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https://www.readbyqxmd.com/read/27900028/tumor-necrosis-factor-%C3%AE-induced-protein-8-like-1-promotes-apoptosis-by-regulating-b-cell-leukemia-lymphoma-2-family-proteins-in-raw264-7-cells
#1
Yinan Wang, Yao Liu, Chunfang Hu, Xiaoyan Ni, Xiaobo Huang
Although the newly identified protein tumor necrosis factor α-induced protein 8-like 1 (TNFAIP8L1), also known as TIPE1, has been reported to be able to induce apoptosis in human hepatocellular carcinoma cells, the involvement of TIPE1 in apoptosis remains to be elucidated. The present study investigated the pro-apoptotic effect of TIPE1 in an murine macrophage cell line, RAW264.7. The cell apoptosis rate was detected by flow cytometry. The results revealed that overexpressed TIPE1 could directly enhance the apoptosis and the cisplatin-induced cell death of RAW264...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898922/influence-of-pork-and-pork-by-products-on-macronutrient-and-energy-digestibility-and-palatability-in-large-exotic-felids
#2
C J Iske, C L Morris, K L Kappen
Two experiments were conducted to evaluate digestibility and palatability of a new commercial pork-based raw diet for zoo-managed felids. Currently 2 protein sources (beef or horse) comprise the majority of commercial raw meat diet formulations for exotic carnivores in zoological institutions. Pork-based diets have traditionally not been widely utilized and thus nutrient digestibility of pork has not been adequately evaluated in exotic carnivores. The objectives of this study were 1) to determine if a pork-based diet had similar apparent total tract macronutrient digestibility and fecal scores as standard zoo carnivore diets formulated with either horse or beef, in large exotic felids and 2) evaluate palatability of pork for use in zoos...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896021/lithocholic-acid-induces-endoplasmic-reticulum-stress-autophagy-and-mitochondrial-dysfunction-in-human-prostate-cancer-cells
#3
Ahmed A Gafar, Hossam M Draz, Alexander A Goldberg, Mohamed A Bashandy, Sayed Bakry, Mahmoud A Khalifa, Walid AbuShair, Vladimir I Titorenko, J Thomas Sanderson
Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and necrosis of androgen-dependent LNCaP and androgen-independent PC-3 human prostate cancer cells. In the present study, we investigated the roles of endoplasmic reticulum (ER) stress, autophagy and mitochondrial dysfunction in the toxicity of LCA in PC-3 and autophagy deficient, androgen-independent DU-145 cells...
2016: PeerJ
https://www.readbyqxmd.com/read/27889097/axonal-degeneration-is-regulated-by-a-transcriptional-program-that-coordinates-expression-of-pro-and-anti-degenerative-factors
#4
Maya Maor-Nof, Erez Romi, Hadas Sar Shalom, Valeria Ulisse, Calanit Raanan, Aviv Nof, Dena Leshkowitz, Roland Lang, Avraham Yaron
Developmental neuronal cell death and axonal elimination are controlled by transcriptional programs, of which their nature and the function of their components remain elusive. Here, we identified the dual specificity phosphatase Dusp16 as part of trophic deprivation-induced transcriptome in sensory neurons. Ablation of Dusp16 enhanced axonal degeneration in response to trophic withdrawal, suggesting that it has a protective function. Moreover, axonal skin innervation was severely reduced while neuronal elimination was increased in the Dusp16 knockout...
November 21, 2016: Neuron
https://www.readbyqxmd.com/read/27886165/induction-of-tumor-apoptosis-through-a-circular-rna-enhancing-foxo3-activity
#5
William W Du, Ling Fang, Weining Yang, Nan Wu, Faryal Mehwish Awan, Zhenguo Yang, Burton B Yang
Circular RNAs are a class of non-coding RNAs that are receiving extensive attention. Despite reports showing circular RNAs acting as microRNA sponges, the biological functions of circular RNAs remain largely unknown. We show that in patient tumor samples and in a panel of cancer cells, circ-Foxo3 was minimally expressed. Interestingly, during cancer cell apoptosis, the expression of circ-Foxo3 was found to be significantly increased. We found that silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts...
November 25, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27882064/the-evaluation-and-comparison-of-transcriptionally-targeted-noxa-and-puma-killer-genes-to-initiate-apoptosis-under-cancer-specific-promoter-cxcr1-in-hepatocarcinoma-gene-therapy
#6
Shahryar Khoshtinat Nikkhoi, Hedieh Heydarzadeh, Saeed Ranjbar, Fatemeh Salimi, Masoud Aghaeifard, Seyed Moayed Alavian, Azadeh Reshadmanesh
BACKGROUND: Cancerous cells proliferate as fast as possible without a proper surveillance system. This rapid cell division leads to enormous mutation rates, which help a tumor establish. OBJECTIVES: This study evaluated the potential of inducing apoptosis using Noxa and Puma in a hepatocarcinoma cell line. METHODS: The current study generated two recombinant lentiviruses, pLEX-GCN and pLEX-GCP, bearing Noxa and Puma, respectively. Transduction of both genes to hepatocarcinoma (HepG2) was verified using fluorescent microscopic analysis, western blotting, and quantitative real-time polymerase chain reaction (PCR)...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27878984/sulforaphane-induced-apoptosis-in-xuanwei-lung-adenocarcinoma-cell-line-xwlc-05
#7
Lan Zhou, Qian Yao, Yan Li, Yun-Chao Huang, Hua Jiang, Chuan-Qiong Wang, Lei Fan
BACKGROUND: Xuanwei district in Yunnan Province has the highest incidence of lung cancer in China, especially among non-smoking women. Cruciferous vegetables can reduce lung cancer risk by prompting a protective mechanism against respiratory tract inflammation caused by air pollution, and are rich in sulforaphane, which can induce changes in gene expression. We investigated the effect of sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line (XWCL-05) to explore the value of sulforaphane in lung cancer prevention and treatment...
November 23, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27865619/inhibition-on-the-growth-of-human-mda-mb-231-breast-cancer-cells-in-vitro-and-tumor-growth-in-a-mouse-xenograft-model-by-se-containing-polysaccharides-from-pyracantha-fortuneana
#8
Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yuan
Breast cancer is the second cause of cancer-related death among Women. Current therapies for breast cancer have adverse side-effects. Selenium (Se)-containing polysaccharides have multiple health benefits to humans. Pyracantha fortuneana (P. fortuneana) contains rich Se polysaccharides. We hypothesized that Se-containing polysaccharides from P. fortuneana possess anticancer activity on breast cancer via inhibiting growth and inducing apoptosis. This study aimed to assess the anticancer effect of Se-containing polysaccharides from P...
October 2, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27853625/targeting-of-slug-sensitizes-anaplastic-thyroid-carcinoma-sw1736-cells-to-doxorubicin-via-puma-upregulation
#9
Anbing Dong, Xuelong Jiao, Dong Chen, Fengyun Hao, Kejun Zhang
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers and often shows resistance to multimodal therapeutic approaches. It has been shown that the transcriptional repressor Slug inhibits the chemotherapeutic agent-induced apoptosis of cancer cells. We evaluated whether targeting of Slug could augment doxorubicin (DOX)-induced apoptosis of ATC cells. We also determined changes in PUMA (p53-upregulated modulator of apoptosis) expression levels to identify possible mechanisms of their combined actions...
2016: International Journal of Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27845389/bafilomycin-a1-induces-caspase-independent-cell-death-in-hepatocellular-carcinoma-cells-via-targeting-of-autophagy-and-mapk-pathways
#10
Yumei Yan, Ke Jiang, Peng Liu, Xianbin Zhang, Xin Dong, Jingchun Gao, Quentin Liu, Martin P Barr, Quan Zhang, Xiukun Hou, Songshu Meng, Peng Gong
Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations displays cytotoxicity in a variety of cancers. Here we show that BafA1 at nanomolar concentrations suppresses HCC cell growth in both 2 dimensional (2D) and 3D cultures. BafA1 induced cell cycle arrest in the G1 phase and triggered Cyclin D1 turnover in HCC cells in a dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) dependent manner...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27842902/pseudoaneurysm-after-transpedal-arterial-access-for-evaluation-and-treatment-of-peripheral-arterial-disease
#11
Apurva Patel, Roosha Parikh, Yili Huang, Michael Liou, Justin Ratcliffe, Olivier F Bertrand, Joseph Puma, Tak W Kwan
BACKGROUND: There has been an increasing use of transpedal arterial access (TPA) for evaluation and treatment of peripheral arterial disease (PAD) over a transfemoral approach (TFA). TPA, it is expected to be associated with better patient comfort, less recovery time and possibly less access site complications compared to standard TFA. Access site complications and pseudoaneurysm (PSA) associated with the TPA have not been previously reported. OBJECTIVE: Here we report a series of pedal artery PSA related to access site complicating TPA catheterization...
October 17, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27835761/correlation-between-circuital-current-cu-ii-reduction-and-cellular-electron-transfer-in-eab-isolated-from-cu-ii-reduced-biocathodes-of-microbial-fuel-cells
#12
Jingya Shen, Liping Huang, Peng Zhou, Xie Quan, Gianluca Li Puma
The performance of four indigenous electrochemically active bacteria (EAB) (Stenotrophomonas maltophilia JY1, Citrobacter sp. JY3, Pseudomonas aeruginosa JY5 and Stenotrophomonas sp. JY6) was evaluated for Cu(II) reduction on the cathodes of microbial fuel cells (MFCs). These EAB were isolated from well adapted mixed cultures on the MFC cathodes operated for Cu(II) reduction. The relationship between circuital current, Cu(II) reduction rate, and cellular electron transfer processes was investigated from a mechanistic point of view using X-ray photoelectron spectroscopy, scanning electronic microscopy coupled with energy dispersive X-ray spectrometry, linear sweep voltammetry and cyclic voltammetry...
November 5, 2016: Bioelectrochemistry
https://www.readbyqxmd.com/read/27834133/the-effects-of-colchicum-baytopiorum-on-regulatory-genes-of-apoptotic-and-autophagic-cell-death-in-hela-cells
#13
Özlem D Özsöylemez, Melek Öztürk, Nurhayat Sütlüpinar, Sera Kayacan, Matem Tunçdemir, Gül Özcan
BACKGROUND: The natural products have increasing important for the development of anticancer agents. Colchicum baytopiorum C.D.Brickell (C. baytopiorum), an endemic species for Turkey, contains colchicine and its derivatives. Stimulation of apoptotic and autophagy-mediated cell deaths are effective strategy for anticancer therapies. AIM: The aim of the study is to determine the role of the extract on both apoptotic and autophagic cell death in HeLa cell line. METHODS: The cell viability of C...
November 9, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27829997/propofol-inhibits-growth-and-invasion-of-pancreatic-cancer-cells-through-regulation-of-the-mir-21-slug-signaling-pathway
#14
Zimin Liu, Jian Zhang, Guangchen Hong, Jinping Quan, Lin Zhang, Meiqin Yu
AIM: Propofol, an intravenous anesthetic agent, has been found to inhibit invasion and growth of pancreatic cancer cells in vitro. However, the mechanisms underlying these tumor-promoting phenotypes are not known. The microRNA miR-21 has been reported to be overexpressed in pancreatic cancer, and overexpression of miR-21 confers a poor prognosis to patients with pancreatic cancer. Further studies have identified the E-cadherin transcription repressor Slug as a direct target of miR-21...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829861/itraq-based-proteomic-analysis-of-ginsenoside-f2-on-human-gastric-carcinoma-cells-sgc7901
#15
Qian Mao, Pin-Hu Zhang, Jie Yang, Jin-Di Xu, Ming Kong, Hong Shen, He Zhu, Min Bai, Li Zhou, Guang-Fu Li, Qiang Wang, Song-Lin Li
Ginsenoside F2 (F2), a protopanaxdiol type of saponin, was reported to inhibit human gastric cancer cells SGC7901. To better understand the molecular mechanisms of F2, an iTRAQ-based proteomics approach was applied to define protein expression profiles in SGC7901 cells in response to lower dose (20 μM) and shorter duration (12 hour) of F2 treatment, compared with previous study. 205 proteins were screened in terms of the change in their expression level which met our predefined criteria. Further bioinformatics and experiments demonstrated that F2 treatment downregulated PRR5 and RPS15 and upregulated RPL26, which are implicated in ribosomal protein-p53 signaling pathway...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27826017/igf-1-protects-against-a%C3%AE-25-35-induced-neuronal-cell-death-via-inhibition-of-puma-expression-and-bax-activation
#16
Xunyao Hou, Yan Jin, Jian Chen, Yan Hong, Dingzhen Luo, Qingqing Yin, Xueping Liu
No abstract text is available yet for this article.
November 4, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27825684/iterative-surgical-treatment-for-repeated-recurrences-after-complete-resection-of-thymic-tumors
#17
Alfonso Fiorelli, Antonio D'Andrilli, Camilla Vanni, Roberto Cascone, Marco Anile, Daniele Diso, Valentina Tassi, Jacopo Vannucci, Nicola Serra, Francesco Puma, Erino Angelo Rendina, Federico Venuta, Mario Santini
BACKGROUND: In this study, we evaluated if surgical treatment and iterative operations could confer a survival advantage for patients with recurrent or repeated recurrences of thymoma. METHODS: Between 1984 and 2014, 53 of 515 (10%) patients had recurrences after complete thymoma resection. Demographics, stage, treatment, and pathologic findings were statistically analyzed to identify survival prognostic factors. RESULTS: Thirty-eight of 53 (72%) patients underwent resection of recurrent thymoma; 32 (84%) underwent complete resection...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27817875/photoelectrochemical-cell-for-simultaneous-electricity-generation-and-heavy-metals-recovery-from-wastewater
#18
Dawei Wang, Yi Li, Gianluca Li Puma, Panagiotis Lianos, Chao Wang, Peifang Wang
The feasibility of simultaneous recovery of heavy metals from wastewater (e.g., acid mining and electroplating) and production of electricity is demonstrated in a novel photoelectrochemical cell (PEC). The photoanode of the cell bears a nanoparticulate titania (TiO2) film capped with the block copolymer [poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol)] hole scavenger, which consumed photogenerated holes, while the photogenerated electrons transferred to a copper cathode reducing dissolved metal ions and produced electricity...
February 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27812324/big-cat-coalitions-a-comparative-analysis-of-regional-brain-volumes-in-felidae
#19
Sharleen T Sakai, Bradley M Arsznov, Ani E Hristova, Elise J Yoon, Barbara L Lundrigan
Broad-based species comparisons across mammalian orders suggest a number of factors that might influence the evolution of large brains. However, the relationship between these factors and total and regional brain size remains unclear. This study investigated the relationship between relative brain size and regional brain volumes and sociality in 13 felid species in hopes of revealing relationships that are not detected in more inclusive comparative studies. In addition, a more detailed analysis was conducted of four focal species: lions (Panthera leo), leopards (Panthera pardus), cougars (Puma concolor), and cheetahs (Acinonyx jubatus)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27810593/novel-phenylenediamine-bridged-mixed-ligands-dimetallic-square-planner-pt-ii-complex-inhibits-mmps-expression-via-p53-and-caspase-dependent-signaling-and-suppress-cancer-metastasis-and-invasion
#20
Faiz-Ur Rahman, Amjad Ali, Inam Ullah Khan, Hong-Quan Duong, Rong Guo, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
Novel phenylenediamine bridged mixed ligands dimetallic square planner Pt(II) complex (L-Pt-Py) was synthesized from simple commercially available precursors in good yield and characterized by (1)H, (13)C, 2D NOESY NMR and high resolution mass spectrometry (HR-ESI-MS). The stability of L-Pt-Py was checked by (1)H NMR in mixed DMSO-d6/D2O solvents. L-Pt-Py showed considerable in vitro cytotoxicity in lung (A549), breast (MCF-7) and liver (HepG2) cancer cell lines and strong in vivo growth inhibition in Escherichia coli (E...
October 22, 2016: European Journal of Medicinal Chemistry
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