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Fluorescence imaging in tumor mice

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https://www.readbyqxmd.com/read/29344592/ph-responsible-fluorescent-carbon-nanoparticles-for-tumor-selective-theranostics-via-ph-turn-on-off-fluorescence-and-photothermal-effect-in-vivo-and-in-vitro
#1
Eun Bi Kang, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Insik In, Ji Hoon Jeong, Sung Young Park
We developed nanoparticles comprising a photothermal dye (IR825)-loaded carbonized zwitterionic polymer [FNP-I] as "switch-on" pH-responsive fluorescence probes to sense intracellular cancer cells and for near-infrared (NIR) controllable photothermal therapy (PTT) in vivo and in vitro. The fluorescent "off" of FNP-I was activated after reaching the cancer cell environment, where the zwitterionic compartment of FNP lost its hydrophobicity to induce PTT-mediated heat release of IR825 under NIR irradiation in the tumor...
January 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29341330/real-time-and-high-resolution-bioimaging-with-bright-aggregation-induced-emission-dots-in-short-wave-infrared-region
#2
Ji Qi, Chaowei Sun, Abudureheman Zebibula, Hequn Zhang, Ryan T K Kwok, Xinyuan Zhao, Wang Xi, Jacky W Y Lam, Jun Qian, Ben Zhong Tang
Fluorescence imaging in the spectral region beyond the conventional near-infrared biological window (700-900 nm) can theoretically afford high resolution and deep tissue penetration. Although some efforts have been devoted to developing a short-wave infrared (SWIR; 900-1700 nm) imaging modality in the past decade, long-wavelength biomedical imaging is still suboptimal owing to the unsatisfactory materials properties of SWIR fluorophores. Taking advantage of organic dots based on an aggregation-induced emission luminogen (AIEgen), herein microscopic vasculature imaging of brain and tumor is reported in living mice in the SWIR spectral region...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29338190/cancer-cell-membrane-biomimetic-nanoprobes-with-two-photon-excitation-and-near-infrared-emission-for-intravital-tumor-fluorescence-imaging
#3
Yanlin Lv, Ming Liu, Yong Zhang, Xuefei Wang, Fan Zhang, Feng Li, Weier Bao, Jie Wang, Yuanlin Zhang, Wei Wei, Guanghui Ma, Liancheng Zhao, Zhiyuan Tian
Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence (λmax ~720 nm) upon excitation of 800-nm light were developed. The key conjugated polymer enabled two-photon absorption (TPA) and Fӧrster resonance energy transfer (FRET) processes within the nanoprobes, which imparted the nanoprobes with ideal NIR-incoming-NIR-outgoing fluorescence features. The cancer cell membrane (CM) coating endowed these nanoprobes with perfect biocompatibility and highly specific targeting ability to homologous tumors...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29328618/highly-crystalline-multicolor-carbon-nanodots-for-dual-modal-imaging-guided-photothermal-therapy-of-glioma
#4
Min Qian, Yilin Du, Shanshan Wang, Chengyi Li, Huiling Jiang, Wei Shi, Jian Chen, Yi Wang, Ernst Wagner, Rongqin Huang
Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system (CNS) presents a great challenge for the current nanomaterial design. Herein, an in-situ solid-state transformation method was developed for the preparation of multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm sized HCCDs containing a highly crystalline carbon nanocore and a hydrophilic surface, which therefore simultaneously provide strong photoacoustic and photothermal performance as well as tunable fluorescence emission...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327789/imaging-macrophage-distribution-and-density-in-mammary-tumors-and-lung-metastases-using-fluorine-19-mri-cell-tracking
#5
Ashley V Makela, Paula J Foster
PURPOSE: The presence of tumor-associated macrophages (TAMs) correlates with breast cancer progression and metastatic spread. Metastasis-associated macrophages (MAMs) are also recruited to distant sites, where they support metastatic growth. In this study, we demonstrate that in vivo fluorine-19 (19 F)-based MRI cell tracking can evaluate the density and distribution of macrophages within murine breast cancer tumors and associated metastases. METHODS: Three murine breast cancer cell lines with different metastatic potentials (4T1, 168FARN, and 67NR) were implanted into the mammary fat pad in mice...
January 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29325740/indocyanine-green-loaded-hyaluronan-derived-nanoparticles-for-fluorescence-enhanced-surgical-imaging-of-pancreatic-cancer
#6
Bowen Qi, Ayrianne J Crawford, Nicholas E Wojtynek, Megan B Holmes, Joshua J Souchek, Graca Almeida-Porada, Quan P Ly, Samuel M Cohen, Michael A Hollingsworth, Aaron M Mohs
Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. In this study, hyaluronic acid derived nanoparticles with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG was not cytotoxic to healthy pancreatic epithelial cells and did not induce chemotaxis or phagocytosis, it accumulated significantly within the pancreas in an orthotopic pancreatic ductal adenocarcinoma model, and demonstrated contrast-enhancement for pancreatic lesions relative to non-diseased portions of the pancreas...
January 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29323875/theranostics-of-triple-negative-breast-cancer-based-on-conjugated-polymer-nanoparticles
#7
Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu
Triple negative breast cancer (TNBC) does not respond to many targeted drugs due to the lack of three receptors (i.e., estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2), which makes it difficult for TNBC detection and treatment. As compared to traditional breast cancer treatments such as surgery and chemotherapy, photodynamic therapy (PDT) has emerged as a promising approach for treating TNBC due to its precise controllability, high spatiotemporal accuracy and minimal invasive nature...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29313393/ultrasound-mediated-nanobubble-destruction-umnd-facilitates-the-delivery-of-a10-3-2-aptamer-targeted-and-sirna-loaded-cationic-nanobubbles-for-therapy-of-prostate-cancer
#8
Meng Wu, Hongyun Zhao, Liang Guo, Yiru Wang, Jiao Song, Xueli Zhao, Chongyan Li, Lan Hao, Dong Wang, Jie Tang
The Forkhead box M1 (FoxM1) transcription factor is an important anti-tumor target. A novel targeted ultrasound (US)-sensitive nanobubble that is likely to make use of the physical energy of US exposure for the improvement of delivery efficacy to target tumors and specifically silence FoxM1 expression appears as among the most potential nanocarriers in respect of drug delivery. In this study, we synthesized a promising anti-tumor targeted FoxM1 siRNA-loaded cationic nanobubbles (CNBs) conjugated with an A10-3...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29312629/fluorescence-guided-surgery-for-cancer-patients-a-proof-of-concept-study-on-human-xenografts-in-mice-and-spontaneous-tumors-in-pets
#9
Eliane Mery, Muriel Golzio, Stephanie Guillermet, Didier Lanore, Augustin Le Naour, Benoît Thibault, Anne Françoise Tilkin-Mariamé, Elizabeth Bellard, Jean Pierre Delord, Denis Querleu, Gwenael Ferron, Bettina Couderc
Surgery is often the first treatment option for patients with cancer. Patient survival essentially depends on the completeness of tumor resection. This is a major challenge, particularly in cases of peritoneal carcinomatosis, where tumors are widely disseminated in the large peritoneal cavity. Any development to help surgeons visualize these residual cells would improve the completeness of the surgery. For non-disseminated tumors, imaging could be used to ensure that the tumor margins and the draining lymph nodes are free of tumor deposits...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302970/tailor-making-fluorescent-hyaluronic-acid-microgels-via-combining-microfluidics-and-photoclick-chemistry-for-sustained-and-localized-delivery-of-herceptin-in-tumor
#10
Jing Chen, Ke Huang, Qijun Chen, Chao Deng, Jian Zhang, Zhiyuan Zhong
Antibody therapeutics though representing a most used biomedicine suffers from poor in vivo stability, rapid degradation, and frequent injections. Here, we report that fluorescent hyaluronic acid microgels (HMGs) tailor-made by combining microfluidics and "tetrazole-alkene" photoclick chemistry enable sustained and localized delivery of Herceptin in ovarian tumor. HMGs were obtained with defined size (25-50 μm), narrow size distribution, high stability, and strong green fluorescence. Notably, HMGs exhibited a remarkably high loading of proteins like Herceptin and IgG with a loading efficiency exceeding 90% at a theoretical protein loading content of 30 wt...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29299920/targeted-imaging-of-brain-tumors-with-a-framework-nucleic-acid-probe
#11
Tian Tian, Jiang Li, Cao Xie, Yanhong Sun, Haozhi Lei, Xinyi Liu, Jiaoyun Xia, Jiye Shi, Lihua Wang, Weiyue Lu, Chunhai Fan
Development of agents for delivering drugs and imaging probes across the blood brain barrier (BBB) remains a major challenge. In this study, we designed a biocompatible framework nucleic acid (FNA)-based imaging probe for brain tumor targeting. We employed a typical type of FNAs, tetrahedral DNA nanostructures (TDNs), as the building block, which were modified with angiopep-2 (ANG), a 19-mer peptide derived from human Kunitz domain of aprotinin. This probe exhibited high binding efficiency with low-density lipoprotein receptor-related protein-1 (LRP-1) of BBB and glioma...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29299117/a-new-bioluminescent-reporter-system-to-study-the-biodistribution-of-systematically-injected-tumor-derived-bioluminescent-extracellular-vesicles-in-mice
#12
Prakash Gangadaran, Xiu Juan Li, Ho Won Lee, Ji Min Oh, Senthilkumar Kalimuthu, Ramya Lakshmi Rajendran, Seung Hyun Son, Se Hwan Baek, Thoudam Debraj Singh, Liya Zhu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed and applied to monitoring of EVs derived from thyroid cancer (CAL-62 cells) and breast cancer (MDA-MB-231) in nude mice after intravenous administration and was compared with a dye-based labeling method for EV derived from CAL-62 cells. The EVs were successfully labeled with Rluc and visualized by BLI in mice...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298796/development-and-preclinical-validation-of-a-cysteine-knottin-peptide-targeting-integrin-%C3%AE-v%C3%AE-6-for-near-infrared-fluorescent-guided-surgery-in-pancreatic-cancer
#13
Willemieke Sfj Tummers, Richard H Kimura, Lotfi Abou-Elkacem, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg, Juergen K Willmann, Sanjiv S Gambhir
PURPOSE: Intraoperative near-infrared fluorescence (NIRF) imaging could help stratification for the proper primary treatment for patients with pancreatic ductal adenocarcinoma (PDAC), and achieve complete resection since it allows visualization of cancer in real time. Integrin αvβ6, a target specific for PDAC, is present in >90% of patients, and is able to differentiate between pancreatitis and PDAC. A clinically translatable αvβ6-targeting NIRF agent was developed, based on a previously developed cysteine knottin peptide for PET imaging, R01-MG, and validated in preclinical mouse models...
January 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29290827/local-intratracheal-delivery-of-perfluorocarbon-nanoparticles-to-lung-cancer-demonstrated-with-magnetic-resonance-multimodal-imaging
#14
Lina Wu, Xiaofei Wen, Xiance Wang, Chunan Wang, Xilin Sun, Kai Wang, Huiying Zhang, Todd Williams, Allen J Stacy, Junjie Chen, Anne H Schmieder, Gregory M Lanza, Baozhong Shen
Eighty percent of lung cancers originate as subtle premalignant changes in the airway mucosal epithelial layer of bronchi and alveoli, which evolve and penetrate deeper into the parenchyma. Liquid-ventilation, with perfluorocarbons (PFC) was first demonstrated in rodents in 1966 then subsequently applied as lipid-encapsulated PFC emulsions to improve pulmonary function in neonatal infants suffering with respiratory distress syndrome in 1996. Subsequently, PFC nanoparticles (NP) were extensively studied as intravenous (IV) vascular-constrained nanotechnologies for diagnostic imaging and targeted drug delivery applications...
2018: Theranostics
https://www.readbyqxmd.com/read/29290817/f%C3%A3-rster-resonance-energy-transfer-based-dual-modal-theranostic-nanoprobe-for-in-situ-visualization-of-cancer-photothermal-therapy
#15
Dehong Hu, Zonghai Sheng, Mingting Zhu, Xiaobing Wang, Fei Yan, Chengbo Liu, Liang Song, Ming Qian, Xin Liu, Hairong Zheng
The visualization of the treatment process in situ could facilitate to accurately monitor cancer photothermal therapy (PTT), and dramatically decrease the risk of thermal damage to normal cells and tissues, which represents a major challenge for cancer precision therapy. Herein, we prepare theranostic nanoprobes (NPs) for Förster resonance energy transfer (FRET)-based dual-modal imaging-guided cancer PTT, and clear visualization of the therapeutic process. The FRET-based theranostic NPs exhibit high FRET efficiency (88...
2018: Theranostics
https://www.readbyqxmd.com/read/29287147/intratumoral-visualization-of-oxaliplatin-within-a-liposomal-formulation-using-x-ray-fluorescence-spectrometry
#16
Hidenori Ando, Amr S Abu Lila, Masao Tanaka, Yusuke Doi, Yasuko Terada, Naoto Yagi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Micro-synchrotron radiation X-ray fluorescence spectrometry (µ-SR-XRF) is an X-ray procedure that utilizes synchrotron radiation as an excitation source. Micro-SR-XRF is a rapid, non-destructive technique that offers mapping and quantification of metals and biologically important elements in cell or tissue samples. Generally, the intratumor distribution of nanocarrier-based therapeutics is assessed by tracing the distribution of a labeled nanocarrier within tumor tissue, rather than by tracing the encapsulated drug...
December 29, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29284070/evaluation-of-fluorescence-guided-surgery-agents-in-a-murine-model-of-soft-tissue-fibrosarcoma
#17
Andrew C Prince, Andrew S McGee, Herrick Siegel, Eben L Rosenthal, Nicole K Behnke, Jason M Warram
BACKGROUND AND OBJECTIVES: Soft tissue sarcomas (STS) are mesenchymal malignancies. Treatment mainstay is surgical resection with negative margins ± adjuvant treatment. Fluorescence-guided surgical (FGS) resection can delineate intraoperative margins; FGS has improved oncologic outcomes in other malignancies. This novel strategy may minimize resection-associated morbidity while improving local tumor control. METHODS: We evaluate the tumor-targeting specificity and utility of fluorescence-imaging agents to provide disease-specific contrast...
December 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29277768/tumor-targeting-salmonella-typhimurium-a1-r-inhibits-osteosarcoma-angiogenesis-in-the-in-vivo-gelfoam%C3%A2-assay-visualized-by-color-coded-imaging
#18
Tasuku Kiyuna, Yasunori Tome, Fuminari Uehara, Takashi Murakami, Yong Zhang, Ming Zhao, Fuminori Kanaya, Robert M Hoffman
BACKGROUND: We previously developed a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In this model, nascent blood vessels selectively express GFP. We also previously showed that osteosarcoma cells promote angiogenesis in this assay. We have also previously demonstrated the tumor-targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R) can inhibit or regress all tested tumor types in mouse models...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277008/photodynamic-therapy-of-mouse-tumor-model-using-chlorin-e6-polyvinyl-alcohol-complex
#19
Alena I Gavrina, Marina V Shirmanova, Nadeshda A Aksenova, Diana V Yuzhakova, Ludmila B Snopova, Anna B Solovieva, Peter S Тimashev, Varvara V Dudenkova, Elena V Zagaynova
The use of polymeric carriers to deliver hydrophobic photosensitizers has been widely discussed as a way to improve both fluorescence diagnostic and photodynamic therapy (PDT) of cancers; however, the photophysical and pharmacokinetic parameters, as well as the PDT activity, of such modifications have, until now, only been poorly investigated. The purpose of the present study was to explore the efficacy of PDT with the formulation of the photosensitizer chlorin e6 (Ce6) in combination with polyvinyl alcohol (PVA) in comparison with Ce6 alone and with the clinical drug, Photodithazine in a mouse tumor model...
December 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29227553/fluorescence-lifetime-imaging-of-a-caspase-3-apoptosis-reporter
#20
Johanna M Buschhaus, Anne E Gibbons, Kathryn E Luker, Gary D Luker
Caspase-3 is a proteolytic enzyme that functions as a key effector in apoptotic cell death. Determining activity of caspase-3 provides critical information about cancer cell viability and response to treatment. To measure apoptosis in intact cells and living mice, a fluorescence imaging reporter that detects caspase-3 activity by Förster resonance energy transfer (FRET) was used. Changes in FRET by fluorescence lifetime imaging microscopy (FLIM) were measured. Unlike FRET measurements based on fluorescence intensity, lifetime measurements are independent of reporter concentration and scattering of light in tissue, making FLIM a robust method for imaging in 3D environments...
December 11, 2017: Current Protocols in Cell Biology
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