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https://www.readbyqxmd.com/read/28182023/a-randomized-single-blind-parallel-group-study-comparing-monoherbal-formulation-containing-holarrhena-antidysenterica-extract-with-mesalamine-in-chronic-ulcerative-colitis-patients
#1
Sarika Johari, Tejal Gandhi
BACKGROUND: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. AIMS AND OBJECTIVES: This study aims to compare the treatment with monoherbal formulation of Holarrhena antidysenterica with Mesalamine in chronic ulcerative colitis patients with special emphasis to side effects and relapse. SETTINGS AND DESIGN: Patients were enrolled from an Ayurveda Hospital and a private Hospital, Gujarat...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28160856/vasculoprotective-and-vasodilatation-effects-of-herbal-formula-sahatsatara-and-piperine-in-spontaneously-hypertensive-rats
#2
Suksalin Booranasubkajorn, Sukit Huabprasert, Jantanee Wattanarangsan, Pruksa Chotitham, Pinpilai Jutasompakorn, Tawee Laohapand, Pravit Akarasereenont, Pinpat Tripatara
BACKGROUND: The herbal formula (Sahatsatara, STF), the Thai traditional poly-herbal recipe, has been used for treatment of muscle pain, anti-flatulence and numbness on hands and feet, with the caution when used in hypertensive patients. However, there is no scientific evidence to prove its effects on cardiovascular system. Piperine is the proposed major active compound in STF. It is shown to have antihypertensive effect in the L-NAME-induced endothelial dysfunction rats. PURPOSE: This study investigated the pharmacokinetics, mechanism of action, as well as the hemodynamic and vasoactive effect and toxicity of STF and piperine using spontaneously hypertensive rats (SHR) and normal Wistar rats (NWR)...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28126395/a-pooled-analysis-of-adverse-events-in-393-adults-with-gaucher-disease-type-1-from-four-clinical-trials-of-oral-eliglustat-evaluation-of-frequency-timing-and-duration
#3
M Judith Peterschmitt, Gerald F Cox, Jennifer Ibrahim, James MacDougall, Lisa H Underhill, Palni Patel, Sebastiaan J M Gaemers
Eliglustat, an oral substrate reduction therapy, is a first-line therapy for adults with Gaucher disease type 1 and a compatible CYP2D6 metabolizer phenotype. Clinicians have requested more information about frequency, timing, and duration of adverse events associated with eliglustat. Adverse event data as of January 31, 2013 for all patients who received at least one dose of eliglustat were pooled from four eliglustat clinical trials (393 patients representing 535 patient-years of exposure). The following 10 adverse events noted in the eliglustat US Prescribing Information (USPI) and EU Summary of Product Characteristics (SmPC) were evaluated with regard to frequency, drug-relatedness, severity, seriousness, duration, and timing of onset: headache, arthralgia, diarrhea, nausea, fatigue, flatulence, abdominal pain, upper abdominal pain, back pain, and extremity pain...
January 13, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28107842/mentha-spicata-as-natural-analgesia-for-treatment-of-pain-in-osteoarthritis-patients
#4
REVIEW
Mohaddese Mahboubi
Osteoarthritis, as the major cause of chronic musculoskeletal pain, impacts people aged 45 and above. The first line analgesic treatments have reported minimal short term effects. The use of essential oils as pain killer has increased, recently. Mentha spicata, or spearmint essential oil is famous due to its anti-flatulence effects, but one less known biological activity of spearmint is its analgesic activity. The aim of our study was to confirm the analgesic effects of M. spicata essential oil. In this review, we evaluated the articles on analgesic activities of M...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/27987248/understanding-and-overcoming-metformin-gastrointestinal-intolerance
#5
REVIEW
Fabrice Bonnet, André Scheen
Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). GI AEs typically encountered with metformin therapy include diarrhoea, nausea, flatulence, indigestion, vomiting, and abdominal discomfort, with diarrhoea and nausea being the most common...
December 17, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27982557/incorrect-position-of-the-bite-block-lead-to-serious-gastrointestinal-flatulence-during-gynecological-laparoscopic-surgery
#6
Yuangui Lin, Dong Luo, Linli Luo
No abstract text is available yet for this article.
December 16, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27966414/-design-of-artificial-foetor-flatus-based-on-bacterial-volatile-compounds
#7
Ulrik Stenz Justesen
INTRODUCTION: Excessive flatulence can be a huge social problem. The purpose of this study was to design artificial flatus from bacterial volatile compounds to stimulate research into neutralizing measures. MATERIAL AND METHODS: Anaerobic bacteria, representing a broad spectrum, from a recognized international culture collection were included. The strains were incubated in an anaerobic jar. After 24 hours the lid was removed, and the odour was evaluated by a specialist in clinical microbiology...
December 12, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27884550/effects-of-changing-the-amount-and-source-of-dietary-carbohydrates-on-symptoms-and-dietary-satisfaction-over-a-1-year-period-in-subjects-with-type-2-diabetes-canadian-trial-of-carbohydrates-in-diabetes-ccd
#8
Thomas M S Wolever, Jean-Louis Chiasson, Robert G Josse, Lawrence A Leiter, Pierre Maheux, Rémi Rabasa-Lhoret, N Wilson Rodger, Edmond A Ryan
OBJECTIVES: To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS: Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index (HGI) diets; high-carbohydrate/low-glycemic-index (LGI) diets; or lower-carbohydrate/high-monounsaturated-fat (LC) diets for 1 year. We measured QOL at baseline and at study's end, and we measured symptoms and dietary satisfaction quarterly...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27870785/abdominal-pain-caused-by-a-potentially-fatal-attraction
#9
Danielle Claire Mercurio, Candace Scace, Bhairav Shah, Evan Weiner, Rajeev Prasad
Abdominal pain is a challenging presentation in children. Examination findings and etiology vary greatly, spanning a vast spectrum from flatulence to frank peritonitis with septic shock. Here, we discuss a 10-year-old boy with 24 hours of progressively worsening lower abdominal pain, nausea, and subjective fevers. History and physical examination findings were consistent with appendicitis. However, physicians were surprised when the single-view abdominal radiograph showed an unanticipated, somewhat perplexing discovery...
November 19, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27845950/carbon-dioxide-insufflation-during-colonoscopy-in-inflammatory-bowel-disease-patients-a-double-blind-randomized-single-center-trial
#10
Přemysl Falt, Vít Šmajstrla, Petr Fojtík, Martin Hill, Ondřej Urban
OBJECTIVE: Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO2 insufflation have never been studied in inflammatory bowel disease (IBD) patients, characterized by younger age, structural changes of the colon, and need for repeated and frequently uncomfortable colonoscopies. Our trial was designed to evaluate postprocedural discomfort associated with CO2 compared with air insufflation in unsedated or minimally sedated patients with known IBD...
March 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27834802/prevalence-and-characterization-of-self-reported-gluten-sensitivity-in-the-netherlands
#11
Tom van Gils, Petula Nijeboer, Catharina E IJssennagger, David S Sanders, Chris J J Mulder, Gerd Bouma
BACKGROUND: A growing number of individuals reports symptoms related to the ingestion of gluten-containing food in the absence of celiac disease. Yet the actual prevalence is not well established. METHODS: Between April 2015 and March 2016, unselected adults visiting marketplaces, dental practices and a university in The Netherlands were asked to complete a modified validated questionnaire for self-reported gluten sensitivity (srGS). RESULTS: Among the 785 adults enquired, two had celiac disease...
November 8, 2016: Nutrients
https://www.readbyqxmd.com/read/27815960/evaluation-of-cytotoxic-analgesic-antidiarrheal-and-phytochemical-properties-of-hygrophila-spinosa-t-anders-whole-plant
#12
S M Faysal Bellah, Md Nur Islam, Md Rezaul Karim, Md Masudur Rahaman, Mst Samima Nasrin, Md Atiar Rahman, A S M Ali Reza
BACKGROUND: Synthetic drugs are going to be replaced by plant-derived traditional drugs due to their cost effectiveness, relatively less harmfulness, and efficacy against multidrug resistance organisms. Hygrophila spinosa (Acanthaceae) has been used in a wide range of ailments including flatulence, diarrhea, dysentery, gonorrhea, and menorrhagia. Therefore, we investigated the cytotoxic, antinociceptive, and antidiarrheal effects of H. spinosa ethanol extract (EExHs). METHODS: Preliminary phytochemical screening was accomplished by established methods modified in experimental protocol...
November 5, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27791225/gastro-intestinal-tolerance-and-renal-safety-of-protein-oral-nutritional-supplements-in-nursing-home-residents-a-randomized-controlled-trial
#13
P Ter Wee, M Kuhn, H van der Woude, D Van De Looverbosch, H Heyman, L Mikušová, D Fouque
BACKGROUND/OBJECTIVE: High protein oral nutritional supplements (ONS) are regularly prescribed to undernourished patients; however usage of these in older adults is being discussed, as their renal function might have declined with age. Therefore, the aim of the current study was to evaluate the effects of 8 week long consumption of high protein ONS on the renal function of nursing home residents in need of supplementation. Furthermore, within the same setup, differences in gastro-intestinal tolerance between a standard and a more concentrated version of an ONS were investigated...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27765806/perforated-jejunal-diverticulum-a-rare-case-of-acute-abdomen
#14
Rishabh Sehgal, Cherry X Cheung, Tristram Hills, Aqueel Waris, Donagh Healy, Tahir Khan
Jejunal pseudo-diverticulosis is a rare acquired herniation of the mucosa and submucosa through weakened areas of the muscularis mucosa of the mesenteric aspect of the bowel. They are asymptomatic in the majority of cases; however, they can present with a wide spectrum of non-specific symptoms such as chronic abdominal discomfort, postprandial flatulence, diarrhoea, malabsorption and steattorhoea. In up to 15% of cases, more serious acute complications may arise such as the development of intestinal obstruction, haemorrhage or as in our case, localized peritonitis secondary to perforation...
October 7, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27763879/a-prospective-descriptive-study-to-assess-the-effect-of-dietary-and-pharmacological-strategies-to-manage-constipation-in-patients-with-a-stoma
#15
Lukasz Krokowicz, Adam Bobkiewicz, Maciej Borejsza-Wysocki, Barbara Kuczynska, Aleksandra Lisowska, Urszula Skowronska-Piekarska, Jacek Paszkowski, Jaroslaw Walkowiak, Michal Drews, Tomasz Banasiewicz
The term constipation with regard to patients with a stoma is defined as impaired bowel movements associated with increased stool consistency or long periods without bowel movements that lead to discomfort, flatulence, and abdominal pain. Information about constipation in patients with a stoma is limited. A prospective, descriptive study was conducted among patients attending ostomy and proctology outpatient clinics in Poznan, Poland between January 2011 and December 2014 to assess the role of dietary and pharmacological strategies in the management of constipation in patients with a stoma...
December 2015: Ostomy/wound Management
https://www.readbyqxmd.com/read/27753627/minimally-symptomatic-hypocalcaemia-unmasking-celiac-disease
#16
A Lazaridis, M E Drosou, A Fontalis, E Prousali, S E Hadwe, O Giouleme, K Petidis
INTRODUCTION: Celiac disease is an autoimmune disease of the small intestine which occurs in genetically predisposed people of all ages. A large clinical spectrum of manifestations accompanies the onset of the disease with diarrhoea, flatulence and weight loss being the most common. However, findings like osteoporosis, iron deficiency, anaemia and hypocalcaemia could also insinuate the existence of the disease. CASE PRESENTATION: We report the case of a 55-year-old man with numbness and tingling of the upper extremities due to hypocalcaemia that proved to be an uncommon case of celiac disease...
November 2016: Scottish Medical Journal
https://www.readbyqxmd.com/read/27749931/gastrointestinal-symptoms-in-hiv-infected-patients-female-sex-and-smoking-as-risk-factors-in-an-outpatient-cohort-in-brazil
#17
Annelisa Silva E Alves de Carvalho Santos, Erika Aparecida Silveira, Marianne de Oliveira Falco
This study aimed to estimate the incidence of gastrointestinal symptoms (GIS) and associated factors in an outpatient cohort of people living with HIV/AIDS (PLWHA) followed between October 2009 and July 2011. We evaluated nausea and/or vomiting, dyspepsia, heartburn, diarrhea, constipation, and flatulence. The outcome variable was the presence of three or more GIS. Sociodemographic (sex, skin color, age, income, years of schooling), lifestyle (smoking status, alcohol consumption, physical activity level), clinical (antiretroviral therapy, time of HIV infection, CD4 lymphocyte count, viral load), and anthropometric (nutritional status and waist circumference) variables were investigated...
2016: PloS One
https://www.readbyqxmd.com/read/27717787/a-protease-resistant-%C3%AE-galactosidase-from-pleurotus-djamor-with-broad-ph-stability-and-good-hydrolytic-activity-toward-raffinose-family-oligosaccharides
#18
Yujing Hu, Guoting Tian, Liyan Zhao, Hexiang Wang, Tzi Bun Ng
An acidic α-galactosidase designated as PDGI (Pleurotus djamor α-galactosidase) was purified to homogeneity with 290-fold purification and a specific activity of 52.18 units/mg by means of ion exchange chromatography and gel filtration chromatography. PDGI is a monomeric protein exhibiting a molecular mass of 60kDa in SDS-PAGE and gel filtration. The optimum pH and temperature of the enzyme with pNPGal as substrate were 5.0 and 53.5°C, respectively. It displayed great pH stability within the pH range 3.0-10...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27716759/-correlation-between-the-presence-and-intensity-of-symptoms-and-the-results-of-hydrogen-breath-tests-in-the-diagnosis-of-carbohydrate-intolerance
#19
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27698967/the-effect-of-probiotic-plus-prebiotic-supplementation-on-the-tolerance-and-efficacy-of-helicobacter-pylori-eradication-quadruple-therapy-a-randomized-prospective-double-blind-controlled-trial
#20
Afshin Shafaghi, Aydin Pourkazemi, Mohsen Khosravani, Saba Fakhrie Asl, Alireza Amir Maafi, Zahra Atrkar Roshan, Jafar Abaspour Rahimabad
BACKGROUND Standard anti-Helicobacter pylori (H. pylori) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti H. pylori quadruple therapy...
July 2016: Middle East Journal of Digestive Diseases
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