. METHODS: We exploited joint statistical dependencies between hidden states to handle the data stack using multi-observation, multi-resolution of HMT and Bayesian inference...
August 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28833609/magnetic-resonance-imaging-of-the-tensor-vastus-intermedius-a-topographic-study-based-on-anatomical-dissections
#14
Karl Grob, Mirjana Manestar, Dominic Gascho, Timothy Ackland, Helen Gilbey, Christian Fretz, Markus S Kuster
The tensor of the vastus intermedius (TVI) is a newly described component of the extensor apparatus of the knee joint. The objective of this study was to evaluate the appearance of the TVI on magnetic resonance (MR) imaging and its association with the adjacent vastus lateralis (VL) and vastus intermedius (VI) muscles and to compare these findings with the corresponding anatomy. MR images were analyzed from a cadaveric thigh where the TVI, as part of the extensor apparatus of the knee joint, had been dissected...
August 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28760124/interphalangeal-arthrodesis-using-an-intramedullary-nitinol-implant-a-prospective-study
#15
Markus Jakubek, Martin Enzendorfer, Rainer Fiala, Klemens Trieb
OBJECTIVES: This study aims to evaluate the nitinol (X-Fuse®) implant in arthrodesis of the distal interphalangeal and the thumb joints with respect to bone fusion and clinical efficiency. PATIENTS AND METHODS: This prospective study included 24 consecutive patients (7 males, 17 females; mean age 56.8 years; range 27 to 79 years) with nitinol (X-Fuse®) implants in their 41 joints. All patients were followed-up clinically and radiographically with respect to fusion, complications and outcome at a minimum of 14 months postoperatively (mean 28±6 months)...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28751371/wearable-knee-health-system-employing-novel-physiological-biomarkers
#16
Omer T Inan, Daniel C Whittingslow, Caitlin N Teague, Sinan Hersek, Maziyar Baran Pouyan, Mindy Millard-Stafford, Geza F Kogler, Michael N Sawka
Knee injuries and chronic disorders, such as arthritis, affect millions of Americans leading to missed workdays and reduced quality of life. Currently, after an initial diagnosis, there are few quantitative technologies available to provide sensitive sub-clinical feedback to patients regarding improvements or setbacks to their knee health status; instead, most assessments are qualitative, relying on patient-reported symptoms, performance during functional tests, and physical examinations. Recent advances have been made with wearable technologies for assessing the health status of the knee (and potentially other joints) with the goal of facilitating personalized rehabilitation of injuries and care for chronic conditions...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28727658/white-cell-and-marrow-imaging-subtracting-uncertainty
#17
Chelsey Turner, Alison A Bolster, Carolyn L Paterson, Hugh J Wallace
A subtraction method for assessments of dual-isotope indium-111 (In)-labelled white cell and Tc-nanocoll was proposed, and following a pilot study was introduced in routine service to improve the confidence of reporters. This technical note describes a simple technique to produce subtraction images from routinely acquired images to investigate and exclude post joint replacement infection. Labelled leucocytes (with In) show areas of increased white cell accumulation, whereas Tc-nanocoll images show bone marrow distribution...
July 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28716512/results-of-the-dubert-procedure-for-chronic-painful-fracture-dislocations-of-the-fifth-carpometacarpal-joint-a-report-of-6-cases
#18
N Meraghni, G Bacle, E Marteau, Y Bouju, J Laulan
Carpometacarpal (CMC) fracture-dislocations of the fifth ray are common. For chronic injuries, Dubert proposed combining resection arthroplasty of the base of the fifth metacarpal (M5) with synostosis with the fourth metacarpal (M4). Our aim was to evaluate the results of this procedure. Between 1994 and 2014, 7 men and 1 woman with an average age of 36 years (range, 27 to 45) were operated on. The right hand was involved in 6 of the 8 cases. All patients had symptomatic osteoarthritis secondary to isolated articular malunion and subluxation of the 5th CMC joint...
October 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28669858/pelvic-incidence-a-fixed-value-or-can-you-change-it
#19
Howard M Place, Ann M Hayes, Stephen B Huebner, Andy M Hayden, Heidi Israel, Jennifer L Brechbuhler
BACKGROUND CONTEXT: There has been renewed interest in the pelvic vertebrae by spinal surgeons recently. Those involved in working with patients with adult spinal deformity focus on the position of the fused spine as it relates to the pelvis, and determine success or failure by specific numbers for given pelvic parameters. The pelvic parameters that are commonly measured for these patients are pelvic tilt, sacral slope, and pelvic incidence (PI). Out of the three, PI has always been considered to be the fixed measurement, whereas pelvic tilt and sacral slope have the capacity to change in relation to external forces...
June 29, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28666884/bioinspired-coupled-helical-coils-for-soft-tissue-engineering-of-tubular-structures-improved-mechanical-behavior-of-tubular-collagen-type-i-templates
#20
H P Janke, J Bohlin, R M L M Lomme, S M Mihaila, J Hilborn, W F J Feitz, E Oosterwijk
The design of constructs for tubular tissue engineering is challenging. Most biomaterials need to be reinforced with supporting structures such as knittings, meshes or electrospun material to comply with the mechanical demands of native tissues. In this study, coupled helical coils (CHCs) were manufactured to mimic collagen fiber orientation as found in nature. Monofilaments of different commercially available biodegradable polymers were wound and subsequently fused, resulting in right-handed and left-handed polymer helices fused together in joints where the filaments cross...
September 1, 2017: Acta Biomaterialia
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