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https://www.readbyqxmd.com/read/28922353/synthesizing-developmental-trajectories
#1
Paul Villoutreix, Joakim Andén, Bomyi Lim, Hang Lu, Ioannis G Kevrekidis, Amit Singer, Stanislav Y Shvartsman
Dynamical processes in biology are studied using an ever-increasing number of techniques, each of which brings out unique features of the system. One of the current challenges is to develop systematic approaches for fusing heterogeneous datasets into an integrated view of multivariable dynamics. We demonstrate that heterogeneous data fusion can be successfully implemented within a semi-supervised learning framework that exploits the intrinsic geometry of high-dimensional datasets. We illustrate our approach using a dataset from studies of pattern formation in Drosophila...
September 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28910770/global-local-temporal-saliency-action-prediction
#2
Shaofan Lai, Wei-Shi Zheng, Jian-Fang Hu, Jianguo Zhang
Action prediction on a partially observed action sequence is a very challenging task. To address this challenge, we first design a global-local distance model, where a global-temporal distance compares subsequences as a whole and local-temporal distance focuses on individual segment. Our distance model introduces temporal saliency for each segment to adapt its contribution. Finally, a global-local temporal action prediction model is formulated in order to jointly learn and fuse these two types of distances...
September 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28837224/a-framework-based-on-hidden-markov-trees-for-multimodal-pet-ct-image-co-segmentation
#3
Houda Hanzouli-Ben Salah, Jerome Lapuyade-Lahorgue, Julien Bert, Didier Benoit, Philippe Lambin, Angela Van Baardwijk, Emmanuel Monfrini, Wojciech Pieczynski, Dimitris Visvikis, Mathieu Hatt
PURPOSE: To investigate the use of a probabilistic quad-tree graph (Hidden Markov Tree, HMT) to provide fast computation, robustness and an interpretational framework for multimodality image processing and to evaluate this framework for single gross tumor target (GTV) delineation from both positron emission tomography (PET) and computed tomography (CT) images. METHODS: We exploited joint statistical dependencies between hidden states to handle the data stack using multi-observation, multi-resolution of HMT and Bayesian inference...
August 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28833609/magnetic-resonance-imaging-of-the-tensor-vastus-intermedius-a-topographic-study-based-on-anatomical-dissections
#4
K Grob, M Manestar, D Gascho, T Ackland, H Gilbey, Kuster, Ch Fretz
The tensor of the vastus intermedius (TVI) is a newly described component of the extensor apparatus of the knee joint. The objective of this study was to evaluate the appearance of the TVI on magnetic resonance (MR) imaging and its association with the adjacent vastus lateralis (VL) and vastus intermedius (VI) muscles and to compare these findings with the corresponding anatomy. MR images were analyzed from a cadaveric thigh where the TVI, as part of the extensor apparatus of the knee joint, had been dissected...
August 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28760124/interphalangeal-arthrodesis-using-an-intramedullary-nitinol-implant-a-prospective-study
#5
Markus Jakubek, Martin Enzendorfer, Rainer Fiala, Klemens Trieb
OBJECTIVES: This study aims to evaluate the nitinol (X-Fuse®) implant in arthrodesis of the distal interphalangeal and the thumb joints with respect to bone fusion and clinical efficiency. PATIENTS AND METHODS: This prospective study included 24 consecutive patients (7 males, 17 females; mean age 56.8 years; range 27 to 79 years) with nitinol (X-Fuse®) implants in their 41 joints. All patients were followed-up clinically and radiographically with respect to fusion, complications and outcome at a minimum of 14 months postoperatively (mean 28±6 months)...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28751371/wearable-knee-health-system-employing-novel-physiological-biomarkers
#6
Omer T Inan, Daniel C Whittingslow, Caitlin N Teague, Sinan Hersek, Maziyar Baran Pouyan, Mindy Millard-Stafford, Geza F Kogler, Michael N Sawka
Knee injuries and chronic disorders, such as arthritis, affect millions of Americans leading to missed workdays and reduced quality of life. Currently, after an initial diagnosis, there are few quantitative technologies available to provide sensitive sub-clinical feedback to patients regarding improvements or setbacks to their knee health status; instead, most assessments are qualitative, relying on patient-reported symptoms, performance during functional tests, and physical examinations. Recent advances have been made with wearable technologies for assessing the health status of the knee (and potentially other joints) with the goal of facilitating personalized rehabilitation of injuries and care for chronic conditions...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28727658/white-cell-and-marrow-imaging-subtracting-uncertainty
#7
Chelsey Turner, Alison A Bolster, Carolyn L Paterson, Hugh J Wallace
A subtraction method for assessments of dual-isotope indium-111 (In)-labelled white cell and Tc-nanocoll was proposed, and following a pilot study was introduced in routine service to improve the confidence of reporters. This technical note describes a simple technique to produce subtraction images from routinely acquired images to investigate and exclude post joint replacement infection. Labelled leucocytes (with In) show areas of increased white cell accumulation, whereas Tc-nanocoll images show bone marrow distribution...
July 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28716512/results-of-the-dubert-procedure-for-chronic-painful-fracture-dislocations-of-the-fifth-carpometacarpal-joint-a-report-of-6-cases
#8
N Meraghni, G Bacle, E Marteau, Y Bouju, J Laulan
Carpometacarpal (CMC) fracture-dislocations of the fifth ray are common. For chronic injuries, Dubert proposed combining resection arthroplasty of the base of the fifth metacarpal (M5) with synostosis with the fourth metacarpal (M4). Our aim was to evaluate the results of this procedure. Between 1994 and 2014, 7 men and 1 woman with an average age of 36 years (range, 27 to 45) were operated on. The right hand was involved in 6 of the 8 cases. All patients had symptomatic osteoarthritis secondary to isolated articular malunion and subluxation of the 5th CMC joint...
July 14, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28669858/pelvic-incidence-a-fixed-value-or-can-you-change-it
#9
Howard M Place, Ann M Hayes, Stephen B Huebner, Andy M Hayden, Heidi Israel, Jennifer L Brechbuhler
BACKGROUND CONTEXT: There has been renewed interest in the pelvic vertebrae by spinal surgeons recently. Those involved in working with patients with adult spinal deformity, focus on the position of the fused spine as it relates to the pelvis, and determine success or failure by specific numbers for given pelvic parameters. The pelvic parameters that are commonly measured for these patients are pelvic tilt, sacral slope, and pelvic incidence. Out of the three, pelvic incidence has always been considered to be the fixed measurement, while pelvic tilt and sacral slope have the capacity to change in relation to external forces...
June 29, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28666884/bioinspired-coupled-helical-coils-for-soft-tissue-engineering-of-tubular-structures-improved-mechanical-behavior-of-tubular-collagen-type-i-templates
#10
H P Janke, J Bohlin, R M L M Lomme, S M Mihaila, J Hilborn, W F J Feitz, E Oosterwijk
The design of constructs for tubular tissue engineering is challenging. Most biomaterials need to be reinforced with supporting structures such as knittings, meshes or electrospun material to comply with the mechanical demands of native tissues. In this study, coupled helical coils (CHCs) were manufactured to mimic collagen fiber orientation as found in nature. Monofilaments of different commercially available biodegradable polymers were wound and subsequently fused, resulting in right-handed and left-handed polymer helices fused together in joints where the filaments cross...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28611327/overgrowth-of-costochondral-graft-in-temporomandibular-joint-ankylosis-reconstruction-a-retrospective-study
#11
S M Balaji, Preetha Balaji
BACKGROUND: Temporomandibular joint (TMJ) ankylosis is a situation in which the mandibular condyle is fused to the glenoid fossa by bone or fibrous tissue. The management of TMJ ankylosis has a complicated chore, and it is challenging for the maxillofacial surgeon because of technical hitches and high rate of reankylosis. Costochondral graft (CCG) is a common treatment modality for TMJ ankylosis. One of disadvantages of CCG is unpredictability of growth pattern and risk of overgrowth...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28610254/three-new-macropsini-hemiptera-cicadellidae-leafhopper-species-from-australia
#12
Liyuan Yang, Christopher H Dietrich, Yalin Zhang
Three new species, Macropsella recta, Toropsis minuspina and Varicopsella apecurvata spp. nov. are described and illustrated from Australia.       Leafhoppers of the subfamily Macropsinae are found abundantly in the Holarctic, Oriental and Australian regions (Linnavuori, 1978) and have been collected from around the world, except for Antarctica, Oceania and South America (Hamilton, 1980). Both Hamilton (1980) and Evans (1966) suggested that there were likely a myriad of uncollected and undescribed species in Australia alone and Evans (1971) commented that the Macropsinae are possibly more abundant in Australia than anywhere else in the world...
June 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28597301/osteoarthritis-and-spontaneous-fusion-of-facet-joints-after-percutaneous-instrumentation-in-thoracolumbar-fractures
#13
Alix Tromme, Yann Philippe Charles, Sébastien Schuller, Axel Walter, Mickaël Schaeffer, Jean-Paul Steib
PURPOSE: This retrospective study determined the rate of osteoarthritis and spontaneous facet joint fusion and analyzed risk factors related to patient characteristics, fracture type or surgical technique on pre- and postoperative CT after percutaneous instrumentation in thoracolumbar fractures. METHODS: 1050 facet joints adjacent to screws in 148 patients (15-85 years) with thoracolumbar fractures were analyzed with an average time between CTs of 12.3 months...
June 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28582269/automated-diagnosis-of-prostate-cancer-in-multi-parametric-mri-based-on-multimodal-convolutional-neural-networks
#14
Minh Hung Le, Jingyu Chen, Liang Wang, Zhiwei Wang, Wenyu Liu, Kwang-Ting Tim Cheng, Xin Yang
Automated methods for prostate cancer (PCa) diagnosis in multi-parametric magnetic resonance images (MP-MRI) are critical for increasing the survival rate of patients and alleviating requirements in radiology reading and reducing risk of over-/under-treatment. This paper presents an automated method based on multimodal convolutional neural networks (CNNs) for two PCa diagnosis tasks: 1) distinguishing between cancer and noncancerous tissues, 2) distinguishing between clinically significant (CS) and indolent PCa...
June 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28560871/forecasting-chronic-diseases-using-data-fusion
#15
Evrim Acar, Gözde Gürdeniz, Francesco Savorani, Louise Hansen, Anja Olsen, Anne Tjønneland, Lars Ove Dragsted, Rasmus Bro
Data fusion, that is, extracting information through the fusion of complementary data sets, is a topic of great interest in metabolomics because analytical platforms such as liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy commonly used for chemical profiling of biofluids provide complementary information. In this study, with a goal of forecasting acute coronary syndrome (ACS), breast cancer, and colon cancer, we jointly analyzed LC-MS, NMR measurements of plasma samples, and the metadata corresponding to the lifestyle of participants...
June 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28553387/case-of-atlantoaxial-dislocation-with-assimilated-c1-absent-posterior-c2-butterfly-c3-and-fused-subaxial-cervical-spine-management-dilemma-with-multiple-segmentation-and-formation-defects
#16
Arsikere N Deepak, Pravin Salunke, Rajeev P Kamble
Segmentation defects are often seen with congenital atlantoaxial dislocation (AAD) though an associated absence of posterior arch of C2 and butterfly C3 is rare. Apart from rarity, the combination of formation and segmentation defects adds to the management dilemma. We report a case of AAD with assimilated atlas, absent C2 posterior arch, C3 butterfly vertebra with floating posterior elements, and fused C4-C6. The child was managed by C1-C2 fusion alone with immediate symptomatic improvement. The presence of formation defects such as adjacent butterfly vertebra and absent posterior elements does not alter the management of AAD...
January 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28552666/effects-of-force-detecting-sense-organs-on-muscle-synergies-are-correlated-with-their-response-properties
#17
Sasha N Zill, David Neff, Sumaiya Chaudhry, Annelie Exter, Josef Schmitz, Ansgar Büschges
Sense organs that monitor forces in legs can contribute to activation of muscles as synergist groups. Previous studies in cockroaches and stick insects showed that campaniform sensilla, receptors that encode forces via exoskeletal strains, enhance muscle synergies in substrate grip. However synergist activation was mediated by different groups of receptors in cockroaches (trochanteral sensilla) and stick insects (femoral sensilla). The factors underlying the differential effects are unclear as the responses of femoral campaniform sensilla have not previously been characterized...
July 3, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/28493649/temperature-driven-planar-chirality-switching-of-a-pillar-5-arene-based-molecular-universal-joint
#18
Jiabin Yao, Wanhua Wu, Wenting Liang, Yujun Feng, Dayang Zhou, Jason J Chruma, Gaku Fukuhara, Tadashi Mori, Yoshihisa Inoue, Cheng Yang
The study of an enantiopure bicyclic pillar[5]arene-based molecular universal joint (MUJ) by single-crystal X-ray diffraction allowed for the first time the unequivocal assignment of the absolute configuration of a planar chiral pillar[5]arene by circular dichroism spectroscopy. Crucially, the absolute configuration of the MUJ was switched reversibly by temperature, with an accompanying sign inversion of the anisotropy factor that varied by as much as 0.03, which is the largest value ever reported. Mechanistically, the reversible chirality switching of the MUJ is driven by the threading/dethreading motion of the fused ring and hence is dependent on both the size and nature of the ring and the solvent employed, reflecting the critical balance between the self-complexation of the ring by pillar[5]arene, the solvation to the excluded ring, and the inclusion of solvent molecules in the cavity...
May 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28480581/automatic-quantification-of-bone-marrow-edema-on-mri-of-the-wrist-in-patients-with-early-arthritis-a-feasibility-study
#19
Evgeni Aizenberg, Edgar A H Roex, Wouter P Nieuwenhuis, Lukas Mangnus, Annette H M van der Helm-van Mil, Monique Reijnierse, Johan L Bloem, Boudewijn P F Lelieveldt, Berend C Stoel
PURPOSE: To investigate the feasibility of automatic quantification of bone marrow edema (BME) on MRI of the wrist in patients with early arthritis. METHODS: For 485 early arthritis patients (clinically confirmed arthritis of one or more joints, symptoms for less than 2 years), MR scans of the wrist were processed in three automatic stages. First, super-resolution reconstruction was applied to fuse coronal and axial scans into a single high-resolution 3D image. Next, the carpal bones were located and delineated using atlas-based segmentation...
May 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28463696/spinal-fusion-without-instrumentation-experimental-animal-study
#20
Sandra Reitmaier, Julian Schuelke, Hendrik Schmidt, David Volkheimer, Anita Ignatius, Hans-Joachim Wilke
BACKGROUND: The number and cost of instrumented spinal fusion surgeries have increased rapidly, primarily for the treatment of lumbar segmental instabilities. However, what if the organism itself is able to restore segmental stability over time? This large-animal study using sheep aimed to investigate whether the reparative response after destabilization via facetectomy and nucleotomy without instrumentation can effectively fuse the spinal segment comparable to instrumented standard fusion surgery...
April 25, 2017: Clinical Biomechanics
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