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https://www.readbyqxmd.com/read/27908594/rucaparib-in-relapsed-platinum-sensitive-high-grade-ovarian-carcinoma-ariel2-part-1-an-international-multicentre-open-label-phase-2-trial
#1
Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, Anne Floquet, Alexandra Leary, Thomas C Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A McNeish
BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous recombination deficiency. In ARIEL2, we assessed the ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor. METHODS: ARIEL2 is an international, multicentre, two-part, phase 2, open-label study done at 49 hospitals and cancer centres in Australia, Canada, France, Spain, the UK, and the USA...
November 28, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27829474/untrained-consumer-assessment-of-the-eating-quality-of-beef-1-a-single-composite-score-can-predict-beef-quality-grades
#2
S P F Bonny, J-F Hocquette, D W Pethick, I Legrand, J Wierzbicki, P Allen, L J Farmer, R J Polkinghorne, G E Gardner
Quantifying consumer responses to beef across a broad range of demographics, nationalities and cooking methods is vitally important for any system evaluating beef eating quality. On the basis of previous work, it was expected that consumer scores would be highly accurate in determining quality grades for beef, thereby providing evidence that such a technique could be used to form the basis of and eating quality grading system for beef. Following the Australian MSA (Meat Standards Australia) testing protocols, over 19 000 consumers from Northern Ireland, Poland, Ireland, France and Australia tasted cooked beef samples, then allocated them to a quality grade; unsatisfactory, good-every-day, better-than-every-day and premium...
November 10, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27760342/antiviral-cd8-t-cells-restricted-by-human-leukocyte-antigen-class-ii-exist-during-natural-hiv-infection-and-exhibit-clonal-expansion
#3
Srinika Ranasinghe, Pedro A Lamothe, Damien Z Soghoian, Samuel W Kazer, Michael B Cole, Alex K Shalek, Nir Yosef, R Brad Jones, Faith Donaghey, Chioma Nwonu, Priya Jani, Gina M Clayton, Frances Crawford, Janice White, Alana Montoya, Karen Power, Todd M Allen, Hendrik Streeck, Daniel E Kaufmann, Louis J Picker, John W Kappler, Bruce D Walker
CD8(+) T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8(+) T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8(+) T cells underwent clonal expansion and mediated killing of HIV-infected cells...
October 18, 2016: Immunity
https://www.readbyqxmd.com/read/27754716/storage-of-unfed-and-leftover-pasteurized-human-milk
#4
Ting Meng, Maryanne T Perrin, Jonathan C Allen, Jason Osborne, Frances Jones, April D Fogleman
OBJECTIVE: To determine the impact of storage on bacterial growth and immunological activity of pasteurized human milk and leftover pasteurized human milk that has been exposed to the microflora in an infant's mouth. MATERIALS AND METHODS: Eighteen mother-infant dyads participated in two separate studies. Mother's milk was pasteurized, and each baby was fed 1 to 2 ounces. Pasteurized and leftover pasteurized milk were stored at room (24°C) and refrigerated temperatures (4°C)...
October 18, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27575290/assessment-of-maximum-aerobic-capacity-and-anaerobic-threshold-of-elite-ballet-dancers
#5
Matthew A Wyon, Nick Allen, Ross Cloak, Sarah Beck, Paul Davies, Frances Clarke
An athlete's cardiorespiratory profile, maximal aerobic capacity, and anaerobic threshold is affected by training regimen and competition demands. The present study aimed to ascertain whether there are company rank differences in maximal aerobic capacity and anaerobic threshold in elite classical ballet dancers. Seventy-four volunteers (M 34, F 40) were recruited from two full-time professional classical ballet companies. All participants completed a continuous incremental treadmill protocol with a 1-km/hr speed increase at the end of each 1-min stage until termination criteria had been achieved (e...
September 2016: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/27565168/the-impact-of-interventions-that-integrate-accelerometers-on-physical-activity-and-weight-loss-a-systematic-review
#6
Adam P Goode, Katherine S Hall, Bryan C Batch, Kim M Huffman, S Nicole Hastings, Kelli D Allen, Ryan J Shaw, Frances A Kanach, Jennifer R McDuffie, Andrzej S Kosinski, John W Williams, Jennifer M Gierisch
BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitors) may be a promising, scalable strategy to increase physical activity or decrease weight. PURPOSE: We synthesized the literature on the use of wearable activity monitors for improving physical activity and weight-related outcomes and evaluated moderating factors that may have an impact on effectiveness...
August 26, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27549362/redesigning-a-participatory-health-study-for-a-french-industrial-context
#7
Barbara L Allen, Alison K Cohen, Yolaine Ferrier, Johanna Lees, Travis Richards
The Marseille, France, metropolitan area is home to a heavily concentrated industrial region directly adjacent to residential communities. These towns have been subjected to a wide variety of social science and public health studies, but residents continue to have many questions about health concerns for which they currently have primarily anecdotal evidence. Reflecting on our in-progress research in two of these towns, we argue that community-based participatory research that draws from both social science and public health science can be successfully adapted to the French political and cultural context and is key for developing environmental health research that is relevant for community residents and local leaders...
August 21, 2016: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/27501300/nanoimprint-of-a-3d-structure-on-an-optical-fiber-for-light-wavefront-manipulation
#8
Giuseppe Calafiore, Alexander Koshelev, Frances I Allen, Scott Dhuey, Simone Sassolini, Edward Wong, Paul Lum, Keiko Munechika, Stefano Cabrini
Integration of complex photonic structures onto optical fiber facets enables powerful platforms with unprecedented optical functionalities. Conventional nanofabrication technologies, however, do not permit viable integration of complex photonic devices onto optical fibers owing to their low throughput and high cost. In this paper we report the fabrication of a three-dimensional structure achieved by direct nanoimprint lithography on the facet of an optical fiber. Nanoimprint processes and tools were specifically developed to enable a high lithographic accuracy and coaxial alignment of the optical device with respect to the fiber core...
September 16, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27472584/high-refractive-index-fresnel-lens-on-a-fiber-fabricated-by-nanoimprint-lithography-for-immersion-applications
#9
Alexander Koshelev, Giuseppe Calafiore, Carlos Piña-Hernandez, Frances I Allen, Scott Dhuey, Simone Sassolini, Edward Wong, Paul Lum, Keiko Munechika, Stefano Cabrini
In this Letter, we present a Fresnel lens fabricated on the end of an optical fiber. The lens is fabricated using nanoimprint lithography of a functional high refractive index material, which is suitable for mass production. The main advantage of the presented Fresnel lens compared to a conventional fiber lens is its high refractive index (n=1.68), which enables efficient light focusing even inside other media, such as water or an adhesive. Measurement of the lens performance in an immersion liquid (n=1.51) shows a near diffraction limited focal spot of 810 nm in diameter at the 1/e<sup>2</sup> intensity level for a wavelength of 660 nm...
August 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27468268/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy
#10
REVIEW
Ernest M Graham, Irina Burd, Allen D Everett, Frances J Northington
Recent research in identification of brain injury after trauma shows many possible blood biomarkers that may help identify the fetus and neonate with encephalopathy. Traumatic brain injury shares many common features with perinatal hypoxic-ischemic encephalopathy. Trauma has a hypoxic component, and one of the 1st physiologic consequences of moderate-severe traumatic brain injury is apnea. Trauma and hypoxia-ischemia initiate an excitotoxic cascade and free radical injury followed by the inflammatory cascade, producing injury in neurons, glial cells and white matter...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27363352/aot-and-long-term-use-of-antipsychotics-2
#11
Allen Frances, Ronald W Pies
No abstract text is available yet for this article.
July 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27354481/nivolumab-in-combination-with-platinum-based-doublet-chemotherapy-for-first-line-treatment-of-advanced-non-small-cell-lung-cancer
#12
Naiyer A Rizvi, Matthew D Hellmann, Julie R Brahmer, Rosalyn A Juergens, Hossein Borghaei, Scott Gettinger, Laura Q Chow, David E Gerber, Scott A Laurie, Jonathan W Goldman, Frances A Shepherd, Allen C Chen, Yun Shen, Faith E Nathan, Christopher T Harbison, Scott Antonia
PURPOSE: Nivolumab, a fully human immunoglobulin G4 programmed death-1 immune checkpoint inhibitor antibody, has demonstrated improved survival in previously treated patients with advanced non-small-cell lung cancer (NSCLC). CheckMate 012, a phase I, multicohort study, was conducted to explore the safety and efficacy of nivolumab as monotherapy or combined with current standard therapies in first-line advanced NSCLC. Here, we report results for nivolumab plus platinum-based doublet chemotherapy (PT-DC)...
September 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27345555/-multidisciplinary-management-of-children-with-disabling-chronic-pain-in-a-french-pediatric-rehabilitation-center-current-management-and-perspectives
#13
N Roessler, C Allen Debeaurepaire, A Deprez, L Tanche, V Pavageau, A Hamain, C Grave, A Yatzimirsky, L Vallée, J Avez-Couturier
INTRODUCTION: Chronic pain in children and adolescents has a major impact on their life in terms of school, sleep as well as family and social life. Teenagers aged 13-15 and girls are at the highest risk. Zeltzer et al. established a bio-psychosocial model of chronic pain in 1998 to account for all its dimensions and advocated a multidisciplinary management plan. Programs based on their principles target specific symptoms such as anxiety and loss of function, while treating underlying factors and teaching coping skills to patients and their families...
August 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27323536/-allen-masters-syndrome-as-a-cause-for-chronic-pelvic-pain-diagnosis-treatment-and-long-term-follow-up
#14
Naama Marcus Braun, Inbar Ben Shachar
Chronic pelvic pain is one of the main causes for repeated ambulatory and hospital visits. The main findings on exploratory laparoscopy performed for these complaints are endometriosis and adhesions, while in more than 50% of cases, no cause for the pain is found. In 1955, Allen and Masters reported pain associated with traumatic labor. They reported retroverted and hyper-mobile uterus in all women and during operation, tears in the posterior serosa of the broad igament. A few therapeutic options have been discussed, including repair of the tears, but without long term follow-up and significant relief of symptoms...
April 2016: Harefuah
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#15
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27301783/advances-in-implantable-bionic-devices-for-blindness-a-review
#16
REVIEW
Philip M Lewis, Lauren N Ayton, Robyn H Guymer, Arthur J Lowery, Peter J Blamey, Penelope J Allen, Chi D Luu, Jeffrey V Rosenfeld
Since the 1950s, vision researchers have been working towards the ambitious goal of restoring a functional level of vision to the blind via electrical stimulation of the visual pathways. Groups based in Australia, USA, Germany, France and Japan report progress in the translation of retinal visual prosthetics from the experimental to clinical domains, with two retinal visual prostheses having recently received regulatory approval for clinical use. Regulatory approval for cortical visual prostheses is yet to be obtained; however, several groups report plans to conduct clinical trials in the near future, building upon the seminal clinical studies of Brindley and Dobelle...
September 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27280183/robert-spitzer-the-most-influential-psychiatrist-of-his-time
#17
Allen Frances
No abstract text is available yet for this article.
February 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27271867/phase-ii-study-to-evaluate-the-safety-and-efficacy-of-intravenous-palonosetron-pal-in-primary-malignant-glioma-mg-patients-receiving-standard-radiotherapy-rt-and-concomitant-temozolomide-tmz
#18
Mary Lou Affronti, Sarah Woodring, Karen Allen, John Kirkpatrick, Katherine B Peters, James E Herndon, Frances McSherry, Patrick N Healy, Annick Desjardins, James J Vredenburgh, Henry S Friedman
BACKGROUND: In malignant glioma (MG) patients undergoing radiation therapy (RT) with concomitant temozolomide, chemoradiation-induced nausea and vomiting (cRINV) degrades quality of life (QoL) and reduces treatment adherence, which thereby potentially compromises cancer control. METHODS: We conducted a 6-week phase II single-arm trial of PAL, a second-generation 5-HT3RA antiemetic, for cRINV prevention in MG patients receiving radiation therapy (RT; 54-60 Gy) and concomitant daily temozolomide (TMZ; 75 mg/m(2)/dX42d)...
October 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27256090/risk-factors-for-dermatitis-in-submariners-during-a-submerged-patrol-an-observational-cohort-study
#19
Amy Flaxman, Elizabeth Allen, Claudia Lindemann, Yuko Yamaguchi, Matthew K O'Shea, Joanne L Fallowfield, Michael Lindsay, Frances Gunner, Kyle Knox, David H Wyllie
OBJECTIVE: The aim of this pilot study was to determine risk factors, including Staphylococcus aureus nasal carriage, for dermatitis in submariners during a submarine patrol. PARTICIPANTS AND METHODS: 36 submariners undertaking a submerged 6-week patrol participated in the study. Severity of dermatitis and its impact was assessed using visual analogue scales and questionnaires at baseline and weekly throughout the patrol. S. aureus carriage levels in submariners were determined by nasal swabbing at baseline and shortly before disembarking the submarine...
2016: BMJ Open
https://www.readbyqxmd.com/read/27088349/differences-in-genotype-clinical-features-and-inflammatory-potential-of-borrelia-burgdorferi-sensu-stricto-strains-from-europe-and-the-united-states
#20
Tjasa Cerar, Franc Strle, Dasa Stupica, Eva Ruzic-Sabljic, Gail McHugh, Allen C Steere, Klemen Strle
Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential. Analysis of outer surface protein C and multilocus sequence typing showed that strains from these 2 regions represent distinct genotypes. Clinical features of infection with B. burgdorferi in Slovenia were similar to infection with B. afzelii or B. garinii, the other 2 Borrelia spp. that cause disease in Europe, whereas B...
May 2016: Emerging Infectious Diseases
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