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https://www.readbyqxmd.com/read/29310594/the-impact-of-cathelicidin-the-human-antimicrobial-peptide-ll-37-in-urinary-tract-infections
#1
Ibrahim H Babikir, Elsir A Abugroun, Naser Eldin Bilal, Abdullah Ali Alghasham, Elmuataz Elmansi Abdalla, Ishag Adam
BACKGROUND: The defense mechanisms of the urinary tract are attributed mainly to the innate immune system and the urinary tract urothelium which represent the first line of defense against invading pathogens and maintaining sterility of the urinary tract. There are only a few publications regarding cathelicidin (LL-37) and a urinary tract infection (UTI). This study was done to investigate the plasma and urine levels of human LL-37 in patients with UTI. METHODS: A case-control study was conducted at Omdurman Hospital, Sudan during the period from August 2014 to May 2017...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29282543/characterization-of-bactericidal-efficiency-cell-selectivity-and-mechanism-of-short-interspecific-hybrid-peptides
#2
N Dong, X R Li, X Y Xu, Y F Lv, Z Y Li, A S Shan, J L Wang
Facing rising global antibiotics resistance, physical membrane-damaging antimicrobial peptides (AMPs) represent promising antimicrobial agents. Various strategies to design effective hybrid peptides offer many advantages in overcoming the adverse effects of natural AMPs. In this study, hybrid peptides from different species were investigated, and three hybrid antimicrobial peptides, LI, LN, and LC, were designed by combining the typical fragment of human cathelicidin-derived LL37 with either indolicidin, pig nematode cecropin P1 (CP-1) or rat neutrophil peptide-1 (NP-1)...
December 27, 2017: Amino Acids
https://www.readbyqxmd.com/read/29274013/fermented-soybean-meal-increases-lactic-acid-bacteria-in-gut-microbiota-of-atlantic-salmon-salmo-salar
#3
Natalia Catalán, Alejandro Villasante, Jurij Wacyk, Carolina Ramírez, Jaime Romero
The main goal of the present study was to address the effect of feeding fermented soybean meal-based diet to Atlantic salmon on gut microbiota. Further, expression of genes of interest, including cathelicidin antimicrobial peptide (cath), mucin 2 (muc2), aquaporin (aqp8ab), and proliferating cell nuclear antigen (pcna), in proximal intestine of fish fed either experimental diet was analyzed. Three experimental diets, including a control fishmeal (30% FM), soybean meal (30% SBM), or fermented soybean meal diet (30% FSBM) were randomly assigned to triplicate tanks during a 50-day trial...
December 22, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29242830/interaction-of-antibiotics-with-innate-host-defense-factors-against-salmonella-enterica-serotype-newport
#4
George Sakoulas, Monika Kumaraswamy, Armin Kousha, Victor Nizet
This study examines the pharmacodynamics of antimicrobials that are used to treat Salmonella with each other and with key components of the innate immune system. Antimicrobial synergy was assessed using time-kill and checkerboard assays. Antimicrobial interactions with innate immunity were studied by employing cathelicidin LL-37, whole-blood, and neutrophil killing assays. Ceftriaxone and ciprofloxacin were found to be synergistic in vitro against Salmonella enterica serotype Newport. Ceftriaxone, ciprofloxacin, and azithromycin each demonstrated synergy with the human cathelicidin defense peptide LL-37 in killing Salmonella...
November 2017: MSphere
https://www.readbyqxmd.com/read/29239826/circulating-cathelicidin-ll-37-level-is-increased-in-euthymic-patients-with-bipolar-disorder
#5
Elżbieta Kozłowska, Paulina Żelechowska, Ewa Brzezińska-Błaszczyk, Aleksandra Margulska, Adam Wysokiński
More and more data seems to imply that immune mechanisms are involved in the pathomechanism of bipolar disorder (BD). However, the primary role of cathelicidin LL-37 is defense against pathogens, more and more data indicated that this peptide strongly modulates immune system functioning and contributes to immune pathology of chronic and inflammatory diseases. No data is available on the level of LL-37 in bipolar patients. The aim of the study was to examine the circulating levels of cathelicidin LL-37 in euthymic patients with BD...
November 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29223308/what-we-have-lost-mastitis-resistance-in-holstein-friesians-and-in-a-local-cattle-breed
#6
Giulio Curone, Joel Filipe, Paola Cremonesi, Erminio Trevisi, Massimo Amadori, Claudia Pollera, Bianca Castiglioni, Lauretta Turin, Vittorio Tedde, Daniele Vigo, Paolo Moroni, Andrea Minuti, Valerio Bronzo, M Filippa Addis, Federica Riva
In Holstein Friesian dairy cows, selective pressure for increased milk production has led to a higher propensity to disease, including mastitis, when compared to less selected and lower producing dairy breeds. The biology underpinning the higher resistance to disease of such "local breeds" is not fully understood. With the aim of investigating the factors associated to this phenomenon, we applied a multidisciplinary approach to compare innate immune response patterns, metabolic parameters, milk protein profiles and the milk microbiota in Holstein Friesian and Rendena cows reared in the same farm and under the same management conditions...
November 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29223160/cathelicidin-ll37-promotes-epithelial-and-smooth-muscle-like-differentiation-of-adipose-derived-stem-cells-through-the-wnt-%C3%AE-catenin-and-nf-%C3%AE%C2%BAb-pathways
#7
Yongwei Li, Zhengfei Shan, Bin Yang, Diandong Yang, Changping Men, Yuanshan Cui, Jitao Wu
Ureter reconstruction is a difficult procedure in urology. Adipose-derived stem cells (ADSCs), along with multipotency and self-renewal capacity, are a preferred choice for tissue engineering-based ureteral reconstruction. We explored the synergic role of cathelicidin LL37 (LL37) in epithelial and smooth-muscle-like differentiation. ADSCs were separated from adipose tissues of mouse and characterized by flow cytometry. The ADSCs were then stably transfected with pGC-FU-GFP (pGC) or pGC containing full-length LL37 (pGC-LL37), respectively...
November 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29222824/elevated-levels-of-the-antimicrobial-peptide-ll-37-in-hidradenitis-suppurativa-are-associated-with-a-th1-th17-immune-response
#8
R Thomi, C Schlapbach, N Yawalkar, D Simon, D Yerly, R E Hunger
Hidradenitis suppurativa (HS) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL-37 is an antimicrobial peptide, which is transcribed from the CAMP (cathelicidin antimicrobial peptide) gene. Previous reports showed upregulated levels of CAMP and LL-37 in HS lesions and therefore the aim of this study was to compare levels of LL-37 in HS to other inflammatory skin diseases and to establish immunomodulatory functions of LL-37 in HS. We confirm an upregulation of the LL-37 peptide in lesional HS skin with comparable levels as in psoriasis patients and are able to positively correlate the presence of LL-37 in HS with the presence of T cells, macrophages, neutrophils, IFNγ, IL-17, IL-23, TNFα, IL-32 and IL-1β...
December 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29221882/effective-inhibition-of-cbf-14-against-cryptococcus-neoformans-infection-in-mice-and-its-related-anti-inflammatory-activity
#9
Changzhong Yu, Shanshan Wei, Xiaorong Han, Hanhan Liu, Mengxiao Wang, Meiling Jiang, Min Guo, Jie Dou, Changlin Zhou, Lingman Ma
Cbf-14 (RLLRKFFRKLKKSV), a designed peptide derived from cathelicidin family AMP, has proven to be potent against drug-resistant bacteria. In the present study, we investigated the anti-cryptococcal activity of Cbf-14 in vitro and in a pulmonary infection mouse model. Sensitivity test indicated that Cbf-14 possessed effective antifungal activity against Cryptococcus neoformans with an MIC of 4-16 µg/ml, and killing experiments showed that fungicidal activity was achieved after only 4 h treatment with Cbf-14 at 4× MIC concentrations in vitro...
December 5, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29214974/insights-into-the-candidacidal-mechanism-of-ctn-15-34-a-carboxyl-terminal-crotalicidin-derived-peptide-related-to-cathelicidins
#10
Carolina Sidrim P Cavalcante, Francisca Lidiane Linhares de Aguiar, Raquel O S Fontenelle, Ramon Roseo de P P B de Menezes, Alice Maria Costa Martins, Cláudio B Falcão, David Andreu, Gandhi Rádis-Baptista
PURPOSE: Ctn[15-34], a carboxyl-terminal fragment of crotalicidin (a cathelicidin from the venom gland of a South American rattlesnake), has shown antifungal activity against clinical and standard strains of Candida species. The aim of the present work was to investigate the underlying mechanisms of the candidicidal activity of Ctn[15-34]. METHODOLOGY: The time-kill profile and drug synergism were evaluated by means of a microdilution assay and multi-parametric flow cytometry...
December 7, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29208061/antichagasic-effect-of-crotalicidin-a-cathelicidin-like-vipericidin-found-in-crotalus-durissus-terrificus-rattlesnake-s-venom-gland
#11
Izabel Cristina Justino Bandeira, Danya Bandeira-Lima, Clarissa Perdigão Mello, Ticiana Praciano Pereira, Ramon Róseo Paula Pessoa Bezerra De Menezes, Tiago Lima Sampaio, Cláudio Borges Falcão, Gandhi Rádis-Baptista, Alice Maria Costa Martins
Cathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the South American Crotalus durissus terrificus rattlesnake's venom gland, and its fragments have demonstrated antimicrobial and antifungal activity, similarly to human cathelicidin LL-37. In order to provide templates for the development of modern trypanocidal agents, the present study evaluated the antichagasic effect of these four peptides (Ctn, Ctn[1-14], Ctn[15-34] and LL-37)...
December 6, 2017: Parasitology
https://www.readbyqxmd.com/read/29206168/significance-and-diagnostic-role-of-antimicrobial-cathelicidins-ll-37-peptides-in-oral-health
#12
REVIEW
Zohaib Khurshid, Mustafa Naseem, Faris Yahya I Asiri, Maria Mali, Rabia Sannam Khan, Haafsa Arshad Sahibzada, Muhammad Sohail Zafar, Syed Faraz Moin, Erum Khan
Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity...
December 5, 2017: Biomolecules
https://www.readbyqxmd.com/read/29204370/association-of-vitamin-d-with-cathelicidin-and-vitamin-d-binding-protein-in-pediatric-sepsis
#13
Emily Mathias, Vin Tangpricha, Ajit Sarnaik, Ahmad Farooqi, Usha Sethuraman
No abstract text is available yet for this article.
December 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29180648/csa13-inhibits-colitis-associated-intestinal-fibrosis-via-a-formyl-peptide-receptor-like-1-mediated-hmg-coa-reductase-pathway
#14
Chunlan Xu, Sally Ghali, Jiani Wang, David Q Shih, Christina Ortiz, Caroline C Mussatto, Elaine C Lee, Diana H Tran, Jonathan P Jacobs, Venu Lagishetty, Phillip Fleshner, Lori Robbins, Michelle Vu, Tressia C Hing, Dermot P B McGovern, Hon Wai Koon
Many Crohn's disease (CD) patients develop intestinal strictures, which are difficult to prevent and treat. Cationic steroid antimicrobial 13 (CSA13) shares cationic nature and antimicrobial function with antimicrobial peptide cathelicidin. As many functions of cathelicidin are mediated through formyl peptide receptor-like 1 (FPRL1), we hypothesize that CSA13 mediates anti-fibrogenic effects via FPRL1. Human intestinal biopsies were used in clinical data analysis. Chronic trinitrobenzene sulfonic acid (TNBS) colitis-associated intestinal fibrosis mouse model with the administration of CSA13 was used...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173590/gene-expression-profiling-of-chicken-cecal-tonsils-and-ileum-following-oral-exposure-to-soluble-and-plga-encapsulated-cpg-odn-and-lysate-of-campylobacter-jejuni
#15
Khaled Taha-Abdelaziz, Tamiru Negash Alkie, Douglas C Hodgins, Alexander Yitbarek, Bahram Shojadoost, Shayan Sharif
Campylobacter jejuni (C. jejuni) is a leading bacterial cause of food-borne illness in humans. Contaminated chicken meat is an important source of infection for humans. Chickens are not clinically affected by colonization, and immune responses following natural infection have limited effects on bacterial load in the gut. Induction of intestinal immune responses may possibly lead to a breakdown of the commensal relationship of chickens with Campylobacter. We have recently shown that soluble and poly D, L-lactic-co-glycolic acid (PLGA)-encapsulated CpG oligodeoxynucleotide (ODN) as well as C...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29172482/amino-terminal-copper-and-nickel-binding-motif-derivatives-of-ovisprin-3-display-increased-antimicrobial-activity-via-lipid-oxidation
#16
Jessica L Alexander, Zhen Yu, James A Cowan
Antimicrobial peptides are short peptides secreted by the innate immune system to protect the host from pathogens. We have investigated the influence of the amino terminal copper and nickel binding (ATCUN) motif on derivatives of ovispirin-3 (OV-3), an α-helical peptide from the cathelicidin family, demonstrating increased antimicrobial activity towards a broad range of bacteria, relative to OV-3, with MICs as low as 1.3±0.6 µM. Each peptide was able to bind DNA and RNA with micromolar affinity, but did not display nuclease activity in vivo...
November 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29169409/characteristic-pro-inflammatory-cytokines-and-host-defence-cathelicidin-peptide-produced-by-human-monocyte-derived-macrophages-infected-with-neospora-caninum
#17
E Boucher, M Marin, R Holani, M Young-Speirs, D M Moore, E R Cobo
Neospora caninum is a coccidian intracellular protozoan capable of infecting a wide range of mammals, although severe disease is mostly reported in dogs and cattle. Innate defences triggered by monocytes/macrophages are key in the pathogenesis of neosporosis, as these cells are first-line defenders against intracellular infections. The aim of this study was to characterize infection and innate responses in macrophages infected with N. caninum using a well-known cell model to study macrophage functions (human monocyte THP-1 cells)...
November 24, 2017: Parasitology
https://www.readbyqxmd.com/read/29164103/the-human-antimicrobial-peptides-dermcidin-and-ll-37-show-novel-distinct-pathways-in-membrane-interactions
#18
REVIEW
Kornelius Zeth, Enea Sancho-Vaello
Mammals protect themselves from inflammation triggered by microorganisms through secretion of antimicrobial peptides (AMPs). One mechanism by which AMPs kill bacterial cells is perforating their membranes. Membrane interactions and pore formation were investigated for α-helical AMPs leading to the formulation of three basic mechanistic models: the barrel stave, toroidal, and carpet model. One major drawback of these models is their simplicity. They do not reflect the real in vitro and in vivo conditions. To challenge and refine these models using a structure-based approach we set out to investigate how human cathelicidin (LL-37) and dermcidin (DCD) interact with membranes...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29164074/systemic-responses-of-multidrug-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-following-exposure-to-the-antimicrobial-peptide-cathelicidin-bf-imply-multiple-intracellular-targets
#19
Cunbao Liu, Bin Shan, Jialong Qi, Yanbing Ma
Cathelicidin-BF, derived from the banded krait (Bungarus fasciatus), is a typically cationic, amphiphilic and α-helical antimicrobial peptide (AMP) with 30 amino acids that exerts powerful effects on multidrug-resistant (MDR) clinical isolates, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, but whether it targets plasma membranes or intracellular targets to kill bacteria is still controversial. In the present study, we demonstrated that the disruption of bacterial membranes with high concentrations of cathelicidin-BF was the cause of bacterial death, as with conventional antibiotics at high concentrations...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29160535/an-investigation-of-human-beta-defensins-and-cathelicidin-expression-in-patients-with-pterygium
#20
Remzi Karadag, Nurettin Bayram, Serpil Oguztuzun, Huseyin Bayramlar, Busra Bozer, Gulcin Simsek, Christopher J Rapuano
PURPOSE: To investigate human beta-defensins (HBDs) and cathelicidin LL-37 (LL-37) expressions in patients with pterygium. METHODS: In this retrospective consecutive case series, 26 pterygium specimens and 15 normal conjunctival specimens of 15 control subjects were in vestigated. Expressions of HBD-1, HBD-2, HBD-3, and LL-37 were assessed using immuno histochemical staining. A brown color in the cytoplasm and/or nuclei of epithelial cells indicated positive staining for HBDs and LL-37...
September 2017: Arquivos Brasileiros de Oftalmologia
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