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https://www.readbyqxmd.com/read/28228266/rapid-state-dependent-alteration-in-kv3-channel-availability-drives-flexible-synaptic-signaling-dependent-on-somatic-subthreshold-depolarization
#1
Matthew J M Rowan, Jason M Christie
In many neurons, subthreshold depolarization in the soma can transiently increase action-potential (AP)-evoked neurotransmission via analog-to-digital facilitation. The mechanisms underlying this form of short-term synaptic plasticity are unclear, in part, due to the relative inaccessibility of the axon to direct physiological interrogation. Using voltage imaging and patch-clamp recording from presynaptic boutons of cerebellar stellate interneurons, we observed that depolarizing somatic potentials readily spread into the axon, resulting in AP broadening, increased spike-evoked Ca(2+) entry, and enhanced neurotransmission strength...
February 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28227582/reconfigurable-analog-classifier-for-knee-joint-rehabilitation
#2
Sahil Shah, Hakan Toreyin, Omer T Inan, Jennifer Hasler, Sahil Shah, Hakan Toreyin, Omer T Inan, Jennifer Hasler, Sahil Shah, Jennifer Hasler, Omer T Inan, Hakan Toreyin
We present a System-On-Chip Field Programmable Analog Array (FPAA) for analyzing and processing the signals off an accelerometer for a wearable joint health assessment device. FPAAs have been shown to compute with an efficiency of 1000 times, as well as area efficiencies of 100 times, more than digital solutions. This work presents a low power signal processing system which allows us to extract features from the output of the accelerometer. These features are used by the classifier, implemented using a vector matrix multiplication and a two output 1-winner-take-all, to detect flexion and extension cycles in the subject...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226481/subthreshold-linear-modeling-of-dendritic-trees-a-computational-approach
#3
Alireza Khodaei, Massimiliano Pierobon, Alireza Khodaei, Massimiliano Pierobon, Alireza Khodaei, Massimiliano Pierobon
The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous system, in recent work the authors of this paper proposed the so-called subthreshold electrical stimulation as a viable technique to propagate artificial information through neurons...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223149/long-term-behavioral-change-as-a-result-of-acute-ethanol-exposure-in-zebrafish-evidence-for-a-role-for-sonic-hedgehog-but-not-retinoic-acid-signaling
#4
Derek Burton, Chengjin Zhang, Oswald Boa-Amponsem, Shanta Mackinnon, Gregory J Cole
BACKGROUND: Developmental exposure to ethanol is recognized to produce long-term neurobehavioral impairment in multiple animal models. However, the molecular mechanisms underlying these deficits remain poorly understood. The present study was undertaken to ascertain whether two well-characterized targets of prenatal alcohol exposure, sonic hedgehog (Shh) and retinoic acid (RA), that induce the hallmark morphological phenotypes of fetal alcohol spectrum disorders (FASD), are involved in the generation of behavioral alterations as a result of alcohol exposure...
February 18, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28217713/catching-the-voltage-gradient-asymmetric-boost-of-cortical-spread-generates-motion-signals-across-visual-cortex-a-brief-review-with-special-thanks-to-amiram-grinvald
#5
REVIEW
Dirk Jancke
Wide-field voltage imaging is unique in its capability to capture snapshots of activity-across the full gradient of average changes in membrane potentials from subthreshold to suprathreshold levels-of hundreds of thousands of superficial cortical neurons that are simultaneously active. Here, I highlight two examples where voltage-sensitive dye imaging (VSDI) was exploited to track gradual space-time changes of activity within milliseconds across several millimeters of cortex at submillimeter resolution: the line-motion condition, measured in Amiram Grinvald's Laboratory more than 10 years ago and-coming full circle running VSDI in my laboratory-another motion-inducing condition, in which two neighboring stimuli counterchange luminance simultaneously...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28211549/review-of-health-and-risk-behaviours-mental-health-problems-and-suicidal-behaviours-in-young-europeans-on-the-basis-of-the-results-from-the-eu-funded-saving-and-empowering-young-lives-in-europe-seyle-study
#6
REVIEW
Danuta Wasserman
An estimated 800 000 suicide deaths occur worldwide. The global suicide rate is 11.4 per 100 000 population; 15.0/100 000 for males and 8.0/100 000 for females. Globally, suicide is the second leading cause of death in 15-29 year olds. In a collaborative effort to reduce the high rates of suicide and mental health problems among youth across Europe, the European Union 7th Framework funded the Saving and Empowering Young Lives in Europe (SEYLE) project. SEYLE is a randomized controlled trial (RCT) aimed to promote mental health and healthy lifestyles, while preventing psychopathology and suicidal behaviours among adolescents...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28210778/threshold-dose-for-behavioral-discrimination-of-cigarette-nicotine-content-in-menthol-vs-non-menthol-smokers
#7
Kenneth A Perkins, Nicole Kunkle, Joshua L Karelitz
RATIONALE: The lowest threshold content (or "dose") of nicotine discriminated in cigarettes may differ due to menthol preference. OBJECTIVES: Menthol and non-menthol Spectrum research cigarettes differing in nicotine content were used to determine discrimination thresholds. METHODS: Dependent smokers preferring menthol (n = 40) or non-menthol (n = 21) brands were tested on ability to discriminate cigarettes (matched for their menthol preference) with nicotine contents of 16-17, 11-12, 5, 2, and 1 mg/g, one per session, from an "ultra-low" cigarette with 0...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28210218/phasic-firing-and-coincidence-detection-by-subthreshold-negative-feedback-divisive-or-subtractive-or-better-both
#8
Gemma Huguet, Xiangying Meng, John Rinzel
Phasic neurons typically fire only for a fast-rising input, say at the onset of a step current, but not for steady or slow inputs, a property associated with type III excitability. Phasic neurons can show extraordinary temporal precision for phase locking and coincidence detection. Exemplars are found in the auditory brain stem where precise timing is used in sound localization. Phasicness at the cellular level arises from a dynamic, voltage-gated, negative feedback that can be recruited subthreshold, preventing the neuron from reaching spike threshold if the voltage does not rise fast enough...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28204757/subthreshold-psychosis-in-22q11-2-deletion-syndrome-multisite-naturalistic-study
#9
Omri Weisman, Yael Guri, Raquel E Gur, Donna M McDonald-McGinn, Monica E Calkins, Sunny X Tang, Beverly Emanuel, Elaine H Zackai, Stephan Eliez, Maude Schneider, Marie Schaer, Wendy R Kates, Kevin M Antshel, Wanda Fremont, Vandana Shashi, Stephen R Hooper, Marco Armando, Stefano Vicari, Maria Pontillo, Leila Kushan, Maria Jalbrzikowski, Carrie E Bearden, Joseph F Cubells, Opal Y Ousley, Elaine F Walker, Tony J Simon, Joel Stoddard, Tara A Niendam, Marianne B M van den Bree, Doron Gothelf
No abstract text is available yet for this article.
February 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28202569/local-vs-volume-conductance-activity-of-field-potentials-in-the-human-subthalamic-nucleus
#10
Odeya Marmor, Dan Valsky, Mati Joshua, Atira S Bick, David Arkadir, Idit Tamir, Hagai Bergmann, Zvi Israel, Renana Eitan
BACKGROUND: Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume conductance of the organized neuronal activity generated in the cortex. OBJECTIVE: This study aimed at understanding of the physiological origin of subthalamic field potentials and determining the most accurate method for recording them...
February 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28202254/robust-interactions-between-the-effects-of-auditory-and-cutaneous-electrical-stimulations-on-cell-activities-in-the-thalamic-reticular-nucleus
#11
Akihisa Kimura
The thalamic reticular nucleus (TRN), a cluster of GABAergic cells, is thought to regulate bottom-up and top-down streams of sensory processing in the loop circuitry between the thalamus and cortex. Provided that sensory inputs of different modalities interact in the TRN, the TRN could contribute to fast and flexible cross-modal modulation of attention and perception that incessantly takes place in our every day life. Indeed, diverse subthreshold interactions of auditory and visual inputs have been revealed in TRN cells (Kimura, 2014)...
February 12, 2017: Brain Research
https://www.readbyqxmd.com/read/28199910/subthreshold-body-dysmorphic-disorder-in-adolescents-prevalence-and-impact
#12
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The aim of the current study was to establish the prevalence of subthreshold body dysmorphic disorder (subthreshold-BDD) in a community sample of adolescents, and to compare disorder correlates in individuals with subthreshold-BDD to those with probable full-syndrome BDD (probable-BDD) and those without BDD (non-BDD). Self-report questionnaires assessing DSM-IV BDD criteria, past mental health service use, and symptoms of body dysmorphic disorder, anxiety, depression, obsessive-compulsive disorder and eating disorders, were completed by 3149 Australian high school students (mean age =14...
January 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28193892/kv1-1-channelopathy-abolishes-presynaptic-spike-width-modulation-by-subthreshold-somatic-depolarization
#13
Umesh Vivekananda, Pavel Novak, Oscar D Bello, Yuri E Korchev, Shyam S Krishnakumar, Kirill E Volynski, Dimitri M Kullmann
Although action potentials propagate along axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic boutons. An important mechanism underlying analog-digital modulation is depolarization-mediated inactivation of presynaptic Kv1-family potassium channels, leading to action potential broadening and increased calcium influx. Previous studies have relied heavily on recordings from blebs formed after axon transection, which may exaggerate the passive propagation of somatic depolarization...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193067/biorecognition-in-organic-field-effect-transistors-biosensors-the-role-of-the-density-of-states-of-the-organic-semiconductor
#14
Marcello Berto, Stefano Casalini, Michele Di Lauro, Simone L Marasso, Matteo Cocuzza, Denis Perrone, Marcello Pinti, Andrea Cossarizza, Candido F Pirri, Daniel T Simon, Magnus Berggren, Francesco Zerbetto, Carlo A Bortolotti, Fabio Biscarini
Biorecognition is a central event in biological processes in the living systems that is also widely exploited in technological and health applications. We demonstrate that the Electrolyte Gated Organic Field Effect Transistor (EGOFET) is an ultrasensitive and specific device that allows us to quantitatively assess the thermodynamics of biomolecular recognition between a human antibody and its antigen, namely, the inflammatory cytokine TNFα at the solid/liquid interface. The EGOFET biosensor exhibits a superexponential response at TNFα concentration below 1 nM with a minimum detection level of 100 pM...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28192671/electron-deficient-dihydroindaceno-dithiophene-regioisomers-for-n-type-organic-field-effect-transistors
#15
Jean-David Peltier, Benoît Heinrich, Bertrand Donnio, Joëlle Rault-Berthelot, Emmanuel Jacques, Cyril Poriel
In this work, we wish to report the first member of a new family of organic semiconductors constructed on a meta dihydroindacenodithiophene core, that is, 2,2'-(2,8-dihexyl-4,6-dihydro-s-indaceno[1,2-b:7,6-b']dithiophene-4,6-diylidene)dimalononitrile (called meta-IDT(═C(CN)2)2). The properties of this molecule were studied in detail through a structure-properties relationship study with its regioisomer, that is, 2,2'-(2,7-dihexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-4,9-diylidene)dimalononitrile (para-IDT(═C(CN)2)2) (see isomer structures in blue in Chart 2)...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28191930/bandgap-extraction-and-device-analysis-of-ionic-liquid-gated-wse2-schottky-barrier-transistors
#16
Abhijith Prakash, Joerg Appenzeller
Through the careful study of ionic liquid gated WSe2 Schottky barrier field-effect transistors as a function of flake thickness-referred to in the following as body thickness, tbody-critical insights into the electrical properties of WSe2 are gained. One finding is that the inverse subthreshold slope shows a clear dependence on body thickness, i.e., an approximate square root dependent increase with tbody, that provides evidence that injection into the WSe2 channel is mediated by thermally assisted tunneling through the gate-controlled Schottky barriers at the source and drain...
February 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28186654/weight-gain-trajectories-in-hospital-based-treatment-of-anorexia-nervosa
#17
Saniha H Makhzoumi, Janelle W Coughlin, Colleen C Schreyer, Graham W Redgrave, Steven C Pitts, Angela S Guarda
Weight gain is a primary treatment goal for anorexia nervosa (AN); however little is known about heterogeneity in weight gain pattern during treatment. Preliminary evidence suggests weight gain trajectory is associated with treatment outcome. This study grouped patients using mixture modeling into weight gain trajectories, and compared predictors and treatment outcomes between trajectory groups. Women diagnosed with AN or subthreshold AN (N = 211) completed self-report measures at admission and six-months after discharge from an integrated inpatient (IP)-partial hospitalization (PH) behavioral specialty eating disorders program...
February 10, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28185205/a-review-of-subthreshold-micropulse-laser-and-recent-advances-in-retinal-laser-technology
#18
REVIEW
Daniel Su, Jean-Pierre Hubschman
The role of retinal photocoagulation as a first line therapy for various retinal pathologies has decreased with the introduction of anti-vascular endothelial growth factor therapy. However, retinal laser therapy remains an important treatment modality, especially with the emergence of micropulse subthreshold treatment and the integration of newer technology such as augmented reality and semi-automated delivery. This review summarizes current evidence for micropulse laser as a treatment modality and discusses the role of new technology such as augmented reality in the future of laser therapy...
February 9, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28184189/gender-differences-in-neural-responses-to-perceptually-invisible-fearful-face-an-erp-study
#19
Seung A Lee, Chai-Youn Kim, Miseon Shim, Seung-Hwan Lee
Women tend to respond to emotional stimuli differently from men. This study aimed at investigating whether neural responses to perceptually "invisible" emotional stimuli differ between men and women by exploiting event-related potential (ERP). Forty healthy participants (21 women) were recruited for the main experiment. A control experiment was conducted by excluding nine (7 women) participants from the main experiment and replacing them with additional ten (6 women) participants (total 41 participants) where Beck's Anxiety Inventory (BAI) and Beck's Depression Inventory (BDI) scores were controlled...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28169460/alterations-of-the-hematologic-cells-in-synthetic-cannabinoid-users
#20
Derya Guzel, Ahmet Bulent Yazici, Esra Yazici, Atila Erol
BACKGROUND: Functions, morphology, distributions, and index of the circulating cells are the most useful parameters that indicate various inflammatory and toxic conditions. The aim of this study was to investigate the clinical significance of these parameters in patients diagnosed with (synthetic) cannabis use disorder. METHODS: This study included a total of 40 patients in the study group (SG) with synthetic cannabis use; and 40 healthy individuals as the control group (CG)...
February 7, 2017: Journal of Clinical Laboratory Analysis
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