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https://www.readbyqxmd.com/read/29773435/epidemiology-of-antifungal-susceptibility-review-of-literature
#1
REVIEW
I Hadrich, A Ayadi
Fungal infections are a major cause of morbidity and mortality despite the latest developments of diagnostic tools and therapeutic options. Early initiation of the appropriate antifungal therapy has been demonstrated to have a direct impact on the patient's outcome. Antifungal susceptibility testing methods are available to detect antifungal resistance and to determine the best treatment for a specific fungus. American and European standards have been developed, as well as equivalent commercial systems, which are more appropriate for clinical laboratories...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29772103/how-can-we-expand-active-surveillance-criteria-in-patients-with-low-and-intermediate-risk-prostate-cancer-without-increasing-the-risk-of-misclassification-development-of-a-novel-risk-calculator
#2
Giorgio Gandaglia, Roderick C N van den Bergh, Derya Tilki, Nicola Fossati, Piet Ost, Christian I Surcel, Prasanna Sooriakumaran, Igor Tsaur, Massimo Valerio, Alexander Kretschmer, Emanuele Zaffuto, Laurent Salomon, Francesco Montorsi, Markus Graefen, Henk van der Poel, Alexandre de la Taille, Alberto Briganti, Guillaume Ploussard
OBJECTIVE: To develop a novel tool to increase the number of prostate cancer (PCa) patients eligible for active surveillance (AS) without increasing the risk of unfavourable pathologic features (i.e., misclassification) at radical prostatectomy (RP). MATERIALS AND METHODS: Overall, 16,049 patients with low- or intermediate risk PCa treated with RP were identified. Misclassification was defined as non-organ confined or grade group ≥3 disease at RP. The coefficients of a logistic regression model predicting misclassification were used to develop a risk score...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29768703/a-statistical-tool-for-risk-assessment-as-function-of-number-of-retrieved-lymph-nodes-from-rectal-cancer-patients
#3
Zhenyu Wu, Guoyou Qin, Naiqing Zhao, Huixun Jia, Xueying Zheng
PURPOSE: Although a minimum of 12 lymph nodes (LNs) has been recommended for colorectal cancer, there remains considerable debates for rectal cancer patients. Inadequacy of examined LNs would lead to under-staging, and inappropriate treatment as a consequence. We describe statistical tool that allows an estimate the probability of false-negative nodes. METHODS: A total of 26,778 adenocarcinoma rectum cancer patients with tumour stage (T stage) 1-3, diagnosed between 2004 and 2013, who did not receive neoadjuvant therapies and had at least one histologically assessed LN, were extracted from the Surveillance, Epidemiology and End Results (SEER) database...
May 16, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29763640/development-of-fluorescent-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp-using-quenching-probes-for-the-detection-of-the-middle-east-respiratory-syndrome-coronavirus
#4
Kazuya Shirato, Shohei Semba, Sherif A El-Kafrawy, Ahmed M Hassan, Ahmed M Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar
Clinical detection of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) in patients is achieved using genetic diagnostic methods, such as real-time RT-PCR assay. Previously, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of MERS-CoV [Virol J. 2014. 11:139]. Generally, amplification of RT-LAMP is monitored by the turbidity induced by precipitation of magnesium pyrophosphate with newly synthesized DNA. However, this mechanism cannot completely exclude the possibility of unexpected reactions...
May 12, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29762660/quality-indicators-and-their-regular-use-in-clinical-practice-results-from-a-survey-among-users-of-two-cardiovascular-national-registries-in-sweden
#5
Beatrix Algurén, Boel Andersson-Gäre, Johan Thor, Ann-Christine Andersson
Objective: To examine the regular use of quality indicators from Swedish cardiovascular National Quality Registries (NQRs) by clinical staff; particularly differences in use between the two NQRs and between nurses and physicians. Design: Cross-sectional online survey study. Setting: Two Swedish cardiovascular NQRs: (a) Swedish Heart Failure Registry and (b) Swedeheart. Participants: Clinicians (n =185; 70% nurses, 26% physicians) via the NQRs' email networks...
May 14, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29761281/characteristics-quality-and-contribution-to-signal-detection-of-spontaneous-reports-of-adverse-drug-reactions-via-the-web-radr-mobile-application-a-descriptive-cross-sectional-study
#6
Ingrid Oosterhuis, Henric Taavola, Philip M Tregunno, Petar Mas, Sara Gama, Victoria Newbould, Ola Caster, Linda Härmark
INTRODUCTION: Spontaneous reporting of suspected adverse drug reactions is key for efficient post-marketing safety surveillance. To increase usability and accessibility of reporting tools, the Web-Recognising Adverse Drug Reactions (WEB-RADR) consortium developed a smartphone application (app) based on a simplified reporting form. OBJECTIVE: The objective of this study was to evaluate the characteristics, quality and contribution to signals of reports submitted via the WEB-RADR app...
May 14, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29761074/the-clinical-utility-of-cell-free-dna-measurement-in-differentiated-thyroid-cancer-a-systematic-review
#7
Jonathan M Fussey, Jennifer L Bryant, Nikolaos Batis, Rachael J Spruce, Andrew Hartley, James S Good, Christopher J McCabe, Kristien Boelaert, Neil Sharma, Hisham Mehanna
Background: Cell-free DNA (cfDNA) can be detected in the circulation of healthy individuals, but is found in higher concentrations in cancer patients. Furthermore, mutations in tumor cells can be identified in circulating DNA fragments. This has been the subject of significant interest in the field of cancer research, but little has been published in thyroid cancer. Objectives: To assess all available evidence on the use of circulating cfDNA in the diagnosis, management and surveillance of patients with differentiated thyroid cancer, and collate it into a systematic review to guide future research...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29753917/assessment-of-intrafamilial-clinical-variability-of-poikiloderma-with-neutropenia-by-a-10-year-follow-up-of-three-affected-siblings
#8
Daniela Concolino, Simona Sestito, Francesca Falvo, Giusy Romano, Miriam Ceravolo, Elisa Anastasio, Licia Pensabene, Elisa A Colombo, Lidia Larizza
Clericuzio-type poikiloderma with neutropenia is a well-defined nosological entity, but despite a remarkable number of clinical reports, no long term follow-up data has been presented to date regarding patients with this rare condition. Here we describe the results of clinical follow-up of three siblings, one male (Patient 1) and two females (Patients 2 and 3), subsequent to their first clinical and then molecular diagnosis of Clericuzio-type poikiloderma with neutropenia syndrome due to mutation of USB1gene...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29751767/development-of-gold-nanoparticles-biosensor-for-ultrasensitive-diagnosis-of-foot-and-mouth-disease-virus
#9
Mervat E Hamdy, Michele Del Carlo, Hussein A Hussein, Taher A Salah, Ayman H El-Deeb, Mohamed M Emara, Guilia Pezzoni, Dario Compagnone
BACKGROUND: Nano-PCR is a recent tool that is used in viral diseases diagnosis. The technique depends on the fundamental effects of gold nanoparticles (AuNPs) and is considered a very effective and sensitive tool in the diagnosis of different diseases including viral diseases. Although several techniques are currently available to diagnose foot and mouth disease virus (FMDV), a highly sensitive, highly specific technique is needed for specific diagnosis of the disease. In the present work, a novel AuNPs biosensor has been designed using thiol-linked oligonucleotides that recognize the conserved 3D gene of FMDV...
May 11, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29750288/recognizing-and-managing-children-with-a-pediatric-cancer-predisposition-syndrome-a-guide-for-the-pediatrician
#10
Stephanie A Coury, Katherine A Schneider, Jaclyn Schienda, Wen-Hann Tan
It is estimated that at least 8% to 10% of children diagnosed with cancer have an inherited cancer predisposition syndrome. Pediatricians may be called upon to (1) identify children with symptoms suggestive of cancer that require further diagnostic testing, (2) identify children who should be referred to cancer genetics based on their personal and family histories, and (3) provide primary care to children who have an inherited cancer syndrome. This review article provides a list of clinical warning signs suggestive of childhood malignancy, discusses the personal and family history "red flags" suggestive of hereditary cancer, offers checklists to help identify patients who are candidates for cancer genetics evaluation, and describes features of the major pediatric cancer syndromes involving solid tumors and surveillance guidelines...
May 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29745965/stroke-distribution-patterns-and-characteristics-in-kenya-s-leading-public-health-tertiary-institutions-kenyatta-national-hospital-and-moi-teaching-and-referral-hospital
#11
Lydia Kaduka, Anne Korir, Chrispine Owuor Oduor, Judith Kwasa, Jane Mbui, Sylvanos Wabwire, Robai Gakunga, Nathan Okerosi, Yvonne Opanga, Isaac Kisiang'ani, Mercy Rotich Chepkurui, Erastus Muniu, Scot C Remick
BACKGROUND: Cardiovascular diseases are the second leading cause of morbidity and mortality in Kenya. However, there is limited clinic-epidemiological data on stroke to inform decision making. This study sought to establish stroke distribution patterns and characteristics in patients seeking care at Kenyatta National Hospital (KNH) and Moi Teaching and Referral Hospital (MTRH), with the ultimate aim of establishing the first national stroke registry in Kenya. METHODS: This was a prospective multicentre cohort study among stroke patients...
March 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29744602/current-clinical-topics-of-lynch-syndrome
#12
REVIEW
Kohji Tanakaya
Lynch syndrome (LS) is one of the most common genetic cancer syndromes, occurring at a rate of 1 per 250-1000 in the general population. This autosomal dominant disease is caused by a germline variant in one of the four mismatch repair genes, MSH2, MLH1, MSH6, PMS2, or the EPCAM gene. LS develops at early ages in colorectal cancer (CRC), endometrial cancer, and various other associated tumors. Accurate diagnosis of LS and utilization of various risk-reduction strategies such as surveillance, prophylactic surgery, and chemoprevention could improve clinical outcomes...
May 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29743119/profiling-microbial-strains-in-urban-environments-using-metagenomic-sequencing-data
#13
Moreno Zolfo, Francesco Asnicar, Paolo Manghi, Edoardo Pasolli, Adrian Tett, Nicola Segata
BACKGROUND: The microbial communities populating human and natural environments have been extensively characterized with shotgun metagenomics, which provides an in-depth representation of the microbial diversity within a sample. Microbes thriving in urban environments may be crucially important for human health, but have received less attention than those of other environments. Ongoing efforts started to target urban microbiomes at a large scale, but the most recent computational methods to profile these metagenomes have never been applied in this context...
May 9, 2018: Biology Direct
https://www.readbyqxmd.com/read/29740407/overview-of-virus-metagenomic-classification-methods-and-their-biological-applications
#14
REVIEW
Sam Nooij, Dennis Schmitz, Harry Vennema, Annelies Kroneman, Marion P G Koopmans
Metagenomics poses opportunities for clinical and public health virology applications by offering a way to assess complete taxonomic composition of a clinical sample in an unbiased way. However, the techniques required are complicated and analysis standards have yet to develop. This, together with the wealth of different tools and workflows that have been proposed, poses a barrier for new users. We evaluated 49 published computational classification workflows for virus metagenomics in a literature review. To this end, we described the methods of existing workflows by breaking them up into five general steps and assessed their ease-of-use and validation experiments...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29730017/positron-emission-tomography-computed-tomography-with-89-zr-girentuximab-can-aid-in-diagnostic-dilemmas-of-clear-cell-renal-cell-carcinoma-suspicion
#15
Marlène C H Hekman, Mark Rijpkema, Erik H Aarntzen, Sasja F Mulder, Johan F Langenhuijsen, Egbert Oosterwijk, Otto C Boerman, Wim J G Oyen, Peter F A Mulders
Based on the high expression of carbonic anhydrase IX (CAIX) in 95% of clear cell renal cell carcinoma (ccRCC), the anti-CAIX monoclonal antibody girentuximab can be used for the detection of ccRCC. This clinical study explores the value of 89 Zr-labeled girentuximab positron emission tomography/computed tomography (PET/CT) imaging in diagnostic challenges regarding ccRCC. PET/CT imaging was performed 4 or 5 d after injection of 89 Zr-girentuximab in patients with a primary renal mass (n=16) or a history of ccRCC (n=14)...
May 2, 2018: European Urology
https://www.readbyqxmd.com/read/29728348/the-acceptability-and-feasibility-of-implementing-a-bio-behavioral-enhanced-surveillance-tool-for-sexually-transmitted-infections-in-england-mixed-methods-study
#16
Sonali Wayal, David Reid, Paula B Blomquist, Peter Weatherburn, Catherine H Mercer, Gwenda Hughes
BACKGROUND: Sexually transmitted infection (STI) surveillance is vital for tracking the scale and pattern of epidemics; however, it often lacks data on the underlying drivers of STIs. OBJECTIVE: This study aimed to assess the acceptability and feasibility of implementing a bio-behavioral enhanced surveillance tool, comprising a self-administered Web-based survey among sexual health clinic attendees, as well as linking this to their electronic health records (EHR) held in England's national STI surveillance system...
May 4, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29724223/estimating-the-incidence-of-enteric-fever-in-children-in-india-a-multi-site-active-fever-surveillance-of-pediatric-cohorts
#17
Jacob John, Ashish Bavdekar, Temsunaro Rongsen-Chandola, Shanta Dutta, Gagandeep Kang
BACKGROUND: Salmonella Typhi is responsible for about 20 million episodes of illness and over 140,000 deaths annually globally. South Asia has the highest documented burden of typhoid and is home to the multi-drug resistant H58 strain that makes treatment more challenging. The WHO recommends the use of Typhoid Conjugate Vaccines in typhoid endemic countries. Decisions on the preferred immunization strategy should be based on an analysis of disease burden, availability, affordability, and operational feasibility...
May 3, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29716911/early-warning-score-communication-bundle-a-pilot-study
#18
EDITORIAL
Cheryl Gagne, Susan Fetzer
BACKGROUND: Unplanned admissions of patients to intensive care units from medical-surgical units often result from failure to recognize clinical deterioration. The early warning score is a clinical decision support tool for nurse surveillance but must be communicated to nurses and implemented appropriately. A communication process including collaboration with experienced intensive care unit nurses may reduce unplanned transfers. OBJECTIVE: To determine the impact of an early warning score communication bundle on medical-surgical transfers to the intensive care unit, rapid response team calls, and morbidity of patients upon intensive care unit transfer...
May 2018: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29713755/prognostic-factors-and-prognostic-models-for-renal-cell-carcinoma-a-literature-review
#19
REVIEW
Tobias Klatte, Sabrina H Rossi, Grant D Stewart
PURPOSE: Following curative treatment for localised renal cell carcinoma (RCC), up to 30% of patients develop tumour recurrence. Prognostic scores are essential to guide individualised surveillance protocols, patient counselling and potentially in the future to guide adjuvant therapy. In metastatic RCC, prognostic scores are routinely used for treatment selection in clinical practice as well as in all major trials. METHODS: We performed a literature review on the current evidence based on prognostic factors and models for localised and metastatic RCC...
April 30, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29712429/in-silico-pharmacoepidemiologic-evaluation-of-drug-induced-cardiovascular-complications-using-combined-classifiers
#20
Chuipu Cai, Jiansong Fang, Pengfei Guo, Qi Wang, Huixiao Hong, Javid Moslehi, Feixiong Cheng
Drug-induced cardiovascular complications are the most common adverse drug events and account for the withdrawal or severe restrictions on use of multitudinous post-marketed drugs. In this study, we developed new in silico models for systematic identification of drug-induced cardiovascular complications in drug discovery and post-marketing surveillance. Specifically,we collected drug-induced cardiovascular complications covering five most common types of cardiovascular outcomes (hypertension, heart block, arrhythmia, cardiac failure, and myocardial infarction) from four publicly available data resources: Comparative Toxicogenomics Database, SIDER, Offsides, and MetaADEDB...
April 30, 2018: Journal of Chemical Information and Modeling
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