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Spinal cord injury trials

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https://www.readbyqxmd.com/read/28414254/lifestyle-intervention-for-adults-with-spinal-cord-injury-results-of-the-usc-rlanrc-pressure-ulcer-prevention-study
#1
Mike Carlson, Cheryl Lp Vigen, Salah Rubayi, Erna Imperatore Blanche, Jeanine Blanchard, Michal Atkins, Barbara Bates-Jensen, Susan L Garber, Elizabeth A Pyatak, Jesus Diaz, Lucia I Florindez, Joel W Hay, Trudy Mallinson, Jennifer B Unger, Stanley Paul Azen, Michael Scott, Alison Cogan, Florence Clark
CONTEXT/OBJECTIVE: Medically serious pressure injuries (MSPrIs), a common complication of spinal cord injury (SCI), have devastating consequences on health and well-being and are extremely expensive to treat. We aimed to test the efficacy of a lifestyle-based intervention designed to reduce incidence of MSPrIs in adults with SCI. DESIGN: A randomized controlled trial (RCT), and a separate study wing involving a nonrandomized standard care control group. SETTING: Rancho Los Amigos National Rehabilitation Center, a large facility serving ethnically diverse, low income residents of Los Angeles County...
April 17, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28413945/body-machine-interface-enables-people-with-cervical-spinal-cord-injury-to-control-devices-with-available-body-movements-proof-of-concept
#2
Farnaz Abdollahi, Ali Farshchiansadegh, Camilla Pierella, Ismael Seáñez-González, Elias Thorp, Mei-Hua Lee, Rajiv Ranganathan, Jessica Pedersen, David Chen, Elliot Roth, Maura Casadio, Ferdinando Mussa-Ivaldi
This study tested the use of a customized body-machine interface (BoMI) for enhancing functional capabilities in persons with cervical spinal cord injury (cSCI). The interface allows people with cSCI to operate external devices by reorganizing their residual movements. This was a proof-of-concept phase 0 interventional nonrandomized clinical trial. Eight cSCI participants wore a custom-made garment with motion sensors placed on the shoulders. Signals derived from the sensors controlled a computer cursor. A standard algorithm extracted the combinations of sensor signals that best captured each participant's capacity for controlling a computer cursor...
May 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28398967/current-trends-in-exercise-intervention-research-technology-and-behavioral-change-strategies-for-people-with-disabilities-a-scoping-review
#3
Byron Lai, Hui-Ju Young, C Scott Bickel, Robert W Motl, James H Rimmer
This review synthesized physical activity and exercise intervention literature for the past 10 yrs for people with physical and cognitive disabilities including intervention characteristics, behavior change strategies, and types of technologies used to improve targeted outcomes. Systematic searches yielded 132 eligible studies. The major disability groups were multiple sclerosis (41%), stroke (15%), and spinal cord injury (12%). Research designs primarily involved randomized controlled trials (61%) versus quasi-experimental designs (39%)...
April 8, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28398300/is-body-weight-supported-treadmill-training-or-robotic-assisted-gait-training-superior-to-overground-gait-training-and-other-forms-of-physiotherapy-in-people-with-spinal-cord-injury-a-systematic-review
#4
REVIEW
J Mehrholz, L A Harvey, S Thomas, B Elsner
STUDY DESIGN: Systematic review about randomised trials comparing different training strategies to improve gait in people with spinal cord injuries (SCI). OBJECTIVES: The aim of this systematic review was to compare the effectiveness of body-weight-supported treadmill training (BWSTT) and robotic-assisted gait training with overground gait training and other forms of physiotherapy in people with traumatic SCI. SETTING: Systematic review conducted by researchers from Germany and Australia...
April 11, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28393423/are-midsagittal-tissue-bridges-predictive-of-outcome-after-cervical-spinal-cord-injury
#5
Eveline Huber, Patrice Lachappelle, Reto Sutter, Armin Curt, Patrick Freund
T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At one month post-injury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at one month post-injury were associated with neurological and functional recovery at 1 year follow-up...
April 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28382211/paraplegia-and-transtibial-amputation-successful-ambulation-after-dual-disability-a-retrospective-case-report
#6
Thangavelu Senthilvelkumar, Bobeena R Chandy
INTRODUCTION: This is a single-subject case report. The objective is to describe the unique rehabilitation outcome of an individual with motor complete T12 paraplegia and a right transtibial amputation. This study was conducted at the Department of Physical Medicine and Rehabilitation of Christian Medical College in India. CASE PRESENTATION: A 42-year-old policeman presented to our rehabilitation centre with motor complete T12 paraplegia and right transtibial amputation, 3 months following a road traffic accident...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28377392/effects-of-testosterone-and-evoked-resistance-exercise-after-spinal-cord-injury-terex-sci-study-protocol-for-a-randomised-controlled-trial
#7
Ashraf S Gorgey, Refka E Khalil, Ranjodh Gill, Laura C O'Brien, Timothy Lavis, Teodoro Castillo, David X Cifu, Jeannie Savas, Rehan Khan, Christopher Cardozo, Edward J Lesnefsky, David R Gater, Robert A Adler
INTRODUCTION: Individuals with spinal cord injury (SCI) are at a lifelong risk of obesity and chronic metabolic disorders including insulin resistance and dyslipidemia. Within a few weeks of injury, there is a significant decline in whole body fat-free mass, particularly lower extremity skeletal muscle mass, and subsequent increase in fat mass (FM). This is accompanied by a decrease in anabolic hormones including testosterone. Testosterone replacement therapy (TRT) has been shown to increase skeletal muscle mass and improve metabolic profile...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28363483/restoration-of-reaching-and-grasping-movements-through-brain-controlled-muscle-stimulation-in-a-person-with-tetraplegia-a-proof-of-concept-demonstration
#8
A Bolu Ajiboye, Francis R Willett, Daniel R Young, William D Memberg, Brian A Murphy, Jonathan P Miller, Benjamin L Walter, Jennifer A Sweet, Harry A Hoyen, Michael W Keith, P Hunter Peckham, John D Simeral, John P Donoghue, Leigh R Hochberg, Robert F Kirsch
BACKGROUND: People with chronic tetraplegia, due to high-cervical spinal cord injury, can regain limb movements through coordinated electrical stimulation of peripheral muscles and nerves, known as functional electrical stimulation (FES). Users typically command FES systems through other preserved, but unrelated and limited in number, volitional movements (eg, facial muscle activity, head movements, shoulder shrugs). We report the findings of an individual with traumatic high-cervical spinal cord injury who coordinated reaching and grasping movements using his own paralysed arm and hand, reanimated through implanted FES, and commanded using his own cortical signals through an intracortical brain-computer interface (iBCI)...
March 28, 2017: Lancet
https://www.readbyqxmd.com/read/28350947/traumatic-spinal-cord-injury-repair-and-regeneration
#9
Christopher S Ahuja, Satoshi Nori, Lindsay Tetreault, Jefferson Wilson, Brian Kwon, James Harrop, David Choi, Michael G Fehlings
BACKGROUND: Traumatic spinal cord injuries (SCI) have devastating consequences for the physical, financial, and psychosocial well-being of patients and their caregivers. Expediently delivering interventions during the early postinjury period can have a tremendous impact on long-term functional recovery. PATHOPHYSIOLOGY: This is largely due to the unique pathophysiology of SCI where the initial traumatic insult (primary injury) is followed by a progressive secondary injury cascade characterized by ischemia, proapoptotic signaling, and peripheral inflammatory cell infiltration...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28342829/effects-of-peer-mentoring-on-self-efficacy-and-hospital-readmission-following-inpatient-rehabilitation-of-individuals-with-spinal-cord-injury-a-randomized-controlled-trial
#10
Julie Gassaway, Michael L Jones, W Mark Sweatman, Minna Hong, Peter Anziano, Karen DeVault
OBJECTIVE: Investigate the effect of intensive peer mentoring on patient reported outcomes of self-efficacy and unplanned hospital readmissions for persons with spinal cord injury/disease (SCI/D) within the first 6 months after discharge from inpatient rehabilitation DESIGN: Randomized controlled trial; SETTING: Non-profit inpatient rehabilitation hospital specializing in care of persons with SCI/D and brain injury PARTICIPANTS: 158 patients admitted to the SCI rehabilitation program whose discharge location was a community setting...
March 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28341580/efficacy-and-safety-of-sildenafil-in-men-with-sexual-dysfunction-and-spinal-cord-injury
#11
REVIEW
Dana A Ohl, Martin Carlsson, Vera J Stecher, Gregory A Rippon
INTRODUCTION: Spinal cord injury (SCI) is estimated to affect approximately 276,000 individuals in the United States. Since 2010, the mean age of individuals at the time of the SCI has been 42 years, with nearly 80% of cases involving men. This means that individuals with SCI generally are young men who typically place a great deal of importance on normal sexual and reproductive function. AIM: To assess the effect of sildenafil treatment on erectile function and the frequency of ejaculation in men with SCI...
March 21, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28339391/topical-ketamine-10-for-neuropathic-pain-in-spinal-cord-injury-patients-an-open-label-trial
#12
Joseph Rabi, Joshua Minori, Hasan Abad, Ray Lee, Michelle Gittler
Topical ketamine, an N-methyl-D-aspartate antagonist, has been shown to be effective in certain neuropathic pain syndromes. The objective of this study was to determine the efficacy of topical ketamine in spinal cord injury patients with neuropathic pain. An open label trial enrolled five subjects at an outpatient rehabilitation hospital with traumatic spinal cord injuries who had neuropathic pain at or below the level of injury. Subjects applied topical ketamine 10% three times a day for a two-week duration...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28330471/robot-assisted-gait-training-lokomat-improves-walking-function-and-activity-in-people-with-spinal-cord-injury-a-systematic-review
#13
REVIEW
Ki Yeun Nam, Hyun Jung Kim, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Aeri Yoo
Robot-assisted gait training (RAGT) after spinal cord injury (SCI) induces several different neurophysiological mechanisms to restore walking ability, including the activation of central pattern generators, task-specific stepping practice and massed exercise. However, there is no clear evidence for the optimal timing and efficacy of RAGT in people with SCI. The aim of our study was to assess the effects of RAGT on improvement in walking-related functional outcomes in patients with incomplete SCI compared with other rehabilitation modalities according to time elapsed since injury...
March 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28323088/localization-of-the-corticospinal-tract-within-the-porcine-spinal-cord-implications-for-experimental-modeling-of-traumatic-spinal-cord-injury
#14
Anna Victoria Leonard, Joshua York Menendez, Betty Maki Pat, Mark N Hadley, Candace Lorraine Floyd
Spinal cord injury (SCI) researchers have predominately utilized rodents for SCI modeling and experimentation. Unfortunately, a large number of novel therapies developed in rodent models have failed to demonstrate efficacy in human clinical trials which suggests that improved animal models are an important translational tool. Recently, porcine models of SCI have been identified as a valuable intermediary model for preclinical evaluation of promising therapies to aid clinical translation. However, the localization of the major spinal tracts in pigs has not yet been described...
March 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28322239/spinal-cord-ability-ruler-an-interval-scale-to-measure-volitional-performance-after-spinal-cord-injury
#15
R Reed, M Mehra, S Kirshblum, D Maier, D Lammertse, A Blight, R Rupp, L Jones, R Abel, N Weidner, A Curt, J Steeves
STUDY DESIGN: Retrospective statistical analysis of database. OBJECTIVE: Spinal cord injury (SCI) clinical trials are challenged to enroll participants, and early trial outcomes have often been equivocal. We hypothesized that a specifically designed novel true linear interval-scaled outcome measure targeted to simultaneously track a broad range of SCI will enable more inclusive enrollment of participants and valid comparisons of functional changes after SCI. METHODS: To define a single SCI measurement framework, we used items from existing measures...
March 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28306581/spinal-cord-stimulation-treatment-for-persistent-pain-after-a-burn-injury-a-case-report
#16
Takeshi Kubota, Yuuhei Ishikawa, Rie Ishikawa
Spinal cord stimulation (SCS) is used to treat neuropathic pain, but there are no published studies on its use to treat burn pain. We used SCS to treat a 67-year-old man suffering from burn pain that could not be managed with high-dose opioids or adjuvant neuropathic analgesics. A trial of SCS markedly reduced the visual analog scale score for pain in the left lateral abdominal and gluteal regions. He underwent permanent implantation of a SCS and achieved an opioid-free state. This case suggests that SCS treatment is a therapeutic option for burn pain refractory to conventional therapy...
March 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28306359/spinal-cord-injuries-how-could-cell-therapy-help
#17
Anna Badner, Ahad M Siddiqui, Michael G Fehlings
Spinal cord injury (SCI) is a devastating condition, where regenerative failure and cell loss lead to paralysis. The heterogeneous and time-sensitive pathophysiology has made it difficult to target tissue repair. Despite many medical advances, there are no effective regenerative therapies. As stem cells offer multi-targeted and environmentally responsive benefits, cell therapy is a promising treatment approach. Areas covered: This review highlights the cell therapies being investigated for SCI, including Schwann cells, olfactory ensheathing cells, mensenchymal stem/stromal cells, neural precursors, oligodendrocyte progenitors, embryonic stem cells, and induced pluripotent stem cells...
March 27, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28298927/therapeutic-potential-of-olfactory-ensheathing-cells-and-mesenchymal-stem-cells-in-spinal-cord-injuries
#18
REVIEW
Zadroga Anna, Jezierska-Woźniak Katarzyna, Czarzasta Joanna, Monika Barczewska, Wojtkiewicz Joanna, Maksymowicz Wojciech
Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28296754/effects-of-aquatic-exercise-on-physical-function-and-fitness-among-people-with-spinal-cord-injury-a-systematic-review
#19
REVIEW
Chunxiao Li, Selina Khoo, Athirah Adnan
OBJECTIVE: The aim of this review is to synthesize the evidence on the effects of aquatic exercise interventions on physical function and fitness among people with spinal cord injury. DATA SOURCE: Six major databases were searched from inception till June 2015: MEDLINE, CINAHL, EMBASE, PsychInfo, SPORTDiscus, and Cochrane Center Register of Controlled Trials. STUDY APPRAISAL AND SYNTHESIS METHODS: Two reviewers independently rated methodological quality using the modified Downs and Black Scale and extracted and synthesized key findings (i...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28290147/temporal-profile-and-severity-correlation-of-a-panel-of-rat-spinal-cord-injury-protein-biomarkers
#20
Zhihui Yang, Helen M Bramlett, Ahmed Moghieb, Dongnan Yu, Ping Wang, Fan Lin, Carl Bauer, Tyler M Selig, Emily Jaalouk, Amanda S Weissman, Disa S Rathore, Pammela Romo, Zhiqun Zhang, Ronald L Hayes, Michael Y Wang, W Dalton Dietrich, Kevin K W Wang
In the USA, there are approximately 12,000 new cases of spinal cord injury (SCI) each year and some 1.2 million people living with paralysis due to SCI. Seven percent of them are paralyzed due to an accident or injury occurring while serving in the military. Here, we report a systematic study on protein biomarker candidates in a rat SCI model with either moderate or severe injury. Tissue, cerebrospinal fluid (CSF), and serum samples were obtained at 4 h, 24 h, and 7 days post-injury. The candidate biomarkers included axonal injury markers αII-spectrin breakdown products (SBDP150/145/120), neuronal cell body injury marker ubiquitin C-terminal hydrolase-L1 (UCH-L1), astrogliosis/astroglial injury markers S100 calcium-binding protein-β (S100β), glial fibrillary acidic protein (GFAP) and GFAP breakdown products (GBDPs), demyelination marker myelin basic protein (MBP), axonal injury marker phosphorylated neurofilament-H (pNF-H), and neuroinflammation marker interleukin-6 (IL-6)...
March 13, 2017: Molecular Neurobiology
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