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https://www.readbyqxmd.com/read/28094573/advanced-gastric-adenocarcinoma-optimizing-therapy-options
#1
Dilsa Mizrak Kaya, Kazuto Harada, Yusuke Shimodaira, Fatemeh G Amlashi, Quan Lin, Jaffer A Ajani
Gastric adenocarcinoma (GAC) is the fifth most common cancer and third leading cause of cancer related mortality worldwide. When localized, cure is achievable with surgery and adjunctive therapies in some patients, however, once advanced, GAC is not a curable condition. Only two targeted agents (trastuzumab and ramucirumab) have been approved and apatinib was approved only in China. Because of the heterogeneous nature of GAC, it is not possible to assess a standard therapeutic approach. Areas Covered: In this review, we aimed to describe the optimal systemic therapy regimens for advanced GAC...
January 17, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28090502/is-noncurative-gastrectomy-always-a-beneficial-strategy-for-stage-iv-gastric-cancer
#2
Chang Min Lee, In Keun Choi, Jong-Han Kim, Da Won Park, Jun Suk Kim, Seong-Heum Park
PURPOSE: The purpose of this study is to suggest a treatment strategy for stage IV gastric cancer by investigating the behavioral difference between initially and recurrent metastatic disease. METHODS: We reviewed the medical records of the patients who underwent chemotherapy alone for metastatic gastric cancer between January 2006 and September 2013. Patients were divided into those who underwent chemotherapy for metastatic disease since initial diagnosis (IM group) and for metastatic recurrence after curative surgery (RM group)...
January 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28077786/nomogram-analysis-and-external-validation-to-predict-the-risk-of-lymph-node-metastasis-in-gastric-cancer
#3
Shi Chen, Run-Cong Nie, Li-Ying OuYang, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, YingBo Chen, Jun-Sheng Peng
AIM: To identify risk factors for lymph node metastasis using a nomogram for gastric cancer patients to predict lymph node metastasis. RESULTS: The Chi-square test and the logistic regression showed that the Boarrmann type, preoperative CA199 level, T stage and N stage by CT scan were independent risk factors. The concordance index (C-index) was 0.786 in the internal validation of the Nomogram model. In the external validation, the C-index was 0.809, and the AUC was 0...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076519/detection-value-of-free-cancer-cells-in-peritoneal-washing-in-gastric-cancer-a-systematic-review-and-meta-analysis
#4
Francisco Tustumi, Wanderley Marques Bernardo, Andre Roncon Dias, Marcus Fernando Kodama Pertille Ramos, Ivan Cecconello, Bruno Zilberstein, Ulysses Ribeiro-Júnior
Intraperitoneal free cancer cells in gastric adenocarcinoma are associated with a poor outcome. However, the true prognostic value of intraperitoneal free cancer cells is still unclear, leading to a lack of consensus in the management of gastric cancer. The aim of the present study is to perform a systematic review and meta-analysis to analyze intraperitoneal free cancer cells-positive patients with regard to tumor oncologic stage, recurrence, grade of cellular differentiation, and survival rates and to analyze the clinical significance of intraperitoneal free cancer cells with regard to prognosis...
December 1, 2016: Clinics
https://www.readbyqxmd.com/read/28072447/randomized-clinical-trial-comparing-standard-diet-with-perioperative-oral-immunonutrition-in-total-gastrectomy-for-gastric-cancer
#5
S Ida, N Hiki, H Cho, K Sakamaki, S Ito, K Fujitani, N Takiguchi, Y Kawashima, K Nishikawa, M Sasako, T Aoyama, M Honda, T Sato, S Nunobe, T Yoshikawa
BACKGROUND: Total gastrectomy for gastric cancer is associated with excessive weight loss and decreased calorie intake. Nutritional support using eicosapentaenoic acid modulates immune function and limits catabolism in patients with advanced cancer, but its impact in the perioperative period is unclear. METHODS: This was a randomized phase III clinical trial of addition of eicosapentaenoic acid-rich nutrition to a standard diet in patients having total gastrectomy for gastric cancer...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28070095/two-cases-of-unresectable-advanced-her2-positive-gastric-cancer-perforation-during-chemotherapy-with-trastuzumab
#6
Katsunori Matsueda, Tatsuya Toyokawa, Yuya Ueda, Shinya Endo, Masahiro Sakata, Isao Fujita, Jouichiro Horii, Takako Murakami
Case 1 was a 70-year-old man, and case 2 was a 65-year-old woman. Both were diagnosed with type 2 advanced HER2-positive gastric cancer. Capecitabine, cisplatin, and trastuzumab (HXP therapy) were administered to both patients. However, both patients developed peritonitis caused by gastric cancer perforation during HXP therapy on day 38 for case 1 and day 8 for case 2. Emergency omentum filling and gastric segmental resection were performed for both patients. The same chemotherapy regimen was continued after the surgery, and partial response was observed in both patients...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28069112/-immunohistochemical-assessment-of-her2-expression-in-gastric-cancer-a-clinicopathologic-study-of-93-cases
#7
Isabel Alvarado-Cabrero, Sara Gil-Hernández, Ana Ruelas-Perea, Diego Villaverde-Rodríguez, José Roberto Montes-Ochoa, Rafael Medrano-Guzmán
BACKGROUND: Gastric cancer in Mexico is ranked third in both males and females. Most patients present clinically with advanced disease and treatment options are sparse. HER2 overexpression in gastric cancer is related to poor outcome. Immunohistochemical testing for HER2 is becoming the standard of care for guiding adjuvant treatment of gastric cancer with trastuzumab. OBJECTIVES: To determine the frequency of HER2 overexpression in patients with gastric cancer in the Hospital de Oncología del Centro Médico Nacional, Siglo XXI and its association with other histopathological findings...
January 6, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28062937/protocol-for-enhanced-recovery-after-surgery-improves-short-term-outcomes-for-patients-with-gastric-cancer-a-randomized-clinical-trial
#8
Ryo Tanaka, Sang-Woong Lee, Masaru Kawai, Keitaro Tashiro, Satoshi Kawashima, Syuji Kagota, Kotaro Honda, Kazuhisa Uchiyama
BACKGROUND: The feasibility of the use of the enhanced recovery after surgery (ERAS) protocol in patients with gastric cancer remains unclear. METHODS: This study was a single-center, prospective randomized trial involving patients with gastric cancer undergoing curative gastrectomy. The primary end point was the length of postoperative hospital stay. Secondary end points were the postoperative complication rate, admission costs, weight loss, and amount of physical activity...
January 6, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28061855/clinical-outcomes-and-prognostic-factors-for-gastric-cancer-patients-with-bone-metastasis
#9
Jota Mikami, Yutaka Kimura, Yoichi Makari, Junya Fujita, Tomoya Kishimoto, Genta Sawada, Shin Nakahira, Ken Nakata, Masaki Tsujie, Hiroki Ohzato
BACKGROUND: Bone metastasis due to gastric cancer is rare, and the clinical features have not been fully evaluated. We investigated the clinical features, treatment outcomes, and prognostic factors in gastric cancer patients with bone metastasis. METHODS: We retrospectively collected data on 34 consecutive patients who were diagnosed radiologically with bone metastasis due to gastric cancer. We estimated the overall survival after the diagnosis of bone metastasis using the Kaplan-Meier product-limit method and evaluated which clinicopathological factors were associated with prognostic factors for survival using univariate and multivariate Cox proportional hazards regression models...
January 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28053815/the-rare-and-challenging-presentation-of-gastric-cancer-during-pregnancy-a-report-of-three-cases
#10
Sergio Pacheco, Enrique Norero, Claudio Canales, José Miguel Martínez, María Elisa Herrera, Carolina Muñoz, Nicolás Jarufe
Pregnancy-associated gastric cancer is extremely rare. In many cases, it is diagnosed at an advanced stage because the symptoms during pregnancy are generally overlooked. We report three cases of gastric cancer during pregnancy with various outcomes. The first case included a patient with stage IV gastric cancer who received palliative chemotherapy. This patient had a preterm birth and died 7 months after diagnosis. The second case received neoadjuvant chemotherapy during pregnancy and a total gastrectomy was performed after delivery...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28053813/could-adjuvant-chemotherapy-after-surgery-benefit-elderly-patients-with-advanced-gastric-cancer
#11
Jin Woon Jeong, In Gyu Kwon, Young-Gil Son, Seung Wan Ryu
PURPOSE: The aim of this study was to evaluate tolerance to adjuvant chemotherapy, and to compare survival between treatments using only surgery and using surgery with adjuvant chemotherapy, in elderly patients with advanced gastric cancer who were ≥75 years of age. MATERIALS AND METHODS: Patients ≥75 years of age who were diagnosed with pathological stage II or III gastric cancer were identified retrospectively and categorized into the surgery only and surgery with adjuvant chemotherapy groups...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28053812/outcome-of-gastric-cancer-surgery-in-elderly-patients
#12
Min Sung Kim, Sungsoo Kim
PURPOSE: Owing to increased life expectancy, the number of elderly patients with gastric cancer has increased. This study aimed to identify the outcomes of gastric cancer patients aged 80 years or older through comparison of their clinicopathological characteristics, surgical outcomes, and oncologic outcomes. MATERIALS AND METHODS: Between January 2006 and December 2013, the records of 478 patients who underwent surgery for gastric cancer were retrospectively evaluated...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28053811/anthropometric-study-of-the-stomach
#13
Eun-Gyeong Lee, Tae-Han Kim, Yeon-Ju Huh, Yun-Suhk Suh, Hye-Sung Ahn, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
PURPOSE: The aim of this study was to establish an anthropometric reference of the stomach for gastric cancer surgery and a modeling formula to predict stomach length. MATERIALS AND METHODS: Data were retrieved for 851 patients who underwent total gastrectomy at the Seoul National University Hospital between 2008 and 2013. Clinicopathological data and measurements from a formalin-fixed specimen were reviewed. The lengths (cm) of the greater curvature (GC) and lesser curvature (LC) were measured...
December 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28050659/ischemic-gastric-conditioning-by-preoperative-arterial-embolization-before-oncologic-esophagectomy-a-single-center-experience
#14
Julien Ghelfi, Pierre-Yves Brichon, Julien Frandon, Bastien Boussat, Ivan Bricault, Gilbert Ferretti, Sébastien Guigard, Christian Sengel
PURPOSE: Surgical esophagectomy is the gold standard treatment of early-stage esophageal cancer. The procedure is complicated with significant morbidity; the most severe complication being the anastomotic leakage. Anastomotic fistulas are reported in 5-25% of cases and are mainly due to gastric transplant ischemia. Here, we report our experience of ischemic pre-conditioning using preoperative arterial embolization (PreopAE) before esophagectomy. MATERIALS AND METHODS: The medical records of all patients who underwent oncologic esophagectomy from 2008 to 2015 were retrospectively reviewed...
January 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28045555/clinicopathologic-characteristics-of-elderly-with-gastric-cancer-and-the-risk-factors-of-postoperative-complications
#15
Yong Li, Bibo Tan, Liqiao Fan, Qun Zhao, Ming Tan, Dong Wang, Nan Jia, Qingwei Liu
PURPOSE: In China, gastric cancer (GC), which is one of the most common malignant tumors, has an increasing incidence in elderly population due to aging process. Since a considerable number of elderly patients with GC accepting surgical treatments developed postoperative complications, it is necessary to evaluate risk factors for postoperative complications. MATERIALS AND METHODS: In the present study, the clinicopathologic characteristics of 3,024 elderly patients (aged ≥65 years) with GC, who underwent surgery between 1996 and 2006, were examined and contributing factors for postoperative complications were analyzed...
January 3, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28041649/development-of-a-nomogram-for-predicting-the-risk-of-anastomotic-leakage-after-a-gastrectomy-for-gastric-cancer
#16
R-H Tu, J-X Lin, C-H Zheng, P Li, J-W Xie, J-B Wang, J Lu, Q-Y Chen, L-L Cao, M Lin, C-M Huang
AIMS: To investigate the incidence of and factors associated with anastomotic leakage (AL) following gastrectomy for gastric cancer. METHODS: We retrospectively analyzed 3632 patients who underwent a laparoscopic gastrectomy or open gastrectomy for gastric cancer. A logistic regression model was used to identify the determinant variables, and a nomogram for AL was developed. RESULTS: A total of 3632 patients were included in the study, 50 of whom (1...
December 20, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28035352/expression-of-ribophorine-ii-is-a-promising-prognostic-factor-in-human-gastric-adenocarcinoma
#17
Daisuke Fujimoto, Takanori Goi, Yasuo Hirono
The increased invasiveness of gastric adenocarcinoma is important for progression and metastasis. In recent molecular biological studies, ribophorine II (RPN2) induced epithelial-mesenchymal transition and metastatic activity. However, no studies have evaluated the relationship between RPN2 expression, ability of cancer to invade/metastasis, and patient prognosis in gastric adenocarcinoma. Therefore, we have examined these factors. Immunohistochemical staining was performed to detect RPN2 and p53 in the primary lesion and adjacent normal gastric mucosa of 242 gastric adenocarcinoma patients who underwent resection surgery...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28028665/surgery-after-intraperitoneal-and-systemic-chemotherapy-for-gastric-cancer-with-peritoneal-metastasis-or-positive-peritoneal-cytology-findings
#18
Hironori Ishigami, Hironori Yamaguchi, Hiroharu Yamashita, Masahiro Asakage, Joji Kitayama
BACKGROUND: Despite recent progress in systemic chemotherapy, the prognosis of gastric cancer patients with peritoneal metastasis (P1) or positive peritoneal cytology findings (CY1) is still poor. We developed a regimen combining intraperitoneal (IP) paclitaxel (PTX) with S-1 and PTX, which can produce notable efficacy with regard to peritoneal lesions. Surgery after response to combination chemotherapy is a promising option for P1 or CY1 gastric cancer. A retrospective study was performed to evaluate the safety and efficacy...
December 27, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/28028372/long-term-prognostic-impact-of-circulating-tumour-cells-in-gastric-cancer-patients
#19
Hiroaki Ito, Jun Sato, Yukio Tsujino, Noriko Yamaguchi, Satoshi Kimura, Keigo Gohda, Katsuhiro Murakami, Manabu Onimaru, Tohru Ohmori, Fumihiro Ishikawa, Haruhiro Inoue
AIM: To analyse the long-term prognostic impact of circulating tumour cells (CTCs) in gastric cancer patients who underwent surgery. METHODS: A 7.5-mL peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerase-specific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28028361/characterization-of-smooth-muscle-enteric-nerve-interstitial-cells-of-cajal-and-fibroblast-like-cells-in-the-gastric-musculature-of-patients-with-diabetes-mellitus
#20
Kyung Sik Park, Kwang Bum Cho, Il Seon Hwang, Jae Hyung Park, Byung Ik Jang, Kyeong Ok Kim, Sung Woo Jeon, Eun Soo Kim, Chang Sik Park, Joong Goo Kwon
AIM: To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus (DM). METHODS: Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5 (PGP9.5), neuronal nitric oxide synthase (nNOS), vasoactive intestinal peptide (VIP), neurokinin-1 (NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha, (PDGFRα)]...
December 14, 2016: World Journal of Gastroenterology: WJG
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