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5-aminolevulinic acid

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https://www.readbyqxmd.com/read/28338432/dual-labeling-with-5-aminolevulinic-acid-and-fluorescein-for-fluorescence-guided-resection-of-high-grade-gliomas-technical-note
#1
Eric Suero Molina, Johannes Wölfer, Christian Ewelt, André Ehrhardt, Benjamin Brokinkel, Walter Stummer
OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas. However, one limitation is the low intensity of blue light for background illumination. Fluorescein has recently been reintroduced into neurosurgery, and novel microscope systems are available for visualizing this fluorochrome, which highlights all perfused tissues but has limited selectivity for tumor detection. Here, the authors investigate a combination of both fluorochromes: 5-ALA for distinguishing tumor and fluorescein for providing tissue fluorescence of adjacent brain tissue...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28338177/5-aminolevulinic-acid-photodynamic-therapy-stimulates-local-immunity-in-patients-with-condylomata-acuminata-via-activation-of-t-lymphocytes
#2
J Du, Q Cheng, Z Zhang, J-F Wu, F Li, S-Y Chen, Y-L Wang, X-N Lu, J-H Xu
OBJECTIVE: 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT) for condylomata acuminate (CA) is effective and safe, but how this treatment affects immune reaction is poorly understood. We aimed to explore the effects of PDT on local immunity in CA. PATIENTS AND METHODS: Immunohistochemical analysis before and after PDT was performed to analyze local changes in the distribution of T lymphocytes, CD123+ plasmacytoid dendritic cells (pDCs) and CD1a+ myeloid DCs...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28336806/fluorouracil-enhances-photodynamic-therapy-of-squamous-cell-carcinoma-via-a-p53-independent-mechanism-that-increases-protoporphyrin-ix-levels-and-tumor-cell-death
#3
Sanjay Anand, Kishore R Rollakanti, Niokelta Brankov, Douglas E Brash, Tayyaba Hasan, Edward V Maytin
Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic keratoses (AK). In the United States, PDT is only FDA approved for treatment of AK; this narrow range of indications could be broadened if PDT efficacy were improved. Toward that goal, we developed a mechanism-based combination approach using 5-fluorouracil (5-FU) as a neoadjuvant for ALA-based PDT...
March 23, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28330814/ala-pdt-suppressing-the-cell-growth-and-reducing-the-lipogenesis-in-human-sz95-sebocytes-by-mtor-signaling-pathway-in-vitro
#4
Jiang Tuo, Qianqian Wang, Ye Liu, Ying Ma, Li Ma, Jiayi Ying, Chengfeng Zhang, Leihong Xiang
BACKGROUND: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, thetherapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate theeffects and mechanisms of ALA-PDTon the cell growth and lipogenesis of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of ALA-PDT...
March 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28321653/5-aminolevulinic-acid-modulates-antioxidant-defense-systems-and-mitigates-drought-induced-damage-in-kentucky-bluegrass-seedlings
#5
Kuiju Niu, Xiang Ma, Guoling Liang, Huiling Ma, Zhifeng Jia, Wenhui Liu, Qianqian Yu
Drought stress occurs frequently and severely as a result of global climate change, and it exerts serious effects on plants. 5-Aminolevulinic acid (5-ALA) plays a crucial role in conferring abiotic stress tolerance in plants. To enhance the drought tolerance of turfgrass and investigate the effects of 5-ALA on antioxidant metabolism and gene expression under drought stress conditions, exogenous 5-ALA was applied by foliar spraying before Kentucky bluegrass (Poa pratensis L.) seedlings were exposed to drought [induced by 10% polyethylene glycol (PEG)] stress for 20 days...
March 20, 2017: Protoplasma
https://www.readbyqxmd.com/read/28319501/18f-fluorocholine-pet-ct-brain-mri-and-5-aminolevulinic-acid-for-the-assessment-of-tumor-resection-in-high-grade-glioma
#6
Ana María García Vicente, Fátima Jiménez Aragón, Maikal Villena Martín, German Andrés Jiménez Londoño, Jose María Borrás Moreno
High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome. We present the case of a 57-year-old man with a brain lesion suggestive of high-grade glioma. Brain MRI and F-fluorocholine PET/CT were performed previously to plan the surgery. Surgery was microscope assisted after the administration of 5-aminolevulinic acid. Postsurgery brain MRI and PET were blind evaluated to the surgery results and reported as probably gross total resection.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28314866/a-clinical-trial-using-attrition-combined-with-5-aminolevulinic-acids-based-photodynamic-therapy-in-treating-squamous-cell-carcinoma
#7
Jianzhong Peng, Weiguo Feng, Xianyan Luo, Tao Wang, Wenzhong Xiang, Yeqin Dai, Jingyu Zhu, Junhui Zheng
BACKGROUND Squamous cell carcinoma (SCC) is the second most common type of skin cancer, for which non- or mini-invasive treatment is of critical importance. 5-aminolevulinic acids based photodynamic therapy (ALA-PDT) is a mini-invasive approach that causes focal tumor cell injury, apoptosis, and necrosis through light sensitivity. The efficacy of combining ALA-PDT and surgery in treating SCC, however, has not been demonstrated. MATERIAL AND METHODS A total of 60 SCC patients were randomly assigned into attrition plus ALA-PDT group (experimental group) and single ALA-PDT treatment group (control group)...
March 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28301624/photodynamic-therapy-effectively-treats-actinic-keratoses-without-pre-illumination-incubation-time
#8
Jessica Gandy, Brian Labadie, Dina Bierman, Christopher Zachary
<p>BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre-illumination incubation period and uses 2 back-to-back cycles of 16 minute 40 seconds.</p> <p>METHODS: The patient was prepped with soapy water and isopropyl alcohol, and thick AKs were descaled with a curette...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300722/effect-of-5-aminolevulinic-acid-photodynamic-therapy-on-keratinocyte-proliferation-and-apoptosis-in-condyloma-acuminatum
#9
Guangwen Yin, Ke Sha, Bingjie Cai, Fangfang Li, Xuyang Li, Xianxian Xia, Xinxin Pan
BACKGROUND: The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in condyloma acuminatum tissues was evaluated. METHODS: An immunohistochemical method and TdT-mediated dUTP nick end labeling were performed to detect the positive expression of the keratinocyte proliferation-related gene Ki-67 and apoptosis, respectively, in condyloma acuminatum tissues. RESULTS: Of 52 cases, 44 showed positive expression of Ki-67 in condyloma acuminatum keratinocytes before the treatment, with a positive expression rate of 84...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28296178/photosynthetic-bacterium-rhodopseudomonas-palustris-gj-22-induces-systemic-resistance-against-viruses
#10
Pin Su, Xinqiu Tan, Chenggang Li, Deyong Zhang, Ju'e Cheng, Songbai Zhang, Xuguo Zhou, Qingpin Yan, Jing Peng, Zhuo Zhang, Yong Liu, Xiangyang Lu
Photosynthetic bacteria (PSB) have been extensively used in agriculture to promote plant growth and to improve crop quality. Their potential application in plant disease management, however, is largely overlooked. In this study, the PSB strain Rhodopseudomonas palustris GJ-22 was investigated for its ability to induce resistance against a plant virus while promoting plant growth. In the field, a foliar spray of GJ-22 suspension protected tobacco plants against tobacco mosaic virus (TMV). Under axenic conditions, GJ-22 colonized the plant phyllosphere and induced resistance against TMV...
March 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28292933/complete-elucidation-of-the-late-steps-of-bafilomycin-biosynthesis-in-streptomyces-lohii
#11
Zhong Li, Lei Du, Wei Zhang, Xingwang Zhang, Yuanyuan Jiang, Kun Liu, Ping Men, Huifang Xu, Jeffrey L Fortman, David H Sherman, Bing Yu, Song Gao, Shengying Li
Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H+-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modification, prompting interests in improving bafilomycin activities via biosynthetic approaches. Two bafilomycin biosynthetic gene clusters have been identified, but their post- polyketide synthase (PKS) tailoring steps for structural diversification and bioactivity improvement remain largely unknown...
March 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28291213/-intraoperative-fluorescence-diagnosis-using-5-aminolevulinic-acid-in-surgical-treatment-of-children-with-recurrent-neuroepithelial-tumors
#12
A V Kim, V A Khachatryan
AIM: To analyze the efficacy and safety of 5-aminolevulinic acid for intraoperative fluorescence diagnosis (FD) during repeated surgery for recurrent neuroepithelial tumors (NETs) in children. MATERIAL AND METHODS: We performed a retrospective analysis of the results of recurrent NET resection in 13 children aged from 3 to 17 years in the period between December 2013 and May 2015. The source of 5-ALA was a drug "Alasens" that was administered at a dose of 20 mg/kg of body weight 4 h before the beginning of tumor resection...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28276005/the-role-of-photodynamic-therapy-in-acne-an-evidence-based-review
#13
REVIEW
Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
BACKGROUND: Acne vulgaris is a highly prevalent skin disorder that affects almost all adolescents and can persist into adulthood. Photodynamic therapy (PDT) is an emerging treatment for acne that involves the use of a photosensitizer in combination with a light source and oxygen. METHODS: We performed a systematic review of the literature and critically evaluated the studies. Sixty-nine clinical trials, four case reports, and two retrospective studies met the inclusion criteria, and seven of the studies were high quality...
March 8, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28265818/the-patients-view-impact-of-the-extent-of-resection-intraoperative-imaging-and-awake-surgery-on-health-related-quality-of-life-in-high-grade-glioma-patients-results-of-a-multicenter-cross-sectional-study
#14
Katrin Nickel, Mirjam Renovanz, Jochem König, Linda Stöckelmaier, Anne-Katrin Hickmann, Minou Nadji-Ohl, Jens Engelke, Elke Weimann, Dirk Freudenstein, Oliver Ganslandt, Lars Bullinger, Christian Rainer Wirtz, Jan Coburger
The objective of the present study is to assess the influence of extent of resection (EoR), use of intraoperative imaging, and awake surgery on health-related quality of life (HRQoL) in high-grade glioma (HGG) patients in a prospective multicenter study. We analyzed 170 surgeries of patients suffering from a HGG. During the first year after resection, HRQoL was evaluated using the European Organization of Research and Treatment of Cancer Core Questionnaire C30 and Brain Neoplasm 20 questionnaires. We assessed the influence of EoR; awake surgery; and use of 5-aminolevulinic acid (5-ALA), intraoperative MRI (iMRI), and their combination on sum scores for function and symptoms as well as several neurological single items...
March 6, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28257041/photodynamic-detection-of-peritoneal-metastases-using-5-aminolevulinic-acid-ala
#15
REVIEW
Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Akiyoshi Mizumoto, Masamitu Hirano, Yuuki Imazato, Nobuyuki Takao, Masumi Ichinose, Kousuke Noguchi, Yan Li, Satoshi Wakama, Kazuhiro Yamada, Koutarou Hatano, Hiroshi Shintani, Hiroyuki Yoshitake, Shun-Ichiro Ogura
In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction...
March 1, 2017: Cancers
https://www.readbyqxmd.com/read/28254552/assessment-of-in-vivo-experiments-the-newly-synthesized-porphyrin-with-proper-light-source-enhanced-effectiveness-of-pdt-comparing-to-5-ala
#16
Kamil Jurczyszyn, Marta Woźniak, Krzysztof Symonowicz, Natasza Sprutta, Lechosław Latos-Grażyński, Piotr Ziółkowski, Yurij Ivonyak, Piotr Tuchowski, Witold Trzeciakowski
BACKGROUND: The search for new photosensitizers for application in photodynamic therapy has quite a long history. In the past, a large number of potent photosensitizers were used in both basic and clinical studies; however, only a few turned out to be effective and safe. METHODS: In the present study, two compounds were used: 5-aminolevulinic acid in two formulations (free and liposomal), and the newly synthesized porphyrin, 5,10,15,20-tetra-p-tolyl-22,24-dithiadibenzocarbaporphyrin, termed DTDB...
February 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28247741/-a-systematic-review-and-meta-analysis-to-assess-the-recurrence-free-survival-in-non-muscle-invasive-bladder-cancer-after-transurethral-resection-guided-by-5-aminolevulinic-acid-induced-photodynamic-diagnosis-compared-with-white-light-transurethral-resect
#17
A I Rolevich, A A Evmenenko
INTRODUCTION: We conducted a meta-analysis assessing the effect of photodynamic diagnosis (PDD) -guided transurethral resection of the bladder tumor (TURB) on the recurrence-free survival in patients with non-muscle invasive bladder cancer within prospective randomised trials that used 5-aminolevulinic acid as a photosensitizer. MATHERIAL AND METHODS: Medical literature search was performed up to February 2016. Recurrence hazard ratios (HRs) and its 95% confidence intervals (CI) were calculated for each selected study with direct and indirect methods and the pooled estimates were obtained with random-effects model...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28223144/combination-of-hand-held-probe-and-microscopy-for-fluorescence-guided-surgery-in-the-brain-tumor-marginal-zone
#18
Johan Richter, Neda Haj-Hosseini, Martin Hallbeck, Karin Wårdell
BACKGROUND: Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-micsorcope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. METHODS: Eighteen operations were performed on 16 patients with suspected high-grade glioma...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28214935/promotive-role-of-5-aminolevulinic-acid-on-chromium-induced-morphological-photosynthetic-and-oxidative-changes-in-cauliflower-brassica-oleracea-botrytis-l
#19
Rehan Ahmad, Shafaqat Ali, Fakhir Hannan, Muhammad Rizwan, Muhammad Iqbal, Zaidul Hassan, Nudrat Aisha Akram, Saliha Maqbool, Farhat Abbas
Chromium (Cr) is among the most toxic pollutants in the environment that adversely affect the living organisms and physiological processes in different plants. The present study investigated the effect of 15 mg L(-1) of 5-aminolevulinic acid (ALA) on morpho-physiological attributes of cauliflower (Brassica oleracea botrytis L.) under different Cr concentrations (0, 10, 100, and 200 μM) in the growth medium. The results showed that Cr stress decreased the growth, biomass, photosynthetic, and gas exchange parameters...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28204539/histopathological-insights-on-imaging-results-of-intraoperative-magnetic-resonance-imaging-5-aminolevulinic-acid-and-intraoperative-ultrasound-in-glioblastoma-surgery
#20
Jan Coburger, Angelika Scheuerle, Andrej Pala, Dietmar Thal, Christian Rainer Wirtz, Ralph König
No abstract text is available yet for this article.
February 14, 2017: Neurosurgery
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