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https://www.readbyqxmd.com/read/29778542/urinary-mitochondrial-dna-level-in-non-diabetic-chronic-kidney-diseases
#1
Pascal Zhongping Wei, Bonnie Ching-Ha Kwan, Kai Ming Chow, Phyllis Mei-Shan Cheng, Cathy Choi-Wan Luk, Ka-Bik Lai, Philip Kam- To Li, Cheuk Chun Szeto
BACKGROUND: Mitochondrial dysfunction plays an important role in the pathogenesis and progression of chronic kidney disease (CKD). We study the relation between urinary mitochondrial DNA (mtDNA) levels and renal dysfunction in non-diabetic CKD. METHODS: We recruited 32 CKD patients (20 had hypertensive nephrosclerosis, 12 had IgA nephropathy). Urinary supernatant mtDNA level was measured and compared to baseline clinical and pathological parameters. The patients were followed 57...
May 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29777274/the-natural-agent-4-vinylphenol-targets-metastasis-and-stemness-features-in-breast-cancer-stem-like-cells
#2
Hoi-Wing Leung, Chun-Hay Ko, Grace Gar-Lee Yue, Ingrid Herr, Clara Bik-San Lau
BACKGROUND AND PURPOSE: Cancer stem-like cells (CSC) are regarded as the source of tumour origins, metastasis and drug resistance, and limits current treatment regimens. Previously, we reported the first study of the anti-angiogenic and anti-tumour activities of 4-vinylphenol. To further examine the therapeutic role of 4-vinylphenol, the inhibitory effects of 4-vinylphenol on cancer stemness, drug resistance and metastasis in breast cancer were investigated in the present study. STUDY DESIGN AND METHODS: We enriched parental MDA-MB-231 cells with CSCs in serum-free medium to give spheroids...
May 18, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29770814/eu-7-zeolite-a-synthetic-bik-type-zeolite-with-high-hydrothermal-stability
#3
Michiel De Prins, Elke Verheyen, Stef Kerkhofs, Andreas Hoffmann, Gina Vanbutsele, Sreeprasanth Pulinthanathu Sree, Sambhu Radhakrishnan, Leen Van Tendeloo, Eric Breynaert, Christine E A Kirschhock, Frank-Walter Schütze, Johan A Martens
EU-7 zeolite with Si/Al ratio of 15 is identified as a BIK type zeolite. The framework charge is compensated with Cs+ cations located in 8-ring channels at regular distances. Even partially exchanged, Cu-loaded EU-7 is active in NH3-SCR and withstands hydrothermal aging at 900 °C needed for application in diesel particulate filters.
May 17, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29698744/hyperoxia-induces-epigenetic-changes-in-newborn-mice-lungs
#4
Miroslaw Bik-Multanowski, Cecilie Revhaug, Agnieszka Grabowska, Artur Dobosz, Anna Madetko-Talowska, Magdalena Zasada, Ola Didrik Saugstad
Supplemental oxygen exposure is a risk factor for the development of bronchopulmonary dysplasia (BPD). Reactive oxygen species may damage lung tissue, but hyperoxia also has the potential to alter genome activity via changes in DNA methylation. Understanding the epigenetic potential of hyperoxia would enable further improvement of the therapeutic strategies for BPD. Here we aimed to identify hyperoxia-related alterations in DNA methylation, which could affect the activity of crucial genetic pathways involved in the development of hyperoxic lung injury...
June 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29686981/self-sampling-for-human-papillomavirus-testing-increased-cervical-cancer-screening-participation-and-incorporation-in-international-screening-programs
#5
REVIEW
Sarah Gupta, Christina Palmer, Elisabeth M Bik, Juan P Cardenas, Harold Nuñez, Laurens Kraal, Sara W Bird, Jennie Bowers, Alison Smith, Nathaniel A Walton, Audrey D Goddard, Daniel E Almonacid, Susan Zneimer, Jessica Richman, Zachary S Apte
In most industrialized countries, screening programs for cervical cancer have shifted from cytology (Pap smear or ThinPrep) alone on clinician-obtained samples to the addition of screening for human papillomavirus (HPV), its main causative agent. For HPV testing, self-sampling instead of clinician-sampling has proven to be equally accurate, in particular for assays that use nucleic acid amplification techniques. In addition, HPV testing of self-collected samples in combination with a follow-up Pap smear in case of a positive result is more effective in detecting precancerous lesions than a Pap smear alone...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29676772/functional-roles-of-eriocalyxin-b-in-zebrafish-revealed-by-transcriptome-analysis
#6
Xunian Zhou, Cyanne Ye Cao, Angel Tsz-Yau Wan, Grace Gar-Lee Yue, Frankie Hin-Fai Kwok, Kwok-Pui Fung, Handong Sun, Clara Bik-San Lau, Pema-Tenzin Puno, Stephen Kwok-Wing Tsui
BACKGROUND: Eriocalyxin B (EriB) is a natural ent-kaurane diterpenoid obtained from Isodon eriocalyx var. laxiflora (family Lamiaceae), which has multiple biological activities (e.g. anti-tumor and anti-inflammatory) via the alteration of gene expression and signaling transduction. Recently, RNA sequencing (RNA-seq) has been developed as a dynamic transcriptome approach to analyze the transcriptional profile and in addition use such gene expression profiles to identify novel candidate genes in a zebrafish model...
June 12, 2018: Molecular omics
https://www.readbyqxmd.com/read/29665555/hesperidin-promotes-programmed-cell-death-by-downregulation-of-nongenomic-estrogen-receptor-signalling-pathway-in-endometrial-cancer-cells
#7
Z B Cincin, B Kiran, Y Baran, B Cakmakoglu
Endometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29663902/causal-beliefs-affect-treatment-practices-and-preferences-for-neonatal-danger-signs-in-northwest-ethiopia-a-qualitative-study
#8
Tariku Nigatu Bogale, Abebaw Gebeyehu Worku, Alemayehu Worku Yalew, Gashaw Andargie Biks, Zemene Tigabu Kebede
This study was conducted to explore the experiences of community members, particularly mothers, concerning their beliefs about the causes, treatment practices, and preferences for World Health Organization-defined neonatal danger signs in northwest Ethiopia. A phenomenological qualitative study was conducted in three districts of north Gondar Zone, Amhara region, Ethiopia, from March 10 to 28, 2016. Twelve focus group discussions were conducted involving 98 individuals. In-depth interviews were conducted with six health extension workers and 30 women who were either pregnant or who delivered in the past 6 months...
June 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#9
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29600535/nematode-associated-microbial-taxa-do-not-correlate-with-host-phylogeny-geographic-region-or-feeding-morphology-in-marine-sediment-habitats
#10
Taruna Schuelke, Tiago José Pereira, Sarah M Hardy, Holly M Bik
Studies of host-associated microbes are critical for advancing our understanding of ecology and evolution across diverse taxa and ecosystems. Nematode worms are ubiquitous across most habitats on earth, yet little is known about host-associated microbial assemblages within the phylum. Free-living nematodes are globally abundant and diverse in marine sediments, with species exhibiting distinct buccal cavity (mouth) morphologies that are thought to play an important role in feeding ecology and life history strategies...
April 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29577460/gene-expression-profiling-reveals-the-plausible-mechanisms-underlying-the-antitumor-and-antimetastasis-effects-of-andrographis-paniculata-in-esophageal-cancer
#11
Lin Li, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Eric Chun-Wai Wong, Kwok-Pui Fung, Jun Yu, Clara Bik-San Lau, Philip Wai-Yan Chiu
Esophageal cancer (EC) is a seriously invasive malignancy with high mortality and poor prognosis. Metastasis of EC is the major cause of mortality. Our studies previously demonstrated that a herbal medicine Andrographis paniculata (AP) significantly suppressed EC growth and metastasis in vitro and in vivo. However, the underlying mechanisms responsible for these effects have not yet been systematically elucidated. In this context, gene expression profiling of AP-treated squamous EC cells (EC-109) was performed to reveal the regulatory mechanisms of AP in antitumor and antimetastasis signaling pathways using gene expression microarray analysis...
March 26, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29566767/methotrexate-upregulates-circadian-transcriptional-factors-par-bzip-to-induce-apoptosis-on-rheumatoid-arthritis-synovial-fibroblasts
#12
Kohjin Suzuki, Kohsuke Yoshida, Takeshi Ueha, Kenta Kaneshiro, Ayako Nakai, Naonori Hashimoto, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Natsuko Nakagawa, Yoshitada Sakai, Akira Hashiramoto
BACKGROUND: Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) synovial fibroblasts are incompletely understood. We explored actions of MTX in view of circadian transcriptions of synovial fibroblasts. METHODS: Under treatment with MTX, expression of core circadian clock genes, circadian transcriptional factor proline and acidic amino acid-rich basic leucine zipper (PAR bZIP), and proapoptotic molecule Bcl-2 interacting killer (Bik) was examined by real-time polymerase chain reaction...
March 22, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29535391/molecular-typing-of-mycobacterium-kansasii-using-pulsed-field-gel-electrophoresis-and-a-newly-designed-variable-number-tandem-repeat-analysis
#13
Zofia Bakuła, Anna Brzostek, Paulina Borówka, Anna Żaczek, Izabela Szulc-Kiełbik, Agata Podpora, Paweł Parniewski, Dominik Strapagiel, Jarosław Dziadek, Małgorzata Proboszcz, Jacek Bielecki, Jakko van Ingen, Tomasz Jagielski
Molecular epidemiological studies of Mycobacterium kansasii are hampered by the lack of highly-discriminatory genotyping modalities. The purpose of this study was to design a new, high-resolution fingerprinting method for M. kansasii. Complete genome sequence of the M. kansasii ATCC 12478 reference strain was searched for satellite-like repetitive DNA elements comprising tandem repeats. A total of 24 variable-number tandem repeat (VNTR) loci were identified with potential discriminatory capacity. Of these, 17 were used to study polymorphism among 67 M...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29471744/injury-related-gaining-momentum-as-external-causes-of-deaths-in-ethiopian-health-and-demographic-surveillance-sites-evidence-from-verbal-autopsy-study
#14
Kassahun Alemu Gelaye, Fasil Tessema, Befikadu Tariku, Semaw Ferede Abera, Alemseged Aregay Gebru, Nega Assefa, Desalew Zelalem, Melkamu Dedefo, Mekdes Kondal, Mesfin Kote, Mitike Molla Sisay, Wubegzier Mekonnen, Mamo Wubshet Terefe, Gashaw Andargie Biks, Firehywot Eshetu, Mulumebet Abera, Yoseph Fekadu, Gessessew Bugssa Hailu, Etsehiwot Tilahun, Yihunie Lakew
BACKGROUND: In Ethiopia, though all kinds of mortality due to external causes are an important component of overall mortality often not counted or documented on an individual basis. OBJECTIVE: The aim of this study was to describe the patterns of mortality from external causes using verbal autopsy (VA) method at the Ethiopian HDSS Network sites. METHODS: All deaths at Ethiopian HDSS sites were routinely registered and followed up with VA interviews...
2018: Global Health Action
https://www.readbyqxmd.com/read/29460082/testing-hypotheses-on-risk-factors-for-scientific-misconduct-via-matched-control-analysis-of-papers-containing-problematic-image-duplications
#15
Daniele Fanelli, Rodrigo Costas, Ferric C Fang, Arturo Casadevall, Elisabeth M Bik
It is commonly hypothesized that scientists are more likely to engage in data falsification and fabrication when they are subject to pressures to publish, when they are not restrained by forms of social control, when they work in countries lacking policies to tackle scientific misconduct, and when they are male. Evidence to test these hypotheses, however, is inconclusive due to the difficulties of obtaining unbiased data. Here we report a pre-registered test of these four hypotheses, conducted on papers that were identified in a previous study as containing problematic image duplications through a systematic screening of the journal PLoS ONE...
February 19, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29454618/natural-small-molecule-bigelovin-suppresses-orthotopic-colorectal-tumor-growth-and-inhibits-colorectal-cancer-metastasis-via-il6-stat3-pathway
#16
Mingyue Li, Grace Gar-Lee Yue, Li-Hua Song, Mao-Bo Huang, Julia Kin-Ming Lee, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Ning-Hua Tan, Clara Bik-San Lau
Bigelovin, a sesquiterpene lactone, has been demonstrated to induce apoptosis, inhibit inflammation and angiogenesis in vitro, but its potential anti-metastatic activity remains unclear. In the present study, two colon cancer mouse models, orthotopic tumor allografts and experimental metastatic models were utilized to investigate the progression and metastatic spread of colorectal cancer after bigelovin treatments. Results showed that bigelovin (intravenous injection; 0.3-3 mg/kg) significantly suppressed tumor growth and inhibited liver/lung metastasis with modulation of tumor microenvironment (e...
April 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29426265/molecular-karyotyping-in-early-miscarriages-potential-for-the-routine-use-of-cytogenetic-microarrays
#17
Katarzyna Szewczyk, Miroslaw Bik-Multanowski
No abstract text is available yet for this article.
February 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29425850/neuroprotective-effect-of-da-chuanxiong-formula-against-cognitive-and-motor-deficits-in-a-rat-controlled-cortical-impact-model-of-traumatic-brain-injury
#18
Zhi-Ke Liu, Chun-Fai Ng, Hoi-Ting Shiu, Hing-Lok Wong, Wai-Ching Chin, Jin-Fang Zhang, Ping-Kuen Lam, Wai-Sang Poon, Clara Bik-San Lau, Ping-Chung Leung, Chun-Hay Ko
ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCXF) is one of the famous herb pairs that contains dried rhizomes of Ligusticum chuanxiong Hort. and Gastrodia elata Bl. in the mass ratio of 4:1. This classic representative traditional Chinese medicine has been widely used to treat brain diseases like headache and migraine caused by blood stasis and wind pathogen. However, the therapeutic effect of DCXF on traumatic brain injury (TBI) has not been reported yet. AIM OF STUDY: The present study was performed to investigate the neuroprotective effects of DCXF and its underlying mechanisms in the controlled cortical impact (CCI)-induced TBI rat model...
May 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29372685/dna-methylation-as-mechanism-of-apoptotic-resistance-development-in-endometrial-cancer-patients
#19
MULTICENTER STUDY
Veronika Fialkova, Eva Vidomanova, Tomas Balharek, Juraj Marcinek, Erik Kudela, Sandra Hanysova, Jozef Visnovsky, Dusan Dobrota, Jozef Hatok
DNA methylation is a significant epigenetic modification which plays a key role in regulation of gene expression and influences functional changes in endometrial tissue. Aberrant DNA methylation changes result in deregulation of important apoptotic proteins during endometrial carcinogenesis and apoptosis resistance development. Evading apoptosis is still a major problem in the successful treatment of endometrial cancer patients. The aim of our study was to examine the promoter DNA methylation changes in 22 apoptosis-associated genes in endometrioid endometrial cancer patients, precancerous lesions and healthy tissue from various normal menstrual cycle phases using a unique pre-designed methylation platform...
December 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29363243/a-cohort-study-assessing-the-impact-of-small-volume-blood-tubes-on-diagnostic-test-quality-and-iatrogenic-blood-loss-in-a-cohort-of-adult-haematology-patients
#20
Nicholas Myles, Jacoba von Wielligh, Mario Kyriacou, Terry Ventrice, Luen Bik To
OBJECTIVES: to estimate the reduction in blood volume loss and diagnostic test quality associated with introduction of small volume blood tubes in a cohort of haematology inpatients compared to a historical comparator group. DESIGN: prospective cohort study. SETTING: haematology unit of a tertiary referral hospital in Adelaide. PARTICIPANTS: haematology inpatients. INTERVENTION: small volume blood tubes were used in an intervention cohort admitted between 2012-2013 and compared to a control cohort admitted between 2009-2010 where standard volume tubes had been used...
January 24, 2018: Internal Medicine Journal
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