keyword
https://read.qxmd.com/read/38526607/the-efficacy-and-safety-of-pd-1-inhibitor-combined-with-tace-in-the-first-line-treatment-of-unresectable-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Qing-Qing Liu, Xiang-Xu Wang, Hongchen Ji, Qiong-Yi Dou, Hong-Mei Zhang
The application of immune checkpoint inhibitors (ICIs) has changed the treatment of advanced hepatocellular carcinoma. Transcatheter arterial chemoembolization (TACE) is a first-line treatment for intermediate hepatocellular carcinoma. Serving as a local treatment modality that can induce immunogenic cell death, the efficacy and safety of combined use with ICI have not been evaluated. Although there have been prospective studies aimed at evaluating the efficacy and safety of ICI combined with TACE in BCLC stage B HCC patients, there are few reports on the evaluation of BCLC stage C patients with distant metastasis or portal vein cancer thrombus...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38525920/double-crosslinking-decellularized-bovine-pericardium-of-dialdehyde-chondroitin-sulfate-and-zwitterionic-copolymer-for-bioprosthetic-heart-valves-with-enhanced-antithrombogenic-anti-inflammatory-and-anti-calcification-properties
#2
JOURNAL ARTICLE
Shubin Shi, Mengyue Hu, Xu Peng, Can Cheng, Shaoxiong Feng, Xinyun Pu, Xixun Yu
Due to the increasing aging population and the advancements in transcatheter aortic valve replacement (TAVR), the use of bioprosthetic heart valves (BHVs) in patients diagnosed with valvular disease has increased substantially. Commercially available glutaraldehyde (GA) cross-linked biological valves suffer from reduced durability due to a combination of factors, including the high cell toxicity of GA, subacute thrombus, inflammation and calcification. In this study, oxidized chondroitin sulfate (OCS), a natural polysaccharide derivative, was used to replace GA to cross-link decellularized bovine pericardium (DBP), carrying out the first crosslinking of DBP to obtain OCS-BP...
March 25, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38481892/spontaneous-adductor-hematoma-in-a-75-year-old-male-with-acute-thigh-bruises
#3
James Kim, Hye Chang Rhim, Jeffrey C Schneider
Patients with a history of blood clots are commonly placed on anticoagulation therapy, but a common adverse effect of this therapy is hemorrhage. Our patient with a history of left ventricle thrombus in a free-standing inpatient rehabilitation hospital had ecchymoses that expanded over a large portion of the posterior thigh in one day. The rapid expansion of the ecchymoses coupled with a decline in hemoglobin levels prompted an immediate evaluation that showed an intramuscular hematoma. With hemoglobin levels dropping significantly, the patient was then transferred to the emergency department for higher levels of care...
February 2024: Curēus
https://read.qxmd.com/read/38462108/a-synergistic-strategy-based-on-active-hydroxymethyl-amine-compounds-and-fucoidan-for-bioprosthetic-heart-valves-with-enhancing-anti-coagulation-and-anti-calcification-properties
#4
JOURNAL ARTICLE
Hongxia Pu, Canyu Wang, Tao Yu, Xiaotong Chen, Gaocan Li, Da Zhu, Xiangbin Pan, Yunbing Wang
With an aging population, the patients with valvular heart disease (VHD) are growing worldwide, and valve replacement is a primary choice for these patients with severe valvular disease. Among them, bioprosthetic heart valves (BHVs), especially BHVs trough transcatheter aortic valve replacement, are widely accepted by patients on account of their good hemodynamics and biocompatibility. Commercial BHVs in clinic are prepared by glutaraldehyde cross-linked pericardial tissue with the risk of calcification and thrombotic complications...
March 8, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38461446/design-and-performance-analysis-of-a-new-inferior-vena-cava-filter
#5
JOURNAL ARTICLE
Xianying Wang, Huajie Wang, Hongliang Qian, Hongdong Su, Deda Lou, Lijian Tian, Deshen Chen, Huafang Ding, Feng Fan
This study proposes a novel inferior vena cava filter (IVCF) design, "Lotus," aiming to enhance release stability and endothelialization. A catheter-filter-vessel model was established for IVCF property analysis, validated by comparing numerical simulations and in vitro tests. Lotus's mechanical properties were analyzed, and optimization suggestions are provided. Compared to existing clinical filters, Lotus demonstrates improved release stability and thrombus capture ability. This work suggests Lotus as a potential technical reference for improved IVCF treatment...
March 10, 2024: Computer Methods in Biomechanics and Biomedical Engineering
https://read.qxmd.com/read/38435796/influence-of-hematocrit-level-and-integrin-%C3%AE-iib-%C3%AE-iii-function-on-vwf-mediated-platelet-adhesion-and-shear-induced-platelet-aggregation-in-a-sudden-expansion
#6
JOURNAL ARTICLE
Connor T Watson, Shane C Ward, Stefano A Rizzo, Alberto Redaelli, Keefe B Manning
PURPOSE: Shear-mediated thrombosis is a clinically relevant phenomenon that underlies excessive arterial thrombosis and device-induced thrombosis. Red blood cells are known to mechanically contribute to physiological hemostasis through margination of platelets and vWF, facilitating the unfurling of vWF multimers, and increasing the fraction of thrombus-contacting platelets. Shear also plays a role in this phenomenon, increasing both the degree of margination and the near-wall forces experienced by vWF and platelets leading to unfurling and activation...
February 2024: Cellular and Molecular Bioengineering
https://read.qxmd.com/read/38419677/nanomicrosphere-sustained-release-urokinase-systems-with-antioxidant-properties-for-deep-vein-thrombosis-therapy
#7
JOURNAL ARTICLE
Shun Xiao, Xiaozhi Sun, Chong Wang, Jianlie Wu, Kun Zhang, Mingjin Guo, Bing Liu
Deep vein thrombosis (DVT) is a venous return disorder caused by abnormal clotting of blood in deep veins. After thrombosis, most of the thrombus will spread to the deep vein trunk throughout the limb. If DVT is not treated in time, most of them will develop into thrombosis sequelae and even threaten life. Intravenous thrombolytic drugs are the most promising strategy for treating DVT, but current drugs used for thrombolysis suffer from short half-lives and narrow therapeutic indexes. To effectively manage DVT, it is necessary to develop a novel multifunctional drug-loading system to effectively prolong the treatment time and improve the therapeutic efficacy...
February 21, 2024: RSC Advances
https://read.qxmd.com/read/38395360/involvement-of-peptidylarginine-deiminase-4-in-eosinophil-extracellular-trap-formation-and-contribution-to-citrullinated-histone-signal-in-thrombi
#8
JOURNAL ARTICLE
Kimberly Martinod, Frederik Denorme, Severien Meyers, Marilena Crescente, Stijn Van Bruggen, Mathias Stroobants, Patrick M Siegel, Ramesh Grandhi, Katharina Glatz, Thilo Witsch
BACKGROUND: Extracellular traps formed by neutrophils (NETs) and eosinophils (EETs) have been described in coronary thrombi, contributing to thrombus stability. A key mechanism during NET formation is histone modification by the enzyme PAD4. Citrullinated histones, the product of PAD4 activity, are often attributed to neutrophils. Eosinophils also express high levels of PAD4 but the contribution of PAD4 to EET formation is not known. METHODS: We performed immunohistological analyses on thrombi, including a large, intact and eosinophil-containing thrombus retrieved from the right coronary artery using an aspiration catheter and stroke thrombi from thrombectomy retrieval...
February 21, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38385292/reduced-monocyte-and-neutrophil-infiltration-and-activation-by-p-selectin-cd62p-inhibition-enhances-thrombus-resolution
#9
JOURNAL ARTICLE
Julia B Kral-Pointner, Patrick Haider, Petra L Szabo, Manuel Salzmann, Mira Brekalo, Karl H Schneider, Waltraud C Schrottmaier, Christoph Kaun, Sonja Bleichert, Attila Kiss, Romana Sickha, Christian Hengstenberg, Kurt Huber, Christine Brostjan, Helga Bergmeister, Alice Assinger, Bruno K Podesser, Johann Wojta, Philipp Hohensinner
BACKGROUND: Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets and endothelial cells. Thus, we aimed to modulate leukocyte function during thrombus resolution post-thrombus formation by blocking P-selectin/CD62P-mediated cell interactions. METHODS: Thrombosis was induced by inferior vena cava stenosis through ligation in mice...
February 22, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38379711/contractility-defects-hinder-glycoprotein-vi-mediated-platelet-activation-and-affect-platelet-functions-beyond-clot-contraction
#10
JOURNAL ARTICLE
Martin Kenny, Alice Y Pollitt, Smita Patil, Dishon W Hiebner, Albert Smolenski, Natalija Lakic, Robert Fisher, Reema Alsufyani, Sebastian Lickert, Viola Vogel, Ingmar Schoen
BACKGROUND: Active and passive biomechanical properties of platelets contribute substantially to thrombus formation. Actomyosin contractility drives clot contraction required for stabilizing the hemostatic plug. Impaired contractility results in bleeding but is difficult to detect using platelet function tests. OBJECTIVES: To determine how diminished myosin activity affects platelet functions, including and beyond clot contraction. METHODS: Using the myosin IIA-specific pharmacologic inhibitor blebbistatin, we modulated myosin activity in platelets from healthy donors and systematically characterized platelet responses at various levels of inhibition by interrogating distinct platelet functions at each stage of thrombus formation using a range of complementary assays...
January 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38359399/preparation-and-hemocompatibility-of-novel-antioxidant-modified-polyethersulfone-membranes-as-red-blood-cell-thrombosis-inhibitors
#11
JOURNAL ARTICLE
Xiao Fu, Ting Lei, Shitao Song, Luling Xia, Yuan Xiao, Gong Xiao
The contact between the dialysis membrane and blood can induce oxidative stress (OS) and thrombosis, causing oxidative organ damage and impaired toxin clearance. To date, the selection of anticoagulants has focused on mechanisms inhibiting white, but not red (erythrocytes) thrombus formation. In the present study, polyethersulfone (PES) membranes were modified with the antioxidant drug tiopronin, the physicochemical properties and dialysis performance of the Tio-PES membranes were evaluated. The effects on erythrocyte thrombosis were evaluated in terms of erythrocyte morphology, prothrombotic properties (adhesion, aggregation, viscosity, sedimentation, and hemolysis), and fibrinogen-erythrocyte interactions...
February 15, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38354834/splanchnic-vein-thrombosis-the-state-of-the-art-on-anticoagulant-treatment
#12
JOURNAL ARTICLE
Scott Custo, Emma Tabone, Alexia Aquilina, Alex Gatt, Nicoletta Riva
Splanchnic vein thrombosis (SVT) is a rare type of venous thromboembolism occurring within the splanchnic venous system. Portal vein thrombosis is the most common presentation, while Budd-Chiari syndrome is the least common. Liver cirrhosis and abdominal solid cancer are the main local risk factors for SVT, whereas myeloproliferative neoplasms are the predominant systemic risk factors. Signs and symptoms of SVT are nonspecific and include abdominal pain, gastrointestinal bleeding, and ascites. Asymptomatic SVT is not uncommon, and the majority would be detected incidentally on routine abdominal imaging performed for the follow-up of liver diseases and tumors...
February 14, 2024: Hämostaseologie
https://read.qxmd.com/read/38341819/treatment-of-hepatocellular-carcinoma-with-a-portal-vein-tumor-thrombus-and-pulmonary-metastases-of-rectal-cancer-with-microsatellite-stability-using-atezolizumab-plus-bevacizumab
#13
JOURNAL ARTICLE
Yoshitaka Inaba, Shohei Chatani, Shinichi Murata, Yozo Sato, Rinpei Imamine, Mina Kato, Hiroaki Onaya, Hidekazu Yamaura
Herein, we report the successful treatment using atezolizumab plus bevacizumab of a patient with hepatocellular carcinoma (HCC) with a portal vein tumor thrombus and multiple pulmonary metastases from rectal cancer with microsatellite stability. This patient developed rectal cancer with synchronous pulmonary metastases and HCC. After resecting the primary lesion of the rectal cancer, transcatheter arterial chemoembolization was performed for the HCC. Drug therapy was planned for multiple pulmonary metastases of rectal cancer; however, the early development of recurrent HCC with portal vein tumor thrombus had to be highly prioritized, and atezolizumab plus bevacizumab was introduced...
February 11, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38311778/selective-aneurysmal-sac-neck-targeted-embolization-during-endovascular-repair-of-abdominal-aortic-aneurysm-with-hostile-neck-anatomy
#14
JOURNAL ARTICLE
Lifeng Zhang, Yongjiang Tang, Jiantao Wang, Xianjun Liu, Yang Liu, Wei Zeng, Chunshui He
PURPOSE: To evaluate the efficacy and safety of selective aneurysmal sac neck-targeted embolization in endovascular aneurysm repair (EVAR) in patients with a hostile neck anatomy (HNA). MATERIALS AND METHODS: Between October 2020 and June 2022, patients with an abdominal aortic aneurysm (AAA) and HNA who underwent EVAR with a low-profile stent graft and a selective aneurysmal sac neck-targeted embolization technique were analysed. An HNA was defined by the presence of any of the following parameters: infrarenal neck angulation > 60°; neck length < 15 mm; conical neck; circumferential calcification ≥ 50%; or thrombus ≥ 50%...
February 4, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38310761/thrombus-migration-in-emergent-m1-middle-cerebral-artery-occlusion
#15
JOURNAL ARTICLE
Slaven Pikija, Monika Killer-Oberpfalzer, Johannes A R Pfaff, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Johannes S Mutzenbach, Daniel Schwarzenhofer, Hecker Constantin
BACKGROUND AND PURPOSE: Thrombus migration (TM) is a well-established phenomenon in patients with intracranial vessel occlusion, particularly in those who receive alteplase. However, the relationship between TM, reperfusion success, and clinic-radiological outcomes is still being determined. This study aimed to describe the various outcomes in the event of TM in patients with M1 middle cerebral artery (M1 MCA) occlusion. MATERIALS AND METHODS: The study involved a retrospective analysis of patients undergoing endovascular thrombectomy (EVT) due to M1 MCA occlusion from two tertiary centers between January 2015 and December 2020...
January 24, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38295745/primary-angiosarcoma-arising-in-the-sinus-of-valsalva-a-case-report
#16
Kenichi Morimoto, Shigeto Miyasaka, Yosuke Ikeda, Rikuto Nii, Yoshikazu Fujiwara
INTRODUCTION: Primary angiosarcoma of the aorta, particularly within the sinus of Valsalva, is uncommon, with no documented instances of primary angiosarcoma. The absence of apparent clinical manifestations in this severe condition makes it challenging to diagnose, often resulting in a poor prognosis. CASE PRESENTATION: A 60-year-old patient underwent procedures for fistula closure and coronary artery bypass grafting, which resulted in the rupture of an aneurysm within the sinus of Valsalva...
January 30, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38285167/flow-affects-the-structural-and-mechanical-properties-of-the-fibrin-network-in-plasma-clots
#17
JOURNAL ARTICLE
Hande Eyisoylu, Emma D Hazekamp, Janneke Cruts, Gijsje H Koenderink, Moniek P M de Maat
The fibrin network is one of the main components of thrombi. Altered fibrin network properties are known to influence the development and progression of thrombotic disorders, at least partly through effects on the mechanical stability of fibrin. Most studies investigating the role of fibrin in thrombus properties prepare clots under static conditions, missing the influence of blood flow which is present in vivo. In this study, plasma clots in the presence and absence of flow were prepared inside a Chandler loop...
January 29, 2024: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/38204165/force-balance-ratio-is-a-robust-predictor-of-arterial-thrombus-stability
#18
JOURNAL ARTICLE
Efim S Berhadsky, Daniel A Ermokhin, Vladimir A Kurattsev, Mikhail A Panteleev, Dmitry Y Nechipurenko
Thrombus formation on a damaged vessel wall can lead to the formation of a stable occlusive/subocclusive clot or unstable embolizing thrombus. Both outcomes can cause significant health damage. The mechanisms that regulate maximum thrombus size, its stability and embolization in both micro- and macrocirculation are poorly understood. To investigate the impact of flow and intrathrombus forces on the stability of homogeneous and heterogeneous platelet thrombi in a wide range of thrombus geometries, critical interplatelet forces, vessel diameters and hydrodynamic conditions, we took advantage of the recently developed in silico models...
January 10, 2024: Biophysical Journal
https://read.qxmd.com/read/38188318/a-case-of-ecpella-supported-treatment-for-post-infarction-cardiac-rupture
#19
Kazuhiro Asano, Masahiko Noguchi, Ryota Hara, Hiroki Sakai, Keita Kikuchi, Joji Ito, Kotaro Obunai, Hiroyuki Watanabe
UNLABELLED: The efficacy and risk of a combination of veno-arterial extracorporeal membrane oxygenation and Impella (Abiomed, Inc., Danvers, MA, USA), an approach known as ECPELLA, for post-infarction cardiac rupture is unclear. We describe the case of a 72-year-old man who presented with acute myocardial infarction. The patient was managed with ECPELLA because of hemodynamic compromise. One week later, there was a sudden increase in venous oxygen saturation. Transthoracic echocardiography revealed ventricular septal rupture, and free wall rupture...
January 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38167880/heparin-network-mediated-long-lasting-coatings-on-intravascular-catheters-for-adaptive-antithrombosis-and-antibacterial-infection
#20
JOURNAL ARTICLE
Lin Liu, Huan Yu, Lei Wang, Dongfang Zhou, Xiaozheng Duan, Xu Zhang, Jinghua Yin, Shifang Luan, Hengchong Shi
Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously...
January 2, 2024: Nature Communications
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