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Matthew P Adams, Catherine J Collier, Sven Uthicke, Yan X Ow, Lucas Langlois, Katherine R O'Brien
When several models can describe a biological process, the equation that best fits the data is typically considered the best. However, models are most useful when they also possess biologically-meaningful parameters. In particular, model parameters should be stable, physically interpretable, and transferable to other contexts, e.g. for direct indication of system state, or usage in other model types. As an example of implementing these recommended requirements for model parameters, we evaluated twelve published empirical models for temperature-dependent tropical seagrass photosynthesis, based on two criteria: (1) goodness of fit, and (2) how easily biologically-meaningful parameters can be obtained...
January 4, 2017: Scientific Reports
Maximilian Klement, Jiyun Zheng, Chengcheng Liu, Heng-Liang Tan, Victor Vai Tak Wong, Andre Boon-Hwa Choo, Dong-Yup Lee, Dave Siak-Wei Ow
Antibody fragments have shown targeted specificity to their antigens, but only modest tissue retention times in vivo and in vitro. Multimerization has been used as a protein engineering tool to increase the number of binding units and thereby enhance the efficacy and retention time of antibody fragments. In this work, we explored the effects of valency using a series of self-assembling polypeptides based on the GCN4 leucine zipper multimerization domain fused to a single-chain variable fragment via an antibody upper hinge sequence...
February 10, 2017: Journal of Biotechnology
Matilde Romano, Emilia Lacaria, Lorella Battini, Michele Aragona, Cristina Bianchi, Giuseppe Penno, Stefano Del Prato, Alessandra Bertolotto
INTRODUCTION: The 2009 Institute of Medicine (IOM) guidelines define adequate gestational weight gain (GWG) in the attempt to prevent maternal and neonatal adverse outcomes. The aim of this study was to assess whether the IOM guidelines are met in pregnant women with different pre-gestational body mass index (BMI). METHODS: The study included 230 pregnant women recruited at the University Hospital of Pisa (Italy) at their screening visit (24-28 weeks of gestation) for gestational diabetes (GDM)...
2015: Gynecological Endocrinology
Ana Díez-Fernández, Mairena Sánchez-López, Roberto Gulías-González, Blanca Notario-Pacheco, Jorge Cañete García-Prieto, Natalia Arias-Palencia, Vicente Martínez-Vizcaíno
OBJECTIVE: Muscular fitness levels have been associated with cardiometabolic risk in children, although whether body weight acts as a confounder or as an intermediate variable in this relationship remains controversial. The aim of this study was to examine whether the association between muscular fitness and cardiometabolic risk factors is mediated by body mass index (BMI). DESIGN AND METHODS: Cross-sectional study using a sample of 1158 schoolchildren aged 8-11 years from the province of Cuenca, Spain...
2015: PloS One
Erhan Sari, Abdulkadir Tepeler, Emrah Yuruk, Berkan Resorlu, Tolga Akman, Murat Binbay, Abdullah Armagan, Ali Unsal, Ahmet Yaser Muslumanoglu
The aim of the study to compare outcomes of flexible ureterorenoscopy in patients with different body mass index (BMI) scores and to explore whether the BMI has an effect on outcomes of RIRS. Five hundred and two patients who underwent flexible URS in 3 centers between 2008 and 2012 for the management of single upper urinary tract calculi were retrospectively reviewed. Patients were categorized as normal weight BMI 18.5 to 24.99 kg/m(2), overweight 25 to 29.99 kg/m(2), obese 30 to 39.99 kg/m(2) and morbid obese >40 kg/m(2)...
November 2013: Urolithiasis
Danilo Sales Bocalini, Lucas S Lima, Socrates de Andrade, Angelo Madureira, Roberta L Rica, Rodrigo Nolasco Dos Santos, Andrey Jorge Serra, Jose Antonio Silva, Daniel Rodriguez, Aylton Figueira, Francisco Luciano Pontes
AIM: The aim of this study was to investigate the impact of circuit-based exercise on the body composition in obese older women by focusing on physical exercise and body weight (BW) gain control in older people. METHODS: Seventy older women (>60 years old) voluntarily took part in the study. Participants were randomized into six different groups according to body mass index (BMI): appropriate weight (AW) control (AWC) and trained (AWT) groups, overweight (OW) control (OWC) and trained (OWT) groups, and obesity (O) control (OC) and trained (OT) groups...
2012: Clinical Interventions in Aging
Paola Argiento, Rebecca R Vanderpool, Massimiliano Mulè, Maria Giovanna Russo, Michele D'Alto, Eduardo Bossone, Naomi C Chesler, Robert Naeije
BACKGROUND: Exercise stress echocardiography has not been recommended in the diagnostic workup of pulmonary hypertension because of insufficient certainty about feasibility and limits of normal. METHODS: Doppler echocardiography pulmonary hemodynamic measurements were performed at a progressively increased workload in 56 healthy male and 57 healthy female volunteers aged 19 to 63 years. Mean pulmonary artery pressure (mPAP) was estimated from the maximal tricuspid regurgitation jet velocity...
November 2012: Chest
A Page Glave, Jacilyn M Olson, Danika K Applegate, Ro Di Brezzo
The bodyweight squat is a common movement and is safe and effective. There are many variations and techniques, but little research has explored alterations of the movement. The purpose of this study was to examine the effects of 2 arm positions on select kinematic variables during the bodyweight squat. The participants were classified as normal-weight (NW: n = 17, height: 1.67 ± 0.06 m, weight: 61.25 ± 6.90 kg, body mass index [BMI]: 21.92 ± 1.68) or overweight (OW: n = 11, height: 1.68 ± 0.06 m, weight: 88...
November 2012: Journal of Strength and Conditioning Research
Joerg Doerfer, Thomas Meyer, Peter Klein, Nathaniel Melling, Alexander G Kerscher, Werner Hohenberger, Joerg Ow Pelz
INTRODUCTION: This study was designed to analyze whether routine radiological controls of anastomoses in the upper gastrointestinal tract an early detection of anastomotic leaks. PATIENTS AND METHODS: 135 patients who underwent upper gastrointestinal tract surgery were retrospectively analyzed. Patients in the first group (n = 55) underwent routine radiological control of the anastomoses. In the second group (n = 80) the radiological control was only performed in case of clinical symptoms or signs of anastomotic leaks...
2010: Patient Safety in Surgery
Ilaria Carpinella, Paolo Crenna, Marco Rabuffetti, Maurizio Ferrarin
Locomotion studies employ either treadmill (TW) or overground walking (OW), considering that differences between them are negligible. The present study tests this notion by comparing coordination between upper- and lower-limb movements in healthy individuals during OW and TW at matched speeds. Results indicated that TW induced a higher cadence, which highly influenced interlimb coordination, in terms of frequency coupling and relative phase between arm and thigh motion. At low speed, the 2:1 pattern (double arm swing per stride) displayed lower incidence in TW compared to OW, and this was correlated with a lower sagittal acceleration at the shoulders, at twice the stride frequency, in the former condition...
January 2010: European Journal of Applied Physiology
Aniceto Baltasar, Carlos Serra, Rafael Bou, Marcelo Bengochea, Nieves Pérez, Fernando Borrás, Picard Marceau
INTRODUCTION: The body mass index (BMI) is the most practical method to measure and compare obesity between individuals. The Percentage of Excess BMI Loss (PEBMIL) is used to present results in operated patients and is based on the premise that a BMI-25 is the final aim, on being the upper limit in normal subjects. It is possible to achieve a BMI-25 in morbid obese (MO) patients with initial low BMIs (<50) but it is rare in overweight (OW) patients with a BMI>50. Expected BMI (EBMI) would be that which should be reached by all subjects depending on their initial BMI...
November 2009: Cirugía Española
Lars M Blank, Georgios Ionidis, Birgitta E Ebert, Bruno Bühler, Andreas Schmid
A key limitation of whole-cell redox biocatalysis for the production of valuable, specifically functionalized products is substrate/product toxicity, which can potentially be overcome by using solvent-tolerant micro-organisms. To investigate the inter-relationship of solvent tolerance and energy-dependent biocatalysis, we established a model system for biocatalysis in the presence of toxic low logP(ow) solvents: recombinant solvent-tolerant Pseudomonas putida DOT-T1E catalyzing the stereospecific epoxidation of styrene in an aqueous/octanol two-liquid phase reaction medium...
October 2008: FEBS Journal
M Hooper, A Faustino, I R Reid, D Hosking, N L Gilchrist, P Selby, M Wu, G Salzmann, J West, A Leung
UNLABELLED: Daily oral tablet bisphosphonate therapy for Paget's disease of bone may cause serious upper gastrointestinal adverse events. A once-weekly alendronate 280 mg oral buffered solution was compared with an alendronate 40 mg/day tablet. While both were similarly effective, the tablet appeared to be better tolerated in this study. INTRODUCTION: Although daily doses of oral bisphosphonates are a generally safe and effective treatment for Paget's disease of bone (PDB), some patients may experience upper gastrointestinal adverse events (UGI AEs) or find the dosing requirements inconvenient and become noncompliant...
January 2009: Osteoporosis International
Lana M Widman, Richard Ted Abresch, Dennis M Styne, Craig M McDonald
OBJECTIVE: To determine whether the aerobic fitness, upper extremity strength, and body composition in groups of adolescents with mobility impairment due to thoracic and upper lumbar spinal cord injury (SCI) or spina bifida (SB) are significantly different from those in groups of adolescents without mobility impairment who are of normal weight (CTRL) or overweight (OW). SUBJECTS: One hundred fifteen total subjects were evaluated including 59 female (19 SB, 9 SCI, 17 OW, and 14 CTRL) and 56 male (18 SB, 10 SCI, 8 OW, and 20 CTRL) participants aged 11 to 21 years...
2007: Journal of Spinal Cord Medicine
Bruna Guida, Angelo Pietrobelli, Rossella Trio, Roberta Laccetti, Claudio Falconi, Nunzia Ruggiero Perrino, Silvestre Principato, Pierluigi Pecoraro
OBJECTIVE: To describe bioelectrical impedance vector distribution in relation to BMI (body mass index; body weight/stature(2)) in a population of healthy children in order to detect possible changes in body composition status. DESIGN: Observational study involving 464 healthy 8-year-old children. The subjects were divided into three groups based on their BMI: 218 normal weight (NW) children with BMI<18.4 for male and BMI<18.3 for female; 135 overweight (OW) children with BMI 18...
February 2008: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Jerry M Neff, Ståle Johnsen, Tone K Frost, Toril I Røe Utvik, Gregory S Durell
Large volumes of water often are produced with oil and gas from offshore platforms. The produced water is separated from the oil and gas and either reinjected into a deep formation or discharged to the ocean. The Norwegian oil and gas industry advocates ecological risk assessment as the basis for managing produced water discharges to the North Sea. In this paper, we compare estimates of ecological risks to water-column communities based on data on hydrocarbon residues in soft tissues of blue mussels deployed for a month near offshore platforms and based on predictions of the Dose related Risk and Effect Assessment Model (DREAM)...
September 2006: Marine Environmental Research
Władimir Boziłow, Witold Malinowski, Zbigniew Klempous, Sławomir Jeka
Fetus in fetu is a very rare abnormality (estimated incidences: 1 in 500,000 deliveries), and is secondary to a pathological diamniotic monochorionic pregnancy. It consists of a malformed parasitic twin that is found within the body of its sibling. Hardly 70 cases have been reported in the literature since its first description about 1800. Its discovery is usually postnatal. We present two boys: two and half years and eleven days old newborn presented a mass in the retroperitoneum in the left upper abdominal quadrant...
March 2005: Ginekologia Polska
Anthony I Sebba, Sydney Lou Bonnick, Risa Kagan, Desmond E Thompson, Carol S Skalky, Erluo Chen, Anne E de Papp
OBJECTIVE: The FACT study (Fosamax Actonel Comparison Trial) was a 1-year-head-to-head trial comparing the efficacy and tolerability of once weekly (DW) alendronate 70 mg and OW risedronate 35 mg for the treatment of postmenopausal osteoporosis. The present analysis was performed to determine the percentage of patients who had changes during the study in BMD and biochemical markers (BCMs) of bone turnover above or below specific cut-off points. A subgroup analysis of upper gastrointestinal (UGI) tolerability was also performed...
December 2004: Current Medical Research and Opinion
Urszula Ciesielska, Piotr Dziegiel, Ewa Jagoda, Marzena Podhorska-Okołów, Maciej Zabel
Helicobacter pylori is thought to represent a significant etiopathogenic factor in diseases of the upper gastrointestinal tract. It seems, therefore, important to elaborate effective techniques for its detection. The aim of the present study was to evaluate the effectiveness of Helicobacter pylori detection using the PCR technique on paraffin sections with various pairs of primers and to compare the results with those of a histological appraisal. Material for the studies involved 50 paraffin blocks with gastric mucosa biopsies fixed in 4% buffered formalin...
May 2004: Folia Morphologica (Warsz)
David Hosking, Silvano Adami, Dieter Felsenberg, Jorge Cannata Andia, Matti Välimäki, Laurent Benhamou, Jean-Yves Reginster, Carol Yacik, Andrea Rybak-Feglin, Richard A Petruschke, Luna Zaru, Arthur C Santora
OBJECTIVE: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis. RESEARCH DESIGN AND METHODS: This was a 3-month, randomised, double-blind, placebo-controlled study with a double-blind extension to 12 months. The study enrolled 549 postmenopausal women (ALN 219, RIS 222 and placebo (PBO) 108) who were > or =60 years of age at outpatient centres...
2003: Current Medical Research and Opinion
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