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https://www.readbyqxmd.com/read/28077190/measures-of-the-dsm-5-mixed-features-specifier-of-major-depressive-disorder
#1
Mark Zimmerman
During the past two decades, a number of studies have found that depressed patients frequently have manic symptoms intermixed with depressive symptoms. While the frequency of mixed syndromes are more common in bipolar than in unipolar depressives, mixed states are also common in patients with major depressive disorder. The admixture of symptoms may be evident when depressed patients present for treatment, or they may emerge during ongoing treatment. In some patients, treatment with antidepressant medication might precipitate the emergence of mixed states...
January 12, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28073041/major-depressive-disorder-with-subthreshold-hypomanic-mixed-features-a-real-world-assessment-of-treatment-patterns-and-economic-burden
#2
Roger S McIntyre, Daisy Ng-Mak, Chien-Chia Chuang, Rachel Halpern, Pankaj A Patel, Krithika Rajagopalan, Antony Loebel
BACKGROUND: To compare outcomes for individuals with major depressive disorder (MDD) with or without subthreshold hypomania (mixed features) in naturalistic settings. METHODS: Using the Optum Research Database (1/1/2009─10/31/2014), a retrospective analysis of individuals newly diagnosed with MDD was conducted. Continuous enrollment for 12-months before and after the initial MDD diagnosis was required. MDD with subthreshold hypomania (mixed features) (MDD-MF) was defined based on ≥1 hypomania diagnosis within 30 days after an MDD diagnosis during the one-year follow-up period, in the absence of bipolar I diagnoses...
December 23, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28066004/prevalence-of-psychiatric-morbidity-among-cancer-patients-hospital-based-cross-sectional-survey
#3
Mohan Roy Gopalan, Vidhukumar Karunakaran, Anil Prabhakaran, Krishnannair Lalithamma Jayakumar
AIM: To study the prevalence of Psychiatric disorders in cancer patients and to find out the factors associated with Psychiatric disorders in Cancer Patients. SETTINGS AND DESIGN: Department of Radiotherapy, Medical College, Thiruvananthapuram, cross sectional survey design was used. METHODS AND MATERIAL: Adult patients (18 years of age and above), having a diagnosis of carcinoma were selected by consecutive sampling method.A questionnaire which included back ground data, socio economic variables, treatment variables like type of malignancy, exposure to radiation & chemotherapy prior to the evaluation and current treatment, co occurring medical illness & treatment and past & family history of psychiatric illness was used to collect data...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28012610/secondary-to-excessive-melatonin-synthesis-the-consumption-of-tryptophan-from-outside-the-blood-brain-barrier-and-melatonin-over-signaling-in-the-pars-tuberalis-may-be-central-to-the-pathophysiology-of-winter-depression
#4
José Carlos Pereira, Márcia Pradella Hallinan, Rosana Cardoso Alves
Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter depression repeatedly occurs in the autumn or winter and remits in the spring or summer, and its etiopathogenesis is currently unknown. However, one can surmise that excessive melatonin production during the reduced duration of daily sunlight in the autumn and winter plays a role in its pathophysiology...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28004626/treating-mixed-mania-hypomania-a-review-and-synthesis-of-the-evidence
#5
Minoru Takeshima
The DSM-5 incorporates a broad concept of mixed states and captured ≥3 nonoverlapping symptoms of the opposite polarity using a "with mixed features" specifier to be applied to manic/hypomanic and major depressive episodes. Pharmacotherapy of mixed states is challenging because of the necessity to treat both manic/hypomanic and depressive symptoms concurrently. High-potency antipsychotics used to treat manic symptoms and antidepressants can potentially deteriorate symptoms of the opposite polarity. This review aimed to provide a synthesis of the current evidence for pharmacotherapy of mixed states with an emphasis on mixed mania/hypomania...
December 22, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28002572/activation-in-bipolar-disorders-a-systematic-review
#6
Jan Scott, Greg Murray, Chantal Henry, Gunnar Morken, Elizabeth Scott, Jules Angst, Kathleen R Merikangas, Ian B Hickie
Importance: Increased activity and energy alongside mood change are identified in the DSM-5 as cardinal symptoms of mania and hypomania. A wide range of existing research suggests that this revision may be valid, but systematic integration of the evidence has not been reported. The term activation is understood as emerging from underlying physiological change and having objective (observable motor activity) and related subjective (energy) levels. Objectives: To systematically review studies of the clinical phenomenon of activation in bipolar disorder, to determine whether activation is statistically abnormal in bipolar disorder and demonstrably distinct from mood, and to identify any significant between- and within-individual differences in the dynamics of activation...
December 21, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27987053/protection-against-hormone-mediated-mood-symptoms
#7
Leah C Susser, Alison D Hermann
We present the case of a woman with bipolar I disorder with severe premenstrual mood instability, confusion, and psychosis resembling the clinical features of postpartum psychosis when estrogen levels are expected to be low, and hypomania when estrogen levels are expected to be elevated. While depressive symptoms across the menstrual cycle have been extensively documented in the literature, there is little information regarding manic and hypomanic symptoms. In addition, we describe the successful treatment of her menstrual-cycle related symptoms...
December 16, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27916405/treatment-emergent-mania-hypomania-during-antidepressant-treatment-with-transcranial-direct-current-stimulation-tdcs-a-systematic-review-and-meta-analysis
#8
André R Brunoni, Adriano H Moffa, Bernardo Sampaio-Júnior, Verònica Gálvez, Colleen K Loo
BACKGROUND: Treatment-emergent mania/hypomania (TEM) is a possible adverse effect of pharmacological and non-pharmacological antidepressant treatments. OBJECTIVE: We performed a systematic review and meta-analysis to evaluate the risk of TEM in depressed patients during randomized, sham-controlled trials (RCTs). DATA SOURCES: Medline database, from the first date available to August 12, 2016. RESULTS: From 283 references, 10 RCTs were identified...
November 14, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27862615/the-reciprocal-relationship-between-bipolar-disorder-and-social-interaction-a-qualitative-investigation
#9
Rebecca Owen, Patricia Gooding, Robert Dempsey, Steven Jones
BACKGROUND: Evidence suggests that social support can influence relapse rates, functioning and various clinical outcomes in people with bipolar disorder. Yet 'social support' is a poorly defined construct, and the mechanisms by which it affects illness course in bipolar disorder remain largely unknown. Key aims of this study were to ascertain which facets of social interaction affect mood management in bipolar disorder, and how symptoms of bipolar disorder can influence the level of support received...
November 13, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27822021/time-to-lack-of-persistence-with-pharmacological-treatment-among-patients-with-current-depressive-episodes-a-natural-study-with-1-year-follow-up
#10
Kanglai Li, Qinling Wei, Guanying Li, Xiangjun He, Yingtao Liao, Zhaoyu Gan
INTRODUCTION: Medication nonadherence remains a big challenge for depressive patients. This study aims to assess and compare the medication persistence between unipolar depression (UD) and bipolar depression (BD). METHODS: A total of 146 UD and 187 BD patients were recruited at their first index prescription. Time to lack of persistence with pharmacological treatment (defined as a gap of at least 60 days without taking any medication) was calculated, and clinical characteristics were collected...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27816074/role-of-reward-sensitivity-and-processing-in-major-depressive-and-bipolar-spectrum-disorders
#11
Lauren B Alloy, Thomas Olino, Rachel D Freed, Robin Nusslock
Since Costello's (1972) seminal Behavior Therapy article on loss of reinforcers or reinforcer effectiveness in depression, the role of reward sensitivity and processing in both depression and bipolar disorder has become a central area of investigation. In this article, we review the evidence for a model of reward sensitivity in mood disorders, with unipolar depression characterized by reward hyposensitivity and bipolar disorders by reward hypersensitivity. We address whether aberrant reward sensitivity and processing are correlates of, mood-independent traits of, vulnerabilities for, and/or predictors of the course of depression and bipolar spectrum disorders, covering evidence from self-report, behavioral, neurophysiological, and neural levels of analysis...
September 2016: Behavior Therapy
https://www.readbyqxmd.com/read/27810616/exposure-to-tobacco-smoke-in-utero-or-during-early-childhood-and-risk-of-hypomania-prospective-birth-cohort-study
#12
D F Mackay, J J Anderson, J P Pell, S Zammit, D J Smith
OBJECTIVES: Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood. METHODS: We used data on 2957 participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was "hypomania plus previous psychotic experiences (PE)"...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27769005/a-genome-wide-association-study-suggests-the-association-of-muskelin-with-early-onset-bipolar-disorder-implications-for-a-gabaergic-epileptogenic-neurogenesis-model
#13
Malik Nassan, Qingqin Li, Paul E Croarkin, Wenan Chen, Colin L Colby, Marin Veldic, Susan L McElroy, Gregory D Jenkins, Euijung Ryu, Julie M Cunningham, Marion Leboyer, Mark A Frye, Joanna M Biernacka
BACKGROUND: Although multiple genes have been implicated in bipolar disorder (BD), they explain only a small proportion of its heritability. Identifying additional BD risk variants may be impaired by phenotypic heterogeneity, which is usually not taken into account in genome-wide association studies (GWAS). BD with early age at onset is a more homogeneous familial form of the disorder associated with greater symptom severity. METHODS: We conducted a GWAS of early-onset BD (onset of mania/hypomania ≤19 years old) in a discovery sample of 419 cases and 1034 controls and a replication sample of 181 cases and 777 controls...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27735894/-mental-disorders-in-patients-with-acromegaly
#14
A E Bobrov, E G Starostina, M M Aleksandrova
AIM: To study mental disorders in acromegaly due to somatotropinoma. MATERIAL AND METHODS: The study included 115 consecutively recruited patients with acromegaly (95 female and 20 male, aged from 21 to 78 years). Acromegaly was diagnosed by endocrinologists according to current guidelines based on clinical, laboratory data and brain MRI. All patients underwent a clinical psychiatric interview based on ICD-10 criteria. The Mini-Mental State Examination scale and Hypomania-Checklist (HCL-32) were used...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27728870/characterization-and-structure-of-hypomania-in-a-british-nonclinical-adolescent-sample
#15
Georgina M Hosang, Alastair G Cardno, Daniel Freeman, Angelica Ronald
BACKGROUND: This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential importance for early intervention policy development. METHOD: To explore the structure and characterization of hypomania in a British adolescent nonclinical cohort, over 1400 17 year olds (Mean=17...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27727432/s-adenosyl-methionine-same-for-depression-in-adults
#16
REVIEW
Ilaria Galizia, Lucio Oldani, Karine Macritchie, Erica Amari, Dominic Dougall, Tessa N Jones, Raymond W Lam, Guido Jacopo Massei, Lakshmi N Yatham, Allan H Young
BACKGROUND: Depression is a recurrent illness with high rates of chronicity, treatment-resistance and significant economic impact. There is evidence in the literature that S-adenosyl methionine (SAMe), a naturally occurring compound in the human body, has antidepressant efficacy. This product may be an important addition to the armamentarium of antidepressant agents. OBJECTIVES: To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults...
October 10, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27632572/screening-mixed-depression-and-bipolarity-in-the-postpartum-period-at-a-primary-health-care-center
#17
Sercan Bulut Çelik, Gamze Erten Bucaktepe, Ayşegül Uludağ, İbrahim Umud Bulut, Özgür Erdem, Kürşat Altınbaş
INTRODUCTION: Mixed depression is a clinical condition accompanied by the symptoms of (hypo)mania and is considered to be a predictor for bipolar disorder. Compared to pure major depression, mixed depression is worse in progress. There are limited data on the prevalence of mixed depression since it is a relatively new entity. Therefore, the present study aimed to investigate the prevalence of mixed depression during the postpartum period which is risky for mood disorders. METHODS: The study included 63 postpartum women...
August 4, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27631140/omega-3-and-omega-6-polyunsaturated-fatty-acids-in-bipolar-disorder-a-review-of-biomarker-and-treatment-studies
#18
REVIEW
Erika F H Saunders, Christopher E Ramsden, Mostafa S Sherazy, Alan J Gelenberg, John M Davis, Stanley I Rapoport
OBJECTIVE: There is growing evidence that inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the data on PUFAs as biomarkers in bipolar disorder and n-3 PUFA used as treatment for bipolar disorder. DATA SOURCES: PubMed and CINAHL were searched for articles on PUFA and bipolar disorder published in the English language through November 6, 2013, with an updated search conducted on August 20, 2015...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27536109/post-stroke-emotional-incontinence-or-bipolar-disorder
#19
Leila Mnif, Rim Sellami, Jawaher Masmoudi
INTRODUCTION: Post-stroke emotional incontinence and bipolar disorder are two disorders that involve the dysfunction of brain structures responsible for emotional regulation. The objective of this work is to study the links between these disorders through a clinical case. CASE REPORT: We present the case of a 43-year-old man without previous psychiatric history who experienced emotional incontinence after cerebrovascular events. He reacted promptly to selective serotonin reuptake inhibitor treatment...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27523498/increased-activity-or-energy-as-a-primary-criterion-for-the-diagnosis-of-bipolar-mania-in-dsm-5-findings-from-the-step-bd-study
#20
Rodrigo Machado-Vieira, David A Luckenbaugh, Elizabeth D Ballard, Ioline D Henter, Mauricio Tohen, Trisha Suppes, Carlos A Zarate
OBJECTIVE: DSM-5 describes "a distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy" as a primary criterion for mania. Thus, increased energy or activity is now considered a core symptom of manic and hypomanic episodes. Using data from the Systematic Treatment Enhancement Program for Bipolar Disorder study, the authors analyzed point prevalence data obtained at the initial visit to assess the diagnostic validity of this new DSM-5 criterion...
January 1, 2017: American Journal of Psychiatry
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