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JOURNAL ARTICLE
Annabel J Sorby-Adams, Oana C Marian, Isabella M Bilecki, Levi E Elms, Nawaf Yassi, Rebecca J Hood, Janet K Coller, Shannon M Stuckey, W Taylor Kimberly, Tracy D Farr, Anna V Leonard, Emma Thornton, Robert Vink, Renée J Turner
Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), with administration of an NK1-R antagonist shown to ameliorate BBB dysfunction and cerebral edema in rodent and permanent ovine stroke models. Given the importance of reperfusion in clinical stroke, this study examined the efficacy of NK1-R antagonist treatment in reducing cerebral edema and ICP in an ovine model of transient middle cerebral artery occlusion (tMCAo)...
March 28, 2024: Journal of Cerebral Blood Flow and Metabolism
#2
JOURNAL ARTICLE
Kym Wittholz, Amy J Bongetti, Kate Fetterplace, Marissa K Caldow, Amalia Karahalios, David P De Souza, Sheik Nadeem Elahee Doomun, Olav Rooyackers, René Koopman, Gordon S Lynch, Yasmine Ali Abdelhamid, Adam M Deane
BACKGROUND: During critical illness skeletal muscle wasting occurs rapidly. Although beta-hydroxy-beta-methylbutyrate (HMB) is a potential treatment to attenuate this process, the plasma appearance and muscle concentration is uncertain. METHODS: This was an exploratory study nested within a blinded, parallel group, randomized clinical trial in which critically ill patients after trauma received enteral HMB (3 g daily) or placebo. Plasma samples were collected at 0, 60, and 180 min after study supplement administration on day 1...
March 24, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
#3
JOURNAL ARTICLE
Kiran K Khush, James L Bernat, Richard N Pierson, Henry J Silverman, Brendan Parent, Alexandra K Glazier, Andrew B Adams, Jay A Fishman, Michael Gusmano, Wayne J Hawthorne, Mary E Homan, Daniel J Hurst, Stephen Latham, Chung-Gyu Park, Karen J Maschke, Muhammad M Mohiuddin, Robert A Montgomery, Jonah Odim, Rebecca D Pentz, Bruno Reichart, Julian Savulescu, Paul Root Wolpe, Renee P Wong, Kathleen N Fenton
Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival. However, many scientific questions remain regarding further requirements for genetic modification of donor organs, appropriate contexts for xenotransplantation research (including nonhuman primates, recently deceased humans, and living human recipients), and risk of xenozoonotic disease transmission...
March 19, 2024: American Journal of Transplantation
#4
JOURNAL ARTICLE
Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Gavin Brown, Rene Jackstadt, Colin Nixon, Kathryn Gilroy, Andrew Campbell, Owen J Sansom, David Y Lewis
PURPOSE: The current approach for molecular subtyping of colon cancer relies on gene expression profiling, which is invasive and has limited ability to reveal dynamics and spatial heterogeneity. Molecular imaging techniques, such as PET, present a noninvasive alternative for visualizing biological information from tumors. However, the factors influencing PET imaging phenotype, the suitable PET radiotracers for differentiating tumor subtypes, and the relationship between PET phenotypes and tumor genotype or gene expression-based subtyping remain unknown...
March 17, 2024: Clinical Cancer Research
#5
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Sonnet S Davis, Ray Lieh Yoon Low, Chi-Lu Chiu, Meng Fang, Fen Huang, Akhil Bhalla, Ceyda Llapashtica, Rachel Prorok, Michelle E Pizzo, Meredith E K Calvert, Elizabeth W Sun, Jennifer Hsiao-Nakamoto, Yashas Rajendra, Katrina W Lexa, Devendra B Srivastava, Bettina van Lengerich, Junhua Wang, Yaneth Robles-Colmenares, Do Jin Kim, Joseph Duque, Melina Lenser, Timothy K Earr, Hoang Nguyen, Roni Chau, Buyankhishig Tsogtbaatar, Ritesh Ravi, Lukas L Skuja, Hilda Solanoy, Howard J Rosen, Bradley F Boeve, Adam L Boxer, Hilary W Heuer, Mark S Dennis, Mihalis S Kariolis, Kathryn M Monroe, Laralynne Przybyla, Pascal E Sanchez, Rene Meisner, Dolores Diaz, Kirk R Henne, Ryan J Watts, Anastasia G Henry, Kannan Gunasekaran, Giuseppe Astarita, Jung H Suh, Joseph W Lewcock, Sarah L DeVos, Gilbert Di Paolo
No abstract text is available yet for this article.
March 14, 2024: Cell
#6
JOURNAL ARTICLE
Rachel C Wood, Angelique K Luabeya, Rane B Dragovich, Alaina M Olson, Katherine A Lochner, Kris M Weigel, Renée Codsi, Humphrey Mulenga, Margaretha de Vos, Mikashmi Kohli, Adam Penn-Nicholson, Mark Hatherill, Gerard A Cangelosi
UNLABELLED: Tongue dorsum swabbing is a potential alternative to sputum collection for tuberculosis (TB) testing. Previous studies showed that Cepheid Xpert MTB/RIF Ultra (Xpert Ultra) can detect Mycobacterium tuberculosis DNA on tongue swabs stored in buffer, with 72% sensitivity and 100% specificity relative to a sputum microbiological reference standard (sputum MRS). The present study evaluated a more convenient sample collection protocol (dry swab storage), combined with streamlined sample processing protocols, for evaluating two commercial TB diagnostic tests: Xpert Ultra and Molbio Truenat MTB Ultima (MTB Ultima)...
March 14, 2024: Journal of Clinical Microbiology
#7
JOURNAL ARTICLE
Muga Terasawa, Hiroshi Imamura, Marc Antoine Allard, Daniel Pietrasz, Oriana Ciacio, Gabriella Pittau, Chady Salloum, Antonio Sa Cunha, Daniel Cherqui, René Adam, Daniel Azoulay, Akio Saiura, Eric Vibert, Nicolas Golse
PURPOSE: In liver transplantation (LT) setting, to propose an innovative intraoperative criterion to judge arterial flow abnormality that may lead to early hepatic arterial occlusion, i.e. thrombosis or stenosis, when left untreated and to carry out re-anastomosis. PATIENTS AND METHODS: After liver graft implantation, and after ensuring that there is no abnormality on the Doppler ultrasound (qualitative and quantitative assessment), we intraoperatively injected indocyanine green dye (ICG, 0...
March 7, 2024: Liver Transplantation
#8
JOURNAL ARTICLE
Minna K Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J Neville, Natalie R van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O Mook-Kanamori, Ayse Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Christiana Kartsonaki, Liming Li, Kuang Lin, Fiona A Hagenbeek, Jouke Jan Hottenga, René Pool, M Arfan Ikram, Joyce van Meurs, Toomas Haller, Yuri Milaneschi, Mika Kähönen, Pashupati P Mishra, Peter K Joshi, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Ilhan E Acar, Carel B Hoyng, Yara T E Lechanteur, Lude Franke, Alexander Kurilshikov, Alexandra Zhernakova, Marian Beekman, Erik B van den Akker, Ivana Kolcic, Ozren Polasek, Igor Rudan, Christian Gieger, Melanie Waldenberger, Folkert W Asselbergs, Caroline Hayward, Jingyuan Fu, Anneke I den Hollander, Cristina Menni, Tim D Spector, James F Wilson, Terho Lehtimäki, Olli T Raitakari, Brenda W J H Penninx, Tonu Esko, Robin G Walters, J Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Ko Willems van Dijk, Fredrik Karpe, Mark I McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Markus Perola, Jaspal S Kooner, John C Chambers, Cornelia van Duijn, P Eline Slagboom, Dorret I Boomsma, John Danesh, Mika Ala-Korpela, Adam S Butterworth, Johannes Kettunen
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7 . This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11 . Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts...
March 6, 2024: Nature
#9
JOURNAL ARTICLE
Yulia Eygeris, Mohit Gupta, Jeonghwan Kim, Antony Jozic, Milan Gautam, Jonas Renner, Dylan Nelson, Elissa Bloom, Adam Tuttle, Jonathan Stoddard, Rene Reynaga, Martha Neuringer, Andreas K Lauer, Renee C Ryals, Gaurav Sahay
Lipid nanoparticles (LNPs) largely rely on ionizable lipids to yield successful nucleic acid delivery via electrostatic disruption of the endosomal membrane. Here, we report the identification and evaluation of ionizable lipids containing a thiophene moiety (Thio-lipids). The Thio-lipids can be readily synthesized via the Gewald reaction, allowing for modular lipid design with functional constituents at various positions of the thiophene ring. Through the rational design of ionizable lipid structure, we prepared 47 Thio-lipids and identified some structural criteria required in Thio-lipids for efficient mRNA (messenger RNA) encapsulation and delivery in vitro and in vivo...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
#10
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L Salisbury, Rachel E Geroux, Benjamin Gateno, Padraig J Flannery, Mrunal Dehankar, Cory C Funk, Jordan Wilkins, Anna Stepanova, Tara O'Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L Kirkland, Rachel A Kudgus, Renee A Schoon, Joel M Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K Lee, Eugenia Trushina
No abstract text is available yet for this article.
February 26, 2024: Communications Biology
#11
JOURNAL ARTICLE
Farid Rajabli, Azizi A Seixas, Bilcag Akgun, Larry D Adams, Jovita Inciute, Kara L Hamilton, Patrice G Whithead, Ioanna Konidari, Tianjie Gu, Jamie Arvizu, Charles G Golightly, Takiyah D Starks, Renee Laux, Goldie S Byrd, Jonathan L Haines, Gary W Beecham, Anthony J Griswold, Jeffery M Vance, Michael L Cuccaro, Margaret A Pericak-Vance
BACKGROUND: Cognitive and functional abilities in individuals with Alzheimer's disease (AD) pathology (ADP) are highly variable. Factors contributing to this variability are not well understood. Previous research indicates that higher educational attainment (EA) correlates with reduced cognitive impairments among those with ADP. While cognitive and functional impairments are correlated, they are distinguishable in their manifestations. OBJECTIVE: To investigate whether levels of education are associated with functional impairments among those with ADP...
February 19, 2024: Journal of Alzheimer's Disease: JAD
#12
JOURNAL ARTICLE
Corine E Post, Thom Bitter, Adam Briscoe, Inger van Langen, René Fluit, Nico Verdonschot, Dennis Janssen
Polyetheretherketone (PEEK) is of interest as implant material for cementless tibial total knee arthroplasty (TKA) components due to its potential advantages. One main advantage is that the stiffness of PEEK closely resembles the stiffness of bone, potentially avoiding peri-prosthetic stress-shielding. When introducing a new implant material for cementless TKA designs, it is essential to study its effect on the primary fixation. The primary fixation may be influenced by patient factors such as age, gender, and body mass index (BMI)...
January 25, 2024: Bioengineering
#13
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#14
JOURNAL ARTICLE
Farima Dalaei, Claire E E de Vries, Lotte Poulsen, Sören Möller, Manraj N Kaur, Phillip J Dijkhorst, Jørn Bo Thomsen, Maarten Hoogbergen, Dennis J S Makarawung, Aebele B Mink van der Molen, Jussi P Repo, Marek Adam Paul, Kay-Hendrik Busch, Annalisa Cogliandro, Jakub Opyrchal, Michael Rose, Claus B Juhl, Alin M Andries, Andreas Printzlau, René K Støving, Anne F Klassen, Andrea L Pusic, Jens A Sørensen
OBJECTIVE: To examine health-related quality of life (HRQL) and satisfaction with appearance in patients who have undergone bariatric surgery (BS) with or without subsequent body contouring surgery (BCS) in relation to the general population normative for the BODY-Q. BACKGROUND: The long-term impact of BS with or without BCS has not been established using rigorously developed and validated patient-reported outcome measures (PROM). The BODY-Q is a PROM developed to measure changes in HRQL and satisfaction with appearance in patients with BS and BCS...
February 20, 2024: Annals of Surgery
#15
JOURNAL ARTICLE
Edo Dongelmans, Nicole Erler, Rene Adam, Silvio Nadalin, Vincent Karam, Sezai Yilmaz, Claire Kelly, Jacques Pirenne, Koray Acarli, Michael Allison, Abdul Hakeem, Dhakshinamoorthy Vijayanand, Dzmitry Fedaruk, Oleg Rummo, Murat Kilic, Arno Nordin, Lutz Fischer, Alessandro Parente, Darius Mirza, William Bennet, Yaman Tokat, Francois Faitot, Barbara B Antonelli, Gabriela Berlakovich, David Patch, Frederik Berrevoet, Marija Ribnikar, Theophile Gerster, Eric Savier, Salvatore Gruttadauria, Bo-Göran Ericzon, Andrés Valdivieso, Valentin Cuervas-Mons, Baltasar Perez Saborido, Roland S Croner, Luciano De Carlis, Giulia Magini, Roberta Rossi, Irinel Popescu, Laze Razvan, Stefan Schneeberger, Hans Blokzijl, Laura Llado, Miguel Angel Gomez Bravo, Christophe Duvoux, Vladimír Mezjlík, Gabriel C Oniscu, Kelsey Pearson, Murat Dayangac, Valerio Lucidi, Olivier Detry, Fernando Rotellar, Caroline den Hoed, Wojciech G Polak, Sarwa Darwish Murad
BACKGROUND AND AIMS: Management of Budd-Chiari Syndrome (BCS) has improved over the last decades. The main aim was to evaluate the contemporary post-liver transplant (LT) outcomes in Europe. APPROACH AND RESULTS: Data from all transplanted patients from 1976-2020 was obtained from the European Liver Transplantation Registry (ELTR). Patients<16yrs, with secondary BCS or hepatocellular carcinoma were excluded. Patient- (PS) and graft survival (GS) before and after 2000 were compared...
February 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#16
JOURNAL ARTICLE
Alexis Robert, Lloyd A C Chapman, Rok Grah, Rene Niehus, Frank Sandmann, Bastian Prasse, Sebastian Funk, Adam J Kucharski
BACKGROUND: Recurring COVID-19 waves highlight the need for tools able to quantify transmission risk, and identify geographical areas at risk of outbreaks. Local outbreak risk depends on complex immunity patterns resulting from previous infections, vaccination, waning and immune escape, alongside other factors (population density, social contact patterns). Immunity patterns are spatially and demographically heterogeneous, and are challenging to capture in country-level forecast models...
February 14, 2024: BMC Infectious Diseases
#17
JOURNAL ARTICLE
Saif Bushnaq, Ameer E Hassan, Adam Delora, Ali Kerro, Anita Datta, Rime Ezzeldin, Zuhair Ali, Tunmi Anwoju, Layla Nejad, Rene Silva, Yazan Diya Abualnadi, Zorain Mustafa Khalil, Mohamad Ezzeldin
BACKGROUND AND PURPOSE: Automated CTP postprocessing packages have been developed for managing acute ischemic stroke. These packages use image processing techniques to identify the ischemic core and penumbra. This study aimed to investigate the agreement of decision-making rules and output derived from RapidAI and Viz.ai software packages in early and late time windows and to identify predictors of inadequate quality CTP studies. MATERIALS AND METHODS: One hundred twenty-nine patients with acute ischemic stroke who had CTP performed on presentation were analyzed by RapidAI and Viz...
April 4, 2024: AJNR. American Journal of Neuroradiology
#18
JOURNAL ARTICLE
James L Shepherdson, Katie Hutchison, Dilan Wellalage Don, George McGillivray, Tae-Ik Choi, Carolyn A Allan, David J Amor, Siddharth Banka, Donald G Basel, Laura D Buch, Deanna Alexis Carere, Renée Carroll, Jill Clayton-Smith, Ali Crawford, Morten Dunø, Laurence Faivre, Christopher P Gilfillan, Nina B Gold, Karen W Gripp, Emma Hobson, Alexander M Holtz, A Micheil Innes, Bertrand Isidor, Adam Jackson, Panagiotis Katsonis, Leila Amel Riazat Kesh, Sébastien Küry, François Lecoquierre, Paul Lockhart, Julien Maraval, Naomichi Matsumoto, Julie McCarrier, Josephine McCarthy, Noriko Miyake, Lip Hen Moey, Andrea H Németh, Elsebet Østergaard, Rushina Patel, Kate Pope, Jennifer E Posey, Rhonda E Schnur, Marie Shaw, Elliot Stolerman, Julie P Taylor, Erin Wadman, Emma Wakeling, Susan M White, Lawrence C Wong, James R Lupski, Olivier Lichtarge, Mark A Corbett, Jozef Gecz, Charles M Nicolet, Peggy J Farnham, Cheol-Hee Kim, Marwan Shinawi
Pathogenic variants in multiple genes on the X chromosome have been implicated in syndromic and non-syndromic intellectual disability disorders. ZFX on Xp22.11 encodes a transcription factor that has been linked to diverse processes including oncogenesis and development, but germline variants have not been characterized in association with disease. Here, we present clinical and molecular characterization of 18 individuals with germline ZFX variants. Exome or genome sequencing revealed 11 variants in 18 subjects (14 males and 4 females) from 16 unrelated families...
February 5, 2024: American Journal of Human Genetics
#19
JOURNAL ARTICLE
Amy Jayas, Ajit K Sachdeva, Keith A Delman, Adam S Kabaker, Patrice Gabler Blair, Renee Overton, Douglas Grbic, Dorothy A Andriole
OBJECTIVE: To determine the extent to which U.S. Liaison Committee of Medical Education (LCME)-accredited medical schools chose to participate in piloting a national curricular resource, the American College of Surgeons/Association of Program Directors in Surgery/Association of Surgical Education Resident Prep Curriculum ("ACS-surgery-prep curriculum"), and implications of such participation for student access nationally to this resource. DESIGN: We examined the significance of school-level differences in ACS-surgery-prep curriculum pilot participation and student-level differences in curriculum access based on medical school attended in bivariate analysis...
January 28, 2024: Journal of Surgical Education
#20
JOURNAL ARTICLE
Jonine Jancey, Renee N Carey, Becky Freeman, Tama Leaver, Katharina Wolf, Marilyn Bromberg, Kevin Chai, Stella Bialous, Phoebe Adams, Meghan Mcleod, Kahlia McCausland
INTRODUCTION: Mounting evidence suggests that electronic cigarettes (e-cigarettes) are extensively promoted and marketed using social media, including through user-generated content and social media influencers. This study explores how e-cigarettes are being promoted on Instagram, using a case-study approach, and the extent to which Meta's Restricted Goods and Services Policy (Meta's policy) is being applied and enforced. METHODS: We identified the accounts followed by an Australian Instagram influencer who primarily posts e-cigarette-related content...
2024: Tobacco Induced Diseases
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