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https://www.readbyqxmd.com/read/27890535/partial-hepatectomy-hemodynamics-changes-experimental-data-explained-by-closed-loop-lumped-modeling
#1
Chloe Audebert, Mohamed Bekheit, Petru Bucur, Eric Vibert, Irene E Vignon-Clementel
The liver function may be degraded after partial liver ablation surgery. Adverse liver hemodynamics have been shown to be associated to liver failure. The link between these hemodynamics changes and ablation size is however poorly understood. This article proposes to explain with a closed-loop lumped model the hemodynamics changes observed during twelve surgeries in pigs. The portal venous tree is modeled with a pressure-dependent variable resistor. The variables measured, before liver ablation, are used to tune the model parameters...
November 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27677712/personalized-treatment-of-patients-with-very-early-hepatocellular-carcinoma
#2
Alessandro Vitale, Markus Peck-Radosavljevic, Edoardo G Giannini, Eric Vibert, Wolfgang Sieghart, Sven Van Poucke, Timothy M Pawlik
Hepatocellular carcinoma (HCC), in its very early stage, is heterogeneous both in terms of liver function (i.e. presence or absence of portal hypertension, Model for End stage Liver Disease score, Child Pugh score 5 or 6, bilirubin level) and tumour characteristics (i.e. location, alpha-fetoprotein values, pathological features such as micro-vascular invasion, tumour grade and satellitosis). Existing evidence in comparing different curative options for patients with very early HCC is poor due to small sample sizes and lack of solid subgroup analyses...
September 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27125753/early-recurrence-after-hepatectomy-for-colorectal-liver-metastases-what-optimal-definition-and-what-predictive-factors
#3
Katsunori Imai, Marc-Antoine Allard, Carlos Castro Benitez, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
BACKGROUND: The purpose of this study was to determine the optimal definition and elucidate the predictive factors of early recurrence after surgery for colorectal liver metastases (CRLM). METHODS: Among 987 patients who underwent curative surgery for CRLM from 1990 to 2012, 846 with a minimum follow-up period of 24 months were eligible for this study. The minimum p value approach of survival after initial recurrence was used to determine the optimal cutoff for the definition of early recurrence...
July 2016: Oncologist
https://www.readbyqxmd.com/read/27097277/intention-to-treat-analysis-of-percutaneous-endovascular-treatment-of-hepatic-artery-stenosis-after-orthotopic-liver-transplantation
#4
Muthukumarassamy Rajakannu, Sameh Awad, Oriana Ciacio, Gabriella Pittau, René Adam, Antonio Sa Cunha, Denis Castaing, Didier Samuel, Maïté Lewin, Daniel Cherqui, Eric Vibert
Hepatic artery stenosis (HAS) is a rare complication of orthotopic liver transplantation (LT). HAS could evolve into complete thrombosis and lead to graft loss, incurring significant morbidity and mortality. Even though endovascular management by percutaneous transluminal angioplasty ± stenting (PTA) is the primary treatment of HAS, its longterm impact on hepatic artery (HA) patency and graft survival remains unclear. This study aimed to evaluate longterm outcomes of PTA and to define the risk factors of treatment failure...
July 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26943031/evidence-of-intermetastatic-heterogeneity-for-pathological-response-and-genetic-mutations-within-colorectal-liver-metastases-following-preoperative-chemotherapy
#5
Mylène Sebagh, Marc-Antoine Allard, Nelly Bosselut, Myriam Dao, Eric Vibert, Maïté Lewin, Antoinette Lemoine, Daniel Cherqui, René Adam, Antonio Sa Cunha
BACKGROUND: In patients receiving preoperative chemotherapy, colorectal liver metastases (CLM) are expected to demonstrate a similar behaviour because of similar organ microenvironment and tumour cell chemosensitivity. We focused on the occurrence of pathological and genetic heterogeneity within CLM. METHODS: Patients resected for multiple CLM between 2004 and 2011 after > three cycles of chemotherapy were included. Pathological heterogeneity was arbitrarily defined as a > 50% difference in the percentage of remaining tumour cells between individual CLM...
April 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26919265/liver-transplantation-for-adenomatosis-european-experience
#6
Laurence Chiche, Anaelle David, René Adam, M Martin Oliverius, Jürgen Klempnauer, Eric Vibert, Michele Colledan, Jan Lerut, V Vincenzo Mazzafero, Stefano Di-Sandro, Christophe Laurent, Vincenzo Scuderi, Bertrand Suc, Roberto Troisi, Phillipe Bachelier, Jerôme Dumortier, Jean Gugenheim, Jean-Yves Mabrut, Ignacio Gonzalez-Pinto, François-René Pruvot, Yves Patrice Le-Treut, Francis Navarro, Jorge Ortiz-de-Urbina, Ephrem Salamé, Marco Spada, Paulette Bioulac-Sage
The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded...
April 2016: Liver Transplantation
https://www.readbyqxmd.com/read/26902140/serial-volumetric-assessment-of-large-for-size-liver-grafts-after-whole-cadaveric-liver-transplant-in-adults-do-large-liver-grafts-shrink-in-size
#7
Mohamed Bekheit, Muthukumarassamy Rajakannu, Petru Bucur, Rene Adam, Antonio SaCunha, Denis Castaing, Daniel Cherqui, Eric Vibert
BACKGROUND: After whole graft orthotopic liver transplantation (OLT), adaptation of the large grafts' volume to recipient weight is widely accepted despite the paucity of evidence on this subject. METHODS: Thirty nine patients with GRWR > 2.5% were included in this study and subsequently divided into two groups with 3 ≥ GRWR > 3%. Patients had CT scans at three predetermined time points after OLT used for measuring the liver volume. The objective of this study is to evaluate the volumetric changes of whole large liver grafts after adult OLT...
February 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26822881/long-term-survival-benefit-and-potential-for-cure-after-r1-resection-for-colorectal-liver-metastases
#8
Isamu Hosokawa, Marc-Antoine Allard, Maximiliano Gelli, Oriana Ciacio, Eric Vibert, Daniel Cherqui, Antonio Sa Cunha, Denis Castaing, Masaru Miyazaki, René Adam
BACKGROUND: Although efficient chemotherapy regimens have improved outcomes after R1 resection (positive margins) for colorectal liver metastases (CLMs), the long-term survival benefit and potential for cure after R1 resection have not been clearly demonstrated. The aim of this study was to evaluate the long-term outcome after R1 resection for CLM, and to identify factors predictive of cure. METHODS: All resected CLM patients at our institution from 2000 to 2009 were prospectively evaluated...
June 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26780428/repeat-liver-retransplantation-rationale-and-outcomes
#9
Riccardo Memeo, Andrea Laurenzi, Gabriella Pittau, Santiago Sanchez-Cabus, Eric Vibert, Rene Adam, Daniel Azoulay, Antonio Sa Cunha, Philippe Ichai, Faouzi Saliba, Didier Samuel, Daniel Cherqui, Denis Castaing
BACKGROUND: Liver retransplantation remains the only option for recurrent graft failure. The aim of our study is to identify predictive factors involved in patients and graft survival for patients undergoing repeat retransplantation (RRT). METHODOLOGY: From January 1985 to December 2012, 2940 liver transplantations were performed in 2477 patients at Paul Brousse Hospital, Villejuif, France. All patients who underwent third, fourth, and fifth transplantation were included in the study and retrospectively analyzed...
March 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26649581/salvage-versus-primary-liver-transplantation-for-early-hepatocellular-carcinoma-do-both-strategies-yield-similar-outcomes
#10
Prashant Bhangui, Marc Antoine Allard, Eric Vibert, Daniel Cherqui, Gilles Pelletier, Antonio Sa Cunha, Catherine Guettier, Jean-Charles Duclos Vallee, Faouzi Saliba, Henri Bismuth, Didier Samuel, Denis Castaing, René Adam
BACKGROUND DATA: In compensated cirrhotics with early hepatocellular carcinoma (HCC-cirr), upfront liver resection (LR) and salvage liver transplantation (SLT) in case of recurrence may have outcomes comparable to primary LT (PLT). OBJECTIVE: An intention-to-treat (ITT) analysis comparing PLT and SLT strategies. METHODS: Of 130 HCC-cirr patients who underwent upfront LR (group LR), 90 (69%) recurred, 31 could undergo SLT (group SLT). During the same period, 366 patients were listed for LT (group LLT); 26 dropped-out (7...
July 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26583680/influence-of-depression-on-recovery-after-major-noncardiac-surgery-a-prospective-cohort-study
#11
MULTICENTER STUDY
Massimiliano Orri, Emmanuel Boleslawski, Jean Marc Regimbeau, Caroline Barry, Christine Hassler, Emilie Gregoire, Philippe Bachellier, Olivier Scatton, Jean Yves Mabrut, Mustapha Adham, Eric Vibert, Anne Revah-Levy, Olivier Farges
OBJECTIVES: To determine the influence of patient depression (and anxiety) on postoperative outcome and surgeons' consideration of it. BACKGROUND: Patients' mental state influences the course of nonpsychiatric diseases. Evidence in the surgical setting comes mainly from cardiac-surgery patients and no predictive-model of postoperative outcome considers this dimension. METHODS: This prospective multicenter study included patients undergoing liver resections, a model of major abdominal surgery, between September 2013 and September 2014 in 8 centers...
November 2015: Annals of Surgery
https://www.readbyqxmd.com/read/26583667/arterial-lactate-concentration-at-the-end-of-an-elective-hepatectomy-is-an-early-predictor-of-the-postoperative-course-and-a-potential-surrogate-of-intraoperative-events
#12
RANDOMIZED CONTROLLED TRIAL
Eric Vibert, Emmanuel Boleslawski, Cyril Cosse, Rene Adam, Denis Castaing, Daniel Cherqui, Salima Naili, Jean-Marc Régimbeau, Antonio Sa Cunha, Stephanie Truant, Maher Fleyfel, François-René Pruvot, Catherine Paugam-Burtz, Olivier Farges
OBJECTIVES: To test the prognostic impact of arterial lactate concentration at the end-of-surgery (LCT-EOS) on postoperative outcome after elective liver-resections and to identify the predictors of an increase in LCT-EOS. BACKGROUND DATA: A recent systematic-review of risk-prediction-models for liver resections has evidenced their poor accuracy and a deficit in the evaluation of intraoperative events. LCT-EOS is a marker of impaired tissue oxygenation. METHODS: This prospectively-designed study was based on a training-cohort of 519 patients and a validation-cohort of 466 patients...
November 2015: Annals of Surgery
https://www.readbyqxmd.com/read/26583665/failure-to-achieve-a-2-stage-hepatectomy-for-colorectal-liver-metastases-how-to-prevent-it
#13
Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
OBJECTIVES: The aim of the study was to identify predictive factors of failure of 2-stage hepatectomy (TSH) for the selection of patients with extensive bilobar colorectal liver metastases (CRLM), who are candidates for TSH. BACKGROUND: The main weakness of TSH is the risk of failure to complete both the sequential procedures. METHODS: Between 2000 and 2012, from a total cohort of 845 patients resected for CRLM, 125 patients (14.8%) with extensive CRLM were planned for TSH...
November 2015: Annals of Surgery
https://www.readbyqxmd.com/read/25989502/spontaneous-splenorenal-shunt-in-liver-transplantation-results-of-left-renal-vein-ligation-versus-renoportal-anastomosis
#14
Nicolas Golse, Petru Octav Bucur, François Faitot, Mohamed Bekheit, Gabriella Pittau, Oriana Ciacio, Antonio Sa Cunha, René Adam, Denis Castaing, Didier Samuel, Daniel Cherqui, Eric Vibert
BACKGROUND: Management of portal inflow to the graft in patients with spontaneous splenorenal shunts (SRS) is a matter of concern especially in case of large varices (more than 1 cm). In case of portal vein (PV) thrombosis (PVT), renoportal anastomosis (RPA) directly diverts the splanchnic and renal venous blood assuring a good portal inflow to the graft. Disconnection of the portacaval shunt by left renal vein ligation (LRVL) is another option but requires a patent PV. The indication of primary RPA rather than LRVL in patients with small native PV, especially in case of large graft, should be questioned in these complex cases of liver transplantation...
December 2015: Transplantation
https://www.readbyqxmd.com/read/25914217/impact-of-clinically-evident-portal-hypertension-on-the-course-of-hepatocellular-carcinoma-in-patients-listed-for-liver-transplantation
#15
François Faitot, Marc-Antoine Allard, Gabriella Pittau, Oriana Ciacio, René Adam, Denis Castaing, Antonio Sa Cunha, Gilles Pelletier, Daniel Cherqui, Didier Samuel, Eric Vibert
UNLABELLED: Liver transplantation (LT) is the best curative treatment for early hepatocellular carcinoma (HCC) in patients with cirrhosis. However, the current shortage of organs causes prolonged waiting times and poorer intention-to-treat (ITT) survival (i.e., after listing) owing to tumor progression and dropout. Portal hypertension (PH) is a recognized risk factor of HCC development in patients with cirrhosis and its recurrence after resection. The aim of this study was to evaluate the potential impact of PHT on the results of LT on an ITT basis...
July 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/25865077/first-experience-of-liver-transplantation-with-type-2-donation-after-cardiac-death-in-france
#16
Eric Savier, Federica Dondero, Eric Vibert, Daniel Eyraud, Hélène Brisson, Bruno Riou, Fabienne Fieux, Salima Naili-Kortaia, Denis Castaing, Jean-Jacques Rouby, Olivier Langeron, Safi Dokmak, Laurent Hannoun, Jean-Christophe Vaillant
Organ donation after unexpected cardiac death [type 2 donation after cardiac death (DCD)] is currently authorized in France and has been since 2006. Following the Spanish experience, a national protocol was established to perform liver transplantation (LT) with type 2 DCD donors. After the declaration of death, abdominal normothermic oxygenated recirculation was used to perfuse and oxygenate the abdominal organs until harvesting and cold storage. Such grafts were proposed to consenting patients < 65 years old with liver cancer and without any hepatic insufficiency...
May 2015: Liver Transplantation
https://www.readbyqxmd.com/read/25856406/ischemic-postconditioning-of-the-liver-graft-in-adult-liver-transplantation
#17
Luana Ricca, Antoinette Lemoine, François Cauchy, Jocelyne Hamelin, Mylène Sebagh, Davide Degli Esposti, Chady Salloum, Eric Vibert, Genoveffa Balducci, Daniel Azoulay
BACKGROUND: Ischemia-reperfusion (I/R) injury is the main cause of graft failure in liver transplantation (LT). Ischemic postconditioning (IPo) has shown to be beneficial against I/R injury. Our objective was to compare the results of LT with or without IPo. METHODS: One hundred patients undergoing LT alternatively received IPo or not. At the time of arterial reperfusion, IPo consisted of three 1-minute arterial occlusions, interspersed with 1-minute reperfusion pauses...
August 2015: Transplantation
https://www.readbyqxmd.com/read/25646884/does-pathological-response-after-transarterial-chemoembolization-for-hepatocellular-carcinoma-in-cirrhotic-patients-with-cirrhosis-predict-outcome-after-liver-resection-or-transplantation
#18
Marc-Antoine Allard, Mylène Sebagh, Aldrick Ruiz, Catherine Guettier, Bernard Paule, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Didier Samuel, Henri Bismuth, Denis Castaing, René Adam
BACKGROUND & AIMS: To investigate the prognostic significance of pathologic response (PR) after transarterial chemoembolization (TACE) in cirrhotic patients resected or transplanted for hepatocellular carcinoma (HCC), and to identify predictors of complete pathologic response (CPR). METHODS: Between 1990 and 2010, 373 consecutive cirrhotic patients with HCC were treated by TACE followed by either liver resection (LR:184 patients) or liver transplantation (LT:189 patients)...
July 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25552233/donor-safety-in-live-donor-laparoscopic-liver-procurement-systematic-review-and-meta-analysis
#19
REVIEW
Mohamed Bekheit, Philipe-Abrahim Khafagy, Petru Bucur, Khaled Katri, Ahmed Elgendi, Wael Nabil Abdel-Salam, Eric Vibert, El-Said El-Kayal
BACKGROUND: Donor safety is a major concern in live organ donation. Live donor laparoscopic liver procurement is an advanced surgical procedure that is performed in highly specialized centers. Since its first report, not much progress has been endeavored for that procedure. METHODS: We planned to include all the randomized and comparative nonrandomized studies. Patients' population: live donors who are submitted to organ procurement via laparoscopy. RESULTS: Out of 5,636 records retrieved from the literature, only seven nonrandomized studies were included in this review, which encompassed 418 patients, 151 patients of whom underwent laparoscopic procurement...
November 2015: Surgical Endoscopy
https://www.readbyqxmd.com/read/25523036/interest-of-preoperative-immunonutrition-in-liver-resection-for-cancer-study-protocol-of-the-propils-trial-a-multicenter-randomized-controlled-phase-iv-trial
#20
RANDOMIZED CONTROLLED TRIAL
Oriana Ciacio, Thibault Voron, Gabriella Pittau, Maité Lewin, Eric Vibert, René Adam, Antonio Sa Cunha, Daniel Cherqui, Astrid Schielke, Olivier Soubrane, Olivier Scatton, Chady Salloum, Daniel Azoulay, Stéphane Benoist, Perrine Goyer, Jean-Christophe Vaillant, Laurent Hannoun, Emmanuel Boleslawski, Hélène Agostini, Didier Samuel, Denis Castaing
BACKGROUND: Malnutrition is an independent risk factor of postoperative morbidity and mortality and it's observed in 20 to 50% of surgical patients. Preoperative interventions to optimize the nutritional status, reduce postoperative complications and enteral nutrition has proven to be superior to the parenteral one. Moreover, regardless of the nutritional status of the patient, surgery impairs the immunological response, thus increasing the risk of postoperative sepsis. Immunonutrition has been developed to improve the immunometabolic host response in perioperative period and it has been proven to reduce significantly postoperative infectious complications and length of hospital stay in patients undergoing elective gastrointestinal surgery for tumors...
2014: BMC Cancer
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