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https://www.readbyqxmd.com/read/28437516/a-rare-case-of-misdiagnosed-silent-lung-cancer-with-solitary-metastasis-to-the-temporomandibular-joint-condyle
#1
Luca Guarda-Nardini, Edoardo Stellini, Adolfo Di Fiore, Daniele Manfredini
This article describes the case history of a 59-year-old female patient who sought advice for temporomandibular joint (TMJ) pain and sounds but who was actually diagnosed with a primary lung cancer with metastasis to the TMJ. The patient had a history of TMJ pain and deflection in jaw movement that progressively worsened over a few months and did not improve with the usual standard of care treatment provided by an orofacial pain practitioner. Magnetic resonance and computed tomography (CT) prescribed at a tertiary clinic showed an osteolytic bone mass within the right TMJ condyle...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28424735/tongue-necrosis-secondary-to-giant-cell-arteritis-a-case-report-and-literature-review
#2
Rafael Alex Barbosa de Siqueira Sobrinho, Karolina Cayres Alvino de Lima, Helena Carvalho Moura, Mônica Modesto Araújo, Christyanne Maria Rodrigues Barreto de Assis, Pedro Alves da Cruz Gouveia
Giant cell arteritis is a form of vasculitis involving the medium- and large-sized arteries that chiefly affects older people. Clinical findings are headache, jaw claudication, fever, pain, and thickening of the temporal artery. The most feared complication is visual loss due to impairment of the ophthalmic artery and posterior ciliary arteries. This a case report of an 85-year-old male presenting with headache and jaw pain, who was admitted with tongue necrosis as an initial manifestation of giant cell arteritis...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28420009/temporal-summation-and-motor-function-modulation-during-repeated-jaw-movements-in-patients-with-temporomandibular-disorder-pain-and-healthy-controls
#3
Yuanxiu Zhang, Sheng Shao, Jinglu Zhang, Lin Wang, Kelun Wang, Peter Svensson
Temporal summation of nociceptive inputs may be an important pathophysiological mechanism in temporomandibular disorders (TMD) pain; however, it remains unknown how natural jaw function relates to underlying pain mechanisms. This study evaluated changes in pain and movement patterns during repeated jaw movements in patients with painful temporomandibular joints (TMJ) compared with healthy controls. Twenty patients with TMD with TMJ pain, and an anterior disk displacement without reduction and 20 age- and gender-matched healthy volunteers were included...
March 31, 2017: Pain
https://www.readbyqxmd.com/read/28419379/central-sensitization-is-modulated-following-trigger-point-anesthetization-in-patients-with-chronic-pain-from-whiplash-trauma-a-double-blind-placebo-controlled-crossover-study
#4
N Ake Nystrom, Michael D Freeman
Objective. : Central sensitization (CS) with low peripheral pain thresholds (PPTs) is a common finding among patients with chronic pain after whiplash (CPWI). While it has been proposed that myofascial myofascial trigger points (MTrPs) may act as modulators of central sensitization, previously reported findings are conflicting and inconclusive. The present study was designed to investigate immediate responsiveness of CS to alterations in nociceptive input. Design.:  Controlled, double-blind, cross-over...
April 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28416991/can-denosumab-be-a-substitute-competitor-or-complement-to-bisphosphonates
#5
REVIEW
Su Young Kim, Hwoe Gyeong Ok, Christof Birkenmaier, Kyung Hoon Kim
Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from hematopoietic stem cells. When the RANKL binds to the RANK of the pre-osteoclasts or mature osteoclasts, bone resorption increases. On the contrary, when OPG binds to the RANK, bone resorption decreases. Denosumab (AMG 162), like OPG (a decoy receptor), binds to the RANKL, and reduces binding between the RANK and the RANKL resulting in inhibition of osteoclastogenesis and reduction of bone resorption...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28413598/solitary-peripheral-ivory-osteoma-of-the-mandible-presenting-with-difficulty-in-deglutition-a-case-report
#6
Kumar Nilesh, Aaditee V Vande, Suresh K Veerabhadrappa
Osteomas are benign bone tumors which arise from the cortex or medulla of craniofacial and jaw bones. They are usually asymptomatic or present as slow-growing painless masses. Larger lesions may present with aesthetic (facial asymmetry) and functional disturbances (jaw deviation, difficulty in breathing, pain, and sensory deficits). This paper highlights a case of solitary peripheral osteoma composed of a compact bony mass arising from the lower border of the mandible in an adult female patient. The lesion presented with discomfort during deglutition, which was attributed to impingement of muscles of the oral cavity floor, including the anterior belly of digastric muscle...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28412266/hyperparathyroidism-diagnosed-due-to-brown-tumors-of-the-jaw-a-case-report-and-literature-review
#7
Philip Brabyn, Ana Capote, Marko Belloti, Ian Zylberberg
This report describes the case of a 42-year-old woman who consulted with a maxillofacial specialist for pain and an exophytic lesion in the maxilla. Biopsy examination disclosed a bone cyst with abundant giant cells, and head and neck computed tomography was performed. A diagnosis of brown tumor in the maxilla and mandible was made, and primary hyperparathyroidism (parathyroid adenoma) was determined as the origin of the bone lesions. The patient underwent a left superior parathyroidectomy, which resolved the hormonal disorder (as determined by normal calcium and parathyroid hormone levels) and the brown tumors, which appeared to have mineralized at 1-year follow-up computed tomography...
March 20, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28412029/what-s-in-a-side-effect-the-association-between-pulmonary-vasodilator-adverse-drug-events-and-clinical-outcomes-in-patients-with-pulmonary-arterial-hypertension
#8
Peter J Leary, Suhyun Kang, Todd M Kolb, Bradley A Maron, David D Ralph, Youlan Rao, Ryan J Tedford, Roham T Zamanian
BACKGROUND: Adverse drug events (ADEs) with pulmonary vasodilator use in pulmonary arterial hypertension (PAH) are common. ADEs may contribute to worse quality of life; however, their relationship to prognosis is unknown. The objective of this study was to determine whether common ADEs after initiating subcutaneous treprostinil were associated with prognosis in PAH. METHODS: We assembled a retrospective cohort of participants from four clinical trials of treprostinil for PAH, including 908 participants who received subcutaneous treprostinil and 243 who received placebo at the time ADEs were ascertained...
April 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28410886/the-autogenous-graft-versus-transport-distraction-osteogenesis-for-reconstruction-of-the-ramus-condyle-unit-a-prospective-comparative-study
#9
S Kohli, S Mohanty, S Singh, Sandeep, J Dabas, R Patel
This study aimed to compare the joint function and morphology achieved following condylar reconstruction using sternoclavicular grafts (SCG) versus transport distraction osteogenesis (TDO) in temporomandibular joint (TMJ) ankylosis patients. Twenty-two patients with TMJ ankylosis underwent TMJ reconstruction with SCG or TDO (n=11 each). Radiographic and clinical evaluations were performed at 1 week and at 1, 3, and 6 months post-surgery. Clinical criteria examined included the duration of surgery, mean postoperative mouth opening, excursive jaw movements, and pain scores...
April 11, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28407268/cross-cultural-adaptation-reliability-and-construct-validity-of-the-tampa-scale-for-kinesiophobia-for-temporomandibular-disorders-tsk-tmd-br-into-brazilian-portuguese
#10
Aroldo Dos Santos Aguiar, Cesar Bataglion, Corine Mirjam Visscher, Debora Bevilaqua Grossi, Thais Cristina Chaves
BACKGROUND: Fear of movement (kinesiophobia) seems to play an important role in the development of chronic pain. However, in Temporomandibular Disorders (TMD) there is a scarcity of studies about this topic. The Tampa Scale for Kinesiophobia for TMD (TSK/TMD) is the most widely used instrument to measure fear of movement and it is not available in Brazilian Portuguese. OBJECTIVE: The purpose of this study was to culturally adapt the TSK/TMD to Brazilian Portuguese and to assess its psychometric properties regarding internal consistency, reliability, and construct and structural validity...
April 13, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28396234/intraoral-vacuum-assisted-closure-therapy-a-pilot-study-in-medication-related-osteonecrosis-of-the-jaw
#11
Johannes Laimer, Otto Steinmassl, Martin Hechenberger, Michael Rasse, Rajmond Pikula, Emanuel Bruckmoser
PURPOSE: For approximately 2 decades, vacuum-assisted closure (VAC) therapy has been widely used for the management of complex wounds and soft tissue defects on the external surface of the body. As yet, this technique has not been studied for intraoral wound management. Therefore, this study evaluated the feasibility, safety, and effectiveness of intraoral VAC therapy in patients with medication-related osteonecrosis of the jaw (MRONJ). PATIENTS AND METHODS: After successful construction of an intraoral device providing sufficient airtight sealing, individually manufactured appliances were used in a prospective clinical trial of 3 patients using the VAC therapy system...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28374968/long-term-functional-and-mobility-outcomes-for-individuals-with-arthrogryposis-multiplex-congenita
#12
Hirmand Nouraei, Bonita Sawatzky, Megan MacGillivray, Judith Hall
Arthrogryposis multiplex congenita (AMC) is a birth defect that involves congenital joint contractures in two or more joints including the limbs, spine, and jaw. The purpose of our study was to identify long-term outcomes of adults with AMC. We recruited 177 participants from over 15 countries, making this the largest international study of adults with AMC. Participants provided demographic information including living situation and mobility and completed two standardized outcome measures, of quality of life and physical activity, using an online survey format...
April 4, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28361003/case-report-primary-osteonecrosis-associated-with-thrombophilia-hypofibrinolysis-and-worsened-by-testosterone-therapy
#13
Michael Ian Jarman, Kevin Lee, Ariel Kanevsky, Sarah Min, Ilana Schlam, Chris Mahida, Ali Huda, Alexander Milgrom, Naila Goldenberg, Charles J Glueck, Ping Wang
BACKGROUND: Familial and acquired thrombophilia are often etiologic for idiopathic hip and jaw osteonecrosis (ON), and testosterone therapy (TT) can interact with thrombophilia, worsening ON. CASE PRESENTATION: Case 1: A 62-year-old Caucasian male (previous deep venous thrombosis), on warfarin 1 year for atrial fibrillation (AF), had non-specific right hip-abdominal pain for 2 years. CT scan revealed bilateral femoral head ON without collapse. Coagulation studies revealed Factor V Leiden (FVL) heterozygosity, 4G/4G plasminogen activator inhibitor (PAI) homozygosity, high anti-cardiolipin (ACLA) IgM antibodies, and endothelial nitric oxide (NO) synthase (eNOS) T786C homozygosity (reduced conversion of L-arginine to NO, required for bone health)...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28357005/peripheral-solitary-osteoma-of-the-zygomatic-arch-a-case-report-and-literature-review
#14
REVIEW
Thomas Starch-Jensen
Osteoma is a benign slow-growing osteogenic neoplasm commonly occurring in the craniofacial skeleton, characterized by the proliferation of compact and/or cancellous bone. Osteomas may be peripheral, central, or extraskeletal. Peripheral osteomas arise from the periosteum and are quite uncommon in the jaw bones. The exact aetiology and pathogenesis of peripheral osteoma are unknown. Clinically, peripheral osteomas are usually asymptomatic, but depending on the location and size of the lesion, it may cause swelling, pain, esthetic disfigurement and functional impairment...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28348619/comparative-study-of-substance-p-and-neurokinin-a-in-gingival-crevicular-fluid-of-healthy-and-painful-carious-permanent-teeth
#15
Alireza Heidari, Mahdi Shahrabi, Mehrak Rokouei, Aliakbar Amirzargar, Pegah Rahbar
BACKGROUND: It is shown that neuropeptides can be transported from pulp chamber to periodontal ligament through apical foramen and accessory canals. Therefore, clinical pulpal pain leads to expression of preinflammatory neuropeptides such as substance P (SP) and neurokinin A (NKA) in gingival crevicular fluid (GCF). This study aimed to evaluate levels of SP and NKA in GCF of carious and healthy permanent teeth, comparatively. MATERIALS AND METHODS: This cross-sectional study was performed on twenty children referred to Department of Pediatric Dentistry, Tehran University of Medical Sciences, who had a painful permanent first molar...
January 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28326724/-research-progress-on-bisphosphonate-related-osteonecrosis-of-the-jaws
#16
REVIEW
Pan Jian, Wang Qizhang, Liu Jiyuan
Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is clinically characterized by exposed bones, formation of sequestrum, pain, and halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments for this disease are currently unavailable. Thus, prevention plays an important role in the management of BRONJ...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28319279/borderline-lepromatous-leprosy-erythema-nodosum-leprosum-and-a-generalized-varicella-zoster-virus-infection
#17
Cornelis Kennedy, Bernard Naafs
We report the case of a thirty-year-old man with Mid-Borderline (BB) to Borderline Lepromatous Leprosy (BL) who was admitted to the hospital with blistering lesions on his upper and lower extremities. These lesions, which were partly filled with pus rapidly developed into erosions and ulcerations with hemorrhagic crusts. Other observations at time of admission included a tender erythematous plaque on his forehead, a drop foot on the right leg, muscle atrophy in both hands, a low grade fever, and pain and swelling in his right lower jaw...
March 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28317823/-functional-cardiovascular-assessment-in-dentists-performing-local-anesthesia-in-out-patient-settings
#18
S A Rabinovich, S N Razumova, Yu L Vasil'ev
The article presents the results of the cardiovascular changes assessment using electrocardiography (ECG) monitoring during local anesthesia in GP dentists. Selective ECG monitoring was carried out in 60 dentists aged 25-55 years (1 group - 25-34 y.o.; 2 group - 35-44 y.o.; 3 group - 45-55 y.o.) by means of portable «Valens» system. The study of stress index or the index of regulatory systems tension (IT) was conducted for 6 hours in the first day half within 1 working day. IT from 50 to 150 relative units was considered normal...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28302236/osteogenic-sarcoma-of-mandible
#19
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Osteosarcoma (OS) is a malignant neoplasm characterised by the formation of osteoid matrix by neoplastic cells. It is the most common primary malignant bone tumor accounting for 20% of all sarcomas, although its occurrence in the jaw is rare. It shows typical clinical behaviour but varied radiological and histopathological features. It presents various histological aspects. We report a case of 30-year male presented with a painful swelling of mandible, diagnosed as OS after histopathological evaluation.
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28290229/incobotulinumtoxina-injection-for-temporomandibular-joint-disorder
#20
RANDOMIZED CONTROLLED TRIAL
Amit A Patel, Michael Z Lerner, Andrew Blitzer
OBJECTIVES: Temporomandibular disorder (TMD) involves dysfunction of the temporomandibular joint and associated muscles of mastication causing pain with chewing, limitation of jaw movement, and pain. While the exact pathophysiology of TMD is not completely understood, it is thought that hyperfunction of the muscles of mastication places stress on the temporomandibular joint, leading to degeneration of the joint and associated symptoms. We hypothesize that chemodenervation of the muscles of mastication with IncobotulinumtoxinA (Xeomin) will decrease the stress on the temporomandibular joint and improve pain associated with temporomandibular joint and muscle disorder (TMJD)...
April 2017: Annals of Otology, Rhinology, and Laryngology
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