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https://www.readbyqxmd.com/read/28808978/the-role-of-negative-conductances-in-neuronal-subthreshold-properties-and-synaptic-integration
#1
REVIEW
Cesar C Ceballos, Antonio C Roque, Ricardo M Leão
Based on passive cable theory, an increase in membrane conductance produces a decrease in the membrane time constant and input resistance. Unlike the classical leak currents, voltage-dependent currents have a nonlinear behavior which can create regions of negative conductance, despite the increase in membrane conductance (permeability). This negative conductance opposes the effects of the passive membrane conductance on the membrane input resistance and time constant, increasing their values and thereby substantially affecting the amplitude and time course of postsynaptic potentials at the voltage range of the negative conductance...
August 14, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28802901/effect-of-vertical-sleeve-gastrectomy-on-alcohol-consumption-and-preferences-in-dietary-obese-rats-and-mice-a-plausible-role-for-altered-ghrelin-signaling
#2
Elise R Orellana, Catherine Jamis, Nelli Horvath, Andras Hajnal
Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most common surgical options for the treatment of obesity and metabolic disorder. Whereas RYGB may result in greater and more durable weight loss, recent clinical and pre-clinical studies in rats have raised concerns that RYGB surgery may increase risk for alcohol use disorder (AUD). In contrast, recent clinical reports suggest a lesser risk for AUD following VSG, although no preclinical studies have been done to confirm that. Therefore, the present study sought to determine the effects of VSG on ethanol intake and preferences in rodent models using protocols similar to those previously used in animal studies for RYGB...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28801295/-foshouningshen-decoction-improves-sleeping-via-the-serotonergic-system-in-a-rat-model-of-insomnia
#3
Jie-Cong Huang, Wei Xie, Ning Deng, Wen-Lin Liang, Dong-Rong Hu, Yu Hong, Yang Zhou
OBJECTIVE: To evaluate the sedative and hypnotic effects of Foshouningshen decoction (FSNSD) and study its effects on expressions of 5-hydroxy tryptamine (5-HT) and 5-HT1A receptor (5-HT1AR) in the hippocampus in a rat model of insomnia. METHODS: Male KM mice were divided into control group, estazolam (0.4 mg/kg daily) group, and low-, moderate-, and high-dose FSNSD groups (daily dose of 12, 24, and 48 g/kg, respectively). After corresponding treatments for 1 week, the mice underwent sleep-inducing test with subthreshold and threshold doses of sodium pentobarbital...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#4
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28790909/estimation-of-synaptic-conductances-in-presence-of-nonlinear-effects-caused-by-subthreshold-ionic-currents
#5
Catalina Vich, Rune W Berg, Antoni Guillamon, Susanne Ditlevsen
Subthreshold fluctuations in neuronal membrane potential traces contain nonlinear components, and employing nonlinear models might improve the statistical inference. We propose a new strategy to estimate synaptic conductances, which has been tested using in silico data and applied to in vivo recordings. The model is constructed to capture the nonlinearities caused by subthreshold activated currents, and the estimation procedure can discern between excitatory and inhibitory conductances using only one membrane potential trace...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28782982/sleep-continuity-architecture-and-quality-among-treatment-seeking-cannabis-users-an-in-home-unattended-polysomnographic-study
#6
Lauren R Pacek, Evan S Herrmann, Michael T Smith, Ryan Vandrey
The objective of the study was to describe self-report and objectively measured sleep characteristics of adult treatment-seeking cannabis users. Study participants (n = 87) were adults who were screened for a 12-week outpatient cannabis treatment research program in Baltimore, MD. Participants completed objective and self-report measures of sleep quality. Data were analyzed for the sample overall and after stratifying by sex (54 men, 33 women). Participants were primarily urban, socioeconomically disadvantaged African Americans...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28780051/linked-gauss-diffusion-processes-for-modeling-a-finite-size-neuronal-network
#7
M F Carfora, E Pirozzi
A Leaky Integrate-and-Fire (LIF) model with stochastic current-based linkages is considered to describe the firing activity of neurons interacting in a (2×2)-size feed-forward network. In the subthreshold regime and under the assumption that no more than one spike is exchanged between coupled neurons, the stochastic evolution of the neuronal membrane voltage is subject to random jumps due to interactions in the network. Linked Gauss-Diffusion processes are proposed to describe this dynamics and to provide estimates of the firing probability density of each neuron...
August 2, 2017: Bio Systems
https://www.readbyqxmd.com/read/28774929/chemogenetics-revealed-dreadd-occupancy-and-activation-via-converted-clozapine
#8
Juan L Gomez, Jordi Bonaventura, Wojciech Lesniak, William B Mathews, Polina Sysa-Shah, Lionel A Rodriguez, Randall J Ellis, Christopher T Richie, Brandon K Harvey, Robert F Dannals, Martin G Pomper, Antonello Bonci, Michael Michaelides
The chemogenetic technology DREADD (designer receptors exclusively activated by designer drugs) is widely used for remote manipulation of neuronal activity in freely moving animals. DREADD technology posits the use of "designer receptors," which are exclusively activated by the "designer drug" clozapine N-oxide (CNO). Nevertheless, the in vivo mechanism of action of CNO at DREADDs has never been confirmed. CNO does not enter the brain after systemic drug injections and shows low affinity for DREADDs. Clozapine, to which CNO rapidly converts in vivo, shows high DREADD affinity and potency...
August 4, 2017: Science
https://www.readbyqxmd.com/read/28773982/reduced-subthreshold-characteristics-and-flicker-noise-of-an-algaas-ingaas-phemt-using-liquid-phase-deposited-tio%C3%A2-as-a-gate-dielectric
#9
Kai-Yuen Lam, Jung-Sheng Huang, Yong-Jie Zou, Kuan-Wei Lee, Yeong-Her Wang
This study presents the fabrication and improved properties of an AlGaAs/InGaAs metal-oxide-semiconductor pseudomorphic high-electron-mobility transistor (MOS-PHEMT) using liquid phase deposited titanium dioxide (LPD-TiO₂) as a gate dielectric. Sulfur pretreatment and postoxidation rapid thermal annealing (RTA) were consecutively employed before and after the gate dielectric was deposited to fill dangling bonds and therefore release interface trapped charges. Compared with a benchmark PHEMT, the AlGaAs/InGaAs MOS-PHEMT using LPD-TiO₂ exhibited larger gate bias operation, higher breakdown voltage, suppressed subthreshold characteristics, and reduced flicker noise...
October 25, 2016: Materials
https://www.readbyqxmd.com/read/28773058/high-mobility-thin-film-transistors-based-on-amorphous-indium-zinc-tin-oxide
#10
Imas Noviyana, Annisa Dwi Lestari, Maryane Putri, Mi-Sook Won, Jong-Seong Bae, Young-Woo Heo, Hee Young Lee
Top-contact bottom-gate thin film transistors (TFTs) with zinc-rich indium zinc tin oxide (IZTO) active layer were prepared at room temperature by radio frequency magnetron sputtering. Sintered ceramic target was prepared and used for deposition from oxide powder mixture having the molar ratio of In2O3:ZnO:SnO2 = 2:5:1. Annealing treatment was carried out for as-deposited films at various temperatures to investigate its effect on TFT performances. It was found that annealing treatment at 350 °C for 30 min in air atmosphere yielded the best result, with the high field effect mobility value of 34 cm2/Vs and the minimum subthreshold swing value of 0...
June 26, 2017: Materials
https://www.readbyqxmd.com/read/28772789/transparent-thin-film-transistors-based-on-sputtered-electric-double-layer
#11
Wensi Cai, Xiaochen Ma, Jiawei Zhang, Aimin Song
Electric-double-layer (EDL) thin-film transistors (TFTs) have attracted much attention due to their low operation voltages. Recently, EDL TFTs gated with radio frequency (RF) magnetron sputtered SiO₂ have been developed which is compatible to large-area electronics fabrication. In this work, fully transparent Indium-Gallium-Zinc-Oxide-based EDL TFTs on glass substrates have been fabricated at room temperature for the first time. A maximum transmittance of about 80% has been achieved in the visible light range...
April 20, 2017: Materials
https://www.readbyqxmd.com/read/28772487/high-responsivity-mgzno-ultraviolet-thin-film-phototransistor-developed-using-radio-frequency-sputtering
#12
Jyun-Yi Li, Sheng-Po Chang, Ming-Hung Hsu, Shoou-Jinn Chang
We investigated the electrical and optoelectronic properties of a magnesium zinc oxide thin-film phototransistor. We fabricate an ultraviolet phototransistor by using a wide-bandgap MgZnO thin film as the active layer material of the thin film transistor (TFT). The fabricated device demonstrated a threshold voltage of 3.1 V, on-off current ratio of 10⁵, subthreshold swing of 0.8 V/decade, and mobility of 5 cm²/V·s in a dark environment. As a UV photodetector, the responsivity of the device was 3.12 A/W, and the rejection ratio was 6...
February 4, 2017: Materials
https://www.readbyqxmd.com/read/28768741/theta-frequency-selectivity-in-the-somatic-spike-triggered-average-of-rat-hippocampal-pyramidal-neurons-is-dependent-on-hcn-channels
#13
Anindita Das, Rishikesh Narayanan
The ability to distill specific frequencies from complex spatiotemporal patterns of afferent inputs is a pivotal functional requirement for neurons residing in networks receiving frequency-multiplexed inputs. Although the expression of theta-frequency subthreshold resonance is established in hippocampal pyramidal neurons, it is not known if their spike initiation dynamics manifest spectral selectivity or if their intrinsic properties are tuned to process gamma-frequency inputs. Here, we measured the spike-triggered average (STA) of rat hippocampal pyramidal neurons through electrophysiological recordings and quantified spectral selectivity in their spike initiation dynamics and their coincidence detection window (CDW)...
August 2, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28768599/pre-onset-risk-characteristics-for-mania-among-young-people-at-clinical-high-risk-for-psychosis
#14
Aswin Ratheesh, Susan M Cotton, Christopher G Davey, Ashleigh Lin, Stephen Wood, Hok Pan Yuen, Andreas Bechdolf, Patrick D McGorry, Alison Yung, Michael Berk, Barnaby Nelson
INTRODUCTION: Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. METHODS: Among a cohort of 416 young people with an at-risk mental state for psychosis defined using the Ultra-High-Risk (UHR) criteria, 74...
May 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28767216/room-temperature-fabrication-of-high-performance-amorphous-in-ga-zn-o-al2o3-thin-film-transistors-on-ultra-smooth-and-clear-nanopaper
#15
Honglong Ning, Yong Zeng, Yudi Kuang, Zeke Zheng, Panpan Zhou, Rihui Yao, Hongke Zhang, Wenzhong Bao, Gang Chen, Zhiqiang Fang, Junbiao Peng
Integrating biodegradable cellulose nanopaper into oxide thin-film transistors (TFTs) for next generation flexible and green flat panel displays has attracted great interests because it offers a viable solution to address the rapid increase of electronic waste that poses a growing ecological problem. However, a compromise between device performance and thermal annealing remains an obstacle for achieving high-performance nanopaper TFTs. In this study, a high-performance bottom-gate IGZO/Al2O3 TFT with a dual-layer channel structure was initially fabricated on a highly transparent, clear, and ultra-smooth nanopaper substrate via conventional physical vapor deposition approaches, without a further thermal annealing processing...
August 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28764679/economic-evaluation-of-stepped-care-versus-usual-care-for-depression-and-anxiety-in-older-adults-with-vision-impairment-randomized-controlled-trial
#16
Hilde P A van der Aa, Ger H M B van Rens, Judith E Bosmans, Hannie C Comijs, Ruth M A van Nispen
BACKGROUND: A stepped-care program was found effective in preventing depressive and anxiety disorders in older adults with vision impairment. However, before a decision can be made about implementation, the cost-effectiveness of this program should be investigated. Therefore, we aimed to compare the cost-effectiveness of stepped-care versus usual care within low vision rehabilitation. METHODS: An economic evaluation from a societal perspective was performed alongside a multicenter randomized controlled trial...
August 1, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28764008/2-methylbutyl-acetate-in-wines-enantiomeric-distribution-and-sensory-impact-on-red-wine-fruity-aroma
#17
Margaux Cameleyre, Georgia Lytra, Sophie Tempere, Jean-Christophe Barbe
Enantiomers of 2-methylbutyl acetate were assayed in red and white commercial wines from various vintages and origins, using chiral gas chromatography (γ-cyclodextrin), revealing the exclusive presence of the S-enantiomeric form. Results also confirmed that (S)-2-methylbutyl acetate levels were generally higher in red than white wines of the same age, and that acetate levels increased gradually during ageing. Olfactory threshold of (S)-2-methylbutyl acetate was evaluated at 313µg/L in dilute alcohol solution (12% v/v) and 1083µg/L in a fruity aromatic reconstitution, reflecting its presence in wines at subthreshold concentrations...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763451/effectiveness-of-a-stepped-care-intervention-to-prevent-major-depression-in-patients-with-type-2-diabetes-mellitus-and-or-coronary-heart-disease-and-subthreshold-depression-a-pragmatic-cluster-randomized-controlled-trial
#18
Alide D Pols, Susan E van Dijk, Judith E Bosmans, Trynke Hoekstra, Harm W J van Marwijk, Maurits W van Tulder, Marcel C Adriaanse
PURPOSE: Given the public health significance of poorly treatable co-morbid major depressive disorders (MDD) among patients with type 2 diabetes mellitus (DM2) and coronary heart disease (CHD), we need to investigate whether strategies to prevent the development of major depression could reduce its burden of disease. We therefore evaluated the effectiveness of a stepped-care program for subthreshold depression in comparison with usual care in patients with DM2 and/or CHD. METHODS: A cluster randomized controlled trial, with 27 primary care centers serving as clusters...
2017: PloS One
https://www.readbyqxmd.com/read/28761081/a-neurogenetic-model-for-the-study-of-schizophrenia-spectrum-disorders-the-international-22q11-2-deletion-syndrome-brain-behavior-consortium
#19
R E Gur, A S Bassett, D M McDonald-McGinn, C E Bearden, E Chow, B S Emanuel, M Owen, A Swillen, M Van den Bree, J Vermeesch, J A S Vorstman, S Warren, T Lehner, B Morrow
Rare copy number variants contribute significantly to the risk for schizophrenia, with the 22q11.2 locus consistently implicated. Individuals with the 22q11.2 deletion syndrome (22q11DS) have an estimated 25-fold increased risk for schizophrenia spectrum disorders, compared to individuals in the general population. The International 22q11DS Brain Behavior Consortium is examining this highly informative neurogenetic syndrome phenotypically and genomically. Here we detail the procedures of the effort to characterize the neuropsychiatric and neurobehavioral phenotypes associated with 22q11DS, focusing on schizophrenia and subthreshold expression of psychosis...
August 1, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28756011/impact-of-posttraumatic-stress-symptom-dimensions-on-amygdala-reactivity-to-emotional-faces
#20
Lynne Lieberman, Stephanie M Gorka, Julia A DiGangi, Alyssa Frederick, K Luan Phan
Posttraumatic stress disorder (PTSD) is highly prevalent and associated with impairment, even at the subthreshold level. It is therefore important to identify biological processes that contribute to the pathophysiology of posttraumatic stress symptoms (PTSS). Although neuroimaging research has highlighted the importance of heightened amygdala reactivity to aversive stimuli in PTSS, not all studies have yielded evidence of this relationship. Given that PTSS is comprised of four, factor analytically distinct dimensions of symptoms - re-experiencing, avoidance, hyperarousal, and negative cognitions and mood - it is possible that heightened amygdala reactivity to aversive stimuli is specific to certain PTSS clusters...
July 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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