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Protoporphyrin ix

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https://www.readbyqxmd.com/read/29760987/5-ala-fluorescence-and-laser-doppler-flowmetry-for-guidance-in-a-stereotactic-brain-tumor-biopsy
#1
Neda Haj-Hosseini, Johan C O Richter, Peter Milos, Martin Hallbeck, Karin Wårdell
A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29755830/effects-of-substrate-and-polymer-encapsulation-on-co-2-electroreduction-by-immobilized-indium-iii-protoporphyrin
#2
Yuvraj Y Birdja, Rafaël E Vos, Tim A Wezendonk, Lin Jiang, Freek Kapteijn, Marc T M Koper
Heterogenization of molecular catalysts for CO2 electroreduction has attracted significant research activity, due to the combined advantages of homogeneous and heterogeneous catalysts. In this work, we demonstrate the strong influence of the nature of the substrate on the selectivity and reactivity of electrocatalytic CO2 reduction, as well as on the stability of the studied immobilized indium(III) protoporphyrin IX, for electrosynthesis of formic acid. Additionally, we investigate strategies to improve the CO2 reduction by tuning the chemical functionality of the substrate surface by means of electrochemical and plasma treatment and by catalyst encapsulation in polymer membranes...
May 4, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29752102/cyclodextrin-and-dendrimer-conjugated-graphene-oxide-as-a-nanocarrier-for-the-delivery-of-selected-chemotherapeutic-and-photosensitizing-agents
#3
Ampornphan Siriviriyanun, Ya-Ju Tsai, Siew Hui Voon, Siaw Fui Kiew, Toyoko Imae, Lik Voon Kiew, Chung Yeng Looi, Won Fen Wong, Hong Boon Lee, Lip Yong Chung
In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug loading on GO-CD-DEN increased in the order: DOX < PpIX < CPT...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29746502/potential-involvement-of-the-18-kda-translocator-protein-and-reactive-oxygen-species-in-apoptosis-of-thp-1-macrophages-induced-by-sonodynamic-therapy
#4
Xin Sun, Shuyuan Guo, Wei Wang, Zhengyu Cao, Juhua Dan, Jiali Cheng, Wei Cao, Fang Tian, Wenwu Cao, Ye Tian
Sonodynamic therapy (SDT) with exogenous protoporphyrin IX (PpIX) or endogenous PpIX derived from 5-aminolevulinic acid (ALA) has been carried out to produce apoptotic effects on macrophages, indicating a potential treatment methodology for atherosclerosis. Our previous studies have found that mitochondria damage by reactive oxygen species (ROS) plays a major role in the SDT-induced apoptosis. This study aimed at investigating the potential involvement of the mitochondrial 18 kDa translocator protein (TSPO) and ROS in the pro-apoptotic effects of SDT on THP-1 macrophages...
2018: PloS One
https://www.readbyqxmd.com/read/29743981/induction-of-nlrp3-inflammasome-activation-by-heme-in-human-endothelial-cells
#5
Judit Erdei, Andrea Tóth, Enikő Balogh, Benard Bogonko Nyakundi, Emese Bányai, Bernhard Ryffel, György Paragh, Mario D Cordero, Viktória Jeney
Hemolytic or hemorrhagic episodes are often associated with inflammation even when infectious agents are absent suggesting that red blood cells (RBCs) release damage-associated molecular patterns (DAMPs). DAMPs activate immune and nonimmune cells through pattern recognition receptors. Heme, released from RBCs, is a DAMP and induces IL-1 β production through the activation of the nucleotide-binding domain and leucine-rich repeat-containing family and pyrin domain containing 3 (NLRP3) in macrophages; however, other cellular targets of heme-mediated inflammasome activation were not investigated...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29743446/photodynamic-therapy-using-talaporfin-sodium-induces-heme-oxygenase-1-expression-in-rat-malignant-meningioma-kmy-j-cells
#6
Tsutomu Takahashi, Saki Suzuki, Suzuka Misawa, Jiro Akimoto, Yo Shinoda, Yasuyuki Fujiwara
Photodynamic therapy (PDT) using talaporfin sodium (TS) is tumor cell-selective less invasive therapy for the treatment of malignant glioma. We previously demonstrated that PDT using TS (TS-PDT) treatment exhibits anti-tumor activity against not only glioblastoma cells but also malignant meningioma cells. In general, various stress response proteins have been reported to affect the sensitivity determination for anticancer agents against tumor cells. However, the relationship between the therapeutic effect of TS-PDT and stress response systems in tumor cells is not adequately investigated...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29742173/photodynamic-diagnosis-with-methyl-5-aminolevulinate-in-squamous-intraepithelial-lesions-of-the-vulva-experimental-research
#7
Lea Leufflen, Aurelie Francois, Julia Salleron, Catherine Barlier, Gilles Dolivet, Frederic Marchal, Lina Bezdetnaya
The incidence of the High-grade Squamous Intraepithelial Lesion of the vulva, formerly vulvar intra-epithelial neoplasia is progressively increasing. Today, an early detection and a precise localization of vulvar lesions are still problematic issues, due to the lack of accuracy of the available diagnostic tool. A new approach is the photodynamic diagnosis based on the fluorescence detection of protoporphyrin IX (PpIX) in cancer cells after topical application of a cream of methyl amino-levulinic acid. This study aimed to evaluate the effectiveness of photodiagnosis in order to discriminate the intensity of PpIX fluorescence between vulvar tumor and healthy skin...
2018: PloS One
https://www.readbyqxmd.com/read/29738777/heme-oxygenase-1-inhibitor-tin-protoporphyrin-improves-liver-regeneration-after-partial-hepatectomy
#8
Monica Pibiri, Vera Piera Leoni, Luigi Atzori
AIMS: This study investigates the effects of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO-1 in the regulation of cellular growth. MAIN METHODS: Male Wistar rats received a subcutaneous injection of either SnPP (10 μmoles/kg body weight) or saline 12 h before PH and 0, 12 and 24 h after surgery. Rats were killed from 0.5 to 36 h after PH...
May 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29737540/5-ala-in-the-management-of-malignant-glioma
#9
REVIEW
Herbert Stepp, Walter Stummer
BACKGROUND: Patients suffering from malignant gliomas have a poor prognosis. For the surgical treatment of these tumors, 5-aminolevulinic acid (5-ALA) has become a new standard. AIMS: This review intends to provide an overview over current status, significance, limitations, and future perspectives of 5-ALA based fluorescence guided surgery and photodynamic therapy for brain tumor patients. MATERIALS AND METHODS: From peer reviewed publications on the many aspects connected with this topic, those with potential clinical relevance were selected and put in the context of our own experience...
May 8, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29729387/characterisation-of-anopheles-gambiae-heme-oxygenase-and-metalloporphyrin-feeding-suggests-a-potential-role-in-reproduction
#10
Christopher S Spencer, Cristina Yunta, Glauber Pacelli Gomes de Lima, Kay Hemmings, Lu-Yun Lian, Gareth Lycett, Mark J I Paine
The mosquito Anopheles gambiae is the principal vector for malaria in sub-Saharan Africa. The ability of A. gambiae to transmit malaria is strictly related to blood feeding and digestion, which releases nutrients for oogenesis, as well as substantial amounts of highly toxic free heme. Heme degradation by heme oxygenase (HO) is a common protective mechanism, and a gene for HO exists in the An. gambiae genome HO (AgHO), although it has yet to be functionally examined. Here, we have cloned and expressed An. gambiae HO (AgHO) in E...
May 2, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29721068/enhancement-of-cancer-specific-protoporphyrin-ix-fluorescence-by-targeting-oncogenic-ras-mek-pathway
#11
Ema Yoshioka, Vipin Shankar Chelakkot, Maria Licursi, Suzette G Rutihinda, Jayoti Som, Leena Derwish, Justin J King, Theerawat Pongnopparat, Karen Mearow, Mani Larijani, Ann M Dorward, Kensuke Hirasawa
Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA). This cancer-specific accumulation of PpIX is used to distinguish tumor from normal tissues in fluorescence-guided surgery (FGS) and to destroy cancer cells by photodynamic therapy (PDT). In this study, we demonstrate that oncogenic Ras/mitogen-activated protein kinase kinase (MEK) pathway can modulate PpIX accumulation in cancer cells. Methods: To identify Ras downstream elements involved in PpIX accumulation, chemical inhibitors were used...
2018: Theranostics
https://www.readbyqxmd.com/read/29708549/an-in-vitro-model-to-study-the-effect-of-5-aminolevulinic-acid-mediated-photodynamic-therapy-on-staphylococcus-aureus-biofilm
#12
Ke-Qing Zhao, Yang Wu, Yu-Xi Yi, Si-Jia Feng, Ruo-Yan Wei, Ying Ma, Chun-Quan Zheng, Di Qu
Staphylococcus aureus (S. aureus) is a common human pathogen, which causes pyogenic and systemic infections. S. aureus infections are difficult to eradicate not only due to the emergence of antibiotic-resistant strains but also its ability to form biofilms. Recently, photodynamic therapy (PDT) has been indicated as one of the potential treatments for controlling biofilm infections. However, further studies are required to improve our knowledge of its effect on bacterial biofilms, as well as the underlying mechanisms...
April 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683283/the-background-and-philosophy-behind-daylight-photodynamic-therapy
#13
Hans C Wulf
BACKGROUND: Conventional photodynamic therapy (PDT) is associated with side effects, primarily related to the waiting time between pre-treatment with application of photosensitizer and illumination. Pain during illumination is a major issue for the patients and options for effective pain relief are limited. Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers. METHODS: To avoid the problems of pain and patients crowding in the clinic we eliminated red light treatment of high PpIX concentration and introduced illumination in daylight which may be performed at home...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29669207/ros-inducing-micelles-sensitize-tumor-associated-macrophages-to-tlr3-stimulation-for-potent-immunotherapy
#14
Lanlan Liu, Huamei He, Ruijing Liang, Huqiang Yi, Xiaoqing Meng, Zhikuan Chen, Hong Pan, Yifan Ma, Lintao Cai
One approach to cancer immunotherapy is the repolarization of immunosuppressive tumor-associated macrophages (TAMs) to anti-tumor M1 macrophages. The present study developed galactose-functionalized zinc protoporphyrin IX (ZnPP) grafted poly(L-lysine)-b-poly(ethyleneglycol) polypeptide micelles (ZnPP PM ) for TAM-targeted immunopotentiator delivery, which aimed at in vivo repolarization of TAMs to anti-tumor M1 macrophages. The outcomes revealed that ROS-inducing ZnPP PM demonstrated specificity for the in vitro and in vivo targeting of macrophages, elevated the level of ROS, and lowered STAT3 expression in BM-TAMs...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#15
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29650943/-a-useful-case-of-photodynamic-diagnosis-of-inferior-vena-cava-invasion-by-pancreatic-head-cancer-using-5-aminolevulinic-acid-5-ala
#16
Toru Mizutani, Yasutoshi Murayama, Hisashi Ikoma, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Yoshiaki Kuriu, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Curative resection is necessary to survival in pancreatic cancer, however after surgery, pathologic examination sometimes diagnoses the remains of cancer at the resected stump. Therefore, it is necessary to evaluate the stump by intraoperative rapid pathological examination. 5-aminolevulinic acid(5-ALA)is an endogenous natural amino acid and precursor of the heme pathway. 5-ALA is metabolized and accumulated as protoporphyrin IX(Pp IX)that is photosensitive substance. 5-ALA mediated photodynamic diagnosis(PDD)(ALA-PDD)has high diagnostic ability...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29642608/neuroprotective-effects-of-four-phenylethanoid-glycosides-on-h%C3%A2-o%C3%A2-induced-apoptosis-on-pc12-cells-via-the-nrf2-are-pathway
#17
Maiquan Li, Tao Xu, Fei Zhou, Mengmeng Wang, Huaxin Song, Xing Xiao, Baiyi Lu
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H₂O₂-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM)...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29619546/clinical-application-of-photodynamic-medicine-technology-using-light-emitting-fluorescence-imaging-based-on-a-specialized-luminous-source
#18
REVIEW
Tsutomu Namikawa, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Michiya Kobayashi, Kazuhiro Hanazaki
The natural amino acid 5-aminolevulinic acid (ALA) is a protoporphyrin IX (PpIX) precursor and a new-generation photosensitive substance that accumulates specifically in cancer cells. When indocyanine green (ICG) is irradiated with near-infrared (NIR) light, it shifts to a higher energy state and emits infrared light with a longer wavelength than the irradiated NIR light. Photodynamic diagnosis (PDD) using ALA and ICG-based NIR fluorescence imaging has emerged as a new diagnostic technique. Specifically, in laparoscopic examinations for serosa-invading advanced gastric cancer, peritoneal metastases could be detected by ALA-PDD, but not by conventional visible-light imaging...
April 4, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29615690/porphyrins-inactivate-nosema-spp-microsporidia
#19
Aneta A Ptaszyńska, Mariusz Trytek, Grzegorz Borsuk, Katarzyna Buczek, Katarzyna Rybicka-Jasińska, Dorota Gryko
The study of organic/inorganic molecules with activity against intracellular fungi of the phylum Microsporidia is of critical importance. Here, for the first time, the inactivation of these parasitic fungi by porphyrins is reported. The biological effects of porphyrins (10 µM and 100 µM) on the microsporidian Nosema ceranae was investigated in honeybee hosts using cage experiments. A significant reduction in the number of spores (from 2.6 to 5 fold) was observed in Nosema-infected honeybees with a sucrose-protoporphyrin amide [PP(Asp)2 ] syrup diet compared to the control honeybees...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611819/protoporphyrin-ix-conjugated-cellulose-nanofibers-that-exhibit-high-antibacterial-photodynamic-inactivation-efficacy
#20
Jiancheng Dong, Reza A Ghiladi, Qingqing Wang, Yibing Cai, Qufu Wei
Towards the development of anti-infective nanoscale materials employing a photodynamic mechanism of action, we report the synthesis, physical properties (SEM, mechanical strength, water contact angle), spectroscopic characterization (infrared, Raman, DRUV), and evaluation of antibacterial efficacy of porphyrin-conjugated regenerated cellulose nanofibers, termed RC-TETA-PPIX-Zn. Cellulose acetate was electrospun to produce nanofibers, thermally treated to enhance mechanical strength, and finally hydrolyzed to produce regenerated cellulose (RC) nanofibers that possessed a high surface area and nanofibrous structure...
April 3, 2018: Nanotechnology
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