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Contrast enhanced ultrasound testes

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https://www.readbyqxmd.com/read/28522149/measuring-absolute-blood-perfusion-in-mice-using-dynamic-contrast-enhanced-ultrasound
#1
Abbas Shirinifard, Suresh Thiagarajan, Melissa D Johnson, Christopher Calabrese, András Sablauer
We investigated the feasibility of estimating absolute tissue blood perfusion using dynamic contrast-enhanced ultrasound (CEUS) imaging in mice. We developed a novel method of microbubble administration and a model-free approach to estimate absolute kidney perfusion, and explored the kidney as a reference organ to estimate absolute perfusion of a neuroblastoma tumor. We performed CEUS on the kidneys of CD1 nude mice using the VisualSonics VEVO 2100 imaging system. We estimated individual kidney blood perfusion using the burst-replenishment (BR) technique...
May 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28471148/clinical-imaging-in-patients-experiencing-chest-pain
#2
Angelo Silverio, Rodolfo Citro
Non-invasive imaging modalities integrate the clinical and laboratory diagnostic work-up of patients admitted in emergency department for chest pain. Transthoracic echocardiography is the first-line imaging tool because it is rapidly and widely available, bedside feasible and cost-effective. Even when a comprensive exam is not feasible, a fast focused ultrasound exam should be performed. Contrast enhanced computed tomography is an easily accessible tool with specific application in patients suspected for pulmonary embolism (PE) and acute coronary syndrome (ACS) according to the pre-test risk assessment and to the clinical status...
May 3, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28425493/characterization-of-different-microbubbles-in-assisting-focused-ultrasound-induced-blood-brain-barrier-opening
#3
Sheng-Kai Wu, Po-Chun Chu, Wen-Yen Chai, Shih-Tsung Kang, Chih-Hung Tsai, Ching-Hsiang Fan, Chih-Kuang Yeh, Hao-Li Liu
Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). However, limited understanding is available regarding the effect of different microbubbles to induce BBB opening. The aim of this study is to characterize different MBs on their effect in FUS-induced BBB opening. Three MBs, SonoVue, Definity, and USphere, were tested, with 0.4-MHz FUS exposure at 0.62-1.38 of mechanical index (MI) on rats...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385584/a-study-of-the-clinical-utility-of-a-20-minute-secretin-stimulated-endoscopic-pancreas-function-test-and-performance-according-to-clinical-variables
#4
Luis F Lara, Morihito Takita, James S Burdick, Daniel C DeMarco, Ronnie R Pimentel, Tolga Erim, Marlon F Levy
BACKGROUND AND AIMS: Direct pancreas juice testing of bicarbonate, lipase, or trypsin after stimulation by secretin or cholecystokinin is used to determine exocrine function, a surrogate for diagnosing chronic pancreatitis (CP). Endoscopic pancreas function tests (ePFTs), where a peak bicarbonate concentration (PBC) ≥80 mEq/L in pancreas juice is considered normal, are now used more frequently. In this ePFT, aspirates start 35 minutes after secretin administration because pancreas output peaks 30 minutes after secretagogue administration...
April 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28372458/hepatocellular-carcinoma-presenting-with-budd-chiari-syndrome-right-atrial-thrombus-and-pulmonary-emboli
#5
Luís C Lourenço, David V Horta, Sara F Alberto, Jorge Reis
A 47-year-old patient presented with a two-week history of right upper quadrant pain, abdominal distention and new onset of shortness of breath. He had a history of intravenous drug abuse, no alcohol consumption and denied any known liver disease. On physical examination, he was tachypneic and had dullness in the flanks. His blood analysis at admission was as follows: hemoglobin, 12.9 g/dL; leukocyte count, 6,800/uL; platelet count, 63,000/uL; INR, 2.1; serum creatinine, 1.27 mg/dL; liver biochemistry tests were notable for marginal derangement, HBsAg was negative, anti-HCV was positive, HCV RNA was 367,498 IU/ml and alpha-fetoprotein was 992 mg/dL...
April 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28363948/false-negative-contrast-enhanced-spectral-mammography-use-of-more-than-one-imaging-modality-and-application-of-the-triple-test-avoids-misdiagnosis
#6
Donna Taylor, Susan O'Hanlon, Bruce Latham
A 50-year-old woman presented with chest tenderness. On examination, both breasts were lumpy. Bilateral mammography showed heterogeneously dense parenchyma, with possible stromal distortion laterally on the right at the 0900 position. On ultrasound (US), a corresponding 13×9×10 mm irregular hypoechoic mass with internal vascularity was noted and both breasts had a complex heterogeneous fibroglandular background pattern. US-guided core biopsy with marker clip insertion was performed with the diagnosis of a grade 2 invasive ductal carcinoma (IDC)...
March 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28363670/using-the-analytic-hierarchy-process-for-prioritizing-imaging-tests-in-diagnosis-of-suspected-appendicitis
#7
Maria Agapova, Brian W Bresnahan, Ken F Linnau, Louis P Garrison, Mitchell Higashi, Larry Kessler, Beth Devine
RATIONALE AND OBJECTIVES: In clinical guideline or criteria development processes, such as those used in developing American College of Radiology Appropriateness Criteria (ACR AC), experts subjectively evaluate benefits and risks associated with imaging tests and make complex decisions about imaging recommendations. The analytic hierarchy process (AHP) decomposes complex decisions into structured smaller decisions, incorporates quantitative evidence and qualitative expert opinion, and promotes structured consensus building...
May 2017: Academic Radiology
https://www.readbyqxmd.com/read/28358677/ultrafast-synthetic-transmit-aperture-imaging-usta-using-hadamard-encoded-virtual-sources-with-overlapping-sub-apertures
#8
Ping Gong, Pengfei Song, Shigao Chen
The development of ultrafast ultrasound imaging offers great opportunities to improve imaging technologies such as shear wave elastography and ultrafast Doppler imaging. In Ultrafast imaging, there are trade-offs among image signal-to-noise ratio (SNR), resolution, and post-compounded frame rate. Various approaches have been proposed to solve this trade-off such as multiplane wave imaging or the attempts of implementing synthetic transmit aperture imaging. In this paper, we propose an Ultrafast Synthetic Transmit Aperture (USTA) imaging technique using Hadamard-encoded virtual sources with overlapping sub-apertures to enhance both image SNR and resolution without sacrificing frame rate...
March 24, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28332442/ultrasound-imaging-in-the-diagnosis-of-large-vessel-vasculitis
#9
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Nowadays noninvasive vascular imaging has an important role in the diagnostic work-up of the large vessel vasculitides (LVV), most importantly giant cell arteritis (GCA) and Takayasu arteritis. Among the imaging modalities available, ultrasound (US) has several important advantages, including low costs, rapid and repetitive availability without exposure to radiation, and high spatial resolution for assessment of large and medium-sized arteries. Therefore, US can be regarded the first line imaging method in suspected LVV...
March 23, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28288892/mr-image-guided-delivery-of-cisplatin-loaded-brain-penetrating-nanoparticles-to-invasive-glioma-with-focused-ultrasound
#10
Kelsie F Timbie, Umara Afzal, Abhijit Date, Clark Zhang, Ji Song, G Wilson Miller, Jung Soo Suk, Justin Hanes, Richard J Price
Systemically administered chemotherapeutic drugs are often ineffective in the treatment of invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of heterogeneously leaky microvessels, dense extracellular matrix and high interstitial pressure generate a "blood-tumor barrier" (BTB), which inhibits drug delivery and distribution. Meanwhile, beyond the contrast MRI-enhancing edge of the tumor, invasive cancer cells are protected by the intact blood-brain barrier (BBB). Here, we tested whether brain-penetrating nanoparticles (BPN) that possess dense surface coatings of polyethylene glycol (PEG) and are loaded with cisplatin (CDDP) could be delivered across both the blood-tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this treatment could control glioma growth and invasiveness...
March 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28280455/increasing-of-blood-brain-tumor-barrier-permeability-through-transcellular-and-paracellular-pathways-by-microbubble-enhanced-diagnostic-ultrasound-in-a-c6-glioma-model
#11
Jinlong Zhang, Heng Liu, Xuesong Du, Yu Guo, Xiao Chen, Shunan Wang, Jingqin Fang, Peng Cao, Bo Zhang, Zheng Liu, Weiguo Zhang
Most of the anticancer agents cannot be efficiently delivered into the brain tumor because of the existence of blood-brain tumor barrier (BTB). The objective of this study was to explore the effect of microbubble-enhanced diagnostic ultrasound (MEUS) on the BTB permeability and the possible mechanism. Glioma-bearing rats were randomized into three groups as follows: the microbubble-enhanced continued diagnostic ultrasound (MECUS) group; the microbubble-enhanced intermittent diagnostic ultrasound (MEIUS) group and the control group...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28268996/effects-of-phase-aberration-correction-methods-on-the-minimum-variance-beamformer
#12
Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello
The minimum variance (MV) beamformer is a method that has the potential to enhance the resolution and contrast of ultrasound images. However, it suffers from sensitivity to speed of sound errors and aberration. Although there have been several studies on the application of phase aberration correction (PAC) methods to conventional delay-and-sum (DAS) beamforming, the benefits of PAC methods in mitigating the effects of phase aberration in MV beamformed images are not well understood. A study of this type would be helpful in designing a robust beamformer based on PAC knowledge present in the literature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28243120/correlations-of-microvascular-blood-flow-of-contrast-enhanced-ultrasound-and-hgf-c-met-signaling-pathway-with-clinicopathological-features-and-prognosis-of-patients-with-hepatocellular-carcinoma
#13
Peng-Hui Zhuang, Lei Xu, Lu Gao, Wei Lu, Li-Tao Ruan, Jin Yang
The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathologically diagnosed as primary HCC were selected. All HCC patients underwent CEUS examination before operation. HCC tissues and adjacent normal tissue specimens were obtained to detect the protein rates of HGF and c-Met expressions by immunohistochemistry...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28240217/quantitative-ultrasound-molecular-imaging-by-modeling-the-binding-kinetics-of-targeted-contrast-agent
#14
Simona Turco, Isabelle Tardy, Peter Frinking, Hessel Wijkstra, Massimo Mischi
Ultrasound molecular imaging (USMI) is an emerging technique to monitor diseases at the molecular level by the use of novel targeted ultrasound contrast agents (tUCA). These consist of microbubbles functionalized with targeting ligands with high-affinity for molecular markers of specific disease processes, such as cancer-related angiogenesis. Among the molecular markers of angiogenesis, the vascular endothelial growth factor receptor 2 (VEGFR2) is recognized to play a major role. In response, the clinical-grade tUCA BR55 was recently developed, consisting of VEGFR2-targeting microbubbles which can flow through the entire circulation and accumulate where VEGFR2 is over-expressed, thus causing selective enhancement in areas of active angiogenesis...
March 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28230035/a-meta-analysis-of-contrast-enhanced-ultrasound-for-small-hepatocellular-carcinoma-diagnosis
#15
Huadong Deng, Hongwei Shi, Jianming Lei, Yan Hu, Gang Li, Chaojun Wang
OBJECTIVE: To discuss the efficacy of contrast-enhanced ultrasound (CEUS) for diagnosis of small hepatocellular carcinoma (HCC) by pooling the open published data. METHODS: A comprehensive publication electronic search was performed by reviewers in the databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure. The open published studies about CEUS for small HCC diagnosis were collected. The sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) were pooled by stata 12...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28227206/effects-of-phase-aberration-correction-methods-on-the-minimum-variance-beamformer
#16
Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello, Gustavo R Chau, Jeremy J Dahl, Roberto J Lavarello, Gustavo R Chau, Roberto J Lavarello
The minimum variance (MV) beamformer is a method that has the potential to enhance the resolution and contrast of ultrasound images. However, it suffers from sensitivity to speed of sound errors and aberration. Although there have been several studies on the application of phase aberration correction (PAC) methods to conventional delay-and-sum (DAS) beamforming, the benefits of PAC methods in mitigating the effects of phase aberration in MV beamformed images are not well understood. A study of this type would be helpful in designing a robust beamformer based on PAC knowledge present in the literature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28193267/abdominal-ultrasound-scanning-versus-non-contrast-computed-tomography-as-screening-method-for-abdominal-aortic-aneurysm-a-validation-study-from-the-randomized-dancavas-study
#17
Mads Liisberg, Axel C Diederichsen, Jes S Lindholt
BACKGROUND: Validating non-contrast-enhanced computed tomography (nCT) compared to ultrasound sonography (US) as screening method for abdominal aortic aneurysm (AAA) screening. METHODS: Consecutively attending men (n = 566) from the pilot study of the randomized Danish CardioVascular Screening trial (DANCAVAS trial), underwent nCT and US examination. Diameters were measured in outer-to-outer fashion. Sensitivity and specificity were done testing each modality against each other as reference standard...
February 14, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28186627/value-of-three-section-contrast-enhanced-transrectal-ultrasonography-in-the-detection-of-prostate-cancer
#18
Ting-Yue Qi, Hong-Guang Sun, Nian-Fen Li, Hao Feng, Yong-Ling Ding, Xiao-Xiang Wang
BACKGROUND: To assess the efficacy of three-section contrast-enhanced transrectal ultrasonography (CETRUS) in prostate cancer (PCa) detection. METHODS: A total of 169 consecutive patients with either PSA level ≥ 4 ng/ml or abnormal digital rectal examination findings were prospectively enrolled in this single center study. All patients underwent baseline transrectal ultrasonography (TRUS) and three-section CETRUS by one investigator blinded to any clinical data before TRUS-guided transperineal biopsy...
February 10, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28144721/focal-fat-deposition-in-the-liver-diagnostic-challenges-on-imaging
#19
REVIEW
Jong Keon Jang, Hyun-Jung Jang, Jin Sil Kim, Tae Kyoung Kim
While focal fat deposition in the liver mostly occurs in typical locations related to non-portal venous supply, unusual patterns of focal fat deposition, including multi-nodular, mass-like, and perivascular patterns, mimic malignancies and cause diagnostic challenges. Patients with unusual focal fat deposition often have potential underlying etiologies such as diabetes, alcohol abuse, metabolic disease, or various medications/chemotherapy. Some cases can be explained by non-portal venous supply or ischemia...
February 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28144402/impact-of-contrast-enhanced-ultrasound-in-patients-with-renal-function-impairment
#20
Rossano Girometti, Tiziano Stocca, Elena Serena, Antonio Granata, Michele Bertolotto
AIM: To investigate the role of contrast enhanced ultrasound (CEUS) in evaluating patients with renal function impairment (RFI) showing: (1) acute renal failure (ARF) of suspicious vascular origin; or (2) suspicious renal lesions. METHODS: We retrospectively evaluated patients addressed to CEUS over an eight years period to rule-out vascular causes of ARF (first group of 50 subjects) or assess previously found suspicious renal lesions (second group of 41 subjects with acute or chronic RFI)...
January 28, 2017: World Journal of Radiology
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