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https://www.readbyqxmd.com/read/28936633/evaluation-of-an-online-family-history-tool-for-identifying-hereditary-and-familial-colorectal-cancer
#1
F G J Kallenberg, C M Aalfs, F O The, C A Wientjes, A C Depla, M W Mundt, P M M Bossuyt, E Dekker
Identifying a hereditary colorectal cancer (CRC) syndrome or familial CRC (FCC) in a CRC patient may enable the patient and relatives to enroll in surveillance protocols. As these individuals are insufficiently recognized, we evaluated an online family history tool, consisting of a patient-administered family history questionnaire and an automated genetic referral recommendation, to facilitate the identification of patients with hereditary CRC or FCC. Between 2015 and 2016, all newly diagnosed CRC patients in five Dutch outpatient clinics, were included in a trial with a stepped-wedge design, when first visiting the clinic...
September 21, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28934984/a-simple-and-rapid-identification-method-for-newly-emerged-porcine-deltacoronavirus-with-loop-mediated-isothermal-amplification
#2
Fanfan Zhang, Yu Ye, Deping Song, Nannan Guo, Qi Peng, Anqi Li, Xingrong Zhou, Yanjun Chen, Min Zhang, Dongyan Huang, Yuxin Tang
BACKGROUND: Porcine Deltacoronavirus (PDCoV) is a newly emerged enteropathogenic coronavirus that causes diarrhea and mortality in neonatal piglets. PDCoV has spread to many countries around the world, leading to significant economic losses in the pork industry. Therefore, a rapid and sensitive method for detection of PDCoV in clinical samples is urgently needed. RESULTS: In this study, we developed a single-tube one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay specific for nucleocapsid gene to diagnose and monitor PDCoV infections...
September 21, 2017: Biological Research
https://www.readbyqxmd.com/read/28929961/-national-antimicrobial-resistance-surveillance-system-namrss-external-quality-assessment-studies-2011-2016
#3
Serap Süzük Yıldız, Hüsniye Şimşek, Nilay Çöplü, Zeynep Gülay
Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Surveillance System (NARSS) has been established within the Public Health Institute of Turkey (PHIT) in our country since 2011. In the scope of this surveillance, NARSS EQA program has been implemented in a cycle per year and four isolates were sent to participants per cycle every year since 2011...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28922838/comparative-genomics-of-a-drug-resistant-pseudomonas-aeruginosa-panel-and-the-challenges-of-antimicrobial-resistance-prediction-from-genomes
#4
J Jeukens, I Kukavica-Ibrulj, J G Emond-Rheault, L Freschi, R C Levesque
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The accessibility of microbial whole-genome sequencing offers an invaluable opportunity for resistance surveillance via the resistome, i.e. the genes and mutations underlying AMR. Unfortunately, AMR prediction from genomic data remains extremely challenging, especially for species with a large pan-genome. One such organism, for which multidrug-resistant (MDR) isolates are frequently encountered in the clinic, is Pseudomonas aeruginosa...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28921446/can-a-novel-icu-data-display-positively-affect-patient-outcomes-and-save-lives
#5
Natalia Olchanski, Mikhail A Dziadzko, Ing C Tiong, Craig E Daniels, Steve G Peters, John C O'Horo, Michelle N Gong
The aim of this study was to quantify the impact of ProCCESs AWARE, Ambient Clinical Analytics, Rochester, MN, a novel acute care electronic medical record interface, on a range of care process and patient health outcome metrics in intensive care units (ICUs). ProCCESs AWARE is a novel acute care EMR interface that contains built-in tools for error prevention, practice surveillance, decision support and reporting. We compared outcomes before and after AWARE implementation using a prospective cohort and a historical control...
September 18, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28915243/rapid-actionable-diagnosis-of-urban-epidemic-leptospirosis-using-a-pathogenic-leptospira-lipl32-based-real-time-pcr-assay
#6
Irina N Riediger, Robyn A Stoddard, Guilherme S Ribeiro, Sueli M Nakatani, Suzana D R Moreira, Irene Skraba, Alexander W Biondo, Mitermayer G Reis, Alex R Hoffmaster, Joseph M Vinetz, Albert I Ko, Elsio A Wunder
BACKGROUND: With a conservatively estimated 1 million cases of leptospirosis worldwide and a 5-10% fatality rate, the rapid diagnosis of leptospirosis leading to effective clinical and public health decision making is of high importance, and yet remains a challenge. METHODOLOGY: Based on parallel, population-based studies in two leptospirosis-endemic regions in Brazil, a real-time PCR assay which detects lipL32, a gene specifically present in pathogenic Leptospira, was assessed for the diagnostic effectiveness and accuracy...
September 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28903730/routine-monitoring-and-assessment-of-adults-living-with-hiv-results-of-the-british-hiv-association-bhiva-national-audit-2015
#7
A Molloy, H Curtis, F Burns, A Freedman
BACKGROUND: The clinical care of people living with HIV changed fundamentally as a result of the development of effective antiretroviral therapy (ART). HIV infection is now a long-term treatable condition. We report a national audit to assess adherence to British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals. METHODS: All UK sites known as providers of adult HIV outpatient services were invited to complete a case-note review and a brief survey of local clinic practices...
September 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28902286/specific-antigen-serologic-tests-in-leprosy-implications-for-epidemiological-surveillance-of-leprosy-cases-and-household-contacts
#8
Ana Paula Mendes Carvalho, Angélica da Conceição Oliveira Coelho, Rodrigo Correa-Oliveira, Francisco Carlos Félix Lana
BACKGROUND: There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE: The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (NDOLID)...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28899995/hiv-seroconversion-among-baltimore-city-residents-tested-at-a-mobile-van-programme
#9
Sarah Puryear, Phyllis Burnett, Kathleen R Page, Ravikiran Muvva, Patrick Chaulk, Khalil G Ghanem, Anne Monroe
BACKGROUND: Many individuals with HIV in the USA are unaware of their diagnosis, and therefore cannot be engaged in treatment services, have worse clinical outcomes and are more likely to transmit HIV to others. Mobile van testing may increase HIV testing and diagnosis. Our objective was to characterise risk factors for HIV seroconversion among individuals using mobile van testing. METHODS: A case cohort study (n=543) was conducted within an HIV surveillance dataset of mobile van testing users with at least two HIV tests between September 2004 and August 2009 in Baltimore, Maryland...
September 12, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28898981/performance-of-the-cobas-mrsa-sa-test-for-simultaneous-detection-of-methicillin-susceptible-and-methicillin-resistant-staphylococcus-aureus-from-nasal-swabs
#10
Lance R Peterson, Christopher W Woods, Thomas E Davis, Zi-Xuam Wang, Stephen A Young, John C Osiecki, Michael A Lewinski, Oliver Liesenfeld
Objectives: Health care-associated methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (SA) infections are continuing problems. Rapidly determining the MRSA colonization status of a patient facilitates practice to reduce spread of MRSA clinical disease. Sensitive detection of all SA prior to surgery, followed by decolonization, can significantly reduce postoperative infection from this pathogen. Our goal was to validate a new automated assay for this testing. Methods: We compared performance of the cobas MRSA/SA Test on the cobas 4800 System to direct and enriched chromogenic culture using nasal swabs collected from patients at six United States sites...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28893637/advances-in-the-diagnosis-of-bovine-besnoitiosis-current-options-and-applications-for-control
#11
REVIEW
Daniel Gutiérrez-Expósito, Ignacio Ferre, Luis M Ortega-Mora, Gema Álvarez-García
Bovine besnoitiosis, which is caused by the tissue cyst-forming intracellular parasite Besnoitia besnoiti, is a chronic and debilitating disease that is responsible for severe economic losses in the cattle raised under extensive husbandry systems. The absence of vaccines, treatments or a health scheme at local, national and international levels has led to a rapid spread of bovine besnoitiosis from western Europe towards eastern countries and northwards. Moreover, this parasitic disease is widely present in many sub-Saharan countries...
September 9, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#12
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28893258/epidemiological-and-clinical-assessment-of-a-shared-territorial-malaria-guideline-in-the-10%C3%A2-years-of-its-implementation-barcelona-north-metropolitan-area-catalonia-spain-2007-2016
#13
Josep M Mòdol, Sílvia Roure, Àlex Smithson, Gema Fernández-Rivas, Anna Esquerrà, Neus Robert, María Méndez, Javier Ramos, Anna Carreres, Lluís Valerio
BACKGROUND: Malaria remains a major source of morbi-mortality among travellers. In 2007, a consensual multicenter Primary Care-Hospital shared guideline on travel-prior chemoprophylaxis, diagnosis and clinical management of imported malaria was set up in the Barcelona North Metropolitan area. The aim of the study is to assess the evolution of malaria cases in the area as well as its clinical management over the 10 years of its implementation. RESULTS: A total of 190 malaria cases, all them imported, have been recorded...
September 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28889391/urinary-protein-markers-for-the-detection-and-prognostication-of-urothelial-carcinoma
#14
Tibor Szarvas, Péter Nyirády, Takashi Kobayashi, Osamu Ogawa, Charles J Rosser, Hideki Furuya
Bladder cancer diagnosis and surveillance is mainly based on cystoscopy and urine cytology. However, both methods have significant limitations; urine cytology has a low sensitivity for low-grade tumors, while cystoscopy is uncomfortable for the patients. Therefore, in the last decade urine analysis was the subject of intensive research resulting in the identification of many potential biomarkers for the detection, surveillance, or prognostic stratification of bladder cancer. Current trends move toward the development of multiparametric models to improve the diagnostic accuracy compared with single molecular markers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28887345/design-and-implementation-of-population-based-specialty-care-programs
#15
Sheila R Botts, Michael T Gee, Christopher C Chang, Iris Young, Logan Saito, Alfred E Lyman
PURPOSE: The development, implementation, and scaling of 3 population-based specialty care programs in a large integrated healthcare system are reviewed, and the role of clinical pharmacy services in ensuring safe, effective, and affordable care is highlighted. SUMMARY: The Kaiser Permanente (KP) integrated healthcare delivery model allows for rapid development and expansion of innovative population management programs involving pharmacy services. Clinical pharmacists have assumed integral roles in improving the safety and effectiveness of high-complexity, high-cost care for specialty populations...
September 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28883912/infection-control-at-an-urban-hospital-in-manila-philippines-a-systems-engineering-assessment-of-barriers-and-facilitators
#16
Kaitlin F Mitchell, Anna K Barker, Cybele L Abad, Nasia Safdar
BACKGROUND: Healthcare facilities in low- and middle-income countries, including the Philippines, face substantial challenges in achieving effective infection control. Early stages of interventions should include efforts to understand perceptions held by healthcare workers who participate in infection control programs. METHODS: We performed a qualitative study to examine facilitators and barriers to infection control at an 800-bed, private, tertiary hospital in Manila, Philippines...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28881475/the-cancer-of-the-bladder-risk-assessment-cobra-score-estimating-mortality-after-radical-cystectomy
#17
Christopher J Welty, Thomas H Sanford, Jonathan L Wright, Peter R Carroll, Matthew R Cooperberg, Maxwell V Meng, Sima P Porten
BACKGROUND: Risk stratification of patients with urothelial carcinoma of the bladder (UCB) after cystectomy has important clinical and research implications. The authors assessed the relative effect of tumor stage and lymph node status on cancer-specific survival (CSS) after cystectomy and developed a simplified risk-assessment tool. METHODS: In total, 14,828 patients who underwent cystectomy with lymph node dissection for UCB were identified from the Surveillance, Epidemiology, and End Results database (1988-2011)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28880857/brca-genetic-testing-and-receipt-of-preventive-interventions-among-women-aged-18-64-years-with-employer-sponsored-health-insurance-in-nonmetropolitan-and-metropolitan-areas-united-states-2009-2014
#18
Katherine Kolor, Zhuo Chen, Scott D Grosse, Juan L Rodriguez, Ridgely Fisk Green, W David Dotson, M Scott Bowen, Julie A Lynch, Muin J Khoury
PROBLEM/CONDITION: Genetic testing for breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) gene mutations can identify women at increased risk for breast and ovarian cancer. These testing results can be used to select preventive interventions and guide treatment. Differences between nonmetropolitan and metropolitan populations in rates of BRCA testing and receipt of preventive interventions after testing have not previously been examined. PERIOD COVERED: 2009-2014...
September 8, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28866371/no-longer-any-role-for-routine-follow-up-chest-x-rays-in-men-with-stage-i-germ-cell-cancer
#19
H De La Pena, A Sharma, C Glicksman, J Joseph, M Subesinghe, Z Traill, C Verrill, M Sullivan, J Redgwell, E Bataillard, E Pintus, N Dallas, A Gogbashian, M Tuthill, A Protheroe, M Hall
Following radical orchidectomy for testicular cancer, most patients undergo protocolled surveillance to detect tumour recurrences rather than receive adjuvant chemotherapy. Current United Kingdom national and most international guidelines recommend that patients require a chest x-ray (CXR) and serum tumour markers at each follow-up visit as well as regular CT scans; there is however, variation among cancer centres with follow-up protocols. Seminomas often do not cause tumour marker elevation; therefore, CT scans are the main diagnostic tool for detecting relapse...
August 31, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28859442/emerging-multidrug-resistance-in-community-associated-staphylococcus-aureus-involved-in-skin-and-soft-tissue-infections-and-nasal-colonization
#20
Grace C Lee, Steven D Dallas, Yufeng Wang, Randall J Olsen, Kenneth A Lawson, James Wilson, Christopher R Frei
Background: Staphylococcus aureus is a major pathogen causing significant morbidity and mortality worldwide. The emergence of MDR S. aureus strains in the community setting has major implications in disease management. However, data regarding the occurrence and patterns of MDR community-associated S. aureus sub-clones is limited. Objectives: To use whole-genome sequences to describe the diversity and distribution of resistance mechanisms among community-associated S...
September 1, 2017: Journal of Antimicrobial Chemotherapy
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