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Ewings sarcoma of the pelvis

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https://www.readbyqxmd.com/read/28244685/pelvis-ewing-sarcoma-local-control-and-survival-in-the-modern-era
#1
Safia K Ahmed, Steven I Robinson, Carola A S Arndt, Ivy A Petersen, Michael G Haddock, Peter S Rose, Nadia N Issa Laack
PURPOSE: Local control for Ewing sarcoma (ES) has improved in modern studies. However, it is unclear if these gains have also been achieved for pelvis tumors. The purpose of this study is to evaluate local control and survival in pelvis ES patients treated in the modern era. METHODS: All pelvis ES patients diagnosed from 1990 to 2012 and seen at Mayo Clinic were identified. Factors relevant to survival and local control were analyzed. RESULTS: The cohort consisted of 48 patients...
February 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28122109/extraosseous-ewing-sarcoma-expanding-the-differential-diagnosis-of-supraclavicular-fossa-tumors
#2
Julio Rama-López, Rafael Ramos Asensio, Cesar García-Garza, Pablo Luna Fra, Maria Del Carmen Gassent Balaguer, José Fuster Salva
A broad spectrum of diseases can be included in the differential diagnosis of neck masses. We report a case of extraosseous Ewing sarcoma that presented as a neck mass in a 70-year-old man. To the best of our knowledge, this is the first reported case of extraosseous Ewing sarcoma of the supraclavicular fossa. Published cases of extraosseous Ewing sarcoma in the neck have been described in other age groups, but those tumors were confined to the parapharyngeal space. Also, there have been reported cases in patients older than 70 years in which Ewing sarcoma affected other structures such as the larynx and the pelvis, but none in the soft tissues of the neck...
January 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27774356/ewing-sarcoma-of-the-pelvis-with-an-atypical-radiographic-appearance-a-mimicker-of-non-malignant-etiologies
#3
Miguel Flores, Anthony Caram, Edward Derrick, John D Reith, Laura Bancroft, Kurt Scherer
Ewing sarcoma (ES) is a primary malignant bone tumor which most commonly arises in children and young adults. The common clinical presentation with ES includes nighttime pain or pain related to activity, though patients may also present with a combination of localized swelling, a palpable mass, pathologic fracture, and constitutional symptoms. Clinical diagnosis may be delayed when a patient presents with clinical or imaging findings that overlap with non-malignant etiologies, such as fibrous dysplasia (FD) or osteomyelitis...
September 18, 2016: Curēus
https://www.readbyqxmd.com/read/27696963/rare-extraskeletal-ewing-s-sarcoma-mimicking-as-adenocarcinoma-of-the-sigmoid
#4
Michelle Mertens, Filip W N Haenen, Vasiliki Siozopoulou, Marc Van Cleemput
INTRODUCTION: Extraskeletal Ewing's sarcoma (EES) is a rare finding in comparison with Ewing's sarcoma of bone and usually manifests in young patients. However, even in older patients, one must consider the diagnosis. PATIENTS AND METHODS: In this case, we describe a 52-year-old woman diagnosed with EES, mimicking as adenocarcinoma of the sigmoid. RESULTS: The tumor was not visualized by a multi-slice spiral computed tomography of the abdomen and pelvis with intravenous contrast, and eventually the diagnosis was made by positive immunohistochemical staining for CD99 and by molecular testing for EWSR1 translocation...
October 4, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27603186/outcome-of-pelvic-bone-sarcomas-in-children
#5
Minna Laitinen, Michael Parry, Jose I Albergo, Lee Jeys, Vaiyapuri Sumathi, Robert Grimer
BACKGROUND: Malignant bone tumors of the pelvis in children are rare and knowledge of their behavior is limited. METHODS: A total of 113 skeletally immature patients under 16 years of age, comprising 58 females and 55 males were treated between 1983 and 2014. Tumors comprised Ewing's sarcoma (ES) in 88 (77.9%) or osteosarcoma (OS) in 25 (22.1%). Metastases at diagnosis were present in 36 (31.9%). The mean follow-up was 5.2 years (2 to 16). RESULTS: For patients with ES, the overall survival was 37...
September 3, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27464543/-clinical-pathological-and-imaging-features-of-primary-pelvic-ewing-s-sarcoma
#6
J Liu, Y Chen, X L Ling, Y Gong, J P Ding, Z K Zhang, Y J Wang
OBJECTIVE: To explore the clinical, pathological and imaging features of Ewing's sarcoma in pelvis and to improve knowledge and diagnosis of the disease. METHODS: A retrospective analysis of the clinical, pathological and imaging data of pathologically confirmed 13 cases of Ewing's sarcoma in pelvis was carried out between May 2008 and March 2016 in the Affiliated Hospital of Hangzhou Normal University, the Third Hospital of Hebei Medical University and the Second Hospital of Hebei Medical University...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27228320/bcor-ccnb3-positive-soft-tissue-sarcoma-with-round-cell-and-spindle-cell-histology-a-series-of-four-cases-highlighting-the-pitfall-of-mimicking-poorly-differentiated-synovial-sarcoma
#7
Wan-Shan Li, I-Chuang Liao, Mei-Chin Wen, Howard Haw-Chang Lan, Shih-Chen Yu, Hsuan-Ying Huang
AIMS: BCOR-CCNB3 sarcoma is a genetically defined undifferentiated malignancy with Ewing sarcoma (ES)-like round cells, and preferentially affects the bones of male adolescents. Sarcomas harbouring BCOR-CCNB3 rarely arise from soft tissues; therefore, we aimed to report four cases to expand the clinicopathological spectrum. METHODS AND RESULTS: By reverse transcription polymerase chain reaction and confirmatory sequencing, we detected a BCOR-CCNB3 transcript in primary undifferentiated sarcomas of the deep musculature of four male patients, comprising two teenagers (aged 14 and 17 years) and two adults (aged 34 and 44 years)...
November 2016: Histopathology
https://www.readbyqxmd.com/read/27190820/blue-cell-tumour-at-unusual-site-retropritoneal-ewings-sarcoma
#8
Anita P Javalgi, Mahesh H Karigoudar, Katyayani Palur
Ewing's sarcoma is a highly malignant tumour of osseous or non-osseous origin, tremed as extra-skeletal Ewings sarcoma if arising from soft tissue. It is rare occurrence tumor most commonly occurring in paravertebral area, chest wall, head & neck and retroperitoneum. Reporting an interesting case of retroperitoneal Ewing's sarcoma in 39 years old female. Patient had complains of abdominal discomfort & vague pain since 2 months, following weakness in lower limb and loss of weight. On detail history and examination she was further referred to detail pathological and radiological investigations...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26917407/the-role-of-radiotherapy-in-local-control-of-nonextremity-ewing-sarcomas
#9
Ozlem O Akagunduz, Serra A Kamer, Burcin Kececi, Bengu Demirag, Haldun Oniz, Mehmet Kantar, Nazan Cetingul, Dundar Sabah, Yavuz Anacak
PURPOSE: To evaluate the results of radiotherapy and the prognostic factors affecting local control in nonextremity Ewing sarcomas. METHODS: Between 1995 and 2011, 44 patients with nonextremity Ewing sarcomas were treated with radiotherapy. Tumor localizations were pelvis in 23, spine in 13, thoracic region in 5, and cranium in 3 patients. Tumor size was ≥8 cm in 56.8% of patients. Distant metastases were present in 19 of the patients at the time of diagnosis (43...
March 2016: Tumori
https://www.readbyqxmd.com/read/26842410/improved-prognosis-for-patients-with-ewing-sarcoma-in-the-sacrum-compared-with-the-innominate-bones-the-scandinavian-sarcoma-group-experience
#10
COMPARATIVE STUDY
Asle Charles Hesla, Panagiotis Tsagozis, Nina Jebsen, Olga Zaikova, Henrik Bauer, Otte Brosjö
BACKGROUND: Treatment of Ewing sarcoma of the pelvic bones remains one of the most difficult tasks in the treatment of bone sarcomas. Whether surgery or radiation therapy is the best local treatment is still a matter of debate. The aim of the present study was to compare sacral and nonsacral sites with regard to the treatment and outcome of pelvic Ewing sarcomas. METHODS: Patients with Ewing sarcoma of the osseous pelvis diagnosed between 1986 and 2011 were identified through the Scandinavian Sarcoma Group registry...
February 3, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/26795741/ewing-s-sarcoma-of-the-pelvis-an-unusual-but-not-to-be-missed-cause-of-an-irritable-hip
#11
Partha Ray, Julekha Girach, Anish Pradip Sanghrajka
A 15-year-old girl presented with a 2-month history of non-specific right hip pain associated with pain in the back, right flank and foot. Her symptoms deteriorated, interfering with weight-bearing. Following admission, she was found to be febrile with a flexion deformity of her right-hip, and tenderness over the iliac crest and posterior pelvis. A markedly elevated C reactive protein and erythrocyte sedimentation rate, with an ultrasound-proven scan effusion within the right hip were all suggestive of septic arthritis...
January 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26299743/-extraoseus-ewings-sarcoma-primary-affection-of-uterine-cervix-case-report
#12
O Bílek, M Holánek, M Zvaríková, P Fabian, B Robešová, M Procházková, D Adámková Krákorová
BACKGROUND: Ewing's sarcoma is usually diagnosed in adolescents and young adults, peak of incidence is around 15 years of age. Primary localization is mostly in the skeleton of long bones and chest wall. Primary extraosseous involvement rarely occurs, incidence increases with age. CASE: We present a case report of a 57-year-old patient with locally advanced tumors of the cervix, clinical stage IIB. Due to histological and molecular genetic examination revealing EWS -ERG fusion gene, Ewing's sarcoma was diagnosed...
2015: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/26278018/routes-to-diagnosis-for-sarcoma-describing-the-sarcoma-patient-journey
#13
C Gerrand, M Francis, N Dennis, J Charman, G Lawrence, T Evans, R Grimer
BACKGROUND: Understanding the route to diagnosis for patients with cancer is important to improve the diagnostic pathway and therefore outcomes. We aimed to investigate routes to diagnosis for patients with sarcoma in England. METHODS: National patient level datasets relating to 7716 soft tissue and 1240 bone sarcoma patients diagnosed between 2006 and 2008 were analysed. Routes to diagnosis were defined as: "Two Week Wait Referral", "GP Referral", "Other Outpatient", "Inpatient Elective", "Emergency Presentation", "Death Certificate Only" and "Unknown"...
October 2015: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26175577/imaging-features-of-primary-tumors-and-metastatic-patterns-of-the-extraskeletal-ewing-sarcoma-family-of-tumors-in-adults-a-17-year-experience-at-a-single-institution
#14
Jimi Huh, Kyung Won Kim, Seong Joon Park, Hyoung Jung Kim, Jong Seok Lee, Hyun Kwon Ha, Sree Harsha Tirumani, Nikhil H Ramaiya
OBJECTIVE: To comprehensively analyze the spectrum of imaging features of the primary tumors and metastatic patterns of the Extraskeletal Ewing sarcoma family of tumors (EES) in adults. MATERIALS AND METHODS: We performed a computerized search of our hospital's data-warehouse from 1996 to 2013 using codes for Ewing sarcoma and primitive neuroectodermal tumors as well as the demographic code for ≥ 18 years of age. We selected subjects who were histologically confirmed to have Ewing sarcoma of extraskeletal origin...
July 2015: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/26152121/spinal-intradural-metastasis-from-scapular-ewing-sarcoma
#15
Dissanayake Mudiyanselage Priyantha Udaya Kumara Ralapanawa, Kushalee Poornima Jayawickreme, Ekanayake Mudiyanselage Madhushanka Ekanayake, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini Kumarihamy
BACKGROUND: Ewing sarcoma is a primary bone neoplasm, which is a high grade aggressive small round blue cell tumour, and is currently recognized as a part of the Ewing family of tumours. It is the most lethal bone tumor, and is a rare malignant bone tumor accounting for 10% of all primary bone tumors, and 6% of malignant bone tumors. It has an average annual incidence of 3 per 1 million, found almost exclusively in Caucasians. It commonly occurs in long bones and pelvis but rarely involves the scapula...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/26136562/primary-orbital-ewing-s-sarcoma-presenting-with-local-recurrence-to-maxillary-sinus-shortly-after-tumor-resection
#16
Selam Yekta Sendul, Cemile Ucgul, Fevziye Kabukcuoglu, Burcu Dirim, Dilek Guven
Ewing's sarcoma (ES) is a malignant, small-round-cell neoplasm that normally affects the long bones of the limbs or the pelvis. Primary orbital ES of the skull has been considered extremely rare. We describe the case of a 19-year-old female patient with primary ES originating from the inferior orbital rime and, shortly after tumor resection, local recurrence to the maxillary sinus.
2015: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/26135561/smarca4-brg1-loss-of-expression-is-a-useful-marker-for-the-diagnosis-of-ovarian-small-cell-carcinoma-of-the-hypercalcemic-type-ovarian-rhabdoid-tumor-a-comprehensive-analysis-of-116-rare-gynecologic-tumors-9-soft-tissue-tumors-and-9-melanomas
#17
COMPARATIVE STUDY
Marie Karanian-Philippe, Valérie Velasco, Michel Longy, Anne Floquet, Laurent Arnould, Jean-Michel Coindre, Cécile Le Naoures-Méar, Gerlinde Averous, Frédéric Guyon, Gaëtan MacGrogan, Sabrina Croce
Ovarian small cell carcinoma of the hypercalcemic type (SCCOHT)/ovarian rhabdoid tumor is a rare and highly malignant tumor that typically occurs in young women. Up until now the diagnosis has been made on the basis of morphology without any specific immunohistochemical (IHC) markers. However, several authors have shown recently that SCCOHTs are characterized by inactivation of the SMARCA4 gene (encoding the BRG1 protein) resulting in a loss of BRG1 protein expression in IHC. We evaluated BRG1 and INI1 expression in 12 SCCOHTs and in a series of 122 tumors that could mimic SCCOHT morphologically: 9 juvenile granulosa cell tumors, 47 adult granulosa cell tumors, 33 high-grade ovarian serous carcinomas, 9 desmoplastic round cell tumors, 13 Ewing sarcomas (5 from the pelvis and 8 from soft tissues), 1 round cell sarcoma associated with CIC-DUX4 translocation from soft tissue (thigh), 1 case of high-grade endometrial stromal sarcoma of the ovary, and 9 melanomas...
September 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25993237/chemotherapy-for-bone-sarcomas-in-adults-the-md-anderson-experience
#18
REVIEW
Robert S Benjamin, Michael J Wagner, J Andrew Livingston, Vinod Ravi, Shreyaskumar R Patel
Increasing age is an adverse prognostic factor in the treatment of primary bone tumors. There are few published data on treatment of primary bone tumors in adults. This paper presents data from the Department of Sarcoma Medical Oncology at The University of Texas MD Anderson Cancer Center, summarizing our treatment results. To treat primary osteosarcoma, we used 90 mg/m2 of doxorubicin as a continuous intravenous infusion over 48 to 96 hours and 120 to 160 mg/m2 of cisplatin intravenously or intra-arterially...
2015: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/25599318/long-term-outcomes-and-complications-in-pediatric-ewing-sarcoma
#19
Sarah N Hamilton, Ryan Carlson, Haroon Hasan, Shahrad R Rassekh, Karen Goddard
OBJECTIVES: The objective of this study was to determine treatment outcomes and long-term complications in pediatric patients with Ewing Sarcoma treated at the British Columbia Cancer Agency (BCCA). METHODS: A retrospective chart review of 101 pediatric patients (<19 y old) with Ewing Sarcoma diagnosed between 1960 and 2005 was performed. The Kaplan-Meier survival analysis and Cox regression multivariate analysis were used to assess prognostic factors for overall survival (OS) and event-free survival (EFS)...
January 16, 2015: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25573215/-reimplantation-of-devitalized-tumor-bearing-bone-in-pelvic-reconstruction-after-en-bloc-tumor-resection
#20
Yi Yang, Wei Guo, Rongli Yang, Xiaodong Tang, Taiqiang Yan, Tao Ji, Ran Wei
OBJECTIVE: To analyze the clinical outcome of an operative technique using recycling bones to reconstruct pelvis after primary malignant pelvic tumor resection. METHODS: Fifteen patients who presented with malignant pelvic tumors were treated by wide or marginal resection and reconstruction using recycling bone in our institute from January 2003 to December 2011. The median age was 31 (15-62) years, and the most common diagnosis was chondrosarcoma, followed by Ewing sarcoma...
October 2014: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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