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Near-infrared fluorescence imaging

Jingli Hou, Meng Qian, Huanhuan Zhao, Yingchun Li, Yongfang Liao, Guifang Han, Zhelong Xu, Feng Wang, Yuguang Song, Yangping Liu
Much attention has been paid to develop optical probes for noninvasive, quantitative, in vivo monitoring of hydrogen peroxide (H2 O2 ) due to its important roles in the initiation and development of numerous diseases. Motivated to meet this need, we herein report the synthesis of a near-infrared (NIR) fluorescent probe (AB1) for H2 O2 by modulating intramolecular charge transfer (ICT) process of the dye 9H-1,3-Dichloro-7-hydroxy-9,9-dimethylacridine-2-one (DDAO). The probe AB1 exhibits both a large NIR fluorescence turn-on and a ratiometric response to H2 O2 with high sensitivity and specificity...
September 18, 2018: Analytica Chimica Acta
Wen Liu, Yalun Wang, Xiao Han, Ping Lu, Liang Zhu, Chaowei Sun, Jun Qian, Sailing He
Near-infrared (NIR) fluorescence is very important for high-contrast biological imaging of high-scattering tissues such as brain tissue. Unfortunately, commercial NIR dyes are excited usually by visible light, and their multi-photon absorption (MPA) cross-sections are small. Here, we design new co-encapsulated NIR nanoparticles (NPs) with a large three-photon (3PA) absorption cross-section. A form of aggregation-induced emission (AIE) luminogen (AIEgen), 2,3-bis(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl) fumaronitrile (TPATCN), is introduced as the donor, and a form of NIR dye, silicon 2,3-naphthalocyanine bis-(trihexylsilyloxide) (NIR775), is adopted as the acceptor...
May 18, 2018: Nanoscale
Sohrab Arora, Craig Rogers
Nephron-sparing surgery, especially through a minimally invasive approach, is increasingly being performed for incidentally detected renal masses with excellent outcomes. Tumors in central location remain a surgical challenge during nephron-sparing surgery. In this chapter, we discuss the minimally invasive management of these tumors, which include complex hilar tumors and endophytic central tumors, with a focus on surgical technique. The key to management of these tumors is to maintain good preoperative hydration, achieving adequate exposure of tumor, and the use of intraoperative ultrasound to plan the resection plane...
May 2018: Journal of Endourology
Cheong A Choi, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Young Kwang Kim, Insik In, Ji Hoon Jeong, Sung Young Park
We described fluorescence resonance energy transfer for pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions in cancer therapy. The capability for fluorescence bioimaging was achieved via the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds were reduced and benzoic imine were cleaved under acidic conditions...
May 18, 2018: ChemMedChem
Duyang Gao, Yubin Liu, Yating Wang, Zhen Yuan
Background: Construction of nanoprobes for dual-modal fluorescence/photoacoustic imaging (PAI) is of great importance for the detection of disease pathology and the development of innovative therapeutics. Previously ultra-small gold clusters were designed and used as contrast agents for fluorescence imaging (FLI). However, it is not clear whether they can also serve as promising probes for PAI. In this study, protein-modified ultra-small gold clusters are produced and examined quantitatively as enhanced contrast agents for dual-modal in vivo fluorescence and PAI...
April 2018: Quantitative Imaging in Medicine and Surgery
Tung Nguyen Thanh Uong, Kyung-Hwa Lee, Sung-Ja Ahn, Kyung Won Kim, Jung-Joon Min, Hoon Hyun, Mee Sun Yoon
Introduction: Ex vivo -expanded natural killer (NK) cells are a potential candidate for cancer immunotherapy based on high cytotoxicity against malignant tumor cells. However, a limited understanding of the migration of activated NK cells toward solid tumors is a critical dilemma in the development of effective and adoptive NK cell-based immunotherapy. Methods: Ex vivo -expanded NK cells from healthy donors were stained with near-infrared fluorophores at different concentrations...
2018: Frontiers in Immunology
Xinggui Gu, Xiaoyan Zhang, Huili Ma, Shaorui Jia, Pengfei Zhang, Yanjun Zhao, Qian Liu, Jianguo Wang, Xiaoyan Zheng, Jacky W Y Lam, Dan Ding, Ben Zhong Tang
Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced emission characteristic (AIEgens), namely AIE dots, have received wide attention because of their antiquenching attitude in emission and reactive oxygen species (ROS) generation when aggregated. However, few reports are available on how to control and optimize their fluorescence and ROS generation ability. Herein, it is reported that enhancing the intraparticle confined microenvironment is an effective approach to advanced AIE dots, permitting boosted cancer phototheranostics in vivo...
May 16, 2018: Advanced Materials
Yukun Cheng, Ling Li, Fangfang Wei, Keith Man-Chung Wong
The synthesis and characterization of a platinum(II) terpyridine system tethered with a latent organic dye of rhodamine derivative as colorimetric and luminescent sensory moiety is reported to show selective Hg2+ ion sensing behavior. The interplay of aggregation/deaggregation behavior of the alkynylplatinum(II) terpyridine complex and the ring-opening process of rhodamine derivative was investigated. The spectral change of aggregation near-infrared emission at 800 nm and rhodamine fluorescence at 585 nm provides a possible ratiometric luminescence measurement...
May 15, 2018: Inorganic Chemistry
Xinyu Wang, Junjie Yan, Donghui Pan, Runlin Yang, Lizhen Wang, Yuping Xu, Jie Sheng, Yuanyuan Yue, Qianhuan Huang, Yanting Wang, Rongrong Wang, Min Yang
Self-assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol and poloxamer self-assemble supramolecular nanoparticles (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid and Pluronic F-127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied in tumor near-infrared fluorescence (NIRF) imaging and positron emission tomography (PET) imaging. With near-infrared fluorescent dyes such as IR780 encapsulated via hydrophobic interactions, PPNPs are used in NIRF imaging...
May 14, 2018: Advanced Healthcare Materials
Zhenyue Chen, Xosé Luís Deán-Ben, Sven Gottschalk, Daniel Razansky
Fluorescent contrast agents are widely employed in biomedical research. While many studies have reported deep tissue imaging of fluorescent moieties using either fluorescence-based or absorption-based (optoacoustic) imaging systems, no systematic comparison has been performed regarding the actual performance of these imaging modalities in detecting deep-seated fluorescent agents. Herein, an integrated imager combining epi-fluorescence and volumetric optoacoustic imaging capabilities has been employed in order to evaluate image degradation with depth for several commonly-used near-infrared dyes in both modes...
May 1, 2018: Biomedical Optics Express
Jorge A Benitez, Ciro Zanca, Jianhui Ma, Webster K Cavenee, Frank B Furnari
Tumorigenicity is the capability of cancer cells to form a tumor mass. A widely used approach to determine if the cells are tumorigenic is by injecting immunodeficient mice subcutaneously with cancer cells and measuring the tumor mass after it becomes visible and palpable. Orthotopic injections of cancer cells aim to introduce the xenograft in the microenvironment that most closely resembles the tissue of origin of the tumor being studied. Brain cancer research requires intracranial injection of cancer cells to allow the tumor formation and analysis in the unique microenvironment of the brain...
April 26, 2018: Journal of Visualized Experiments: JoVE
Xiaoyi Wang, Jie Min, Weijie Wang, Yan Wang, Gui Yin, Ruiyong Wang
Reactive oxygen species (ROS), especially HOCl/ClO-, have been demonstrated to play essential roles in both physiological and pathological processes, and an abnormal level of HOCl/ClO- is related to some diseases. In this work, a very fast responsive (within 30 seconds) porphyrin-based fluorescent probe, TPP-TCF, for ClO- with a NIR emissive wavelength was prepared. This probe exhibited excellent selectivity towards ClO- and would not be interfered with by other ROS and typical nucleophiles. The limit of detection (LOD) for ClO- was evaluated to be 0...
May 14, 2018: Analyst
Mathew T Hembury, Nataliia Beztsinna, Hamed Asadi, Joep van den Dikkenberg, Johannes D Meeldijk, Wim E Hennink, Tina Vermonden
Ultrasmall gold atom clusters (< 2 nm in diameter) or gold nanoclusters exhibit emergent photonic properties (near-infrared absorption and emission) compared to larger plasmonic gold particles, due to the significant quantization of their conduction band. While single gold nanoclusters properties and applications are being increasingly investigated, little is still known about their behaviour and properties when assembled into suprastructures and even less studies are investigating their use for biomedical applications...
May 11, 2018: Biomacromolecules
Yushen Jin, Xin Yang, Jie Tian
Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i...
May 10, 2018: Nanoscale
Matthias van Oosterom, David den Houting, Cornelis van de Velde, Fijs van Leeuwen
Fluorescence guidance facilitates real-time intraoperative visualization of the tissue of interest. However, due to attenuation, the application of fluorescence guidance is restricted to superficial lesions. To overcome this shortcoming, we have previously applied three-dimensional surgical navigation to position the fluorescence camera in reach of the superficial fluorescent signal. Unfortunately, in open surgery, the near-infrared (NIR) optical tracking system (OTS) used for navigation also induced an interference during NIR fluorescence imaging...
May 2018: Journal of Biomedical Optics
Masahiro Takada, Megumi Takeuchi, Eiji Suzuki, Fumiaki Sato, Yoshiaki Matsumoto, Masae Torii, Nobuko Kawaguchi-Sakita, Hiroto Nishino, Satoru Seo, Etsuro Hatano, Masakazu Toi
BACKGROUND: Inability to visualize indocyanine green fluorescence images in the surgical field limits the application of current near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node (SLN) biopsy in breast cancer patients. The aim of this study was to evaluate the usefulness of the Medical Imaging Projection System (MIPS), which uses active projection mapping, for SLN biopsy. METHODS: A total of 56 patients (59 procedures) underwent SLN biopsy using the MIPS between March 2016 and November 2017...
May 9, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Hiroshi Yukawa, Yoshinobu Baba
Quantum dots (QDs) have excellent fluorescence properties in comparison to traditional fluorescence probes. Thus, the optical application of QDs is rapidly expanding to each field of analytical chemistry. In this review paper, we reviewed the application of QDs to regenerative medicine, especially stem cell transplantation therapy. The labeling of stem cells using QDs composed of semiconductor materials in combination with a chemical substance, poly-cationic liposome and cell penetrating peptide is reported...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Zhiming Deng, Xiaolong Li, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng, Hongrong Liu
Optical bioimaging that works in the second near infrared region (NIR-II, 1000-1700 nm) has emerged as a next generation imaging technique with superior imaging sensitivity and spatial resolution compared to traditional optical imaging utilizing visible and near-infrared lights (below 900 nm). Herein, a new Sc-based NIR-II probe was explored for high performance NIR-II in vivo bioimaging and optical imaging-guided non-invasive brain blood vessel visualization. The lanthanide doped Sc-based probes (KSc2F7:Yb3+/Er3+) possess a pure orthorhombic phase structure with size control by adjusting the F- ion content...
May 9, 2018: Nanoscale
Zhongqiang Li, Shaomian Yao, Jian Xu, Ye Wu, Chunhong Li, Ziying He
Current dental diagnosis, especially tooth abnormalities, relies largely on X-ray-based imaging, a technique that requires specialized skills and suffers from ionizing radiation. Here, we present a pilot study in rats of an efficient, ionizing-radiation-free and easy-to-use alternative for dental imaging. Postnatal rats at different ages were injected with indocyanine green and molars were imaged by a laboratory-designed endoscopic near-infrared (NIR) dental imaging system. The results indicate that the endoscopic NIR dental imaging can be used to observe the morphology of postnatal rat molars, especially at early postnatal stages when morphology of the molar is indistinguishable under visible conditions...
May 8, 2018: Annals of the New York Academy of Sciences
Lu-Mao Huang, Pei-Yan DU, Lan Chen, Sa Zhang, Di-Fu Zhou, Chun-Lin Chen, Xue-Gang Xin
OBJECTIVE: To develop a near-infrared fluorescence imaging system based on the fluorescence properties of methylene blue. METHODS: According to the optical properties of methylene blue, we used a custom-made specific LED light source and an interference filter, a CCD camera and other relevant components to construct the near-infrared fluorescence imaging system. We tested the signal-to-background ratio (SBR) of this imaging system for detecting methylene blue under different experimental conditions and analyzed the SBR in urine samples collected from 15 Wistar rats with intravenous injection of methylene blue at the doses of 0, 1...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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