keyword
https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#1
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38537024/evaluation-the-stress-distribution-in-root-canals-by-3d-finite-element-analysis-after-the-materials-used-in-reattaching-the-vertically-root-fractured-fragments
#2
JOURNAL ARTICLE
Senem Yiğit Özer, Salih Danişman, Törem Özer
The aim was to evaluate the effect of stress distribution on vertical, horizontal, and oblique forces on the tooth model after reattaching the fragments of the maxillary incisor with vertical root fracture (VRF) using different materials, by 3D finite element analysis (FEA). Tooth with a root canal, spongious, and cortical bone models were designed. VRF was modeled on a tooth with 4 different re-attachment models: Group 1: dual-cure cement (DC)+fiber reinforced composite (FRC), Group 2: DC+polyethylene fiber, Group 3: DC+glass fiber, and Group 4:DC...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#3
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38536647/differences-in-injury-profiles-between-female-and-male-athletes-across-the-participant-classification-framework-a-systematic-review-and-meta-analysis
#4
Natalie J Hardaker, Patria A Hume, Stacy T Sims
BACKGROUND: Female sex is a significant determinant of anterior cruciate ligament (ACL) injury. It is not understood if sex is a key determinant of other sports-related injuries. OBJECTIVE: The aim of this systematic review was to identify where differences in injury profiles are most apparent between the sexes in all sports across the six-tiered participant classification framework. METHODS: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the 'implementing PRISMA in Exercise, Rehabilitation, Sport medicine and SporTs science'(PERSiST) guidance...
March 27, 2024: Sports Medicine
https://read.qxmd.com/read/38536562/exome-sequencing-identified-mutations-in-the-wnt1-and-col1a2-genes-in-osteogenesis-imperfecta-cases
#5
JOURNAL ARTICLE
Poonam Mehta, Rahul Vishvkarma, Sushil Gupta, Naibedya Chattopadhyay, Singh Rajender
BACKGROUND: Osteogenesis imperfecta (OI) is a heritable connective tissue disorder characterized by bone deformities, fractures and reduced bone mass. OI can be inherited as a dominant, recessive, or X-linked disorder. The mutational spectrum has shown that autosomal dominant mutations in the type I collagen-encoding genes are responsible for OI in 85% of the cases. Apart from collagen genes, mutations in more than 20 other genes, such as CRTAP, CREB3L1, MBTPS2, P4HB, SEC24D, SPARC, FKBP10, LEPRE1, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1, TMEM38B, and IFITM5 have been reported in OI...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536478/effectiveness-of-calcimimetics-on-fractures-in-dialysis-patients-with-secondary-hyperparathyroidism-meta-analysis-of-randomized-trials
#6
JOURNAL ARTICLE
Takuya Wakamatsu, Suguru Yamamoto, Koji Matsuo, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa, Junichiro James Kazama
INTRODUCTION: This study aimed to assess the effectiveness of calcimimetics in reducing the risk of fractures in dialysis patients with secondary hyperparathyroidism (SHPT). MATERIAL AND METHODS: A comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library for articles published through December 9, 2023. The quality of each trial was evaluated using the Cochrane Collaboration tool. Meta-analysis was performed using a random-effects model, and effect measures across studies were synthesized...
March 27, 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38536446/metformin-treatment-reduces-the-incidence-of-osteoporosis-a-two-sample-mendelian-randomized-study
#7
JOURNAL ARTICLE
Yaotian Cai, Gao Jun, Xiaojie Zhuang
UNLABELLED: It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment and a decrease in OP and fracture incidence, as well as an increase in bone mineral density (BMD) in the lumbar spine, femoral neck, and heel. Nonetheless, no significant causal effect is observed on forearm BMD. PURPOSE: We utilize a MR approach to investigate the association between metformin treatment and the risk of OP...
March 27, 2024: Osteoporosis International
https://read.qxmd.com/read/38535701/exploring-the-application-of-graphene-oxide-based-nanomaterials-in-the-repair-of-osteoporotic-fractures
#8
REVIEW
Hongfa Zhou, Jinyuan Chen, Xuan Zhang, JingJing Chen, Jiayou Chen, Shicheng Jia, Deli Wang, Hui Zeng, Jian Weng, Fei Yu
Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing osteoporotic fractures. It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages in tissue engineering due to their excellent biocompatibility, mechanical properties, and osteoinductive abilities...
March 21, 2024: Nanomaterials
https://read.qxmd.com/read/38535259/bone-marrow-derived-mesenchymal-stem-cell-laden-nanocomposite-scaffolds-enhance-bone-regeneration-in-rabbit-critical-size-segmental-bone-defect-model
#9
JOURNAL ARTICLE
Elangovan Kalaiselvan, Swapan Kumar Maiti, Shivaraju Shivaramu, Shajahan Amitha Banu, Khan Sharun, Divya Mohan, Sangeetha Palakkara, Sadhan Bag, Monalisa Sahoo, Suresh Ramalingam, Jürgen Hescheler
Bone regeneration poses a significant challenge in the field of tissue engineering, prompting ongoing research to explore innovative strategies for effective bone healing. The integration of stem cells and nanomaterial scaffolds has emerged as a promising approach, offering the potential to enhance regenerative outcomes. This study focuses on the application of a stem cell-laden nanomaterial scaffold designed for bone regeneration in rabbits. The in vivo study was conducted on thirty-six healthy skeletally mature New Zealand white rabbits that were randomly allocated into six groups...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535017/ai-assisted-x-ray-fracture-detection-in-residency-training-evaluation-in-pediatric-and-adult-trauma-patients
#10
JOURNAL ARTICLE
Mathias Meetschen, Luca Salhöfer, Nikolas Beck, Lennard Kroll, Christoph David Ziegenfuß, Benedikt Michael Schaarschmidt, Michael Forsting, Shamoun Mizan, Lale Umutlu, René Hosch, Felix Nensa, Johannes Haubold
Background : This study aimed to evaluate the impact of an AI-assisted fracture detection program on radiology residents' performance in pediatric and adult trauma patients and assess its implications for residency training. Methods : This study, conducted retrospectively, included 200 radiographs from participants aged 1 to 95 years (mean age: 40.7 ± 24.5 years), encompassing various body regions. Among these, 50% (100/200) displayed at least one fracture, totaling one hundred thirty-five fractures, assessed by four radiology residents with different experience levels...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534548/correlation-between-malocclusion-and-mandibular-fractures-an-experimental-study-comparing-dynamic-finite-element-models-and-clinical-case-studies
#11
JOURNAL ARTICLE
Giorgio Novelli, Andrea Filippi, Andrea Cartocci, Sergio Mirabella, Marco Talarico, Elena De Ponti, Maria Costanza Meazzini, Davide Sozzi, Gabriele Canzi, Marco Anghileri
Mandibular fractures are very common in maxillofacial trauma surgery. While previous studies have focused on possible risk factors related to post-operative complications, none have tried to identify pre-existing conditions that may increase the risk of mandibular fractures. We hypothesized, through clinical observation, that anatomical conditions involving poor dental contacts, such as malocclusions, may increase the risk of mandibular fractures. This work was subdivided into two parts. In the first part, Digital Imaging and Communications in Medicine (DICOM) data of four healthy patients characterized by different dentoskeletal occlusions (class I, class II, class III, and anterior open bite) have been used to develop four finite element models (FEMs) that accurately reproduce human bone structure...
March 12, 2024: Bioengineering
https://read.qxmd.com/read/38534368/unique-spatial-transcriptomic-profiling-of-the-murine-femoral-fracture-callus-a-preliminary-report
#12
JOURNAL ARTICLE
Will Jiang, Dennis L Caruana, Jungho Back, Francis Y Lee
Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Previous sequencing techniques such as single-cell RNA and in situ hybridization are limited by missing spatial context and low throughput, respectively. We present a preliminary approach using the Visium CytAssist spatial transcriptomics platform to provide the first spatially intact characterization of genetic expression changes within an orthopedic model of impaired fracture healing...
March 16, 2024: Cells
https://read.qxmd.com/read/38534304/the-long-term-esthetic-and-radiographic-outcome-of-implants-placed-in-the-anterior-maxilla-after-ridge-preservation-combining-bovine-xenograft-with-collagen-matrix
#13
JOURNAL ARTICLE
Leonidas Batas, Vithleem Xanthopoulou, Maria Gnigou, Triantafyllia Vagdouti, Ioannis Fragkioudakis, Ioannis Vouros
The objective of the study was to evaluate the long-term esthetic and radiographic results of implants placed in the anterior maxilla after ridge preservation, combining bovine xenograft with collagen matrix. Fifteen patients who required a single tooth extraction because of fracture, root resorption, or extended caries were included in the study. After extraction, all sites were grafted using Deproteinized Bovine Bone Mineral (DBBM) with collagen and covered by a resorbable collagen matrix (CM). Five months after socket grafting, implants were successfully installed...
March 20, 2024: Dentistry Journal
https://read.qxmd.com/read/38534217/development-of-aav-mediated-gene-therapy-approaches-to-treat-skeletal-diseases
#14
JOURNAL ARTICLE
Chujiao Lin, Matthew Greenblatt, Guangping Gao, Jae-Hyuck Shim
Adeno-associated viral (AAV) vectors have emerged as crucial tools in advancing gene therapy for skeletal diseases, offering the potential for sustained expression with low post-infection immunogenicity and pathogenicity. Preclinical studies support both the therapeutic efficacy and safety of these vectors, illustrating the promise of AAV-mediated gene therapy. Emerging technologies and innovations in AAV-mediated gene therapy strategies, such as gene addition, gene replacement, gene silencing, and gene editing, offer new approaches to clinical application...
March 27, 2024: Human Gene Therapy
https://read.qxmd.com/read/38534184/orbital-fracture-characteristics-and-outcomes-in-baltimore
#15
JOURNAL ARTICLE
Seray Er, Bashar Hassan, Joshua Yoon, Eric Resnick, Cynthia Yusuf, Tomer Lagziel, Fan Liang, Thomas Ptak, Richard Redett, Robin Yang, Michael Grant
Fracture characteristics and postoperative outcomes of patients presenting with orbital fractures in Baltimore remain poorly investigated. The purpose of our study was to determine the fracture patterns, etiologies, and postoperative outcomes of patients treated for orbital fractures at 2 level I trauma centers in Baltimore. A retrospective cohort study was conducted on patients who underwent orbital fracture repair at the R Adams Cowley Shock Trauma Center and the Johns Hopkins Hospital from January 2015 to December 2019...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38534175/the-association-between-craniofacial-fracture-patterns-and-traumatic-optic-neuropathy
#16
JOURNAL ARTICLE
Bashar Hassan, Joshua Yoon, Adekunle Elegbede, Shannath L Merbs, Fan Liang, Neil R Miller, Paul N Manson, Michael P Grant
Traumatic optic neuropathy (TON) is a rare but potentially devastating complication of craniofacial trauma. Approximately half of patients with TON sustain permanent vision loss. In this study, we sought to identify the most common fracture patterns associated with TON. We performed a retrospective review of craniomaxillofacial CT scans of trauma patients who presented to the R Adams Cowley Shock Trauma Center from 2015 to 2017. Included were adult patients who had orbital fractures with or without other facial fractures...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#17
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38534035/adverse-jaw-outcomes-from-immune-checkpoint-inhibitors-for-head-and-neck-cancer-case-reports
#18
JOURNAL ARTICLE
Gayathri Subramanian, Vincent Yeung, Soly Baredes, Sung Kim, Tessa Bergsbaken, Samuel Quek
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs. Adverse impacts on bone secondary to medications such as pembrolizumab and nivolumab have been sporadically documented in the literature. The objective of this manuscript is to raise awareness of possible increase in risk for adverse jaw outcomes in patients with HNSCCs exposed to both radiation treatment to the jaws and ICI therapy...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38533814/comparison-of-exposure-of-the-radius-afforded-by-the-craniomedial-and-craniolateral-open-surgical-approaches-in-dog-cadavers
#19
JOURNAL ARTICLE
S K Crowdis, D D Lewis
Management of antebrachial fractures in dogs typically involves open reduction and bone plate stabilisation of the radius performed using either a craniomedial approach (CMA) or craniolateral approach (CLA). The aim of this cadaveric study was to compare radial exposure afforded via the craniomedial and craniolateral approaches, without and with releasing the abductor digiti I longus (ADIL) muscle. The CMA and CLA were performed on alternate paired cadaver forelimbs with the subsequent release (CMA) or elevation (CLA) of the ADIL muscle ( n = 12)...
March 26, 2024: Journal of the South African Veterinary Association
https://read.qxmd.com/read/38532975/explaining-and-predicting-the-increased-thorax-injury-in-aged-females-age-and-subject-specific-thorax-geometry-coupled-with-improved-bone-constitutive-models-and-age-specific-material-properties-evaluated-in-side-impact-conditions
#20
JOURNAL ARTICLE
Miguel A Corrales, John Henry Bolte, Bengt Pipkorn, Craig Markusic, Duane S Cronin
Predicting and understanding thorax injury is fundamental for the assessment and development of safety systems to mitigate injury risk to the increasing and vulnerable aged population. While computational human models have contributed to the understanding of injury biomechanics, contemporary human body models have struggled to predict rib fractures and explain the increased incidence of injury in the aged population. The present study enhanced young and aged human body models (HBMs) by integrating a biofidelic cortical bone constitutive model and population-based bone material properties...
2024: Frontiers in Public Health
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