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https://www.readbyqxmd.com/read/28106988/factors-governing-the-performance-of-bauxite-for-fluoride-remediation-of-groundwater
#1
Aruna Kirani Katyayani Cherukumilli, Caroline Delaire, Susan E Amrose, Ashok J Gadgil
Globally, 200 million people drink groundwater contaminated with fluoride concentrations exceeding the World Health Organization's recommended level (WHO-MCL =1.5 mg F-/L). This study investigates the use of minimally-processed (dried/milled) bauxite ore as an inexpensive adsorbent for remediating fluoride-contaminated groundwater in resource-constrained areas. Adsorption experiments in synthetic groundwater using bauxites from Guinea, Ghana, USA, and India as single-use batch dispersive media demonstrated that doses of ~10-23 g/L could effectively remediate 10 mg F-/L...
January 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28105237/xanthohumol-inhibits-proliferation-of-laryngeal-squamous-cell-carcinoma
#2
Yan Li, Kai Wang, Shankai Yin, Hongliang Zheng, Daliu Min
Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and to understand the mechanism of its action. The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, the expression levels of pro-apoptotic proteins, caspase-3, caspase-8, caspase-9, poly ADP ribose polymerase (PARP) p53 and apoptosis-inducing factor (AIF), as well as anti-apoptotic markers, B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1), were analyzed by western blotting...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28088782/pde5-inhibitors-enhance-the-lethality-of-pemetrexed-sorafenib
#3
Laurence Booth, Jane L Roberts, Andrew Poklepovic, Paul Dent
The combination of pemetrexed and sorafenib has significant clinical activity against a wide variety of tumor types in patients and the present studies were performed to determine whether sildenafil enhances the killing potential of [pemetrexed + sorafenib]. In multiple genetically diverse lung cancer cell lines, sildenafil enhanced the lethality of [pemetrexed + sorafenib]. The three-drug combination reduced the activities of AKT, mTOR and STAT transcription factors; increased the activities of eIF2α and ULK-1; lowered the expression of MCL-1, BCL-XL, thioredoxin and SOD2; and increased the expression of Beclin1...
January 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28079887/drp-1-is-required-for-bh3-mimetic-mediated-mitochondrial-fragmentation-and-apoptosis
#4
Mateus Milani, Dominic P Byrne, Georgia Greaves, Michael Butterworth, Gerald M Cohen, Patrick A Eyers, Shankar Varadarajan
The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as Navitoclax and Venetoclax, in treating BCL-2-dependent haematological malignancies. However, most solid tumours depend on MCL-1 for survival, which is highly amplified in multiple cancers and a major factor determining chemoresistance. Most MCL-1 inhibitors that have been generated so far, while demonstrating early promise in vitro, fail to exhibit specificity and potency in a cellular context...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28079103/erratum-antigen-affinity-controls-pre-germinal-center-b-cell-selection-by-promoting-mcl-1-induction-through-baff-receptor-signaling
#5
Felix M Wensveen, Erik Slinger, Martijn Ha van Attekum, Robert Brink, Eric Eldering
No abstract text is available yet for this article.
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069035/fbw7-regulates-apoptosis-in-activated-b-cell-like-diffuse-large-b-cell-lymphoma-by-targeting-stat3-for-ubiquitylation-and-degradation
#6
Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu, Yanhui Liu
BACKGROUND: The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear. METHODS: We evaluated Fbw7 expression in patient samples of DLBCL using immunohistochemical staining. The effect of Fbw7 overexpression on cell viability and apoptosis was investigated using activated B-cell (ABC) like DLBCL cell lines. The mechanism of Fbw7 activity in DLBCL was investigated using immunoprecipitation, ubiquitination, western blot and qualitative analyses...
January 10, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28063408/creb-knockdown-inhibits-growth-and-induces-apoptosis-in-human-pre-b-acute-lymphoblastic-leukemia-cells-through-inhibition-of-prosurvival-signals
#7
Rima Manafi Shabestari, Majid Safa, Fatemeh Alikarami, Mehdi Banan, Ahmad Kazemi
A majority of acute lymphoblastic leukemia patients overexpress CREB in the bone marrow. However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect of CREB on the growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells has not been elucidated. We demonstrated here that CREB knockdown induced apoptosis and impaired growth of BCP-ALL NALM-6 cells which was associated with caspase activation. The gene expression levels of prosurvival signals Bcl-2, Mcl-1, Bcl-xL, survivin and XIAP were down-regulated upon CREB suppression...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28052347/apoptotic-effects-of-bovine-apo-lactoferrin-on-hela-tumor-cells
#8
Carla Luzi, Fabrizia Brisdelli, Roberto Iorio, Argante Bozzi, Veronica Carnicelli, Antonio Di Giulio, Anna Rita Lizzi
Lactoferrin (Lf), a cationic iron-binding glycoprotein of 80 kDa present in body secretions, is known as a compound with marked antimicrobial activity. In the present study, the apoptotic effect of iron-free bovine lactoferrin (apo-bLf) on human epithelial cancer (HeLa) cells was examined in association with reactive oxygen species and glutathione (GSH) levels. Apoptotic effect of iron-free bovine lactoferrin inhibited the growth of HeLa cells after 48 hours of treatment while the diferric-bLf was ineffective in the concentration range tested (from 1 to 12...
January 3, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28039357/key-survival-factor-mcl-1-correlates-with-sensitivity-to-combined-bcl-2-bcl-xl-blockade
#9
Michelle Williams, Linus Lee, Donna J Hicks, Meghan M Joly, David Elion, Bushra Rahman, Courtney McKernan, Violeta Sanchez, Justin M Balko, Thomas Stricker, Monica Valeria Estrada, Rebecca S Cook
: An estimated 40,000 deaths will be attributed to breast cancer in 2016, underscoring the need for improved therapies. Evading cell death is a major hallmark of cancer, driving tumor progression and therapeutic resistance. To evade apoptosis, cancers use anti-apoptotic Bcl-2 proteins to bind to and neutralize apoptotic activators, such as Bim. Investigation of anti-apoptotic Bcl-2 family members in clinical breast cancer datasets, revealed greater expression and more frequent gene amplification of MCL1 as compared to BCL2 or BCL2L1 (Bcl-xL) across three major molecular breast cancer subtypes, Luminal (A and B), HER2-enriched, and Basal-like...
December 30, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28038464/mcl-1-expression-and-jnk-activation-induces-a-threshold-for-apoptosis-in-bcl-xl-overexpressing-hematopoietic-cells
#10
Yu Zhang, Xin Li, Shisheng Tan, Xinyu Liu, Xinyu Zhao, Zhu Yuan, Chunlai Nie
The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death in hematopoietic cancer cells with high Bcl-xL expression. Here, we demonstrate that 2-deoxyglucose (2-DG) enhanced the effect of ABT-199 to induce cell apoptosis in hematologic malignancies with up-regulated Bcl-xL expression. Our study revealed that 2-DG could decrease glucose-dependent and Akt-independent Mcl-1 expression, which is mediated by the mechanistic target of rapamycin complex 1 (mTORC1) pathway...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28036295/identification-of-mtor-as-a-primary-resistance-factor-of-the-iap-antagonist-at406-in-hepatocellular-carcinoma-cells
#11
Mao-Chuan Zhen, Fu-Qiang Wang, Shao-Feng Wu, Yi-Lin Zhao, Ping-Guo Liu, Zhen-Yu Yin
Dysregulation of inhibitor of apoptosis (IAP) proteins (IAPs) in hepatocellular carcinoma (HCC) is often associated with poor prognosis. Here we showed that AT406, an IAP antagonist, was cytotoxic and pro-apoptotic to both established (HepG2, SMMC-7721 lines) and primary HCC cells. Activation of mTOR could be a key resistance factor of AT406 in HCC cells. mTOR inhibition (by OSI-027), kinase-dead mutation or knockdown remarkably enhanced AT406-induced lethality in HCC cells. Reversely, forced-activation of mTOR by adding SC79 or exogenous expressing a constitutively active S6K1 (T389E) attenuated AT406-induced cytotoxicity against HCC cells...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035065/zgdhu-1-promotes-apoptosis-of-mantle-cell-lymphoma-cells
#12
Liannv Qiu, Jinlin Liu, Zhenni Wang, Sufeng Chen, Weixiao Hu, Qiang Huang, Yonglie Zhou
Mantle cell lymphoma (MCL) is a well-defined aggressive Non-Hodgkin-lymphoma with short survival rates and remains incurable to date. Previously, we demonstrated the antitumor activity of ZGDHu-1(N, N'-di-(m-methylphenyi)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide) in chronic lymphocytic leukemia. In this study, ZGDHu-1 shows potent anti-lymphoma activity in MCL cells. ZGDHu-1 significantly induces cell cycle G2/M phase arrest and apoptosis in MCL cells. ZGDHu-1 reduces the protein levels of Mcl-1, Bcl-XL and cyclin D1...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031117/-knockdown-of-myeloid-cell-leukemia-1-gene-inhibits-the-proliferation-and-promotes-apoptosis-of-prostate-cancer-cells
#13
Xia Yang, Rui Wang, Kai Xu, Fan Yang, Yanbin Chen, Zhi Zuo, Bin Song
Objective To detect the protein expression level of human myeloid cell leukemia 1 (MCL-1) gene in prostate cancer and its effect on the prognosis of prostate cancer. Methods MCL-1 protein expression was detected by immunohistochemistry in 517 cases of prostate cancer tissues and the corresponding adjacent tissues. The correlation was analyzed statistically between the expression level and the prognosis of prostate cancer patients. In addition, after the expression of human MCL-1 protein in prostate cancer cell line was interfered, MTT assay, clone formation assay and TUNEL assay were performed to test the ability of cell proliferation and apoptosis...
January 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28030835/co-targeting-translation-and-proteasome-rapidly-kills-colon-cancer-cells-with-mutant-ras-raf-via-er-stress
#14
Xiangyun Li, Mei Li, Hang Ruan, Wei Qiu, Xiang Xu, Lin Zhang, Jian Yu
Colorectal cancers with mutant RAS/RAF are therapy refractory. Deregulated mRNA translation has become an emerging target in cancer treatment. We recently reported that mTOR inhibitors induce apoptosis via ER stress and the extrinsic pathway upon acute inhibition of the eIF4F complex in colon cancer cells and xenografts, while mutant BRAF600E leads to therapeutic resistance via ERK-mediated Mcl-1 stabilization. In this study, we demonstrated that several other translation inhibitors also activate ER stress and the extrinsic apoptotic pathway...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/28026162/hbfl-1-hnoxa-interaction-studies-provide-new-insights-on-the-role-of-bfl-1-in-cancer-cell-resistance-and-for-the-design-of-novel-anticancer-agents
#15
Elisa Barile, Guya D Marconi, Surya K De, Carlo Baggio, Luca Gambini, Ahmed F Salem, Manoj K Kashyap, Januario E Castro, Thomas J Kipps, Maurizio Pellecchia
Upregulation of antiapoptotic Bcl-2 proteins in certain tumors confers cancer cell resistance to chemotherapy or radiations. Members of the antiapoptotic Bcl-2 proteins, including Bcl-2, Mcl-1, Bcl-xL, Bcl-w, and Bfl-1, inhibit apoptosis by selectively binding to conserved α-helical regions, named BH3 domains, of pro-apoptotic proteins such as Bim, tBid, Bad, or NOXA. Five antiapoptotic proteins have been identified that interact with various selectivity with BH3 containing pro-apoptotic counterparts. Cancer cells present various and variable levels of these proteins, making the design of effective apoptosis based therapeutics challenging...
December 27, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/28025107/apigenin-potentiates-the-antitumor-activity-of-5-fu-on-solid-ehrlich-carcinoma-crosstalk-between-apoptotic-and-jnk-mediated-autophagic-cell-death-platforms
#16
Hanaa H Gaballah, Rasha A Gaber, Darin A Mohamed
BACKGROUND: Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. AIM: This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). METHODS: Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC+5-FU, SEC+apigenin, SEC+ 5-FU+apigenin...
December 23, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28024471/-combination-of-homoharringtonine-with-arsenic-trioxide-induces-apoptosis-of-human-acute-myeloid-leukemia-cell-line-u937
#17
Ping Chen, Xi Jiang, Pei-Dong You, Qing Jin, Qin Yuan, Hui-Fang Huang
OBJECTIVE: To investigate the effects and mechanisms of the combination of homoharringtonine (HHT) with arsenic trioxide(As2O3) on human myeloid cell line U937 in vitro. METHODS: MTT method was used to determine the antiproliferating effect of different concentrations of HHT, As2O3 and their combination on U937 cells; the flow cytometry with Annexin-V-FITC/PI double staining was used to determine the apoptosis-induced effect of HHT and As2O3 alone or their combination; Western blot method was used to detect the protein expression of P-Akt(Ser473),P-Akt(Thr308),BCL-XL, BID,MCL-1,P-MCL-1 and so on...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28024402/relative-binding-free-energy-calculations-applied-to-protein-homology-models
#18
Daniel Cappel, Michelle Lynn Hall, Eelke B Lenselink, Thijs Beuming, Jun Qi, James Bradner, Woody Sherman
A significant challenge and potential high-value application of computer-aided drug design is the accurate prediction of protein-ligand binding affinities. Free energy perturbation (FEP) using molecular dynamics (MD) sampling is among the most suitable approaches to achieve accurate binding free energy predictions, due to the rigorous statistical framework of the methodology, correct representation of the energetics, and thorough treatment of the important degrees of freedom in the system (including explicit waters)...
December 27, 2016: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/27999204/mesothelin-targeted-immunotoxin-rg7787-has-synergistic-anti-tumor-activity-when-combined-with-taxanes
#19
Emily Kolyvas, Michael Rudloff, Marianne Poruchynsky, Rebekah Landsman, Kevin Hollevoet, David Venzon, Christine Alewine
Recombinant immunotoxins (RITs) are antibody-based therapeutics that carry a toxin payload. The RG7787 RIT targets the cancer antigen mesothelin to deliver a recombinantly-engineered, reduced immunogenicity variant of Pseudomonas exotoxin A (PE) to the cytosol where it inhibits protein synthesis. Here we demonstrate that maximal doses of RG7787 temporarily halt growth of pancreatic cancer tumor xenografts, similar to the approved drugs gemcitabine and nab-paclitaxel, however, combination of the RIT with nab-paclitaxel produces durable complete regressions in most mice...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27997878/design-and-synthesis-of-novel-2-substituted-11-keto-boswellic-acid-heterocyclic-derivatives-as-anti-prostate-cancer-agents-with-pin1-inhibition-ability
#20
Kun Li, Lei Li, Shuxiang Wang, Xiaojing Li, Tianyi Ma, Dan Liu, Yongkui Jing, Linxiang Zhao
A series of novel acetyl-11-keto-β-boswellic acid (AKBA) derivatives with a different electron-withdrawing group on ring A and a nitrogen heterocycle at C-24 were designed and synthesized. These semi-synthetic compounds showed improved anti-proliferative activity against prostate cancer cells over AKBA. Compound 8f bearing 2-cyano-3,11-dioxo moiety and piperazine was the most potent to inhibit growth of prostate cancer PC-3 (IC50 = 0.04 μM) and LNCaP (IC50 = 0.27 μM) cell lines. 8f caused cell cycle arrest in G2/M and induced apoptosis...
September 28, 2016: European Journal of Medicinal Chemistry
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