Julia B Kral-Pointner, Patrick Haider, Petra L Szabo, Manuel Salzmann, Mira Brekalo, Karl H Schneider, Waltraud C Schrottmaier, Christoph Kaun, Sonja Bleichert, Attila Kiss, Romana Sickha, Christian Hengstenberg, Kurt Huber, Christine Brostjan, Helga Bergmeister, Alice Assinger, Bruno K Podesser, Johann Wojta, Philipp Hohensinner
BACKGROUND: Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets and endothelial cells. Thus, we aimed to modulate leukocyte function during thrombus resolution post-thrombus formation by blocking P-selectin/CD62P-mediated cell interactions. METHODS: Thrombosis was induced by inferior vena cava stenosis through ligation in mice...
February 22, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology