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https://www.readbyqxmd.com/read/28506447/effects-of-continuous-use-of-probiotics-before-liver-transplantation-a-randomized-double-blind-placebo-controlled-trial
#1
Michał Grąt, Karolina M Wronka, Zbigniew Lewandowski, Karolina Grąt, Maciej Krasnodębski, Jan Stypułkowski, Wacław Hołówko, Łukasz Masior, Irena Kosińska, Michał Wasilewicz, Joanna Raszeja-Wyszomirska, Sławomir Rejowski, Emil Bik, Waldemar Patkowski, Marek Krawczyk
BACKGROUND & AIMS: Although there is increasing evidence for the benefits of probiotics in patients with liver diseases, data on the benefits of pre-LT administration of probiotics are lacking. The aim of this study was to evaluate the effects of continuous administration of probiotics before liver transplantation (LT) on pre- and post-transplant patient outcomes. METHODS: In this randomized, double-blind, and placebo-controlled trial adult cirrhotic patients listed for LT received a 4-strain probiotic preparation or placebo daily from enrollment until LT...
May 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28490609/a-genome-wide-association-study-of-ivgtt-based-measures-of-first-phase-insulin-secretion-refines-the-underlying-physiology-of-type-2-diabetes-variants
#2
Andrew R Wood, Anna Jonsson, Anne U Jackson, Nan Wang, Nienke van Leewen, Nicholette D Palmer, Sayuko Kobes, Joris Deelen, Lorena Boquete-Vilarino, Jussi Paananen, Alena Stančáková, Dorret I Boomsma, Eco Jc de Geus, Elisabeth Mw Eekhoff, Andreas Fritsche, Mark Kramer, Giel Nijpels, Annemarie Simonis-Bik, Timon W van Haeften, Anubha Mahajan, Michael Boehnke, Richard N Bergman, Jaakko Tuomilehto, Francis S Collins, Karen L Mohlke, Karina Banasik, Christopher J Groves, Mark I McCarthy, Ewan R Pearson, Andrea Natali, Andrea Mari, Thomas A Buchanan, Kent D Taylor, Anny H Xiang, Anette P Gjesing, Niels Grarup, Hans Eiberg, Oluf Pedersen, Yii-Derr Chen, Markku Laakso, Jill M Norris, Ulf Smith, Lynne E Wagenknecht, Leslie Baier, Donald W Bowden, Torben Hansen, Mark Walker, Richard M Watanabe, Leen M 't Hart, Robert L Hanson, Timothy M Frayling
No abstract text is available yet for this article.
May 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28467461/16s-rrna-gene-sequencing-and-healthy-reference-ranges-for-28-clinically-relevant-microbial-taxa-from-the-human-gut-microbiome
#3
Daniel E Almonacid, Laurens Kraal, Francisco J Ossandon, Yelena V Budovskaya, Juan Pablo Cardenas, Elisabeth M Bik, Audrey D Goddard, Jessica Richman, Zachary S Apte
Changes in the relative abundances of many intestinal microorganisms, both those that naturally occur in the human gut microbiome and those that are considered pathogens, have been associated with a range of diseases. To more accurately diagnose health conditions, medical practitioners could benefit from a molecular, culture-independent assay for the quantification of these microorganisms in the context of a healthy reference range. Here we present the targeted sequencing of the microbial 16S rRNA gene of clinically relevant gut microorganisms as a method to provide a gut screening test that could assist in the clinical diagnosis of certain health conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28460470/a-novel-oncolytic-adenovirus-based-on-simian-adenovirus-serotype-24
#4
Tao Cheng, Yufeng Song, Yan Zhang, Chao Zhang, Jieyun Yin, Yudan Chi, Dongming Zhou
Among the oncolytic virotherapy, an emerging treatment for tumor, adenoviruses are widely used at present in preclinical and clinical trials. Traditionally, oncolytic adenoviruses were developed based on the human adenovirus serotype 5 (AdHu5). However, AdHu5 has the drawbacks of preexisting anti-AdHu5 immunity in most populations, and extensive sequestration of Adhu5 by the liver through hexon, blood coagulation factor X (FX), and FX receptor interactions. To tackle these problems, we explored a novel oncolytic adenovirus AdC7-SP/E1A-ΔE3 for cancer treatment...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28450937/whole-extracts-of-radix-achyranthis-bidentatae-and-radix-cyathulae-promote-angiogenesis-in-human-umbilical-vein-endothelial-cells-in-vitro-and-in-zebrafish-in-vivo
#5
Xuelin Zhou, Wing-Sum Siu, Cheng Zhang, Cheuk-Lun Liu, Ling Cheng, Hin-Fai Kwok, Chak-Hei Fung, Jacqueline Chor-Wing Tam, Ching-Po Lau, Clara Bik-San Lau, Ping-Chung Leung, Leung-Kim Hung, Chun-Hay Ko
Although Radix Achyranthis Bidentatae (RAB) and Radix Cyathulae (RC) are from two different medicinal plants, they are both used as 'Niu-Xi', a widely used traditional Chinese medicine that is believed to stimulate menstruation and affect bone injury. Angiogenesis is actively involved in treating these illnesses. The aim of the present study was to investigate whether the whole extracts of RAB and RC possess pro-angiogenic effects. In order to examine this idea whole extracts of RAB and RC were extracted with boiling water followed by ethanol, respectively...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28439063/liver-transplantation-outcomes-in-recipients-with-high-model-for-end-stage-liver-disease-meld-scores-the-relevance-of-meld-scores
#6
Karolina Maria Wronka, Michał Grąt, Jan Stypułkowski, Emil Bik, Maciej Krasnodębski, Łukasz Masior, Karolina Grąt, Waldemar Patkowski, Marek Krawczyk
BACKGROUND The aim of this study was to assess risk factors for postoperative mortality after liver transplantation among patients with Model for End-Stage Liver Disease (MELD) scores ≥35, with special focus on the MELD scores. MATERIAL AND METHODS Data from 68 primary liver transplantations in patients with MELD scores ≥35 among 1376 liver transplantations performed in the Department of General, Transplant, and Liver Surgery (Medical University of Warsaw) between January 2002 and October 2014 were analyzed retrospectively...
April 25, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28412412/autophagy-regulatory-molecule-tmem74-interacts-with-bik-and-inhibits-bik-induced-apoptosis
#7
Yizhe Sun, Qi Li, Jingyu Zhang, Zhongjiang Chen, Qihua He, Xi Liu, Ning Zhao, Ang Yin, He Huang, Minwei He, Lulu Cao, Lu Wang
TMEM74 (Transmembrane protein 74), a lysosome transmembrane protein, induces cell autophagy. Knockdown of TMEM74 abolished EBSS-induced autophagy. BIK, belonging to BOP (BH3-only protein) protein family, has been reported to induce cell apoptosis. Autophagy and apoptosis, as different pathways regulated by extra- or intra-cellular signals precisely, both play a crucial role in processes of intra-cellular substrates degradation, energy metabolism and cell survival. However, the relationship between autophagy and apoptosis still remains elusive...
April 13, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28412218/evaluation-of-the-combined-use-of-metronomic-zoledronic-acid-and-coriolus-versicolor-in-intratibial-breast-cancer-mouse-model
#8
Chun-Hay Ko, Grace Gar-Lee Yue, Si Gao, Ke-Wang Luo, Wing-Sum Siu, Wai-Ting Shum, Hoi-Ting Shiu, Julia Kin-Ming Lee, Gang Li, Ping-Chung Leung, Andreas Evdokiou, Clara Bik-San Lau
ETHNOPHARMACOLOGICAL RELEVANCE: Coriolus versicolor (CV) is a mushroom traditionally used for strengthening the immune system and nowadays used as immunomodulatory adjuvant in anticancer therapy. Breast cancer usually metastasizes to the skeleton, interrupts the normal bone remodeling process and causes osteolytic bone lesions. The aims of the present study were to evaluate its herb-drug interaction with metronomic zoledronate in preventing cancer propagation, metastasis and bone destruction...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28405006/the-adjuvant-value-of-andrographis-paniculata-in-metastatic-esophageal-cancer-treatment-from-preclinical-perspectives
#9
Lin Li, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Eric Chun-Wai Wong, Kwok-Pui Fung, Jun Yu, Clara Bik-San Lau, Philip Wai-Yan Chiu
Esophageal cancer (EC) is the fourth and sixth leading cause of cancer-related deaths in China and United States, respectively. The dismal prognosis of EC is mainly attributed to distant metastases, which may not be overcome by chemotherapy alone. Hence, the use of alternative adjuvant treatments, such as herbal medicines, for metastatic EC remains a great desire of patients. Our previous study demonstrated the in vivo anti-tumor and in vitro anti-invasion activities of Andrographis paniculata (AP) in esophageal cancer...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386382/protective-effects-of-an-ethanol-extract-of-angelica-keiskei-against-acetaminophen-induced-hepatotoxicity-in-hepg2-and-heparg-cells
#10
Yoon-Hee Choi, Hyun Sook Lee, Cha-Kwon Chung, Eun Ji Kim, Il-Jun Kang
BACKGROUND/OBJECTIVE: Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS: AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP...
April 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28383207/nimbolide-induces-apoptosis-in-human-nasopharyngeal-cancer-cells
#11
Su-Yu Chien, Ching-Hui Hsu, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Yi-Ting Hsi, Ming-Ju Hsieh, Mu-Kuan Chen
Nasopharyngeal carcinoma (NPC), a tumor arising from epithelial cells that cover the surface and line the nasopharynx, is a rare malignancy worldwide but is prevalent in certain geographical areas, such as Southern Asia (Taiwan, Hong Kong, Singapore, Malaysia, and Southern China) and North Africa. Despite advances in diagnostic techniques and improvements in treatment modalities, the prognosis of NPC remains poor. Therefore, an effective chemotherapy regimen that enhances tumor sensitivity to chemotherapeutics is urgently required...
April 6, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28376746/stunting-wasting-and-associated-factors-among-children-aged-6-24%C3%A2-months-in-dabat-health-and-demographic-surveillance-system-site-a-community-based-cross-sectional-study-in-ethiopia
#12
Terefe Derso, Amare Tariku, Gashaw Andargie Biks, Molla Mesele Wassie
BACKGROUND: Though there is a marked decline in burden of undernutrition, about 44 and 10% of children under five are stunted and wasted, respectively in Ethiopia. The highest prevalence of wasting occurs in young children (6-23 months), however literature are limited in these population groups. Therefore, this study aimed to assess stunting, wasting and associated factors among children aged 6-24 months in Dabat Health and Demographic Surveillance System (HDSS) site, northwest Ethiopia...
April 4, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28373418/differing-mechanisms-of-death-induction-by-fluorinated-taxane-sb-t-12854-in-breast-cancer-cells
#13
Michael Jelinek, Adela Kabelova, Jan Sramek, Joshua Seitz, Iwao Ojima, Jan Kovar
BACKGROUND/AIM: Classical taxanes are routinely used in cancer therapy. In this study, mechanisms involved in death induction by the novel fluorine-containing taxane SB-T-12854 were investigated. MATERIALS AND METHODS: We employed breast cancer SK-BR-3, MCF-7 and T47D cell lines to assess activation of individual caspases, changes in the expression of proteins of the Bcl-2 family, and the release of pro-apoptotic factors from mitochondria into the cytosol after SB-T-12854 treatment...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28368239/apoptosis-of-pancreatic-%C3%AE-cells-in-type-1-diabetes
#14
REVIEW
Tatsuo Tomita
Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells after an asymptomatic period over years. Insulitis activates antigen presenting cells, which trigger activating CD4+ helper-T cells, releasing chemokines/cytokines. Cytokines activate CD8+ cytotoxic -T cells, which lead to β-cell destruction. Apoptosis pathway consists of extrinsic (receptor-mediated) and intrinsic (mitochondria-driven) pathway. Extrinsic pathway includes Fas pathway to CD4+-CD8+ interaction, whereas intrinsic pathway includes mitochondria-driven pathway at a balance between pro-apoptotic B-cell lymphoma (Bcl) 2 and Bcl-xL and anti-apoptotic Bad, Bid, and Bik proteins...
April 3, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28359240/elaborating-the-role-of-natural-products-on-the-regulation-of-autophagy-and-their-potentials-in-breast-cancer-therapy
#15
Xunian Zhou, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Jianxin Pu, Kwok-Pui Fung, Clara Bik-San Lau
Autophagy is an intracellular lysosomal/vacuolar degradation system, which the inner cytoplasmic cell membrane is degraded by the lysosomal hydrolases, followed by the resulting products released back into the cytosol. It is involved in many physiological processes which are crucial for cell growth and survival. However, disturbance in the autophagic process is often associated with a variety of human diseases, such as cancer. Breast cancer is one of the most malignant tumors characterized by the imbalanced cell proliferation, apoptosis as well as disordered autophagy regulation...
March 30, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#16
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28300671/the-effect-of-cart-on-pituitary-hormones-release-from-cultured-pituitary-cells-harvested-from-fasted-and-fed-ad-libitum-male-rats
#17
M Chmielowska, B Baranowska, E Wolinska-Witort, L Martynska, M Kalisz, A Litwiniuk, W Bik
Cocaine and Amphetamine-Regulated Transcript (CART) is widely expressed in the central nervous system and in several endocrine organs. CART is an important factor in the regulation of energy homeostasis. The aim of the study was to assess the role of CART in physiological response of pituitary cells in a course of starvation. The pituitary cells harvested from starved and fed ad libitum male rats were cultured for 48h and treated with: 0.1nM, 1nM, 10nM or 100nM doses of CART. The medium was collected after 60min and stored at -70°C until samples were further assayed for: LH, FSH, PRL, GH, TSH and ACTH...
May 2017: Peptides
https://www.readbyqxmd.com/read/28287102/plumbagin-sensitizes-breast-cancer-cells-to-tamoxifen-induced-cell-death-through-grp78-inhibition-and-bik-upregulation
#18
Anna Kawiak, Anna Domachowska, Anna Jaworska, Ewa Lojkowska
The glucose regulated protein 78 (GRP78) is a major chaperone of the endoplasmic reticulum, and a prosurvival component of the unfolded protein response. GRP78 is upregulated in many types of cancers, including breast cancer. Research has suggested that GRP78 overexpression confers chemoresistance to anti-estrogen agents through a mechanism involving the inhibition of a pro-apoptotic BH3-only protein, Bik. In the present research the role of plumbagin, a naturally occurring naphthoquinone, in GRP78-associated cell death inhibition was examined...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28249906/nr4a3-suppresses-lymphomagenesis-through-induction-of-proapoptotic-genes
#19
Alexander J A Deutsch, Beate Rinner, Martin Pichler, Katharina Prochazka, Katrin Pansy, Marco Bischof, Karoline Fechter, Stefan Hatzl, Julia Feichtinger, Kerstin Wenzl, Marie-Therese Frisch, Verena Stiegelbauer, Andreas Prokesch, Anne Krogsdam, Heinz Sill, Gerhard G Thallinger, Hildegard T Greinix, Chenguang Wang, Christine Beham-Schmid, Peter Neumeister
Nuclear orphan receptor NR4A1 exerts an essential tumor suppressor function in aggressive lymphomas. In this study, we investigated the hypothesized contribution of the related NR4A family member NR4A3 to lymphomagenesis. In aggressive lymphoma patients, low expression of NR4A3 was associated with poor survival. Ectopic expression or pharmacological activation of NR4A3 in lymphoma cell lines led to a significantly higher proportion of apoptotic cells. In a mouse NSG xenograft model of lymphoma (stably transduced SuDHL4 cells), NR4A3 expression abrogated tumor growth, compared with vector control and uninduced cells that formed massive tumors...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28247421/dynamic-assessment-of-rbc-transfusion-dependency-improves-the-prognostic-value-of-the-revised-ipss-in-mds-patients
#20
Devendra K Hiwase, Deepak Singhal, Corinna Strupp, Rakchha Chhetri, Monika M Kutyna, L Amilia Wee, Peter B Harrison, Shriram V Nath, Nicholas Wickham, Chi-Hung Hui, James X Gray, Peter Bardy, David M Ross, Ian D Lewis, John Reynolds, L Bik To, Ulrich Germing
RBC-transfusion dependency (RBC-TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification-based prognostic scoring system (WPSS) for MDS patients. However, WPSS did not include cytopenia, whereas revised International Prognostic Scoring System (IPSS-R) did not include RBC-TD. Thus, neither of these prognostic scoring systems incorporates both cytopenia and RBC-TD. We aimed to test whether RBC-TD adds prognostic value to the IPSS-R. We analyzed MDS patients not treated with disease-modifying therapy, and enrolled in SA-MDS Registry (derivation cohort; n = 295) and Dusseldorf registry (Germany; validation cohort; n = 113) using time-dependent Cox proportional regression and serial landmark analyses...
March 1, 2017: American Journal of Hematology
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