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Post pericardiotomy syndrome

Rachel Wamboldt, Gianluigi Bisleri, Benedict Glover, Sohaib Haseeb, Gary Tse, Tong Liu, Adrian Baranchuk
Post-pericardiotomy syndrome is a well-recognized inflammatory phenomenon that commonly occurs in patients following cardiac surgery. Due to the increased morbidity and resource utilization associated with this condition, research has recently focused on ways of preventing its prevention this condition; primarily using colchicine, NSAIDs and corticosteroids. Areas covered: This systematic review summarizes the three clinical studies that have used corticosteroids for PPS primary prevention in the perioperative period...
June 2018: Expert Review of Cardiovascular Therapy
Peter S Y Yu, Vikki W K Ng, Rainbow W H Lau, Calvin S H Ng
A 11-year-old boy presented with refractory fever and dyspnoea after Nuss procedure. Massive pericardial effusion was detected on computer tomography scan performed under corticosteroid cover for his asthmatic history. With rapid clinical improvement following corticosteroids, a clinical diagnosis of post-pericardiotomy syndrome (PPS) was made. Following a course of oral prednisolone, serial blood test and echocardiogram showed gradual resolution of inflammation and pericardial effusion. This rarely-reported case serves as a poignant reminder to PPS after Nuss procedure as a cause of febrile massive pericardial effusion...
January 2018: Journal of Thoracic Disease
Carsten Lennerz, Manish Barman, Mahmoud Tantawy, Mark Sopher, Peter Whittaker
BACKGROUND: Atrial fibrillation occurs frequently after open-heart surgery. It is associated with increased morbidity and mortality, longer hospital stays, and increased healthcare costs. Prophylactic administration of colchicine may mitigate post-operative atrial fibrillation (POAF). METHODS: We searched PubMed, and CENTRAL databases to identify randomized controlled trials (RCTs) that; (1) compared prophylactic use of colchicine to placebo, or usual care, in patients with sinus rhythm who underwent elective open-heart surgery and (2) reported POAF-incidence...
December 15, 2017: International Journal of Cardiology
Dirk van Osch, Hendrik M Nathoe, Kirolos A Jacob, Pieter A Doevendans, Diederik van Dijk, Willem J Suyker, Jan M Dieleman
BACKGROUND: Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the syndrome. The aim of this study was to provide an overview of existing literature around determinants of PPS in adult cardiac surgery patients. MATERIAL AND METHODS: Two independent investigators performed a systematic search in MEDLINE, EMBASE and the Cochrane Central Register...
June 2017: European Journal of Clinical Investigation
Balaji K Tamarappoo, Allan L Klein
Post-pericardiotomy syndrome (PPS) occurs in a subgroup of patients who have undergone cardiothoracic surgery and is characterized by fever, pleuritic pain, pleural effusion, and pericardial effusion. It is associated with significant morbidity, and the leading complications include tamponade and constrictive pericarditis. Epidemiologic studies have found that PPS often occurs among younger patients; however, there is a lack of comprehensive risk stratification. It is therefore important to be able to identify patients who are at high risk for developing this disease...
November 2016: Current Cardiology Reports
Nikolaos Papageorgiou, Alexandros Briasoulis, George Lazaros, Massimo Imazio, Dimitris Tousoulis
AIMS: Colchicine has been suggested to be beneficial in preventing recurrent pericarditis. The goal of this study was to review all randomized controlled trials that assess the use of colchicine for the prevention and treatment of cardiac diseases. METHODS: We performed a meta-analysis of the effects of colchicine on pericarditis, postpericardiotomy syndrome and postprocedural atrial fibrillation recurrence, in-stent restenosis, gastrointestinal adverse effects, and treatment discontinuation rates...
February 2017: Cardiovascular Therapeutics
Syed Raza Shah, Richard Alweis, Syed Arbab Shah, Mohammad Hussham Arshad, Adil Al-Karim Manji, Arham Amir Arfeen, Maheen Javed, Syed Muhammad Shujauddin, Rida Irfan, Sakina Shabbir, Shehryar Shaikh
Colchicine, extracted from the colchicum autumnale plant, used by the ancient Greeks more than 20 centuries ago, is one of the most ancient drugs still prescribed even today. The major mechanism of action is binding to microtubules thereby interfering with mitosis and subsequent modulation of polymorphonuclear leukocyte function. Colchicine has long been of interest in the treatment of cardiovascular disease; however, its efficacy and safety profile for specific conditions have been variably established in the literature...
2016: Journal of Community Hospital Internal Medicine Perspectives
U Sevuk, A Bilgic, R Altindag, E Baysal, B Yaylak, M S Adiyaman, S Akkaya, N Ay, V Alp
OBJECTIVE: Post-pericardiotomy syndrome (PPS) occurs in 10-40% of patients after cardiac surgery. PPS is considered an autoimmune phenomenon. The neutrophil-to-lymphocyte ratio (NLR) is a novel inflammatory marker that is associated with various cardiovascular diseases. Studies have reported that the NLR increases in certain autoimmune diseases. This study examined whether the NLR is helpful to predict the occurrence of PPS after elective on-pump coronary artery bypass graft (CABG) surgery...
March 2016: European Review for Medical and Pharmacological Sciences
Y-L Li, S-B Qiao, J-Y Wang, Y-M Chen, J Luo, H-F Zhang
BACKGROUND: Randomized controlled trials (RCTs) have investigated the use of colchicine and conventional therapy for reducing the recurrence of pericarditis in patients with acute pericarditis or post-pericardiotomy syndrome. However, the benefits of these treatments are variable. METHODS: Studies were retrieved from PubMed, the Cochrane Library, and the EMBASE database. RESULTS: We identified nine RCTs with 1832 patients and a mean follow-up of 13...
November 2016: Herz
Kazim Ergunes, Hasan Iner, Ismail Yurekli, Orhan Gokalp, Ufuk Yetkin, Ali Gurbuz
No abstract text is available yet for this article.
December 16, 2015: Journal of Cardiothoracic Surgery
Feridoun Sabzi, Reza Faraji
INTRODUCTION: Pathological involvement of pericardium by any disease that resulting in effusion may require decompression and pericardiectomy. The current article describes rare patients with effusion who after pericadiectomy and transient hemodynamic improvement rapidly developed progressive heart failure and subsequent multi organ failure. METHODS: During periods of five years, 423 patients in our hospital underwent pericardiotomy for decompression of effusion...
2015: Journal of Cardiovascular and Thoracic Research
Paola Casanova, Rosa T Artola, Christos G Mihos, Andres M Pineda, Orlando Santana
Colchicine is used extensively in the treatment of autoimmune and inflammatory disorders. Recent data have demonstrated additional benefit in a variety of cardiovascular disorders, including acute and recurrent pericarditis, postpericardiotomy syndrome, atrial fibrillation, stable ischemic heart disease, and possibly chronic heart failure. This article serves as a focused and updated discussion on the cardiovascular effects of colchicine and emphasizes the importance of randomized, placebo-controlled trials to further our clinical and pharmacological understanding of these findings...
November 2015: Cardiology in Review
Arvind Kalyan Sundaram, Patrick Gordan, Robert Campbell, Vladamir Birjinuik
SESSION TITLE: Pleural Student/Resident Case Report PostersSESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Post-pericardiotomy syndrome (PPS) is a common complication following cardio-thoracic surgery (CTS). Studies have shown Colchicine to be effective for the prevention of PPS. Although available, there are less data for the treatment of PPS with Colchicine. We present a case of a patient diagnosed with PPS who had persistent symptoms necessitating treatment with Colchicine...
October 1, 2014: Chest
M Chadi Alraies, Wael AlJaroudi, Cyrus Shabrang, Hirad Yarmohammadi, Allan L Klein, Balaji K Tamarappoo
Postpericardiotomy syndrome (PPS) may be associated with tamponade and pericardial constriction that may require procedural intervention. The aim of this study was to identify clinical features associated with adverse events requiring procedural intervention in patients with PPS. A total of 239 patients who developed PPS after cardiac surgery were monitored for 12 months. PPS was diagnosed if 2 of the 5 following findings were present: fever without infection, pleuritic pain, friction rub, pleural effusion, and pericardial effusion (<60 days after surgery)...
November 1, 2014: American Journal of Cardiology
Howard J Heching, Emile A Bacha, Leonardo Liberman
Surgical repair for atrial septal defects (ASD) generally occurs during childhood. Post-pericardiotomy syndrome (PPS) after cardiac surgery has a reported incidence of 1-40 %. We focused exclusively on secundum ASD repair to evaluate the incidence of PPS. The purpose of this study is to determine the incidence of PPS after surgical repair of secundum ASD and investigate what risk factors may be predictive of its development. A retrospective study was performed, and 97 patients who underwent surgical closure of a secundum ASD were identified...
March 2015: Pediatric Cardiology
No abstract text is available yet for this article.
1964: A Listing of Research in the Cardiovascular Field
Massimo Imazio, Riccardo Belli, Antonio Brucato, Paolo Ferrazzi, Davide Patrini, Luigi Martinelli, Vincenzo Polizzi, Roberto Cemin, Anna Leggieri, Alida L P Caforio, Yaron Finkelstein, Brian Hoit, Bernhard Maisch, Bongani M Mayosi, Jae K Oh, Arsen D Ristic, Petar Seferovic, David H Spodick, Yehuda Adler
BACKGROUND: The efficacy and safety of colchicine for the primary prevention of the postpericardiotomy syndrome (PPS), postoperative effusions, and postoperative atrial fibrillation (POAF) remain uncertain. Although preliminary data from a single trial of colchicine given for 1 month postoperatively (COPPS trial) were promising, the results have not been confirmed in a large, multicenter trial. Moreover, in the COPPS trial, colchicine was given 3 days postoperatively. METHODS: The COPPS-2 study is a multicenter, double-blind, placebo-controlled randomized trial...
July 2013: American Heart Journal
Stefano Salizzoni, Michele La Torre, Cristina Barbero, Walter Grosso Marra, Claudio Moretti, Maurizio D'Amico, Mauro Rinaldi
A 60 year-old female underwent tricuspid valve replacement in 2002. Post-operative recovery was complicated by severe post-pericardiotomy-syndrome. Seven years later she underwent transcatheter valve-in-valve implantation through the right jugular vein because of early prosthesis deterioration. Moreover intra-operative transoesophageal echocardiography showed an important right-to-left shunt through the patent foramen ovale that immediately disappeared after the deployment of a 29-mm Sapien-XT. The patient had an immediate and dramatic improvement in day-by-day activities...
December 2013: Heart, Lung & Circulation
Massimo Imazio, Brian D Hoit
The term "post-cardiac injury syndromes" includes post-myocardial infarction pericarditis, post-pericardiotomy syndrome, and post-traumatic pericarditis (iatrogenic, i.e. after percutaneous coronary or intracardiac interventions, such as pacemaker lead insertion, radiofrequency ablation, or non-iatrogenic, i.e. following blunt or penetrating trauma). All these conditions represent different clinical conditions characterized by an initial cardiac injury involving the pericardium/myocardium and/or pleura and the subsequent inflammatory syndrome ranging from simple, uncomplicated pericarditis to more complicated cases with pleuropericarditis, cardiac tamponade or massive pleural effusion...
September 30, 2013: International Journal of Cardiology
Massimo Imazio, Antonio Brucato, Paolo Ferrazzi, David H Spodick, Yehuda Adler
The post-pericardiotomy syndrome (PPS) affects 10-40% of patients after cardiac surgery, depending on the adopted diagnostic criteria, institution and type of surgery. On this basis, there is a need for standardized criteria for epidemiological and clinical purposes, which we propose on the basis of the largest published clinical trials on PPS prevention. Proposed diagnostic criteria for the PPS include: fever without alternative causes, pleuritic chest pain, friction rub, evidence of new or worsening pleural effusion, and evidence of new or worsening pericardial effusion...
May 2013: Journal of Cardiovascular Medicine
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