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Near-infrared fluorescence imaging

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https://www.readbyqxmd.com/read/28221751/molecular-engineering-and-design-of-semiconducting-polymer-dots-with-narrow-band-near-infrared-emission-for-in-vivo-biological-imaging
#1
Chi-Shiang Ke, Chia-Chia Fang, Jia-Ying Yan, Po-Jung Tseng, Joseph R Pyle, Chuan-Pin Chen, Shu-Yi Lin, Jixin Chen, Xuanjun Zhang, Yang-Hsiang Chan
This article describes the design and synthesis of donor-bridge-acceptor based semiconducting polymer dots (Pdots) that exhibit narrow-band emissions, ultrahigh brightness, and large Stokes shifts in the near-infrared (NIR) region. We systematically investigated the effect of π-bridges on the fluorescence quantum yields of the donor-bridge-acceptor based Pdots. The Pdots could be excited by a 488-nm or 532-nm laser and have a high fluorescence quantum yield of 33% with a Stokes shift over 200 nm. The emission full width at half-maximum of the Pdots can be as narrow as 29 nm, about 2...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28221018/low-efficiency-upconversion-nanoparticles-for-high-resolution-coalignment-of-near-infrared-and-visible-light-paths-on-a-light-microscope
#2
Sriramkumar Sundaramoorthy, Adrian Garcia Badaracco, Sophia M Hirsch, Jun Hong Park, Tim Davies, Julien Dumont, Mimi Shirasu-Hiza, Andrew C Kummel, Julie C Canman
The combination of near-infrared (NIR) and visible wavelengths in light microscopy for biological studies is increasingly common. For example, many fields of biology are developing the use of NIR for optogenetics, in which an NIR laser induces a change in gene expression and/or protein function. One major technical barrier in working with both NIR and visible light on an optical microscope is obtaining their precise coalignment at the imaging plane position. Photon upconverting particles (UCPs) can bridge this gap as they are excited by NIR light but emit in the visible range via an anti-Stokes luminescence mechanism...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28219066/intraoperative-identification-of-colonic-tumor-sites-using-a-near-infrared-fluorescence-endoscopic-imaging-system-and-indocyanine-green
#3
Makoto Watanabe, Masahiko Murakami, Yoshiaki Ozawa, Sota Yoshizawa, Nobuaki Matsui, Takeshi Aoki
BACKGROUND: This study aimed to investigate the feasibility of the PINPOINT® Endoscopic Fluorescence Imaging System (PINPOINT) for intraoperative identification of colonic tumor sites during laparoscopic colorectal surgery. METHODS: Eighty consecutive patients with colorectal cancer were prospectively enrolled. Preoperatively, 0.5 mL of indocyanine green (ICG; 2.5 mg/mL) was injected into the submucosal space only at the distal side of the tumor under colonoscopy...
February 21, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28214496/new-diagnostic-modalities-in-the-evaluation-of-lymphedema
#4
REVIEW
Thomas F O'Donnell, John C Rasmussen, Eva M Sevick-Muraca
OBJECTIVE: Currently, lymphedema (LED) is typically diagnosed clinically on the basis of a patient's history and characteristic physical findings. Whereas the diagnosis of LED is sometimes confirmed by lymphoscintigraphy (LSG), the technique is limited in both its ability to identify disease and to guide therapy. Recent advancements provide opportunities for new imaging techniques not only to assist in the diagnosis of LED, based on anatomic changes, but also to assess contractile function and to guide therapeutic intervention...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214320/indocyanine-green-assisted-sentinel-lymph-node-biopsy-in-melanoma-using-the-fovis-system
#5
Daniela Göppner, Stephan Nekwasil, Anne Jellestad, Alexander Sachse, Karl-Heinz Schönborn, Harald Gollnick
BACKGROUND: Metastatic involvement of the sentinel lymph node (SLN) represents a key prognostic factor in melanoma. The combined use of a radiocolloid (technetium-99m) and blue dye is the gold standard in sentinel lymph node biopsy (SLNB). In this context, near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has been suggested as an alternative. The objective of the present study was to examine the potential advantages of fluorescence-guided SLNB - compared to the conventional method - with respect to the visualization of lymphatic drainage pathways and the SLN...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28213790/optical-see-through-cancer-vision-goggles-enable-direct-patient-visualization-and-real-time-fluorescence-guided-oncologic-surgery
#6
Suman B Mondal, Shengkui Gao, Nan Zhu, LeMoyne Habimana-Griffin, Walter J Akers, Rongguang Liang, Viktor Gruev, Julie Margenthaler, Samuel Achilefu
BACKGROUND: The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS: We evaluated an optical see-through goggle augmented imaging and navigation system (GAINS) for near-infrared, fluorescence-guided surgery. Tumor-bearing mice injected with a near infrared cancer-targeting agent underwent fluorescence-guided, tumor resection...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213277/fluorescence-and-computed-tomography-for-assessing-the-biodistribution-of-sirna-after-intratracheal-application-in-mice
#7
Antonia Geyer, Cornelia Lorenzer, Sebastian Gehrig, Manuela Simlinger, Johannes Winkler, Haider Sami, Manfred Ogris
Pulmonary delivery of nucleic acids opens the possibility for direct treatment of lung diseases, like fibrosis, cancer, and infections. Lung retention and biodistribution of nucleic acids remain important issues for the development of suitable therapeutic approaches. Moreover, monitoring the dynamic biodistribution processes of siRNA after aerosol delivery can help in identifying bottlenecks and optimising therapeutic concepts. We investigated dynamic biodistribution events after intratracheal application of chemically stabilised siRNA labeled with near infrared emitting dye AlexaFluor750 (AF750)...
February 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28209913/rapid-imaging-of-tumor-cell-death-in-vivo-using-the-c2a-domain-of-synaptotagmin-i
#8
André A Neves, Bangwen Xie, Sarah Fawcett, Israt S Alam, Timothy H Witney, Maaike M de Backer, Julia Summers, William Hughes, Sarah McGuire, Dmitry Soloviev, Jodie Miller, William J Howat, De-En Hu, Tiago B Rodrigues, David Y Lewis, Kevin M Brindle
Cell death is an important target for imaging the early response of tumors to treatment. We describe here validation of a phosphatidylserine-binding agent for detecting tumor cell death in vivo based on the C2A domain of Synaptotagmin-I. Methods: The capability of near infrared fluorophore-labeled and 99mTechnetium- and (111)Indium-labeled derivatives of C2Am for imaging tumor cell death, using planar near infrared fluorescence (NIRF) imaging and single photon computed tomography (SPECT) respectively, was evaluated in implanted and genetically engineered mouse models of lymphoma and in a human colorectal xenograft...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28208666/the-mechanisms-and-biomedical-applications-of-an-nir-bodipy-based-switchable-fluorescent-probe
#9
Bingbing Cheng, Venugopal Bandi, Shuai Yu, Francis D'Souza, Kytai T Nguyen, Yi Hong, Liping Tang, Baohong Yuan
Highly environment-sensitive fluorophores have been desired for many biomedical applications. Because of the noninvasive operation, high sensitivity, and high specificity to the microenvironment change, they can be used as excellent probes for fluorescence sensing/imaging, cell tracking/imaging, molecular imaging for cancer, and so on (i.e., polarity, viscosity, temperature, or pH measurement). In this work, investigations of the switching mechanism of a recently reported near-infrared environment-sensitive fluorophore, ADP(CA)₂, were conducted...
February 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208300/near-infrared-probe-based-on-rhodamine-derivative-for-highly-sensitive-and-selective-lysosomal-ph-tracking
#10
Guangle Niu, Panpan Zhang, Weimin Liu, Mengqi Wang, Hongyan Zhang, Jiasheng Wu, Liping Zhang, Pengfei Wang
The development of near-infrared fluorescent probes with low pKa, high selectivity, high photostability, and high sensitivity for lysosomal pH detection is of great importance. In the present work, we developed a novel near-infrared lysosomal pH probe (Lyso-hNR) based on a rhodamine derivative. Lyso-hNR showed fast, highly sensitive, and highly selective fluorescence response to acidic pH caused by the H(+)-induced structure changes from the nonfluorescent spirolactam form to the highly emissive open-ring form...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28205245/the-use-of-near-infrared-fluorescence-imaging-in-endocrine-surgical-procedures
#11
Bora Kahramangil, Eren Berber
Near-infrared fluorescence imaging in endocrine surgery is a new, yet highly investigated area. It involves indocyanine green use as well as parathyroid autofluorescence. Several groups have described their technique and reported on the observed utility. However, there is no consensus on technical details. Furthermore, the correlation between intraoperative findings and postoperative outcomes is unclear. With this study, we aim to review the current literature on fluorescence imaging and share our insights on technical details...
February 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28202518/prolactin-receptor-mediated-internalization-of-imaging-agents-detects-epithelial-ovarian-cancer-with-enhanced-sensitivity-and-specificity
#12
Karthik M Sundaram, Yilin Zhang, Anirban K Mitra, Jean-Louis K Kouadio, Katja Gwin, Brian R Roman, Anthony A Kossiakoff, Ernst Lengyel, Joseph Piccirilli
Poor prognosis of ovarian cancer (OvCa), the deadliest of the gynecologic malignancies, reflects major limitations associated with detection and diagnosis. Current methods lack high sensitivity to detect small tumors and high specificity to distinguish malignant from benign tissue, both impeding diagnosis of early and metastatic cancer stages and leading to costly and invasive surgeries. Tissue microarray analysis revealed that >98% of OvCa express the prolactin receptor (PRLR), forming the basis of a new molecular imaging strategy...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28195369/near-infrared-photoluminescent-polymer-carbon-nanodots-with-two-photon-fluorescence
#13
Siyu Lu, Laizhi Sui, Junjun Liu, Shoujun Zhu, Anmin Chen, Mingxing Jin, Bai Yang
A facile, high-output strategy is developed for fabricating near-infrared-emissive polymer-carbon nanodots (PCNDs). The PCNDs emit at a wavelength of 710 nm with a QY of 26.28%, which is promising for deep biological imaging and luminescent devices. Moreover, the PCNDs possess two-photon fluorescence and. In vivo bioimaging and red light emitting diodes based on these PCNDs are demonstrated.
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28180189/far-red-and-near-infrared-seminaphthofluorophores-for-targeted-pancreatic-cancer-imaging
#14
Lei Wang, Connor W Barth, Martha Sibrian-Vazquez, Jorge O Escobedo, Mark Lowry, John Muschler, Haiyan Li, Summer L Gibbs, Robert M Strongin
Molecular probes that selectively highlight pancreatic cancer (PC) tissue have the potential to improve pancreatic ductal adenocarcinoma (PDAC) margin assessment through the selective highlighting of individual PC cells. Herein, we report a simple and unique family of systematically modified red and near-infrared fluorescent probes that exhibit a field-effect-derived redshift. Two of thirteen probes distributed to the normal mouse pancreas following systemic administration. One selectively accumulated in genetically modified mouse models of PDAC...
January 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28179099/hydrophobically-modified-polysaccharide-based-on-polysialic-acid-nanoparticles-as-carriers-for-anticancer-drugs
#15
Bom Jung, Man-Kyu Shim, Min-Ju Park, Eun Hyang Jang, Hong Yeol Yoon, Kwangmeyung Kim, Jong-Ho Kim
This study presented the development of hydrophobically modified polysialic acid (HPSA) nanoparticles, a novel anticancer drug nanocarrier that increases therapeutic efficacy without causing nonspecific toxicity towards normal cells. HPSA nanoparticles were prepared by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC)/N-hydroxysuccinimide (NHS) coupling between N-deacetylated polysialic acid (PSA) and 5β-cholanic acid. The physicochemical characteristics of HPSA nanoparticles (zeta-potential, morphology and size) were measured, and in vitro cytotoxicity and cellular uptake of PSA and HPSA nanoparticles were tested in A549 cells...
February 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28178882/fluorescent-imaging-with-indocyanine-green-during-laparoscopic-cholecystectomy-in-patients-at-increased-risk-of-bile-duct-injury
#16
Marjolein Ankersmit, Dieuwertje A van Dam, Anne-Sophie van Rijswijk, Baukje van den Heuvel, Jurriaan B Tuynman, Wilhelmus J H J Meijerink
BACKGROUND: Although rare, injury to the common bile duct (CBD) during laparoscopic cholecystectomy (LC) can be reduced by better intraoperative visualization of the cystic duct (CD) and CBD. The aim of this study was to establish the efficacy of early visualization of the CD and the added value of CBD identification, using near-infrared (NIR) light and the fluorescent agent indocyanine green (ICG), in patients at increased risk of bile duct injury. MATERIALS AND METHODS: Patients diagnosed with complicated cholecystitis and scheduled for LC were included...
January 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28177224/protein-stabilized-gadolinium-oxide-gold-nanoclusters-hybrid-for-multimodal-imaging-and-drug-delivery
#17
Lu Han, Jun-Mei Xia, Xin Hai, Yang Shu, Xu-Wei Chen, Jian-Hua Wang
A protein-stabilized multifunctional theranostic nanoplatform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3-AuNCs nanohybrid is developed by integrating Gd2O3 nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance and X-ray computed tomography imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen ((1)O2) upon near-infrared laser stimulation at 808 nm...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28177223/facial-layer-by-layer-engineering-of-upconversion-nanoparticles-for-gene-delivery-nir-initiated-fret-tracking-and-overcoming-drug-resistance-in-ovarian-cancer
#18
Min Lin, Yan Gao, Thomas J Diefenbach, Jacson K Shen, Francis J Hornicek, Yong Il Park, Feng Xu, Tian Jian Lu, Mansoor M Amiji, Zhenfeng Duan
Development of multidrug resistance (MDR) contributes to the majority of treatment failures in clinical chemotherapy. We report facial layer-by-layer engineered upconversion nanoparticles (UCNPs) for near infrared (NIR) initiated tracking and delivery of small interfering RNA (siRNA) to enhance chemotherapy efficacy by silencing the MDR1 gene and re-sensitizing resistant ovarian cancer cells to drug. Layer-by-layer engineered UCNPs were loaded with MDR1 gene-silencing siRNA (MDR1-siRNA) by electrostatic interaction...
February 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28167355/development-of-a-new-bioactivatable-fluorescent-probe-for-quantification-of-apolipoprotein-a-i-proteolytic-degradation-in%C3%A2-vitro-and-in%C3%A2-vivo
#19
Foued Maafi, Baoqiang Li, Catherine Gebhard, Mathieu R Brodeur, Walid Nachar, Louis Villeneuve, Frédéric Lesage, David Rhainds, Eric Rhéaume, Jean-Claude Tardif
BACKGROUND AND AIMS: The potential benefits of high-density lipoproteins (HDL) against atherosclerosis are attributed to its major protein component, apolipoprotein A-I (apoA-I). Most of the apoA-I in the vascular wall appears to be in its lipid-poor form. The latter, however, is subjected to degradation by proteases localized in atherosclerotic plaques, which, in turn, has been shown to negatively impact its atheroprotective functions. Here, we report the development and in vivo use of a bioactivatable near-infrared full-length apoA-I-Cy5...
January 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28166417/detection-of-microspheres-in-vivo-using-multispectral-optoacoustic-tomography
#20
N Bhutiani, C W Kimbrough, N C Burton, S Morscher, M Egger, K McMasters, A Woloszynska-Read, A El-Baz, L R McNally
We introduce a new approach to detect individual microparticles that contain NIR fluorescent dye by multispectral optoacoustic tomography in the context of the hemoglobin-rich environment within murine liver. We encapsulated a near infrared (NIR) fluorescent dye within polystyrene microspheres, then injected them into the ileocolic vein, which drains to the liver. NIR absorption was determined using multispectral optoacoustic tomography. To quantitate the minimum diameter of microspheres, we used both colorimetric and spatial information to segment the regions in which the microspheres appear...
February 6, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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