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https://www.readbyqxmd.com/read/28642568/treatment-for-bisphosphonate-related-osteonecrosis-of-the-jaw
#1
Silvia Spivakovsky
Data sourcesCochrane Oral Health Group Trials Register, CENTRAL, Medline, Embase, CancerLit, CINAHL, AMED, clinicaltrials.gov and the WHO International Trial Registry Platform. The reviewers searched six grey literature sites and contacted authors, researchers and pharmaceutical companies.Study selectionRandomised controlled trials for the treatment of BRONJ comparing interventions with other treatment or placebo were included in any setting with no age restriction.Data extraction and synthesisIndependently, two reviewers selected studies for inclusion, risk of bias and data extraction...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28638693/management-of-the-temporomandibular-joint-in-inflammatory-arthritis-involvement-of-surgical-procedures
#2
REVIEW
Rory C O'Connor, Fiona Fawthrop, Rami Salha, Andrew J Sidebottom
Many conditions may affect the temporomandibular joint (TMJ), but its incidence in individual joint diseases is low. However, inflammatory arthropathies, particularly rheumatoid and psoriatic arthritis and ankylosing spondylitis, appear to have a propensity for affecting the joint. Symptoms include pain, restriction in mouth opening, locking, and noises, which together can lead to significant impairment. Jaw rest, a soft diet, a bite splint, and medical therapy, including disease-modifying antirheumatic drugs (DMARDs) and simple analgesia, are the bedrock of initial treatment and will improve most symptoms in most patients...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28629271/expression-of-interleukin-1-and-temporomandibular-disorder-contemporary-review-of-the-literature
#3
Adam Sorenson, Kyle Hresko, Seth Butcher, Sean Pierce, Vinicius Tramontina, Rosalia Leonardi, Carla Loreto, Jose Bosio, Luis Eduardo Almeida
OBJECTIVE: Temporomandibular disorders (TMD) are a group of conditions affecting the temporomandibular joint (TMJ), leading to jaw dysfunction, joint and muscle pain, and a decrease in quality of life. A communication network of pro- and anti-inflammatory mediators called cytokines maintains the homeostasis of the TMJ. This review will focus on the Interleukin (IL) family of cytokines, which have been quantified in TMJ synovial fluids in a variety of studies. IL-1α and IL-1β have pro-inflammatory effects, while the endogenous receptor antagonist (IL-1RA) inhibits the pro-inflammatory effects of IL-1...
June 19, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28619068/late-onset-jaw-and-teeth-pain-mimicking-trigeminal-neuralgia-associated-with-chronic-vagal-nerve-stimulation-case-series-and-review-of-the-literature
#4
Gabriela Timarova, Andrej Šteňo
BACKGROUND: Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extremely rare, may not be recognized as caused by VNS. CASE PRESENTATION: Two patients with drug-resistant symptomatic epilepsy treated with chronic VNS experienced stimulation-related pain in the lower and upper jaw and teeth on the side of stimulation...
June 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28616750/systematic-review-of-oral-manifestations-related-to-hyperparathyroidism
#5
REVIEW
Benjamin Palla, Egon Burian, Riham Fliefel, Sven Otto
OBJECTIVES: We sought to identify oral symptoms found in hyperparathyroidism and compare their rate of occurrence, as well as potential variations in sequelae between primary, secondary, and tertiary hyperparathyroidism. MATERIALS AND METHODS: Database searches were performed through EMBASE and PubMed, with a continual handsearch for relevant articles. PRISMA guidelines were followed. RESULTS: Two hundred five articles including 245 patients were analyzed with data extraction...
June 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28601537/trigeminocardiac-reflex-as-the-presentation-of-maxillary-sinus-adenocarcinoma
#6
Jason M Lunt, Ahmad Al-Taee, Rachna Rawal, Fred R Buckhold
The trigeminocardiac reflex is a brainstem reflex that manifests as sudden hemodynamic dysfunction including bradycardia, hypotension, hypopnea, and gastric hypermotility due to mechanical stimulation of the trigeminal nerve. Here, the trigeminocardiac reflex was part of the initial patient presentation that led to the diagnosis of maxillary adenocarcinoma. A 54-year-old male presented to the emergency department with a two-month history of right upper jaw pain. Vital signs included blood pressure of 68/48 mmHg, heart rate of 55, and oxygen saturation of 85%...
June 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28600825/temporomandibular-dysfunction-in-adult-patients-with-myotonic-dystrophy-dm1
#7
REVIEW
C Mejersjö, S Kiliaridis
Myotonic muscle dystrophy is a systemic disease with early engagement of the facial muscles. Our aim was to study dysfunction of the temporomandibular system in patients with 'classic' dystrophia myotonica (DM1) and compare it with TMD patients and healthy controls. The study included 27 referred patients with DM1, 18 women and 9 men, aged 30-62 years, and two matched control groups: patients with temporomandibular disorders symptoms (TMD) and healthy controls, both groups were consecutive patients. The patients answered questions regarding facial pain, jaw function and dysfunction...
June 10, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28597323/stent-induced-flow-disturbances-in-the-ipsilateral-external-carotid-artery-following-internal-carotid-artery-stenting-a%C3%A2-temporary-cause-of-jaw-claudication
#8
Georgiana-Aura Giurgea, Markus Haumer, Irene Mlekusch, Schila Sabeti-Sandor, Petra Dick, Martin Schillinger, Erich Minar, Wolfgang Mlekusch
BACKGROUND: We hypothesize that stenting of the internal carotid artery can immediately impede blood flow to the external carotid artery by either plaque shift or stent coverage of the ostium, and thereby cause ischemic symptoms like ipsilateral jaw claudication. METHODS: Thirty-three patients with high-grade asymptomatic stenosis of the internal carotid artery who underwent endovascular treatment were examined by ultrasound of the external carotid artery and performed an exercise test by chewing chewing gum synchronously to an electronic metronome for 3 min...
June 9, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28593734/can-an-nti-tss-device-be-effective-as-a-first-line-therapy-in-patients-with-tmd-myofascial-pain
#9
G N Hasanoglu Erbasar, C Alpaslan, G Eroglu Inan
This study was conducted to evaluate whether integrating a nociceptive trigeminal inhibition-tension suppression system (NTI-tss) device with first-line therapy of myofascial pain, which includes guidance, assurance, counselling and behavioural changes, would be more effective in alleviating symptoms. This randomised controlled clinical trial included 40 patients who were clinically diagnosed with myofascial pain according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Patients were randomly divided into two groups: the first group comprised patients who received guidance, assurance, counselling and behavioural changes; an NTI-tss device was integrated to this protocol in the second group...
May 18, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28584778/temporomandibular-joint-pain-clinical-presentations-and-response-to-conservative-treatments-in-a-nigerian-tertiary-hospital
#10
Elijah Olufemi Oyetola, Olufunlola Motunrayo Adesina, Adeniyi Oluwadaisi, Adedotun Adewale, Opeyemi Adewole, E Anizoba
AIMS AND OBJECTIVES: The aims of this study are to determine the prevalence, pattern of presentation, and response to conservative (medical) interventions among patients who presented with temporomandibular joint (TMJ) pain in a Nigerian teaching hospital. MATERIAL AND METHODS: Consecutive patients who presented in Oral Medicine and Periodontology Clinic of Obafemi Awolowo University Teaching Hospitals' Complex on account of TMJ pain from January 2015 to December 2015 were recruited for the study...
May 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28580880/fibromyalgia-in-patients-with-chronic-ccd-and-cmd-a-retrospective-study-of-555-patients
#11
Brigitte Losert-Bruggner, Manfred Hülse, Roland Hülse
OBJECTIVE: Craniomandibular dysfunction (CMD) and craniocervical dysfunction (CCD) are clearly defined musculoskeletal pain syndromes. Relationships with fibromyalgia syndrome (FMS) have not yet been investigated. The aim of the present study is to establish possible relationships between FMS and CMD/ CCD. METHODS: In a retrospective study, 555 patients with CCD and CMD were investigated with respect to the diagnostic criteria of FMS. In addition to otolaryngologic and dental examination, an instrumental functional analysis for the diagnosis of CMD/CCD was performed...
June 5, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28578368/effect-of-pre-operatory-low-level-laser-therapy-on-pain-swelling-and-trismus-associated-with-third-molar-surgery
#12
M Petrini, M Ferrante, P Trentini, G Perfetti, G Spoto
BACKGROUND: The extraction of impacted third molars is commonly associated to pain, edema, trismus, limited jaw opening and movements. The aim of this retrospective study is to verify if pre-surgical low-level laser therapy (LLLT) associated with the extraction of impacted lower third molars could add benefits to the postoperative symptoms respect LLLT performed only after surgery. MATERIAL AND METHODS: Data from 45 patients subjected to a surgical extraction of lower third molars were pooled and divided into three groups...
June 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28576461/osteomyelitis-of-the-jaw-with-pathological-fracture-following-extraction-of-an-impacted-wisdom-tooth-a-case-report
#13
B González-Navarro, C Arranz-Obispo, R Albuquerque, E Jané-Salas, J López-López
Osteomyelitis is an infection and inflammation associated with the bone structures: bone marrow, cortical bone, periosteum, blood vessels and nerves. Although it does not have a frequent presentation, it can sometimes lead to complications such as pathological fractures or even septicemia. We present a clinical case study, to assess the relationship between osteomyelitis of the jaw and pathological fractures, after the extraction of an impacted wisdom tooth. This case highlights a rare complication following the surgical removal of mandibular third molar; a slow evolution of the pathology following an extraction should lead to close monitoring of the patient both clinically and radiographically, albeit osteomyelitis is a rare complication, it should be included as one of the differential diagnosis of persistent post-extraction pain...
May 30, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28566618/underlying-mechanisms-and-therapeutic-strategies-for-bisphosphonate-related-osteonecrosis-of-the-jaw-bronj
#14
Yasuo Endo, Hiroyuki Kumamoto, Masanori Nakamura, Shunji Sugawara, Teruko Takano-Yamamoto, Keiichi Sasaki, Tetsu Takahashi
Bisphosphonates (BPs), with a non-hydrolysable P-C-P structure, are cytotoxic analogues of pyrophosphate, bind strongly to bone, are taken into osteoclasts during bone-resorption and exhibit long-acting anti-bone-resorptive effects. Among the BPs, nitrogen-containing BPs (N-BPs) have far stronger anti-bone-resorptive effects than non-N-BPs. In addition to their pyrogenic and digestive-organ-injuring side effects, BP-related osteonecrosis of jaws (BRONJ), mostly caused by N-BPs, has been a serious concern since 2003...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28548304/delayed-onset-muscle-soreness-doms-does-not-influence-occlusal-sensitivity-and-position-sense-of-the-mandible
#15
Rosaria Bucci, Frank Lobbezoo, Ambrosina Michelotti, Christina Orfanou, Michail Koutris
BACKGROUND: Masticatory muscle-pain patients often complain about sensorimotor changes, but the effects of pain on the psychophysical properties remain unclear. This study aimed to investigate the effects of Delayed-Onset Muscle Soreness (DOMS) on the jaw's position sense (PS) and occlusal sensitivity (OS). METHODS: Twelve participants underwent intense concentric-eccentric jaw exercises. Self-reported muscle fatigue and pain, pain-free maximum mouth opening (MMO), pain pressure thresholds (PPTs) at right and left masseter and right and left anterior temporalis, maximum voluntary bite force (MVBF), PS, and OS were recorded before, immediately after, 24h, 48h, and one week after the exercises...
May 26, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28536539/mental-status-as-a-common-factor-for-masticatory-muscle-pain-a-systematic-review
#16
REVIEW
Mieszko Wieckiewicz, Marek Zietek, Joanna Smardz, Dobrochna Zenczak-Wieckiewicz, Natalia Grychowska
Masticatory muscle pain (MMP) is the primary reason for chronic non-odontogenic orofacial pain in the human population. MMP has become a considerable social problem, which affects about 12-14% of the adult population and is 1.5-2 times more frequent in women than in men. This term defines a pain which has its origins in the masticatory muscles. Although MMP is typically felt in the face, jaws, and preauricular area, MMP can radiate to the ear, teeth, head, and neck. This systematic review explains the relationship between MMP and common mental states, such as anxiety, depression, mood and stress-related disorders, and is reported in accordance with PRISMA guidelines...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28502207/symptoms-in-the-masticatory-system-and-related-quality-of-life-in-prospective-orthognathic-patients
#17
Riikka Pietilä, Mimmi Tolvanen, Timo Peltomäki, Anna-Liisa Svedström-Oristo
OBJECTIVE: The aim of this study was to investigate the relation between orthognathic patients' self-reported symptoms in the head and neck region and their quality of life (QoL). MATERIAL AND METHODS: Participants included were consecutive patients (n = 50) referred to the assessment of orthognathic treatment need and voluntary first-year university students (n = 29). All participants filled in the Orthognathic Quality of Life Questionnaire (OQLQ) and a structured diary created by the authors...
May 13, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28495394/chronic-temporomandibular-joint-pain-two-cases-of-osteoid-osteoma-and-a-review-of-the-literature
#18
REVIEW
J T Deferm, S C A Steens, D Vriens, E M Bekers, S I Kalaykova, W A Borstlap
Osteoid osteoma is a benign bone tumour with self-limiting growth potential occurring in any part of the body. Two rare cases of a pathologically proven osteoid osteoma invading the temporomandibular joint (TMJ) are reported herein. This article also reviews the cases of osteoid osteoma of the craniofacial complex reported in the English-language literature to date. Although the clinical presentation of osteoid osteoma in the jaw differs from that of osteoid osteoma in the more common locations, the radiographic features are similar...
May 8, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28494686/clinical-pharmacology-efficacy-and-safety-of-selexipag-for-the-treatment-of-pulmonary-arterial-hypertension
#19
REVIEW
Shirin Bruderer, Noémie Hurst, Tatiana Remenova, Jasper Dingemanse
Selexipag is the first oral, non-prostanoid, selective prostacyclin receptor (IP receptor) agonist, approved for the long-term treatment of pulmonary arterial hypertension (PAH) in adult patients. Areas covered: This article reviews the clinical pharmacology, efficacy, and safety of selexipag in the treatment of PAH. Expert opinion: Selexipag is the first oral drug that selectively targets the prostacyclin pathway, and has evidence of long-term efficacy and safety. In the global phase 3 study GRIPHON (NCT01106014) in PAH patients, selexipag significantly reduced the risk of the primary composite outcome of morbidity/mortality (M/M)...
June 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28492455/reevaluating-antidepressant-selection-in-patients-with-bruxism-and-temporomandibular-joint-disorder
#20
Royce Rajan, Ye-Ming Sun
Temporomandibular joint disorder (TMD) is a broad pain disorder that refers to several conditions affecting the temporomandibular joint of the jaw and the muscles of mastication. As with most pain disorders, a high prevalence of depression and anxiety is associated with TMD. Research has shown that selective serotonin reuptake inhibitors (SSRIs), the first-line drug therapy for major depressive disorder, may not be suitable for TMD patients because SSRIs can induce teeth-grinding, otherwise known as bruxism...
May 2017: Journal of Psychiatric Practice
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