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https://www.readbyqxmd.com/read/28439063/liver-transplantation-outcomes-in-recipients-with-high-model-for-end-stage-liver-disease-meld-scores-the-relevance-of-meld-scores
#1
Karolina Maria Wronka, Michał Grąt, Jan Stypułkowski, Emil Bik, Maciej Krasnodębski, Łukasz Masior, Karolina Grąt, Waldemar Patkowski, Marek Krawczyk
BACKGROUND The aim of this study was to assess risk factors for postoperative mortality after liver transplantation among patients with Model for End-Stage Liver Disease (MELD) scores ≥35, with special focus on the MELD scores. MATERIAL AND METHODS Data from 68 primary liver transplantations in patients with MELD scores ≥35 among 1376 liver transplantations performed in the Department of General, Transplant, and Liver Surgery (Medical University of Warsaw) between January 2002 and October 2014 were analyzed retrospectively...
April 25, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28412412/autophagy-regulatory-molecule-tmem74-interacts-with-bik-and-inhibits-bik-induced-apoptosis
#2
Yizhe Sun, Qi Li, Jingyu Zhang, Zhongjiang Chen, Qihua He, Xi Liu, Ning Zhao, Ang Yin, He Huang, Minwei He, Lulu Cao, Lu Wang
TMEM74 (Transmembrane protein 74), a lysosome transmembrane protein, induces cell autophagy. Knockdown of TMEM74 abolished EBSS-induced autophagy. BIK, belonging to BOP (BH3-only protein) protein family, has been reported to induce cell apoptosis. Autophagy and apoptosis, as different pathways regulated by extra- or intra-cellular signals precisely, both play a crucial role in processes of intra-cellular substrates degradation, energy metabolism and cell survival. However, the relationship between autophagy and apoptosis still remains elusive...
April 12, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28412218/evaluation-of-the-combined-use-of-metronomic-zoledronic-acid-and-coriolus-versicolor-in-intratibial-breast-cancer-mouse-model
#3
Chun-Hay Ko, Grace Gar-Lee Yue, Si Gao, Ke-Wang Luo, Wing-Sum Siu, Wai-Ting Shum, Hoi-Ting Shiu, Julia Kin-Ming Lee, Gang Li, Ping-Chung Leung, Andreas Evdokiou, Clara Bik-San Lau
ETHNOPHARMACOLOGICAL RELEVANCE: Coriolus versicolor (CV) is a mushroom traditionally used for strengthening the immune system and nowadays used as immunomodulatory adjuvant in anticancer therapy. Breast cancer usually metastasizes to the skeleton, interrupts the normal bone remodeling process and causes osteolytic bone lesions. The aims of the present study were to evaluate its herb-drug interaction with metronomic zoledronate in preventing cancer propagation, metastasis and bone destruction...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28405006/the-adjuvant-value-of-andrographis-paniculata-in-metastatic-esophageal-cancer-treatment-from-preclinical-perspectives
#4
Lin Li, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Eric Chun-Wai Wong, Kwok-Pui Fung, Jun Yu, Clara Bik-San Lau, Philip Wai-Yan Chiu
Esophageal cancer (EC) is the fourth and sixth leading cause of cancer-related deaths in China and United States, respectively. The dismal prognosis of EC is mainly attributed to distant metastases, which may not be overcome by chemotherapy alone. Hence, the use of alternative adjuvant treatments, such as herbal medicines, for metastatic EC remains a great desire of patients. Our previous study demonstrated the in vivo anti-tumor and in vitro anti-invasion activities of Andrographis paniculata (AP) in esophageal cancer...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386382/protective-effects-of-an-ethanol-extract-of-angelica-keiskei-against-acetaminophen-induced-hepatotoxicity-in-hepg2-and-heparg-cells
#5
Yoon-Hee Choi, Hyun Sook Lee, Cha-Kwon Chung, Eun Ji Kim, Il-Jun Kang
BACKGROUND/OBJECTIVE: Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS: AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP...
April 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28383207/nimbolide-induces-apoptosis-in-human-nasopharyngeal-cancer-cells
#6
Su-Yu Chien, Ching-Hui Hsu, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Yi-Ting Hsi, Ming-Ju Hsieh, Mu-Kuan Chen
Nasopharyngeal carcinoma (NPC), a tumor arising from epithelial cells that cover the surface and line the nasopharynx, is a rare malignancy worldwide but is prevalent in certain geographical areas, such as Southern Asia (Taiwan, Hong Kong, Singapore, Malaysia, and Southern China) and North Africa. Despite advances in diagnostic techniques and improvements in treatment modalities, the prognosis of NPC remains poor. Therefore, an effective chemotherapy regimen that enhances tumor sensitivity to chemotherapeutics is urgently required...
April 6, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28376746/stunting-wasting-and-associated-factors-among-children-aged-6-24%C3%A2-months-in-dabat-health-and-demographic-surveillance-system-site-a-community-based-cross-sectional-study-in-ethiopia
#7
Terefe Derso, Amare Tariku, Gashaw Andargie Biks, Molla Mesele Wassie
BACKGROUND: Though there is a marked decline in burden of undernutrition, about 44 and 10% of children under five are stunted and wasted, respectively in Ethiopia. The highest prevalence of wasting occurs in young children (6-23 months), however literature are limited in these population groups. Therefore, this study aimed to assess stunting, wasting and associated factors among children aged 6-24 months in Dabat Health and Demographic Surveillance System (HDSS) site, northwest Ethiopia...
April 4, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28373418/differing-mechanisms-of-death-induction-by-fluorinated-taxane-sb-t-12854-in-breast-cancer-cells
#8
Michael Jelinek, Adela Kabelova, Jan Sramek, Joshua Seitz, Iwao Ojima, Jan Kovar
BACKGROUND/AIM: Classical taxanes are routinely used in cancer therapy. In this study, mechanisms involved in death induction by the novel fluorine-containing taxane SB-T-12854 were investigated. MATERIALS AND METHODS: We employed breast cancer SK-BR-3, MCF-7 and T47D cell lines to assess activation of individual caspases, changes in the expression of proteins of the Bcl-2 family, and the release of pro-apoptotic factors from mitochondria into the cytosol after SB-T-12854 treatment...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28368239/apoptosis-of-pancreatic-%C3%AE-cells-in-type-1-diabetes
#9
REVIEW
Tatsuo Tomita
Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells after an asymptomatic period over years. Insulitis activates antigen presenting cells, which trigger activating CD4+ helper-T cells, releasing chemokines/cytokines. Cytokines activate CD8+ cytotoxic -T cells, which lead to β-cell destruction. Apoptosis pathway consists of extrinsic (receptor-mediated) and intrinsic (mitochondria-driven) pathway. Extrinsic pathway includes Fas pathway to CD4+-CD8+ interaction, whereas intrinsic pathway includes mitochondria-driven pathway at a balance between pro-apoptotic B-cell lymphoma (Bcl) 2 and Bcl-xL and anti-apoptotic Bad, Bid, and Bik proteins...
April 3, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28359240/elaborating-the-role-of-natural-products-on-the-regulation-of-autophagy-and-their-potentials-in-breast-cancer-therapy
#10
Xunian Zhou, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Jianxin Pu, Kwok-Pui Fung, Clara Bik-San Lau
Autophagy is an intracellular lysosomal/vacuolar degradation system, which the inner cytoplasmic cell membrane is degraded by the lysosomal hydrolases, followed by the resulting products released back into the cytosol. It is involved in many physiological processes which are crucial for cell growth and survival. However, disturbance in the autophagic process is often associated with a variety of human diseases, such as cancer. Breast cancer is one of the most malignant tumors characterized by the imbalanced cell proliferation, apoptosis as well as disordered autophagy regulation...
March 30, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#11
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28300671/the-effect-of-cart-on-pituitary-hormones-release-from-cultured-pituitary-cells-harvested-from-fasted-and-fed-ad-libitum-male-rats
#12
M Chmielowska, B Baranowska, E Wolinska-Witort, L Martynska, M Kalisz, A Litwiniuk, W Bik
Cocaine and Amphetamine-Regulated Transcript (CART) is widely expressed in the central nervous system and in several endocrine organs. CART is an important factor in the regulation of energy homeostasis. The aim of the study was to assess the role of CART in physiological response of pituitary cells in a course of starvation. The pituitary cells harvested from starved and fed ad libitum male rats were cultured for 48h and treated with: 0.1nM, 1nM, 10nM or 100nM doses of CART. The medium was collected after 60min and stored at -70°C until samples were further assayed for: LH, FSH, PRL, GH, TSH and ACTH...
March 11, 2017: Peptides
https://www.readbyqxmd.com/read/28287102/plumbagin-sensitizes-breast-cancer-cells-to-tamoxifen-induced-cell-death-through-grp78-inhibition-and-bik-upregulation
#13
Anna Kawiak, Anna Domachowska, Anna Jaworska, Ewa Lojkowska
The glucose regulated protein 78 (GRP78) is a major chaperone of the endoplasmic reticulum, and a prosurvival component of the unfolded protein response. GRP78 is upregulated in many types of cancers, including breast cancer. Research has suggested that GRP78 overexpression confers chemoresistance to anti-estrogen agents through a mechanism involving the inhibition of a pro-apoptotic BH3-only protein, Bik. In the present research the role of plumbagin, a naturally occurring naphthoquinone, in GRP78-associated cell death inhibition was examined...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28249906/nr4a3-suppresses-lymphomagenesis-through-induction-of-pro-apoptotic-genes
#14
Alexander Ja Deutsch, Beate Rinner, Martin Pichler, Katharina Troppan, Katrin Pansy, Marco Bischof, Karoline Fechter, Stefan Hatzl, Julia Feichtinger, Kerstin Wenzl, Marie-Therese Frisch, Verena Stiegelbauer, Andreas Prokesch, Anne Margrethe Krogsdam, Heinz Sill, Gerhard G Thallinger, Hildegard T Greinix, Chenguang Wang, Christine Beham-Schmid, Peter Neumeister
Nuclear orphan receptor NR4A1 exerts an essential tumor suppressor function in aggressive lymphomas. In this study, we investigated the hypothesized contribution of the related NR4A family member NR4A3 to lymphomagenesis. In aggressive lymphoma patients, low expression of NR4A3 was associated with poor survival. Ectopic expression or pharmacological activation of NR4A3 in lymphoma cell lines led to a significantly higher proportion of apoptotic cells. In a mouse NSG xenograft model of lymphoma (stably transduced SuDHL4 cells), NR4A3 expression abrogated tumor growth, compared to vector control and uninduced cells which formed massive tumors...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28247421/dynamic-assessment-of-rbc-transfusion-dependency-improves-the-prognostic-value-of-the-revised-ipss-in-mds-patients
#15
Devendra K Hiwase, Deepak Singhal, Corinna Strupp, Rakchha Chhetri, Monika M Kutyna, L Amilia Wee, Peter B Harrison, Shriram V Nath, Nicholas Wickham, Chi-Hung Hui, James X Gray, Peter Bardy, David M Ross, Ian D Lewis, John Reynolds, L Bik To, Ulrich Germing
RBC-transfusion dependency (RBC-TD) is an independent prognostic factor for poor overall survival (OS) in the WHO classification-based prognostic scoring system (WPSS) for MDS patients. However, WPSS did not include cytopenia, whereas revised International Prognostic Scoring System (IPSS-R) did not include RBC-TD. Thus, neither of these prognostic scoring systems incorporates both cytopenia and RBC-TD. We aimed to test whether RBC-TD adds prognostic value to the IPSS-R. We analyzed MDS patients not treated with disease-modifying therapy, and enrolled in SA-MDS Registry (derivation cohort; n=295) and Dusseldorf registry (Germany; validation cohort; n=113) using time-dependent Cox proportional regression and serial landmark analyses...
March 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28194420/andrographolide-inhibits-proliferation-and-metastasis-of-sgc7901-gastric-cancer-cells
#16
Lei Dai, Gang Wang, Wensheng Pan
To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase activity were assessed. Moreover, western blotting and real-time PCR were used to examine the protein expression levels and the mRNA expression levels, respectively. The survival ratio of cells decreased with an increasing concentration of andrographolide in a dose-dependent manner...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28191894/open-ringed-structure-of-the-cdt1-mcm2-7-complex-as-a-precursor-of-the-mcm-double-hexamer
#17
Yuanliang Zhai, Erchao Cheng, Hao Wu, Ningning Li, Philip Yuk Kwong Yung, Ning Gao, Bik-Kwoon Tye
The minichromosome maintenance complex (MCM) hexameric complex (Mcm2-7) forms the core of the eukaryotic replicative helicase. During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed loading mechanism remains unclear. Here we examine the structures of the yeast MCM hexamer and Cdt1-MCM heptamer from Saccharomyces cerevisiae. Both complexes form left-handed coil structures with a 10-15-Å gap between Mcm5 and Mcm2, and a central channel that is occluded by the C-terminal domain winged-helix motif of Mcm5...
February 13, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28181527/bigelovin-triggered-apoptosis-in-colorectal-cancer-in-vitro-and-in-vivo-via-upregulating-death-receptor-5-and-reactive-oxidative-species
#18
Mingyue Li, Li-Hua Song, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Li-Mei Zhao, Lin Li, Xunian Zhou, Stephen Kwok-Wing Tsui, Simon Siu-Man Ng, Kwok-Pui Fung, Ning-Hua Tan, Clara Bik-San Lau
Colorectal cancer (CRC) is the third most prevalent cancer and the third highest cancer-related mortality in the United States. Bigelovin, a sesquiterpene lactone isolated from Inula helianthus aquatica, has been proven to induce apoptosis and exhibit anti-inflammatory and anti-angiogenic activities. However, the effects of bigelovin on CRC and underlying mechanisms have not been explored. The present study demonstrated that bigelovin exhibited potent anti-tumor activities against CRC in vitro and in vivo. Bigelovin suppressed cell proliferation and colony formation and induced apoptosis in human colorectal cancer HT-29 and HCT 116 cells in vitro...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28153967/endotoxemia-in-peritoneal-dialysis-patients-a-pilot-study-to-examine-the-role-of-intestinal-perfusion-and-congestion
#19
Claire Grant, Laura Harrison, Caroline Hoad, Luca Marciani, Eleanor Cox, Charlotte Buchanan, Carolyn Costigan, Susan Francis, Ka-Bik Lai, Cheuk-Chun Szeto, Penny Gowland, Christopher McIntyre
Endotoxemia is common in advanced chronic kidney disease and is particularly severe in those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to a reduction in circulating splanchnic volume and increased intestinal permeability. Peritoneal dialysis (PD) patients are often volume expanded and have continuous direct immersion of bowel in fluid; these may also be important factors in endotoxin translocation and would suggest different therapeutic strategies to improve it...
January 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28151486/star-pap-a-poly-a-polymerase-functions-as-a-tumor-suppressor-in-an-orthotopic-human-breast-cancer-model
#20
C Yu, Y Gong, H Zhou, M Wang, L Kong, J Liu, T An, H Zhu, Y Li
Star-PAP is a noncanonical poly(A) polymerase and required for the expression of a select set of mRNAs. However, the pathological role of Star-PAP in cancer largely remains unknown. In this study, we observed decreased expression of Star-PAP in breast cancer cell lines and tissues. Ectopic Star-PAP expression inhibited proliferation as well as colony-forming ability of breast cancer cells. In breast cancer patients, high levels of Star-PAP correlated with an improved prognosis. Moreover, by regulating the expression of BIK (BCL2-interacting killer), Star-PAP induced apoptosis of breast cancer cells through the mitochondrial pathway...
February 2, 2017: Cell Death & Disease
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