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https://www.readbyqxmd.com/read/28329895/using-a-state-birth-registry-as-a-quality-improvement-tool
#1
Carole Lannon, Heather C Kaplan, Kelly Friar, Sandra Fuller, Susan Ford, Beth White, John Besl, John Paulson, Michael Marcotte, Michael Krew, Jennifer Bailit, Jay Iams
Background Birth registry data are universally collected, generating large administrative datasets. However, these data are typically not used for quality improvement (QI) initiatives in perinatal medicine because the quality and timeliness of the information is uncertain. Objective We sought to identify and address causes of inaccuracy in recording birth registry information so that birth registry data could support statewide obstetrical quality initiatives in Ohio. Study Design The Ohio Perinatal Quality Collaborative and the Ohio Department of Health Vital Statistics used QI techniques in 15 medium-sized maternity hospitals to identify and remove systemic sources of inaccuracy in birth registry data...
March 22, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28328955/treatment-monitoring-in-metastatic-colorectal-cancer-patients-by-quantification-and-kras-genotyping-of-circulating-cell-free-dna
#2
Andreas W Berger, Daniel Schwerdel, Hanna Welz, Ralf Marienfeld, Stefan A Schmidt, Alexander Kleger, Thomas J Ettrich, Thomas Seufferlein
Treatment of metastatic colorectal cancer (CRC) has continuously improved over the last decade. However, disease monitoring remains underdeveloped and mostly dependent on imaging e.g. RECIST 1.1 criteria. The genetic landscape of individual cancers and subsequently occurring treatment-induced evolution remain neglected in current surveillance strategies. Novel biomarkers demand minimally invasive and repetitive tracking of the cancer mutagenome for therapy stratification and to make prognostic predictions. Carcinoembryonic antigen (CEA), a routinely used tumor marker for CRC, does not meet these goals and thus prevents its use as a reliable monitoring tool...
2017: PloS One
https://www.readbyqxmd.com/read/28325771/estimating-prevalence-trends-in-adult-gonorrhoea-and-syphilis-in-low-and-middle-income-countries-with-the-spectrum-sti-model-results-for-zimbabwe-and-morocco-from-1995-to-2016
#3
Eline L Korenromp, Guy Mahiané, Jane Rowley, Nico Nagelkerke, Laith Abu-Raddad, Francis Ndowa, Amina El-Kettani, Houssine El-Rhilani, Philippe Mayaud, R Matthew Chico, Carel Pretorius, Kendall Hecht, Teodora Wi
OBJECTIVE: To develop a tool for estimating national trends in adult prevalence of sexually transmitted infections by low- and middle-income countries, using standardised, routinely collected programme indicator data. METHODS: The Spectrum-STI model fits time trends in the prevalence of active syphilis through logistic regression on prevalence data from antenatal clinic-based surveys, routine antenatal screening and general population surveys where available, weighting data by their national coverage and representativeness...
March 21, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28323153/application-and-development-of-a-taqman-real-time-pcr-for-detecting-infectious-spleen-and-kidney-necrosis-virus-in-siniperca-chuatsi
#4
Qiang Lin, Xiaozhe Fu, Lihui Liu, Hongru Liang, Huizhi Guo, Shuwen Yin, Venkatesh Kumaresan, Zhibin Huang, Ningqiu Li
Infectious spleen and kidney necrosis virus (ISKNV) is one of the major epidemiological agents that had caused great economic loss in Chinese perch (Siniperca chuatsi). In this study, a specific TaqMan real-time PCR was developed using a pair of primers and a TaqMan probe specific to the ORF007 gene of ISKNV to rapidly detect ISKNV copies in Chinese perch samples. This assay was optimized to produce linearity from 8.75 × 10(8) to 8.75 × 10(1) copies in standard curve with an efficiency of 98% and a R(2) value of 0...
March 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28318462/the-epidemiology-of-operation-stress-during-continuing-promise-2011-a-humanitarian-response-and-disaster-relief-mission-aboard-a-us-navy-hospital-ship
#5
William T Scouten, Melissa L Mehalick, Elizabeth Yoder, Andrea McCoy, Tracy Brannock, Mark S Riddle
Introduction Operational stress describes individual behavior in response to the occupational demands and tempo of a mission. The stress response of military personnel involved in combat and peace-keeping missions has been well-described. The spectrum of effect on medical professionals and support staff providing humanitarian assistance, however, is less well delineated. Research to date concentrates mainly on shore-based humanitarian missions. Problem The goal of the current study was to document the pattern of operational stress, describe factors responsible for it, and the extent to which these factors impact job performance in military and civilian participants of Continuing Promise 2011 (CP11), a ship-based humanitarian medical mission...
March 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28317069/deciphering-the-role-of-ectosomes-in-cancer-development-and-progression-focus-on-the-proteome
#6
REVIEW
Magdalena Surman, Ewa Stępień, Dorota Hoja-Łukowicz, Małgorzata Przybyło
Ectosomes are small heterogeneous membrane vesicles generated by budding from the plasma membrane in a variety of cell types and, more frequently, in tumor cells. They are shed into the extracellular space and are proposed as a novel form of intracellular communication in which information is transmitted from the originating cell to recipient cells without direct cell-to-cell contact. This review focuses on a single population of extracellular vesicles-ectosomes. We summarize recent studies of tumor-derived ectosomes which examine their biogenesis and protein cargo, and their influence on different aspects of cancer progression...
March 19, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28315144/monitoring-antimicrobial-resistance-amr-using-cusum-control-charts
#7
L Righi, R Amarsy, M-Q Picat, M Thuillier, E Cambau, L Raskine, S Chevret, R Flicoteaux
We evaluated the use of the Cumulative Summation (CUSUM) control chart methodology for detection of an excessive increase in antimicrobial-resistant (AMR) bacteria acquisition. We used administrative, clinical and bacteriological data from all 157,570 patients hospitalized for at least 48 h from January 1, 2010 to December 31, 2015 in a 654-bed university teaching hospital in Paris, France. Monthly computed CUSUM were evaluated for the detection of out-of-control situations, defined as incidence rates of acquired AMR bacterial colonization exceeding acceptable thresholds at the hospital and ward levels (based on six selected wards) for AMR bacteria overall and Extended-spectrum beta-lactamases Enterobacteriaceae (ESBL-E) and Methicillin-resistant Staphylococcus aureus (MRSA), specifically...
March 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28299645/new-concepts-in-embolotherapy-of-hcc
#8
REVIEW
F Pesapane, N Nezami, F Patella, J F Geschwind
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths worldwide with rapidly growing incidence rates in the USA and Europe. Despite improving surveillance programs, most patients are diagnosed at intermediate to advanced stages and are no longer amenable to curative therapies, such as ablation, surgical resection and liver transplantation. For such patients, catheter-based image-guided embolotherapies such as transarterial chemoembolization (TACE) represent the standard of care and mainstay therapy, as recommended and endorsed by a variety of national guidelines and staging systems...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28298471/bk-polyomavirus-clinical-aspects-immune-regulation-and-emerging-therapies
#9
REVIEW
George R Ambalathingal, Ross S Francis, Mark J Smyth, Corey Smith, Rajiv Khanna
BK polyomavirus (BKV) causes frequent infections during childhood and establishes persistent infections within renal tubular cells and the uroepithelium, with minimal clinical implications. However, reactivation of BKV in immunocompromised individuals following renal or hematopoietic stem cell transplantation may cause serious complications, including BKV-associated nephropathy (BKVAN), ureteric stenosis, or hemorrhagic cystitis. Implementation of more potent immunosuppression and increased posttransplant surveillance has resulted in a higher incidence of BKVAN...
April 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28291496/public-health-surveillance-via-template-management-in-electronic-health-records-tri-service-workflow-s-rapid-response-to-an-infectious-disease-crisis
#10
Holly Berkley, Matthew Barnes, David Carnahan, Janet Hayhurst, Archie Bockhorst, James Neville
OBJECTIVE: To describe the use of template-based screening for risk of infectious disease exposure of patients presenting to primary care medical facilities during the 2014 West African Ebola virus outbreak. METHODS: The Military Health System implemented an Ebola risk-screening tool in primary care settings in order to create early notifications and early responses to potentially infected persons. Three time-sensitive, evidence-based screening questions were developed and posted to Tri-Service Workflow (TSWF) AHLTA templates in conjunction with appropriate training...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288568/deep-sequencing-of-hpv-e6-e7-genes-reveals-loss-of-genotypic-diversity-and-gain-of-clonal-dominance-in-high-grade-intraepithelial-lesions-of-the-cervix
#11
Jane Shen-Gunther, Yufeng Wang, Zhao Lai, Graham M Poage, Luis Perez, Tim H M Huang
BACKGROUND: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. HPV genotyping by dideoxy (Sanger) sequencing is currently the reference method of choice for clinical diagnostics. However, for samples with multiple HPV infections, genotype identification is singular and occasionally imprecise or indeterminable due to overlapping chromatograms. Our aim was to explore and compare HPV metagenomes in abnormal cervical cytology by deep sequencing for correlation with disease states...
March 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28280601/minimal-residual-disease-in-melanoma-circulating-melanoma-cells-and-predictive-role-of-mcam-muc18-melcam-cd146
#12
REVIEW
Maria Cristina Rapanotti, Elena Campione, Giulia Spallone, Augusto Orlandi, Sergio Bernardini, Luca Bianchi
Circulating tumour cells (CTCs), identified in numerous cancers including melanoma, are unquestionably considered valuable and useful as diagnostic and prognostic markers. They can be detected at all melanoma stages and may persist long after treatment. A crucial step in metastatic processes is the intravascular invasion of neoplastic cells as circulating melanoma cells (CMCs). Only a small percentage of these released cells are efficient and capable of colonizing with a strong metastatic potential. CMCs' ability to survive in circulation express a variety of genes with continuous changes of signal pathways and proteins to escape immune surveillance...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28276868/population-based-birth-weight-reference-percentiles-for-chinese-twins
#13
Li Dai, Changfei Deng, Yanhua Li, Ling Yi, Xiaohong Li, Yi Mu, Qi Li, Qiang Yao, Yanping Wang
BACKGROUND: Birth weight percentiles by gestational age are important for assessing prenatal growth and predicting postnatal outcomes of newborns. Several countries have developed nation-specific birth weight references for twins, but China still lacks such references. METHODS AND RESULTS: Birth weight data for twins born between October 2006 and September 2015 were abstracted from the China National Population-based Birth Defects Surveillance System. A total of 54,786 live twin births aged ≥28 weeks of gestation without birth defects were included in the analysis...
February 28, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28276586/the-eating-and-drinking-ability-classification-system-in-a-population-based-sample-of-preschool-children-with-cerebral-palsy
#14
Katherine A Benfer, Kelly A Weir, Kristie L Bell, Robert S Ware, Peter Sw Davies, Roslyn N Boyd
AIM: To determine (1) the reproducibility of the Eating and Drinking Ability Classification System (EDACS); (2) EDACS classification distribution in a population-based cohort with cerebral palsy (CP); and (3) the relationships between the EDACS and clinical mealtime assessment, other classifications, and health outcomes. METHOD: This was a cross-sectional population-based cohort study of 170 children with CP at 3 years to 5 years (mean 57.6mo, standard deviation [SD] 8...
March 9, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28273858/use-of-a-pan-genomic-dna-microarray-in-determination-of-the-phylogenetic-relatedness-among-cronobacter-spp-and-its-use-as-a-data-mining-tool-to-understand-cronobacter-biology
#15
REVIEW
Ben D Tall, Jayanthi Gangiredla, Christopher J Grim, Isha R Patel, Scott A Jackson, Mark K Mammel, Mahendra H Kothary, Venugopal Sathyamoorthy, Laurenda Carter, Séamus Fanning, Carol Iversen, Franco Pagotto, Roger Stephan, Angelika Lehner, Jeffery Farber, Qiong Q Yan, Gopal R Gopinath
Cronobacter (previously known as Enterobacter sakazakii) is a genus of Gram-negative, facultatively anaerobic, oxidase-negative, catalase-positive, rod-shaped bacteria of the family Enterobacteriaceae. These organisms cause a variety of illnesses such as meningitis, necrotizing enterocolitis, and septicemia in neonates and infants, and urinary tract, wound, abscesses or surgical site infections, septicemia, and pneumonia in adults. The total gene content of 379 strains of Cronobacter spp. and taxonomically-related isolates was determined using a recently reported DNA microarray...
March 4, 2017: Microarrays
https://www.readbyqxmd.com/read/28270152/a-systematic-review-on-malaria-sero-epidemiology-studies-in-the-brazilian-amazon-insights-into-immunological-markers-for-exposure-and-protection
#16
Pedro M Folegatti, André M Siqueira, Wuelton M Monteiro, Marcus Vinícius G Lacerda, Chris J Drakeley, Érika M Braga
BACKGROUND: Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and counting clinical cases, elimination will require the use of efficient tools and strategies for measuring transmission dynamics and detecting the infectious reservoir as the primary indicators of interest for surveillance and evaluation. Because acquisition and maintenance of anti-malarial antibodies depend on parasite exposure, seroprevalence rates could be used as a reliable tool for assessing malaria endemicity and an adjunct measure for monitoring transmission in a rapid and cost-effective manner...
March 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28264857/the-malaria-taqman-array-card-87-assays-for-plasmodium-falciparum-drug-resistance-speciation-and-genotyping-in-a-single-reaction
#17
Suporn Pholwat, Jie Liu, Suzanne Stroup, Shevin Jacob, Patrick Banura, Christopher Moore, Fang Huang, Miriam Laufer, Eric Houpt, Jennifer Guler
Antimalarial drug resistance exacerbates the global disease burden and complicates eradication efforts. To facilitate the surveillance of resistance markers in malaria-endemic countries, we developed a suite of TaqMan assays for known resistance markers and compartmentalized them into a single array card (TAC). We included 87 assays for species identification, the detection of Plasmodium falciparum mutations associated with chloroquine, atovaquone, pyrimethamine, sulfadoxine, and artemisinin resistance, and neutral single nucleotide polymorphism (SNP) genotyping...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28238953/cost-effectiveness-of-screening-patients-with-gastroesophageal-reflux-disease-for-barrett-s-esophagus-with-a-minimally-invasive-cell-sampling-device
#18
Curtis R Heberle, Amir-Houshang Omidvari, Ayman Ali, Sonja Kroep, Chung Yin Kong, John M Inadomi, Joel H Rubenstein, Angela C Tramontano, Emily C Dowling, William D Hazelton, E Georg Luebeck, Iris Lansdorp-Vogelaar, Chin Hur
BACKGROUND & AIMS: It is important to identify patients with Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with BE are usually identified by endoscopy, which is expensive. The cytosponge, which collects tissue from the esophagus non-invasively, could be a cost-effective tool for screening individuals with gastroesophageal reflux disease (GERD), who are at increased risk for BE. We developed a model to analyze the cost effectiveness of using cytosponge in first-line screening of patients with GERD for BE with endoscopic confirmation, compared to endoscopy screening only, METHODS: We incorporated data from a large clinical trial of cytosponge performance into 2 validated microsimulation models of EAC progression (the esophageal adenocarcinoma model from the Massachusetts General Hospital and the microsimulation screening analysis model from Erasmus University Medical Center)...
February 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28238506/rapid-diagnosis-of-gastrointestinal-tract-infections-due-to-parasites-viruses-and-bacteria
#19
Luz Balsalobre-Arenas, Teresa Alarcón-Cavero
Rapid diagnostic techniques are valuable tools in the diagnosis of gastrointestinal infections, especially for the detection of some microorganisms and in certain groups of patients. While antigen detection techniques are widely used in Clinical Microbiology laboratories, for the diagnosis of viruses, some parasites and some bacteria, molecular techniques are routinely used only for some pathogens (such as Clostridium difficile). However, molecular techniques are constantly evolving, and they allow a rapid diagnosis for an increasing number of pathogens, with high sensitivity and specificity...
February 23, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28231244/unexpectedly-high-leprosy-seroprevalence-detected-using-a-random-surveillance-strategy-in-midwestern-brazil-a-comparison-of-elisa-and-a-rapid-diagnostic-test
#20
Marco Andrey C Frade, Natália A de Paula, Ciro M Gomes, Sebastian Vernal, Fred Bernardes Filho, Helena B Lugão, Marilda M M de Abreu, Patrícia Botini, Malcolm S Duthie, John S Spencer, Rosa Castália F R Soares, Norma T Foss
BACKGROUND: Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to compare the performance of different serological tests. METHODS: A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test...
February 2017: PLoS Neglected Tropical Diseases
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