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https://www.readbyqxmd.com/read/28547853/the-efficacy-of-high-density-spinal-cord-stimulation-among-trial-implant-and-conversion-patients-a-retrospective-case-series
#1
David A Provenzano, Jared Rebman, Cody Kuhel, Hilary Trenz, Jason Kilgore
OBJECTIVES: Methods of energy delivery for traditional spinal cord stimulation (SCS) systems consist of adjusting programming parameters to affect the total charge delivered per unit time. One high electrical charge delivery method being considered is subthreshold high density (HD) programming. To date, there is limited clinical evidence for the efficacy and safety of paresthesia-free HD programming. The aim of this study was to examine the efficacy and safety of HD programming. MATERIALS AND METHODS: A retrospective review was performed on HD-programmed SCS patients with a minimum of one year follow-up...
May 25, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28544732/similar-familial-underpinnings-for-full-and-subsyndromal-pediatric-bipolar-disorder-a-familial-risk-analysis
#2
Janet Wozniak, Mai Uchida, Stephen V Faraone, Maura Fitzgerald, Carrie Vaudreuil, Nicholas Carrellas, Jacqueline Davis, Rebecca Wolenski, Joseph Biederman
OBJECTIVES: To examine the validity of subthreshold pediatric bipolar I disorder (BP-I), we compared the familial risk for BP-I in the child probands who had either full BP-I, subthreshold BP-I, ADHD, or were controls that neither had ADHD nor bipolar disorder. METHODS: BP-I probands were youth aged 6-17 years meeting criteria for BP-I, full (N=239) or subthreshold (N=43), and also included were their first-degree relatives (N=687 and N=120, respectively). Comparators were youth with ADHD (N=162), controls without ADHD or bipolar disorder (N=136), and their first-degree relatives (N=511 and N=411, respectively)...
May 22, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28542780/baseline-dimensional-psychopathology-and-future-mood-disorder-onset-findings-from-the-dutch-bipolar-offspring-study
#3
E Mesman, W A Nolen, L Keijsers, M H J Hillegers
OBJECTIVE: To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD. METHOD: The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12- year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores...
May 20, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28541768/sex-differences-in-the-presentation-of-body-dysmorphic-disorder-in-a-community-sample-of-adolescents
#4
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The current study sought to explore sex differences in the presentation of probable full-syndrome and subthreshold body dysmorphic disorder (BDD) in adolescents from an Australian community sample. Specifically, it examined sex differences in the types of BDD symptoms endorsed, body areas of concern, and the association with elevated symptoms of comorbid disorders. In male participants, it also compared the presenting features of those with and without muscle dysmorphia. Of 3,149 adolescents assessed using self-report questionnaires, 162 (5...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28540655/a-review-of-subthreshold-micropulse-laser-for-treatment-of-macular-disorders
#5
REVIEW
Paula Scholz, Lebriz Altay, Sascha Fauser
Micropulse laser treatment is an alternative to the conventional continuous-wave laser for the treatment of retinal or macular diseases. In contrast to the conventional laser, the therapeutic effect of the subthreshold micropulse laser is not accompanied by thermal retinal damage. This fact is of particular importance when a treatment near the fovea is required. Micropulse treatment is applied in indications such as central serous chorioretinopathy (CSC), diabetic macular edema (DME), or macular edema due to retinal vein occlusion (RVO)...
May 24, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28539950/association-of-changes-in-mood-status-and-psychosocial-well-being-with-depression-during-interferon-based-treatment-for-hepatitis-c
#6
Jung-Seok Choi, Won Kim, Bo Kyung Sohn, Jun-Young Lee, Hee Yeon Jung, Sohee Oh, Sae Kyoung Joo, Hwi Young Kim, Yong Jin Jung
OBJECTIVE: The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression. METHODS: CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28532252/chronic-subthreshold-cortical-stimulation-a-therapeutic-and-potentially-restorative-therapy-for-focal-epilepsy
#7
Brian Nils Lundstrom, Gregory A Worrell, Matt Stead, Jamie J Van Gompel
Approximately one third of patients with focal epilepsy continue to have ongoing seizures despite adequate trials of anti-seizure medications. Surgery to remove the epileptogenic zone remains the most efficacious treatment option for focal drug-resistant epilepsy. However, when cortical areas are eloquent or there are multiple epileptogenic zones, surgical resection is not an ideal approach. Cortical stimulation provides an attractive alternative. Area Covered: Here, the authors describe Chronic Subthreshold Cortical Stimulation (CSCS), which uses continuous intracranial electrical stimulation applied near the epileptogenic zone to lower seizure probability...
May 22, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28529361/prevalence-and-correlates-of-obsessive-compulsive-disorder-and-subthreshold-obsessive-compulsive-disorder-among-college-students-in-kerala-india
#8
T S Jaisoorya, Y C Janardhan Reddy, B Sivasankaran Nair, Anjana Rani, Priya G Menon, M Revamma, C R Jeevan, K S Radhakrishnan, Vineetha Jose, K Thennarasu
CONTEXT: There are scarce data on the prevalence of adult obsessive-compulsive disorder (OCD) in India. AIMS: The aim was to study the point prevalence of OCD and subthreshold OCD and its psychosocial correlates among college students in the district of Ernakulam, Kerala, India. SETTINGS AND DESIGN: A cross-sectional survey of 5784 students of the age range of 18-25 years from 58 colleges was conducted. MATERIALS AND METHODS: Students were self-administered the OCD subsection of the Clinical Interview Schedule-Revised, the Composite International Diagnostic Interview for obsessive-compulsive symptoms (OCSs), and other relevant instruments to identify OCD, subthreshold OCD, and related clinical measures...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28523281/imaging-membrane-potential-changes-from-dendritic-spines-using-computer-generated-holography
#9
Dimitrii Tanese, Ju-Yun Weng, Valeria Zampini, Vincent De Sars, Marco Canepari, Balazs Rozsa, Valentina Emiliani, Dejan Zecevic
Electrical properties of neuronal processes are extraordinarily complex, dynamic, and, in the general case, impossible to predict in the absence of detailed measurements. To obtain such a measurement one would, ideally, like to be able to monitor electrical subthreshold events as they travel from synapses on distal dendrites and summate at particular locations to initiate action potentials. It is now possible to carry out these measurements at the scale of individual dendritic spines using voltage imaging. In these measurements, the voltage-sensitive probes can be thought of as transmembrane voltmeters with a linear scale, which directly monitor electrical signals...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28521253/differences-in-cognitive-deficits-in-individuals-with-subthreshold-syndromes-with-and-without-family-history-of-bipolar-disorder
#10
Kangguang Lin, Rui Lu, Kun Chen, Ting Li, Weicong Lu, Jiehua Kong, Guiyun Xu
Little is known about the development of cognitive deficits prior to the official onset of bipolar disorder (BP). The aim of this study was to investigate neurocognitive performance in two early stages of BP. This high-risk design study recruited a group of offspring of parents with BP (n = 58), aged 8-28 years. Based on the subthreshold syndromes, the "unaffected" offspring were further divided into high-risk (HR) and ultra-high-risk (UHR) stages. For comparison, a group of individuals with subthreshold symptoms but without family history of psychiatric disorder (n = 17) and 48 healthy controls (HCs) were included...
May 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28516509/the-incidence-and-predictors-of-depressive-and-anxiety-symptoms-in-older-adults-with-vision-impairment-a-longitudinal-prospective-cohort-study
#11
Thomas J Heesterbeek, Hilde P A van der Aa, Ger H M B van Rens, Johannes W R Twisk, Ruth M A van Nispen
PURPOSE: Depression and anxiety are highly prevalent in older adults with vision impairment. Because symptoms of depression and anxiety appear to fluctuate, it is important to identify patients who are at risk of developing these symptoms for early diagnosis and treatment. Therefore, the aim of this study was to determine the incidence of subthreshold depression and anxiety, and to investigate predictors of developing symptoms of depression and anxiety in older adults with vision impairment who had no subthreshold depression or anxiety at baseline...
May 18, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#12
S Kasper, W E Müller, H P Volz, H J Möller, E Koch, A Dienel
OBJECTIVE: Silexan is a lavender oil preparation available in capsules containing 80 mg. Here we review clinical trials investigating its anxiolytic efficacy, safety, and tolerability in humans as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
May 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28509901/a-continuum-of-genetic-liability-for-minor-and-major-depression
#13
E C Corfield, Y Yang, N G Martin, D R Nyholt
The recent success of a large genome-wide association (GWA) study-analysing 130 620 major depression cases and 347 620 controls-in identifying the first single-nucleotide polymorphism (SNP) loci robustly associated with major depression in Europeans confirms that immense sample sizes are required to identify risk loci for depression. Given the phenotypic similarity between major depressive disorder (MDD) and the less severe minor depressive disorder (MiDD), we hypothesised that broadening the case definition to include MiDD may be an efficient approach to increase sample sizes in GWA studies of depression...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28499900/lurasidone-in-post-menopausal-females-with-major-depressive-disorder-with-mixed-features-post-hoc-analysis-of-a-placebo-controlled-trial
#14
John Sramek, Anthony Loebel, Michael Murphy, Yongcai Mao, Andrei Pikalov, Neal R Cutler
BACKGROUND: Several studies have found that depressed, post-menopausal females may respond differently to antidepressants compared to pre-menopausal females. The atypical antipsychotic lurasidone, whose mechanism of action differs from SSRIs and other standard antidepressants, was shown in a 6-week randomized, flexible-dose, placebo-controlled study (n=209), to be effective in treating major depressive disorder (MDD) with mixed features (subthreshold hypomanic symptoms). This post-hoc analysis assessed the efficacy of lurasidone in this study by menopausal status...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28494965/multiscale-determinants-of-delayed-afterdepolarization-amplitude-in-cardiac-tissue
#15
Christopher Y Ko, Michael B Liu, Zhen Song, Zhilin Qu, James N Weiss
Spontaneous calcium (Ca) waves in cardiac myocytes underlie delayed afterdepolarizations (DADs) that trigger cardiac arrhythmias. How these subcellular/cellular events overcome source-sink factors in cardiac tissue to generate DADs of sufficient amplitude to trigger action potentials is not fully understood. Here, we evaluate quantitatively how factors at the subcellular scale (number of Ca wave initiation sites), cellular scale (sarcoplasmic reticulum (SR) Ca load), and tissue scale (synchrony of Ca release in populations of myocytes) determine DAD features in cardiac tissue using a combined experimental and computational modeling approach...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28494802/reducing-depressive-symptomatology-with-a-smartphone-app-study-protocol-for-a-randomized-placebo-controlled-trial
#16
Cezar Giosan, Oana Cobeanu, Cristina Mogoaşe, Aurora Szentagotai, Vlad Mureşan, Rareș Boian
BACKGROUND: Depression has become one of the leading contributors to the global disease burden. Evidence-based treatments for depression are available, but access to them is still limited in some instances. As technology has become more integrated into mental health care, computerized cognitive behavioral therapy (CBT) protocols have become available and have been recently transposed to mobile environments (e.g., smartphones) in the form of "apps." Preliminary research on some depression apps has shown promising results in reducing subthreshold or mild to moderate depressive symptoms...
May 12, 2017: Trials
https://www.readbyqxmd.com/read/28494570/investigation-of-bulk-traps-by-conductance-method-in-the-deep-depletion-region-of-the-al2o3-gan-mos-device
#17
Yuanyuan Shi, Qi Zhou, Anbang Zhang, Liyang Zhu, Yu Shi, Wanjun Chen, Zhaoji Li, Bo Zhang
Conductance method was employed to study the physics of traps (e.g., interface and bulk traps) in the Al2O3/GaN MOS devices. By featuring only one single peak in the parallel conductance (G p/ω) characteristics in the deep depletion region, one single-level bulk trap (E C-0.53 eV) uniformly distributed in GaN buffer was identified. While in the subthreshold region, the interface traps with continuous energy of E C-0.4~0.57 eV and density of 0.6~1.6 × 10(12) cm(-2) were extracted from the commonly observed multiple G p/ω peaks...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#18
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28490022/concurrent-treatment-with-prolonged-exposure-for-co-occurring-full-or-subthreshold-posttraumatic-stress-disorder-and-substance-use-disorders-a-randomized-clinical-trial
#19
Lesia M Ruglass, Teresa Lopez-Castro, Santiago Papini, Therese Killeen, Sudie E Back, Denise A Hien
BACKGROUND: To test whether an integrated prolonged exposure (PE) approach could address posttraumatic stress disorder (PTSD) symptoms effectively in individuals with co-occurring substance use disorders (SUD), we compared concurrent treatment of PTSD and SUD using PE (COPE) to relapse prevention therapy (RPT) for SUD and an active monitoring control group (AMCG). METHODS: We conducted a randomized 12-week trial with participants (n = 110; 64% males; 59% African Americans) who met Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for full or subthreshold PTSD and SUD...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28489103/triethanolamine-doped-multilayer-mos2-field-effect-transistors
#20
Min-Yeul Ryu, Ho-Kyun Jang, Kook Jin Lee, Mingxing Piao, Seung-Pil Ko, Minju Shin, Junghwan Huh, Gyu-Tae Kim
Chemical doping has been investigated as an alternative method of conventional ion implantation for two-dimensional materials. We herein report chemically doped multilayer molybdenum disulfide (MoS2) field effect transistors (FETs) through n-type channel doping, wherein triethanolamine (TEOA) is used as an n-type dopant. As a result of the TEOA doping process, the electrical performances of multilayer MoS2 FETs were enhanced at room temperature. Extracted field effect mobility was estimated to be ∼30 cm(2) V(-1) s(-1) after the surface doping process, which is 10 times higher than that of the pristine device...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
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