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https://www.readbyqxmd.com/read/29168740/dietary-intake-of-cadmium-lead-and-mercury-and-its-association-with-bone-health-in-healthy-premenopausal-women
#1
Jesus M Lavado-García, Luis M Puerto-Parejo, Raul Roncero-Martín, Jose M Moran, Juan D Pedrera-Zamorano, Ignacio J Aliaga, Olga Leal-Hernández, Maria L Canal-Macias
The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168668/the-occurrence-of-fractures-after-adjuvant-treatment-of-breast-cancer-a-dbcg-register-study
#2
Bent Kristensen, Bent Ejlertsen, Maj-Britt Jensen, Henning T Mouridsen
BACKGROUND: Adjuvant treatment in breast cancer patients especially with aromatase inhibitors (AIs) has adverse effects on bone metabolism resulting in an increased occurrence of fractures. In order to demonstrate this occurrence, long-term follow-up studies are necessary. From several national registries in Denmark, it is possible to link data from different sources and analyze this issue. METHODS: A study cohort of 68,842 breast cancer patients prospectively diagnosed and registered in the Danish Breast Cancer Cooperative Group's database during the period 1995-2012 formed the basis of the analysis...
November 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29168404/impact-of-a-chronic-pain-management-pathway-on-opioid-administration-and-prescribing-in-an-emergency-department
#3
Caroline Pace, Sneha Shah, Amy X Zhang, Amy E Zosel
CONTEXT: Prescription opioid abuse and misuse is a significant public health crisis. In 2012, an opioid prescribing pathway for patients with chronic pain presenting to the Emergency Department (ED) was implemented. The objective of this study is to determine the impact of the pathway for administration of opioids in the ED as well as the prescribing of opioids for home use after discharge. METHODS: Retrospective pre- and post-intervention time series study of consecutive patients presenting to the ED with acute and chronic pain complaints before and after implementation of the pathway...
November 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29167980/role-of-isolated-percutaneous-autologous-platelet-concentrate-in-delayed-union-of-long-bones
#4
Gipson Samuel, Jagdish Menon, Sreenivas Thimmaiah, Gayadhar Behera
PURPOSE: The objective of this study is to evaluate the efficacy of percutaneous platelet concentrate (PC) injection in increasing the chances of attaining union in delayed union of long bones and to know whether the time taken for union decreases with use of PC. METHODS: Forty delayed unions (15-30 weeks old) were randomized into a study group in which autologous PC prepared by blood bank centrifuge was percutaneously injected at the fracture site under image intensifier after activation with 10% calcium gluconate and a control group where patients were observed over time...
November 22, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29167971/abaloparatide-sc-improves-trabecular-microarchitecture-as-assessed-by-trabecular-bone-score-tbs-a-24-week-randomized-clinical-trial
#5
J P Bilezikian, G Hattersley, L A Fitzpatrick, A G Harris, E Shevroja, K Banks, B Z Leder, J R Zanchetta, D Hans
In a phase 2 trial of 222 postmenopausal women with osteoporosis aged 55 to 85 years randomized to one of three different doses of abaloparatide-SC, subcutaneous teriparatide, or placebo for 24 weeks, abaloparatide-SC resulted in improvements in skeletal microarchitecture as measured by the trabecular bone score. INTRODUCTION: Subcutaneous abaloparatide (abaloparatide-SC) increases total hip and lumbar spine bone mineral density and reduces vertebral and non-vertebral fractures. In this study, we analyzed the extent to which abaloparatide-SC improves skeletal microarchitecture, assessed indirectly by trabecular bone score (TBS)...
November 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29167970/independent-association-of-bone-mineral-density-and-trabecular-bone-score-to-vertebral-fracture-in-male-subjects-with-chronic-obstructive-pulmonary-disease
#6
R Watanabe, N Tai, J Hirano, Y Ban, D Inoue, R Okazaki
Osteoporosis is a major comorbidity of chronic obstructive pulmonary disease (COPD), but the mechanism of bone fragility is unknown. We demonstrated that trabecular bone score, a parameter of bone quality, was associated with systemic inflammation and was a significant determinant of vertebral fracture independent of bone mineral density. INTRODUCTION: COPD is a major cause of secondary osteoporosis. However, the mechanism of bone fragility is unclear. We previously reported that vertebral fracture was highly prevalent in male COPD patients...
November 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29167969/association-of-incident-hip-fracture-with-the-estimated-femoral-strength-by-finite-element-analysis-of-dxa-scans-in-the-osteoporotic-fractures-in-men-mros-study
#7
L Yang, N Parimi, E S Orwoll, D M Black, J T Schousboe, R Eastell
Finite element model can estimate bone strength better than BMD. This study used such a model to determine its association with hip fracture risk and found that the strength estimate provided limited improvement over the hip BMDs in predicting femoral neck (FN) fracture risk only. INTRODUCTION: Bone fractures occur only when it is loaded beyond its ultimate strength. The goal of this study was to determine the association of femoral strength, as estimated by finite element (FE) analysis of DXA scans, with incident hip fracture as a single condition or with femoral neck (FN) and trochanter (TR) fractures separately in older men...
November 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29167721/clinical-and-radiographic-features-of-pycnodysostosis-a-case-report
#8
Cleomar Rodrigues, Fernando-Antônio Gomes, José-Alcides Arruda, Luciano Silva, Pâmella Álvares, Priscila da Fonte, Ana-Paula Sobral, Marcia Silveira
Pycnodysostosis is a rare disorder that was first described in 1962; however, it was only in 1996 that the defective gene was discovered, which led to a better understanding of this disease. This study reports and discuss a case of pycnodysostosis. In addition, a search of articles published in PubMed-Medline was performed. The case was a 13-year-old girl who was referred to a private clinic for dental treatment. Clinical examination showed midface hypoplasia, prominent cheeks, a high nasal bridge, beaked nose, spoon-shaped fingers, frontal bossing, open fontanelles and dental alterations, findings compatible with pycnodysostosis...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167076/the-convergence-of-two-epidemics-vitamin-d-deficiency-in-obese-school-aged-children
#9
REVIEW
Linda Cheng
PROBLEM: Vitamin D deficiency (VDD) and obesity are two interrelated global epidemics that affect school-aged children. This article will review the relationship between VDD and obesity in school-aged children and implications it has for the pediatric nurse (PN). ELIGIBILITY CRITERIA: Original articles of studies, review articles and meta-analyses were selected from the past 5years and pooled for review. These included obese school-aged children who had vitamin D insufficiency...
October 18, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29165688/management-of-odontoid-fractures-in-the-elderly-a-review-of-the-literature-and-an-evidence-based-treatment-algorithm
#10
Sravisht Iyer, R John Hurlbert, Todd J Albert
Odontoid fractures are the most common fracture of the axis and the most common cervical spine fracture in patients over 65. Despite their frequency, there is considerable ambiguity regarding optimal management strategies for these fractures in the elderly. Poor bone health and medical comorbidities contribute to increased surgical risk in this population; however, nonoperative management is associated with a risk of nonunion or fibrous union. We provide a review of the existing literature and discuss the classification and evaluation of odontoid fractures...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29165309/clinical-characteristics-of-patients-with-dizziness-after-motor-vehicle-accident
#11
Min Bum Kim, Suk Won Chang, Gil Chai Lim, Chan Il Song
OBJECTIVE: The purpose of this study was to identify the clinical characteristics of dizziness occurring after a motor vehicle accident. MATERIALS AND METHODS: We retrospectively analyzed 217 patients who had visited a tertiary medical center complaining of dizziness after a motor vehicle accident between January 2009 and December 2014. Of the 217 patients, we enrolled 54 patients who had undergone a vestibular function test and had no definite evidence of fracture of the temporal bone or intracranial lesions...
November 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29165039/determination-of-a-tissue-level-failure-evaluation-standard-for-rat-femoral-cortical-bone-utilizing-a-hybrid-computational-experimental-method
#12
Ruoxun Fan, Jie Liu, Zhengbin Jia, Ying Deng, Jun Liu
Macro-level failure in bone structure could be diagnosed by pain or physical examination. However, diagnosing tissue-level failure in a timely manner is challenging due to the difficulty in observing the interior mechanical environment of bone tissue. Because most fractures begin with tissue-level failure in bone tissue caused by continually applied loading, people attempt to monitor the tissue-level failure of bone and provide corresponding measures to prevent fracture. Many tissue-level mechanical parameters of bone could be predicted or measured; however, the value of the parameter may vary among different specimens belonging to a kind of bone structure even at the same age and anatomical site...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29165015/lessons-learned-from-volar-plate-fixation-of-scaphoid-fracture-nonunions
#13
Seth D Dodds, John B Williams, Max Seiter, Clark Chen
Treating scaphoid nonunions presents difficulties particularly when there is bone loss, significant humpback deformity or avascular necrosis. We describe a new type of fixation with a volar scaphoid plate that adds to the methods of internal fixation that are available for the treatment of recalcitrant scaphoid nonunions. We will also discuss 'lessons learned' from a cases series. The case series includes 20 consecutive patients treated with volar buttress plating and a pedicled vascularized bone graft from the ipsilateral volar distal radius...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29165014/fixation-of-proximal-pole-scaphoid-nonunion-with-non-vascularized-cancellous-autograft
#14
Timothy J Luchetti, Allison J Rao, John J Fernandez, Mark S Cohen, Robert W Wysocki
We present 20 patients with established proximal pole scaphoid nonunions treated with curettage and cancellous autograft from the distal radius and screw fixation. Fractures with significant proximal pole fragmentation were excluded. Patients were treated at a mean of 26 weeks after injury (range 12-72). Union occurred in 18 of 20 patients (90%) based on computed tomographic imaging. The two nonunions that did not heal were treated with repeat curettage and debridement and iliac crest bone grafting without revision of fixation...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29164589/mir-214-protects-mc3t3-e1-osteoblasts-against-h2o2-induced-apoptosis-by-suppressing-oxidative-stress-and-targeting-atf4
#15
X-Z Lu, Z-H Yang, H-J Zhang, L-L Zhu, X-L Mao, Y Yuan
OBJECTIVE: Fragility fracture is one of the common complications of osteoporosis. Elevated oxidative stress-induced apoptosis is thought to be one of the unfavorable factors to osteoblastic dysfunction, which increased the risk of bone fracture. However, the molecular mechanisms for oxidative stress-induced osteoblast cells apoptosis still need to be elucidated. This study aims to investigate the protective function of miR-214 in H2O2-induced apoptosis of MC3T3-E1 osteoblasts. MATERIALS AND METHODS: MC3T3-E1 cells were treated with 400 μM H2O2...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164586/functions-of-micrornas-in-osteoporosis
#16
D-W Ge, W-W Wang, H-T Chen, L Yang, X-J Cao
Osteoporosis (OP) is a kind of disease with a 25% incidence, characterized by the bone mass loss, bone microstructure damage, increased bone fragility, and easy fracture. miRNA plays an important regulatory role in the process of bone remodeling, especially in the regulation of differentiation and function of osteoblasts and osteoclasts, and the development and progression of OP and other bone diseases. In the future, it is expected to delay the bone loss and promote the bone remodeling via the overexpression or inhibition of specific miRNAs in specific tissues, thereby treating OP...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164558/rapamycin-facilitates-fracture-healing-through-inducing-cell-autophagy-and-suppressing-cell-apoptosis-in-bone-tissues
#17
Z-Y Yin, J Yin, Y-F Huo, J Yu, L-X Sheng, Y-F Dong
OBJECTIVE: To investigate the changes in cell autophagy and the molecular mechanism of rapamycin affecting the fracture healing. MATERIAL AND METHODS: Sprague-Dawley (SD) rats were used to establish the right femoral shaft fracture models, and then underwent immunofluorescence assay to detect the autophagy level in bone tissues. After model establishment, SD rats were divided into two groups, the control group and the rapamycin group (1 mg/kg/d). Respectively, at the 2nd, 4th, and 6th week, rats were randomly selected from each group for X-ray and Micro-computed tomography (Micro-CT) examinations to determine callus growth, immunofluorescence assay to detect the protein expression of light chain 3 II (LC3 II), immunohistochemistry to evaluate the autophagy level through detecting the expression of Beclin1 in rats, Western blotting assay to detect cell apoptosis in tissues, hematoxylin and eosin staining (HE staining) to evaluate the osteoblastic activity through count of osteoblast in bone tissue at the end of fracture, and measure the expression of vascular endothelial growth factors (VEGF)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164183/removal-of-a-severely-impacted-mandibular-third-molar-minimizing-the-risks-of-compromised-periodontium-nerve-injury-and-mandibular-fracture
#18
Christos Tsamis, Stylianos Rodiou, Athanasios Stratos, Nikolaos Gkantidis
A technique is presented for severely impacted and dentigerous-cyst-related mandibular third molar removal, avoiding any associated risks. CASE PRESENTATION: A healthy patient complained about unpleasant smell and taste in the mouth and unilateral extraoral palpation of a protuberance, at the right corner of the mandible. Restricted field CBCT showed a severely impacted third molar, which penetrated the inferior cortical bone of the mandibular corner and was associated with a dentigerous cyst that had resorbed considerable bone in the region...
November 21, 2017: Quintessence International
https://www.readbyqxmd.com/read/29163183/pharmacological-therapy-of-osteoporosis-a-systematic-current-review-of-literature
#19
REVIEW
Vito Pavone, Gianluca Testa, Serena M C Giardina, Andrea Vescio, Domenico A Restivo, Giuseppe Sessa
Osteoporosis is the most common bone disease affecting millions of people worldwide, particularly in elderly or in post-menopausal women. The pathogenesis is useful to understand the possible mechanism of action of anti-osteoporotic drugs. Early diagnosis, possible with several laboratory and instrumental tests, allows a major accuracy in the choice of anti-osteoporosis drugs. Treatment of osteoporosis is strictly related to severity of pathology and consists on prevention of fragility fractures with a correct lifestyle and adequate nutritional supplements, and use of pharmacological therapy, started in patients with osteopenia and history of fragility fracture of the hip or spine...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162538/metformin-promotes-the-proliferation-and-differentiation-of-murine-preosteoblast-by-regulating-the-expression-of-sirt6-and-oct4
#20
Wei Mu, Zhuoran Wang, Chuanyu Ma, Yunyun Jiang, Nannan Zhang, Kaiqiang Hu, Liyuan Li, Zhao Wang
Osteopenia, osteoporosis and bone salt metabolism disorder are common diseases in the aged and diabetics. From case reports of patients with T2DM, we have observed that metformin can decrease risk of bone fracture and promote bone formation. However, the underlying mechanism of metformin's effect on bone metabolism remains unknown. In our research, we show that metformin can promote proliferation of murine preosteoblast by regulating AMPK-mTORC2 and AKT-mTORC1 signaling axis. Furthermore, we have observed that metformin can promote SIRT6 expression before and during differentiation of murine preosteoblast...
November 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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