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Contrast enhanced ultrasound testes

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https://www.readbyqxmd.com/read/28332442/ultrasound-imaging-in-the-diagnosis-of-large-vessel-vasculitis
#1
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Nowadays noninvasive vascular imaging has an important role in the diagnostic work-up of the large vessel vasculitides (LVV), most importantly giant cell arteritis (GCA) and Takayasu arteritis. Among the imaging modalities available, ultrasound (US) has several important advantages, including low costs, rapid and repetitive availability without exposure to radiation, and high spatial resolution for assessment of large and medium-sized arteries. Therefore, US can be regarded the first line imaging method in suspected LVV...
March 23, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28288892/mr-image-guided-delivery-of-cisplatin-loaded-brain-penetrating-nanoparticles-to-invasive-glioma-with-focused-ultrasound
#2
Kelsie F Timbie, Umara Afzal, Abhijit Date, Clark Zhang, Ji Song, G Wilson Miller, Jung Soo Suk, Justin Hanes, Richard J Price
Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a "blood-tumor barrier" (BTB), which inhibits drug delivery and distribution. Meanwhile, beyond the contrast MRI-enhancing edge of the tumor, invasive cancer cells are protected by the intact blood-brain barrier (BBB). Here, we tested whether brain-penetrating nanoparticles (BPN) that possess dense surface coatings of polyethylene glycol (PEG) and are loaded with cisplatin (CDDP) could be delivered across both the blood-tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this treatment could control glioma growth and invasiveness...
March 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28280455/increasing-of-blood-brain-tumor-barrier-permeability-through-transcellular-and-paracellular-pathways-by-microbubble-enhanced-diagnostic-ultrasound-in-a-c6-glioma-model
#3
Jinlong Zhang, Heng Liu, Xuesong Du, Yu Guo, Xiao Chen, Shunan Wang, Jingqin Fang, Peng Cao, Bo Zhang, Zheng Liu, Weiguo Zhang
Most of the anticancer agents cannot be efficiently delivered into the brain tumor because of the existence of blood-brain tumor barrier (BTB). The objective of this study was to explore the effect of microbubble-enhanced diagnostic ultrasound (MEUS) on the BTB permeability and the possible mechanism. Glioma-bearing rats were randomized into three groups as follows: the microbubble-enhanced continued diagnostic ultrasound (MECUS) group; the microbubble-enhanced intermittent diagnostic ultrasound (MEIUS) group and the control group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28268996/effects-of-phase-aberration-correction-methods-on-the-minimum-variance-beamformer
#4
Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello
The minimum variance (MV) beamformer is a method that has the potential to enhance the resolution and contrast of ultrasound images. However, it suffers from sensitivity to speed of sound errors and aberration. Although there have been several studies on the application of phase aberration correction (PAC) methods to conventional delay-and-sum (DAS) beamforming, the benefits of PAC methods in mitigating the effects of phase aberration in MV beamformed images are not well understood. A study of this type would be helpful in designing a robust beamformer based on PAC knowledge present in the literature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28243120/correlations-of-microvascular-blood-flow-of-contrast-enhanced-ultrasound-and-hgf-c-met-signaling-pathway-with-clinicopathological-features-and-prognosis-of-patients-with-hepatocellular-carcinoma
#5
Peng-Hui Zhuang, Lei Xu, Lu Gao, Wei Lu, Li-Tao Ruan, Jin Yang
The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathologically diagnosed as primary HCC were selected. All HCC patients underwent CEUS examination before operation. HCC tissues and adjacent normal tissue specimens were obtained to detect the protein rates of HGF and c-Met expressions by immunohistochemistry...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28240217/quantitative-ultrasound-molecular-imaging-by-modeling-the-binding-kinetics-of-targeted-contrast-agent
#6
Simona Turco, Isabelle Tardy, Peter Frinking, Hessel Wijkstra, Massimo Mischi
Ultrasound molecular imaging (USMI) is an emerging technique to monitor diseases at the molecular level by the use of novel targeted ultrasound contrast agents (tUCA). These consist of microbubbles functionalized with targeting ligands with high-affinity for molecular markers of specific disease processes, such as cancer-related angiogenesis. Among the molecular markers of angiogenesis, the vascular endothelial growth factor receptor 2 (VEGFR2) is recognized to play a major role. In response, the clinical-grade tUCA BR55 was recently developed, consisting of VEGFR2-targeting microbubbles which can flow through the entire circulation and accumulate where VEGFR2 is over-expressed, thus causing selective enhancement in areas of active angiogenesis...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28230035/a-meta-analysis-of-contrast-enhanced-ultrasound-for-small-hepatocellular-carcinoma-diagnosis
#7
Huadong Deng, Hongwei Shi, Jianming Lei, Yan Hu, Gang Li, Chaojun Wang
OBJECTIVE: To discuss the efficacy of contrast-enhanced ultrasound (CEUS) for diagnosis of small hepatocellular carcinoma (HCC) by pooling the open published data. METHODS: A comprehensive publication electronic search was performed by reviewers in the databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure. The open published studies about CEUS for small HCC diagnosis were collected. The sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) were pooled by stata 12...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28227206/effects-of-phase-aberration-correction-methods-on-the-minimum-variance-beamformer
#8
Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello, Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello, Gustavo R Chau, Roberto J Lavarello
The minimum variance (MV) beamformer is a method that has the potential to enhance the resolution and contrast of ultrasound images. However, it suffers from sensitivity to speed of sound errors and aberration. Although there have been several studies on the application of phase aberration correction (PAC) methods to conventional delay-and-sum (DAS) beamforming, the benefits of PAC methods in mitigating the effects of phase aberration in MV beamformed images are not well understood. A study of this type would be helpful in designing a robust beamformer based on PAC knowledge present in the literature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28193267/abdominal-ultrasound-scanning-versus-non-contrast-computed-tomography-as-screening-method-for-abdominal-aortic-aneurysm-a-validation-study-from-the-randomized-dancavas-study
#9
Mads Liisberg, Axel C Diederichsen, Jes S Lindholt
BACKGROUND: Validating non-contrast-enhanced computed tomography (nCT) compared to ultrasound sonography (US) as screening method for abdominal aortic aneurysm (AAA) screening. METHODS: Consecutively attending men (n = 566) from the pilot study of the randomized Danish CardioVascular Screening trial (DANCAVAS trial), underwent nCT and US examination. Diameters were measured in outer-to-outer fashion. Sensitivity and specificity were done testing each modality against each other as reference standard...
February 14, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28186627/value-of-three-section-contrast-enhanced-transrectal-ultrasonography-in-the-detection-of-prostate-cancer
#10
Ting-Yue Qi, Hong-Guang Sun, Nian-Fen Li, Hao Feng, Yong-Ling Ding, Xiao-Xiang Wang
BACKGROUND: To assess the efficacy of three-section contrast-enhanced transrectal ultrasonography (CETRUS) in prostate cancer (PCa) detection. METHODS: A total of 169 consecutive patients with either PSA level ≥ 4 ng/ml or abnormal digital rectal examination findings were prospectively enrolled in this single center study. All patients underwent baseline transrectal ultrasonography (TRUS) and three-section CETRUS by one investigator blinded to any clinical data before TRUS-guided transperineal biopsy...
February 10, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28144721/focal-fat-deposition-in-the-liver-diagnostic-challenges-on-imaging
#11
REVIEW
Jong Keon Jang, Hyun-Jung Jang, Jin Sil Kim, Tae Kyoung Kim
While focal fat deposition in the liver mostly occurs in typical locations related to non-portal venous supply, unusual patterns of focal fat deposition, including multi-nodular, mass-like, and perivascular patterns, mimic malignancies and cause diagnostic challenges. Patients with unusual focal fat deposition often have potential underlying etiologies such as diabetes, alcohol abuse, metabolic disease, or various medications/chemotherapy. Some cases can be explained by non-portal venous supply or ischemia...
February 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28144402/impact-of-contrast-enhanced-ultrasound-in-patients-with-renal-function-impairment
#12
Rossano Girometti, Tiziano Stocca, Elena Serena, Antonio Granata, Michele Bertolotto
AIM: To investigate the role of contrast enhanced ultrasound (CEUS) in evaluating patients with renal function impairment (RFI) showing: (1) acute renal failure (ARF) of suspicious vascular origin; or (2) suspicious renal lesions. METHODS: We retrospectively evaluated patients addressed to CEUS over an eight years period to rule-out vascular causes of ARF (first group of 50 subjects) or assess previously found suspicious renal lesions (second group of 41 subjects with acute or chronic RFI)...
January 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28114062/delay-and-standard-deviation-beamforming-to-enhance-specular-reflections-in-ultrasound-imaging
#13
Raja Sekhar Bandaru, Anders Sornes, Jeroen Hermans, Eigil Samset, Jan D'hooge
Although interventional devices such as needles, guide wires and catheters are best visualized by X-ray, real-time volumetric echography could offer an attractive alternative as it avoids ionizing radiation; it provides good soft tissue contrast and it is mobile and relatively cheap. Unfortunately, as echography is traditionally used to image soft tissue and blood flow, the appearance of interventional devices in conventional ultrasound images remains relatively poor which is a major obstacle towards ultrasound-guided interventions...
September 27, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28113929/entropy-of-ultrasound-contrast-agent-velocity-fields-for-angiogenesis-imaging-in-prostate-cancer
#14
Ruud van Sloun, Libertario Demi, Arnoud Postema, Jean de la Rosette, Hessel Wijkstra, Massimo Mischi
Prostate cancer care can benefit from accurate and cost-efficient imaging modalities that are able to reveal prognostic indicators for cancer. Angiogenesis is known to play a central role in the growth of tumors towards a metastatic or a lethal phenotype.With the aim of localizing angiogenic activity in a noninvasive manner, Dynamic Contrast Enhanced Ultrasound (DCEUS) has been widely used. Usually, the passage of ultrasound contrast agents thought the organ of interest is analyzed for the assessment of tissue perfusion...
November 16, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113620/fast-vascular-ultrasound-imaging-with-enhanced-spatial-resolution-and-background-rejection
#15
Avinoam Bar-Zion, Charles Tremblay-Darveau, Oren Solomon, Dan Adam, Yonina Eldar
Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However, these techniques are currently limited by low temporal resolution and long acquisition times. Super-resolution optical fluctuation imaging (SOFI) is a fluorescence microscopy technique enabling sub-diffraction limit imaging with high temporal resolution by calculating high order statistics of the fluctuating optical signal...
August 15, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28102955/compound-speckle-model-detects-anti-angiogenic-tumor-response-in-preclinical-nonlinear-contrast-enhanced-ultrasonography
#16
Matthew R Lowerison, Justin J Tse, M Nicole Hague, Ann F Chambers, David W Holdsworth, James C Lacefield
PURPOSE: This paper proposes a method for analyzing the first-order speckle statistics of nonlinear contrast-enhanced ultrasound images from tumors. METHODS: Contrast signal intensity is modeled as a compound distribution of exponential probability density functions with a gamma weighting function. The gamma probability weighting function serves as an approximation for log-normally distributed flow velocities in a vascular network. The model was applied to sub-harmonic bolus-injection images acquired from a mouse breast cancer xenograft model treated with murine version bevacizumab...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28098400/role-of-contrast-enhanced-sonography-in-the-evaluation-of-axillary-lymph-nodes-in-breast-carcinoma-a-monocentric-study
#17
Giacomo Agliata, Gianluca Valeri, Giulio Argalia, Elisa Tarabelli, Gian Marco Giuseppetti
OBJECTIVES: To evaluate the diagnostic performance of contrast-enhanced sonography for characterization of the lymph node status (metastatic or not) in patients with breast carcinomas by comparison with sentinel lymph node biopsy. METHODS: From January to August 2015, 50 female patients with a histologic diagnosis of invasive breast carcinoma were prospectively examined by ipsilateral axillary contrast-enhanced sonography. The test was performed by a single radiologist using an ultrasound system with a broadband 8-12-MHz, 38-mm high-resolution linear transducer...
January 18, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28067009/one-step-3d-tv-hysterosalpingo-foam-sonography-3d-tv-hyfosy-confirmation-test-for-essure%C3%A2-follow-up-a-multicenter-study
#18
Brunella Zizolfi, Lucia Lazzeri, Mario Franchini, Attilio Di Spiezio Sardo, Carmine Nappi, Emilio Piccione, Caterina Exacoustos
OBJECTIVE: To evaluate the feasibility and accuracy of a three-dimensional-transvaginal-hysterosalpingo-contrast-sonography using the new dedicated contrast-enhanced gel foam (3D-TV-HyFoSy) to assess the position of the tubal sterilization Essure® devices and consequent tubal occlusion in patients who underwent Essure® hysteroscopic tubal sterilization. METHODS: This multicenter study was prospectively conducted from June 2012 to July 2014 in four italian centers and included 50 women who underwent hysteroscopic Essure® microinsert placement, for a total of 95 tubes...
January 9, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28063077/automatic-gallbladder-and-gallstone-regions-segmentation-in-ultrasound-image
#19
Jing Lian, Yide Ma, Yurun Ma, Bin Shi, Jizhao Liu, Zhen Yang, Yanan Guo
PURPOSE: As gallbladder diseases including gallstone and cholecystitis are mainly diagnosed by using ultra-sonographic examinations, we propose a novel method to segment the gallbladder and gallstones in ultrasound images. METHODS: The method is divided into five steps. Firstly, a modified Otsu algorithm is combined with the anisotropic diffusion to reduce speckle noise and enhance image contrast. The Otsu algorithm separates distinctly the weak edge regions from the central region of the gallbladder...
January 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28052301/c-arm-cone-beam-computed-tomography-guidance-for-radiofrequency-ablation-in-hepatocellular-carcinoma
#20
Keizo Kato, Hiroshi Abe, Makiko Ika, Takeshi Yonezawa, Yoshiyuki Sato, Noriko Hanawa, Shohei Shimizu, Shinji Endo, Ryota Matsuo, Akihito Tsubota
OBJECTIVE: To assess the usefulness of C-arm cone beam computed tomography (CBCT) combined with ultrasound for the treatment of hepatocellular carcinoma (HCC) by radiofrequency ablation (RFA). METHODS: Patients underwent RFA following transcatheter arterial chemoembolization (TACE) or RFA alone under ultrasound or CBCT guidance combined with ultrasound-based techniques. They were divided into 2 groups based on the use (C group) and nonuse (NC group) of CBCT guidance...
2017: Oncology
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