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https://www.readbyqxmd.com/read/29454618/natural-small-molecule-bigelovin-suppresses-orthotopic-colorectal-tumor-growth-and-inhibits-colorectal-cancer-metastasis-via-il6-stat3-pathway
#1
Mingyue Li, Grace Gar-Lee Yue, Li-Hua Song, Mao-Bo Huang, Julia Kin-Ming Lee, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Ning-Hua Tan, Clara Bik-San Lau
Bigelovin, a sesquiterpene lactone, has been demonstrated to induce apoptosis, inhibit inflammation and angiogenesis in vitro, but its potential anti-metastatic activity remains unclear. In the present study, two colon cancer mouse models, orthotopic tumor allografts and experimental metastatic models were utilized to investigate the progression and metastatic spread of colorectal cancer after bigelovin treatments. Results showed that bigelovin (intravenous injection; 0.3-3 mg/kg) significantly suppressed tumor growth and inhibited liver/lung metastasis with modulation of tumor microenvironment (e...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29426265/molecular-karyotyping-in-early-miscarriages-potential-for-the-routine-use-of-cytogenetic-microarrays
#2
Katarzyna Szewczyk, Miroslaw Bik-Multanowski
No abstract text is available yet for this article.
February 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29425850/neuroprotective-effect-of-da-chuanxiong-formula-against-cognitive-and-motor-deficits-in-a-rat-controlled-cortical-impact-model-of-traumatic-brain-injury
#3
Zhi-Ke Liu, Chun-Fai Ng, Hoi-Ting Shiu, Hing-Lok Wong, Wai-Ching Chin, Jin-Fang Zhang, Ping-Kuen Lam, Wai-Sang Poon, Clara Bik-San Lau, Ping-Chung Leung, Chun-Hay Ko
ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCXF) is one of the famous herb pairs that contains dried rhizomes of Ligusticum chuanxiong Hort. and Gastrodia elata Bl. in the mass ratio of 4:1. This classic representative traditional Chinese medicine has been widely used to treat brain diseases like headache and migraine caused by blood stasis and wind pathogen. However, the therapeutic effect of DCXF on traumatic brain injury (TBI) has not been reported yet. AIM OF STUDY: The present study was performed to investigate the neuroprotective effects of DCXF and its underlying mechanisms in the controlled cortical impact (CCI)-induced TBI rat model...
February 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29372685/dna-methylation-as-mechanism-of-apoptotic-resistance-development-in-endometrial-cancer-patients
#4
Veronika Fialkova, Eva Vidomanova, Tomas Balharek, Juraj Marcinek, Erik Kudela, Sandra Hanysova, Jozef Visnovsky, Dusan Dobrota, Jozef Hatok
DNA methylation is a significant epigenetic modification which plays a key role in regulation of gene expression and influences functional changes in endometrial tissue. Aberrant DNA methylation changes result in deregulation of important apoptotic proteins during endometrial carcinogenesis and apoptosis resistance development. Evading apoptosis is still a major problem in the successful treatment of endometrial cancer patients. The aim of our study was to examine the promoter DNA methylation changes in 22 apoptosis-associated genes in endometrioid endometrial cancer patients, precancerous lesions and healthy tissue from various normal menstrual cycle phases using a unique pre-designed methylation platform...
December 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29363243/a-cohort-study-assessing-the-impact-of-small-volume-blood-tubes-on-diagnostic-test-quality-and-iatrogenic-blood-loss-in-a-cohort-of-adult-haematology-patients
#5
Nicholas Myles, Jacoba von Wielligh, Mario Kyriacou, Terry Ventrice, Luen Bik To
OBJECTIVES: to estimate the reduction in blood volume loss and diagnostic test quality associated with introduction of small volume blood tubes in a cohort of haematology inpatients compared to a historical comparator group. DESIGN: prospective cohort study. SETTING: haematology unit of a tertiary referral hospital in Adelaide. PARTICIPANTS: haematology inpatients. INTERVENTION: small volume blood tubes were used in an intervention cohort admitted between 2012-2013 and compared to a control cohort admitted between 2009-2010 where standard volume tubes had been used...
January 24, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29344113/downregulated-mirna-1269a-variant-rs73239138-decreases-the-susceptibility-to-gastric-cancer-via-targeting-znf70
#6
Wenshuai Li, Huilu Zhang, Pei Min, Jie Zhu, Diannan Xu, Weiru Jiang, Yanyun Ma, Jigang Qiu, Weihong Xu, Jian Chen, Mingqing Zhang, Min Li, Dongqin Yang, Jianping Shi, Jun Zhang, Jie Liu
Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR-1269a rs73239138 has a role in decreasing the risk of gastric cancer. The level of miR-1269a variant expression was significantly downregulated compared with the wild-type miR-1269a in the gastric cells (Fig. 1). Furthermore, overexpression of miR-1269a inhibited apoptosis of gastric cancer cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29326880/blood-phenylalanine-instability-strongly-correlates-with-anxiety-in-phenylketonuria
#7
Bozena Didycz, Miroslaw Bik-Multanowski
We assessed the relationship between anxiety and long-term metabolic control in adolescents with phenylketonuria (PKU). We used a standardized psychological test to measure anxiety level and analyzed lifelong blood phenylalanine stability in a selected group of 25 PKU teenagers with treatment adherence problems. We demonstrated significant correlations of anxiety with variability of blood phenylalanine concentrations and with severity of hyperphenylalaninemia. Avoiding blood phenylalanine fluctuations in childhood can probably reduce anxiety in PKU adolescents...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29323189/il-13-in-lps-induced-inflammation-causes-bcl-2-expression-to-sustain-hyperplastic-mucous-cells
#8
Hitendra S Chand, Jennifer F Harris, Yohannes Tesfaigzi
Exposure to lipopolysaccharides (LPS) causes extensive neutrophilic inflammation in the airways followed by mucous cell hyperplasia (MCH) that is sustained by the anti-apoptotic protein, Bcl-2. To identify inflammatory factor(s) that are responsible for Bcl-2 expression, we established an organ culture system consisting of airway epithelial tissue from the rat nasal midseptum. The highest Muc5AC and Bcl-2 expression was observed when organ cultures were treated with brochoalveolar lavage (BAL) fluid harvested from rats 10 h post LPS instillation...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29258578/stunting-and-its-determinant-factors-among-children-aged-6-59%C3%A2-months-in-ethiopia
#9
Amare Tariku, Gashaw Andargie Biks, Terefe Derso, Molla Mesele Wassie, Solomon Mekonnen Abebe
BACKGROUND: Though Ethiopia has implemented different nutritional interventions, childhood stunting on which literature is limited continues as a severe public health problem. Thus, this study aimed to investigate stunting and its determinants among children aged 6-59 months in the predominantly rural northwest Ethiopia. METHODS: A community based cross-sectional study was conducted from May to June 2015 at Dabat Health and Demographic Surveillance System (HDSS) site...
December 19, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29244748/design-of-new-generation-usable-forms-of-topical-haemostatic-agents-containing-chitosan
#10
Dorota Zielińska, Marcin H Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona, Kinga Brzoza-Malczewska
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29209314/probiotic-strain-lactobacillus-casei-bl23-prevents-colitis-associated-colorectal-cancer
#11
Elsa Jacouton, Florian Chain, Harry Sokol, Philippe Langella, Luis G Bermúdez-Humarán
The gut microbiota plays a major role in intestinal health, and an imbalance in its composition can lead to chronic gut inflammation and a predisposition to developing colorectal cancer (CRC). Currently, the use of probiotic bacteria represents an emerging alternative to treat and prevent cancer. Moreover, consumption of these beneficial bacteria may also favorably modulate the composition of the gut microbiota, which has been described in several studies to play an important role in CRC carcinogenesis. In this context, the aim of this study was to assess the protective effect of oral treatment with Lactobacillus casei BL23, a probiotic strain well known for its anti-inflammatory and anticancer properties...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29183394/socio-demographic-factors-and-availability-of-piped-fountains-affect-food-hygiene-practice-of-food-handlers-in-bahir-dar-town-northwest-ethiopia-a-cross-sectional-study
#12
Terefe Derso, Amare Tariku, Fekadu Ambaw, Marew Alemenhew, Gashaw Andargie Biks, Ansha Nega
BACKGROUND: Morbidity and mortality rates of food borne diseases are consistently highest in African due to poor food handling and sanitation practices. Thus, the study aimed to assess food handling practice and associated factors among food handlers of Restaurants in Bahir Dar Town, northwest, Ethiopia. A cross-sectional study was conducted from December, 7/2012 to January, 2/2013 among food handlers working in 106 restaurants in Bahir Dar Town. A structured questionnaire composed of socio-demographic factors, food safety knowledge, working environmental characteristics and food hygiene practice of food handlers was employed to collect the data via interviewing and observations...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29162062/rural-households-at-risk-of-malaria-did-not-own-sufficient-insecticide-treated-nets-at-dabat-hdss-site-evidence-from-a-cross-sectional-re-census
#13
Kindie Fentahun Muchie, Kassahun Alemu, Amare Tariku, Adino Tesfahun Tsegaye, Solomon Mekonnen Abebe, Mezgebu Yitayal, Tadesse Awoke, Gashaw Andargie Biks
BACKGROUND: Malaria is the leading cause of disease burden across the world, especially in African countries. Ethiopia has designed a five year (2011-2015) plan to cover 100% of the households in malarious areas with one insecticide treated net (ITN) for every two persons, and to raise consistent ITN utilization to at least 80%. However, evidence on ownership of ITN among malarious rural households in northwest Ethiopia is quite limited. Hence, the present study aimed at assessing ownership of ITN and associated factors among rural households at risk of malaria at Dabat Health and Demographic Surveillance System site, northwest Ethiopia...
November 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29153320/novel-microbial-diversity-and-functional-potential-in-the-marine-mammal-oral-microbiome
#14
Natasha K Dudek, Christine L Sun, David Burstein, Rose S Kantor, Daniela S Aliaga Goltsman, Elisabeth M Bik, Brian C Thomas, Jillian F Banfield, David A Relman
The vast majority of bacterial diversity lies within phylum-level lineages called "candidate phyla," which lack isolated representatives and are poorly understood. These bacteria are surprisingly abundant in the oral cavity of marine mammals. We employed a genome-resolved metagenomic approach to recover and characterize genomes and functional potential from microbes in the oral gingival sulcus of two bottlenose dolphins (Tursiops truncatus). We detected organisms from 24 known bacterial phyla and one archaeal phylum...
November 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29116650/microbial-biotransformations-in-the-human-distal-gut
#15
REVIEW
Elisabeth M Bik, Juan A Ugalde, Jon Cousins, Audrey D Goddard, Jessica Richman, Zachary S Apte
The human distal gut is home to a rich and dense microbial community with representatives of all three domains of life which are intricately connected with our physiology and health. The combined genomes of these microbes, collectively called the human microbiome, vastly expand the metabolic capacities of our own genome, allowing us to break down and extract energy from dietary compounds that human enzymes cannot digest. In addition, the variable composition of these communities and their biotransformations might explain inter-individual differences in toxicities, tolerances, and efficacies for certain drugs...
November 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29073295/-early-enzyme-replacement-therapy-hope-for-patients-with-mucopolysaccharidosis-type-ii
#16
Karolina Orchel-Szastak, Katarzyna Ptak, Katarzyna Hrnciar, Bożena Pilch, Urszula Kania, Mirosław Bik-Multanowski
We present an unexpected outcome of 10 years of enzyme replacement therapy of a boy with mucopolysaccharidosis type II. Due to a positive familiar history (severe disease course in a sibling) the diagnosis was established in the first month of life. Treatment with Elaprase was introduced two months later. Since then normal physical and mental development is observed. The patient presents only relatively large head circumference (+2.1 SD) and slight decrease of joints mobility. In our opinion, early introduction of enzyme replecement therapy could attenuate the disease course...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29033852/activation-of-casein-kinase-ii-by-gallic-acid-induces-bik-bax-bak-mediated-er-ca-ros-dependent-apoptosis-of-human-oral-cancer-cells
#17
Meng-Liang Lin, Shih-Shun Chen
Induction of the generation of endoplasmic reticulum (ER) calcium (Ca(++))-mediated reactive oxygen species (ROS) by gallic acid (GA) has been implicated in the mitochondrial apoptotic death of human oral cancer (OC) cells, but the molecular mechanism by which GA causes ER Ca(++) release of OC cells to undergo cell death remains unclear. Here, we report that GA-induced phosphorylation of B-cell lymphoma 2 (BCL-2)-interacting killer (BIK) (threonine (Thr) 33/Serine (Ser) 35) and p53 (Ser 15 and Ser 392), Bcl-2-associated x protein (BAX)/BCL-2 antagonist killer 1 (BAK) oligomerization on the ER and mitochondria, rising of cytosolic Ca(+)(+) and ROS, cytochrome c (Cyt c) release from the mitochondria, Ψm loss, and apoptosis were suppressed in cells co-treated with a specific inhibitor of casein kinase II (CK II) (4,5,6,7-tetrabromobenzotriazole)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017540/only-half-of-the-mothers-practiced-early-initiation-of-breastfeeding-in-northwest-ethiopia-2015
#18
Amare Tariku, Gashaw Andargie Biks, Molla Mesele Wassie, Abebaw Gebeyehu Worku, Melaku Kindie Yenit
BACKGROUND: Early initiation of breastfeeding has been well-recognized in reducing neonatal mortality; however, it remains sub-optimal in Ethiopia. This study therefore assessed the prevalence of early initiation of breastfeeding and associated factors among mothers with children aged 6-24 months in Dabat Health and Demographic Surveillance System (HDSS) site, northwest Ethiopia, where literature on the issue is markedly scarce. METHODS: This community-based cross-sectional survey was carried out from May to June, 2015, at Dabat HDSS site, Dabat District...
October 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28986568/bik-reduces-hyperplastic-cells-by-increasing-bak-and-activating-dapk1-to-juxtapose-er-and-mitochondria
#19
Yohannes A Mebratu, Ivan Leyva-Baca, Marc G Wathelet, Neal Lacey, Hitendra S Chand, Augustine M K Choi, Yohannes Tesfaigzi
Bik reduces hyperplastic epithelial cells by releasing calcium from endoplasmic reticulum stores and causing apoptosis, but the detailed mechanisms are not known. Here we report that Bik dissociates the Bak/Bcl-2 complex to enrich for ER-associated Bak and interacts with the kinase domain of DAPk1 to form Bik-DAPk1-ERK1/2-Bak complex. Bik also disrupts the Bcl2-IP3R interaction to cause ER Ca(2+) release. The ER-associated Bak interacts with the kinase and calmodulin domains of DAPk1 to increase the contact sites of ER and mitochondria, and facilitate ER Ca(2+) uptake by mitochondria...
October 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28983977/quality-of-dutch-dermatological-guidelines-according-to-agree-ii
#20
R J Borgonjen, S F K Lubeek, C M Bik, J J E van Everdingen
The number of clinical practice guidelines is increasing, but their quality is variable.(1) However, healthcare professionals/users should be able to rely on methodologically sound guidelines that are helpful and applicable in practice. To objectively assess (methodological) guideline quality, experts developed the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument. This article is protected by copyright. All rights reserved.
October 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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