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https://www.readbyqxmd.com/read/29053589/structural-and-functional-insight-into-canarypox-virus-cnp058-mediated-regulation-of-apoptosis
#1
Mohd Ishtiaq Anasir, Amy A Baxter, Ivan K H Poon, Mark D Hulett, Marc Kvansakul
Programmed cell death or apoptosis is an important component of host defense systems against viral infection. The B-cell lymphoma 2 (Bcl-2) proteins family is the main arbiter of mitochondrially mediated apoptosis, and viruses have evolved sequence and structural mimics of Bcl-2 to subvert premature host cell apoptosis in response to viral infection. The sequencing of the canarypox virus genome identified a putative pro-survival Bcl-2 protein, CNP058. However, a role in apoptosis inhibition for CNP058 has not been identified to date...
October 20, 2017: Viruses
https://www.readbyqxmd.com/read/29048129/realgar-nanoparticles-versus-ato-arsenic-compounds-induce-in%C3%A2-vitro-and-in%C3%A2-vivo-activity-against-multiple-myeloma
#2
Danka Cholujova, Zdenka Bujnakova, Erika Dutkova, Teru Hideshima, Richard W Groen, Constantine S Mitsiades, Paul G Richardson, David M Dorfman, Peter Balaz, Kenneth C Anderson, Jana Jakubikova
Multiple myeloma (MM), a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow, remains incurable despite the use of novel and conventional therapies. In this study, we demonstrated MM cell cytotoxicity triggered by realgar (REA; As4 S4 ) nanoparticles (NREA) versus Arsenic trioxide (ATO) against MM cell lines and patient cells. Both NREA and ATO showed in vivo anti-MM activity, resulting in significantly decreased tumour burden. The anti-MM activity of NREA and ATO is associated with apoptosis, evidenced by DNA fragmentation, depletion of mitochondrial membrane potential, cleavage of caspases and anti-apoptotic proteins...
October 19, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29043499/open-circuit-respirometry-a-historical-review-of-portable-gas-analysis-systems
#3
REVIEW
Duncan J Macfarlane
Scientists such as physiologists, engineers, and nutritionists have often sought to estimate human metabolic strain during daily activities and physical pursuits. The measurement of human metabolism can involve direct calorimetry as well as indirect calorimetry using both closed-circuit respirometry and open-circuit methods that can include diluted flow chambers and laboratory-based gas analysis systems. For field studies, methods involving questionnaires, pedometry, accelerometery, heart rate telemetry, and doubly labelled water exist, yet portable metabolic gas analysis remains the gold standard for most field studies on energy expenditure...
October 17, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29030732/deguelin-induces-puma-mediated-apoptosis-and-promotes-sensitivity-of-lung-cancer-cells-lccs-to-doxorubicin-dox
#4
Aimei Wang, Weina Wang, Yaqi Chen, Fengqiao Ma, Xiaoming Wei, Yongyi Bi
As a natural agent for chemotherapy, deguelin remarkably suppresses proliferation in numerous solid cancers. Nevertheless, the molecular mechanisms of its suppression are still insufficient. In our research, it was revealed that deguelin induced cell death of lung cancer cells (LCCs) by triggering expression of PUMA. Deguelin triggered PUMA induction independently of p53 via suppression of PI3K/AKT pathway, therefore stimulating Foxo3a to bind with PUMA promoter and stimulate its transcription. Subsequent to activation, PUMA motivated Bax as well as the intrinsic mitochondrial cell death pathway...
October 13, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29026880/adaptive-social-strategies-in-a-solitary-carnivore
#5
L Mark Elbroch, Michael Levy, Mark Lubell, Howard Quigley, Anthony Caragiulo
Cost-benefit trade-offs for individuals participating in social behaviors are the basis for current theories on the evolution of social behaviors and societies. However, research on social strategies has largely ignored solitary animals, in which we assume that rare interactions are explained by courtship or territoriality or, in special circumstances, resource distributions or kinship. We used directed network analysis of conspecific tolerance at food sources to provide evidence that a solitary carnivore, the puma (Puma concolor), exhibited adaptive social strategies similar to more social animals...
October 2017: Science Advances
https://www.readbyqxmd.com/read/29024157/regulation-of-nonylphenol-induced-reproductive-toxicity-in-mouse-spermatogonia-cells-by-mir-361-3p
#6
Liyan Tang, Bo Zhao, Hui Zhang, Qiao Du, Jiang Zhu, Zhijiang Zhao, Ce Chen, Cheng Luo, Qiyuan Kang, Wenbing Yuan, Shaohua Bian, Hang Bi, Huimin Sun, Yingyi Li
Nonylphenol (NP) is an environmental chemical that affects apoptosis and male infertility. In our study, we found that a high concentration of NP could down-regulate the expression of microRNA-361-3p (miR-361-3p) in the murine GC-1 spermatogonia cell line and in vivo in murine spermatogonia. Additionally, one direct target of this miR, the 3' untranslated region of Killin (Klln) mRNA, was identified. Klln encodes a transcription factor that directly regulates the expression of Tp73 (transcriptionally active p73), whose encoded protein can up-regulate the expression of Puma (P53 upregulated modulator of apoptosis)...
October 12, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29022904/zika-virus-infection-dysregulates-human-neural-stem-cell-growth-and-inhibits-differentiation-into-neuroprogenitor-cells
#7
Pradip Devhare, Keith Meyer, Robert Steele, Ratna B Ray, Ranjit Ray
The current outbreak of Zika virus-associated diseases in South America and its threat to spread to other parts of the world has emerged as a global health emergency. A strong link between Zika virus and microcephaly exists, and the potential mechanisms associated with microcephaly are under intense investigation. In this study, we evaluated the effect of Zika virus infection of Asian and African lineages (PRVABC59 and MR766) in human neural stem cells (hNSCs). These two Zika virus strains displayed distinct infection pattern and growth rates in hNSCs...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020087/residential-development-alters-behavior-movement-and-energetics-in-an-apex-predator-the-puma
#8
Yiwei Wang, Justine A Smith, Christopher C Wilmers
Human development strongly influences large carnivore survival and persistence globally. Behavior changes are often the first measureable responses to human disturbances, and can have ramifications on animal populations and ecological communities. We investigated how a large carnivore responds to anthropogenic disturbances by measuring activity, movement behavior, and energetics in pumas along a housing density gradient. We used log-linear analyses to examine how habitat, time of day, and proximity to housing influenced the activity patterns of both male and female pumas in the Santa Cruz Mountains...
2017: PloS One
https://www.readbyqxmd.com/read/29017780/using-theta-and-alpha-band-power-to-assess-cognitive-workload-in-multitasking-environments
#9
Sébastien Puma, Nadine Matton, Pierre-V Paubel, Éric Raufaste, Radouane El-Yagoubi
Cognitive workload is of central importance in the fields of human factors and ergonomics. A reliable measurement of cognitive workload could allow for improvements in human machine interface designs and increase safety in several domains. At present, numerous studies have used electroencephalography (EEG) to assess cognitive workload, reporting the rise in cognitive workload to be associated with increases in theta band power and decreases in alpha band power. However, results have been inconsistent with some failing to reach the required level of significance...
October 7, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29016132/towards-understanding-mcl-1-promiscuous-and-specific-binding-mode
#10
Jade Fogha, Bogdan Marekha, Marcella De Giorgi, Anne Sophie Voisin-Chiret, Sylvain Rault, Ronan Bureau, Jana Sopková-de Oliveira Santos
Mcl-1, an anti-apoptotic member of the Bcl-2 protein family, is overexpressed in various cancers and promotes the aberrant survival of tumour cells. To inhibit Mcl-1, and initiate apoptosis, an interaction between activated BH3-only proteins and Mcl-1 anti-apoptotic protein is necessary. These protein-protein interactions exhibit some selectivity: Mcl-1 binds specifically Noxa, whereas Bim and Puma bind strongly to all anti-apoptotic proteins. Even if the 3D structures of several Mcl-1/BH3-only complexes have been solved, the BH3-only binding specificity to Mcl-1 is still not completely understood...
October 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28986085/ovatodiolide-isolated-from-anisomeles-indica-induces-cell-cycle-g2-m-arrest-and-apoptosis-via-a-ros-dependent-atm-atr-signaling-pathways
#11
Chen-Yuan Yu, Chieh-Lin Jerry Teng, Pei-Shan Hung, Chi-Chih Cheng, Shih-Lan Hsu, Guang-Yuh Hwang, Yew-Min Tzeng
Ovatodiolide was isolated from the traditional Chinese medicinal herb Anisomeles indica, possesses anti-bacterial and anti-inflammatory properties; however, the anti-cancer activity and its mechanisms have been limitedly reported. This study aimed to examine the effect and molecular action of ovatodiolide in lung cancer cells. Cell cycle distribution and reactive oxygen species (ROS) generation were measured by flow cytometry. Apoptosis was detected by propidium iodide/annexin V staining and TUNEL assay. DNA damage was investigated by comet assay and γ-H2AX staining...
October 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28983020/ekert-pg-jabbour-am-manoharan-a-et-al-cell-death-provoked-by-loss-of-interleukin-3-signaling-is-independent-of-bad-bim-and-pi3-kinase-but-depends-in-part-on-puma-blood-2006-108-5-1461-1468
#12
https://www.readbyqxmd.com/read/28977471/variations-in-gene-expression-of-lung-macromolecules-after-induction-chemotherapy-for-lung-cancer
#13
Lucio Cagini, Stefania Balloni, Vienna Ludovini, Marco Andolfi, Alberto Matricardi, Rossella Potenza, Jacopo Vannucci, Annamaria Siggillino, Francesca Romana Tofanetti, Guido Bellezza, Maria Bodo, Francesco Puma, Lorella Marinucci
OBJECTIVES: Preoperative chemotherapy may play a role in postoperative respiratory complications due to subclinical parenchymal damage. We investigated the gene expression of lung tissue components after neoadjuvant chemotherapy of alveolar-capillary membrane, extracellular matrix and membrane proteins. METHODS: The study group included 14 patients submitted to pulmonary resection for lung cancer after 3 cycles of gemcitabine-cisplatin, while the control group included 14 naive-treatment patients...
June 19, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28970172/plasmid-pum505-encodes-a-toxin-antitoxin-system-conferring-plasmid-stability-and-increased-pseudomonas-aeruginosa-virulence
#14
K C Hernández-Ramírez, V M Chávez-Jacobo, M I Valle-Maldonado, J A Patiño-Medina, S P Díaz-Pérez, I E Jácome-Galarza, R Ortiz-Alvarado, V Meza-Carmen, M I Ramírez-Díaz
Pseudomonas aeruginosa plasmid pUM505 possesses a pathogenicity island that contains the pumAB genes that encode products with sequence similarity to Toxin-Antitoxin (TA) modules. RT-PCR assays on the overlapping regions of the pumAB genes generated a bicistronic messenger RNA, suggesting that they form an operon. When the pumAB genes were cloned into the pJET vector, recombinant plasmid pJET-pumAB was maintained under nonselective conditions in Escherichia coli cells after six daily subcultures, whereas pJET without pumAB genes was lost...
September 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28968756/resistance-mediated-by-alternative-receptor-tyrosine-kinases-in-fgfr1-amplified-lung-cancer
#15
Yuta Adachi, Kazuyoshi Watanabe, Kenji Kita, Hidenori Kitai, Hiroshi Kotani, Yuki Sato, Naohiko Inase, Seiji Yano, Hiromichi Ebi
FGFR1 amplification has been identified in 10%-20% of patients with squamous non-small cell lung cancer. Preclinical models showed promising activity of specific FGFR inhibitors, but early clinical trials showed that only a small fraction of patients with FGFR1-amplified lung cancer responded to FGFR inhibitors. These unsatisfactory results were partly explained by heterogeneous amplicons around the 8p11 genomic region, leading to false positive amplification results. Furthermore, discrepancies in the gene amplification and protein expression of FGFR1 were also reported...
August 31, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28965045/apoptosis-induced-by-caffeic-acid-phenethyl-ester-in-human-oral-cancer-cell-lines-involvement-of-puma-and-bax-activation
#16
Hyun-Ju Yu, Ji-Ae Shin, In-Hyoung Yang, Dong-Hoon Won, Chi Hyun Ahn, Hye-Jeong Kwon, Jeong-Sang Lee, Nam-Pyo Cho, Eun-Cheol Kim, Hye-Jung Yoon, Jae Il Lee, Seong-Doo Hong, Sung-Dae Cho
OBJECTIVE: Caffeic acid phenethyl ester (CAPE), a natural honeybee product exhibits a spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant and antitumor actions. The purpose of this research was to investigate the anticancer potential of CAPE and its molecular mechanism in human oral cancer cell lines (YD15, HSC-4 and HN22 cells). DESIGN: To determine the apoptotic activity of CAPE and identify its molecular targets, trypan blue exclusion assay, soft agar assay, Western blot analysis, DAPI staining, and live/dead assay were performed...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28960205/coordinated-repression-of-bim-and-puma-by-epstein-barr-virus-latent-genes-maintains-the-survival-of-burkitt-lymphoma-cells
#17
Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter, Rosemary J Tierney, Marco J Herold, Andrew I Bell, Andreas Strasser, Gemma L Kelly, Martin Rowe
While the association of Epstein-Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, the precise role of the virus in BL pathogenesis is not fully resolved. EBV can be lost spontaneously from some BL cell lines, and these EBV-loss lymphoma cells reportedly have a survival disadvantage. Here we have generated an extensive panel of EBV-loss clones from multiple BL backgrounds and examined their phenotype comparing them to their isogenic EBV-positive counterparts. We report that, while loss of EBV from BL cells is rare, it is consistently associated with an enhanced predisposition to undergo apoptosis and reduced tumorigenicity in vivo...
September 29, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28946550/hp1%C3%AE-is-highly-expressed-in-glioma-cells-and-facilitates-cell-proliferation-and-survival
#18
Xianliang Lai, Zhifeng Deng, Hua Guo, Xingen Zhu, Wei Tu
Epigenetic alteration plays critical roles in gliomagenesis by regulating gene expression through modifications of Histones and DNA. Trimethylation of H3K9, an essential repressed transcription mark, and one of its methyltransferase, SUV39H1, are implicated in glioma pathogenesis and progression. We find that the protein level of HP1α, a reader of H3K9me3 is elevated in GOS3 and 1321N1 glioma cell lines. H3K9me3 and SUV39H1 level are also upregulated. Depletion of HP1α and SUV39H1 weakens GOS3 and 1321N1 cell proliferation capacity and results in apoptosis of cells...
September 1, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28939557/a-chemical-modulator-of-p53-transactivation-that-acts-as-a-radioprotective-agonist
#19
Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi, Toshiya Inaba
Inhibiting p53-dependent apoptosis by inhibitors of p53 is an effective strategy for preventing radiation-induced damage in hematopoietic lineages, while p53 and p21 also play radioprotective roles in the gastrointestinal epithelium. We previously identified some zinc(II) chelators, including 8-quinolinol derivatives that suppress apoptosis in attempts to discover compounds that target the zinc-binding site in p53. We found that 5-chloro-8-quinolinol (5CHQ) has a unique p53-modulating activity that shifts its transactivation from proapoptotic to protective responses including enhancing p21 induction and suppressing PUMA induction...
September 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28931068/erk1-2-signalling-protects-against-apoptosis-following-endoplasmic-reticulum-stress-but-cannot-provide-long-term-protection-against-bax-bak-independent-cell-death
#20
Nicola J Darling, Kathryn Balmanno, Simon J Cook
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through the cell intrinsic, mitochondrial pathway. Indeed, cells that lack the key executioner proteins BAX and BAK are protected from ER stress-induced apoptosis. Here we show that chronic ER stress causes the progressive inhibition of the extracellular signal-regulated kinase (ERK1/2) signalling pathway...
2017: PloS One
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