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https://www.readbyqxmd.com/read/28107676/characterization-of-a-new-ultrasound-device-designed-for-measuring-cortical-porosity-at-the-human-tibia-a-phantom-study
#1
M Gräsel, C-C Glüer, R Barkmann
Quantitative ultrasound (QUS) measurements of trabecular bone are a useful tool for the assessment of osteoporotic fracture risk. However, cortical bone properties (e.g. porosity) have an impact on bone strength as well and thus current research is focused on QUS assessment of cortical bone properties. Simulation studies of ultrasound propagation through cortical bone indicate that anisotropy, calculated from the ratio of the velocities in axial and tangential directions, is correlated with porosity. However, this relationship is affected by error sources, specifically bone surface curvature and variability of probe positioning...
January 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28107241/polytrauma-patients-with-associated-spine-fractures-an-assessment-of-surgical-intervention-on-patient-outcome
#2
Steven R Niedermeier, Safdar N Khan
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To examine perioperative characteristics among polytraumatized patients with operative, unstable spine fractures with and without concomitant operative long bone injuries. SUMMARY OF BACKGROUND DATA: Treatment of polytrauma patients has delicate and time-sensitive protocols to ensure successful recovery. The literature defines standards for vertebral injury and surgical intervention...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107240/an-in-vitro-evaluation-of-fracture-reduction-achieved-by-inflatable-bone-tamps-under-simulated-physiological-load
#3
Michael Gordon, Walter C Peppelman, William Beutler, Damien OʼHalloran, Suresh R Chinthakunta, Brandon Bucklen
STUDY DESIGN: An in vitro biomechanical study. OBJECTIVE: To determine the fracture reduction achieved by a novel inflatable bone tamp under simulated physiological load. SUMMARY OF BACKGROUND DATA: Previous biomechanical studies have showed that kyphoplasty allows near-total restoration of lost vertebral height in unloaded conditions and partial height restoration under simulated physiological loads. Clinically, loss of reduction has been observed after bone tamp deflation, before cement injection...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106724/osteocalcin-mediates-biomineralization-during-osteogenic-maturation-in-human-mesenchymal-stromal-cells
#4
Yu-Tzu Tsao, Yi-Jeng Huang, Hao-Hsiang Wu, Yu-An Liu, Yi-Shiuan Liu, Oscar K Lee
There is a growing interest in cell therapies using mesenchymal stromal cells (MSCs) for repairing bone defects. MSCs have the ability to differentiate into osteoprogenitors and osteoblasts as well as to form calcified bone matrix. However, the molecular mechanisms governing mineralization during osteogenic differentiation remain unclear. Non-collagenous proteins in the extracellular matrix are believed to control different aspects of the mineralization. Since osteocalcin is the most abundant non-collagenous bone matrix protein, the purpose of this study is to investigate the roles of osteocalcin in mineral species production during osteogenesis of MSCs...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106705/repair-of-orbital-floor-fracture-with-modified-transnasal-endoscopic-approach-through-anterior-space-to-nasolacrimal-duct
#5
Motohiko Suzuki, Yoshihisa Nakamura, Shinya Ozaki, Makoto Yokota, Shingo Murakami
OBJECTIVES: Endoscopic approach provides excellent magnification and visualization, and a purely transnasal approach is minimally invasive method. However, it is very difficult to repair anterior and lateral fractures with the previous transnasal endoscopic approaches, since repair of orbital fractures is managed through the middle meatus and ostium from the posterior side of the nasolacrimal duct with side-viewing endoscope and curved instruments. Therefore, the authors used modified transnasal endoscopic approach as an alternative for repair of orbital floor fractures in order to effectively reach the lateral or anterior fracture of the orbital floor with straight endoscope and instruments endoscopically...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106692/use-of-resorbable-fixation-system-in-pediatric-facial-fractures
#6
Frankie K Wong, Saleigh Adams, Donald A Hudson, Wayne Ozaki
INTRODUCTION: Resorbable fixation system (RFS) is an alternative to titanium in open reduction and internal fixation of pediatric facial fractures. METHODS: This study retrospectively reviewed all medical records in a major metropolitan pediatric hospital in Cape Town, South Africa from September 2010 through May 2014. Inclusion criteria were children under the age of 13 with facial fractures who have undergone open reduction and internal fixation using RFS. Intraoperative and postoperative complications were reviewed...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106229/the-rm-pressfit-vitamys-5-year-swiss-experience-of-the-first-100-cups
#7
Michael Wyatt, Jan Weidner, Dominik Pfluger, Martin Beck
BACKGROUND: The RM Pressfit vitamys is a titanium particle-coated monoblock cup with vitamin E stabilised highly cross-linked polyethylene. Initial fixation is achieved via press-fit with subsequent stability by bone on-growth. This is the first study to report the 5-year results of this design. METHODS: We performed a prospective cohort study according to STROBE guidelines of 100 consecutive total hip replacements (THRs) in 92 patients all with ceramic heads. Demographic data, pre/postoperative visual analogue scale (VAS) for pain and satisfaction, Harris Hip Scores (HHS) and complications were recorded...
January 20, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#8
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28105580/pixel-based-dxa-derived-structural-properties-strongly-correlate-with-pqct-measures-at-the-one-third-distal-femur-site
#9
Alexander M Baker, David W Wagner, B Jenny Kiratli, Gary S Beaupre
While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unlike DXA scanners, are rarely found in clinical settings. Using fifty-four fresh frozen femora, we developed and validated a pixel-by-pixel method to calculate engineering properties at the distal femur using a Hologic QDR-1000 W DXA scanner and compared them against similar parameters measured using a Stratec XCT-3000 peripheral QCT scanner...
January 19, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28105511/bone-density-in-the-obese-child-clinical-considerations-and-diagnostic-challenges
#10
Jennifer C Kelley, Nicola Crabtree, Babette S Zemel
The prevalence of obesity in children has reached epidemic proportions. Concern about bone health in obese children, in part, derives from the potentially increased fracture risk associated with obesity. Additional risk factors that affect bone mineral accretion, may also contribute to obesity, such as low physical activity and nutritional factors. Consequences of obesity, such as inflammation, insulin resistance, and non-alcoholic fatty liver disease, may also affect bone mineral acquisition, especially during the adolescent years when rapid increases in bone contribute to attaining peak bone mass...
January 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28105502/transfracture-medial-transposition-of-the-radial-nerve-associated-with-plate-fixation-of-the-humerus
#11
Ali Hassan Chamseddine, Amer Abdallah, Hadi Zein, Assad Taha
PURPOSE: The aim of this study was to illustrate safety, feasibility and advantages of transfracture medial transposition of the radial nerve during the lateral approach and lateral plating of humeral fractures located in the mid and distal shaft. METHODS: This was a retrospective review and analysis of medical records and radiographs of 19 patients who underwent a transfracture medial transposition of the radial nerve. Fifteen patients were treated for fresh fracture and four for nonunion...
January 19, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28105126/hmgb1-promotes-the-secretion-of-multiple-cytokines-and-potentiates-the-osteogenic-differentiation-of-mesenchymal-stem-cells-through-the-ras-mapk-signaling-pathway
#12
Lin Feng, Deting Xue, Erman Chen, Wei Zhang, Xiang Gao, Jiawei Yu, Yadong Feng, Zhijun Pan
High mobility group box 1 (HMGB1) protein has been previously been detected in the inflammatory microenvironment of bone fractures. It is well known that HMGB1 acts as a chemoattractant to mesenchymal stem cells (MSCs). In the present study, the effects of HMGB1 on cytokine secretion from MSCs were determined, and the molecular mechanisms underlying these effects of HMGB1 on osteogenic differentiation were elucidated. To detect cytokine secretion, antibody array assays were performed, which demonstrated that HGMB1 induced the differential secretion of cytokines that are predominantly associated with cell development, regulation of growth and cell migration, stress responses, and immune system functions...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28105092/serum-n-terminal-telopeptide-of-type-i-collagen-as-an-early-marker-of-fracture-nonunion-in-rabbits
#13
Jian-Ping Lin, Zhan-Jun Shi, Ning-Jiang Shen, Jian Wang, Zao-Min Li, Jun Xiao
The aim of the present study was to establish an experimental animal model of fracture nonunion, and to investigate the changes in serum biomarker concentrations in fracture nonunion. A total of 20 purebred New Zealand rabbits were divided into two group: A bone defect group and a bone fracture group. In the bone defect group, a 15-mm section of bone (including the periosteum) was removed from the mid-radius, and the medullary cavities were closed with bone wax. In the bone fracture group, the mid-radius was fractured...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28105080/current-practice-of-antibiotic-prophylaxis-for-surgical-fixation-of-closed-long-bone-fractures-a-survey-of-297-members-of-the-orthopaedic-trauma-association
#14
Itai Gans, Amit Jain, Norachart Sirisreetreerux, Elliott R Haut, Erik A Hasenboehler
BACKGROUND: The risk of postoperative surgical site infection after long bone fracture fixation can be decreased with appropriate antibiotic use. However, there is no agreement on the superiority of a single- or multiple-dose perioperative regimen of antibiotic prophylaxis. The purpose of this study is to determine the following: 1) What are the current practice patterns of orthopaedic trauma surgeons in using perioperative antibiotics for closed long bone fractures? 2) What is the current knowledge of published antibiotic prophylaxis guidelines among orthopaedic trauma surgeons? 3) Are orthopaedic surgeons willing to change their current practices? METHODS: A questionnaire was distributed via email between September and December 2015 to 955 Orthopaedic Trauma Association members, of whom 297 (31%) responded...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28104509/morphometric-vertebral-fractures-in-breast-cancer-patients-treated-with-adjuvant-aromatase-inhibitor-therapy-a-cross-sectional-study
#15
Rebecca Pedersini, Sara Monteverdi, Gherardo Mazziotti, Vito Amoroso, Elisa Roca, Filippo Maffezzoni, Lucia Vassalli, Filippo Rodella, Anna Maria Formenti, Stefano Frara, Roberto Maroldi, Alfredo Berruti, Edda Simoncini, Andrea Giustina
BACKGROUND: The impact of long-term adjuvant therapy with aromatase inhibitors (AIs) on vertebral fracture (VF) risk is still unclear. OBJECTIVE: In this cross-sectional study, we explored the prevalence and determinants of VFs in breast cancer (BC) patients before and during AI therapy. Each woman underwent a dual-energy X-ray absorptiometry (DXA) to evaluate bone mineral density (BMD) and identify VFs by a quantitative morphometric approach. Blood samples were collected to measure serum hormone and calcium levels...
January 16, 2017: Bone
https://www.readbyqxmd.com/read/28103901/pathogenic-lrrk2-variants-are-gain-of-function-mutations-that-enhance-lrrk2-mediated-repression-of-%C3%AE-catenin-signaling
#16
Daniel C Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A Pitsillides, Kirsten Harvey
BACKGROUND: LRRK2 mutations and risk variants increase susceptibility to inherited and idiopathic Parkinson's disease, while recent studies have identified potential protective variants. This, and the fact that LRRK2 mutation carriers develop symptoms and brain pathology almost indistinguishable from idiopathic Parkinson's disease, has led to enormous interest in this protein. LRRK2 has been implicated in a range of cellular events, but key among them is canonical Wnt signalling, which results in increased levels of transcriptionally active β-catenin...
January 19, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28103859/treatment-with-soluble-activin-type-iib-receptor-improves-bone-mass-and-strength-in-a-mouse-model-of-duchenne-muscular-dystrophy
#17
Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J Hulmi, Riku Kiviranta
BACKGROUND: Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle degeneration and also high incidence of fractures. The aim of our study was to test whether inhibition of activin receptor IIB ligands with or without exercise could improve bone strength in the mdx mouse model for DMD. METHODS: Thirty-two mdx mice were divided to running and non-running groups and to receive either PBS control or soluble activin type IIB-receptor (ActRIIB-Fc) once weekly for 7 weeks...
January 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28103852/stiffness-of-the-locking-compression-plate-as-an-external-fixator-for-treating-distal-tibial-fractures-a-biomechanics-study
#18
Wei Liu, Lihui Yang, Xiaochuan Kong, Likun An, Gang Hong, Zicheng Guo, Lei Zang
BACKGROUND: Locking compress plate, as external fixator, is an attractive technique for distal tibial fracture treatment. But it still remains unclear whether the external LCP has sufficient stiffness. Thus, the present study aims to make a comprehensive evaluation of the stiffness of external locking compress plate when it is used as an external fixator in distal tibial fractures treatment. METHODS: Composite tibia was used to simulate distal tibia fracture (Orthopedic Trauma Association type 43 A3 fracture)...
January 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28103515/strong-synergistic-effects-in-pla-pcl-blends-impact-of-pla-matrix-viscosity
#19
Aleksandra Ostafinska, Ivan Fortelný, Jiří Hodan, Sabina Krejčíková, Martina Nevoralová, Jana Kredatusová, Zdeněk Kruliš, Jiří Kotek, Miroslav Šlouf
Blends of two biodegradable polymers, poly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL), with strong synergistic improvement in mechanical performance were prepared by melt-mixing using the optimized composition (80/20) and the optimized preparation procedure (a melt-mixing followed by a compression molding) according to our previous study. Three different PLA polymers were employed, whose viscosity decreased in the following order: PLC ≈ PLA1 > PLA2 > PLA3. The blends with the highest viscosity matrix (PLA1/PCL) exhibited the smallest PCL particles (d∼0...
January 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28102457/prevalence-of-vertebral-fracture-and-densitometric-osteoporosis-in-spanish-adult-men-the-camargo-cohort-study
#20
José M Olmos, José L Hernández, Josefina Martínez, Emilio Pariente, Jesús Castillo, Daniel Prieto-Alhambra, Jesús González-Macías
The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA at the lumbar spine, femoral neck and total hip. Vertebral fractures were assessed by lateral thoracic and lumbar spine radiographs. The prevalence of osteoporosis was estimated with both the World Health Organization (WHO) (T-score of <-2...
January 19, 2017: Journal of Bone and Mineral Metabolism
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