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https://www.readbyqxmd.com/read/28820884/let-s-rise-up-to-unite-taxonomy-and-technology
#1
Holly M Bik
What do you think of when you think of taxonomy? An 18th century gentlemen in breeches? Or perhaps botany drawings hung on the walls of a boutique hotel? Such old-fashioned conceptions to the contrary, taxonomy is alive today although constantly struggling for survival and recognition. The scientific community is losing valuable resources as taxonomy experts age and retire, and funding for morphological studies and species descriptions remains stagnant. At the same time, organismal knowledge (morphology, ecology, physiology) has never been more important: genomic studies are becoming more taxon focused, the scientific community is recognizing the limitations of traditional "model" organisms, and taxonomic expertise is desperately needed to fight against global biodiversity declines resulting from human impacts...
August 2017: PLoS Biology
https://www.readbyqxmd.com/read/28810458/cognitive-and-behavioral-coping-in-people-with-chronic-fatigue-syndrome-an-exploratory-study-searching-for-intervention-targets-for-depressive-symptoms
#2
Vivian Kraaij, Janneke Bik, Nadia Garnefski
The aim of the study was to find relevant coping factors for the development of psychological interventions for people with chronic fatigue syndrome who suffer from depressive symptoms. A total of 30 adults with chronic fatigue syndrome filled in the Cognitive Emotion Regulation Questionnaire, the COPE and the Hospital Anxiety and Depression Scale. The findings suggested that cognitive coping strategies have a stronger influence than behavioral coping strategies on depressive symptoms. Especially, the cognitive coping strategies refocusing positive, positive reappraisal and catastrophizing were of importance...
May 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28796811/biphasic-ros-production-p53-and-bik-dictate-the-mode-of-cell-death-in-response-to-dna-damage-in-colon-cancer-cells
#3
Ozgur Kutuk, Nurgul Aytan, Bahriye Karakas, Asli Giray Kurt, Ufuk Acikbas, Sehime Gulsun Temel, Huveyda Basaga
Necrosis, apoptosis and autophagic cell death are the main cell death pathways in multicellular organisms, all with distinct and overlapping cellular and biochemical features. DNA damage may trigger different types of cell death in cancer cells but the molecular events governing the mode of cell death remain elusive. Here we showed that increased BH3-only protein BIK levels promoted cisplatin- and UV-induced mitochondrial apoptosis and biphasic ROS production in HCT-116 wild-type cells. Nonetheless, early single peak of ROS formation along with lysosomal membrane permeabilization and cathepsin activation regulated cisplatin- and UV-induced necrosis in p53-null HCT-116 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28781067/spatial-and-temporal-variation-of-intertidal-nematodes-in-the-northern-gulf-of-mexico-after-the-deepwater-horizon-oil-spill
#4
Pamela M Brannock, Jyotsna Sharma, Holly M Bik, W Kelley Thomas, Kenneth M Halanych
Nematodes are an abundant and diverse interstitial component of sedimentary habitats that have been reported to serve as important bioindicators. Though the 2010 Deepwater Horizon (DWH) disaster occurred 60 km offshore in the Gulf of Mexico (GOM) at a depth of 1525 m, oil rose to the surface and washed ashore, subjecting large segments of coastline in the northern GOM to contamination. Previous metabarcoding work shows intertidal nematode communities were negatively affected by the oil spill. Here we examine the subsequent recovery of nematode community structure at five sites along the Alabama coast over a two-year period...
July 6, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28769046/kaiso-protects-human-umbilical-vein-endothelial-cells-against-apoptosis-by-differentially-regulating-the-expression-of-b-cell-cll-lymphoma-2-family-members
#5
Xiaodong Xue, Jian Zhang, Huai Lan, Yinli Xu, Huishan Wang
Endothelial cell injury can promote the development of various cardiovascular diseases, thus, fully understanding the mechanisms underlying the maintenance of vascular endothelial cell homoeostasis may help prevent and treat cardiovascular disease. Kaiso, a zinc finger and BTB domain containing transcription factor, is key to embryonic development and cancer, but how Kaiso interacts with vascular endothelium is not fully understood. We report that Kaiso has an anti-apoptotic function in human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMEC-1s)...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732205/unique-roles-of-the-non-identical-mcm-subunits-in-dna-replication-licensing
#6
REVIEW
Yuanliang Zhai, Ningning Li, Hanlun Jiang, Xuhui Huang, Ning Gao, Bik Kwoon Tye
A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1...
July 20, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28722624/knowledge-attitude-and-practice-of-mothers-caregivers-on-household-water-treatment-methods-in-northwest-ethiopia-a-community-based-cross-sectional-study
#7
Bikes Destaw Bitew, Yigzaw Kebede Gete, Gashaw Andargie Biks, Takele Tadesse Adafrie
In Ethiopia, ensuring safe drinking water remains a big challenge where waterborne diseases, including diarrhea cause a great harm in many rural communities. Limited knowledge, misinformation, negative attitude, and lack of experience toward best practices of alternative water treatment technologies were among the leading challenges. A community-based cross-sectional study was conducted from June 23 to 30, 2015, in Dabat District. The study participants were selected by using simple random sampling method. Questionnaire-based face-to-face interview technique of data collection was used by 20 data collectors under close supervision with six supervisors...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721128/insulin-and-brain-aging
#8
REVIEW
Agnieszka Baranowska-Bik, Wojciech Bik
The world's population is living much longer than in the past. It is crucial to find as many pathological factors that deteriorate the health condition and well-being of elderly people as possible. Loss of activity and functions over time is typical for elderly people. Aging affects brain function, metabolism and structure in different ways, and these effects have multiple etiologies. Cognitive impairment, impaired neurotransmitter activity and reduction of brain volume are observed in the elderly population...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28720543/bik-is-involved-in-braf-mek-inhibitor-induced-apoptosis-in-melanoma-cell-lines
#9
Andreas Borst, Sebastian Haferkamp, Johannes Grimm, Manuel Rösch, Guannan Zhu, Sen Guo, Chunying Li, Tianwen Gao, Svenja Meierjohann, David Schrama, Roland Houben
In patients with BRAF-mutated melanoma specific inhibitors of BRAF(V600E) and MEK1/2 frequently induce initial tumor reduction, frequently followed by relapse. As demonstrated previously, BRAF(V600E)-inhibition induces apoptosis only in a fraction of treated cells, while the remaining arrest and survive providing a source or a niche for relapse. To identify factors contributing to the differential initial response towards BRAF/MEK inhibition, we established M14 melanoma cell line-derived single cell clones responding to treatment with BRAF inhibitor vemurafenib and MEK inhibitor trametinib predominantly with either cell cycle arrest (CCA-cells) or apoptosis (A-cells)...
July 15, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28717146/concise-and-stereodivergent-synthesis-of-carbasugars-reveals-unexpected-structure-activity-relationship-sar-of-sglt2-inhibition
#10
Wai-Lung Ng, Ho-Chuen Li, Kit-Man Lau, Anthony K N Chan, Clara Bik-San Lau, Tony K M Shing
Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to the lengthy synthetic routes and the lack of structure-activity relationship (SAR) studies of these compounds. Herein, we report a concise and stereodivergent synthetic route towards some novel carbasugar SGLT2 inhibitors, featuring an underexploited, regioselective, and stereospecific palladium-catalyzed allyl-aryl coupling reaction...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695391/challenging-the-principle-of-utility-as-a-barrier-for-wider-use-of-liver-transplantation-for-hepatocellular-cancer
#11
Michał Grąt, Jan Stypułkowski, Waldemar Patkowski, Karolina M Wronka, Emil Bik, Maciej Krasnodębski, Łukasz Masior, Zbigniew Lewandowski, Michał Wasilewicz, Karolina Grąt, Marek Krawczyk, Krzysztof Zieniewicz
BACKGROUND: Although transplant benefit appears superior for patients with advanced hepatocellular cancer (HCC), liver transplantation remains limited to selected low-risk HCC patients to keep their outcomes similar to heterogeneous group of non-HCC patients. The purpose of this study was to assess the rationale for current policy of restricting access to liver transplantation to minority of HCC patients based on utility principle. METHODS: This retrospective cohort study comprised 1246 liver transplant recipients, including 206 HCC and 1040 non-HCC patients...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28687525/smd-kozlowski-type-caused-by-p-arg594his-substitution-in-trpv4-reveals-abnormal-ossification-and-notochordal-remnants-in-discs-and-vertebrae
#12
Tadeusz Bieganski, Peter Beighton, Maciej Lukaszewski, Krzysztof Bik, Lukasz Kuszel, Ewa Wasilewska, Kazimierz Kozlowski, Malwina Czarny-Ratajczak
Spondylometaphyseal dysplasia Kozlowski type (SMDK) is a monogenic disorder within the TRPV4 dysplasia spectrum and has characteristic spinal and metaphyseal changes. We report skeletal MR imaging in a two-year-old patient who manifested typical clinical and radiographic features of SMDK. The diagnosis was confirmed by molecular analysis which revealed a mutation NM_021625.4:c.1781G > A - p.(Arg594His) in exon 11 of the TRPV4 gene. We have documented abnormalities in endochondral formation of the long and short tubular bones as well as round bones of the wrists and feet...
July 4, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28684298/polysaccharides-of-dendrobium-officinale-kimura-migo-protect-gastric-mucosal-cell-against-oxidative-damage-induced-apoptosis-in-vitro-and-in-vivo
#13
Qiang Zeng, Chun-Hay Ko, Wing-Sum Siu, Long-Fei Li, Xiao-Qiang Han, Liu Yang, Clara Bik-San Lau, Jiang-Miao Hu, Ping-Chung Leung
ETHNOPHARMACOLOGICAL RELEVANCE: Dendrobium officinale Kimura & Migo (DO) is a valuable Traditional Chinese Medicine to nourish stomach, in which polysaccharides are identified as active ingredients. However, limited scientific evidences have been reported on the gastroprotective efficacy of DO. The aim of the current study was to investigate the protective effects and underlying mechanism of polysaccharides from DO(DOP) on gastric mucosal injury. MATERIAL AND METHODS: For in vitro study, HFE145 cells were pretreated with DOP before induction of cell apoptosis by H2O2...
July 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28669564/eriocalyxin-b-a-novel-autophagy-inducer-exerts-anti-tumor-activity-through-the-suppression-of-akt-mtor-p70s6k-signaling-pathway-in-breast-cancer
#14
Xunian Zhou, Grace Gar-Lee Yue, Andrew Man-Lok Chan, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Handong Sun, Jianxin Pu, Clara Bik-San Lau
Eriocalyxin B (EriB), a natural ent-kaurane diterpenoid presented in the plant Isodon eriocalyx var. laxiflora, has been reported to diminish angiogenesis-dependent breast tumor growth. In the present study, the effects of EriBon human breast cancer and its underlying mechanisms were further investigated. The in vitro anti-breast cancer activity of EriB was determined using MCF-7 and MDA-MB-231 cell lines. MDA-MB-231 xenograft model of human breast cancer was also established to explore the anti-tumor effect in vivo...
June 29, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28658257/mothers-education-and-anc-visit-improved-exclusive-breastfeeding-in-dabat-health-and-demographic-surveillance-system-site-northwest-ethiopia
#15
Amare Tariku, Kassahun Alemu, Zemichael Gizaw, Kindie Fentahun Muchie, Terefe Derso, Solomon Mekonnen Abebe, Mezgebu Yitayal, Abel Fekadu, Tadesse Awoke Ayele, Geta Asrade Alemayehu, Adino Tesfahun Tsegaye, Alemayehu Shimeka, Gashaw Andargie Biks
INTRODUCTION: Despite its proven benefit in reducing child mortality and morbidity, the coverage of exclusive breastfeeding (EBF) remains sub-optimal. In Ethiopia, about 52% of infants under six months of age were exclusively breastfed, implying the need for further identification of the barriers to optimal EBF practice. Therefore, this study aimed to investigate EBF and its determinants in the predominantly rural northwest Ethiopia. METHODS: The study was conducted at the Dabat Health and Demographic Surveillance System (HDSS) site, which is located in Dabat District, northwest Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28652789/community-based-health-insurance-and-communities-scheme-requirement-compliance-in-thehuldere-district-northeast-ethiopia-cross-sectional-community-based-study
#16
Samuel Getachew Workneh, Gashaw Andargie Biks, Solomon Assefa Woreta
BACKGROUND: Community-based health insurance (CBHI) is becoming a prominent and promising concept in tackling financial health care issues confronting the poor rural communities in developing countries. Ethiopia endorsed and constituted CBHI schemes in 13 pilot "woredas" in 2010/11. This study aimed to assess the compliance of the community to CBHI scheme requirements in Thehuledere district, northeast Ethiopia. METHODS: A community-based cross-sectional study was conducted among 530 respondents between April and June 2015 in Thehuledere District, South Wollo Zone, northeast Ethiopia...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28638435/exclusive-breastfeeding-and-mothers-employment-status-in-gondar-town-northwest-ethiopia-a-comparative-cross-sectional-study
#17
Dawit Alemayehu Chekol, Gashaw Andargie Biks, Yalemzewod Assefa Gelaw, Yayehirad Alemu Melsew
BACKGROUND: Exclusive breastfeeding is defined as feeding an infant breast milk only, for the first six months. In Ethiopia, more than half of infants do not receive exclusive breastfeeding. Workplace barriers contribute to these low rates of exclusive breastfeeding practices. Understanding the sociodemographic, health related, behavioral and economic factors is crucial to promote the practice of exclusive breastfeeding in Ethiopia. Therefore, the aim of this study was to assess the extent of exclusive breastfeeding practice and associated factors among employed and unemployed mothers with children of age 7-12 months in Gondar town, northwest Ethiopia, 2015...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/28622297/p53-mediated-suppression-of-bip-triggers-bik-induced-apoptosis-during-prolonged-endoplasmic-reticulum-stress
#18
Ignacio López, Anne-Sophie Tournillon, Rodrigo Prado Martins, Konstantinos Karakostis, Laurence Malbert-Colas, Karin Nylander, Robin Fåhraeus
Physiological and pathological conditions that affect the folding capacity of the endoplasmic reticulum (ER) provoke ER stress and trigger the unfolded protein response (UPR). The UPR aims to either restore the balance between newly synthesized and misfolded proteins or if the damage is severe, to trigger cell death. However, the molecular events underlying the switch between repair and cell death are not well understood. The ER-resident chaperone BiP governs the UPR by sensing misfolded proteins and thereby releasing and activating the three mediators of the UPR: PERK, IRE1 and ATF6...
June 16, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28604943/adipokine-profile-in-patients-with-anorexia-nervosa
#19
Agnieszka Baranowska-Bik, Bogusława Baranowska, Lidia Martyńska, Anna Litwiniuk, Małgorzata Kalisz, Jan Kochanowski, Wojciech Bik
INTRODUCTION: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissue-derived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. MATERIAL AND METHODS: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls...
June 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28602396/mycoplasma-fermentans-deacetylase-promotes-mammalian-cell-stress-tolerance
#20
Qingzhou Cheng, Lijuan Wu, Rongfu Tu, Jun Wu, Wenqian Kang, Tong Su, Runlei Du, Wenbin Liu
Mycoplasma fermentans is a pathogenic bacterium that infects humans and has potential pathogenic roles in respiratory, genital and rheumatoid diseases. NAD(+)-dependent deacetylase is involved in a wide range of pathophysiological processes and our studies have demonstrated that expression of mycoplasmal deacetylase in mammalian cells inhibits proliferation but promotes anti-starvation stress tolerance. Furthermore, mycoplasmal deacetylase is involved in cellular anti-oxidation, which correlates with changes in the proapoptotic proteins BIK, p21 and BIM...
August 2017: Microbiological Research
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