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Near-infrared fluorescence imaging

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https://www.readbyqxmd.com/read/28742709/prospective-evaluation-of-precision-multimodal-gallbladder-surgery-navigation-virtual-reality-near-infrared-fluorescence-and-x-ray-based-intraoperative-cholangiography
#1
Michele Diana, Luc Soler, Vincent Agnus, Antonio D'Urso, Michel Vix, Bernard Dallemagne, Vanina Faucher, Catherine Roy, Didier Mutter, Jacques Marescaux, Patrick Pessaux
OBJECTIVE: We aimed to prospectively evaluate NIR-C, VR-AR, and x-ray intraoperative cholangiography (IOC) during robotic cholecystectomy. BACKGROUND: Near-infrared cholangiography (NIR-C) provides real-time, radiation-free biliary anatomy enhancement. Three-dimensional virtual reality (VR) biliary anatomy models can be obtained via software manipulation of magnetic resonance cholangiopancreatography, enabling preoperative VR exploration, and intraoperative augmented reality (AR) navigation...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28741598/plasmonic-enhancement-of-cyanine-dyes-for-near-infrared-light-triggered-photodynamic-photothermal-therapy-and-fluorescent-imaging
#2
Mindan Lu, Ning Kang, Chuan Chen, Liuqing Yang, Yang Li, Minghui Hong, Xiangang Luo, Lei Ren, Xiumin Wang
Near infrared (NIR) triggered cyanine dyes have attracted considerable attentions in multi-modal tumor theranostics. However, near infrared (NIR) cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacies for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent of AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0...
July 25, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28741043/comparison-of-near-infrared-imaging-camera-systems-for-intracranial-tumor-detection
#3
Steve S Cho, Ryan Zeh, John T Pierce, Ryan Salinas, Sunil Singhal, John Y K Lee
PURPOSE: Distinguishing neoplasm from normal brain parenchyma intraoperatively is critical for the neurosurgeon. 5-Aminolevulinic acid (5-ALA) has been shown to improve gross total resection and progression-free survival but has limited availability in the USA. Near-infrared (NIR) fluorescence has advantages over visible light fluorescence with greater tissue penetration and reduced background fluorescence. In order to prepare for the increasing number of NIR fluorophores that may be used in molecular imaging trials, we chose to compare a state-of-the-art, neurosurgical microscope (System 1) to one of the commercially available NIR visualization platforms (System 2)...
July 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28738592/a-unique-red-emitting-two-photon-fluorescent-probe-with-tumor-specificity-for-imaging-in-living-cells-and-tissues
#4
Xiuqi Kong, Baoli Dong, Nan Zhang, Chao Wang, Xuezhen Song, Weiying Lin
Tumor-specific imaging can provide an attractive approach for the early detection and prognosis of cancer, as well as the precise image-guided tumor-removal surgery. Herein, we describe a unique red-emitting two-photon fluorescent probe (N-BN) for tumor-specific imaging. N-BN utilized Nile Red as the red-emitting two-photon fluorophore and employed biotin as the tumor-specific ligand. In the presence of a variety of biomolecules or in different pH buffers, the fluorescence intensity of N-BN at 655nm showed no noticeable change...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738091/the-second-window-icg-technique-demonstrates-a-broad-plateau-period-for-near-infrared-fluorescence-tumor-contrast-in-glioblastoma
#5
Ryan Zeh, Saad Sheikh, Leilei Xia, John Pierce, Andrew Newton, Jarrod Predina, Steve Cho, MacLean Nasrallah, Sunil Singhal, Jay Dorsey, John Y K Lee
INTRODUCTION: Fluorescence-guided surgery has emerged as a powerful tool to detect, localize and resect tumors in the operative setting. Our laboratory has pioneered a novel way to administer an FDA-approved near-infrared (NIR) contrast agent to help surgeons with this task. This technique, coined Second Window ICG, exploits the natural permeability of tumor vasculature and its poor clearance to deliver high doses of indocyanine green (ICG) to tumors. This technique differs substantially from established ICG video angiography techniques that visualize ICG within minutes of injection...
2017: PloS One
https://www.readbyqxmd.com/read/28737890/a-difluoroboron-%C3%AE-diketonate-probe-shows-turn-on-near-infrared-fluorescence-specific-for-tau-fibrils
#6
Kwang-Su Park, Mi Kyoung Kim, Yujin Seo, Taewoong Ha, Kyeongha Yoo, Seung Jae Hyeon, Yu Jin Hwang, Junghee Lee, Hoon Ryu, Hyunah Choo, Youhoon Chong
Tau aggregation in neuronal cells has recently received significant attention as a robust predictor of the progression of Alzheimer's disease (AD) because of its proven correlation with the degree of cognitive impairment in AD patients. Accordingly, non-invasive imaging of tau aggregates has been highlighted as a promising diagnostic tool for AD. We have previously identified a tau-specific "turn-on" near-infrared fluorescent (NIRF) probe (1) and, in this study, structural modification was performed to optimize its physicochemical as well as fluorescence properties...
July 24, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28732936/oxygen-and-indocyanine-green-loaded-microparticles-for-dual-mode-imaging-and-sonodynamic-treatment-of-cancer-cells
#7
Rong Ma, Qiang Wu, Ting Si, Shufang Chang, Ronald X Xu
Oxygen and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT). The produced OI-MPs agent showed stable optical properties, superior imaging depth in near infrared (NIR) fluorescence imaging, and enhanced acoustic contrast after ultrasound mediation. We hypothesized that encapsulating ICG and oxygen in microparticles would enhance reactive oxygen species (ROS) production in SDT. This hypothesis was validated in a cell-free environment...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732245/interleukin-4-receptor-targeted-delivery-of-bcl-xl-sirna-sensitizes-tumors-to-chemotherapy-and-inhibits-tumor-growth
#8
Padmanaban Guruprasath, Jihoon Kim, Gowri Rangaswamy Gunassekaran, Lianhua Chi, Soyoun Kim, Rang-Woon Park, Sang-Hyun Kim, Moon-Chang Baek, Sang Mun Bae, Sang-Yeob Kim, Dong-Kyu Kim, In-Kyu Park, Won-Jong Kim, Byungheon Lee
IL-4 receptor (IL-4R) is commonly up-regulated on tumor cells, and interactions between the receptor and Interleukin-4 (IL-4) can induce the expression of anti-apoptotic proteins, including Bcl-xL. This contributes to tumor cell survival and their resistance to chemotherapy. In this study, we exploited IL-4R-targeted delivery of Bcl-xL siRNA to IL-4R-expressing tumor cells in order to sensitize them to chemotherapy. To target IL-4R, an IL-4R-binding peptide, IL4RPep-1, was attached to branched polyethyleneimine-superparamagnetic iron oxide nanoparticles (BPEI-SPION)...
July 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28729400/vessel-targeted-chemophototherapy-with-cationic-porphyrin-phospholipid-liposomes
#9
Dandan Luo, Jumin Geng, Nasi Li, Kevin A Carter, Shuai Shao, G Ekin Atilla-Gokcumen, Jonathan F Lovell
Cationic liposomes have been used for targeted drug delivery to tumor blood vessels, via mechanisms that are not fully elucidated. Doxorubicin (Dox)-loaded liposomes were prepared that incorporate a cationic lipid; 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), along with a small amount of porphyrin-phospholipid (PoP). Near infrared (NIR) light induced release of entrapped Dox via PoP-mediated DOTAP photo-oxidation. The formulation was optimized to enable extremely rapid NIR light-triggered Dox release (i...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28727149/aortic-microcalcification-associates-with-elastin-fragmentation-in-marfan-syndrome
#10
Shaynah A Wanga, Stijntje Hibender, Yanto Ridwan, Cindy van Roomen, Mariska Vos, Ingeborg van der Made, Nicole van Vliet, Romy Franken, Luigi Amjg van Riel, Maarten Groenink, Aeilko H Zwinderman, Barbara Jm Mulder, Carlie Jm de Vries, Jeroen Essers, Vivian de Waard
Marfan syndrome (MFS) is a connective tissue disorder, in which aortic rupture is the major cause of death. MFS patients with an aortic diameter below the advised limit for prophylactic surgery (<5cm) may unexpectedly experience an aortic dissection or rupture, despite yearly monitoring. Hence, there is a clear need for improved prognostic markers to predict such aortic events. We hypothesize that elastin fragments play a causal role in aortic calcification in MFS and that microcalcification serves as a marker for aortic disease severity...
July 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28726863/a-near-infrared-fluorescence-off-on-probe-for-sensitive-imaging-of-hydrogen-polysulfides-in-living-cells-and-mice-in-vivo
#11
Yu Fang, Wei Chen, Wen Shi, Hongyu Li, Ming Xian, Huimin Ma
A new hemicyanine-based near-infrared fluorescence off-on probe with phenyl 2-(benzoylthio)benzoate as the recognition moiety to trap hydrogen polysulfides (H2Sn, n > 1) is developed, and is used for the sensitive imaging of H2Sn in cells and mice in vivo.
July 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28726724/theoretical-studies-on-two-photon-fluorescent-hg-2-probes-based-on-the-coumarin-rhodamine-system
#12
Yujin Zhang, Jiancai Leng
The development of fluorescent sensors for Hg(2+) has attracted much attention due to the well-known adverse effects of mercury on biological health. In the present work, the optical properties of two newly-synthesized Hg(2+) chemosensors based on the coumarin-rhodamine system (named Pro1 and Pro2) were systematically investigated using time-dependent density functional theory. It is shown that Pro1 and Pro2 are effective ratiometric fluorescent Hg(2+) probes, which recognize Hg(2+) by Förster resonance energy transfer and through bond energy transfer mechanisms, respectively...
July 20, 2017: Sensors
https://www.readbyqxmd.com/read/28717564/electrically-tunable-fluidic-lens-imaging-system-for-laparoscopic-fluorescence-guided-surgery
#13
Davide Volpi, Iain D C Tullis, Paul R Barber, Edyta M Augustyniak, Sean C Smart, Katherine A Vallis, Borivoj Vojnovic
The addition of fluorescence guidance in laparoscopic procedures has gained significant interest in recent years, particularly through the use of near infrared (NIR) markers. In this work we present a novel laparoscope camera coupler based on an electrically tunable fluidic lens that permits programmable focus control and has desirable achromatic performance from the visible to the NIR. Its use extends the lower working distance limit and improves detection sensitivity, important for work with molecularly targeted fluorescence markers...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28713673/intraoperative-near-infrared-imaging-of-mesothelioma
#14
REVIEW
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
Though difficult to achieve, complete resection of malignant pleural mesothelioma is paramount to improving patient survival. Surgeons have traditionally been limited to using visual inspection and manual palpation to locate and remove cancerous tissue. However, intraoperative molecular imaging (IMI) is a promising new technology in surgery. Molecular imaging utilizes a fluorescent tracer that selectively accumulates in cancer cells. An imaging device is then used to detect and augment the fluorescent signal emitted from the fluorescent cancer cells...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28706202/near-infrared-autofluorescence-induced-by-intraplaque-hemorrhage-and-heme-degradation-as-marker-for-high-risk-atherosclerotic-plaques
#15
Nay Min Htun, Yung Chih Chen, Bock Lim, Tara Schiller, Ghassan J Maghzal, Alex L Huang, Kirstin D Elgass, Jennifer Rivera, Hans G Schneider, Bayden R Wood, Roland Stocker, Karlheinz Peter
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28700898/sub-100nm-long-tumor-retention-sn-38-loaded-photonic-micelles-for-tri-modal-cancer-therapy
#16
Xixiao Yang, Xiangdong Xue, Yan Luo, Tzu-Yin Lin, Hongyong Zhang, Diana Lac, Kai Xiao, Yixuan He, Bei Jia, Kit S Lam, Yuanpei Li
The tumor penetration and accumulation of nanoparticle-based drug delivery systems are highly dependent on the particle size. Nanomedicines in the sub-100nm range have been suggested by previous studies to have superior antitumor efficacy on various solid tumors. SN-38 is a very important and highly potent drug for several cancers including colon cancer. However, due to the ultra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100nm, SN-38-encapsulated nanoparticles without modification of the chemical structure...
July 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28700137/dual-led-based-multichannel-microscopy-for-whole-slide-multiplane-multispectral-and-phase-imaging
#17
Jun Liao, Zhe Wang, Zibang Zhang, Zichao Bian, Kaikai Guo, Aparna Nambiar, Yutong Jiang, Shaowei Jiang, Jingang Zhong, Michael Choma, Guoan Zheng
We report the development of a multichannel microscopy for whole-slide multiplane, multispectral, and phase imaging. We use trinocular heads to split the beam path into 6 independent channels and employ a camera array for parallel data acquisition, achieving a maximum data throughput of ~1 gigapixel per second. To perform single-frame rapid autofocusing, we place two near-infrared LEDs at the back focal plane of the condenser lens to illuminate the sample from two different incident angles. A hot mirror is used to direct the near-infrared light to an autofocusing camera...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28699321/indolizine-squaraines-nir-fluorescent-materials-with-molecular-engineered-stokes-shifts
#18
Louis Edward McNamara, Tana A Rill, Aron J Huckaba, Vigneshraja Ganeshraj Ganeshraj, Jacqueline Gayton, Rachael A Nelson, Emily Anne Sharpe, Amala Dass, Nathan I Hammer, Jared Heath Delcamp
The development of deep red and near infrared emissive materials with high quantum yields is an important challenge. Several classes of squaraine dyes have demonstrated high quantum yields, but require significantly red-shifted absorptions to access the NIR window. Additionally, squaraine dyes have typically shown narrow Stokes shifts, which limits their use in living biological imaging applications due to dye emission interference with the light source. Through the incorporation of indolizine heterocycles we have synthesized novel indolizine squaraine dyes with increased Stokes shifts (>50 nm increase) and absorptions substantially further into the NIR region than an indoline squaraine benchmark (726 nm versus 659 nm absorption maxima)...
July 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28696099/activatable-qd-based-near-infrared-fluorescence-probe-for-sensitive-detection-and-imaging-of-dna
#19
Yizhong Shen, Nan Zhang, Yidan Sun, Wei-Wei Zhao, Deju Ye, Jing-Juan Xu, Hong-Yuan Chen
Accurate detection of DNA is essential for the precise diagnosis of diseases. Here we report an activatable near-infrared (NIR) fluorescence nanoprobe (QD-Al-GFLX) composed of NIR quantum dots (QDs) and Al(III)-gatifloxacin (Al-GFLX) complexes for the sensitive detection of double-stranded DNA (dsDNA) both in aqueous solution and in living cells. We demonstrated that the initial strong NIR fluorescence of QDs in QD-Al-GFLX was quenched by the Al-GFLX complex via a photoinduced electron transfer (PET) mechanism...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28693733/a-fluorescent-dyad-with-large-emission-shift-for-discrimination-of-cysteine-homocysteine-from-glutathione-and-hydrogen-sulfide-and-the-application-of-bioimaging
#20
Xueling Yang, Longwei He, Kaixin Xu, Weiying Lin
Biothiols, as reactive sulfur species (RSS), play important roles in human physiology, and they have a close connection of generation and metabolism pathways among of them. It is challenging to discriminate biothiols from each other due to the similar chemical structures and properties of them. Herein, we develop a fluorescent hybrid dyad (CS-NBD) for efficiently discriminating cysteine (Cys)/homocysteine (Hcy) from glutathione (GSH) and hydrogen sulfide (H2S) by a dual-channel detection method. CS-NBD performs inherently no fluorescence in ranging from visible to near infrared region...
August 15, 2017: Analytica Chimica Acta
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