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Contrast enhanced ultrasound testes

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https://www.readbyqxmd.com/read/29323044/magnetic-resonance-imaging-guided-focused-ultrasound-to-increase-localized-blood-spinal-cord-barrier-permeability
#1
Allison H Payne, Gregory W Hawryluk, Yoshimi Anzai, Henrik Odéen, Megan A Ostlie, Ethan C Reichert, Amanda J Stump, Satoshi Minoshima, Donna J Cross
Spinal cord injury (SCI) affects thousands of people every year in the USA, and most patients are left with some permanent paralysis. Therapeutic options are limited and only modestly affect outcome. To address this issue, we used magnetic resonance imaging-guided focused ultrasound (MRgFUS) as a non-invasive approach to increase permeability in the blood-spinal cord barrier (BSCB). We hypothesize that localized, controlled sonoporation of the BSCB by MRgFUS will aid delivery of therapeutics to the injury. Here, we report our preliminary findings for the ability of MRgFUS to increase BSCB permeability in the thoracic spinal cord of a normal rat model...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322796/pitfalls-of-contrast-enhanced-ultrasound-ceus-in-determination-of-breast-tumor-biological-dignity
#2
V Lehotska, K Rauova, L Vanovcanova
The aim of this prospective study was to identify characteristics of breast lesions on contrast enhanced ultrasound (CEUS) that can be a source of diagnostic ambiguity and cause under- or overestimation of examined breast lesions. 215 women (range 23-76 y., mean age 53.16 y) with 215 breast lesions were examined by B-mode ultrasound, followed by CEUS and core biopsy. CEUS parameters: degree of opacification, character of washout and preliminary CEUS result (suspicious, non-suspicious, uncertain) were subsequently correlated with histopathological outcomes...
2018: Neoplasma
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#3
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29301827/thy1-targeted-microbubbles-for-ultrasound-molecular-imaging-of-pancreatic-ductal-adenocarcinoma
#4
Lotfi Abou-Elkacem, Huaijun Wang, Sayan M Chowdhury, Richard H Kimura, Sunitha V Bachawal, Sanjiv S Gambhir, Lu Tian, Juergen K Willmann
PURPOSE: To engineer a dual human and murine Thy1-binding single-chain-antibody ligand (Thy1-scFv) for contrast microbubble-enhanced ultrasound molecular imaging of pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN:  Thy1-scFv were engineered using yeast-surface-display techniques. Binding to soluble human and murine Thy1 and to Thy1-expressing cells was assessed by flow cytometry. Thy1-scFv was then attached to gas-filled microbubbles to create MB Thy1-scFv...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29287999/the-dependence-of-glomerular-capillary-hemorrhage-induced-by-contrast-enhanced-diagnostic-ultrasound-on-microbubble-diameter
#5
Douglas L Miller, Xiaofang Lu, Chunyan Dou, Mario L Fabiilli, Charles C Church
A recently proposed two-criterion model for cavitational bioeffects in tissue with microbubbles (MBs) was tested. The glomerular capillary hemorrhage bioeffect was observed in rat kidney for contrast agent MB suspensions with mean diameters of 1.6, 3.1 and 5.5 µm. A diagnostic ultrasound machine was used at 3.6 MHz and 5.5 MHz for intermittent scans at power settings 2 dB apart. Petechial hemorrhage counts scored on the surface of the kidneys, and glomeruli were scored in histology. Thresholds for the petechial hemorrhage measurements were the same for the large and medium MB suspensions but substantially higher for the small MBs...
December 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29238867/a-direct-comparison-of-contrast-enhanced-ultrasound-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-prostate-cancer-detection-and-prediction-of-aggressiveness
#6
Alexander D J Baur, Julia Schwabe, Julian Rogasch, Andreas Maxeiner, Tobias Penzkofer, Carsten Stephan, Marc Rudl, Bernd Hamm, Ernst-Michael Jung, Thom Fischer
INTRODUCTION: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness. MATERIAL AND METHODS: A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29237797/endothelial-progenitor-cells-enhance-blood-brain-barrier-permeability-in-subacute-stroke
#7
João Sargento-Freitas, Sezin Aday, César Nunes, Miguel Cordeiro, Ana Gouveia, Fernando Silva, Cristina Machado, Bruno Rodrigues, Gustavo Cordeiro Santo, Carlos Ferreira, André Amorim, Susana Sousa, Ana Catarina Gomes, Miguel Castelo-Branco, Lino Ferreira, Luís Cunha
OBJECTIVE: To study the association among endothelial progenitor cells (EPCs), subacute blood-brain barrier (BBB) permeability, and clinical outcome after ischemic stroke, determining the micro RNAs of EPCs responsible for good clinical outcome. METHODS: We included consecutive patients with nonlacunar acute ischemic strokes in the territory of a middle cerebral artery and ages between 18 and 80 years. Clinical outcome was defined as modified Rankin Scale score at 3 months...
December 13, 2017: Neurology
https://www.readbyqxmd.com/read/29226274/virtual-dissection-by-ultrasound-probe-handling-in-the-first-year-of-medical-education
#8
Graziano Serrao, Massimo Tassoni, Alberto M Magenta-Biasina, Antonio Giuseppe Mantero, Antonino Previtera, Michela Crisitna Turci, Elia Mario Biganzoli, Emanuela A M Bertolini
Objectives: The aim of the present study was to assess the educational plan of first-year students of medicine by analyzing their scores in ultrasound body scanning. Methods: Since 2009, the San Paolo Medical School (Milan, Italy) has vertically integrated the study of anatomy with ultrasound-assisted virtual body dissection. Three modules were supplied: musculoskeletal system, heart and abdomen pelvis. 653 first-year students were trained. The students alternated as mutual model and operator...
September 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/29179281/-effects-of-different-computed-high-b-values-on-diffusion-weighted-imaging-scores-in-prostate-imaging-reporting-and-data-system-version-2-of-prostate-cancer-in-peripheral-zone
#9
W Wang, Z H Shao, J Q Zeng, D L Wu, G L Wang, P J Wang
Objective: To determine the effects of different computed high b-value on diffusion weighted imaging (DWI) scores in Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) of prostate cancer in peripheral zone. Methods: A retrospective study of 104 cases of prostate cancer in peripheral zone was conducted, all of the patients were histopathologically confirmed by transrectal ultrasound guided saturation biopsy or radical prostatectomy in Tongji Hospital of Tongji University from January 2012 to December 2015...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29162410/diagnostic-performance-of-contrast-enhanced-ultrasound-for-pancreatic-neoplasms-a-systematic-review-and-meta-analysis
#10
Xing-Zhao Li, Jun Song, Zhi-Xia Sun, Yan-Yan Yang, Hui Wang
BACKGROUND: Early diagnosis of pancreatic cancer is essential to optimize treatment strategies. OBJECTIVES: To evaluate the diagnostic performance of contrast-enhanced ultrasound for benign and malignant pancreatic neoplasms. DATA SOURCES: Pubmed, Embase, Web of Science, and Cochrane Library databases. STUDY ELIGIBILITY CRITERIA: Retrospective or prospective studies. PARTICIPANTS: Patients with a confirmed diagnosis of benign and malignant pancreatic neoplasms...
November 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29157067/role-of-endoscopic-ultrasound-in-the-management-of-tubercular-uveitis
#11
Deepa Sharma, Manisha Agarwal, Vikas Singla, Vivek Jha, Ankita Shrivastav
PURPOSE: To evaluate the role and safety of endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) in patients of tubercular uveitis. DESIGN: Interventional case series Methods: Thirty patients suspected of tubercular uveitis that underwent EUS-FNAC were enrolled in the study. The patient details recorded were age, gender, systemic history, ocular complaints and clinical manifestations. The details of the investigations - skin test, X-Ray chest, CECT (contrast enhanced computed tomography) of chest and findings on EUS-FNAC were also recorded...
November 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29131073/an-introduction-to-contrast-enhanced-ultrasound-for-nephrologists
#12
Emily H Chang
Contrast-enhanced ultrasound (CEUS) is an emerging technology with no known nephrotoxicity. CEUS has been utilized in cardiac and abdominal imaging for decades in Asia and Europe and has recently received greater attention in the United States with its approval for characterization of indeterminate liver lesions. Emerging data suggest that CEUS has potential as a diagnostic imaging tool among individuals who have contraindications to CT and MRI. Few nephrologists are aware of CEUS and even fewer are aware of its potential applications among individuals with kidney disease...
November 9, 2017: Nephron
https://www.readbyqxmd.com/read/29119649/prospective-multimodal-imaging-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery-the-price-prospective-imaging-of-cervical-cancer-and-neoadjuvant-treatment-study-2-the-role-of-ultrasound-after
#13
Antonia Carla Testa, Francesca Moro, Tina Pasciuto, Maria Cristina Moruzzi, Alessia Di Legge, Gilda Fuoco, Rosa Autorino, Angela Collarino, Benedetta Gui, Gian Franco Zannoni, Antonietta Gambacorta, Maura Miccò, Vittoria Rufini, Giovanni Scambia, Gabriella Ferrandina
OBJECTIVE: To determine the diagnostic performance of two-dimensional ultrasound parameters, three-dimensional power Doppler and intravenous contrast enhanced indices in detecting residual disease in locally advanced cervical cancer patients triaged to neoadjuvant treatment followed by radical surgery. METHODS: Between October 2010 and June 2014, 108 women with histologically documented cervical cancer and FIGO stage IB2-IVA were screened and 88 of them were included in the final analysis...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#14
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29052791/potential-diagnostic-performance-of-contrast-enhanced-ultrasound-and-tumor-markers-in-differentiating-combined-hepatocellular-cholangiocarcinoma-from-hepatocellular-carcinoma-and-cholangiocarcinoma
#15
Xiao-Wen Huang, Yang Huang, Li-da Chen, Zhu Wang, Zheng Yang, Jin-Ya Liu, Xiao-Yan Xie, Ming-De Lu, Shun-Li Shen, Wei Wang
PURPOSE: To evaluate the diagnostic performance of the combination of tumor markers [alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9)] and imaging features in differentiating combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). METHODS: Forty consecutive patients with pathologically proven CHC were retrospectively evaluated with contrast-enhanced ultrasound (CEUS). Additionally, 40 HCC and 40 CC patients who were randomly selected from the same period served as a control group...
October 20, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28970709/comparison-of-contrast-enhanced-ultrasound-with-contrast-enhanced-computed-tomography-for-the-diagnosis-of-hepatocellular-carcinoma
#16
Sandeep Moudgil, Naveen Kalra, Nidhi Prabhakar, Radha Krishan Dhiman, Arunanshu Behera, Yogesh Kumar Chawla, Niranjan Khandelwal
BACKGROUND/AIMS: The most common primary malignant tumor of liver is hepatocellular carcinoma (HCC). The highest risk of developing HCC is seen in patients of cirrhosis. Ultrasound is used for surveillance in these patients. This study evaluates the role of contrast enhanced ultrasound (CEUS) in the diagnosis of HCC and compares CEUS to contrast enhanced computed tomography (CECT). MATERIALS AND METHODS: This prospective study included 22 patients with cirrhosis and suspected to have HCC on the basis of gray scale ultrasound or elevated Alpha-fetoprotein...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28951947/cholangiocarcinoma-and-its-mimickers-in-primary-sclerosing-cholangitis
#17
REVIEW
Jonghun John Lee, Sebastian T Schindera, Hyun-Jung Jang, Scott Fung, Tae Kyoung Kim
Cholangiocarcinoma (CCA) is the most common malignancy in primary sclerosing cholangitis (PSC). Approximately half of CCA are diagnosed within two years of initial diagnosis and often have a poor prognosis because of advanced tumor stage at the time of diagnosis. Thus, rigorous initial imaging evaluation for detecting CCA is important. CCA in PSC usually manifests as intrahepatic mass-forming or perihilar periductal-infiltrating type. Imaging diagnosis is often challenging due to pre-existing biliary strictures and heterogeneous liver...
September 26, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28940870/assessment-of-cerebral-perfusion-with-contrast-enhanced-ultrasound-during-constriction-of-the-neck-mimicking-malposition-of-the-bd-odon-device%C3%A2-a-study-in-newborn-piglets
#18
C de Lange, O D Saugstad, R Solberg
OBJECTIVE: The BD Odon Device™ is a new instrument for operative vaginal birth with potential for preventing maternal, fetal and newborn morbidity/mortality during a complicated second stage of labour. The device is a plastic sleeve with an air chamber inflated around the baby's head which is gently pulled through the birth canal. The aim was to monitor changes in cerebral circulation during constriction of the neck to evaluate a risk of potential malposition of the device. DESIGN: Randomised prospective study...
September 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28932826/interobserver-variation-of-the-bolus-and-burst-method-for-pancreatic-perfusion-with-dynamic-contrast-enhanced-ultrasound
#19
Marcus Stangeland, Trond Engjom, Martin Mezl, Radovan Jirik, Odd Helge Gilja, Georg Dimcevski, Kim Nylund
PURPOSE: Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems. MATERIALS AND METHODS: Ten patients under evaluation for exocrine pancreatic failure were included...
June 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28926263/copper-sulfide-perfluorocarbon-nanodroplets-as-clinically-relevant-photoacoustic-ultrasound-imaging-agents
#20
Daniela Y Santiesteban, Diego S Dumani, Daniel Profili, Stanislav Y Emelianov
We have developed laser-activated perfluorocarbon nanodroplets containing copper sulfide nanoparticles (CuS NPs) for contrast-enhanced ultrasound and photoacoustic imaging. As potential clinical contrast agents, CuS NPs have favorable properties including biocompatibility, biodegradability, and enhance contrast in photoacoustic images at clinically relevant depths. However, CuS NPs are not efficient optical absorbers when compared to plasmonic nanoparticles and therefore, contrast enhancement with CuS NPs is limited, requiring high concentrations to generate images with sufficient signal-to-noise ratio...
October 11, 2017: Nano Letters
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