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Spinal cord injury trials

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https://www.readbyqxmd.com/read/29164021/efficacy-safety-and-timing-of-anticoagulant-thromboprophylaxis-for-the-prevention-of-venous-thromboembolism-in-patients-with-acute-spinal-cord-injury-a-systematic-review
#1
REVIEW
Paul M Arnold, James S Harrop, Geno Merli, Lindsay G Tetreault, Brian K Kwon, Steve Casha, Katherine Palmieri, Jefferson R Wilson, Michael G Fehlings, Haley K Holmer, Daniel C Norvell
Study Design: Systematic review. Objectives: The objective of this study was to answer 5 key questions: What is the comparative effectiveness and safety of (1a) anticoagulant thromboprophylaxis compared to no prophylaxis, placebo, or another anticoagulant strategy for preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) after acute spinal cord injury (SCI)? (1b) Mechanical prophylaxis strategies alone or in combination with other strategies for preventing DVT and PE after acute SCI? (1c) Prophylactic inferior vena cava filter insertion alone or in combination with other strategies for preventing DVT and PE after acute SCI? (2) What is the optimal timing to initiate and/or discontinue anticoagulant, mechanical, and/or prophylactic inferior vena cava filter following acute SCI? (3) What is the cost-effectiveness of these treatment options? Methods: A systematic literature search was conducted to identify studies published through February 28, 2015...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29161465/neuromuscular-electrical-stimulation-for-the-prevention-of-venous-thromboembolism
#2
REVIEW
Shahab Hajibandeh, Shahin Hajibandeh, George A Antoniou, James Rh Scurr, Francesco Torella
BACKGROUND: Venous thromboembolism (VTE) is a serious but preventable cause of morbidity and mortality. Neuromuscular electrical stimulation systems (NMES) for the prevention of VTE may be beneficial for patients in whom pharmacological or standard mechanical prophylaxis methods are contraindicated or are regarded as unsafe or impractical. Although findings of experimental studies suggest that NMES reduce venous stasis, the clinical utility and effectiveness of NMES in VTE prevention remain controversial...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29148128/step-ergometer-training-augmented-with-functional-electrical-stimulation-in-individuals-with-chronic-spinal-cord-injury-a-feasibility-study
#3
Candy Tefertiller, Don Gerber
Spinal cord injury (SCI) often results in loss of upright mobility and independence subsequently challenging rehabilitation practitioners for meaningful intervention strategies. The objective of this study was to evaluate the feasibility and potential impact on walking function of the stimulation and ergometer training protocol (STEP) in chronic SCI. Fourteen individuals with a chronic motor incomplete SCI (>1-year post injury) were enrolled in the study. The intervention consisted of a 12-week walking training program delivered three times per week from 20 up to 45 min in combination with 10 channels of FES on a step ergometer...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29131367/influence-of-the-neural-microenvironment-on-prostate-cancer
#4
Christian Coarfa, Diego Florentin, NagiReddy Putluri, Yi Ding, Jason Au, Dandan He, Ahmed Ragheb, Anna Frolov, George Michailidis, MinJae Lee, Dov Kadmon, Brian Miles, Christopher Smith, Michael Ittmann, David Rowley, Arun Sreekumar, Chad J Creighton, Gustavo Ayala
BACKGROUND: Nerves are key factors in prostate cancer (PCa), but the functional role of innervation in prostate cancer is poorly understood. PCa induced neurogenesis and perineural invasion (PNI), are associated with aggressive disease. METHOD: We denervated rodent prostates chemically and physically, before orthotopically implanting cancer cells. We also performed a human neoadjuvant clinical trial using botulinum toxin type A (Botox) and saline in the same patient, before prostatectomy...
November 13, 2017: Prostate
https://www.readbyqxmd.com/read/29125882/mir-137-inhibited-inflammatory-response-and-apoptosis-after-spinal-cord-injury-via-targeting-of-mk2
#5
Lin Gao, Chenfei Dai, Zhiping Feng, Lixin Zhang, Zhiqiang Zhang
Spinal cord injuries are common and troublesome disorder, which is mediated by various signal pathways and mechanisms. MK2 is also involved in numerous inflammatory diseases including spinal cord injury. The role of microRNA-137 (miR-137) and its detailed working mechanism in spinal cord injuries remain unclear. In the present study, we found that an elevated MK2 but a decreased miR-137 were expressed in serum specimens of patients with spinal cord injury and in hydrogen peroxide treated C8-D1A and C8-B4 cells...
November 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29116244/delivery-of-neostigmine-and-glycopyrrolate-by-iontophoresis-a-nonrandomized-study-in-individuals-with-spinal-cord-injury
#6
Mark A Korsten, Brian L Lyons, Miroslav Radulovic, Tradd M Cummings, Gautam Sikka, Kamaldeep Singh, Anton Sabiev, Ann M Spungen, William A Bauman
STUDY DESIGN: Phase I Clinical Trial. OBJECTIVES: In this proof-of-principle study, the effectiveness and safety of transdermal administration of neostigmine/glycopyrrolate to elicit a bowel movement was compared to intravenous administration in patients with spinal cord injury. SETTING: James J. Peters Veterans Affairs Medical Center (Bronx, NY). METHODS: Individuals were screened for responsiveness (Physical Response) to intravenous neostigmine (0...
November 8, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29114283/a-method-for-reconstruction-of-severely-damaged-spinal-cord-using-autologous-hematopoietic-stem-cells-and-platelet-rich-protein-as-a-biological-scaffold
#7
Ahmed Sabry Ammar, Yasser Osman, Ahmed Taher Hendam, Mohammed Ahmed Hasen, Fatma Abdullah Al Rubaish, Danya Yaagoub Al Nujaidi, Faisal Mishal Al Abbas
Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add our experience in our center of a surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein (PRP) with fibrin coated as a biological scaffold. Materials and Methods: Four cases of severely damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using SCs and platelet-rich protein (PRP) with fibrin coated harvested from the peripheral circulation of the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29111852/emg-triggered-stimulation-post-spinal-cord-injury-a-case-report
#8
Maryam Zoghi, Mary P Galea
BACKGROUND: Mechanical injury in patients with spinal cord injury (SCI) rarely transects the cord completely, even when the injury is classified as complete. These patients can show sub-clinical evidence of spared motor connections, which might be amenable to targeted rehabilitation. Neurophysiological evaluations can complement the clinical evaluation by providing objective data about conduction across the SCI site. CASE DESCRIPTION: A twenty-four year old patient with SCI was admitted to a rehabilitation centre 49 days post traumatic SCI...
November 7, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29110687/effects-of-high-frequency-transcranial-magnetic-stimulation-on-functional-performance-in-individuals-with-incomplete-spinal-cord-injury-study-protocol-for-a-randomized-controlled-trial
#9
Amanda Vitória Lacerda de Araújo, Valéria Ribeiro Nogueira Barbosa, Gilma Serra Galdino, Felipe Fregni, Thais Massetti, Sara Lynn Fontes, Danilo de Oliveira Silva, Talita Dias da Silva, Carlos Bandeira de Mello Monteiro, James Tonks, Fernando Henrique Magalhães
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been investigated as a new tool in neurological rehabilitation of individuals with spinal cord injury (SCI). However, due to the inconsistent results regarding the effects of rTMS in people with SCI, a randomized controlled double-blind crossover trial is needed to clarify the clinical utility and to assess the effect size of rTMS intervention in this population. Therefore, this paper describes a study protocol designed to investigate whether the use of rTMS can improve the motor and sensory function, as well as reduce spasticity in patients with incomplete SCI...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29099681/beyond-the-laboratory-into-the-clinic-what-dogs-with-disk-disease-have-taught-us-about-photobiomodulation-for-spinal-cord-injury
#10
Narda G Robinson
BACKGROUND: For spinal-cord-injured (SCI) patients, integrative medicine approaches such as photomedicine and acupuncture can renew hope and offer previously unrecognized ways to help regain function and improve quality of life. OBJECTIVE: By understanding the mechanisms of action that these two modalities share, practitioners can better target specific attributes of spinal cord pathophysiology that are limiting recovery. Naturally occurring intervertebral disk disease (IVDD) in dogs affords unparalleled translational opportunities to develop treatment strategies involving photobiomodulation and acupuncture...
November 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29099679/photobiomodulation-in-neuroscience-a-summary-of-personal-experience
#11
Shimon Rochkind
OBJECTIVE: This review summarizes personal experience with laser photobiomodulation and its potentials for the treatment of peripheral and central nerve system injuries. METHODS AND RESULTS: Laser photobiomodulation was shown to induce nerve cell activation, have a positive effect on metabolism of the nerve cells, and to stimulate nerve sprouting processes. Studies investigating the effects of laser photobiomodulation on injured peripheral nerves in rats reported immediate protective effects which increase the functional activity of the nerve, decrease or prevent scar tissue formation at the injured site, prevent or decrease degeneration in corresponding motor neurons of the spinal cord, and significantly increase axonal growth and myelinization...
November 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29089215/experiences-of-persons-with-spinal-cord-injury-undertaking-a-physical-activity-programme-as-part-of-the-scipa-full-on-randomized-controlled-trial
#12
Allyson Calder, Jo Nunnerley, Hilda Mulligan, Nordawama Ahmad Ali, Gemma Kensington, Tim McVicar, Olivia van Schaik
BACKGROUND: For individuals with spinal cord injury the long term benefits of physical activity are well documented, however the majority of this population report inactivity secondary to participatory barriers. Research investigating physically intensive exercise programs for people with spinal cord injury is limited, with even less attention paid to the experience of the participants. OBJECTIVE: To explore the experiences of persons with spinal cord injury of their participation in the New Zealand arm of the Spinal Cord Injury and Physical Activity (SCIPA) 'Full-On' randomized controlled trial...
October 23, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29081250/effects-of-training-intensity-on-locomotor-performance-in-individuals-with-chronic-spinal-cord-injury-a-randomized-crossover-study
#13
Gabrielle Brazg, Meghan Fahey, Carey L Holleran, Mark Connolly, Jane Woodward, Patrick W Hennessy, Brian D Schmit, T George Hornby
BACKGROUND: Many physical interventions can improve locomotor function in individuals with motor incomplete spinal cord injury (iSCI), although the training parameters that maximize recovery are not clear. Previous studies in individuals with other neurologic injuries suggest the intensity of locomotor training (LT) may positively influence walking outcomes. However, the effects of intensity during training of individuals with iSCI have not been tested. OBJECTIVE: The purpose of this pilot, blinded-assessor randomized trial was to evaluate the effects of LT intensity on walking outcomes in individuals with iSCI...
October 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29067867/comparison-of-transcutaneous-electrical-nerve-stimulation-tens-and-functional-electrical-stimulation-fes-for-spasticity-in-spinal-cord-injury-a-pilot-randomized-cross-over-trial
#14
Anjali Sivaramakrishnan, John M Solomon, Natarajan Manikandan
OBJECTIVE: Spasticity following spinal cord injury (SCI) can impair function and affect quality of life. This study compared the effects of transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) on lower limb spasticity in patients with SCI. DESIGN: Double blind randomized crossover design. SETTING: Neuro-rehabilitation unit, Manipal University, India. PARTICIPANTS: Ten participants (age: 39 ± 13...
October 25, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29065788/walking-speed-is-not-the-best-outcome-to-evaluate-the-effect-of-robotic-assisted-gait-training-in-people-with-motor-incomplete-spinal-cord-injury-a-systematic-review-with-meta-analysis
#15
Ana Valeria Aguirre-Güemez, Aberto Isaac Pérez-Sanpablo, Jimena Quinzaños-Fresnedo, Ramiro Pérez-Zavala, Aída Barrera-Ortiz
Context While there are previous systematic reviews on the effectiveness of the use of robotic-assisted gait training (RAGT) in people with spinal cord injuries (SCI), as this is a dynamic field, new studies have been produced that are now incorporated on this systematic review (SR) with meta-analysis, updating the available evidence on this area. Objective To synthesise the available evidence on the use of RAGT, to improve gait, strength and functioning. Methods SR and meta-analysis following the Cochrane Handbook for Systematic Reviews of Interventions were implemented...
October 25, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29058553/effects-of-body-weight-support-treadmill-training-on-postural-sway-and-gait-independence-in-patients-with-chronic-spinal-cord-injury
#16
Felipe Covarrubias-Escudero, Gonzalo Rivera-Lillo, Rodrigo Torres-Castro, Gonzalo Varas-Díaz
OBJECTIVE: To examine the effects of a six-week body weight-support treadmill training (BWSTT) program on center-of-mass control and gait independence in chronic, incomplete spinal cord injury (iSCI) patients. DESIGN: Descriptive. SETTING: Clinica Los Coihues. Neurorehabilitation center in Santiago, Chile. PARTICIPANTS: 17 chronic iSCI patients and 17 healthy subjects. OUTCOME MEASURES: An instrumented sway (ISway) test was performed before and after the implementation of a six-week BWSTT program...
October 23, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29051134/a-telerehabilitation-approach-to-enhance-quality-of-life-through-exercise-among-adults-with-paraplegia-study-protocol
#17
Shane Norman Sweet, Meredith Rocchi, Kelly Arbour-Nicitopoulos, Dahlia Kairy, Brigitte Fillion
BACKGROUND: Despite compelling evidence linking physical activity and quality of life among adults with spinal cord injury (SCI), exercise participation rates are extremely low in this population. Unfortunately, a lack of behavioral exercise interventions, in particular theory-based randomized controlled trials (RCT), exists within the SCI literature. A pilot RCT is needed to first examine the feasibility to conduct such interventions and determine the appropriate effect size to inform future full-scale interventions...
October 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29037121/predicting-injury-severity-and-neurologic-recovery-after-acute-cervical-spinal-cord-injury-a-comparison-of-cerebrospinal-fluid-and-magnetic-resonance-imaging-biomarkers
#18
Turker Dalkilic, Nader Fallah, Vanessa K Noonan, Sanam Salimi Elizei, Kevin Dong, Lise M Belanger, Leanna Ritchie, Angela Tsang, Etienne Bourassa-Moreau, Manraj K S Heran, Scott J Paquette, Tamir Ailon, Nicolas Dea, John Street, Charles G Fisher, Marcel F Dvorak, Brian K Kwon
Biomarkers of acute human spinal cord injury (SCI) could provide a more objective measure of spinal cord damage and a better predictor of neurologic outcome than the current functional neurologic assessments. There has been growing interest in establishing neurochemical biomarkers using cerebrospinal fluid (CSF) and also imaging biomarkers using measurable features on MRI. In this study, we took the opportunity to compare CSF biomarkers and MRI biomarkers in a cohort of acute cervical SCI patients who had undergone both CSF sampling and pre-operative MRI scanning...
October 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29017505/study-protocol-patient-reported-outcomes-for-bladder-management-strategies-in-spinal-cord-injury
#19
Darshan P Patel, Sara M Lenherr, John T Stoffel, Sean P Elliott, Blayne Welk, Angela P Presson, Amitabh Jha, Jeffrey Rosenbluth, Jeremy B Myers
BACKGROUND: The majority of spinal cord injury (SCI) patients have urinary issues, such as incontinence, retention, and frequency. These problems place a significant burden on patients' physical health and quality of life (QoL). There are a wide variety of bladder management strategies available to patients with no clear guidelines on appropriate selection. Inappropriate bladder management can cause hospitalizations and serious complications, such as urosepsis and renal failure. Patients believe that both independence and ability to carry out daily activities are just as important as physical health in selecting the right bladder-management strategy but little is known about patient's QoL with different bladder managements...
October 10, 2017: BMC Urology
https://www.readbyqxmd.com/read/28994415/sci-peer-health-coach-influence-on-self-management-with-peers-a-qualitative-analysis
#20
S E Skeels, D Pernigotti, B V Houlihan, T Belliveau, M Brody, J Zazula, S Hasiotis, S Seetharama, D Rosenblum, A Jette
STUDY DESIGN: A process evaluation of a clinical trial. OBJECTIVES: To describe the roles fulfilled by peer health coaches (PHCs) with spinal cord injury (SCI) during a randomized controlled trial research study called 'My Care My Call', a novel telephone-based, peer-led self-management intervention for adults with chronic SCI 1+ years after injury. SETTING: Connecticut and Greater Boston Area, MA, USA. METHODS: Directed content analysis was used to qualitatively examine information from 504 tele-coaching calls, conducted with 42 participants with SCI, by two trained SCI PHCs...
November 2017: Spinal Cord
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