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Fetal lung maturation

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https://www.readbyqxmd.com/read/27861467/antenatal-dexamethasone-vs-betamethasone-dosing-for-lung-maturation-in-fetal-sheep
#1
Augusto F Schmidt, Matthew W Kemp, Paranthaman S Kannan, Boris W Kramer, John P Newnham, Suhas G Kallapur, Alan H Jobe
BackgroundDexamethasone-phosphate (Dex-PO4) and the combination betamethasone-phosphate (Beta-PO4) + betamethasone-acetate (Beta-Ac) are the most used antenatal corticosteroids to promote fetal lung maturation . We compared fetal lung maturation induced by Beta-Ac+Beta-PO4, Dex-PO4, or Beta-PO4 alone.MethodsPregnant ewes received 2 intramuscular doses 24h apart of 0.25mg/kg/dose of Beta-Ac+Beta-PO4, Dex-PO4 or Beta-PO4; or 2 doses of 0.125mg/kg/dose of Beta-PO4 at 6h, 12h, or 24h intervals. Fetuses were delivered 48h after the first dose and ventilated for 30min...
November 18, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27818799/retracted-antenatal-steroid-therapy-for-fetal-lung-maturation-and-the-subsequent-risk-of-childhood-asthma-a-longitudinal-analysis
#2
Journal Of Pregnancy
[This retracts the article DOI: 10.1155/2010/789748.].
2016: Journal of Pregnancy
https://www.readbyqxmd.com/read/27799556/precise-gene-editing-paves-the-way-for-derivation-of-mannheimia-haemolytica-leukotoxin-resistant-cattle
#3
Sudarvili Shanthalingam, Ahmed Tibary, Jonathan E Beever, Poothapillai Kasinathan, Wendy C Brown, Subramaniam Srikumaran
Signal peptides of membrane proteins are cleaved by signal peptidase once the nascent proteins reach the endoplasmic reticulum. Previously, we reported that, contrary to the paradigm, the signal peptide of ruminant CD18, the β subunit of β2 integrins, is not cleaved and hence remains intact on mature CD18 molecules expressed on the surface of ruminant leukocytes. Leukotoxin secreted by Mannheimia (Pasteurella) haemolytica binds to the intact signal peptide and causes cytolysis of ruminant leukocytes, resulting in acute inflammation and lung tissue damage...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27764015/progesterone-as-a-tocolytic-agent-for-preterm-labor-a-systematic-review
#4
Reshama Navathe, Vincenzo Berghella
PURPOSE OF REVIEW: Tocolytic agents have been used for over 60 years in the fight against preterm labor, which ultimately can lead to preterm birth. Currently, clinicians can choose from a variety of drug classes to achieve the primary goal of delaying delivery by 48 h, thereby allowing time for administration of corticosteroids for fetal lung maturity, and if appropriate, starting magnesium sulfate for fetal neuroprotection. However, there are currently no known therapies to maintain the tocolytic effect beyond those initial 48 h...
December 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27758872/alveolar-macrophage-development-in-mice-requires-l-plastin-for-cellular-localization-and-retention-within-alveoli
#5
Elizabeth M Todd, Julie Y Zhou, Taylor P Szasz, Lauren E Deady, June A D'Angelo, Matthew D Cheung, Alfred H J Kim, Sharon Celeste Morley
Alveolar macrophages are lung-resident sentinel cells that develop perinatally and protect against pulmonary infection. Molecular mechanisms controlling alveolar macrophage generation have not been fully defined. Here we show that the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages. Mice expressing a conditional allele of LPL (CD11c.Cre(pos)-LPL(fl/fl)) exhibited significant reductions in alveolar macrophages and failed to effectively clear pulmonary pneumococcal infection, showing that immunodeficiency results from reduced alveolar macrophage numbers...
October 6, 2016: Blood
https://www.readbyqxmd.com/read/27745655/bisphenol-a-exposure-alters-release-of-immune-and-developmental-modulators-and-expression-of-estrogen-receptors-in-human-fetal-lung-fibroblasts
#6
Laziyan Mahemuti, Qixuan Chen, Melanie C Coughlan, Min Zhang, Maria Florian, Ryan J Mailloux, Xu-Liang Cao, Kylie A Scoggan, William G Willmore, Xiaolei Jin
Bisphenol A (BPA) has been shown to exert biological effects through estrogen receptor (ER)-dependent and ER-independent mechanisms. Recent studies suggest that prenatal exposure to BPA may increase the risk of childhood asthma. To investigate the underlying mechanisms in the actions of BPA, human fetal lung fibroblasts (hFLFs) were exposed to varying doses of BPA in culture for 24hr. Effects of BPA on localization and uptake of BPA, cell viability, release of immune and developmental modulators, cellular localization and expression of ERα, ERβ and G-protein coupled estrogen receptor 30 (GPR30), and effects of ERs antagonists on BPA-induced changes in endothelin-1 (ET-1) release were examined...
October 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27692868/chronic-hypoxaemia-as-a-molecular-regulator-of-fetal-lung-development-implications-for-risk-of-respiratory-complications-at-birth
#7
Erin V McGillick, Sandra Orgeig, Dino A Giussani, Janna L Morrison
Exposure to altered intrauterine conditions during pregnancy influences both fetal growth and organ development. Chronic fetal hypoxaemia is a common pregnancy complication associated with intrauterine growth restriction (IUGR) that may influence the risk of infants experiencing respiratory complications at birth. There are a variety of signalling pathways that contribute to normal fetal lung development at the molecular level. The specific molecular effects of chronic hypoxaemia associated with IUGR on lung development are likely to be dependent on the specific aetiology (maternal, placental and/or fetal factors) that can alter hormone concentrations, oxygen and nutrient transport to the fetus...
August 21, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27677847/a-bioengineered-niche-promotes-in-vivo-engraftment-and-maturation-of-pluripotent-stem-cell-derived-human-lung-organoids
#8
Briana R Dye, Priya H Dedhia, Alyssa J Miller, Melinda S Nagy, Eric S White, Lonnie D Shea, Jason R Spence
Human pluripotent stem cell (hPSC) derived tissues often remain developmentally immature in vitro, and become more adult-like in their structure, cellular diversity and function following transplantation into immunocompromised mice. Previously we have demonstrated that hPSC-derived human lung organoids (HLOs) resembled human fetal lung tissue in vitro (Dye et al., 2015). Here we show that HLOs required a bioartificial microporous poly(lactide-co-glycolide) (PLG) scaffold niche for successful engraftment, long-term survival, and maturation of lung epithelium in vivo...
September 28, 2016: ELife
https://www.readbyqxmd.com/read/27665512/diabetes-in-pregnancy-and-lung-health-in-offspring-developmental-origins-of-respiratory-disease
#9
M B Azad, B L Moyce, L Guillemette, C D Pascoe, B Wicklow, J M McGavock, A J Halayko, V W Dolinsky
Diabetes is an increasingly common complication of pregnancy. In parallel with this trend, a rise in chronic lung disease in children has been observed in recent decades. While several adverse health outcomes associated with exposure to diabetes in utero have been documented in epidemiological and experimental studies, few have examined the impact of diabetes in pregnancy on offspring lung health and respiratory disease. We provide a comprehensive overview of current literature on this topic, finding suggestive evidence that exposure to diabetes in utero may have adverse effects on lung development...
August 19, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27659865/preeclampsia-short-and-long-term-consequences-for-mother-and-neonate
#10
REVIEW
Anouk Bokslag, Mirjam van Weissenbruch, Ben Willem Mol, Christianne J M de Groot
Preeclampsia is a common pregnancy specific disease, that presents with hypertension and a variety of organ failures, including malfunction of kidneys, liver and lungs. At present, the only definitive treatment of preeclampsia is end the pregnancy and deliver the neonate and placenta. For women with mild preeclampsia in the preterm phase of pregnancy, expectant management is generally indicated to improve fetal maturity, often requiring maternal medical treatment. Last decades, more evidence is available that the underlying mechanism of preeclampsia, endothelial disease, is not limited to pregnancy but increases cardiovascular risk in later life...
November 2016: Early Human Development
https://www.readbyqxmd.com/read/27651617/role-of-l-arginine-in-oligohydramnios
#11
Anita Soni, Seeru Garg, Khushboo Patel, Zarna Patel
BACKGROUND: Oligohydramnios is a known obstetric complication which is associated with operative interferences and perinatal morbidity and mortality. l-arginine is a precursor of nitric oxide and may play a role in local vasodilatation. Administration of l-arginine has been suggested to improve amniotic fluid index (AFI) in oligohydramnios. AIMS AND OBJECTIVES: To study the effect of l-arginine in optimizing fetal outcome in cases of oligohydramnios. MATERIALS AND METHODS: A retrospective study was conducted at Dr L H Hiranandani hospital consisting of 100 antenatal patients diagnosed with oligohydramnios [AFI < 8 cm] remote from term...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27636897/antenatal-corticosteroids-and-the-renin-angiotensin-aldosterone-system-in-adolescents-born-preterm
#12
Andrew M South, Patricia A Nixon, Mark C Chappell, Debra I Diz, Gregory B Russell, Beverly M Snively, Hossam A Shaltout, James C Rose, T Michael O'Shea, Lisa K Washburn
BACKGROUND: Antenatal corticosteroid (ANCS) treatment hastens fetal lung maturity and improves survival of premature infants, but the long-term effects of ANCS are not well-described. Animal models suggest that ANCS increases the risk of cardiovascular disease through programmed changes in the renin-angiotensin (Ang)-aldosterone system (RAAS). We hypothesized that ANCS exposure alters the RAAS in adolescents born prematurely. METHODS: A cohort of 173 adolescents born prematurely was evaluated, of whom 92 were exposed to ANCS...
October 5, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27629593/fetal-to-maternal-signaling-in-the-timing-of-birth
#13
Carole R Mendelson, Alina P Montalbano, Lu Gao
Preterm birth remains the major cause of neonatal morbidity and mortality throughout the world. This is due, in part, to our incomplete understanding of the mechanisms that underlie the maintenance of pregnancy and the initiation of parturition at term. In this article, we review our current knowledge of the complex, interrelated and concerted mechanisms whereby progesterone maintains myometrial quiescence throughout most of pregnancy, as well as those that mediate the upregulation of the inflammatory response and decline in progesterone receptor function leading to parturition...
September 11, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27614961/inhaled-vitamin-d-a-novel-strategy-to-enhance-neonatal-lung-maturation
#14
Sneha K Taylor, Reiko Sakurai, Tokusho Sakurai, Virender K Rehan
INTRODUCTION: The physiologic vitamin D (VD), 1α,25(OH)2D3 (1,25D) is a local paracrine/autocrine effecter of fetal lung maturation. By stimulating alveolar type II cell and lipofibroblast proliferation and differentiation, parenterally administered 1,25D has been shown to enhance neonatal lung maturation; but due to the potential systemic side effects of the parenteral route, the translational value of these findings might be limited. To minimize the possibility of systemic toxicity, we examined the effects of VD on neonatal lung maturation, when delivered directly to lungs via nebulization...
December 2016: Lung
https://www.readbyqxmd.com/read/27591320/fetal-cd103-il-17-producing-group-3-innate-lymphoid-cells-represent-the-dominant-lymphocyte-subset-in-human-amniotic-fluid
#15
Nicole Marquardt, Martin A Ivarsson, Erik Sundström, Elisabet Åkesson, Elisa Martini, Liv Eidsmo, Jenny Mjösberg, Danielle Friberg, Marius Kublickas, Sverker Ek, Gunilla Tegerstedt, Åke Seiger, Magnus Westgren, Jakob Michaëlsson
Amniotic fluid (AF) surrounds the growing fetus, and cells derived from AF are commonly used for diagnosis of genetic diseases. Intra-amniotic infections are strongly linked to preterm birth, which is the leading cause of perinatal mortality worldwide. Surprisingly little is known, however, about mature hematopoietic cells in AF, which could potentially be involved in immune responses during pregnancy. In this study, we show that the dominating population of viable CD45(+) cells in AF is represented by a subset of fetal CD103(+) group 3 innate lymphoid cells (ILCs) producing high levels of IL-17 and TNF...
September 2, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27580709/development-of-somatosensory-evoked-potentials-in-foetal-sheep-effects-of-betamethasone
#16
P Anegroaie, M G Frasch, S Rupprecht, I Antonow-Schlorke, T Müller, H Schubert, O W Witte, M Schwab
AIM: Antenatal glucocorticoids are used to accelerate foetal lung maturation in babies threatened with premature labour. We examined the influence of glucocorticoids on functional and structural maturation of the central somatosensory pathway in foetal sheep. Somatosensory-evoked potentials (SEP) reflect processing of somatosensory stimuli. SEP latencies are determined by afferent stimuli transmission while SEP amplitudes reveal cerebral processing. METHODS: After chronic instrumentation of foetal sheep, mothers received saline (n = 9) or three courses of betamethasone (human equivalent dose of 2 × 110 μg kg(-1) betamethasone i...
September 1, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27531015/prenatal-dexamethasone-exposure-programs-the-development-of-the-pancreas-and-the-secretion-of-insulin-in-rats
#17
Yu-Chieh Chen, Ying-Hua Huang, Jiunn-Ming Sheen, You-Lin Tain, Hong-Ren Yu, Chih-Cheng Chen, Miao-Meng Tiao, Ho-Chang Kuo, Li-Tung Huang
BACKGROUND: There is increasing epidemiological evidence indicating that many chronic diseases originate during early life, even before birth, through what are termed fetal programming effects. Prenatal glucocorticoid is frequently used clinically to accelerate the maturation of the lung, but its long-term effects remain unclear. METHODS: We gave pregnant Sprague-Dawley rats either intraperitoneal dexamethasone (0.1 mg/kg body weight) or vehicle at Gestational Days 14-20 and assessed the effects to pancreas at Postnatal Days 7 and 120...
June 18, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27522653/bisphenol-a-suppresses-glucocorticoid-target-gene-enac%C3%AE-expression-via-a-novel-er%C3%AE-nf-%C3%AE%C2%BAb-gr-signalling-pathway-in-lung-epithelial-cells
#18
Ayten Hijazi, Haiyan Guan, Kaiping Yang
We previously demonstrated that prenatal exposure to Bisphenol A (BPA) disrupts fetal lung maturation likely through the glucocorticoid signalling pathway, but the precise molecular mechanisms remain obscure. Given that BPA diminished the expression of epithelial sodium channel-γ (ENaCγ), a well-known glucocorticoid receptor (GR) target gene, in fetal lungs, we used this GR target gene to delineate the molecular pathway through which BPA exerts its effects on lung cells. The A549 lung epithelial cell line was used as an in vitro model system...
August 13, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27518105/consequences-of-a-maternal-high-fat-diet-and-late-gestation-diabetes-on-the-developing-rat-lung
#19
Michelle L Baack, Benjamin J Forred, Tricia D Larsen, Danielle N Jensen, Angela L Wachal, Muhammad Ali Khan, Peter F Vitiello
RATIONALE: Infants born to diabetic or obese mothers are at risk of respiratory distress and persistent pulmonary hypertension of the newborn (PPHN), conceivably through fuel-mediated pathogenic mechanisms. Prior research and preventative measures focus on controlling maternal hyperglycemia, but growing evidence suggests a role for additional circulating fuels including lipids. Little is known about the individual or additive effects of a maternal high-fat diet on fetal lung development...
2016: PloS One
https://www.readbyqxmd.com/read/27514074/congenital-diaphragmatic-hernia-endotracheal-fluid-phospholipidic-profile-following-tracheal-occlusion-in-an-experimental-model
#20
Gloria Pelizzo, Maria Chiara Mimmi, Jose Luis Peiro, Mario Marotta, Francesco Amoroso, Mario Fusillo, Veronica Carlini, Valeria Calcaterra
OBJECTIVE: To compare endotracheal fluid (EF) and amniotic fluid (AF) phospholipidic profile changes following tracheal occlusion (TO) in the congenital diaphragmatic hernia (CDH) fetal lamb model, in order to support the efficacy of TO on lung maturity. METHODS: A diaphragmatic defect was induced at 70 days' gestation, TO was carried out at day 102 and cesarean section at 136 days' gestation. EF and AF samples, collected at delivery, were evaluated using mass spectrometry (the analysis focused on palmitoyloleoyl-phosphatidylcholine [POPC, PC(18:1/16:0)], dipalmitoyl-phosphatidylcholine [DPPC, PC(16:0/16:0)] and sphingomyelins [SMs])...
August 11, 2016: Journal of Perinatal Medicine
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