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https://www.readbyqxmd.com/read/29244748/design-of-new-generation-usable-forms-of-topical-haemostatic-agents-containing-chitosan
#1
Dorota Zielińska, Marcin H Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona, Kinga Brzoza-Malczewska
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29209314/probiotic-strain-lactobacillus-casei-bl23-prevents-colitis-associated-colorectal-cancer
#2
Elsa Jacouton, Florian Chain, Harry Sokol, Philippe Langella, Luis G Bermúdez-Humarán
The gut microbiota plays a major role in intestinal health, and an imbalance in its composition can lead to chronic gut inflammation and a predisposition to developing colorectal cancer (CRC). Currently, the use of probiotic bacteria represents an emerging alternative to treat and prevent cancer. Moreover, consumption of these beneficial bacteria may also favorably modulate the composition of the gut microbiota, which has been described in several studies to play an important role in CRC carcinogenesis. In this context, the aim of this study was to assess the protective effect of oral treatment with Lactobacillus casei BL23, a probiotic strain well known for its anti-inflammatory and anticancer properties...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29183394/socio-demographic-factors-and-availability-of-piped-fountains-affect-food-hygiene-practice-of-food-handlers-in-bahir-dar-town-northwest-ethiopia-a-cross-sectional-study
#3
Terefe Derso, Amare Tariku, Fekadu Ambaw, Marew Alemenhew, Gashaw Andargie Biks, Ansha Nega
BACKGROUND: Morbidity and mortality rates of food borne diseases are consistently highest in African due to poor food handling and sanitation practices. Thus, the study aimed to assess food handling practice and associated factors among food handlers of Restaurants in Bahir Dar Town, northwest, Ethiopia. A cross-sectional study was conducted from December, 7/2012 to January, 2/2013 among food handlers working in 106 restaurants in Bahir Dar Town. A structured questionnaire composed of socio-demographic factors, food safety knowledge, working environmental characteristics and food hygiene practice of food handlers was employed to collect the data via interviewing and observations...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29162062/rural-households-at-risk-of-malaria-did-not-own-sufficient-insecticide-treated-nets-at-dabat-hdss-site-evidence-from-a-cross-sectional-re-census
#4
Kindie Fentahun Muchie, Kassahun Alemu, Amare Tariku, Adino Tesfahun Tsegaye, Solomon Mekonnen Abebe, Mezgebu Yitayal, Tadesse Awoke, Gashaw Andargie Biks
BACKGROUND: Malaria is the leading cause of disease burden across the world, especially in African countries. Ethiopia has designed a five year (2011-2015) plan to cover 100% of the households in malarious areas with one insecticide treated net (ITN) for every two persons, and to raise consistent ITN utilization to at least 80%. However, evidence on ownership of ITN among malarious rural households in northwest Ethiopia is quite limited. Hence, the present study aimed at assessing ownership of ITN and associated factors among rural households at risk of malaria at Dabat Health and Demographic Surveillance System site, northwest Ethiopia...
November 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29153320/novel-microbial-diversity-and-functional-potential-in-the-marine-mammal-oral-microbiome
#5
Natasha K Dudek, Christine L Sun, David Burstein, Rose S Kantor, Daniela S Aliaga Goltsman, Elisabeth M Bik, Brian C Thomas, Jillian F Banfield, David A Relman
The vast majority of bacterial diversity lies within phylum-level lineages called "candidate phyla," which lack isolated representatives and are poorly understood. These bacteria are surprisingly abundant in the oral cavity of marine mammals. We employed a genome-resolved metagenomic approach to recover and characterize genomes and functional potential from microbes in the oral gingival sulcus of two bottlenose dolphins (Tursiops truncatus). We detected organisms from 24 known bacterial phyla and one archaeal phylum...
November 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29116650/microbial-biotransformations-in-the-human-distal-gut
#6
REVIEW
Elisabeth M Bik, Juan A Ugalde, Jon Cousins, Audrey D Goddard, Jessica Richman, Zachary S Apte
The human distal gut is home to a rich and dense microbial community with representatives of all three domains of life which are intricately connected with our physiology and health. The combined genomes of these microbes, collectively called the human microbiome, vastly expand the metabolic capacities of our own genome, allowing us to break down and extract energy from dietary compounds that human enzymes cannot digest. In addition, the variable composition of these communities and their biotransformations might explain inter-individual differences in toxicities, tolerances, and efficacies for certain drugs...
November 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29073295/-early-enzyme-replacement-therapy-hope-for-patients-with-mucopolysaccharidosis-type-ii
#7
Karolina Orchel-Szastak, Katarzyna Ptak, Katarzyna Hrnciar, Bożena Pilch, Urszula Kania, Mirosław Bik-Multanowski
We present an unexpected outcome of 10 years of enzyme replacement therapy of a boy with mucopolysaccharidosis type II. Due to a positive familiar history (severe disease course in a sibling) the diagnosis was established in the first month of life. Treatment with Elaprase was introduced two months later. Since then normal physical and mental development is observed. The patient presents only relatively large head circumference (+2.1 SD) and slight decrease of joints mobility. In our opinion, early introduction of enzyme replecement therapy could attenuate the disease course...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29033852/activation-of-casein-kinase-ii-by-gallic-acid-induces-bik-bax-bak-mediated-er-ca-ros-dependent-apoptosis-of-human-oral-cancer-cells
#8
Meng-Liang Lin, Shih-Shun Chen
Induction of the generation of endoplasmic reticulum (ER) calcium (Ca(++))-mediated reactive oxygen species (ROS) by gallic acid (GA) has been implicated in the mitochondrial apoptotic death of human oral cancer (OC) cells, but the molecular mechanism by which GA causes ER Ca(++) release of OC cells to undergo cell death remains unclear. Here, we report that GA-induced phosphorylation of B-cell lymphoma 2 (BCL-2)-interacting killer (BIK) (threonine (Thr) 33/Serine (Ser) 35) and p53 (Ser 15 and Ser 392), Bcl-2-associated x protein (BAX)/BCL-2 antagonist killer 1 (BAK) oligomerization on the ER and mitochondria, rising of cytosolic Ca(+)(+) and ROS, cytochrome c (Cyt c) release from the mitochondria, Ψm loss, and apoptosis were suppressed in cells co-treated with a specific inhibitor of casein kinase II (CK II) (4,5,6,7-tetrabromobenzotriazole)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017540/only-half-of-the-mothers-practiced-early-initiation-of-breastfeeding-in-northwest-ethiopia-2015
#9
Amare Tariku, Gashaw Andargie Biks, Molla Mesele Wassie, Abebaw Gebeyehu Worku, Melaku Kindie Yenit
BACKGROUND: Early initiation of breastfeeding has been well-recognized in reducing neonatal mortality; however, it remains sub-optimal in Ethiopia. This study therefore assessed the prevalence of early initiation of breastfeeding and associated factors among mothers with children aged 6-24 months in Dabat Health and Demographic Surveillance System (HDSS) site, northwest Ethiopia, where literature on the issue is markedly scarce. METHODS: This community-based cross-sectional survey was carried out from May to June, 2015, at Dabat HDSS site, Dabat District...
October 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28986568/bik-reduces-hyperplastic-cells-by-increasing-bak-and-activating-dapk1-to-juxtapose-er-and-mitochondria
#10
Yohannes A Mebratu, Ivan Leyva-Baca, Marc G Wathelet, Neal Lacey, Hitendra S Chand, Augustine M K Choi, Yohannes Tesfaigzi
Bik reduces hyperplastic epithelial cells by releasing calcium from endoplasmic reticulum stores and causing apoptosis, but the detailed mechanisms are not known. Here we report that Bik dissociates the Bak/Bcl-2 complex to enrich for ER-associated Bak and interacts with the kinase domain of DAPk1 to form Bik-DAPk1-ERK1/2-Bak complex. Bik also disrupts the Bcl2-IP3R interaction to cause ER Ca(2+) release. The ER-associated Bak interacts with the kinase and calmodulin domains of DAPk1 to increase the contact sites of ER and mitochondria, and facilitate ER Ca(2+) uptake by mitochondria...
October 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28983977/quality-of-dutch-dermatological-guidelines-according-to-agree-ii
#11
R J Borgonjen, S F K Lubeek, C M Bik, J J E van Everdingen
The number of clinical practice guidelines is increasing, but their quality is variable.(1) However, healthcare professionals/users should be able to rely on methodologically sound guidelines that are helpful and applicable in practice. To objectively assess (methodological) guideline quality, experts developed the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument. This article is protected by copyright. All rights reserved.
October 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28983058/red-cell-alloimmunization-is-associated-with-development-of-autoantibodies-and-increased-red-cell-transfusion-requirements-in-myelodysplastic-syndrome
#12
Deepak Singhal, Monika M Kutyna, Rakchha Chhetri, Li Yan A Wee, Sophia Hague, Lakshmi Nath, Shriram V Nath, Romi Sinha, Nicholas Wickham, Ian D Lewis, David M Ross, Peter G Bardy, Luen Bik To, John Reynolds, Erica M Wood, David J Roxby, Devendra K Hiwase
Up to 90% of myelodysplastic syndrome patients require red blood cell transfusion, however comprehensive data addressing red cell alloimmunization are limited. This study evaluates the incidence and clinical impact of red cell alloimmunization in a large cohort of myelodysplastic syndrome patients registered in the statewide South Australian-MDS registry. Median age of the 817 patients was 73 years, and 66% were male. The cumulative incidence of alloimmunization was 11%. Disease-modifying therapy was associated with a lower risk of alloimmunization...
October 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28971907/self-reverting-mutations-partially-correct-the-blood-phenotype-in-a-diamond-blackfan-anemia-patient
#13
Parvathy Venugopal, Sarah Moore, David M Lawrence, Amee J George, Ross D Hannan, Sarah Ce Bray, Luen Bik To, Richard J D'Andrea, Jinghua Feng, Amanda Tirimacco, Alexandra L Yeoman, Chun Chun Young, Miriam Fine, Andreas W Schreiber, Christopher N Hahn, Christopher Barnett, Ben Saxon, Hamish S Scott
No abstract text is available yet for this article.
September 29, 2017: Haematologica
https://www.readbyqxmd.com/read/28959140/curcumin-reduces-mitomycin-c-resistance-in-breast-cancer-stem-cells-by-regulating-bcl-2-family-mediated-apoptosis
#14
Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Shi-Bing Su
BACKGROUND: Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemotherapy drugs through regulation of Bcl-2-mediated apoptosis in breast cancer stem-like cells (BCSCs). METHODS: Cell survival was measured using MTT assay. Apoptosis-related proteins were observed using western blot analysis. Apoptosis was detected with flow cytometric analysis and by Hoechst 33258 staining...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28940169/the-use-of-d2-and-benton-tests-for-assessment-of-attention-deficits-and-visual-memory-in-teenagers-with-phenylketonuria
#15
Bozena Didycz, Magdalena Nitecka, Miroslaw Bik-Multanowski
Hyperphenylalaninemia-related, subtle deficits of attention and of working memory are often reported in adolescents with phenylketonuria. Focused neuropsychological tests can be used to detect such deficits and to confirm the presence of poor metabolic control in the periods between routine blood phenylalanine tests, which are rarely performed in many patients from this age group due to their low treatment adherence.We assessed the practical value of the d2 test of attention and of the Benton visual retention test for identification of teenagers, who have a high risk of brain dysfunction due to hyperphenylalaninemia...
September 24, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28936587/metabolite-ratios-as-potential-biomarkers-for-type-2-diabetes-a-direct-study
#16
Sophie Molnos, Simone Wahl, Mark Haid, E Marelise W Eekhoff, René Pool, Anna Floegel, Joris Deelen, Daniela Much, Cornelia Prehn, Michaela Breier, Harmen H Draisma, Nienke van Leeuwen, Annemarie M C Simonis-Bik, Anna Jonsson, Gonneke Willemsen, Wolfgang Bernigau, Rui Wang-Sattler, Karsten Suhre, Annette Peters, Barbara Thorand, Christian Herder, Wolfgang Rathmann, Michael Roden, Christian Gieger, Mark H H Kramer, Diana van Heemst, Helle K Pedersen, Valborg Gudmundsdottir, Matthias B Schulze, Tobias Pischon, Eco J C de Geus, Heiner Boeing, Dorret I Boomsma, Anette G Ziegler, P Eline Slagboom, Sandra Hummel, Marian Beekman, Harald Grallert, Søren Brunak, Mark I McCarthy, Ramneek Gupta, Ewan R Pearson, Jerzy Adamski, Leen M 't Hart
AIMS/HYPOTHESIS: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes...
September 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28930370/comparison-of-whole-genome-expression-profile-between-preterm-and-full-term-newborns
#17
Przemko Kwinta, Renata Bokiniec, Mirosław Bik-Multanowski, Clara-Cecilie Gunther, Agnieszka Grabowska, Teofila Książek, Anna Madetko-Talowska, Katarzyna Szewczyk, Monika Szwarc-Duma, Maria K Borszewska-Kornacka, Lars O Baumbusch, Cecilie Revhaug, Ola D Saugstad, Jacek J Pietrzyk
OBJECTIVES: Evaluate the time dependent expression of genes in preterm neonates and verify the influence of ontogenic maturation and the environmental factors on the gene expression after birth. MATERIAL AND METHODS: The study was carried out on 20 full-term newborns and 62 preterm newborns (mean birth weight = 1002 [g] (SD: 247), mean gestational age = 27.2 weeks (SD: 1.9)). Blood samples were drawn from all the study participants at birth and at the 36th week postmenstrual age from the preterm group to assess whole genome expression in umbilical cord blood and in peripheral blood leukocytes, respectively...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28926234/using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-based-chemometrics-for-the-identification-of-anti-angiogenic-biflavonoids-from-edible-garcinia-species
#18
Ping Li, Grace Gar-Lee Yue, Hin-Fai Kwok, Chun-Lin Long, Clara Bik-San Lau, Edward J Kennelly
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28921802/environmental-dna-metabarcoding-transforming-how-we-survey-animal-and-plant-communities
#19
Kristy Deiner, Holly M Bik, Elvira Mächler, Mathew Seymour, Anaïs Lacoursière-Roussel, Florian Altermatt, Simon Creer, Iliana Bista, David M Lodge, Natasha de Vere, Michael E Pfrender, Louis Bernatchez
The genomic revolution has fundamentally changed how we survey biodiversity on earth. High-throughput sequencing ("HTS") platforms now enable the rapid sequencing of DNA from diverse kinds of environmental samples (termed "environmental DNA" or "eDNA"). Coupling HTS with our ability to associate sequences from eDNA with a taxonomic name is called "eDNA metabarcoding" and offers a powerful molecular tool capable of noninvasively surveying species richness from many ecosystems. Here, we review the use of eDNA metabarcoding for surveying animal and plant richness, and the challenges in using eDNA approaches to estimate relative abundance...
September 16, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28878027/death-by-hdac%C3%A2-inhibition-in-synovial-sarcoma-cells
#20
Aimée N Laporte, Neal M Poulin, Jared J Barrott, Xiu Qing Wang, Alireza Lorzadeh, Ryan Vander Werff, Kevin B Jones, T Michael Underhill, Torsten O Nielsen
Conventional cytotoxic therapies for synovial sarcoma provide limited benefit, and no drugs specifically targeting the causative SS18-SSX fusion oncoprotein are currently available. Histone deacetylase (HDAC) inhibition has been shown in previous studies to disrupt the synovial sarcoma oncoprotein complex, resulting in apoptosis. To understand the molecular effects of HDAC inhibition, RNA-Seq transcriptome analysis was undertaken in six human synovial sarcoma cell lines. HDAC inhibition induced pathways of cell cycle arrest, neuronal differentiation and response to oxygen-containing species, effects also observed in other cancers treated with this class of drugs...
September 6, 2017: Molecular Cancer Therapeutics
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