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Clinical practice guilines

Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan, Zhaosheng Qian
Butyrylcholinesterase (BChE) mainly contributing to plasma cholinesterase activity is an important indicator for routinely diagnosing liver function and organophosphorus poisoning in clinical diagnosis, but its current assays are scarce and frequently suffer from some significant interference and instability. Herein, we report a redox-controlled fluorescence nanoswtich based on reversible disulfide bonds, and further develop a fluorometric assay of BChE via thiol-triggered disaggregation-induced emission. Thiol-functionalized carbon quantum dots (thiol-CQDs) with intense fluorescence is found to be responsive to hydrogen peroxide, and their redox reaction transforms thiol-CQDs to nonfluorescent thiol-CQD assembly...
February 6, 2018: Analytical Chemistry
Leomar Y Ballester, Jason T Huse, Guilin Tang, Gregory N Fuller
Until recently, the diagnosis of brain tumors was primarily based on microscopic examination of hematoxylin and eosin-stained tissue sections. The updated World Health Organization (WHO) Classification of Tumours of the Central Nervous System incorporates genetic alterations into the classification system, with the goal of creating more homogenous disease categories with greater prognostic value. Hence, under the new classification system, the diagnosis of diffuse gliomas incorporates the evaluation of mutations in the IDH1 and IDH2 genes and simultaneous deletion of chromosomes 1p and 19q...
November 2017: Human Pathology
Tao Jiang, Ying Mao, Wenbin Ma, Qing Mao, Yongping You, Xuejun Yang, Chuanlu Jiang, Chunsheng Kang, Xuejun Li, Ling Chen, Xiaoguang Qiu, Weimin Wang, Wenbin Li, Yu Yao, Shaowu Li, Shouwei Li, Anhua Wu, Ke Sai, Hongmin Bai, Guilin Li, Baoshi Chen, Kun Yao, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Jinquan Cai, Wei Zhang, Hongjun Wang, Lingchao Chen, Chuanbao Zhang, Pei Yang, Wei Yan, Zhixiong Liu, Huimin Hu, Jing Chen, Yuqing Liu, Yuan Yang, Zheng Wang, Zhiliang Wang, Yongzhi Wang, Gan You, Lei Han, Zhaoshi Bao, Yanwei Liu, Yinyan Wang, Xing Fan, Shuai Liu, Xing Liu, Yu Wang, Qixue Wang
The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologists and clinical trial experts. The task made clearer and more transparent choices about outcomes considered most relevant through searching the references considered most relevant and evaluating their value...
June 1, 2016: Cancer Letters
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