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Near-infrared fluorescence imaging

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https://www.readbyqxmd.com/read/28635650/the-application-of-heptamethine-cyanine-dye-dz-1-and-indocyanine-green-for-imaging-and-targeting-in-xenograft-models-of-hepatocellular-carcinoma
#1
Caiqin Zhang, Yong Zhao, He Zhang, Xue Chen, Ningning Zhao, Dengxu Tan, Hai Zhang, Changhong Shi
Near infrared fluorescence (NIRF) imaging has strong potential for widespread use in noninvasive tumor imaging. Indocyanine green (ICG) is the only Food and Drug Administration (FDA) -approved NIRF dye for clinical diagnosis; however, it is unstable and poorly targets tumors. DZ-1 is a novel heptamethine cyanine NIRF dye, suitable for imaging and tumor targeting. Here, we compared the fluorescence intensity and metabolism of DZ-1 and ICG. Additionally, we assayed their specificities and abilities to target tumor cells, using cultured hepatocellular carcinoma (HCC) cell lines, a nude mouse subcutaneous xenograft model of liver cancer, and a rabbit orthotopic transplantation model...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28633520/ion-selective-nanosensor-for-photoacoustic-and-fluorescence-imaging-of-potassium
#2
Chang Heon Lee, Jeff Folz, Wuliang Zhang, Janggun Jo, Joel W Y Tan, Xueding Wang, Raoul Kopelman
Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly important role in chemical and biochemical analysis. Here we extend this technique to ion-selective photo-acoustic optodes (ISPAOs) that serve at the same time as fluorescence-based ISOs, and apply it specifically to potassium (K+). Notably, the potassium ion is one of the most abundant cations in biological systems, involved in numerous physiological and pathological processes. Furthermore, it has been recently reported that the presence of abnormal extracellular potassium concentrations in tumors suppresses the immune responses and thus suppresses immunotherapy...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#3
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
June 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28628303/folate-and-heptamethine-cyanine-modified-chitosan-based-nanotheranostics-for-tumor-targeted-near-infrared-fluorescence-imaging-and-photodynamic-therapy
#4
Yingying Zhang, Tingting Lv, Huijuan Zhang, Xiaodong Xie, Ziying Li, Haijun Chen, Yu Gao
Folate (FA) and heptamethine cyanine (Cy7)-modified chitosan (CF7) was synthesized by click chemistry and its self-assembled nanoparticles (CF7Ns) were developed for tumor-specific imaging and photodynamic therapy. The characterization spectrum confirmed CF7 had a good FA and Cy7 conjugation efficacy. The diameter of CF7Ns measured by DLS was about 291.6 nm and the morphology observed with AFM showed filamentous clusters of particles. The results of targeting ability of CF7Ns demonstrated enhanced targeting behaviors of CF7Ns compared with non-FA-modified nanoparticles C7Ns in FA receptor-positive HeLa cells...
June 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28627326/triphenylamines-induce-cell-death-upon-2-photon-excitation
#5
Rahima Chennoufi, Florence Mahuteau-Betzer, Patrick Tauc, Marie-Paule Teulade-Fichou, Eric Deprez
Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal doses to induce cell death. One drawback of current PDT is the use of visible light which has poor penetration in tissues. Such a limitation could be overcome by the use of novel organic compounds compatible with photoactivation under near-infrared light excitation. Triphenylamines (TPAs) are highly fluorescent compounds that are efficient to induce cell death upon visible light excitation (458 nm), but outside the biological spectral window...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28624825/intraoperative-real-time-assessment-of-liver-function-with-near-infrared-fluorescence-imaging
#6
Hajime Narasaki, Takehiro Noji, Hideyuki Wada, Yuma Ebihara, Takahiro Tsuchikawa, Keisuke Okamura, Eiichi Tanaka, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult. Near-infrared (NIR) fluorescence imaging allows quantitative assessment of the fluorescent signal from indocyanine green (ICG) in regions of interest on the liver surface. This method might offer a new promising modality for evaluating regional liver reserve. However, data are lacking regarding the relationship between liver function and fluorescent signals on the liver surface after intravenous ICG injection...
June 17, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28623992/near-infrared-fluorescence-lymphatic-imaging-of-klippel-tr%C3%A3-naunay-syndrome
#7
John C Rasmussen, Rodrick C Zvavanjanja, Melissa B Aldrich, Matthew R Greives, Eva M Sevick-Muraca
The relationship between lymphatic and venous malformations in Klippel-Trénaunay syndrome is difficult to assess. Herein the authors describe near-infrared fluorescence lymphatic imaging to assess the lymphatics of a subject with a large port-wine stain and right leg edema. Although lymphatic vessels in the medial, affected knee appeared dilated and perhaps tortuous, no definitive abnormal lymphatic pooling or propulsion was observed. The lymphatics in the affected limb were well defined but less numerous than in the contralateral limb, and active, contractile function was observed in all vessels...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28616962/size-dependent-translocation-of-nanoemulsions-via-oral-delivery
#8
Fei Xia, Wufa Fan, Sifan Jiang, Yuhua Ma, Yi Lu, Jianping Qi, Ejaj Ahmad, Xiaochun Dong, Weili Zhao, Wei Wu
The in vivo translocation of nanoemulsions was tracked by imaging tools with emphasis on the size effect. To guarantee accurate identification of nanoemulsions in vivo, water-quenching environment-responsive near-infrared fluorescent probes were used to label nanoemulsions. Imaging evidence confirms prominent digestion in gastrointestinal tract and oral absorption of integral nanoemulsions that survive digestion by enteric epithelia in a size-dependent way. In general, reducing particle size leads to slowed in vitro lipolysis and in vivo digestion, prolonged lifetime in small intestine, increased enteric epithelial uptake, and enhanced transportation to various organs...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28613828/reversible-ratiometric-fluorescent-probe-for-sensing-bisulphate-h2o2-and-its-application-in-zebrafish
#9
Weijie Zhang, Tao Liu, Fangjun Huo, Peng Ning, Xiangming Meng, Caixia Yin
Herein, a novel near-infrared fluorescent probe for ratiometric detection of bisulphate was designed and developed based on a conjugation of naphthopyran-benzothiazolium system. The sensor showed excellent selectivity, high sensitivity and a rapid response toward bisulfite in aqueous solution. Upon the addition of HSO3-, the sensor displayed 37-fold (I520/I630) fluorescence intensity enhancement, accompanied with an apparent color change from violet to colorless, suggesting that the sensor can be used to detect HSO3- with "naked-eye"...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28613824/a-multifunctional-tunable-mof-materials-platform-for-bio-imaging-applications
#10
Dorina F Sava Gallis, Lauren E Shea-Rohwer, Mark A Rodriguez, Meghan C Barnhart-Dailey, Kimberly S Butler, Ting S Luk, Jerilyn A Timlin, Karena W Chapman
Herein we describe a novel multifunctional metal-organic framework (MOF) materials platform that displays both porosity and tunable emission properties as a function of the metal identity (Eu, Nd, and tuned compositions of Nd/Yb). Their emission collectively spans the deep red to near-infrared (NIR) spectral region (~ 614 - 1350 nm), which is highly relevant for in vivo bio-imaging. These new materials meet important prerequisites as relevant to biological processes: they are minimally toxic to living cells, and retain structural integrity in water and phosphate buffered saline...
June 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28610874/on-nylon-membrane-detection-of-nucleic-acid-molecules-by-rolling-circle-amplification
#11
Xinhui Xu, Beibei Zhang, Ping Gan, Jian Wu, Wei Dai, Ling Zhang, Jinke Wang
Positively-charged nylon membrane (NM) is a general solid-phase support for nucleic acid detection due to its convenient immobilization of nucleic acid materials by direct electrostatic adherence and simple UV crosslinking. Rolling circle amplification (RCA) is a widely used isothermal DNA amplification technique for nucleic acid detection. Near-infrared fluorescence (NIRF) is a new fluorescence technique with high sensitivity due to low background. This study developed a simple method for detecting nucleic acid molecules by combining the advantages of NM, RCA and NIRF, named NIRF-based solid phase RCA on nylon membrane (NM-NIRF-sRCA)...
June 10, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28610486/resveratrol-loaded-glycyrrhizic-acid-conjugated-human-serum-albumin-nanoparticles-wrapping-resveratrol-nanoparticles-preparation-characterization-and-targeting-effect-on-liver-tumors
#12
Mingfang Wu, Bolin Lian, Yiping Deng, Ziqi Feng, Chen Zhong, Weiwei Wu, Yannian Huang, Lingling Wang, Chang Zu, Xiuhua Zhao
In this study, glycyrrhizic acid-conjugated human serum albumin nanoparticles wrapping resveratrol nanoparticles were prepared to establish a tumor targeting nano-sized drug delivery system. Glycyrrhizic acid was coupled to human serum albumin, and resveratrol was encapsulated in glycyrrhizic acid-conjugated human serum albumin by high-pressure homogenization emulsification. The average particle size of sample nanoparticles prepared under the optimal conditions was 108.1 ± 5.3 nm with a polydispersity index (PDI) of 0...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28601576/real-time-monitoring-of-microdistribution-of-antibody-photon-absorber-conjugates-during-photoimmunotherapy-in-vivo
#13
Qinggong Tang, Tadanobu Nagaya, Yi Liu, Jonathan Lin, Kazuhide Sato, Hisataka Kobayashi, Yu Chen
Photoimmunotherapy (PIT) is an emerging low side effect cancer therapy based on a monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye IRDye 700DX. IR700 is fluorescent, can be used as an imaging agent, and also is phototoxic. It induces rapid cell death after exposure to NIR light. PIT induces highly selective cancer cell death, while leaving most of tumor blood vessels unharmed, leading to an effect called super-enhanced permeability and retention (SUPR). SUPR significantly improves the effectiveness of the anticancer drug...
June 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28599362/determination-of-phytoplankton-abundances-chlorophyll-a-in-the-optically-complex-inland-water-the-baltic-sea
#14
Daoxi Zhang, Samantha Lavender, Jan-Peter Muller, David Walton, Bengt Karlson, Johan Kronsell
A novel approach, termed Summed Positive Peaks (SPP), is proposed for determining phytoplankton abundances (Chlorophyll-a or Chl-a) and surface phytoplankton bloom extent in the optically complex Baltic Sea. The SPP approach is established on the basis of a baseline subtraction method using Rayleigh corrected top-of-atmosphere data from the Medium Resolution Imaging Spectrometer (MERIS) measurements. It calculates the reflectance differences between phytoplankton related signals observed in the MERIS red and near infrared (NIR) bands, such as sun-induced chlorophyll fluorescence (SICF) and the backscattering at 709nm, and considers the summation of the positive line heights for estimating Chl-a concentrations...
June 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28599305/heptamethine-carbocyanine-dz-1-dye-for-near-infrared-fluorescence-imaging-of-hepatocellular-carcinoma
#15
Jiaze An, Ningning Zhao, Caiqin Zhang, Yong Zhao, Dengxu Tan, Ya Zhao, Bing Bai, Hai Zhang, Boyang Jason Wu, Changhong Shi
Nar-infrared fluorescence (NIRF) dyes have recently emerged as promising tools for non-invasive imaging of different types of cancers. Heree, we explored the potential utility of a NIRF DZ-1 dye, with dual imaging and tumour targeting functions, in hepatocellular carcinoma (HCC). We showed the preferential uptake of DZ-1 by HCC cells in vitro and in derived subcutaneous/orthotopic tumour xenografts, accompanied by a minimal effect on normal cells. DZ-1 simplified tumour growth profiling as well, since we were able to correlate NIRF signals with tumour volume and/or tumour-emitting luminescence in mice...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28591737/characteristics-of-ovarian-cancer-detection-by-a-near-infrared-fluorescent-probe-activated-by-human-nad-p-h-quinone-oxidoreductase-isozyme-1-hnqo1
#16
Yuko Nakamura, Zhenhua Shen, Toshiko Harada, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Peter L Choyke, Robin L McCarley, Hisataka Kobayashi
Near-infrared (NIR) fluorescent probes are ideal for in vivo imaging, because they offer deeper tissue penetration by the light and lower background autofluorescence than fluorophores that emit in the visible range. Q3STCy is a newly synthesized, NIR light-emitting probe that is activated by an enzyme commonly overexpressed in tumor cells, human nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase isozyme 1, known as hNQO1 or DT-diaphorase. The purpose of this study is to compare the sensitivity of detecting peritoneal ovarian cancer metastasis (POCM) with Q3STCy and gGlu-HMRG, a green fluorescent probe, upon their surface application...
May 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28590411/a-conjugate-of-pentamethine-cyanine-and-18-f-as-a-positron-emission-tomography-near-infrared-fluorescence-probe-for-multimodality-tumor-imaging
#17
Fei-Fei An, Harikrishna Kommidi, Nandi Chen, Richard Ting
The novel synthesis of a dual-modality, pentamethine cyanine (Cy5) fluorescent, (18)F positron emission tomography (PET) imaging probe is reported. The probe shows a large extinction coefficient and large quantum yield in the biologically transparent, near-infrared window (650-900 nm) for in vivo fluorescent imaging. This fluorophore bears the isotope, (18)F, giving a (18)F-PET/near-infrared fluorescent (NIRF), bi-modal imaging probe, that combines the long-term stability of NIRF and the unlimited penetration depth of PET imaging...
June 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28587158/low-symmetry-mixed-fluorinated-subphthalocyanines-as-fluorescence-imaging-probes-in-mda-mb-231-breast-tumor-cells
#18
Katherine J McAuliffe, Megan A Kaster, Regina G Szlag, Evan R Trivedi
Boron subphthalocyanines (SPcs) are aromatic macrocycles that possess a combination of physical and optical properties that make them excellent candidates for application as fluorescent imaging probes. These molecules have intense electronic absorption and emission, and structural versatility that allows for specific tuning of physical properties. Herein, we report the synthesis of a series of low-symmetry fluorinated SPcs and compare them to analogous compounds with varying numbers of peripheral fluorine atoms and varied aromaticity...
June 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28585107/a-technique-to-define-extrahepatic-biliary-anatomy-using-robotic-near-infrared-fluorescent-cholangiography
#19
Ajay V Maker, Nicholas Kunda
BACKGROUND: Bile duct injury is a rare but serious complication of minimally invasive cholecystectomy. Traditionally, intraoperative cholangiogram has been used in difficult cases to help delineate anatomical structures, however, new imaging modalities are currently available to aid in the identification of extrahepatic biliary anatomy, including near-infrared fluorescent cholangiography (NIFC) using indocyanine green (ICG).1-5 The objective of the study was to evaluate if this technique may aid in safe dissection to obtain the critical view...
June 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28584787/structure-inherent-targeting-of-near-infrared-fluorophores-for-image-guided-surgery
#20
REVIEW
Danbi Jo, Hoon Hyun
Although various clinical imaging modalities have been developed to visualize internal body structures and detect abnormal tissues prior to surgical procedures, most medical imaging modalities do not provide disease-specific images in real-time. Optical imaging can provide the surgeon with real-time visualization of the surgical field for intraoperative image-guided surgery. Imaging in the near-infrared (NIR) window (650-900 nm), also known as the "therapeutic window" has high potential by offering low absorbance and scattering in tissues resulting in minimized background autofluorescence...
May 2017: Chonnam Medical Journal
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