Adam S Kittai, David Bond, Ying Huang, Seema A Bhat, Emily Blyth, John C Byrd, Julio C Chavez, Matthew S Davids, Jamie P Dela Cruz, Mark R Dowling, Caitlyn Duffy, Carrie Ho, Caron Jacobson, Samantha Jaglowski, Nitin Jain, Kevin H Lin, Cecelia Miller, Christine McCarthy, Zulfa Omer, Erin Parry, Manoj Rai, Kerry A Rogers, Aditi Saha, Levanto Schachter, Hamish Scott, Jayastu Senapati, Mazyar Shadman, Tanya Siddiqi, Deborah M Stephens, Vinay Vanguru, William Wierda, Jennifer A Woyach, Philip A Thompson
PURPOSE: Outcomes for Richter transformation (RT) are poor with current therapies. The efficacy and safety of anti-CD19 chimeric antigen receptor T-cell therapy (CAR-T) for RT are not established. METHODS: We performed an international multicenter retrospective study of patients with RT who received CAR-T. Patient, disease, and treatment characteristics were summarized using descriptive statistics, and modeling analyses were used to determine association with progression-free survival (PFS) and overall survival (OS)...
March 29, 2024: Journal of Clinical Oncology