keyword
MENU ▼
Read by QxMD icon Read
search

Protoporphyrin ix

keyword
https://www.readbyqxmd.com/read/28432590/pathological-analysis-of-the-surgical-margins-of-resected-glioblastomas-excised-using-photodynamic-visualization-with-both-5-aminolevulinic-acid-and-fluorescein-sodium
#1
Hirohito Yano, Noriyuki Nakayama, Naoyuki Ohe, Kazuhiro Miwa, Jun Shinoda, Toru Iwama
During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous double staining with 5-ALA and Fl-Na during surgery. Eight patients received 5-ALA (20 mg/kg orally) before the induction of general anesthesia, and Fl-Na (20 mg/kg) was administered intravenously before the dural incision was performed...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28431098/egg-production-and-egg-quality-in-free-range-laying-hens-housed-at-different-outdoor-stocking-densities1
#2
D L M Campbell, C Lee, G N Hinch, J R Roberts
Free-range laying hen systems are increasing in number within Australia. Variation in outdoor stocking densities has led to development of a national information standard on free-range egg labeling, including setting a maximum density of 10,000 hens per hectare. However, there are few data on the impacts of differing outdoor densities on production and egg quality. ISA Brown hens in small (150 hens) flocks were housed in identical indoor pens, each with access (from 21 weeks) to different sized ranges simulating one of three outdoor stocking densities (2 replicates each: 2,000 hens/hectare (ha), 10,000 hens/ha, 20,000 hens/ha)...
April 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28426936/cholesterol-assisted-bacterial-cell-surface-engineering-for-photodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria
#3
Hao-Ran Jia, Ya-Xuan Zhu, Zhan Chen, Fu-Gen Wu
Antibacterial photodynamic therapy (PDT) which enables effective killing of regular and multidrug-resistant (MDR) bacteria is a promising treatment modality for bacterial infection. However, because most photosensitizer (PS) molecules fail to strongly interact with the surface of Gram-negative bacteria, this technique is only suitable for treating Gram-positive bacterial infection, which largely hampers its practical applications. Herein, we revealed for the first time that cholesterol could significantly facilitate the hydrophobic binding of PSs to the bacterial surface, achieving the hydrophobic interaction-based bacterial cell surface engineering that could effectively photo-inactivate both Gram-negative and Gram-positive bacteria...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422996/overexpression-of-an-eazip-gene-devoid-of-transit-peptide-sequence-induced-leaf-variegation-in-tobacco
#4
Xiayu Guan, Zhijian Li, Zhiliang Zhang, Xiangying Wei, Jiahua Xie, Jianjun Chen, Qingxi Chen
Leaf variegation is an ornamental trait that is not only biologically but also economically important. In our previous study, a Mg-protoporphyrin IX monomethyl ester cyclase homologue, EaZIP (Epipremnum aureum leucine zipper) was found to be associated with leaf variegation in Epipremnum aureum (Linden & Andre) G.S. Bunting. The protein product of this nuclear-encoded gene is targeted back to chloroplast involving in chlorophyll biosynthesis. Based on a web-based homology analysis, the EaZIP was found to lack a chloroplast transit peptide (cTP) sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28420988/heme-as-a-target-for-therapeutic-interventions
#5
REVIEW
Stephan Immenschuh, Vijith Vijayan, Sabina Janciauskiene, Faikah Gueler
Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and myoglobin, which are crucial for reversible oxygen binding and transport. By contrast, high levels of free heme, which may occur in various pathophysiological conditions, are toxic via pro-oxidant, pro-inflammatory and cytotoxic effects. The toxicity of heme plays a major role for the pathogenesis of prototypical hemolytic disorders including sickle cell disease and malaria...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28418534/optical-sectioning-microscopy-of-protoporphyrin-ix-fluorescence-in-human-gliomas-standardization-and-quantitative-comparison-with-histology
#6
Linpeng Wei, Ye Chen, Chengbo Yin, Sabine Borwege, Nader Sanai, Jonathan T C Liu
No abstract text is available yet for this article.
April 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28416355/expression-of-coproporphyrinogen-oxidase-is-associated-with-detection-of-upper-gastrointestinal-carcinomas-by-5-aminolevulinic-acid-mediated-photodynamic-diagnosis
#7
Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao
BACKGROUND: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer...
April 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28412459/no-changes-in-heme-synthesis-in-human-friedreich%C3%A2-s-ataxia-erythroid-progenitor-cells
#8
Hannes Steinkellner, Himanshu Narayan Singh, Martina U Muckenthaler, Hans Goldenberg, Rajeswari R Moganty, Barbara Scheiber-Mojdehkar, Brigitte Sturm
Friedreich's ataxia (FRDA) is a neurodegenerative disease caused by reduced expression of the protein frataxin. Frataxin is thought to play a role in iron-sulfur cluster biogenesis and heme synthesis. In this study, we used erythroid progenitor stem cells obtained from FRDA patients and healthy donors to investigate the putative role, if any, of frataxin deficiency in heme synthesis. We used electrochemiluminescence and qRT-PCR for frataxin protein and mRNA quantification. We used atomic absorption spectrophotometry for iron levels and a photometric assay for hemoglobin levels...
April 12, 2017: Gene
https://www.readbyqxmd.com/read/28402952/caveolin-1-scaffolding-domain-peptides-enhance-anti-inflammatory-effect-of-heme-oxygenase-1-through-interrupting-its-interact-with-caveolin-1
#9
Ping Weng, Xiao-Tong Zhang, Qiong Sheng, Wen-Fang Tian, Jun-Liang Chen, Jia-Jia Yuan, Ji-Ru Zhang, Qing-Feng Pang
Caveolin-1(Cav-1) scaffolding domain (CSD) peptides compete with the plasma membrane Cav-1, inhibit the interaction of the proteins and Cav-1, and re-store the functions of Cav-1 binding proteins. Heme oxygenase-1 (HO-1) binds to Cav-1 and its enzymatic activity was inhibited. In this study, we investigated the effect of CSD peptides on interaction between HO-1 and Cav-1, and on the HO-1 activity in vitro and in vivo. Our data showed that CSD peptides decreased the compartmentalization of HO-1 and Cav-1, and increased the HO-1 activity both in LPS-treated alveolar macrophages and in mice...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28397487/design-and-proof-of-programmed-5-aminolevulinic-acid-prodrug-nanocarriers-for-targeted-photodynamic-cancer-therapy
#10
Jina Wu, Haijie Han, Qiao Jin, Zuhong Li, Huan Li, Jian Ji
5-Aminolevulinic acid (ALA), the precursor of photosensitizer protoporphyrin IX (PpIX), is a U.S. FDA-approved photodynamic therapeutic agent. However, realizing efficient delivery of ALA is still a big challenge as it is hydrophilic and cannot be recognized and selectively accumulated in tumor cells. In this study, matrix metalloproteinase-2 (MMP-2) and pH dual-sensitive ALA prodrug nanocarriers were constructed as a programmed delivery strategy for the targeted delivery of ALA. The nanocarriers were prepared by the co-modification of gold nanoparticles (AuNPs) with hydrazone-linked ALA and MMP-2-activatable cell-penetrating peptides (CPPs)...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28393189/upregulation-of-heme-oxygenase-1-in-kupffer-cells-blocks-mast-cell-degranulation-and-inhibits-dendritic-cell-migration-in%C3%A2-vitro
#11
Yuan-Yuan Ma, Mu-Qing Yang, Zhi-Gang He, Mao-Hong Fan, Man Huang, Fei Teng, Qing Wei, Ji-Yu Li
Kupffer cells (KCs) influence liver allografts by interacting with other non‑parenchymal cells. However, the exact mechanism remains unclear. Upregulation of heme oxygenase-1 (HO-1) in KCs upon interaction with mast cells (MCs), and the effects on dendritic cell (DC) function, were investigated in the present study. KCs, MCs and DCs were prepared from 8‑10‑week‑old C57BL/6 mice. KCs were pretreated with PBS, dimethyl sulfoxide, hemin (50 µM; HO‑1 inducer), and zinc protoporphyrin (50 µM; HO‑1 inhibitor) for 8 h...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28386340/lipoxin-a4-pretreatment-mitigates-skeletal-muscle-ischemia-reperfusion-injury-in-rats
#12
Haiyang Zong, Xinghui Li, Haodong Lin, Chunlin Hou, Fenfen Ma
The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery followed by 3 h of reperfusion. Treatment with LA4 significantly ameliorated histological damage scores in I/R-injured skeletal muscle. LA4 treatment resulted in remarkable decreases in the wet weight/dry weight ratio (W/D ratio), inflammatory response, oxidative stress, and cell apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28386327/reduction-of-cox-2-through-modulating-mir-124-sphk1-axis-contributes-to-the-antimetastatic-effect-of-alpinumisoflavone-in-melanoma
#13
Ming Gao, Yuan Chang, Xiuyong Wang, Chao Ban, Fan Zhang
Alpinumisoflavone (AIF) is a naturally occurring flavonoid that is a major bioactive component of the medicinal plant Derris eriocarpa. In this study we evaluated the antimetastatic effect of AIF and investigated the underlying mechanism of action using in vitro and in vivo models of melanoma. We found that AIF impaired the metastatic potential of A375 and SK-MEL-1 human melanoma cells by promoting cell differentiation as assessed by melanin content, protoporphyrin IX accumulation, and tissue transglutaminase activity...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28379547/randomized-prospective-double-blinded-study-comparing-3-different-doses-of-5-aminolevulinic-acid-for-fluorescence-guided-resections-of-malignant-gliomas
#14
Walter Stummer, Herbert Stepp, Otmar D Wiestler, Uwe Pichlmeier
BACKGROUND: Five-aminolevulinic acid (5-ALA) is used for fluorescence-guided resections of malignant glioma at a dose of 20 mg/kg; yet, it is unknown whether lower doses may also provide efficacy. OBJECTIVE: To perform a double-blinded randomized study comparing 3 different doses of 5-ALA. METHODS: Twenty-one patients with suspected malignant glioma were randomly assigned to 0.2, 2, or 20 mg/kg 5-ALA. Investigators were unaware of dose. Intraoperatively, regions of interest were first defined in tumor core, margin, and adjacent white matter under white light...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28373434/photodynamic-therapy-mediated-by-a-novel-chlorin-derivative-tons-501-na-in-emt6-cells
#15
Tomohiro Osaki, Isao Sakata, Yoshihiro Uto, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Itoh, Tomohiro Imagawa, Yoshiharu Okamoto
BACKGROUND: The lipophilic photosensitizer, TONS 501, is a novel porphyrin-derived methyl ester that was developed for photodynamic antimicrobial chemotherapy. This study developed a hydrophilic and anionic porphyrin salt of this compound (TONS 501-Na) for use in photodynamic therapy (PDT). This chlorin derivative is synthesized from the protoporphyrin IX dimethyl ester. MATERIALS AND METHODS: We investigated the in vitro cytotoxic effects of TONS 501-Na-mediated PDT on EMT6 mouse breast cancer cells...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28368519/overexpression-of-ho-1-contributes-to-sepsis-induced-immunosuppression-by-modulating-the-th1-th2-balance-and-regulatory-t-cell-function
#16
Seong-Jin Yoon, So-Jin Kim, Sun-Mee Lee
Background.: Countervailing anti-inflammatory response and immunosuppression can cause death in late sepsis. Depletion and dysfunction of T-cells are critical for developing sepsis-induced immunosuppression. Heme oxygenase (HO)-1 has a regulatory effect on differentiation and function of T-cells and anti-inflammatory properties. We therefore investigated the immunosuppressive role of HO-1 in sepsis with a focus on its effects on helper T-cell (Th) differentiation and regulatory T-cells (Treg)...
March 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28363026/hydroxypyridinone-and-5-aminolaevulinic-acid-conjugates-for-photodynamic-therapy
#17
Sinan Battah, Robert C Hider, Alexander J MacRobert, Paul S Dobbin, Tao Zhou
Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions. 5-Aminolaevulinic acid (ALA) is used as a precursor of the photosensitizer, protoporphyrin IX (PpIX), in dermatology and urology. However, the effectiveness of ALA-PDT is limited by the relatively poor bioavailability of ALA and rapid conversion of PpIX to haem. The main goal of this study was to prepare and investigate a library of single conjugates designed to coadminister the bioactive agents ALA and hydroxypyridinone (HPO) iron chelators...
April 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28362081/photosensitized-h2-production-using-a-zinc-porphyrin-substituted-protein-platinum-nanoparticles-and-ascorbate-with-no-electron-relay-participation-of-good-s-buffers
#18
Emily R Clark, Donald M Kurtz
Development of efficient light-driven splitting of water, 2H2O → 2H2 + O2, often attempts to optimize photosensitization of the reductive and oxidative half-reactions individually. Numerous homogeneous and heterogeneous systems have been developed for photochemical stimulation of the reductive half reaction, 2H(+) + 2e(-) → H2. These systems generally consist of various combinations of a H(+) reduction catalyst, a photosensitizer (PS), and a "sacrificial" electron donor. Zinc(II)-porphyrins (ZnPs) have frequently been used as PSs for H2 generation, but they are subject to various self-quenching processes in aqueous solutions...
March 31, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28361427/age-specific-characteristics-of-co-mediated-reaction-of-the-pial-arteries-of-various-diameters-in-rats
#19
A E Kotsyuba, V M Chertok, A G Chertok
First-fourth order pial branches of the median cerebral artery were studied by biomicroscopy in male Wistar rats aged 1 and 12 months. Irrespective of age, CO-mediated mechanisms are involved in the regulation of the basal tone of pial vessels of various diameters (more so of arteries with well-developed muscular tunic). Injection of hemin confirmed that endogenous production of CO maintained vasodilatation and this effect was most pronounced in large pial branches of young animals, while zinc protoporphyrin IX blocked this effect in all cases...
March 31, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28348154/mechanisms-of-vesicular-stomatitis-virus-inactivation-by-protoporphyrin-ix-zinc-protoporphyrin-ix-and-mesoporphyrin-ix
#20
Christine Cruz-Oliveira, Andreza F Almeida, João M Freire, Marjolly B Caruso, Maria A Morando, Vivian N S Ferreira, Iranaia Assunção-Miranda, Andre M O Gomes, Miguel A R B Castanho, Andrea T Da Poian
Virus resistance to antiviral therapies is an increasing concern that makes urgent the development of broad spectrum antiviral drugs. Targeting viral envelope, a component shared by a large number of viruses, emerges as a promising strategy to overcome this problem. Natural and synthetic porphyrins, due to their relative hydrophobicity and pro-oxidant character, are good candidates for antivirals' development. In the present work, we characterized the antiviral activity of protoprophyrin IX (PPIX), Zn-protoporphyrin IX (ZnPPIX) and mesoporphyrin IX (MPIX) against vesicular stomatitis virus (VSV), and evaluated the mechanisms involved in this activity...
March 27, 2017: Antimicrobial Agents and Chemotherapy
keyword
keyword
5041
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"