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https://www.readbyqxmd.com/read/28902106/fine-tuning-the-predictive-model-for-proximal-junctional-failure-in-surgically-treated-patients-with-adult-spinal-deformity
#1
Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Osahiko Tsuji, Narihito Nagoshi, Takashi Asazuma, Ken Ishii, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
STUDY DESIGN: Multi-center retrospective study. OBJECTIVE: To validate and improve the predictive model for proximal junctional failure (PJF) with or without the bone mineral density (BMD) score. SUMMARY OF BACKGROUND DATA: PJF is a serious complication of surgery for adult spinal deformity (ADS). A predictive model for PJF was recently reported that has good accuracy, but does not include BMD, a known PJF risk factor, as a variable. METHODS: We included 145 surgically treated ASD patients who were older than 50 at the time of surgery and had been followed up for at least 2 years...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28899595/peripheral-nerve-pathology-at-fixed-stage-in-spinal-muscular-atrophy-with-respiratory-distress-type-1
#2
Azusa Ikeda, Sumimasa Yamashita, Yu Tsuyusaki, Mio Tanaka, Yukichi Tanaka, Akihiro Hashiguchi, Hiroshi Takashima, Tomohide Goto
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is characterized by severe respiratory failure due to diaphragmatic paralysis and distal muscular weakness in early infancy. After an initial decline in respiratory state and motor function until 1-2years of age, residual capabilities reach a plateau. We report the peripheral neuropathological findings of a patient with SMARD1 at 1year and 1month of age, when his muscle strength and respiratory symptoms had deteriorated and then stabilized for several months...
September 9, 2017: Brain & Development
https://www.readbyqxmd.com/read/28894688/current-diagnosis-and-management-of-cervical-spondylotic-myelopathy
#3
REVIEW
Joshua Bakhsheshian, Vivek A Mehta, John C Liu
STUDY DESIGN: Review. OBJECTIVES: Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28890806/postlaminectomy-membrane-with-dynamic-spinal-cord-compression-disclosed-with-computed-tomographic-myelography-a-case-report-and-literature-review
#4
Takahiro Kitahara, Junya Hanakita, Toshiyuki Takahashi
INTRODUCTION: It has been hypothesized that postoperative epidural scar, postlaminectomy membrane, may be responsible for late neurological deterioration after cervical laminectomy in some cases, but there is a lack of radiological studies in the literature showing the clinical significance of postlaminectomy membrane. We describe a rare case with radiological evidence of dynamic spinal cord compression caused by the postlaminectomy membrane, which may have been related to neurological deterioration...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28884071/increased-risk-of-sses-in-bone-only-metastatic-breast-cancer-patients-treated-with-zoledronic-acid
#5
Masashi Yanae, Shinichiro Fujimoto, Kaori Tane, Maki Tanioka, Kimiko Fujiwara, Masanobu Tsubaki, Yuzuru Yamazoe, Yoshiyuki Morishima, Yasutaka Chiba, Shintaro Takao, Yoshifumi Komoike, Junji Tsurutani, Kazuhiko Nakagawa, Shozo Nishida
BACKGROUND: Bone represents one of the most common sites to which breast cancer cells metastasize. Patients experience skeletal related adverse events (pathological fractures, spinal cord compressions, and irradiation for deteriorated pain on bone) even during treatment with zoledronic acid (ZA). Therefore, we conducted a retrospective cohort study to investigate the predictive factors for symptomatic skeletal events (SSEs) in bone-metastasized breast cancer (b-MBC) patients. METHODS: We retrospectively collected data on b-MBC patients treated with ZA...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28882602/neurosurgical-aspects-of-dialysis-related-spinal-amyloidosis-report-of-three-cases-and-a-review-of-the-literature
#6
M Dalolio, F Lucarella, P Rampini, G P Bulfamante, S Aldea, P Graveleau, S Gaillard, P Scarone
BACKGROUND AND PURPOSE: Osteoarticular manifestations of beta-2 microglobulin amyloidosis are often diagnosed in long-term dialyzed patients. However, spinal involvement is rare (10-25% of patients), and generally not associated with neurological deterioration. Compression of the spinal cord or roots is extremely rare, and probably under-recognized. METHODS: The authors describe three cases of spinal stenosis presenting with neurological signs in long-term dialyzed patients, prospectively collected over 2 years in two different institutions and treated by surgical decompression...
September 4, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28882524/activities-performed-and-treatments-conducted-prior-to-consultation-with-a-spine-surgeon-are-patients-and-clinicians-following-evidence-based-clinical-practice-guidelines
#7
Elliot I Layne, Darren M Roffey, Matthew J Coyle, Philippe Phan, Stephen P Kingwell, Eugene K Wai
BACKGROUND CONTEXT: Clinical practice guidelines (CPGs) are designed to ensure that evidence-based treatment is easily put into action. Whether patients and clinicians follow these guidelines is equivocal. PURPOSE: To examine how many patients complaining of low back pain (LBP) underwent evidence-based non-operative treatment in line with CPG recommendations prior to consultation with a spine surgeon, and to evaluate any associations between adherence to CPG recommendations and baseline factors...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28880140/-diving-accident-induced-arterial-gas-embolism
#8
P D Nijk, T P van Rees Vellinga, J M van Lieshout, M I Gaakeer
BACKGROUND: During scuba diving, nitrogen dissolves into the body tissues due to elevated pressure under water. During a sudden drop in pressure due to a rapid return to the water surface, arterial gas embolism can arise from pulmonary barotrauma. In a later phase, nitrogen bubbles can also arise in the venous circulation (decompression sickness). Arterial bubbles can incur vascular damage, obstruction, hypoxia and infarction. CASE DESCRIPTION: A 53-year-old healthy sport diver presented at the emergency department in a hypovolemic shock with progressive paresis of all the extremities...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28874974/evaluation-of-sagittal-spine-pelvis-lower-limb-alignment-in-elderly-women-with-pelvic-retroversion-while-standing-and-walking-using-a-three-dimensional-musculoskeletal-model
#9
Ken Sasaki, Michio Hongo, Naohisa Miyakoshi, Toshiki Matsunaga, Shin Yamada, Hiroaki Kijima, Yoichi Shimada
STUDY DESIGN: In vivo biomechanical study using a three-dimensional (3D) musculoskeletal model for elderly individuals with or without pelvic retroversion. PURPOSE: To evaluate the effect of pelvic retroversion on the sagittal alignment of the spine, pelvis, and lower limb in elderly females while standing and walking. OVERVIEW OF LITERATURE: Patients with hip-spine syndrome have concurrent hip-joint and spine diseases. However, the dynamic sagittal alignment between the hip joint and spine has rarely been investigated...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28874972/microsurgical-treatment-of-sporadic-and-von-hippel-lindau-disease-associated-spinal-hemangioblastomas-a-single-institution-experience
#10
Joe M Das, Krishnakumar Kesavapisharady, Saravanan Sadasivam, Suresh Narayanan Nair
STUDY DESIGN: Retrospective cohort study. PURPOSE: To examine the clinical profile and surgical complications in patients with spinal hemangioblastomas and to evaluate the long-term outcome in them. OVERVIEW OF LITERATURE: Although considered to be histologically benign, hemangioblastomas may cause significant neurological deficits. The proportion of spinal hemangioblastomas associated with von Hippel-Lindau (VHL) disease has been estimated be 13%-59%...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28871507/delayed-post-operative-tension-pneumocephalus-and-pneumorrhachis
#11
D C Kieser, D T Cawley, C Tavolaro, T Cloche, I Obeid, V Pointillart, J M Vital, O Gille
INTRODUCTION: The incidence of pneumocephalus and pneumorrhachis after spinal surgery is unknown, with a paucity of literature on this complication. MATERIALS AND METHODS: We present the first published case of delayed onset tension pneumocephalus and pneumorrhachis associated with spinal surgery. RESULTS: This complication occurred from a cerebro-spinal fluid (CSF) leak after posterior instrumentation removal and was successfully treated with emergent wound debridement and the formation of a CSF fistula...
September 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28871219/p2x7-receptor-activation-modulates-autophagy-in-sod1-g93a-mouse-microglia
#12
Paola Fabbrizio, Susanna Amadio, Savina Apolloni, Cinzia Volonté
Autophagy and inflammation play determinant roles in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), an adult-onset neurodegenerative disease characterized by deterioration and final loss of upper and lower motor neurons (MN) priming microglia to sustain neuroinflammation and a vicious cycle of neurodegeneration. Given that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm signal implicated in ALS, and that P2X7 affects autophagy in immune cells, we have investigated if autophagy can be directly triggered by P2X7 activation in primary microglia from superoxide dismutase 1 (SOD1)-G93A mice...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28867317/extensive-mirror-image-neurofibromas-of-the-entire-spine-resulting-in-spastic-tetraplegia
#13
Mark Bigder, Paul Szelemej, Neil Berrington
Neurofibromatosis 1 (NF1) is associated with increased incidence of spinal tumors including neurofibromas. The majority of NF1 associated spine neurofibromas are asymptomatic, however a minority of patients will experience neurological symptoms which can range from mild paraesthesias, radiculopathy, myelopathy and focal weakness to quadriplegia in extreme cases. We present a 21 year old male diagnosed with NF1 in infancy and followed for multiple mirror-image neurofibromas involving the entire spine. He was asymptomatic until age 14 when he developed neck pain and progressive tetraplegia with MRI showing severe cord compression secondary to bilateral C2 neurofibromas...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28866064/surgical-outcomes-of-posterolateral-sulcus-approach-for-spinal-intramedullary-tumors-tumor-resection-and-functional-preservation
#14
Toshihiro Takami, Kentaro Naito, Toru Yamagata, Shinichi Kawahara, Kenji Ohata
BACKGROUND: Selection of the access myelotomy is a key issue in surgery for spinal intramedullary tumors. This study focused on surgical outcomes with the posterolateral sulcus (PLS) approach, equivalent to dorsal root entry zone myelotomy. METHODS: This retrospective study of the 10-year period from 2007 to 2016 included 90 cases of spinal intramedullary lesions (99 operations). A PLS approach was indicated for intramedullary lesions situated laterally in the spinal cord showing no contact with the spinal cord surface...
August 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28842365/spinal-deformity-changes-in-children-with-long-term-vertical-expandable-prosthetic-titanium-rib-veptr-treatment
#15
Andrea S Gantner, Lena Braunschweig, Konstantinos Tsaknakis, Heiko M Lorenz, Anna K Hell
BACKGROUND CONTEXT: In several studies, vertical expandable prosthetic titanium rib (VEPTR) implants have shown good scoliosis control in children with the longest reported follow-up (f/u) of 3.6 years. For growing rods, recent studies suggest a decreased efficiency of correction starting just after that time. To our knowledge, no long-term results of children with VEPTR treatment are available. PURPOSE: To evaluate spinal deformity in scoliotic children and to investigate correction potential of VEPTR implants at several time points of treatment, particularly after long-term f/u...
August 22, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28840353/recurrence-of-ossification-of-ligamentum-flavum-at-the-same-intervertebral-level-in-the-thoracic-spine-a-report-of-two-cases-and-review-of-the-literature
#16
Haruo Kanno, Tadahisa Takahashi, Toshimi Aizawa, Ko Hashimoto, Eiji Itoi, Hiroshi Ozawa
PURPOSE: Ossification of the ligamentum flavum (OLF) is a possible cause of thoracic myelopathy. We report two rare cases with recurrent thoracic myelopathy caused by OLF markedly re-extended at the same intervertebral level after the primary surgery. METHODS: Both patients had thoracic myelopathy caused by OLF and underwent decompressive laminectomy and resection of the OLF in the primary surgery. However, the neurological conditions gradually deteriorated following recovery after the primary surgery due to the recurrent OLF at the same intervertebral level...
August 24, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28840068/a-case-of-symptomatic-spinal-dural-arteriovenous-fistula-after-high-volume-lumbar-puncture
#17
Thomas Noh, Rahul Chandra, Jimmy Kim, Ian Lee
BACKGROUND: Spinal dural arteriovenous fistulas (DAVFs) are rare lesions that lead to venous congestion and ischemic injury resulting in neurologic deterioration. Here we present a patient diagnosed with glioblastoma multiforme (GBM) who became symptomatic from a spinal DAVF after a diagnostic high-volume lumbar puncture (LP). CASE DESCRIPTION: When a 72-year-old female developed partial seizures in her left upper extremity without other focal neurological deficits, she underwent a magnetic resonance imaging (MRI) scan of the brain...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28835284/maintaining-immobilisation-devices-on-trauma-patients-during-ct-a-feasibility-study
#18
Pål Johan Stokkeland, Erlend Andersen, Maria Myhre Bjørndal, Arne Morten Mikalsen, Sindre Aslaksen, Per Kristian Hyldmo
BACKGROUND: To reduce the possibility of secondary deterioration of spinal injuries, it is desirable to maintain the spinal immobilisation that is applied in the prehospital setting throughout computed tomography (CT) scanning. A previous study found that metallic components within the inflation valve of the vacuum mattresses caused CT artefacts. The aim of our study was to investigate the effect of vacuum mattresses with plastic valves on CT artefacts, the radiation dose, and noise compared to a trauma transfer board and the spine boards currently used in our trauma system...
August 23, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28835232/full-fusion-of-proximal-thoracic-curve-helps-to-prevent-postoperative-cervical-tilt-in-lenke-type-2-adolescent-idiopathic-scoliosis-patients-with-right-elevated-shoulder
#19
Jun Jiang, Bang-Ping Qian, Yong Qiu, Bin Wang, Yang Yu, Ze-Zhang Zhu
BACKGROUND: To date, no study had reported the phenomenon of deteriorated postoperative cervical tilt in Lenke type 2 adolescent idiopathic scoliosis patients. The purpose of this study is to evaluate the cervical tilt in Lenke type 2 adolescent idiopathic scoliosis patients with right-elevated shoulder treated by either full fusion or partial/non fusion of the proximal thoracic curve. METHODS: A total of 30 Lenke type 2 AIS patients with preoperative right-elevated shoulder underwent posterior spinal instrumentation from 2009 to 2011 were included in this study...
August 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28829887/correlation-analysis-of-adamts-4-vcam-1-and-tak1-expression-in-cartilage-tissue-from-spine-tuberculosis
#20
Z X Qiu, Z S Sha, X M Che, M Y Wang
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1) and closely related to a variety of pathophysiological processes. This study intended to explore the expression of ADAMTS-4, VCAM-1, and TAK1 in cartilage tissue obtained from spinal tuberculosis patients and their inter-relationships, aiming to provide new treatment approaches for spinal tuberculosis...
August 17, 2017: Genetics and Molecular Research: GMR
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