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https://www.readbyqxmd.com/read/27909839/biventricular-support-using-a-centrifugal-pump-in-a-6%C3%A2-year-old-with-fulminant-myocarditis
#1
Hiromu Kehara, Tamaki Takano, Takamitsu Terasaki, Kenji Okada
We experienced a case of ventricular assist with both a pulsatile-flow and a continuous-flow pump in a pediatric patient, and herein report the clinical course and characteristics of the pumps. A 6-year-old female was diagnosed with fulminant myocarditis and transferred to our hospital for mechanical support. After 12 days of extracorporeal membrane oxygenation, we implanted a left ventricular assist device (LVAD) and a right ventricular assist device (RVAD) using centrifugal Gyro pumps with a membrane oxygenator in a paracorporeal fashion...
December 1, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27819526/the-effects-of-hydrogen-sulfide-on-platelet-leukocyte-aggregation-and-microvascular-thrombolysis
#2
Eberhard Grambow, Christian Leppin, Katja Leppin, Günther Kundt, Ernst Klar, Marcus Frank, Brigitte Vollmar
The volatile transmitter hydrogen sulfide (H2S) is known for its various functions in vascular biology. This study evaluates the effect of the H2S-donor GYY4137 (GYY) on thrombus stability and microvascular thrombolysis. Human whole blood served for all in vitro studies and was analyzed in a resting state, after stimulation with thrombin-receptor activating peptide (TRAP) and after incubation with 10 or 30 mM GYY or its vehicle DMSO following TRAP-activation, respectively. As a marker for thrombus stability, platelet-leukocyte aggregation was assessed using flow cytometry after staining of human whole blood against CD62P and CD45, respectively...
November 7, 2016: Platelets
https://www.readbyqxmd.com/read/27810245/-severe-pulmonary-embolism-revealed-by-status-epilepticus
#3
N Allou, N Coolen-Allou, B Delmas, C Cordier, J Allyn
INTRODUCTION: High-risk pulmonary embolism (PE) is associated with high mortality rate (>50%). In some cases, diagnosis of PE remains a challenge with atypical presentations like in this case report with a PE revealed by status epilepticus. CASE REPORT: We report the case of a 40-year-old man without prior disease, hospitalized in ICU for status epilepticus. All paraclinical examinations at admission did not show any significant abnormalities (laboratory tests, cardiologic and neurological investigations)...
October 31, 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27780803/emerging-anticoagulant-strategies
#4
James C Fredenburgh, Peter L Gross, Jeffrey I Weitz
Despite the introduction of direct oral anticoagulants (DOACs), the search for more effective and safer antithrombotic strategies continues. Better understanding of the pathogenesis of thrombosis has fostered two new approaches to achieving this goal. First, evidence that thrombin may be as important as platelets to thrombosis at sites of arterial injury and that platelets contribute to venous thrombosis has prompted trials comparing anticoagulants with aspirin for secondary prevention in arterial thrombosis and aspirin with anticoagulants for primary and secondary prevention of venous thrombosis...
October 25, 2016: Blood
https://www.readbyqxmd.com/read/27692635/-is-regression-of-atherosclerotic-plaque-possible
#5
José A Páramo, Fernando Civeira
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion ('angiographic paradox')...
September 27, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27688592/release-of-experimental-retinal-vein-occlusions-by-direct-intraluminal-injection-of-ocriplasmin
#6
Marc D de Smet, Jean Marie Stassen, Thijs C M Meenink, Tom Janssens, Valérie Vanheukelom, Gerrit J L Naus, Maarten J Beelen, Bart Jonckx
PURPOSE: Retinal vein occlusions (RVO) are a major cause of vision loss in people aged 50 years and older. Current therapeutic options limit the consequences of RVO but do not eliminate the cause. Cannulation of the involved vessel and removal of the clot may provide a more permanent solution with a less demanding follow-up. However, cannulation of smaller retinal veins remains challenging. This paper explores the use of ocriplasmin (recombinant plasmin without its kringles) to clear RVO, using a robotic micromanipulator...
September 28, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27632423/synthesis-and-biological-evaluation-of-cyclic-99m-tc-hynic-cgprppc-as-a-fibrin-binding-peptide-for-molecular-imaging-of-thrombosis-and-its-comparison-with-99m-tc-hynic-gprpp
#7
Sedigheh Rezaeianpour, Atefeh Hajiagha Bozorgi, Abolghasem Moghimi, Ameneh Almasi, Saeed Balalaie, Sorour Ramezanpour, Sanaz Nasoohi, Seyed Mohammad Mazidi, Parham Geramifar, Ahmad Bitarafan-Rajabi, Soraya Shahhosseini
PURPOSE: Many patients worldwide suffer from cardiovascular diseases for which an underlying factor is thrombosis. Devising a molecular imaging technique for early detection of thrombosis in a clinical setting is highly recommended. Because fibrin is a major constituent of clots and is present in all types of thrombi but absent in circulation, it is a highly specific and sensitive target for molecular imaging of thrombi. It is assumed that cyclization of peptides will improve the receptor binding affinity and stability of the peptide...
September 8, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27608787/acute-myocardial-infarction-in-nephrotic-syndrome
#8
Kavita Krishna, Shirish Hiremath, Sachin Lakade, Sudarshan Davakhar
A 28 year old male, known case of nephrotic syndrome since 12 years, hypertensive presented with acute myocardial infarction (AMI) and accelerated hypertension. Coronary angiography revealed 100% thrombotic occlusion of mid left anterior descending artery, treated with thrombus aspiration and intracoronary tirofiban and nitroglycerine. He was stabilized within 24 hours. The pathogenesis of AMI in nephrotic syndrome has been discussed with this case report.
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27578806/effective-anti-thrombotic-therapy-without-stenting-intravascular-optical-coherence-tomography-based-management-in-plaque-erosion-the-erosion-study
#9
Haibo Jia, Jiannan Dai, Jingbo Hou, Lei Xing, Lijia Ma, Huimin Liu, Maoen Xu, Yuan Yao, Sining Hu, Erika Yamamoto, Hang Lee, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
AIMS: Plaque erosion, compared with plaque rupture, has distinctly different underlying pathology and therefore may merit tailored therapy. In this study, we aimed to assess whether patients with acute coronary syndrome (ACS) caused by plaque erosion might be stabilized by anti-thrombotic therapy without stent implantation. METHODS AND RESULTS: This was a single-centre, uncontrolled, prospective, proof-of concept study. Patients with ACS including ST-segment elevation myocardial infarction were prospectively enrolled...
August 30, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27574455/meta-analysis-of-the-prognostic-value-of-abnormally-expressed-lncrnas-in-hepatocellular-carcinoma
#10
Zhen Qu, Chun-Hui Yuan, Chang-Qing Yin, Qing Guan, Hao Chen, Fu-Bing Wang
Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in hepatocellular carcinoma (HCC), and may have the potential to serve as prognostic markers. In this study, a meta-analysis was conducted to systematically evaluate the prognostic value of various lncRNAs in HCC. Eligible literatures were systematically collected from PubMed, Embase, Web of Science, and Cochrane Library (up to December 30, 2015). The main outcomes including overall survival, relapse-free survival, and disease-free survival were analyzed...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27555152/cardiac-arrest-during-radical-nephrectomy-due-to-a-mass-in-the-right-ventricular-outflow-tract
#11
Hee Young Kim, Seung-Hoon Baek, Ji Uk Yoon, Dong Hoon Lee, Gyeong-Jo Byeon, Ji Hye Ahn
We report cardiac arrest due to obstruction of the right ventricular outflow tract (RVOT) caused by an RVOT mass that was not identified preoperatively. A 62-year-old woman with renal cell carcinoma (RCC) experienced deteriorating hypotension and bradycardia during radical nephrectomy. Hemodynamic stability was maintained on extracorporeal membrane oxygenation, and after surgery, she was transferred to the intensive care unit. On postoperative day 3, transthoracic echocardiography showed an intracardiac mass obstructing the RVOT, which caused severe functional pulmonary stenosis and moderate resting pulmonary hypertension...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27530412/endovascular-stent-grafting-of-the-ascending-aorta-for-symptomatic-parietal-thrombus
#12
Andrea Kahlberg, Matteo Montorfano, Tommaso Cambiaghi, Luca Bertoglio, Germano Melissano, Roberto Chiesa
PURPOSE: To present stent-graft treatment of parietal thrombus in the ascending aorta. CASE REPORT: A 64-year-old man with no history of vascular disease developed a right cerebral hemisphere transient ischemic attack and was diagnosed with mural thrombosis of the ascending aorta involving the greater curvature just proximal to the origin of the innominate artery. He was treated for 2 months with anticoagulants, but new imaging studies showed significant increase in the size of the thrombus and an irregular aspect...
August 16, 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27494773/the-tyrosine-kinase-inhibitor-nilotinib-potentiates-a-prothrombotic-state
#13
Naif Alhawiti, Kate L Burbury, Faith A Kwa, Cindy J O'Malley, Peter Shuttleworth, Mohamad Alzard, Abdullah Hamadi, Andrew P Grigg, Denise E Jackson
Tyrosine kinase inhibitors (TKI) such as imatinib, nilotinib and dasatinib are now established as highly effective frontline therapies for chronic myeloid leukaemia (CML). Disease control is achieved in the majority of patients and survival is excellent such that recent focus has been on toxicities of these agents. Cumulative data have reported an excess of serious vascular complications, including arterial thrombosis and peripheral arterial occlusive disease, in patients receiving nilotinib in comparison with other TKIs, with resultant interest in delineating the pathophysiology and implications for rationale cardiovascular risk modification...
September 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27458520/modification-of-shape-memory-polymer-foams-using-tungsten-aluminum-oxide-and-silicon-dioxide-nanoparticles
#14
S M Hasan, R S Thompson, H Emery, A L Nathan, A C Weems, F Zhou, M B B Monroe, D J Maitland
Shape memory polymer (SMP) foams were synthesized with three different nanoparticles (tungsten, silicon dioxide, and aluminum oxide) for embolization of cerebral aneurysms. Ultra-low density SMP foams have previously been utilized for aneurysm occlusion, resulting in a rapid, stable thrombus. However, the small cross section of foam struts can potentially lead to fracture and particulate generation, which would be a serious adverse event for an embolic device. The goal of this study was to improve the mechanical properties of the system by physically incorporating fillers into the SMP matrix...
2016: RSC Advances
https://www.readbyqxmd.com/read/27351623/primary-pleomorphic-liposarcoma-of-the-spine-case-report-and-review-of-the-literature
#15
A M Morales-Codina, J A Martín-Benlloch, M Corbellas Aparicio
INTRODUCTION: To describe a single case, the fourth ever reported, of pleomorphic liposarcoma of the spine and to undertake a review of the literature. PRESENTATION OF CASE: A 60 year old male patient had a bilateral lumbosciatica over a 3 month period. Imaging tests revealed a tumor mass in L1-L3 and a fracture in L2. Also, he had a mural thrombus both in the inferior vena cava and the left renal vein. The biopsy revealed a well-differentiated liposarcoma. En bloc resection of the lesion and stabilization was carried out...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27345378/acute-renal-artery-occlusion-presentation-treatment-and-outcome
#16
Daniel Silverberg, Tehillah Menes, Uri Rimon, Ophira Salomon, Moshe Halak
OBJECTIVE: Acute renal artery occlusion is an uncommon disease requiring rapid diagnosis for prevention of kidney loss or permanent kidney damage. The purpose of this study was to identify patients with acute kidney infarction; to characterize their presentation, imaging, and treatment; and to compare the subgroup of patients who underwent catheter-directed thrombolysis (CDT) with those who were treated without intervention. METHODS: Hospital records between 2005 and 2015 were queried for keywords suggestive of kidney infarction...
October 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27312021/-management-of-hypercholesterolemia-in-patients-with-acute-coronary-syndrome-current-mechanisms-and-future-perspectives
#17
Maddalena Lettino
Acute coronary syndromes (ACS) are a major health problem both in industrialized countries and in developing ones, and a leading cause of death and disability. The pathogenesis of ACS is multifactorial and complex, with approximately 65-70% of cases caused by the abrupt occlusion of a coronary vessel. This usually occurs as a result of thrombus formation over a vulnerable, lipid-rich atherosclerotic plaque, which undergoes rupture or erosion. High levels of LDL-cholesterol (LDL-C) are a well known risk factor for the development of atherosclerosis, and the reduction in plasma LDL-C is a fundamental treatment both in primary and secondary prevention...
April 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27282310/factor-xii-form-determines-function
#18
REVIEW
S de Maat, C Maas
Factor XII is a mysterious plasma protein without a clear physiologic function. It was identified as a clotting factor, but has no clear role in hemostasis. However, FXII also contributes to the production of bradykinin, a short-lived inflammatory peptide. A growing body of mechanistic research from animal models indicates that FXII contributes to thrombotic disease by triggering excessive coagulation. FXII is evolutionarily conserved, suggesting that this molecule does have a physiologic function. This leads to intriguing questions: What does FXII really do? Is it even a real clotting factor at all? Before the groundbreaking discovery of a role for FXII in thrombotic disease, many studies investigated the biochemical properties of FXII and its activators...
August 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27270147/-a-case-of-carotid-free-floating-thrombus-treated-by-carotid-ultrasonography-guided-endovascular-approach
#19
Masato Otawa, Takeshi Kinkori, Kenichi Watanabe, Ryo Ando, Masao Tambara, Toru Arima
We experienced a case of carotid free-floating thrombus treated by carotid ultrasonography-guided endovascular approach. A 63-year-old man was brought to our hospital with the chief complaint of sudden onset left hemiplegia. MRI revealed acute infarction of the right MCA territory due to the right M1 occlusion. Carotid ultrasonography showed a pedunculated, polypoid mobile plaque floating with the cardiac beat. We attempted ultrasonography-guided endovascular treatment. Under proximal balloon protection, the floating plaque was successfully aspirated into the Penumbra aspiration catheter...
June 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27266264/intraprocedural-left-ventricular-free-wall-rupture-diagnosed-by-left-ventriculogram-in-a-patient-with-infero-posterior-myocardial-infarction-and-severe-aortic-stenosis
#20
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Hiroshi Nishihara, Daisuke Hotta, Kenjiro Kikuchi, Hideo Yokoyama, Katsumi Ohori
BACKGROUND: Left ventricular wall rupture remains a major lethal complication of acute myocardial infarction and hypertension is a well-known predisposing factor of cardiac rupture after myocardial infarction. CASE PRESENTATION: An 87-year-old man was admitted to our hospital, diagnosed as acute myocardial infarction (AMI). The echocardiogram showed 0.67-cm(2) aortic valve, consistent with severe aortic stenosis (AS). A coronary angiography showed a chronic occlusion of the proximal left circumflex artery and a 99 % stenosis and thrombus in the mid right coronary artery...
2016: BMC Cardiovascular Disorders
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