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https://www.readbyqxmd.com/read/28935529/combat-with-esophagojejunal-anastomotic-leakage-after-total-gastrectomy-for-gastric-cancer-a-critical-review-of-the-literature
#1
REVIEW
Wenbin Gong, Junsheng Li
Esophagojejunal anastomotic leakage (EJAL) is considered to be one of the most serious complications after total gastrectomy (TG), despite improvements in surgical instruments and technique. The occurrence of EJAL would cause poorer quality of life, prolonged hospital stay, and increased surgery-related costs and mortality. Although there is ever-increasing knowledge about EJAL, the optimal management is controversial. In the present review, we aim to demonstrate the effective management by focus on the possible risk factors, potentially useful preventive strategies, and several kinds of treatments in esophagojejunal anastomotic leakage after total gastrectomy for gastric cancer...
September 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28934828/-treatment-strategies-after-non-curative-endoscopic-resection-of-early-gastric-cancer
#2
REVIEW
Shin Hee Kim, Su Jin Hong
The cases of non-curative endoscopic resection (NCR) of early gastric cancer have increased due to the widespread use of endoscopic submucosal dissection (ESD). NCR is associated with augmenting chances of local recurrence and lymph node metastasis (LNM). Therefore, some additional treatment strategies after NCR are needed. Treatment strategies for NCR should be determined by considering the risk of residual tumor or local recurrence and LNM. Additional surgical treatment such as gastrectomy and lymph node dissection are recommended in patients who have high-risk of LNM...
September 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28932371/estimating-postoperative-survival-rate-of-gastric-cancer-patients-and-its-effective-factors-in-babol-northern-iran-2006-2011
#3
Seyed-Reza Modarres, Abdolrahim Gholizadeh-Pasha, Soheil Khatibi, Sepideh Siadati
BACKGROUND: The importance of gastric cancer, considering its progressive course and high mortality is one of the reasons we pay attention to patients' survival and the significance of this study was to estimate survival and determine the effective factors on patients with gastric cancer. METHODS: In this cross-sectional study, all patients with gastric cancer who underwent surgery in Shahid Beheshti Hospital, Babol, northern Iran during 2006-2011 were enrolled...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28929278/effect-and-mechanisms-of-diabetes-resolution-according-to-the-range-of-gastric-resection-and-the-length-of-anastomosis-in-animal-models-implication-for-gastric-cancer-surgery-in-patients-with-diabetes-mellitus
#4
Yeon-Ju Huh, Young-Gil Son, Tae-Han Kim, Ji-Ho Park, Tae-Jung Oh, Boram Choi, Jimin Min, Young Min Cho, Han-Kwang Yang, Hyuk-Joon Lee
BACKGROUND: To examine the effect and mechanism of Roux-en-Y gastric bypass (RYGB) on the improvement of diabetes according to the length of anastomosis and the gastric pouch volume in an animal model. METHODS: Glucose intolerance was induced with a high-fat diet for 3 months in Sprague-Dawley rats. The animals were subjected to conventional RYGB (cRYGB; 5% gastric pouch with 15-cm Roux limb, 40-cm biliopancreatic limb; n = 9), short-limb RYGB (sRYGB; 5%, 8, 4 cm; n = 9), fundus-sparing RYGB (fRYGB; 30%, 8, 4 cm; n = 9), or sham operation (n = 9)...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28927042/surgical-bypass-and-permanent-iodine-125-seed-implantation-vs-surgical-bypass-for-the-treatment-of-pancreatic-head-cancer
#5
Zhenjiang Zheng, Yinglong Xu, Shu Zhang, Guangchun Pu, Chi Cui
The present study aimed to investigate the efficacy and safety of Iodine-125 ((125)I) seed implantation in the treatment of locally advanced unresectable pancreatic head cancer. A prospective nonrandomized study was performed using data collected from patients between January 2009 and December 2012. A total of 34 patients underwent surgical bypass and permanent (125)I seed implantation (group A), and 32 patients underwent biliary and gastric bypass (group B). The preoperative variables, operative data, postoperative complications and follow-up information were examined...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924391/snp-rs3202538-in-3-utr-region-of-erbb3-regulated-by-mir-204-and-mir-211-promote-gastric-cancer-development-in-chinese-population
#6
Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu, Hong Shen
BACKGROUND/AIMS: ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focused on the miRNAs associated SNPs in the 3'-UTR of ErbB3 to investigate the further relationship of the SNPs with miRNAs among Chinese gastric cancer (GC) patients. METHODS: We performed case-control study including 851 GC patients and 799 cancer-free controls...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28922362/early-relapses-after-adjuvant-chemotherapy-suggests-primary-chemoresistance-in-diffuse-gastric-cancer
#7
Sharon Pattison, Catherine Mitchell, Stephen Lade, Trevor Leong, Rita A Busuttil, Alex Boussioutas
BACKGROUND: Survival from gastric cancer remains poor, particularly in Western populations. Previous pre-clinical and subgroup analyses of clinical trials have suggested differing benefits from fluoropyrimidine-based chemotherapeutics for diffuse and intestinal gastric cancer. This analysis examines patterns of relapse with and without adjuvant chemotherapy after curative resection for gastric cancer in these subtypes to explore the Lauren classification as a predictive marker of benefit for fluoropyrimidine-based adjuvant chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28920152/sentinel-node-navigation-surgery-for-early-gastric-cancer-analysis-of-factors-which-affect-direction-of-lymphatic-drainage
#8
Atsuo Shida, Norio Mitsumori, Shuichi Fujioka, Yuta Takano, Muneharu Fujisaki, Ryosuke Hashizume, Naoto Takahashi, Yoshio Ishibashi, Katsuhiko Yanaga
BACKGROUND AND PURPOSE: We started performing sentinel node navigation surgery (SNNS) for patients with early gastric cancer (EGC) using infrared ray electronic endoscopy (IREE) with indocyanine green injection from year 2000. The EGCs usually have complex lymphatic drainage, unidirectional or multidirectional lymphatic flow. In this study, we investigated and clarified factors that affect the direction of gastric lymphatic drainage. PATIENTS AND METHOD: Consecutive 60 patients with EGC who underwent SNNS by IREE from year 2006 to 2014 were enrolled to this study...
September 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28919717/the-influence-of-goal-directed-fluid-therapy-on-the-prognosis-of-elderly-patients-with-hypertension-and-gastric-cancer-surgery-retraction
#9
(no author information available yet)
[This retracts the article on p. 2113 in vol. 8.].
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28916967/combined-analysis-of-the-pre-and-postoperative-neutrophil-lymphocyte-ratio-predicts-the-outcomes-of-patients-with-gastric-cancer
#10
Kozo Miyatani, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
PURPOSE: The neutrophil-lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. METHODS: The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. RESULTS: The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage...
September 15, 2017: Surgery Today
https://www.readbyqxmd.com/read/28915702/targeted-therapies-for-gastric-cancer-failures-and-hopes-from-clinical-trials
#11
REVIEW
Maria Apicella, Simona Corso, Silvia Giordano
Gastric cancer is the third leading cause of cancer mortality worldwide. As surgery is the only curative treatment strategy and conventional chemotherapy has shown limited efficacy -with a median overall survival of 10 months- new treatments are urgently needed. Trastuzumab and Ramucirumab (targeting HER2 and VEGFR2, respectively) are the only targeted therapies approved so far. Indeed, most Phase III clinical trials evaluating molecular drugs in gastric cancer failed. This review will retrace the relevant clinical trials with molecular therapies performed in gastric cancer patients, discussing the possible reasons for their failure and indicating new perspective for a real improvement of the treatment of this disease...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915696/top2a-ggh-and-pecam1-are-associated-with-hematogenous-lymph-node-and-peritoneal-recurrence-in-stage-ii-iii-gastric-cancer-patients-enrolled-in-the-acts-gc-study
#12
Masanori Terashima, Wataru Ichikawa, Atsushi Ochiai, Koji Kitada, Issei Kurahashi, Shinichi Sakuramoto, Hitoshi Katai, Takeshi Sano, Hiroshi Imamura, Mitsuru Sasako
BACKGROUND: To identify factors related to relapse sites, we carried out an exploratory biomarker analysis of data from the Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer study, which is a randomized, controlled trial comparing postoperative adjuvant S-1 therapy with surgery alone in 1,059 patients with stage II/III gastric cancer. PATIENTS AND METHODS: Surgical specimens from 829 patients were retrospectively examined, and 63 genes involved in a variety of biological processes were analyzed by quantitative real-time PCR...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915206/laparoscopic-colorectal-surgery-in-patients-with-previous-abdominal-surgery-a-single-center-experience-and-literature-review
#13
Erdinc Kamer, Turan Acar, Fevzi Cengiz, Evren Durak, Mehmet Haciyanli
To present the outcomes of laparoscopic colorectal surgery in colorectal cancer patients with a previous history of abdominal surgery. Data of a total of 121 patients with primary colorectal cancer who underwent laparoscopic surgery were retrospectively analyzed. The patients were divided into 2 groups as those with previous abdominal surgery (PAS, n=34) and those without (non-PAS, n=87). Gastric and colonic surgeries were the most common procedures in the major PAS group, whereas gynecologic and obstetric surgeries and appendectomy were the most common procedures in the minor PAS group...
September 14, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28912921/validation-of-skeletal-muscle-volume-as-a-nutritional-assessment-in-patients-with-gastric-or-colorectal-cancer-before-radical-surgery
#14
Takayuki Endo, Chika Momoki, Minori Yamaoka, Saki Hachino, Satoshi Iwatani, Seiji Kiyota, Hiromu Tanaka, Daiki Habu
BACKGROUND: Recently, some studies have reported the importance of sarcopenia as a prognostic factor in patients with gastrointestinal cancer who have undergone surgery. We aimed to examine skeletal muscle volume for use in nutritional assessment of preoperative patients, and to compare the results with those of other conventional methods of nutritional assessment, such as biochemical or body composition values. METHODS: This was an open cohort study which examined skeletal muscle volume for use in nutritional assessment of preoperative patients...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28912919/intravenous-carnitine-administration-in-addition-to-parenteral-nutrition-with-lipid-emulsion-may-decrease-the-inflammatory-reaction-in-postoperative-surgical-patients
#15
Yu Koyama, Kazuki Moro, Masato Nakano, Kohei Miura, Masayuki Nagahashi, Shin-Ichi Kosugi, Junko Tsuchida, Mayuko Ikarashi, Masato Nakajima, Hiroshi Ichikawa, Takaaki Hanyu, Yoshifumi Shimada, Jun Sakata, Hitoshi Kameyama, Takashi Kobayashi, Toshifumi Wakai
BACKGROUND: A prospective randomized study was performed to investigate the validity of intravenous carnitine administration during postoperative parenteral nutrition (PN) with lipid emulsion. METHODS: Patients undergoing surgery for gastric or colorectal cancer were enrolled in the study and were randomly divided into two groups (n = 8 in each group): 1) group L, who received a peripheral PN (PPN) solution of 7.5% glucose, 30% amino acid, and 20% lipid emulsion; and 2) group LC, who received the same PPN solution, as well as carnitine intravenously...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28912412/-a-case-of-advanced-neuroendocrine-cell-carcinoma-of-the-stomach-treated-with-s-1-and-cisplatin-chemotherapy
#16
Mikiko Sakuraya, Yoshimasa Shimizu, Nobuo Tachikawa, Hitoshi Hara, Masaki Ohashi, Tomoo Shatari, Masao Hori
A 69-year-old man presented to our hospital because of epigastric pain. A type 2 lesion was seen in the lesser curvature of the antrum of the stomach. A moderately differentiated adenocarcinoma(human epidermal growth factor receptor 2-negative) was diagnosed by biopsy. Abdominal computed tomography showed a mass shadow 52mm in diameter in the pyloric region invading the surrounding organs, but no evidence of distant metastasis. Chemotherapy with S-1 and cisplatin(SP therapy)was initiated because of a diagnosis of locally advanced gastric cancer...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28912402/-ii-the-role-of-extended-surgery-for-advanced-gastric-cancer
#17
Kenichiro Furukawa, Noriyuki Nishiwaki, Keiichi Fujiya, Hayato Omori, Sanae Kaji, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
No abstract text is available yet for this article.
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28905005/management-of-gastric-cancer-in-indian-population
#18
REVIEW
Mohammed Ibrahim, Kissan Gilbert
Adenocarcinoma stands the most common malignancies in the gastric carcinomas and holds a significant mortality and morbidity rates annually, due to the early vague symptoms among the population and hence the delayed presentation at advanced stages of cancer. In India the screening programs for gastric cancer has been a setback due to various logistics reasons and the data available from reporting is also not content. Our study is a review article featuring the management of gastric cancer in the Indian population...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28903552/impact-of-body-mass-index-on-the-quality-of-life-after-total-gastrectomy-for-gastric-cancer
#19
Ki Bum Park, Ji Yeon Park, Seung Soo Lee, Oh Kyoung Kwon, Ho Young Chung, Wansik Yu
Purpose: We evaluated the impact of postoperative body mass index (BMI) shifts on the quality of life (QoL) following total gastrectomy in patients with gastric cancer. Methods and Methods: QoL data collected from the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-STO22 questionnaires were obtained from 417 patients preoperatively and 1 year after surgery. Patients were divided into two groups based on changes in BMI: group 1 comprised patients whose BMI range category dropped, and group 2 included patients who maintained or rose to a higher category compared to their preoperative BMI category...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28903131/association-of-o6-methylguanine-dna-methyltransferase-protein-expression-with-postoperative-prognosis-and-adjuvant-chemotherapeutic-benefits-among-patients-with-stage-ii-or-iii-gastric-cancer
#20
Yifan Cao, Hao Liu, He Li, Chao Lin, Ruochen Li, Songyang Wu, Heng Zhang, Hongyong He, Weijuan Zhang, Jiejie Xu
Importance: Loss of O6-methylguanine-DNA methyltransferase (MGMT) protein expression has been reported in several malignant tumors and predicts dismal survival outcomes. In gastric cancer, existing studies on this topic are limited and the association between MGMT and fluorouracil-based adjuvant chemotherapy remains obscure. Objective: To investigate the postoperative prognostic significance of MGMT in patients with resectable gastric cancer and its responsiveness to fluorouracil-based adjuvant chemotherapy...
September 13, 2017: JAMA Surgery
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