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Spinal cord injury trials

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https://www.readbyqxmd.com/read/28816990/a-randomized-controlled-trial-of-botulinum-toxin-a-for-treating-neuropathic-pain-in-patients-with-spinal-cord-injury-retraction
#1
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No abstract text is available yet for this article.
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816870/spinal-cord-injury-what-are-the-controversies
#2
Christopher S Ahuja, Gregory D Schroeder, Alexander R Vaccaro, Michael G Fehlings
Traumatic spinal cord injuries have a tremendous impact on individuals, families, and society as a whole. Substantial heterogeneity in the patient population, their presentation and underlying pathophysiology has sparked debates along the care spectrum from initial assessment to definitive treatment. This article reviews spinal cord injury (SCI) management followed by a discussion of the salient controversies in the field. Current care practices modeled on the American Association of Neurological Surgeons/Congress of Neurological Surgeons joint section guidelines are highlighted including key recommendations regarding immobilization, avoidance of hypotension, early International Standards for Neurological Classification of SCI examination and intensive care unit treatment...
September 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28809389/cost-effectiveness-analysis-of-telephone-based-support-for-the-management-of-pressure-ulcers-in-people-with-spinal-cord-injury-in-india-and-bangladesh
#3
M Arora, L A Harvey, J V Glinsky, H S Chhabra, M S Hossain, N Arumugam, P K Bedi, I D Cameron, A J Hayes
OBJECTIVE: To determine from a societal perspective the cost-effectiveness and cost-utility of telephone-based support for management of pressure ulcers. STUDY DESIGN: Cost-effectiveness and cost-utility analysis of a randomised clinical trial. SETTING: Tertiary centre in India and Bangladesh. METHODS: An economic evaluation was conducted alongside a randomised clinical trial comparing 12 weeks of telephone-based support (intervention group) with usual care (control group)...
August 15, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28794901/a-randomized-controlled-trial-to-test-the-efficacy-of-the-sci-get-fit-toolkit-on-leisure-time-physical-activity-behaviour-and-social-cognitive-processes-in-adults-with-spinal-cord-injury
#4
Kelly P Arbour-Nicitopoulos, Shane N Sweet, Marie-Eve Lamontagne, Kathleen A Martin Ginis, Samantha Jeske, François Routhier, Amy E Latimer-Cheung
STUDY DESIGN: Single blind, two-group randomized controlled trial. OBJECTIVES: To evaluate the efficacy of the SCI Get Fit Toolkit delivered online on theoretical constructs and moderate-to-vigorous physical activity (MVPA) among adults with SCI. SETTING: Ontario and Quebec, Canada. ELIGIBILITY: Inactive, English- and French-speaking Canadian adults with traumatic SCI with Internet access, and no self-reported cognitive or memory impairments...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28770686/body-composition-changes-with-testosterone-replacement-therapy-following-spinal-cord-injury-and-aging-a-mini-review
#5
Tom E Nightingale, Pamela Moore, Joshua Harman, Refka Khalil, Ranjodh S Gill, Teodoro Castillo, Robert A Adler, Ashraf S Gorgey
Context Hypogonadism is a male clinical condition in which the body does not produce enough testosterone. Testosterone plays a key role in maintaining body composition, bone mineral density, sexual function, mood, erythropoiesis, cognition and quality of life. Hypogonadism can occur due to several underlying pathologies during aging and in men with physical disabilities, such as spinal cord injury (SCI). This condition is often under diagnosed and as a result, symptoms undertreated. Methods In this mini-review, we propose that testosterone replacement therapy (TRT) may be a viable strategy to improve lean body mass (LBM) and fat mass (FM) in men with SCI...
August 3, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28760862/myelinogenic-plasticity-of-oligodendrocyte-precursor-cells-following-spinal-cord-contusion-injury
#6
P Assinck, G J Duncan, J R Plemel, M J Lee, J S Stratton, S B Manesh, J Liu, L M Ramer, S H Kang, D E Bergles, J Biernaskie, W Tetzlaff
Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin repair and identity of the cells responsible remain incompletely understood and contentious. We assessed the cellular origin of new myelin by fate mapping PDGFRα+, Olig2+, and P0+ cells following contusion SCI in mice. Oligodendrocyte precursor cells (OPCs; PDGFRα+) produced oligodendrocytes responsible for de novo ensheathment of ∼30% of myelinated spinal axons at injury epicenter three months after SCI, demonstrating that these resident cells are a major contributor to oligodendrocyte regeneration...
July 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28758117/neurocardiology-cardiovascular-changes-and-specific-brain-region-infarcts
#7
REVIEW
Rongjun Zou, Wanting Shi, Jun Tao, Hongmu Li, Xifeng Lin, Songran Yang, Ping Hua
There are complex and dynamic reflex control networks between the heart and the brain, including cardiac and intrathoracic ganglia, spinal cord, brainstem, and central nucleus. Recent literature based on animal model and clinical trials indicates a close link between cardiac function and nervous systems. It is noteworthy that the autonomic nervous-based therapeutics has shown great potential in the management of atrial fibrillation, ventricular arrhythmia, and myocardial remodeling. However, the potential mechanisms of postoperative brain injury and cardiovascular changes, particularly heart rate variability and the presence of arrhythmias, are not understood...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28755491/systematic-review-of-psychosocial-interventions-for-people-with-spinal-cord-injury-during-inpatient-rehabilitation-implications-for-evidence-based-practice
#8
Yan Li, Daniel Bressington, Wai Tong Chien
BACKGROUND: The bio-psychosocial model of spinal cord injury (SCI) highlights that psychosocial care is of equal importance as physical rehabilitation, and should be offered in the earlier stages of inpatient rehabilitation. AIM: This systematic review aimed to identify interventional research regarding psychosocial care for people with SCI during inpatient rehabilitation and synthesize the evidence of the effects and characteristics of these studies. METHODS: A systematic search of relevant literature published between 1985 to July 2016 was conducted with six databases (Scopus, MEDLINE, CINAHL, Science Citation Index Expanded, PsycINFO, and the China Academic Journal Full-text Database)...
July 29, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28751267/detrusor-contraction-during-rapid-bladder-filling-caused-by-cold-or-warm-water-a-randomized-controlled-double-blind-trial
#9
Marko Kozomara, Ulrich Mehnert, Burkhardt Seifert, Thomas M Kessler
PURPOSE: We investigated if the detrusor contraction during rapid bladder filling is provoked by cold or warm water. PATIENTS & METHODS: Patients suffering from neurogenic lower urinary tract dysfunction (NLUTD) were included into this randomized controlled double-blind trial. At the end of standard urodynamic investigation, the patients received 2 fillings of the bladder using a 4°C (ice water test, IWT) or 36°C (warm water test, WWT) saline solution with a speed of 100 mL/min...
July 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28738740/a-systematic-review-of-the-effectiveness-of-task-specific-rehabilitation-interventions-for-improving-independent-sitting-and-standing-function-in-spinal-cord-injury
#10
Cynthia M Tse, Amanda E Chisholm, Tania Lam, Janice J Eng
Context Impaired balance function after a spinal cord injury (SCI) hinders performance of daily activities. Objective To assess the evidence on the effectiveness of task-specific training on sitting and standing function in individuals with SCI across the continuum of care. Methods A systematic search was conducted on literature published to June 2016 using people (acute or chronic SCI), task-specific interventions compared to conventional physical therapy, and outcome (sitting or standing balance function)...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28723381/efficacy-and-safety-of-onabotulinumtoxina-in-patients-with-urinary-incontinence-due-to-neurogenic-detrusor-overactivity-update-of-the-pivotal-randomised-double-blind-placebo-controlled-trials
#11
Carlos Martins-Silva, Francisco Cruz
Bladder injections of 200U onabotulinumtoxinA have similar efficacy in the treatment of urinary incontinence in patients with multiple sclerosis or spinal cord injury. The effect is maintained in the long term without significant adverse events.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720322/rodent-large-animal-and-non-human-primate-models-of-spinal-cord-injury
#12
REVIEW
Raffaele Nardone, Cristina Florea, Yvonne Höller, Francesco Brigo, Viviana Versace, Piergiorgio Lochner, Stefan Golaszewski, Eugen Trinka
In this narrative review we aimed to assess the usefulness of the different animal models in identifying injury mechanisms and developing therapies for humans suffering from spinal cord injury (SCI). Results obtained from rodent studies are useful but, due to the anatomical, molecular and functional differences, confirmation of these findings in large animals or non-human primates may lead to basic discoveries that cannot be made in rodent models and that are more useful for developing treatment strategies in humans...
June 21, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28708753/effectiveness-of-preoperative-intranasal-dexmedetomidine-compared-with-oral-midazolam-for-the-prevention-of-emergence-delirium-in-the-pediatric-patient-undergoing-general-anesthesia-a-systematic-review
#13
James FitzSimons, Laura S Bonanno, Stephanie Pierce, Jennifer Badeaux
BACKGROUND: Emergence delirium is defined as a cognitive disturbance during emergence from general anesthesia resulting in hallucinations, delusions and confusion manifested by agitation, restlessness, involuntary physical movement and extreme flailing in bed. Postoperative emergence delirium develops in 12% to 18% of all children undergoing general anesthesia for surgery. This post-anesthetic phenomenon changes cognitive and psychomotor behavior, and puts pediatric patients and health care personnel at risk of injury...
July 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28706615/novel-effects-of-traditional-wooden-toothbrush-on-bowel-motility-symptoms-in-spinal-cord-injury-patients-findings-from-a-pilot-quasi-experimental-study
#14
Ebrahim Esfandiari, Awat Feizi, Zahra Heidari, Seyed Reza Tabibian, Pooria Shaabani, Bijan Iraj, Payman Adibi, Amrollah Ebrahimi Varzaneh
BACKGROUND: The aim of this study was to investigate the therapeutic effect of traditional wooden toothbrush usage on most severe constipation, which usually occurs in spinal cord injury (SCI) patients. METHODS: In a quasi-experimental study, 61 SCI patients were selected who had injuries in different spinal levels (cervical, thoracic, and lumbar), and severe constipation from one defection in a few days to 3 weeks. They were recommended to use traditional wooden toothbrush for 5 min twice a day, after breakfast and dinner, over a 6 weeks period...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28703038/rehabilitation-interventions-to-modify-endocrine-metabolic-disease-risk-in-individuals-with-chronic-spinal-cord-injury-living-in-the-community-riisc-a-systematic-review-and-scoping-perspective
#15
Jenna C Gibbs, Dany H Gagnon, Austin J Bergquist, Jasmine Arel, Tomas Cervinka, Rasha El-Kotob, Désirée B Maltais, Dalton L Wolfe, B Catharine Craven
Context Endocrine-metabolic disease (EMD) risk following spinal cord injury (SCI) is associated with significant multi-morbidity (i.e. fracture, diabetes, heart disease), mortality, and economic burden. It is unclear to what extent rehabilitation interventions can modify EMD risk and improve health status in community-dwelling adults with chronic SCI. Objectives To characterize rehabilitation interventions and summarize evidence on their efficacy/effectiveness to modify precursors to EMD risk in community-dwelling adults with chronic SCI...
July 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28701540/a-novel-paraplegia-model-in-awake-behaving-macaques
#16
Max Ostrinsky Krucoff, Katie Zhuang, David B Macleod, Allen Yin, Yoon Woo Byun, Roberto Jose Manson, Dennis A Turner, Laura Oliveira, Mikhail A Lebedev
Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable non-human primate model for paraplegia hinders their advancement. Therefore, our multi-disciplinary team developed a way to induce temporary paralysis in awake behaving macaques by creating a fully implantable lumbar epidural catheter-subcutaneous port system that enables easy and reliable targeted drug delivery for sensorimotor blockade...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28693585/controlled-automated-reperfusion-of-the-whole-body-after-120%C3%A2-minutes-of-cardiopulmonary-resuscitation-first-clinical-report
#17
Georg Trummer, Alexander Supady, Friedhelm Beyersdorf, Christian Scherer, Tobias Wengenmayer, Markus Umhau, Christoph Benk
BACKGROUND: Cardiopulmonary resuscitation (CPR) is associated with a high mortality rate. Furthermore, the few survivors often have severe, persistent cerebral dysfunction. A potential cause for this unsatisfactory outcome after CPR is the combination of cardiac arrest (ischemia) and the inability to restore adequate hemodynamics during conventional CPR (reperfusion), resulting in ischemia/reperfusion injury of the whole body. Therefore we developed a concept counteracting this ischemia/reperfusion injury during the process of CPR...
July 10, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28690497/high-amplitude-eeg-motor-potential-during-repetitive-foot-movement-possible-use-and-challenges-for-futuristic-bcis-that-restore-mobility-after-spinal-cord-injury
#18
Aljoscha Thomschewski, Yvonne Höller, Peter Höller, Stefan Leis, Eugen Trinka
Recent advances in neuroprostheses provide us with promising ideas of how to improve the quality of life in people suffering from impaired motor functioning of upper and lower limbs. Especially for patients after spinal cord injury (SCI), futuristic devices that are controlled by thought via brain-computer interfaces (BCIs) might be of tremendous help in managing daily tasks and restoring at least some mobility. However, there are certain problems arising when trying to implement BCI technology especially in such a heterogenous patient group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28673884/serum-concentrations-of-fibrinogen-in-patients-with-spinal-cord-injury-and-its-relationship-with-neurological-function
#19
Jia-Ming Liu, Min Lan, Yang Zhou, Xuan-Yin Chen, Shan-Hu Huang, Zhi-Li Liu
BACKGROUND: Many studies have focused on the axons regeneration after spinal cord injury (SCI). And fibrinogen was reported to be an inhibitory factor for axons regeneration. However, most of these studies were based on animal experiments and in vitro trials. Few studies reported serum concentrations of fibrinogen in patients with SCI. OBJECTIVE: To investigate the circulating serum concentrations of fibrinogen in patients with SCI, and to determine the relationship between fibrinogen concentrations and patients' neurological function...
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28673831/risk-factors-for-laryngeal-penetration-aspiration-in-patients-with-acute-traumatic-cervical-spinal-cord-injury
#20
Tiina Ihalainen, Irina Rinta-Kiikka, Teemu M Luoto, Tuomo Thesleff, Mika Helminen, Anna-Maija Korpijaakko-Huuhka, Antti Ronkainen
BACKGROUND CONTEXT: Laryngeal penetration-aspiration, the entry of material into the airways, is considered the most severe subtype of dysphagia and is common among patients with acute cervical spinal cord injury (SCI). PURPOSE: The aim of this study was to investigate risk factors for penetration-aspiration in patients with acute traumatic cervical spinal cord injury (TCSCI). STUDY DESIGN: This is a prospective cohort study. PATIENT SAMPLE: Thirty-seven patients with TCSCI were included in the study...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
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