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Anti-mullerian hormone

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https://www.readbyqxmd.com/read/28531375/mouse-minipuberty-coincides-with-gonocyte-transformation-into-spermatogonial-stem-cells-a-model-for-human-minipuberty
#1
Ruili Li, Amanda Vannitamby, Sarah S K Yue, David Handelsman, John Hutson
As the transient postnatal hormone surge in humans, known as 'minipuberty', occurs simultaneously with key steps in germ-cell development, we investigated whether similar changes occur in the hypothalamic-pituitary-testicular axis of neonatal mice at a time that would coincide with gonocyte transformation into spermatogonial stem cells (SSC). Serum and testes were collected from C57Bl/6 mice at embryonic Day 17 (E17), birth (postnatal Day 0; P0) and daily until P10. Serum FSH and testosterone levels in both serum and testes were analysed and gene expression of FSH receptor (Fshr), luteinising hormone receptor (Lhr), anti-Müllerian hormone (Amh), octamer-binding transcription factor 4 (Oct-4), membrane type 1 metalloprotease (Mt1-mmp), proto-oncogene C-kit and promyelocytic leukaemia zinc finger (Plzf ) was quantified by real-time polymerase chain reaction...
May 23, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#2
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
May 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28528332/the-persistent-m%C3%A3-llerian-duct-syndrome-an-update-based-upon-a-personal-experience-of-157-cases
#3
Jean-Yves Picard, Richard L Cate, Chrystèle Racine, Nathalie Josso
Male sex differentiation is driven by 2 hormones, testosterone and anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses. Mutations inactivating AMH or its receptor AMHRII lead to the persistent müllerian duct syndrome (PMDS) in otherwise normally virilized 46,XY males. Our objective was to review the clinical, anatomical, and molecular features of PMDS based upon a review of the literature and upon 157 personal cases. Three clinical presentations exist: bilateral cryptorchidism, unilateral cryptorchidism with contralateral hernia, and transverse testicular ectopia...
May 20, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28523256/ovarian-volume-in-korean-women-with-polycystic-ovary-syndrome-and-its-related-factors
#4
Young Shin Han, Ah Rha Lee, Hee Kyoung Song, Jeong In Choi, Jang Heub Kim, Mee Ran Kim, Min Jeong Kim
OBJECTIVES: The aim of this study was to determine the relationship of ovarian volume (OV) to age, height, and weight in Korean young women with the polycystic ovary syndrome (PCOS) undergoing ultrasonography (US) and to investigate the relationship between ovarian follicle count and volume on US and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin. METHODS: A total of 272 Korean nulliparous women aged 15 to 39 years who were newly diagnosed with PCOS at a university hospital were included in this study...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28505284/pathogenic-anti-m%C3%A3-llerian-hormone-variants-in-polycystic-ovary-syndrome
#5
Lidija K Gorsic, Gulum Kosova, Brian Werstein, Ryan Sisk, Richard S Legro, M Geoffrey Hayes, Jose M Teixeira, Andrea Dunaif, Margrit Urbanek
CONTEXT: Polycystic ovary syndrome (PCOS), a common endocrine condition, is the leading cause of anovulatory infertility. OBJECTIVE: Given that common disease-susceptibility variants account for only a small percentage of the estimated PCOS heritability, we tested the hypothesis that rare variants contribute to this deficit in heritability. DESIGN, SETTING, AND PARTICIPANTS: Unbiased whole genome sequencing (WGS) of 80 PCOS cases and 24 reproductively normal control women identified potentially deleterious variants in AMH, the gene encoding anti-Müllerian hormone (AMH)...
May 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28500669/anti-m%C3%A3-llerian-hormone-signalling-is-influenced-by-follistatin-288-but-not-fourteen-other-transforming-growth-factor-beta-superfamily-regulators
#6
Yui Kawagishi, Michael W Pankhurst, Yoshio Nakatani, Ian S McLennan
The hypothesis that, in contrast to other Transforming growth factor-beta (TGFβ) superfamily ligands, the dose-response curve of Anti-Müllerian hormone (AMH) is unmodulated was tested by examining whether known TGFB superfamily modulators affect AMH signalling, using a P19/BRE luciferase reporter assay. AMHC and AMHN,C activated the reporter with an EC50 of approximately 0.5 nM. Follistatins (FS) produced concentration-dependent increases in AMHC - and AMHN,C -inidiated reporter activity, with FS288 being more potent than FS315; however, the maximum bioactivity of AMH was not altered by either follistatin...
May 13, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28487028/insl3-and-amh-in-patients-with-previously-congenital-or-acquired-undescended-testes
#7
Jocelyn van Brakel, Sabine M P F de Muinck Keizer-Schrama, Frans W J Hazebroek, Gert R Dohle, Frank H de Jong
BACKGROUND: In previous reports no differences in Leydig and Sertoli cell function were found between congenital undescended testis (CUDT) and acquired UDT (AUDT) on the basis of serum levels of LH, testosterone, FSH or inhibin B. This study tried to detect differences in Leydig and Sertoli cell function between CUDT and AUDT using insulin-like peptide 3 (INSL3) and anti-Müllerian hormone (AMH). METHOD: 118 men with a history of UDT (CUDT N=55 (6/55 bilateral), AUDT N=63 (15/63 bilateral)) were investigated...
April 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28479753/the-effect-of-metformin-and-cinnamon-on-serum-anti-mullerian-hormone-in-women-having-pcos-a-double-blind-randomized-controlled-trial
#8
Budi Wiweko, Cynthia A Susanto
BACKGROUND: Polycystic ovary syndrome (PCOS) is known to be associated with insulin resistance and anti-Mullerian hormone (AMH), leading to the use of insulin-sensitizing agents (ISAs) to manage PCOS. Metformin is the most widely used ISA to treat irregular menstruation; however, the gastrointestinal side effects are quite debilitating. The development of herbal medicines such as bioactive fraction DLBS3233 offers a possibly effective treatment with minimal side effects. AIM: To determine the effect of metformin and DLBS3233 on serum AMH level...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28479752/is-amh-level-independent-of-age-a-predictor-of-live-birth-in-ivf
#9
Mohar Goswami, Dimitrios Nikolaou
BACKGROUND: Although anti-mullerian hormone (AMH) level is known to predict ovarian reserve, there is conflicting evidence regarding the association between AMH and clinical pregnancy or live birth (LB). AIM: Our aim is to establish if there is any association between AMH and LB considering the effects of age and other relevant confounding factors in predicting LB. SETTINGS AND DESIGN: 200 in-vitro fertilisation (IVF) cycles were retrospectively analysed in a tertiary fertility centre...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28471535/ovarian-reserve-after-salpingectomy-a-systematic-review-and-meta-analysis
#10
REVIEW
Ahmed Aboelfadle Mohamed, Ali Haroun Yosef, Cathryn James, Tarek Khalaf Al-Hussaini, Mohamed Ali Bedaiwy, Saad Ali K S Amer
INTRODUCTION: Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. MATERIAL AND METHODS: A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered...
March 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28469767/melatonin-protects-premature-ovarian-insufficiency-induced-by-tripterygium-glycosides-role-of-sirt1
#11
Min Ma, Xiu-Ying Chen, Bin Li, Xiao-Tian Li
Melatonin confers protective effects on premature ovarian insufficiency (POI) induced by tripterygium glycosides (TG) by reducing oxidative stress. Silent information regulator 1 (SIRT1) signaling is found to be associated with the physiology and pathology of ovary. We hypothesize that melatonin could protect POI via activating SIRT1 signaling. The aim of this study was to investigate the protective effect of melatonin on POI and elucidate its potential mechanisms. Mice were assigned to melatonin treatment with or without SIRT1 inhibitor Ex527 or melatonin receptor antagonist luzindole (Luz) and then subjected to POI...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28463758/prospective-evaluation-of-serum-anti-m%C3%A3-llerian-hormone-dynamics-in-250-women-of-reproductive-age-treated-with-chemotherapy-for-breast-cancer
#12
A Dezellus, P Barriere, M Campone, C Lemanski, L Vanlemmens, L Mignot, T Delozier, C Levy, C Bendavid, M Debled, T Bachelot, C Jouannaud, C Loustalot, M A Mouret-Reynier, A Gallais-Umbert, D Masson, T Freour
AIM: Women of reproductive age with breast cancer generally receive gonadotoxic chemotherapy. Fertility issues are of great concern for them. However, little is known on ovarian damage during chemotherapy and its evolution during long-term follow-up. The aim of this study was to provide a detailed description of serum anti-Müllerian hormone (AMH) evolution during chemotherapy and 24-month follow-up. METHODS: This prospective cohort study was conducted in 250 patients, aged 18-39 years, diagnosed with breast cancer and treated with adjuvant/neoadjuvant chemotherapy...
April 29, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28460567/human-mesenchymal-stem-cells-partially-reverse-infertility-in-chemotherapy-induced-ovarian-failure
#13
Sara A Mohamed, Shahinaz M Shalaby, Mohamed Abdelaziz, Soumia Brakta, William D Hill, Nahed Ismail, Ayman Al-Hendy
INTRODUCTION: Chemotherapy is the most commonly used modality to treat human cancers; however, in many cases it causes irreversible ovarian failure. In this work, we plan to evaluate the restorative function of human bone marrow mesenchymal stem cells (BMSCs) in a chemotherapy-induced ovarian failure mouse model. METHODS: Acclimatized 4 to 6 week-old female mice (C57BL/6) were assigned randomly to a vehicle-treated control group (group 1), chemotherapy-treated group followed by vehicle alone (group 2), or chemotherapy-treated group followed by stem cell intraovarian injection (group 3)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28457181/new-amh-assay-allows-rapid-point-of-care-measurements-of-ovarian-reserve
#14
Ewa Pastuszek, Aron Lukaszuk, Michal Kunicki, Joanna Mockun, Grzegorz Kloss, Iwona Malinowska, Adam Czyzyk, Blazej Meczekalski, Krzysztof Lukaszuk
In this study, we compare two commercial automated immunoassays used to evaluate serum anti-Müllerian hormone (AMH) levels as a prognostic value for ovarian response and pregnancy outcome in assisted reproductive technology cycles. Serum AMH was measured for 193 women. We performed a simultaneous measurement in serum AMH with the two alternative kits VIDAS® and Elecsys® AMH assay. For all women undergoing in vitro fertilization cycle, we collected data on their antral follicle count (AFC) and numbers of retrieved cumulus oocyte complexes (OC) and metaphase II oocytes and pregnancy outcome...
May 1, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28454580/association-of-skewed-x-chromosome-inactivation-with-fmr1-cgg-repeat-length-and-anti-mullerian-hormone-levels-a-cohort-study
#15
David H Barad, Sarah Darmon, Andrea Weghofer, Gary J Latham, Filipovic-Sadic, Qi Wang, Vitaly A Kushnir, David F Albertini, Norbert Gleicher
BACKGROUND: Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, if so, is also associated with age adjusted antimüllerian hormone (AMH) levels as an indicator of functional ovarian reserve (FOR). METHODS: DNA samples of 58 women were analyzed for methylation status and confirmation of CGGn repeat length...
April 28, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28454499/phenotypic-variation-in-anti-mullerian-hormone-amh-production-per-follicle-in-women-with-polycystic-ovary-syndrome-pcos-and-isolated-polycystic-ovarian-morphology-pcom-an-observational-cross-sectional-study
#16
Priya Bhide, Abhijit Kulkarni, Merve Dilgil, Puja Dhir, Amit Shah, Anil Gudi, Roy Homburg
This observational study compares the ratio of serum anti-Mullerian hormone (AMH) to the total antral follicle count (AFC) (as a marker of AMH production per follicle) in the various phenotypes of women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM). Two hundred and sixty-two women were recruited. Women with PCOS were divided into four phenotypes based on the diagnostic inclusion criteria of oligo-anovulation (OA), hyperandrogenism (HA) and polycystic ovarian morphology (PCOM)...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28454495/prediction-value-of-anti-mullerian-hormone-amh-serum-levels-and-antral-follicle-count-afc-in-hormonal-contraceptive-hc-users-and-non-hc-users-undergoing-ivf-pgd-treatment
#17
Maayan Bas-Lando, Ron Rabinowitz, Rivka Farkash, Nurit Algur, Esther Rubinstein, Oshrat Schonberger, Talia Eldar-Geva
Use of hormone contraceptives (HC) is very popular in the reproductive age and, therefore, evaluation of ovarian reserve would be a useful tool to accurately evaluate the reproductive potential in HC users. We conducted a retrospective cohort study of 41 HC users compared to 57 non-HC users undergoing IVF-preimplantation genetic diagnosis (PGD) aiming to evaluate the effect of HC on the levels of anti-Mullerian hormone (AMH), small (2-5 mm), large (6-10 mm) and total antral follicle count (AFC) and the ability of these markers to predict IVF outcome...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28450646/effect-of-mitotane-on-mouse-ovarian-follicle-development-and-fertility
#18
Federica Innocenti, Lidia Cerquetti, Serena Pezzilli, Barbara Bucci, Vincenzo Toscano, Rita Canipari, Antonio Stigliano
Mitotane (MTT) is an adrenolytic drug used in advanced and adjuvant treatment of adrenocortical carcinoma, in Cushing's disease and in ectopic syndrome. However, knowledge about its effects on the ovary is still scarce. The purpose of this study is to investigate the effect of MTT on the ovary using in vivo and in vitro models. The study was performed in CD1 mice and in the COV-434 human ovarian granulosa cell line. We examined ovarian morphology, follicle development, steroidogenesis and procreative function in mice and the effect of MTT on cell growth in vitro...
April 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28447513/clinical-utility-of-different-anti-m%C3%A3-llerian-hormone-amh-assays-for-the-purpose-of-pregnancy-prediction
#19
Joanna Liss, Michal Kunicki, Adam Czyzyk, Ewa Pastuszek, Judyta Zabielska, Blazej Meczekalski, Krzysztof Lukaszuk
PURPOSE: Comparison of outcomes of IVF cycles where the AMH levels was measured with five different AMH kits: Immunotech (IOT), Beckman Coulter II Gen. RUO, Beckman Coulter II Gen. IVD (BC II IVD), Ansh Labs ultrasensitive (Ansh) and the automated Elecsys Roche assay. METHODS: Retrospective analysis of clinical data for 3693 cycles. RESULTS: In women < 35 years with low (<0.6 ng/ml) and high (>1.4 ng/ml) AMH concentrations, and in those > 39 years with medium (≥0...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28445964/abo-blood-group-and-ovarian-reserve-a-meta-analysis-and-systematic-review
#20
Jie Deng, Mengmeng Jia, Xiaolin Cheng, Zhen Yan, Dongmei Fan, Xiaoyu Tian
Ovarian reserve reflects a woman's fertility potential. The ABO blood group system is a very stable genetic marker. Although many recent studies have explored the relationship between ABO blood group and ovarian reserve, a consensus has not yet been reached. This paper is the first meta-analysis and systematic review of the relationship between ABO blood type and ovarian reserve. We analyzed seven cross-sectional studies evaluating follicle stimulating hormone (FSH) or anti-Mullerian hormone (AMH) levels in 55,113 participants to determine ovarian reserve...
April 11, 2017: Oncotarget
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