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Near-infrared fluorescence imaging

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https://www.readbyqxmd.com/read/27928781/mechanism-of-fluorescence-enhancement-of-biosynthesized-xfe2o4-bifeo3-x-cr-mn-co-or-ni-membranes
#1
Liang Bian, Hai-Long Li, Hai-Liang Dong, Fa-Qin Dong, Mian-Xin Song, Li-Sheng Wang, Wen-Ping Hou, Lei Gao, Xiao-Yan Zhang, Tian-Liang Zhou, Guang-Ai Sun, Xin-Xi Li, Lei Xie
Ferrites-bismuth ferrite is an intriguing option for medical diagnostic imaging device due to its magnetoelectric and enhanced near-infrared fluorescent properties. However, the embedded XFO nanoparticles are randomly located on the BFO membranes, making implementation in devices difficult. To overcome this, we present a facile bio-approach to produce XFe2O4-BiFeO3 (XFO-BFO) (X = Cr, Mn, Co, or Ni) membranes using Shewanella oneidensis MR-1. The perovskite BFO enhances the fluorescence intensity (at 660 and 832 nm) and surface potential difference (-469 ~ 385 meV and -80 ~ 525 meV) of the embedded spinel XFO...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27925417/effects-of-temperature-on-multiparametric-evaluation-of-hindlimb-ischemia-with-dynamic-fluorescence-imaging
#2
Wenjuan Cai, Huizhi Guang, Chuangjian Cai, Jianwen Luo
Quantitative evaluation of hindlimb ischemia is essential for early diagnosis and therapy of peripheral arterial disease (PAD). Dynamic imaging using near-infrared (NIR) fluorophore indocyanine green (ICG) is a noninvasive and effective tool to monitor multiple vascular parameters including perfusion rate (PR), perfusion vascular density (PVD) and hemodynamics. It has been previously demonstrated that temperature changes could lead to significant variations of blood flow rate and vascular perfusion. In this paper, multiparametric evaluation of hindlimb ischemia was performed at different temperatures...
December 7, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27924787/controllable-synthesis-of-mn-6-doped-nanoparticles-by-a-facile-anion-exchange-method
#3
Xiaowen Zhang, Yang Li, Chenxing Liao, Zhi Chen, Jianrong Qiu
Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1400 nm) is attracting extensive attention. Mn(6+) doped BaSO4 with broadband emission from 900 nm to 1400 nm is emerging as a new class of NIR phosphor for fluorescence imaging. Manganese has diverse valence states, thus it is difficult to prevent valence change of Mn(6+) during traditional synthesis process. In this work, BaSO4:Mn(6+) nanoparticles with uniform size and morphology were first successfully prepared through a fast liquid-solid solution route at room temperature...
January 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27924162/a-pretargeted-approach-for-the-multimodal-pet-nirf-imaging-of-colorectal-cancer
#4
Pierre Adumeau, Kathryn E Carnazza, Christian Brand, Sean D Carlin, Thomas Reiner, Brian J Agnew, Jason S Lewis, Brian M Zeglis
The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of strategies for the multimodal PET/NIRF imaging of cancer a very enticing prospect. Indeed, in the context of colorectal cancer, a single multimodal PET/NIRF imaging agent could be used to stage the disease, identify candidates for surgical intervention, and facilitate the image-guided resection of the disease. While antibodies have proven to be highly effective vectors for the delivery of radioisotopes and fluorophores to malignant tissues, the use of radioimmunoconjugates labeled with long-lived nuclides such as (89)Zr poses two important clinical complications: high radiation doses to the patient and the need for significant lag time between imaging and surgery...
2016: Theranostics
https://www.readbyqxmd.com/read/27924155/versatile-ph-response-micelles-with-high-cell-penetrating-helical-diblock-copolymers-for-photoacoustic-imaging-guided-synergistic-chemo-photothermal-therapy
#5
Shengyu Shi, Yajing Liu, Yu Chen, Zhihuang Zhang, Yunsheng Ding, Zongquan Wu, Jun Yin, Liming Nie
With high optical absorption efficiency, near infrared (NIR) dyes have been proposed as theranostic agents for fluorescence imaging, photoacoustic imaging (PAI), and photothermal therapy (PTT). However, inherent hydrophobicity and short circulation time of small molecule hinder the further biomedical application. Herein smart amphiphilic copolymer was synthesized containing IR780/camptothecin@poly(ε-caprolactone) (IR780/CPT@PCL) as core, helical poly(phenyl isocyanide) (PPI) blocks as shell with the pH-responsive rhodamine B (RhB) moieties in the core-shell interface...
2016: Theranostics
https://www.readbyqxmd.com/read/27907859/near-infrared-mediated-quantum-dots-and-paclitaxel-co-loaded-nanostructured-lipid-carriers-for-cancer-theragnostic
#6
Livesey David Olerile, Yongjun Liu, Bo Zhang, Tianqi Wang, Shengjun Mu, Jing Zhang, Lesego Selotlegeng, Na Zhang
Timing is an important factor in cancer management. Theragnostic systems have benefit of improving patients' life-quality by expediting therapeutic decisions. The objective of this study was to explore the potential of co-loaded [quantum dots (CdTe/CdS/ZnS) and paclitaxel] NLC (nanostructured lipid carriers) as a parenteral multifunctional delivery system. The co-loaded NLC was prepared by emulsion-evaporation and low temperature-solidification method utilising glyceryl monostearate, oleic acid, and soya phosphatidylcholine as lipid matrix...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27897207/super-resolution-imaging-at-mid-infrared-waveband-in-graphene-nanocavity-formed-on-meta-surface
#7
Jingzhong Yang, Taisheng Wang, Zuolong Chen, Bingliang Hu, Weixing Yu
Plasmonic structured illumination microscopy (PSIM) is one of the promising wide filed optical imaging methods, which takes advantage of the surface plasmons to break the optical diffraction limit and thus to achieve a super-resolution optical image. To further improve the imaging resolution of PSIM, we propose in this work a so called graphene nanocavity on meta-surface structure (GNMS) to excite graphene surface plasmons with a deep sub-wavelength at mid-infrared waveband. It is found that surface plasmonic interference pattern with a period of around 52 nm can be achieved in graphene nanocavity formed on structured meta-surface for a 7 μm wavelength incident light...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884637/phototheranostic-nanoplatform-based-on-a-single-cyanine-dye-for-image-guided-combinatorial-phototherapy
#8
Tony Duong, Xiaoning Li, Bona Yang, Canan Schumann, Hassan A Albarqi, Olena Taratula, Oleh Taratula
This study represents a novel phototheranostic nanoplatform based on the near-infrared (NIR) heptamethine cyanine dye, IR775, which is capable of concurrent real-time fluorescence imaging and cancer eradication with combinatorial phototherapy. To achieve water solubility and enhance tumor delivery, the hydrophobic IR775 dye was loaded into a biocompatible polymeric nanoparticle with a diameter of ~40nm and slightly negative surface charge (-2.34mV). The nanoparticle-encapsulated hydrophobic IR775 dye (IR775-NP) is characterized by an enhanced fluorescence quantum yield (16%) when compared to the water soluble analogs such as ICG (2...
November 21, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27877897/quantitative-evaluation-of-malignant-gliomas-damage-induced-by-photoactivation-of-ir700-dye
#9
Morito Sakuma, Sayaka Kita, Hideo Higuchi
The processes involved in malignant gliomas damage were quantitatively evaluated by microscopy. The near-infrared fluorescent dye IR700 that is conjugated to an anti-CD133 antibody (IR700-CD133) specifically targets malignant gliomas (U87MG) and stem cells (BT142) and is endocytosed into the cells. The gliomas are then photodamaged by the release of reactive oxygen species (ROS) and the heat induced by illumination of IR700 by a red laser, and the motility of the vesicles within these cells is altered as a result of cellular damage...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877887/in-vitro-biomechanical-properties-fluorescence-imaging-surface-enhanced-raman-spectroscopy-and-photothermal-therapy-evaluation-of-luminescent-functionalized-camoo4-eu-au-hybrid-nanorods-on-human-lung-adenocarcinoma-epithelial-cells
#10
Qifei Li, Abdul K Parchur, Anhong Zhou
Highly dispersible Eu(3+)-doped CaMoO4@Au-nanorod hybrid nanoparticles (HNPs) exhibit optical properties, such as plasmon resonances in the near-infrared region at 790 nm and luminescence at 615 nm, offering multimodal capabilities: fluorescence imaging, surface-enhanced Raman spectroscopy (SERS) detection and photothermal therapy (PTT). HNPs were conjugated with a Raman reporter (4-mercaptobenzoic acid), showing a desired SERS signal (enhancement factor 5.0 × 10(5)). The HNPs have a heat conversion efficiency of 25...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877237/near-infrared-fluorescent-nanoparticles-derived-from-hyaluronic-acid-improve-tumor-contrast-for-image-guided-surgery
#11
Tanner K Hill, Sneha S Kelkar, Nicholas E Wojtynek, Joshua J Souchek, William M Payne, Kristina Stumpf, Frank C Marini, Aaron M Mohs
Tumor tissue that remains undetected at the primary surgical site can cause tumor recurrence, repeat surgery, and treatment strategy alterations that impose a significant patient and healthcare burden. Intraoperative near infrared fluorescence (NIRF) imaging is one potential method to identify remaining tumor by visualization of NIR fluorophores that are preferentially localized to the tumor. This requires development of fluorophores that consistently identify tumor tissue in different patients and tumor types...
2016: Theranostics
https://www.readbyqxmd.com/read/27877038/sulfonate-modified-phenylboronic-acid-rich-nanoparticles-as-a-novel-mucoadhesive-drug-delivery-system-for-vaginal-administration-of-protein-therapeutics-improved-stability-mucin-dependent-release-and-effective-intravaginal-placement
#12
ChunYan Li, ZhiGang Huang, ZheShuo Liu, LiQian Ci, ZhePeng Liu, Yu Liu, XueYing Yan, WeiYue Lu
Effective interaction between mucoadhesive drug delivery systems and mucin is the basis of effective local placement of drugs to play its therapeutic role after mucosal administration including vaginal use, which especially requires prolonged drug presence for the treatment of gynecological infectious diseases. Our previous report on phenylboronic acid-rich nanoparticles (PBNPs) demonstrated their strong interaction with mucin and mucin-sensitive release profiles of the model protein therapeutics interferon (IFN) in vitro, but their poor stability and obvious tendency to aggregate over time severely limited future application...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27868394/sensitivity-and-accuracy-of-hybrid-fluorescence-mediated-tomography-in-deep-tissue-regions
#13
Stefanie Rosenhain, Wa'el Al Rawashdeh, Fabian Kiessling, Felix Gremse
Fluorescence-mediated tomography (FMT) enables noninvasive assessment of the three-dimensional distribution of near-infrared fluorescence in mice. The combination with micro-computed tomography (µCT) provides anatomical data, enabling improved fluorescence reconstruction and image analysis. The aim of our study was to assess sensitivity and accuracy of µCT-FMT under realistic in vivo conditions in deeply-seated regions. Accordingly, we acquired fluorescence reflectance images (FRI) and µCT-FMT scans of mice which were prepared with rectal insertions with different amounts of fluorescent dye...
November 21, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27867728/label-free-measurement-of-retinal-blood-cell-flux-velocity-hematocrit-and-capillary-width-in-the-living-mouse-eye
#14
A Guevara-Torres, A Joseph, J B Schallek
Measuring blood cell dynamics within the capillaries of the living eye provides crucial information regarding the health of the microvascular network. To date, the study of single blood cell movement in this network has been obscured by optical aberrations, hindered by weak optical contrast, and often required injection of exogenous fluorescent dyes to perform measurements. Here we present a new strategy to non-invasively image single blood cells in the living mouse eye without contrast agents. Eye aberrations were corrected with an adaptive optics camera coupled with a fast, 15 kHz scanned beam orthogonal to a capillary of interest...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27865020/nitrogen-induced-transformation-of-vitamin-c-into-multifunctional-up-converting-carbon-nanodots-in-the-visible-nir-range
#15
M Carmen Ortega-Liebana, M Mar Encabo-Berzosa, M Jose Ruedas-Rama, Jose Luis Hueso
Water-soluble, biocompatible, and photoluminescent carbon nanodots have been obtained from the rationalized carbonization of vitamin C, a well-known antioxidant molecule in the presence of an amine co-reactant. Herein, we describe the positive influence of N-doping to induce a unique pH-dependent lifetime decay response that would be potentially attractive in biological backgrounds with intrinsic fluorescence fluctuations. In addition, the selectivity and sensitivity of the N-containing carbon nanoprobes towards the detection of copper ions at ppm levels is critically enhanced in comparison with the un-doped counterpart, especially in the near-infrared (NIR) range...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27862961/identification-of-a-glypican-3-binding-peptide-for-in-vivo-non-invasive-human-hepatocellular-carcinoma-detection
#16
Zainen Qin, Jingjing Wang, Ye Wang, Guohao Wang, Xiangyu Wang, Zhiyang Zhou, Gang Liu, Shi Gao, Lei Zhu
Early and accurate detection of hepatocellular carcinoma (HCC) is essential to improve the prognosis of patients and reduce the morbidity of surgical therapy. Glypican-3 (GPC3) is a protein abnormally expressed in HCC that has been identified as a serological and histochemical HCC marker. A novel peptide that specifically recognizes GPC3 will facilitate early detection of HCC and guide the treatment strategy. Herein, phage display screening technology is utilized to obtain a GPC3 binding peptide (GBP) using HCC cells expressing GPC3 in varying abundances...
November 15, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#17
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27859805/epicocconone-hemicyanine-hybrids-near-infrared-fluorophores-for-protein-staining-and-cell-imaging
#18
Xavier Franck, Peter Karuso, Wendy Loa Kum Cheung, Philippe Peixoto, Agathe Boulange
The development of new Near Infra-Red (NIR) dyes is crucial for diverse applications and especially bioimaging, as they absorb and emit light in the 'therapeutic window' (650-950 nm). We report here a new family of NIR fluorophores that has been obtained by hybridizing hemicyanines with epicocconone. Emission wavelengths of these hybrid dyes is in the range 715-795 nm and is combined with large Stokes' shifts (75-95 nm). The absorption and emission wavelength can be modulated according to the hemicyanine moiety and adding sulfonic acid moieties enhances water solubility...
November 11, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27858361/high-resolution-intravital-microscopy-of-tumor-angiogenesis
#19
Ann L B Seynhaeve, Timo L M Ten Hagen
Real-time evaluation of vascular effects in an animal skinfold window model by intravital microscopy (IVM) provides a powerful tool to improve insight into vascular development and vascular therapy. The potential of IVM to examine processes in tissues (e.g., tumors, inflammatory sites), in a noninvasive way, enables determination of the kinetics of processes under study at any given time point. The introduction of sensitive digital cameras, confocal and multiphoton microscopy, and powerful imaging software greatly improved the quality of the images acquired...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27857208/bright-blue-shifted-fluorescent-proteins-with-cys-in-the-gaf-domain-engineered-from-bacterial-phytochromes-fluorescence-mechanisms-and-excited-state-dynamics
#20
Yusaku Hontani, Daria M Shcherbakova, Mikhail Baloban, Jingyi Zhu, Vladislav V Verkhusha, John T M Kennis
Near-infrared fluorescent proteins (NIR FPs) engineered from bacterial phytochromes (BphPs) are of great interest for in vivo imaging. They utilize biliverdin (BV) as a chromophore, which is a heme degradation product, and therefore they are straightforward to use in mammalian tissues. Here, we report on fluorescence properties of NIR FPs with key alterations in their BV binding sites. BphP1-FP, iRFP670 and iRFP682 have Cys residues in both PAS and GAF domains, rather than in the PAS domain alone as in wild-type BphPs...
November 18, 2016: Scientific Reports
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