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Protoporphyrin ix

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https://www.readbyqxmd.com/read/28935534/neurosurgical-microscopic-solid-laser-based-light-inhibits-photobleaching-during-fluorescence-guided-brain-tumor-removal-with-5-aminolevulinic-acid
#1
Fumitaka Matsuda, Naokado Ikeda, Yoshinaga Kajimoto, Naosuke Nonoguchi, Koji Takeuchi, Masao Fukumura, Shinji Kawabata, Motomasa Furuse, Tetsuo Sugano, Taku Sato, Kiyoshi Saito, Toshihiko Kuroiwa
BACKGROUND: Fluorescence image guided surgery (FIGS) with 5-aminolevulinic acid for malignant gliomas improves surgical outcome. One of the problems during FIGS is photobleaching under surgical microscopic white light. A solid laser-based white light source for neurosurgery that we developed does not include light with a wavelength of around 405nm, which is strongly absorbed by protoporphyrin IX. In the present study, we examined the efficacy of this light source to prevent the photobleaching of protoporphyrin IX-induced fluorescence...
September 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28933502/synthesis-and-evaluation-of-new-5-aminolevulinic-acid-derivatives-as-prodrugs-of-protoporphyrin-for-photodynamic-therapy
#2
Wei Zhu, Ying-Hua Gao, Chun-Hong Song, Zhi-Bin Lu, Tabbisa Namulinda, Yi-Ping Han, Yi-Jia Yan, Lai-Xing Wang, Zhi-Long Chen
Protoporphyrin IX (PpIX) is used as a photosensitizer in the photodynamic diagnosis (PDD) and photodynamic therapy (PDT) of cancer and is synthesized intracellularly from 5-aminolevulinic acid (5-ALA) precursors. Thirteen novel 5-ALA derivatives were designed and synthesized appropriately with tailored hydrophilicity and lipophilicity. The generation of PpIX was detected and their antitumor activity in vitro and in vivo was also investigated. It was shown that compounds 9b-c, 11b-c and 13a displayed a characteristic long wavelength absorption peak at 593 nm after 5 h incubation in mice fibrosarcoma S180 cells...
September 21, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28926633/effects-of-salinity-on-the-cellular-physiological-responses-of-natrinema-sp-j7-2
#3
Yunjun Mei, Huan Liu, Shunxi Zhang, Ming Yang, Chun Hu, Jian Zhang, Ping Shen, Xiangdong Chen
The halophilic archaea (haloarchaea) live in hyersaline environments such as salt lakes, salt ponds and marine salterns. To cope with the salt stress conditions, haloarchaea have developed two fundamentally different strategies: the "salt-in" strategy and the "compatible-solute" strategy. Although investigation of the molecular mechanisms underlying the tolerance to high salt concentrations has made outstanding achievements, experimental study from the aspect of transcription is rare. In the present study, we monitored cellular physiology of Natrinema sp...
2017: PloS One
https://www.readbyqxmd.com/read/28889035/influence-of-meat-source-ph-and-production-time-on-zinc-protoporphyrin-ix-formation-as-natural-colouring-agent-in-nitrite-free-dry-fermented-sausages
#4
Hannelore De Maere, Sylvie Chollet, Jos De Brabanter, Chris Michiels, Hubert Paelinck, Ilse Fraeye
Nitrite is commonly used in meat products due to its plural technological advantages. However, it is controversial because of its detrimental side effects on health. Within the context of nitrite reduction, zinc protoporphyrin IX (Zn(II)PPIX) formation in meat products as natural red colouring agent has been suggested. This investigation presents the evaluation of naturally occurring pigments, namely Zn(II)PPIX, protoporphyrin IX (PPIX) and heme in nitrite-free dry fermented sausages in function of time, meat source (pork, horsemeat and a combination of both meat sources) and pH condition...
September 1, 2017: Meat Science
https://www.readbyqxmd.com/read/28887196/enhanced-expression-of-heme-oxygenase-1-in-the-locus-coeruleus-can-be-associated-with-anxiolytic-like-effects
#5
Rafael Alves Cazuza, Olga Pol, Christie Ramos Andrade Leite-Panissi
Some researchers have shown that carbon monoxide (CO) plays a role in emotional behavior modulation through intracellular 3'-5'-guanosine monophosphate mechanisms in the locus coeruleus (LC). In fact, the LC region has a high expression of the heme-oxygenase (HO) enzymes, which are responsible for the production of CO. However, the physiological mechanism by which the HO-CO pathway participates in the modulation of emotional responses in the LC still needs clarification. This study evaluates whether a systemic intraperitoneal treatment is able to alter behavioral responses (in the elevated plus-maze and the light-dark box test) and the expression of the HO-1 and HO-2 enzymes in the LC...
September 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28882957/5-aminolevulinic-acid-mediated-photodynamic-diagnosis-enhances-the-detection-of-peritoneal-metastases-in-biliary-tract-cancer-in-mice
#6
Toshihiro Kushibiki, Takehiro Noji, Yuma Ebihara, Koji Hontani, Masato Ono, Shota Kuwabara, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Masahiro Ishizuka, Satoshi Hirano
BACKGROUND/AIM: Previous studies on the accuracy of 5-aminolevulinic-acid-mediated photodynamic diagnosis (5-ALA PDD) have been reported for various cancers and brain surgery. However, biliary tract cancer is rare. Therefore, 5-ALA PDD has not been fully evaluated in biliary tract cancers. Small biliary tract cancer lesions such as peritoneal dissemination, liver metastases, and lymph node metastases are negative prognosticators in patients with biliary cancer. The purpose of this exploratory study was to determine if 5-ALA PDD could detect small biliary tract cancer lesions in murine models of biliary cancers...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28881299/photo-responsive-tetraether-lipids-based-vesicles-for-prophyrin-mediated-vascular-targeting-and-direct-phototherapy
#7
Gihan Mahmoud, Jarmila Jedelská, Boris Strehlow, Samia Omar, Marc Schneider, Udo Bakowsky
Tetraether lipids (TELs) derived from the thermoacidophilic archaeon Sulfolobus acidocaldarius are dominated by polyisoprenoid skeleton. The unique molecular stability of TELs is attributed to the presence of cyclopentane rings, methyl side groups and sugar residues that create extensive hydrogen bond network. In addition, the presence of ether linkages and the lacking of double bonds make them an epitome candidate for photodynamic therapy (PDT). A subtle blend of formulation design to trigger efficient photo responses of protoporphyrin IX (PpIX) exploiting TELs was developed...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28875108/three-in-one-approach-towards-efficient-organic-dye-sensitized-solar-cells-aggregation-suppression-panchromatic-absorption-and-resonance-energy-transfer
#8
Jayita Patwari, Samim Sardar, Bo Liu, Peter Lemmens, Samir Kumar Pal
In the present study, protoporphyrin IX (PPIX) and squarine (SQ2) have been used in a co-sensitized dye-sensitized solar cell (DSSC) to apply their high absorption coefficients in the visible and NIR region of the solar spectrum and to probe the possibility of Förster resonance energy transfer (FRET) between the two dyes. FRET from the donor PPIX to acceptor SQ2 was observed from detailed investigation of the excited-state photophysics of the dye mixture, using time-resolved fluorescence decay measurements...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28874591/mutation-in-human-clpx-elevates-levels-of-%C3%AE-aminolevulinate-synthase-and-protoporphyrin-ix-to-promote-erythropoietic-protoporphyria
#9
Yvette Y Yien, Sarah Ducamp, Lisa N van der Vorm, Julia R Kardon, Hana Manceau, Caroline Kannengiesser, Hector A Bergonia, Martin D Kafina, Zoubida Karim, Laurent Gouya, Tania A Baker, Hervé Puy, John D Phillips, Gaël Nicolas, Barry H Paw
Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyrias, eight forms of which have been described. The genetic penetrance of the porphyrias is clinically variable, underscoring the role of additional causative, contributing, and modifier genes. We previously discovered that the mitochondrial AAA+ unfoldase ClpX promotes heme biosynthesis by activation of δ-aminolevulinate synthase (ALAS), which catalyzes the first step of heme synthesis. CLPX has also been reported to mediate heme-induced turnover of ALAS...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28872077/-role-of-ppix-based-photodynamic-therapy-in-promoting-the-damage-and-apoptosis-of-colorectal-cancer-cell-and-its-mechanisms
#10
Guoqing Ouyang, Zhipeng Liu, Li Xiong, Xiang Chen, Qinglong Li, He Huang, Liangwu Lin, Xiongying Miao, Lun Ma, Wei Chen, Yu Wen
To explore the effects of protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) on induction of apoptosis and death in colon cancer cell and the underlying mechanisms.
 Methods: The cell killing effect of PDT on HCT116 cell was determined by cell counting kit (CCK). The cells were divided into a control group, a single light group, a single PpIX group, and a PDT group. Hoechst 33342 and flow cytometry was used to assess the cell apoptosis. Western blot was employed to analyze the expressions of bcl-2, bax, and caspase-3...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28870868/heme-oxygenase-1-participates-in-the-resolution-of-seawater-drowning-induced-acute-respiratory-distress-syndrome
#11
Jia-Jia Yuan, Xiao-Tong Zhang, Yun-Ting Bao, Xin-Jie Chen, Yuan-Zhao Shu, Jun-Liang Chen, Wei Chen, Bin Du, Qing-Feng Pang
The aim of the present study was to investigate whether heme oxygenase-1(HO-1) participated in the resolution of seawater drowning-induced acute respiratory distress syndrome (ARDS). In this study, gross and microscopic morphology of pulmonary tissue, computed tomography images and biochemical indexes were continuously observed from 15min to 15day after seawater drowning. The content and activity of HO-1 were determined by western-blot and spectrophotometric method, respectively. The morphological and biochemical indexes indicated that the seawater drowning could lead to the serious pulmonary hemorrhage and edema...
September 7, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28864672/the-coproporphyrin-ferrochelatase-of-staphylococcus-aureus-mechanistic-insights-into-a-regulatory-iron-binding-site
#12
Charlie Hobbs, J D Reid, Mark Shepherd
The majority of characterised ferrochelatase enzymes catalyse the final step of classical haem synthesis, inserting ferrous iron into protoporphyrin IX. However, for the recently-discovered coproporphyrin-dependent pathway, ferrochelatase catalyses the penultimate reaction where ferrous iron is inserted into coproporphyrin III. Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylococcus aureus are known to be inhibited by elevated iron concentrations...
September 1, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28860083/fluorescence-spectroscopy-in-the-visible-range-for-the-assessment-of-uvb-radiation-effects-in-hairless-mice-skin
#13
Carolina de Paula Campos, Camila de Paula D'Almeida, Marcelo Saito Nogueira, Lilian Tan Moriyama, Sebastião Pratavieira, Cristina Kurachi
Ultraviolet (UV) radiation may induce skin alterations as observed in photoaging. Some recognized modifications are epidermal hyperplasia, amorphous deposition of degraded elastic fibers and reduction in the number of collagen fibers. They alter the tissue biochemical properties that can be interrogated by steady state fluorescence spectroscopy (SSFS). In this study, we monitored the changes in endogenous fluorescence emission from hairless mice skin during a protocol of photoaging using UVB irradiation. To perform the fluorescence spectroscopy, it was used a violet laser (408nm) to induce the native fluorescence that is emitted in the visible range...
August 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28842674/hyperspectral-data-processing-improves-ppix-contrast-during-fluorescence-guided-surgery-of-human-brain-tumors
#14
J J Bravo, J D Olson, S C Davis, D W Roberts, K D Paulsen, S C Kanick
Fluorescence guided surgery (FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual contrast between normal and malignant tissue during resection of high grade gliomas. However, maps of the PpIX biodistribution within the surgical field based on either visual perception or the raw fluorescence emissions can be masked by background signals or distorted by variations in tissue optical properties. This study evaluates the impact of algorithmic processing of hyperspectral imaging acquisitions on the sensitivity and contrast of PpIX maps...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842241/photodynamic-diagnosis-of-visceral-pleural-invasion-of-lung-cancer-with-a-combination-of-5-aminolevulinic-acid-and-autofluorescence-observation-systems
#15
Masahiro Kitada, Yoshinobu Ohsaki, Syunnsuke Yasuda, Masahiro Abe, Nana Takahashi, Satoshi Okazaki, Kei Ishibashi, Satoshi Hayashi
BACKGROUND: Visceral pleural invasion (PL) is a prognostic factor in lung cancer. In the lung, lymph flows along the pleura, in addition to the flow toward the pulmonary hilum just as the pulmonary arteries and veins run toward it. Even with the same tumor diameter, a PL1 or higher level of pleural invasion is indicative of a more advanced disease stage. Final diagnosis based on the PL level is made by pathological examination of excised specimens. However, if an intraoperative diagnosis can be established, proper selection of the surgical procedure can be made, and unnecessary surgeries for disseminated lesions can be avoided...
August 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28836188/heme-oxygenase-1-inducing-activity-of-4-methoxydalbergione-and-4-hydroxy-4-methoxydalbergione-from-dalbergia-odorifera-and-their-anti-inflammatory-and-cytoprotective-effects-in-murine-hippocampal-and-bv2-microglial-cell-line-and-primary-rat-microglial-cells
#16
Dong-Cheol Kim, Dong-Sung Lee, Wonmin Ko, Kwan-Woo Kim, Hye Jin Kim, Chi-Su Yoon, Hyuncheol Oh, Youn-Chul Kim
Dalbergia odorifera T. Chen (Leguminosae) grows in Central and South America, Africa, Madagascar, and Southern Asia. D. odorifera possesses many useful pharmacological properties, such as antioxidative and anti-inflammatory activities in various cell types. 4-Methoxydalbergione (MTD) and 4'-hydroxy-4-methoxydalbergione (HMTD) were isolated from the EtOH extract of D. odorifera by several chromatography methods. The chemical structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrum (MS)...
August 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28827456/thioredoxin-and-nadph-dependent-thioredoxin-reductase-c-regulation-of-tetrapyrrole-biosynthesis
#17
Qingen Da, Peng Wang, Menglong Wang, Ting Sun, Honglei Jin, Bing Liu, Jinfa Wang, Bernhard Grimm, Hong-Bin Wang
In chloroplasts, thioredoxin (TRX) isoforms and NADPH-dependent thioredoxin reductase C (NTRC) act as redox regulatory factors involved in multiple plastid biogenesis and metabolic processes. To date, less is known about the functional coordination between TRXs and NTRC in chlorophyll (Chl) biosynthesis. In this study, we aimed to explore the potentially functions of TRX m and NTRC in the regulation of the tetrapyrrole biosynthesis (TBS) pathway. Silencing of three genes, TRX m1, TRX m2, and TRX m4 (TRX ms), led to pale-green leaves, a significantly reduced 5-aminolevulinic acid (ALA)-synthesizing capacity, and reduced accumulation of Chl and its metabolic intermediates in Arabidopsis thaliana...
August 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28822969/preconditioning-with-the-bkca-channel-activator-ns-1619-prevents-ischemia-reperfusion-induced-inflammation-and-mucosal-barrier-dysfunction-ros-and-ho-1
#18
Hongyan Dai, Meifang Wang, Parag N Patel, Theodore J Kalogeris, Yajun Liu, William Durante, Ronald J Korthuis
Activation of large conductance, calcium-activated potassium (BKCa) channels evokes cell survival programs that mitigate intestinal ischemia and reperfusion (I/R) inflammation and injury 24 hours later. The goal of the current study was to determine the role of reactive oxygen species (ROS) and heme oxygenase (HO)-1 in delayed acquisition of tolerance to I/R induced by pretreatment with the BKCa channel opener NS-1619. Superior mesentery arteries were occluded for 45 min followed by reperfusion for 70 min in wild type (WT) or HO-1 null (HO-1(-/-)) mice that were pretreated with NS-1619 or saline vehicle 24 hrs earlier...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28821132/the-effect-of-%C3%AE-cyclodextrin-on-poly-pseudo-rotaxane-nanoparticles-self-assembled-by-protoporphyrin-modified-poly-ethylene-glycol-for-anticancer-drug-delivery
#19
Taotao Xu, Junhua Li, Jun Cao, Wenxia Gao, Li Li, Bin He
Poly(pseudo)rotaxane (PPR) nanoparticles was facilely prepared using poly(ethylene glycol) (PEG) modified with protoporphyrin (PpIX) and α-cyclodextrin (α-CD) via host-guest interaction, the effect of α-CD number on the nanoparticle properties was investigated. The PEG with protoporphyrin (PEG-PpIX) end capping was synthesized via coupling reaction and the poly(pseudo)rotaxane nanoparticles with different amount of α-CD were fabricated by host-guest interaction between mPEG-PpIX and α-CDs. The final product was characterized by nuclear magnetic spectrum ((1)H NMR), X-ray diffraction (XRD), atomic force microscope (AFM) and dynamic light scattering (DLS)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820893/a-computational-method-for-the-identification-of-candidate-drugs-for-non-small-cell-lung-cancer
#20
Lei Chen, Jing Lu, Tao Huang, Yu-Dong Cai
Lung cancer causes a large number of deaths per year. Until now, a cure for this disease has not been found or developed. Finding an effective drug through traditional experimental methods invariably costs millions of dollars and takes several years. It is imperative that computational methods be developed to integrate several types of existing information to identify candidate drugs for further study, which could reduce the cost and time of development. In this study, we tried to advance this effort by proposing a computational method to identify candidate drugs for non-small cell lung cancer (NSCLC), a major type of lung cancer...
2017: PloS One
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