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https://www.readbyqxmd.com/read/28213377/interventional-treatment-of-pulmonary-embolism
#1
David M Dudzinski, Jay Giri, Kenneth Rosenfield
Pulmonary embolism (PE) is a serious and prevalent cause of vascular disease. Nevertheless, optimal treatment for many phenotypes of PE remains uncertain. Treating PE requires appropriate risk stratification as a first step. For the highest-risk PE, presenting as shock or arrest, emergent systemic thrombolysis or embolectomy is reasonable, while for low-risk PE, anticoagulation alone is often chosen. Normotensive patients with PE but with indicia of right heart dysfunction (by biomarkers or imaging) constitute an intermediate-risk group for whom there is controversy on therapeutic strategy...
February 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28101942/the-use-of-hemodynamic-support-in-massive-pulmonary-embolism
#2
Neal Kumar Bhatia, Neal W Dickert, Habib Samady, Vasilis Babaliaros
Massive pulmonary embolism is life threatening and can present as cardiogenic shock and cardiac arrest. We report a case of a 47-year-old male who arrested during his postoperative hospitalization and was found to have a massive pulmonary embolism with bilateral involvement of the pulmonary arteries. Given his profound shock and right ventricular failure, an Impella RP was used to stabilize his acute right ventricular failure while percutaneous embolectomy and thrombolysis was used to treat the pulmonary embolism...
January 19, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27987790/surface-biomimetic-modification-with-laminin-loaded-heparin-poly-l-lysine-nanoparticles-for-improving-the-biocompatibility
#3
Tao Liu, Youdong Hu, Jianying Tan, Shihui Liu, Junying Chen, Xin Guo, Changjiang Pan, Xia Li
Late thrombus and restenosis caused by delayed endothelialization and insufficient biocompatibility of polymer coating continue to be the greatest limitations of drug-eluting stents. In this study, based on the specific structure of vascular basement membrane, a novel biomimetic nano-coating was constructed by incorporating laminin into electrostatic-assembled heparin/poly-l-lysine nanoparticles. Alteration of heparin and poly-l-lysine concentration ratio in a certain range has no significantly influence nanoparticle size, uniformity and stability, but may affect the chemical property and subsequently the binding efficiency to dopamine-coated titanium surface...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27960039/physiologic-and-pathophysiologic-roles-of-interaction-between-c-type-lectin-like-receptor-2-and-podoplanin-partners-from-in-utero-to-adulthood
#4
REVIEW
K Suzuki-Inoue, M Osada, Y Ozaki
A platelet activation receptor, C-type lectin-like receptor 2 (CLEC-2), has been identified as a receptor for a platelet-activating snake venom, rhodocytin. CLEC-2 protein is highly expressed in platelets/megakaryocytes, and at lower levels in liver Kupffer cells. Recently, podoplanin has been revealed as an endogenous ligand for CLEC-2. Podoplanin is expressed in certain types of tumor cells, fibroblastic reticular cells (FRCs) in lymph nodes, kidney podocytes, and lymphatic endothelial cells, but not in vascular endothelial cells...
December 13, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27942000/free-fatty-acids-modulate-thrombin-mediated-fibrin-generation-resulting-in-less-stable-clots
#5
Anna Tanka-Salamon, Erzsébet Komorowicz, László Szabó, Kiril Tenekedjiev, Krasimir Kolev
Upon platelet activation, free fatty acids are released at the stage of thrombus formation, but their effects on fibrin formation are largely unexplored. Our objective was to characterize the kinetic effects of fatty acids on thrombin activity, as well as the structural and mechanical properties of the resultant fibrin clots. Thrombin activity on fibrinogen was followed by turbidimetry and detailed kinetic characterization was performed using a fluorogenic short peptide substrate. The viscoelastic properties of fibrin were measured with rotatory oscillation rheometer, whereas its structure was analyzed with scanning electron microscopy (SEM)...
2016: PloS One
https://www.readbyqxmd.com/read/27909839/biventricular-support-using-a-centrifugal-pump-in-a-6%C3%A2-year-old-with-fulminant-myocarditis
#6
Hiromu Kehara, Tamaki Takano, Takamitsu Terasaki, Kenji Okada
We experienced a case of ventricular assist with both a pulsatile-flow and a continuous-flow pump in a pediatric patient, and herein report the clinical course and characteristics of the pumps. A 6-year-old female was diagnosed with fulminant myocarditis and transferred to our hospital for mechanical support. After 12 days of extracorporeal membrane oxygenation, we implanted a left ventricular assist device (LVAD) and a right ventricular assist device (RVAD) using centrifugal Gyro pumps with a membrane oxygenator in a paracorporeal fashion...
December 1, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27819526/the-effects-of-hydrogen-sulfide-on-platelet-leukocyte-aggregation-and-microvascular-thrombolysis
#7
Eberhard Grambow, Christian Leppin, Katja Leppin, Günther Kundt, Ernst Klar, Marcus Frank, Brigitte Vollmar
The volatile transmitter hydrogen sulfide (H2S) is known for its various functions in vascular biology. This study evaluates the effect of the H2S-donor GYY4137 (GYY) on thrombus stability and microvascular thrombolysis. Human whole blood served for all in vitro studies and was analyzed in a resting state, after stimulation with thrombin-receptor activating peptide (TRAP) and after incubation with 10 or 30 mM GYY or its vehicle DMSO following TRAP-activation, respectively. As a marker for thrombus stability, platelet-leukocyte aggregation was assessed using flow cytometry after staining of human whole blood against CD62P and CD45, respectively...
November 7, 2016: Platelets
https://www.readbyqxmd.com/read/27810245/-severe-pulmonary-embolism-revealed-by-status-epilepticus
#8
N Allou, N Coolen-Allou, B Delmas, C Cordier, J Allyn
INTRODUCTION: High-risk pulmonary embolism (PE) is associated with high mortality rate (>50%). In some cases, diagnosis of PE remains a challenge with atypical presentations like in this case report with a PE revealed by status epilepticus. CASE REPORT: We report the case of a 40-year-old man without prior disease, hospitalized in ICU for status epilepticus. All paraclinical examinations at admission did not show any significant abnormalities (laboratory tests, cardiologic and neurological investigations)...
December 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27780803/emerging-anticoagulant-strategies
#9
James C Fredenburgh, Peter L Gross, Jeffrey I Weitz
Despite the introduction of direct oral anticoagulants (DOACs), the search for more effective and safer antithrombotic strategies continues. Better understanding of the pathogenesis of thrombosis has fostered two new approaches to achieving this goal. First, evidence that thrombin may be as important as platelets to thrombosis at sites of arterial injury and that platelets contribute to venous thrombosis has prompted trials comparing anticoagulants with aspirin for secondary prevention in arterial thrombosis and aspirin with anticoagulants for primary and secondary prevention of venous thrombosis...
October 25, 2016: Blood
https://www.readbyqxmd.com/read/27692635/-is-regression-of-atherosclerotic-plaque-possible
#10
José A Páramo, Fernando Civeira
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion ('angiographic paradox')...
January 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27688592/release-of-experimental-retinal-vein-occlusions-by-direct-intraluminal-injection-of-ocriplasmin
#11
Marc D de Smet, Jean Marie Stassen, Thijs C M Meenink, Tom Janssens, Valérie Vanheukelom, Gerrit J L Naus, Maarten J Beelen, Bart Jonckx
PURPOSE: Retinal vein occlusions (RVO) are a major cause of vision loss in people aged 50 years and older. Current therapeutic options limit the consequences of RVO but do not eliminate the cause. Cannulation of the involved vessel and removal of the clot may provide a more permanent solution with a less demanding follow-up. However, cannulation of smaller retinal veins remains challenging. This paper explores the use of ocriplasmin (recombinant plasmin without its kringles) to clear RVO, using a robotic micromanipulator...
December 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27632423/synthesis-and-biological-evaluation-of-cyclic-99m-tc-hynic-cgprppc-as-a-fibrin-binding-peptide-for-molecular-imaging-of-thrombosis-and-its-comparison-with-99m-tc-hynic-gprpp
#12
Sedigheh Rezaeianpour, Atefeh Hajiagha Bozorgi, Abolghasem Moghimi, Ameneh Almasi, Saeed Balalaie, Sorour Ramezanpour, Sanaz Nasoohi, Seyed Mohammad Mazidi, Parham Geramifar, Ahmad Bitarafan-Rajabi, Soraya Shahhosseini
PURPOSE: Many patients worldwide suffer from cardiovascular diseases for which an underlying factor is thrombosis. Devising a molecular imaging technique for early detection of thrombosis in a clinical setting is highly recommended. Because fibrin is a major constituent of clots and is present in all types of thrombi but absent in circulation, it is a highly specific and sensitive target for molecular imaging of thrombi. It is assumed that cyclization of peptides will improve the receptor binding affinity and stability of the peptide...
September 8, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27608787/acute-myocardial-infarction-in-nephrotic-syndrome
#13
Kavita Krishna, Shirish Hiremath, Sachin Lakade, Sudarshan Davakhar
A 28 year old male, known case of nephrotic syndrome since 12 years, hypertensive presented with acute myocardial infarction (AMI) and accelerated hypertension. Coronary angiography revealed 100% thrombotic occlusion of mid left anterior descending artery, treated with thrombus aspiration and intracoronary tirofiban and nitroglycerine. He was stabilized within 24 hours. The pathogenesis of AMI in nephrotic syndrome has been discussed with this case report.
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27578806/effective-anti-thrombotic-therapy-without-stenting-intravascular-optical-coherence-tomography-based-management-in-plaque-erosion-the-erosion-study
#14
Haibo Jia, Jiannan Dai, Jingbo Hou, Lei Xing, Lijia Ma, Huimin Liu, Maoen Xu, Yuan Yao, Sining Hu, Erika Yamamoto, Hang Lee, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
AIMS: Plaque erosion, compared with plaque rupture, has distinctly different underlying pathology and therefore may merit tailored therapy. In this study, we aimed to assess whether patients with acute coronary syndrome (ACS) caused by plaque erosion might be stabilized by anti-thrombotic therapy without stent implantation. METHODS AND RESULTS: This was a single-centre, uncontrolled, prospective, proof-of concept study. Patients with ACS including ST-segment elevation myocardial infarction were prospectively enrolled...
August 30, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27574455/meta-analysis-of-the-prognostic-value-of-abnormally-expressed-lncrnas-in-hepatocellular-carcinoma
#15
Zhen Qu, Chun-Hui Yuan, Chang-Qing Yin, Qing Guan, Hao Chen, Fu-Bing Wang
Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in hepatocellular carcinoma (HCC), and may have the potential to serve as prognostic markers. In this study, a meta-analysis was conducted to systematically evaluate the prognostic value of various lncRNAs in HCC. Eligible literatures were systematically collected from PubMed, Embase, Web of Science, and Cochrane Library (up to December 30, 2015). The main outcomes including overall survival, relapse-free survival, and disease-free survival were analyzed...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27555152/cardiac-arrest-during-radical-nephrectomy-due-to-a-mass-in-the-right-ventricular-outflow-tract
#16
Hee Young Kim, Seung-Hoon Baek, Ji Uk Yoon, Dong Hoon Lee, Gyeong-Jo Byeon, Ji Hye Ahn
We report cardiac arrest due to obstruction of the right ventricular outflow tract (RVOT) caused by an RVOT mass that was not identified preoperatively. A 62-year-old woman with renal cell carcinoma (RCC) experienced deteriorating hypotension and bradycardia during radical nephrectomy. Hemodynamic stability was maintained on extracorporeal membrane oxygenation, and after surgery, she was transferred to the intensive care unit. On postoperative day 3, transthoracic echocardiography showed an intracardiac mass obstructing the RVOT, which caused severe functional pulmonary stenosis and moderate resting pulmonary hypertension...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27530412/endovascular-stent-grafting-of-the-ascending-aorta-for-symptomatic-parietal-thrombus
#17
Andrea Kahlberg, Matteo Montorfano, Tommaso Cambiaghi, Luca Bertoglio, Germano Melissano, Roberto Chiesa
PURPOSE: To present stent-graft treatment of parietal thrombus in the ascending aorta. CASE REPORT: A 64-year-old man with no history of vascular disease developed a right cerebral hemisphere transient ischemic attack and was diagnosed with mural thrombosis of the ascending aorta involving the greater curvature just proximal to the origin of the innominate artery. He was treated for 2 months with anticoagulants, but new imaging studies showed significant increase in the size of the thrombus and an irregular aspect...
August 16, 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27494773/the-tyrosine-kinase-inhibitor-nilotinib-potentiates-a-prothrombotic-state
#18
Naif Alhawiti, Kate L Burbury, Faith A Kwa, Cindy J O'Malley, Peter Shuttleworth, Mohamad Alzard, Abdullah Hamadi, Andrew P Grigg, Denise E Jackson
Tyrosine kinase inhibitors (TKI) such as imatinib, nilotinib and dasatinib are now established as highly effective frontline therapies for chronic myeloid leukaemia (CML). Disease control is achieved in the majority of patients and survival is excellent such that recent focus has been on toxicities of these agents. Cumulative data have reported an excess of serious vascular complications, including arterial thrombosis and peripheral arterial occlusive disease, in patients receiving nilotinib in comparison with other TKIs, with resultant interest in delineating the pathophysiology and implications for rationale cardiovascular risk modification...
September 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27458520/modification-of-shape-memory-polymer-foams-using-tungsten-aluminum-oxide-and-silicon-dioxide-nanoparticles
#19
S M Hasan, R S Thompson, H Emery, A L Nathan, A C Weems, F Zhou, M B B Monroe, D J Maitland
Shape memory polymer (SMP) foams were synthesized with three different nanoparticles (tungsten, silicon dioxide, and aluminum oxide) for embolization of cerebral aneurysms. Ultra-low density SMP foams have previously been utilized for aneurysm occlusion, resulting in a rapid, stable thrombus. However, the small cross section of foam struts can potentially lead to fracture and particulate generation, which would be a serious adverse event for an embolic device. The goal of this study was to improve the mechanical properties of the system by physically incorporating fillers into the SMP matrix...
2016: RSC Advances
https://www.readbyqxmd.com/read/27351623/primary-pleomorphic-liposarcoma-of-the-spine-case-report-and-review-of-the-literature
#20
A M Morales-Codina, J A Martín-Benlloch, M Corbellas Aparicio
INTRODUCTION: To describe a single case, the fourth ever reported, of pleomorphic liposarcoma of the spine and to undertake a review of the literature. PRESENTATION OF CASE: A 60 year old male patient had a bilateral lumbosciatica over a 3 month period. Imaging tests revealed a tumor mass in L1-L3 and a fracture in L2. Also, he had a mural thrombus both in the inferior vena cava and the left renal vein. The biopsy revealed a well-differentiated liposarcoma. En bloc resection of the lesion and stabilization was carried out...
2016: International Journal of Surgery Case Reports
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