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Eric vibert

Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
BACKGROUND AND OBJECTIVES: We aimed to define the cure rate in patients with colorectal liver metastases (CRLM) and concomitant extrahepatic disease (EHD) on the 5-year disease-free survival (DFS) after surgery, and identify the factors for predicting a cure. METHODS: Patients who underwent hepatectomy for CRLM with concomitant EHD were identified. Those followed for >5 years after surgery were enrolled. A cure was defined as DFS of >5 years after the last curative surgery...
March 2017: Journal of Surgical Oncology
Marion Paolini, Laurence Poul, Audrey Darmon, Matthieu Germain, Agnès Pottier, Laurent Levy, Eric Vibert
Nanomedicines are mainly used as drug delivery systems; here we evaluate a new application - to inhibit a drug's metabolism thereby enhancing its effective dose. Micelles containing the natural furanocoumarin 6',7'-dihydroxybergamottin (DHB), a known CYP450 inhibitor, were developed to transiently block hepatic CYP450-mediated drug metabolism and increase the bioavailability of the oncology drug docetaxel. Administered in mice 24h prior to the drug, DHB-micelles enhanced antitumor efficacy in the tumor xenograft models HT-29 and MDA-MB-231, when compared to the drug alone...
March 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Elena Fernandez-Sevilla, Marc-Antoine Allard, Jasmijn Selten, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, René Adam
Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role of surgery is uncertain in this case. The purpose of this study was to identify the prognostic factors of survival after post-LT HCC recurrence and to evaluate the impact of surgery in this setting. All patients transplanted for HCC between 1991 and 2013 in a single institution and who further developed a post-LT recurrence were included in this study. Univariate and multivariate analyses were performed to identify factors affecting postrecurrence survival...
April 2017: Liver Transplantation
Petru O Bucur, Mohamed Bekheit, Chloe Audebert, Amnah Othman, Seddik Hammad, Mylene Sebagh, Marc-Antoine Allard, Benoît Decante, Adrian Friebel, Elodie Miquelestorena-Standley, Dirk Drasdo, Jan G Hengstler, Irene E Vignon-Clementel, Eric Vibert
OBJECTIVE: To investigate safety and efficacy of temporary portal hemodynamics modulation with a novel percutaneously adjustable vascular ring (MID-AVR) onto a porcine model of 75% hepatectomy. BACKGROUND: Postoperative liver failure is a leading cause of mortality after major hepatectomy. Portal flow modulation is an increasingly accepted concept to prevent postoperative liver failure. Nonetheless, the current strategies have shortcomings. METHODS: Resection was performed under hemodynamic monitoring in 17 large, white pigs allocated into 2 groups...
February 1, 2017: Annals of Surgery
Nicolas Golse, Petru Octav Bucur, Oriana Ciacio, Gabriella Pittau, Antonio Sa Cunha, René Adam, Denis Castaing, Teresa Antonini, Audrey Coilly, Didier Samuel, Daniel Cherqui, Eric Vibert
Although sarcopenia is a common complication of cirrhosis, its diagnosis remains nonconsensual: computed tomography (CT) scan determinations vary and no cutoff values have been established in cirrhotic populations undergoing liver transplantation (LT). Our aim was to compare the accuracy of the most widely used measurement techniques and to establish useful cutoffs in the setting of LT. From the 440 patients transplanted between January 2008 and May 2011 in our tertiary center, we selected 256 patients with cirrhosis for whom a recent CT scan was available during the 4 months prior to LT...
February 2017: Liver Transplantation
Marc-Antoine Allard, Gaëlle Baillié, Carlos Castro-Benitez, Matthieu Faron, Frédérique Blandin, Daniel Cherqui, Denis Castaing, Antonio Sa Cunha, René Adam, Éric Vibert
BACKGROUND: The performance of linear models predicting Total Liver Weight (TLW) remains moderate. The use of more complex models such as Artificial Neural Network (ANN) and Generalized Additive Model (GAM) or including the variable "steatosis" may improve TLW prediction. This study aimed to assess the value of ANN and GAM and the influence of steatosis for predicting TLW. METHODS: Basic clinical and morphological variables of 1560 cadaveric donors for liver transplantation were randomly split into a training (2/3) and validation set (1/3)...
December 30, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Petru Bucur, Mohamed Bekheit, Chloe Audebert, Irene Vignon-Clementel, Eric Vibert
BACKGROUND: Accurate measuring of the hepatic hemodynamic parameters in humans is inconvenient. Swine has been a favorite surgical model for the study of liver conditions due to many similarities with human livers. However, pigs cannot tolerate pedicle clamping and to reduce bleeding during resection a simplified technique is required. The aim of this study is to present a simplified technique for different percentages of hepatic resection in a porcine model. METHODS: Twenty-two consecutive large white pigs were operated with 75% and 90% liver resection...
September 30, 2016: Journal of Surgical Research
Chloe Audebert, Mohamed Bekheit, Petru Bucur, Eric Vibert, Irene E Vignon-Clementel
The liver function may be degraded after partial liver ablation surgery. Adverse liver hemodynamics have been shown to be associated to liver failure. The link between these hemodynamics changes and ablation size is however poorly understood. This article proposes to explain with a closed-loop lumped model the hemodynamics changes observed during twelve surgeries in pigs. The portal venous tree is modeled with a pressure-dependent variable resistor. The variables measured, before liver ablation, are used to tune the model parameters...
January 4, 2017: Journal of Biomechanics
Alessandro Vitale, Markus Peck-Radosavljevic, Edoardo G Giannini, Eric Vibert, Wolfgang Sieghart, Sven Van Poucke, Timothy M Pawlik
Hepatocellular carcinoma (HCC), in its very early stage, is heterogeneous both in terms of liver function (i.e., presence or absence of portal hypertension, model for end-stage liver disease score, Child-Pugh score 5 or 6, bilirubin level) and tumor characteristics (i.e., location, alpha-fetoprotein values, pathological features such as microvascular invasion, tumor grade and satellitosis). Existing evidence in comparing different curative options for patients with very early HCC is poor due to small sample sizes and lack of solid subgroup analyses...
February 2017: Journal of Hepatology
Katsunori Imai, Marc-Antoine Allard, Carlos Castro Benitez, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
BACKGROUND: The purpose of this study was to determine the optimal definition and elucidate the predictive factors of early recurrence after surgery for colorectal liver metastases (CRLM). METHODS: Among 987 patients who underwent curative surgery for CRLM from 1990 to 2012, 846 with a minimum follow-up period of 24 months were eligible for this study. The minimum p value approach of survival after initial recurrence was used to determine the optimal cutoff for the definition of early recurrence...
July 2016: Oncologist
Muthukumarassamy Rajakannu, Sameh Awad, Oriana Ciacio, Gabriella Pittau, René Adam, Antonio Sa Cunha, Denis Castaing, Didier Samuel, Maïté Lewin, Daniel Cherqui, Eric Vibert
Hepatic artery stenosis (HAS) is a rare complication of orthotopic liver transplantation (LT). HAS could evolve into complete thrombosis and lead to graft loss, incurring significant morbidity and mortality. Even though endovascular management by percutaneous transluminal angioplasty ± stenting (PTA) is the primary treatment of HAS, its longterm impact on hepatic artery (HA) patency and graft survival remains unclear. This study aimed to evaluate longterm outcomes of PTA and to define the risk factors of treatment failure...
July 2016: Liver Transplantation
Mylène Sebagh, Marc-Antoine Allard, Nelly Bosselut, Myriam Dao, Eric Vibert, Maïté Lewin, Antoinette Lemoine, Daniel Cherqui, René Adam, Antonio Sa Cunha
BACKGROUND: In patients receiving preoperative chemotherapy, colorectal liver metastases (CLM) are expected to demonstrate a similar behaviour because of similar organ microenvironment and tumour cell chemosensitivity. We focused on the occurrence of pathological and genetic heterogeneity within CLM. METHODS: Patients resected for multiple CLM between 2004 and 2011 after > three cycles of chemotherapy were included. Pathological heterogeneity was arbitrarily defined as a > 50% difference in the percentage of remaining tumour cells between individual CLM...
April 19, 2016: Oncotarget
Laurence Chiche, Anaelle David, René Adam, M Martin Oliverius, Jürgen Klempnauer, Eric Vibert, Michele Colledan, Jan Lerut, V Vincenzo Mazzafero, Stefano Di-Sandro, Christophe Laurent, Vincenzo Scuderi, Bertrand Suc, Roberto Troisi, Phillipe Bachelier, Jerôme Dumortier, Jean Gugenheim, Jean-Yves Mabrut, Ignacio Gonzalez-Pinto, François-René Pruvot, Yves Patrice Le-Treut, Francis Navarro, Jorge Ortiz-de-Urbina, Ephrem Salamé, Marco Spada, Paulette Bioulac-Sage
The aim of this study was to collect data from patients who underwent liver transplantation (LT) for adenomatosis; to analyze the symptoms, the characteristics of the disease, and the recipient outcomes; and to better define the role of LT in this rare indication. This retrospective multicenter study, based on data from the European Liver Transplant Registry, encompassed patients who underwent LT for adenomatosis between January 1, 1986, and July 15, 2013, in Europe. Patients with glycogen storage disease (GSD) type IA were not excluded...
April 2016: Liver Transplantation
Mohamed Bekheit, Muthukumarassamy Rajakannu, Petru Bucur, Rene Adam, Antonio SaCunha, Denis Castaing, Daniel Cherqui, Eric Vibert
BACKGROUND: After whole graft orthotopic liver transplantation (OLT), adaptation of the large grafts' volume to recipient weight is widely accepted despite the paucity of evidence on this subject. METHODS: Thirty nine patients with GRWR > 2.5% were included in this study and subsequently divided into two groups with 3 ≥ GRWR > 3%. Patients had CT scans at three predetermined time points after OLT used for measuring the liver volume. The objective of this study is to evaluate the volumetric changes of whole large liver grafts after adult OLT...
February 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Isamu Hosokawa, Marc-Antoine Allard, Maximiliano Gelli, Oriana Ciacio, Eric Vibert, Daniel Cherqui, Antonio Sa Cunha, Denis Castaing, Masaru Miyazaki, René Adam
BACKGROUND: Although efficient chemotherapy regimens have improved outcomes after R1 resection (positive margins) for colorectal liver metastases (CLMs), the long-term survival benefit and potential for cure after R1 resection have not been clearly demonstrated. The aim of this study was to evaluate the long-term outcome after R1 resection for CLM, and to identify factors predictive of cure. METHODS: All resected CLM patients at our institution from 2000 to 2009 were prospectively evaluated...
June 2016: Annals of Surgical Oncology
Riccardo Memeo, Andrea Laurenzi, Gabriella Pittau, Santiago Sanchez-Cabus, Eric Vibert, Rene Adam, Daniel Azoulay, Antonio Sa Cunha, Philippe Ichai, Faouzi Saliba, Didier Samuel, Daniel Cherqui, Denis Castaing
BACKGROUND: Liver retransplantation remains the only option for recurrent graft failure. The aim of our study is to identify predictive factors involved in patients and graft survival for patients undergoing repeat retransplantation (RRT). METHODOLOGY: From January 1985 to December 2012, 2940 liver transplantations were performed in 2477 patients at Paul Brousse Hospital, Villejuif, France. All patients who underwent third, fourth, and fifth transplantation were included in the study and retrospectively analyzed...
March 2016: Clinical Transplantation
Prashant Bhangui, Marc Antoine Allard, Eric Vibert, Daniel Cherqui, Gilles Pelletier, Antonio Sa Cunha, Catherine Guettier, Jean-Charles Duclos Vallee, Faouzi Saliba, Henri Bismuth, Didier Samuel, Denis Castaing, René Adam
BACKGROUND DATA: In compensated cirrhotics with early hepatocellular carcinoma (HCC-cirr), upfront liver resection (LR) and salvage liver transplantation (SLT) in case of recurrence may have outcomes comparable to primary LT (PLT). OBJECTIVE: An intention-to-treat (ITT) analysis comparing PLT and SLT strategies. METHODS: Of 130 HCC-cirr patients who underwent upfront LR (group LR), 90 (69%) recurred, 31 could undergo SLT (group SLT). During the same period, 366 patients were listed for LT (group LLT); 26 dropped-out (7...
July 2016: Annals of Surgery
Massimiliano Orri, Emmanuel Boleslawski, Jean Marc Regimbeau, Caroline Barry, Christine Hassler, Emilie Gregoire, Philippe Bachellier, Olivier Scatton, Jean Yves Mabrut, Mustapha Adham, Eric Vibert, Anne Revah-Levy, Olivier Farges
OBJECTIVES: To determine the influence of patient depression (and anxiety) on postoperative outcome and surgeons' consideration of it. BACKGROUND: Patients' mental state influences the course of nonpsychiatric diseases. Evidence in the surgical setting comes mainly from cardiac-surgery patients and no predictive-model of postoperative outcome considers this dimension. METHODS: This prospective multicenter study included patients undergoing liver resections, a model of major abdominal surgery, between September 2013 and September 2014 in 8 centers...
November 2015: Annals of Surgery
Eric Vibert, Emmanuel Boleslawski, Cyril Cosse, Rene Adam, Denis Castaing, Daniel Cherqui, Salima Naili, Jean-Marc Régimbeau, Antonio Sa Cunha, Stephanie Truant, Maher Fleyfel, François-René Pruvot, Catherine Paugam-Burtz, Olivier Farges
OBJECTIVES: To test the prognostic impact of arterial lactate concentration at the end-of-surgery (LCT-EOS) on postoperative outcome after elective liver-resections and to identify the predictors of an increase in LCT-EOS. BACKGROUND DATA: A recent systematic-review of risk-prediction-models for liver resections has evidenced their poor accuracy and a deficit in the evaluation of intraoperative events. LCT-EOS is a marker of impaired tissue oxygenation. METHODS: This prospectively-designed study was based on a training-cohort of 519 patients and a validation-cohort of 466 patients...
November 2015: Annals of Surgery
Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
OBJECTIVES: The aim of the study was to identify predictive factors of failure of 2-stage hepatectomy (TSH) for the selection of patients with extensive bilobar colorectal liver metastases (CRLM), who are candidates for TSH. BACKGROUND: The main weakness of TSH is the risk of failure to complete both the sequential procedures. METHODS: Between 2000 and 2012, from a total cohort of 845 patients resected for CRLM, 125 patients (14.8%) with extensive CRLM were planned for TSH...
November 2015: Annals of Surgery
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