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JOURNAL ARTICLE
Rand Mohammed Al-Sagheer, Ali J Addie, Lamis A Al-Taee
To evaluate the efficiency and effectiveness of three minimally invasive (MI) techniques in removing deep dentin carious lesions. Forty extracted carious molars were treated by conventional rotary excavation (control), chemomechanical caries removal agent (Brix 3000), ultrasonic abrasion (WOODPECKER, GUILIN, China); and Er, Cr: YSGG laser ablation (BIOLASE San Clemente, CA, USA). The assessments include; the excavation time, DIAGNOdent pen, Raman spectroscopy, Vickers microhardness, and scanning electron microscope combined with energy dispersive X-ray spectroscopy (SEM-EDX)...
March 26, 2024: Scientific Reports
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JOURNAL ARTICLE
Tao Huang, Xingjie Huang, Xueying Cui, Qinghua Dong
The aim of the present study was to identify the independent risk factors and prognostic indicators for atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) and to develop predictive nomogram models. This retrospective study included a total of 286 patients with COPD who were admitted to the Second Affiliated Hospital of Guilin Medical College between January 2020 and May 2022. The average age of the patients was 77.11±8.67 years. Based on the presence or absence of AF, the patients were divided into two groups: The AF group (n=87) and the non-AF group (n=199)...
April 2024: Experimental and Therapeutic Medicine
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JOURNAL ARTICLE
Pleural effusion portends a poor prognosis in patients on continuous ambulatory peritoneal dialysis.
Fengping Zhang, Ting Xiang, Xiaoran Feng, Guilin Zhang, Yu Liu, Luohua Li
AIMS: Pleural effusion is not an infrequent complication in patients undergoing continuous ambulatory peritoneal dialysis. However, there is not adequate data to evaluate pleural effusion and prognosis in clinical practice. In this study, we validated this potential association by a multicenter cohort. METHODS: We screened 1,162 patients who met the inclusion criteria with PD. According to the existence of pleural effusion on stable dialysis (4-8 weeks after dialysis initiation), the participants were divided into pleural effusion and non-pleural effusion groups...
2024: PloS One
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JOURNAL ARTICLE
Jiannan Qiu, Lin Chen, Ling Zhang, Fangying Xu, Congcong Zhang, Guilin Ren, Kaixin Chang, Guonong He, Zhongyan Du, Yifei Le, Zhiling Yu, Songtao Li, Qingsheng Liu, Xiaobing Dou
BACKGROUND: Current evidence indicates a rising global prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), which is closely associated to conditions such as obesity, dyslipidemia, insulin resistance, and metabolic syndrome. The relationship between the gut microbiome and metabolites in NAFLD is gaining attention understanding the pathogenesis and progression of dysregulated lipid metabolism and inflammation. The Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed in clinical practice for alleviating hyperlipidemia and symptoms related to metabolic disorders...
September 23, 2023: Phytomedicine
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JOURNAL ARTICLE
Qianqian Zhu, Fengchong Wang, Dengfeng Gao, Jie Gao, Guilin Li, Deling Jiao, Gaoxiang Zhu, Kaixiang Xu, Jianxiong Guo, Tianzhi Chen, Suying Cao, Minglei Zhi, Jinying Zhang, Yingjie Wang, Xiaowei Zhang, Danru Zhang, Yixuan Yao, Jian Song, Hong-Jiang Wei, Jianyong Han
Genome integration-free pig induced pluripotent stem cells (iPSCs) bring tremendous value in pre-clinical testing of regenerative medicine, as well as conservation and exploitation of endangered or rare local pig idioplasmatic resources. However, due to a lack of appropriate culture medium, efficient induction and stable maintenance of pig iPSCs with practical value remains challenging. Here, we established an efficient induction system for exogenous gene-independent iPSCs under chemically defined culture condition previously used for generation of stable pig pre-gastrulation epiblast stem cells (pgEpiSCs)...
May 15, 2023: Cell Proliferation
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JOURNAL ARTICLE
Yiwei Fang, Zheng Zhang, Yun Zhao, Guoqiang Sun, Meilin Peng, Chunyan Liu, Guilin Yi, Kai Zhao, Hui Yang
AIMS: To explore the maternal metabolic changes of fetal congenital heart disease (FCHD), and screen metabolic markers to establish a practical diagnostic model. METHODS: Maternal peripheral serum from 17 FCHD and 63 non-FCHD pregnant were analyzed by Ultra High-performance Liquid Chromatography-Mass/Mass (UPLC-MS/MS). RESULTS: In the FCHD and the non-FCHD, 132 metabolites were identified, including 35 differential metabolites enriched in the purine, caffeine, primary bile acid, and arachidonic acid metabolism pathway...
April 8, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
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JOURNAL ARTICLE
Xuyu Chen, Wenjun Yin, Jie Wu, Yongbin Luo, Jing Wu, Guangming Li, Jinfeng Jiang, Yong Yao, Siyu Wan, Guilin Yi, Xiaodong Tan
OBJECTIVE: To develop a prediction nomogram for the risk of lung-related diseases (LRD) in construction workers. METHODS: Seven hundred and fifty-two construction workers were recruited. A self- designed questionnaire was performed to collected relevant information. Chest X-ray was taken to judge builders' lung health. The potential predictors subsets of the risk of LRD were screened by the least absolute shrinkage and selection operator regression and univariate analysis, and determined by using multivariate logistic regression analysis, then were used for developing a prediction nomogram for the risk of LRD...
2022: Frontiers in Public Health
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JOURNAL ARTICLE
Guilin Ren, Gang Ke, Rui Huang, Qingrong Pu, Jian Zhao, Qin Zheng, Ming Yang
Volatile oil from traditional Chinese medicine has various biological activities and has pharmacological activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clinical practice. However, the development of their clinical applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled...
May 17, 2022: Scientific Reports
#9
JOURNAL ARTICLE
Peng Li, Meiting Li, Lili Tian, Jiyue You, Jie Xiao, Guilin Xiang, Xizhi Ding, Rong Jiang, Juan Liao
BACKGROUND: The success or failure of anesthesia determines the success or failure of surgery. Therefore, more attention should be paid to the training of students majoring in clinical anesthesia. Traditional teaching methods rely on teacher explanation, and thus students depend greatly on their teachers. In recent years, case analysis teaching has become increasingly popular as an educational mode and is widely praised by students. Many studies have shown that case analysis teaching can not only improve students' enthusiasm but also enable students to apply what they have learned into clinical practice...
January 2022: Annals of Palliative Medicine
#10
JOURNAL ARTICLE
Yanqiong Chen, Chao Zhang, Cheng Pan, Yunkui Yang, Jin Liu, Jialing Lv, Guilin Pan
BACKGROUND: Lung cancer is the leading cause of death among cancer patients worldwide. Close to 85% of lung cancer pathology types are nonsmall cell lung cancer (NSCLC). With advances in medicine, the survival rate of early-stage NSCLC has improved. Nevertheless, about 70% of patients are diagnosed at an advanced stage, and chemotherapy is the primary treatment option. Chemotherapy causes toxic side effects such as bone marrow suppression, gastrointestinal reactions, and damage to vital organs, which are difficult for patients to tolerate...
November 5, 2021: Medicine (Baltimore)
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JOURNAL ARTICLE
Jia-Cheng Shi, Xiao-Huan Chen, Qiong Yang, Cai-Mei Wang, Qian Huang, Yan-Ming Shen, Jian Yu
Currently, the most widely used screening methods for hyperuricemia (HUA) involves invasive laboratory tests, which are lacking in many rural hospitals in China. This study explored the use of non-invasive physical examinations to construct a simple prediction model for HUA, in order to reduce the economic burden and invasive operations such as blood sampling, and provide some help for the health management of people in poor areas with backward medical resources. Data of 9252 adults from April to June 2017 in the Affiliated Hospital of Guilin Medical College were collected and divided randomly into a training set (n = 6364) and a validation set (n = 2888) at a ratio of 7:3...
December 2, 2021: Scientific Reports
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JOURNAL ARTICLE
Lianqun Qiu, Jie Xu, Guilin Tang, Sa A Wang, Pei Lin, Chi Young Ok, Sophia Garces, C Cameron Yin, Mahsa Khanlari, Francisco Vega, L Jeffrey Medeiros, Shaoying Li
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm characterized by t(11;14) (q13;q32) and cyclin D1 overexpression in >95% of cases. Classic MCL cases are composed of a monotonous population of small- to medium-sized lymphocytes with irregular nuclear contours that are positive for cyclin D1 and SOX11 and negative for CD23 and CD200. By contrast, occasional MCL cases express CD23 and CD200 but lack SOX11 and morphologically and immunophenotypically resemble chronic lymphocytic leukemia (CLL), termed as CLL-like MCL in this study...
January 2022: Human Pathology
#13
REVIEW
Wenzhen Li, Wenyu Ruan, Guilin Yi, Zhenlong Chen, Dongming Wang
AIMS: Previous studies have explored the association between noise exposure and risk of metabolic syndrome (MetS); however, the results remain inconclusive. METHODS: PubMed and Web of Science databases were searched through December, 2020, multivariate-adjusted relative risks (RRs) were pooled by using random-effects models. Subgroup analysis was also conducted stratifying by gender, study location, study design, source of noise, study quality, adjusting for smoking, drinking, body mass index, physical activity and shift work...
July 7, 2021: Diabetes Research and Clinical Practice
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JOURNAL ARTICLE
Qian Han, Xiaobo Chen, Xin Xu, Weiping Qian, Gui Zhao, Mengmeng Mao, Bingpeng Guo, Shu Xia, Guilin Peng, Jianxing He, Yingying Gu, Shiyue Li, Qun Luo
The application of transbronchial lung cryobiopsy (TBLC) and uniportal and tubeless video-assisted thoracic surgery (UT-VATS) in the multidisciplinary diagnosis of interstitial lung disease (ILD) has not been demonstrated in real-world clinical practice. This prospective study included 137 patients with no definitive diagnosis who were the subject of two multidisciplinary discussion (MDD) sessions. As indicated in the first MDD, 67 patients underwent UT-VATS and 70 underwent TBLC. The specificity of biopsy information and its contribution to final MDD diagnosis were evaluated in the second MDD...
2021: Frontiers in Molecular Biosciences
#15
JOURNAL ARTICLE
Yifei Chen, Jin Nie, Xiangsheng Li, Tao Fan, Xiaowen Deng, Dan Liang, Guilin Song
Background: As a type of malignant tumor, head and neck squamous cell carcinoma (HNSCC) seriously threatens human health. This study is aimed at constructing a new, reliable prognostic model. Method: The gene expression profile data of HNSCC patients were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases. The immune-related differentially expressed genes (IRDEGs) related to HNSCC were identified. We then used Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis to explore IRDEGs related to the HNSCC prognosis and to construct and validate a risk scoring model and used ESTIMATE to evaluate tumor immune infiltration in HNSCC patients...
2021: Journal of Immunology Research
#16
JOURNAL ARTICLE
Tao Jiang, Do-Hyun Nam, Zvi Ram, Wai-Sang Poon, Jiguang Wang, Damdindorj Boldbaatar, Ying Mao, Wenbin Ma, Qing Mao, Yongping You, Chuanlu Jiang, Xuejun Yang, Chunsheng Kang, Xiaoguang Qiu, Wenbin Li, Shaowu Li, Ling Chen, Xuejun Li, Zhixiong Liu, Weimin Wang, Hongmin Bai, Yu Yao, Shouwei Li, Anhua Wu, Ke Sai, Guilin Li, Kun Yao, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Wei Zhang, Chuanbao Zhang, Baoshi Chen, Gan You, Yongzhi Wang, Yinyan Wang, Zhaoshi Bao, Pei Yang, Xing Fan, Xing Liu, Zheng Zhao, Zheng Wang, Yiming Li, Zhiliang Wang, Guanzhang Li, Shengyu Fang, Lianwang Li, Yanwei Liu, Shuai Liu, Xia Shan, Yuqing Liu, Ruichao Chai, Huimin Hu, Jing Chen, Wei Yan, Jinquan Cai, Hongjun Wang, Lingchao Chen, Yuan Yang, Yu Wang, Lei Han, Qixue Wang
To follow the revision of the fourth edition of WHO classification and the recent progress on the management of diffuse gliomas, the joint guideline committee of Chinese Glioma Cooperative Group (CGCG), Society for Neuro-Oncology of China (SNO-China) and Chinese Brain Cancer Association (CBCA) updated the clinical practice guideline. It provides recommendations for diagnostic and management decisions, and for limiting unnecessary treatments and cost. The recommendations focus on molecular and pathological diagnostics, and the main treatment modalities of surgery, radiotherapy, and chemotherapy...
February 28, 2021: Cancer Letters
#17
REVIEW
Guilin Chen, Armel Jackson Seukep, Mingquan Guo
Marine drugs have long been used and exhibit unique advantages in clinical practices. Among the marine drugs that have been approved by the Food and Drug Administration (FDA), the protein-ligand interactions, such as cytarabine-DNA polymerase, vidarabine-adenylyl cyclase, and eribulin-tubulin complexes, are the important mechanisms of action for their efficacy. However, the complex and multi-targeted components in marine medicinal resources, their bio-active chemical basis, and mechanisms of action have posed huge challenges in the discovery and development of marine drugs so far, which need to be systematically investigated in-depth...
October 30, 2020: Marine Drugs
#18
JOURNAL ARTICLE
Taoyang Yuan, Jianyou Ying, Zhentao Zuo, Lu Jin, Songbai Gui, Zhixian Gao, Guilin Li, Rui Wang, Yazhuo Zhang, Chuzhong Li
Background: Malignant high-grade gliomas are characterized by infiltration and destruction of surrounding brain tissue. Alterations in the contrahemispheric brain structure and their roles that may offer prognostically valuable information have not been investigated in high-grade gliomas. Methods: In total, 153 patients with unilateral glioma (low-grade, n = 77; high-grade, n = 76) and 115 healthy controls (HCs) were recruited and scanned with 3-D T1 imaging. The gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volume in the contrahemisphere were examined...
2020: Frontiers in Oncology
#19
REVIEW
Zhenya Tang, Lu Wang, Guilin Tang, L Jeffrey Medeiros
In 2011, the Vysis Break Apart ALK fluorescence in situ hybridization (FISH) assay was approved by the United States Food and Drug Administration as a companion diagnostic for detecting ALK rearrangement in lung cancer patients who may benefit from treatment of tyrosine kinase inhibitor therapy. This assay is the current "gold standard". According to updated ALK testing guidelines from the College of American Pathologists, the International Association for the Study of Lung Cancer and the Association for Molecular Pathology published in 2018, ALK immunohistochemistry is formally an alternative to ALK FISH, and simultaneous detection of multiple hot spots, including, at least, ALK , ROS1 , RET , MET , ERBB2 , BRAF and KRAS genes is also recommended while performing next generation sequencing (NGS)-based testing...
August 13, 2019: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
Ling Dai, Guangdong Pan, Xiaojia Liu, Jiang Huang, Zhiqing Jiang, Xiaobao Zhu, Xinli Gan, Qing Xu, Ning Tan
Purpose: The identification of prognostic markers for colorectal cancer (CRC) is needed for clinical practice. Fructose-bisphosphate aldolase A (ALDOA) and DEAD box p68 RNA helicase (DDX5) are commonly overexpressed in cancer and correlate with tumorigenesis. However, association between expression of ALDOA and DDX5, and CRC outcome has not been reported. Patients and methods: We used 141 formalin-fixed paraffin-embedded (FFPE) specimens collected from 105 patients with CRC treated at the Affiliated Hospital of Guilin Medical University and the People's Hospital of Liuzhou...
2018: Cancer Management and Research
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