Eman Mansour, Ahmed A Abd-Rabou, Mohamed A El-Atawy, Hoda A Ahmed, Ahmed F El-Farargy, Heba K Abd El-Mawgoud
Breast cancer is a common public health disease causing mortality worldwide. Thus, providing novel chemotherapies that tackle breast cancer is of great interest. In this investigation, novel pyrido[2,3-d]pyrimidine derivatives 3,4,(6a-c),(8a,b),9-20 were synthesized and characterized using a variety of spectrum analyses. The geometric and thermal parameters of the novel thiouracil derivatives 3,4,6a,(8a,b),11,12,17,18, 19 were measured using density functional theory (DFT) via DFT/B3LYP/6-31 + G(d,p) basis set...
March 26, 2024: Bioorganic Chemistry