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https://www.readbyqxmd.com/read/28081302/education-and-support-needs-in-patients-with-head-and-neck-cancer-a-multi-institutional-survey
#1
Joe Jabbour, Chris Milross, Puma Sundaresan, Ardalan Ebrahimi, Heather L Shepherd, Haryana M Dhillon, Gary Morgan, Bruce Ashford, Muzib Abdul-Razak, Eva Wong, Michael Veness, Carsten E Palme, Cate Froggatt, Ruben Cohen, Rafael Ekmejian, Jessica Tay, David Roshan, Jonathan R Clark
BACKGROUND: Head and neck cancer (HNC) encompasses a diverse group of tumors, and thus providing appropriate and tailored information to patients before, during, and after treatment is a challenge. The objective of the current study was to characterize the experience and unmet needs of patients with HNC with regard to information and support provision. METHODS: A 28-question, cross-sectional survey was completed by patients treated for HNC at 1 of 4 institutions in New South Wales, Australia (Chris O'Brien Lifehouse and Liverpool, Westmead, and Wollongong hospitals)...
January 12, 2017: Cancer
https://www.readbyqxmd.com/read/28080904/photoreceptor-degeneration-in-a-mountain-lion-cub-puma-concolor
#2
Andrew R DiSalvo, Christopher M Reilly, K Tomo Wiggans, Leslie W Woods, Ray F Wack, Deana L Clifford
An orphaned 4-mo-old female mountain lion cub ( Puma concolor ) was captured along the coastline in Montaña de Oro State Park in Los Osos, California, USA. Following suspicion that the cub was visually impaired, ophthalmic examination revealed diffuse bilateral retinal atrophy. Due to a poor prognosis, humane euthanasia was elected. Necropsy and histopathological findings were consistent with photoreceptor degeneration. Based on the cub's signalment, history, and histopathology, a genetic or nutritional etiology was suspected, with the former etiology more strongly supported...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28073943/kdm4b-jmjd2b-is-a-p53-target-gene-that-modulates-the-amplitude-of-p53-response-after-dna-damage
#3
Laura Castellini, Eui Jung Moon, Olga V Razorenova, Adam J Krieg, Rie von Eyben, Amato J Giaccia
The p53 tumor suppressor protein plays a critical role in orchestrating the genomic response to various stress signals by acting as a master transcriptional regulator. Differential gene activity is controlled by transcription factors but also dependent on the underlying chromatin structure, especially on covalent histone modifications. After screening different histone lysine methyltransferases and demethylases, we identified JMJD2B/KDM4B as a p53-inducible gene in response to DNA damage. p53 directly regulates JMJD2B gene expression by binding to a canonical p53-consensus motif in the JMJD2B promoter...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28066614/the-role-of-bronchoscopy-in-the-diagnosis-of-early-lung-cancer-a-review
#4
REVIEW
Marco Andolfi, Rossella Potenza, Rosanna Capozzi, Valeria Liparulo, Francesco Puma, Kazuhiro Yasufuku
Lung cancer is the leading cause of cancer-related deaths worldwide with an overall 5-year survival rate of 17% after diagnoses. Indeed many patients tend to have a very poor prognosis, due to being diagnosed at an advanced stage. Conversely patients who are diagnosed at an early stage have a 5-year survival >70%, indicating that early detection of lung cancer is crucial to improve survival. Although flexible bronchoscopy is a relatively non-invasive procedure for patients suspected of having lung cancer, only 29% of carcinoma in situ (CIS) and 69% of microinvasive tumors were detectable using white light bronchoscopy (WLB) alone...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28062877/-right-hepatectomy-in-block-with-hiliar-extra-hepatic-bile-duct-for-gallbladder-cancer-clinical-case
#5
Claudio Mengoa Quintanilla, Giovanni De la Cruz Robles, Sergio Puma Condori, Carol Durand Mendoza
Gallbladder cancer is the most common malignancy of the biliary tract. Usually seen in advanced stages. There are still many controversies about the type of curative surgical treatment for each stage of the disease. The only chance of long term survival for patients with advanced tumors is aggressive, large surgeries that implies multiorgan resection.We report the case of a patient with gallbladder cancer with jaundice at diagnosis, who underwent extended hepatectomy (segment IV B, segment I and extra hepatic hilar bile duct included)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28048945/organotypic-spheroid-culture-to-mimic-radiation-induced-salivary-hypofunction
#6
H S Shin, H Y An, J S Choi, H J Kim, J Y Lim
Radiation treatment often leads to irreversible damage to normal salivary glands (SGs) because of their proximity to head and neck cancers. Optimization of the in vitro model of irradiation (IR)-induced SG damage is warranted to investigate pathophysiology and monitor treatment outcome. Here, we present an organotypic spheroid culture model to investigate the impact of IR on SGs and the mechanisms underlying IR-induced structural and functional changes. Human parotid epithelial cells were obtained from human parotid glands and plated on either plastic plates or Matrigel...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/28024874/dental-and-temporomandibular-joint-pathology-of-the-california-mountain-lion-puma-concolor-couguar
#7
A Aghashani, A S Kim, P H Kass, F J M Verstraete
Skulls from 91 California mountain lions (Puma concolor couguar) were examined macroscopically and radiographically. The majority of the skulls were from young adult animals (57.1%). The skull specimens were from 42 male (46.1%) and 34 female (37.4%) animals, while the gender was unknown for the remainder. The majority (94.5%) of teeth were present for examination. Only 11 teeth were identified as absent congenitally; five of these teeth were maxillary first molar teeth and three were maxillary second premolar teeth...
December 23, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28012060/adipocyte-microenvironment-promotes-bclxl-expression-and-confers-chemoresistance-in-ovarian-cancer-cells
#8
Carlos Cardenas, Michele K Montagna, Mary Pitruzzello, Eydis Lima, Gil Mor, Ayesha B Alvero
Resistance to mitochondria-initiated apoptosis is a hallmark of chemoresistant cancer stem cells including CD44+/MyD88+ epithelial ovarian cancer (EOC) stem cells. This is controlled by members of the Bcl2 family of proteins, which function as rheostats of mitochondrial stability. We observed a differential expression profile of Bcl2 family members comparing the chemoresistant EOC stem cells and the chemosensitive CD44-/MyD88- EOC cells. Chemoresistant EOC stem cells surprisingly express higher levels of the pro-apoptotic members Bak and Bax compared to the chemosensitive EOC cells...
December 23, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28009301/tight-sequestration-of-bh3-proteins-by-bcl-xl-at-subcellular-membranes-contributes-to-apoptotic-resistance
#9
Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A Sarosiek, Florian J Bock, Frédérique Braun, Anthony Letai, Stephen W G Tait, Fabien Gautier, Philippe P Juin
Anti-apoptotic BCL-2 family members bind to BH3-only proteins and multidomain BAX/BAK to preserve mitochondrial integrity and maintain survival. Whereas inhibition of these interactions is the biological basis of BH3-mimetic anti-cancer therapy, the actual response of membrane-bound protein complexes to these compounds is currently ill-defined. Here, we find that treatment with BH3 mimetics targeting BCL-xL spares subsets of cells with the highest levels of this protein. In intact cells, sequestration of some pro-apoptotic activators (including PUMA and BIM) by full-length BCL-xL is much more resistant to derepression than previously described in cell-free systems...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/28008961/human-expansion-precipitates-niche-expansion-for-an-opportunistic-apex-predator-puma-concolor
#10
Wynne E Moss, Mathew W Alldredge, Kenneth A Logan, Jonathan N Pauli
There is growing recognition that developed landscapes are important systems in which to promote ecological complexity and conservation. Yet, little is known about processes regulating these novel ecosystems, or behaviours employed by species adapting to them. We evaluated the isotopic niche of an apex carnivore, the cougar (Puma concolor), over broad spatiotemporal scales and in a region characterized by rapid landscape change. We detected a shift in resource use, from near complete specialization on native herbivores in wildlands to greater use of exotic and invasive species by cougars in contemporary urban interfaces...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28008149/idelalisib-induces-puma-dependent-apoptosis-in-colon-cancer-cells
#11
Shida Yang, Zhiyong Zhu, Xiaobing Zhang, Ning Zhang, Zhicheng Yao
Idelalisib, a PI3K inhibitor, specifically targeting p110δ, has been approved for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma. However, the mechanisms of action of idelalisib in colon cancer cells are not well understood. We investigated how idelalisib suppresses colon cancer cells growth and potentiates effects of other chemotherapeutic drugs. In this study, we found that idelalisib treatment induces PUMA in colon cancer cells irrespective of p53 status through the p65 pathway following AKT inhibition and glycogen synthase kinase 3β (GSK3β) activation...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28003486/feline-immunodeficiency-virus-cross-species-transmission-implications-for-emergence-of-new-lentiviral-infections
#12
Justin Lee, Jennifer L Malmberg, Britta A Wood, Sahaja Hladky, Ryan Troyer, Melody Roelke, Mark Cunningham, Roy McBride, Winston Vickers, Walter Boyce, Erin Boydston, Laurel Serieys, Seth Riley, Kevin Crooks, Sue VandeWoude
: Owing to a complex history of host-parasite coevolution, lentiviruses exhibit a high degree of species specificity. Given the well-documented viral archeology of HIV emergence following human exposures to SIV, understanding processes that promote successful cross-species lentiviral transmissions is highly relevant. We have previously reported natural cross-species transmission of a subtype of feline immunodeficiency virus, puma lentivirus A (PLVA), between bobcats (Lynx rufus) and mountain lions (Puma concolor) in a small number of animals in California and Florida...
December 21, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27994446/exacerbations-and-health-care-resource-utilization-in-patients-with-airflow-limitation-diseases-attending-a-primary-care-setting-the-puma-study
#13
Maria Montes de Oca, Carlos Aguirre, Maria Victorina Lopez Varela, Maria E Laucho-Contreras, Alejandro Casas, Filip Surmont
BACKGROUND: COPD, asthma, and asthma-COPD overlap increase health care resource consumption, predominantly because of hospitalization for exacerbations and also increased visits to general practitioners (GPs) or specialists. Little information is available regarding this in the primary care setting. OBJECTIVES: To describe the prevalence and number of GP and specialist visits for any cause or due to exacerbations in patients with COPD, asthma, and asthma-COPD overlap...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27980105/the-mtorc1-2-inhibitor-azd8055-strengthens-the-efficiency-of-the-mek-inhibitor-trametinib-to-reduce-the-mcl-1-bim-and-puma-ratio-and-to-sensitize-ovarian-carcinoma-cells-to-abt-737
#14
Cécile Pétigny-Lechartier, Charlène Duboc, Abdelghani Jebahi, Marie-Hélène Louis, Edwige Abeilard, Christophe Denoyelle, Pascal Gauduchon, Laurent Poulain, Marie Villedieu
The identification of novel therapeutic strategies is an important urgent requirement for the clinical management of ovarian cancer, which remains the leading cause of death from gynecologic cancer. Several studies have shown that the antiapoptotic proteins Bcl-xL and Mcl-1, as well as the proapoptotic protein Bim, are key elements to be modulated to kill ovarian cancer cells. Pharmacologic inhibition of Bcl-xL is possible by using BH3-mimetic molecules like ABT-737. However, inhibition of Mcl-1 and/or promotion of its BH3-only partners (including Bim, Puma, and Noxa) remains a challenge that may be achieved by modulating the signaling pathways upstream...
January 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27970184/tct-794-expanding-the-paradigm-of-treatment-in-infrapopliteal-arterial-occlusive-disease-quality-of-life-benefits-of-transpedal-access-single-tibial-vessel-intervention
#15
Apurva Patel, Roosha Parikh, Samuel Kolman, Jeffrey Ma, Justin Ratcliffe, Joseph Puma, Tak Kwan
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970181/tct-791-a-single-center-experience-of-transpedal-vs-transfemoral-approach-for-infrainguinal-endovasuclar-interventions
#16
Sooraj Shah, Joseph Puma, Olivier Bertrand, Tak Kwan
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970175/tct-787-the-evolution-of-therapy-for-infrainguinal-arterial-occlusive-disease-improvement-in-quality-of-life-with-endovascular-interventions-via-transpedal-access
#17
Apurva Patel, Roosha Parikh, Jeffrey Ma, Samuel Kolman, Justin Ratcliffe, Joseph Puma, Tak Kwan
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27956034/classification-of-patients-with-chronic-obstructive-pulmonary-disease-according-to-the-latin-american-thoracic-association-alat-staging-systems-and-the-global-initiative-for-chronic-obstructive-pulmonary-disease-gold
#18
Maria Montes de Oca, María Victorina López Varela, María Eugenia Laucho-Contreras, Alejandro Casas, Eduardo Schiavi, Alejandra Rey, Alejandra Silva
INTRODUCTION: Several classification systems use different criteria when assessing COPD stages. The objective of this study was to compare the prevalence and distribution of COPD stagesusing Global initiative for chronic Obstructive Lung Disease (GOLD) recommendationsand Latin American Thoracic Association (ALAT) guidelinesin a primary-care population. METHODS: Subjects attending routine primary care visits, ≥40 years of age, current or former smokers or exposed to biomass, completed a questionnaire and performed spirometry...
December 9, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27940575/mda-7-il-24-mediates-cancer-cell-specific-death-via-regulation-of-mir-221-and-the-beclin-1-axis
#19
Anjan K Pradhan, Sarmistha Talukdar, Praveen Bhoopathi, Xue-Ning Shen, Luni Emdad, Swadesh K Das, Devanand Sarkar, Paul B Fisher
Melanoma differentiation associated gene-7/Interleukin-24 (mda-7/IL-24) displays broad-spectrum anti-cancer activity in vitro, in vivo in preclinical animal models, and in a phase I/II clinical trial in patients with advanced cancers without harming normal cells or tissues. Here we demonstrate that mda-7/IL-24 regulates a specific subset of miRNAs, including cancer-associated miR-221. Either ectopic expression of mda-7/IL-24 or treatment with recombinant His-MDA-7 protein resulted in downregulation of miR-221 and upregulation of p27 and PUMA in a panel of cancer cells, culminating in cell death...
December 9, 2016: Cancer Research
https://www.readbyqxmd.com/read/27927748/axl-receptor-signalling-suppresses-p53-in-melanoma-through-stabilization-of-the-mdmx-mdm2-complex
#20
Anna de Polo, Zhongling Luo, Casimiro Gerarduzzi, Xiang Chen, John B Little, Zhi-Min Yuan
Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX-MDM2 heterocomplex and the activity of p53 in melanoma cells. Our data demonstrated that AXL overexpression or activation through growth arrest-specific 6 (Gas6) ligand stimulation increases MDMX and MDM2 protein levels and decreases p53 activity...
November 9, 2016: Journal of Molecular Cell Biology
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