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Anti-mullerian hormone

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https://www.readbyqxmd.com/read/29663637/reproductive-health-obesity-and-cardiometabolic-risk-factors-among-samoan-women
#1
H Maredia, N L Hawley, G Lambert-Messerlian, U Fidow, M S Reupena, T Naseri, S T McGarvey
OBJECTIVES: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. METHODS: A cross-sectional sample of Samoan women 25-39 years of age (n = 470) from a larger population-based genome-wide association study of adiposity and cardiometabolic disease was assessed for the prevalence of oligomenorrhea/amenorrhea (OM/AM) using a self-reported questionnaire...
April 16, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29662823/the-likelihood-of-achieving-pregnancy-through-timed-coitus-in-young-infertile-women-with-decreased-ovarian-reserve
#2
Hwa Seon Koo, In Ok Song, Sun Hwa Cha, Chan Woo Park, Hye Ok Kim
Objective: To evaluate the pregnancy rate and time to pregnancy after timed coitus with or without superovulation in infertile young women younger than 35 years old with low serum anti-Müllerian hormone (AMH) levels (<25th percentile). Methods: A total of 202 patients younger than 35 years old were recruited retrospectively between 2010 and 2012. Ninety-eight women had normal serum AMH levels (25-75th percentile), 75 women had low serum AMH levels (5th≤&<25th percentile) and 29 women had very low serum AMH levels (<5th percentile), according to reference values for their age group...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29662617/premature-ovarian-aging-in-brca-carriers-a-prototype-of-systemic-precocious-aging
#3
Irit Ben-Aharon, Mattan Levi, David Margel, Rinat Yerushalmi, Shulamith Rizel, Shlomit Perry, Eran Sharon, Noa Hasky, Ronit Abir, Benny Fisch, Ana Tobar, Ruth Shalgi, Salomon Marcello Stemmer
Purpose: Though former evidence implies a correlation of breast cancer susceptibility gene ( BRCA ) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort of young healthy carriers of the BRCA mutation. We hypothesized that the role played by BRCA genes in aging pathways is not exclusive to the ovary. Experimental Design: Healthy female BRCA carriers, 40 years or younger and healthy male BRCA carriers, 50 years or younger, were enrolled in the study...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29659835/anti-m%C3%A3-llerian-hormone-levels-and-incidence-of-early-natural-menopause-in-a-prospective-study
#4
Elizabeth R Bertone-Johnson, JoAnn E Manson, Alexandra C Purdue-Smithe, Anne Z Steiner, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Brian W Whitcomb
STUDY QUESTION: Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER: We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY: The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29652213/ovarian-reserve-in-young-juvenile-idiopathic-arthritis-patients
#5
Gabriela R V Ferreira, Renato B Tomioka, Nadia E Aikawa, Elaine P Leon, Gustavo A R Maciel, Paulo C Serafini, Edmund C Baracat, Claudia Goldenstein-Schainberg, Rosa M R Pereira, Eloisa Bonfá, Clovis A Silva
OBJECTIVES: Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are not systematic data regarding ovarian function in this disease. METHODS: Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL)...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29649968/swimming-exercise-to-control-precocious-maturation-in-male-seabass-dicentrarchus-labrax
#6
Marco Graziano, Raul Benito, Josep V Planas, Arjan P Palstra
BACKGROUND: Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. In view of the known modulation of reproductive development by swimming exercise in other teleost species, we aimed at investigating the effects of sustained swimming on reproductive development in seabass males during the first year of life in order to determine if swimming could potentially reduce precocious sexual maturation...
April 12, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29617818/fshb-211-g-t-is-a-major-genetic-modulator-of-reproductive-physiology-and-health-in-childbearing-age-women
#7
Kristiina Rull, Marina Grigorova, Aivar Ehrenberg, Pille Vaas, Aire Sekavin, Diana Nõmmemees, Mart Adler, Ele Hanson, Peeter Juhanson, Maris Laan
STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associated with serum FSH, LH and anti-Müllerian hormone (AMH) levels in reproductive age women, their menstrual cycle parameters and risk of infertility? SUMMARY ANSWER: Only the FSHB -211 G>T variant was a major genetic determinant of serum gonadotropin levels in both, eumenorrheic healthy women and female infertility patients, and the T-allele carrier status was enriched among idiopathic infertility cases...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29609766/dienogest-suppresses-the-activation-of-primordial-follicles-and-preserves-the-primordial-follicle-stockpile-for-fertility-in-mice
#8
Luyi Zheng, Fuminori Kimura, Di Wu, Aina Morimune, Yoko Niwa, Shizuka Mita, Kentaro Takahashi, Takashi Murakami
The aim of the present study was to characterize the effect of long-term usage of dienogest, a fourth-generation progestin that possesses progestogen and anti-androgen activities, on the stockpile of oocytes and fertility after administration. Female ICR mice (100 days old) were divided into a dienogest group and a control group. The mice received 16 consecutive subcutaneous injections of 5 mg dienogest dissolved in corn oil or corn oil as a vehicle control every 4 days. The mice treated with dienogest had more total offspring and larger litter sizes after the final administration than the mice treated with the vehicle control...
April 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29595066/follicular-fluid-levels-of-anti-m%C3%A3-llerian-hormone-insulin-like-growth-factor-1-and-leptin-in-women-with-fertility-disorders
#9
Radek Kucera, Vaclav Babuska, Zdenka Ulcova-Gallova, Vlastimil Kulda, Ondrej Topolcan
Anti-Müllerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason...
March 29, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29580285/pioglitazone-is-effective-for-multiple-phenotyepes-of-the-zucker-fa-fa-rat-with-polycystc-ovary-morphology-and-insulin-resistance
#10
Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma, Tsuyoshi Saito
BACKGROUND: Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can be utilized as PCOS model rats without effects of hyperandrogenemia. PCOS patients are reported to have elevated levels of serum anti-Mullerian hormone (AMH), which has an inhibitory action on folliculogenesis, and low levels of serum adiponectin, which blocks apoptosis and induces biological effects in some tissues...
March 27, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29578420/-correlation-of-anti-mullerian-hormone-with-hormonal-and-ovarian-morphological-characteristics-in-patients-with-polycystic-ovary-syndrome-with-and-without-insulin-resistance
#11
E Asanidze, J Khristesashvili, L Pkhaladze, L Barbakadze
PCOS has a leading place in women's infertility. Based on the data of recent researches, Anti-Mullerian hormone (AMH) has been considered as one of the diagnostic criteria for PCOS. The aim of study was to determine the correlation of Anti-Mullerian hormone with hormonal and ovarian morphological characteristics in patients with PCOS, with and without insulin resistance. 110 women with diagnosis of PCOS were involved in the study. Patients were divided into two groups: PCOS patients with insulin resistance (60 women) and PCOS patients without insulin resistance (50 women)...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29560149/effect-of-metformin-on-the-anti-m%C3%A3-llerian-hormone-level-in-infertile-women-with-polycystic-ovarian-syndrome
#12
Fatemeh Foroozanfard, Mansooreh Samimi, Kosar Hosseini Almadani, Mojtaba Sehat
Background: Polycystic ovary syndrome (PCOS) is the major cause of anovulatory infertility in women. The level of serum Anti-Mullerian Hormone (AMH) in patients can be 2-3 times higher than in healthy women. The aim of this study was to assess the effect of metformin on AMH level in PCOS patients suffering from infertility. Methods: In this pre and post clinical trial, 30 infertile patients with PCOS were enrolled according to the Rotterdam criteria. The serum AMH level was recorded before and after 8 weeks of treatment with metformin (1500 mg daily)...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29546931/-granulosa-cell-ovarian-tumor-precocious-puberty-in-infant-less-than-1-year-of-age-case-report
#13
Patricia Lacourt, Julio Soto, Hana Rumié, Roger Gejman, Juan Carlos Pattillo, Cristián García, Hernán García
INTRODUCTION: Juvenile granulosa cell tumors (JGCT) are very rare, especially in infants under the age of one. The most frequent presentation is with signs of precocious puberty. OBJECTIVE: Present an in fant with peripheral precocious puberty, diagnosis of JGCT and follow up. CLINICAL CASE: 10-month-old female infant with thelarche, pubic hair and palpable abdominal mass accompanied with eleva ted levels of estradiol, very low gonadotrophins and images that show a very large ovarian mass...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29542837/testicular-development-in-male-lambs-prenatally-exposed-to-a-high-starch-diet
#14
Francesca Mossa, Daniela Bebbere, Antonello Ledda, Giovanni P Burrai, Imane Chebli, Elisabetta Antuofermo, Sergio Ledda, Antonello Cannas, Francesco Fancello, Alberto S Atzori
Maternal nutrition during critical gestation periods impacts on offspring in later life; effects of high-starch maternal diet on testicular development in lambs were addressed. Dairy ewes were fed diets providing either 27% (Starch, S) or 11% (Fiber, F) of starch from mating to lambing (∼147 days; S147, F147) or for the last 75 days of gestation (S75, F75). Testes of single male lambs were measured and then sampled for histological and gene expression analyses at selected ages. Testicular dimensions and weight were similar among groups, but the total area of seminiferous tubules increased with age and tended to be higher (P = 0...
March 15, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29540854/22q11-2-rearrangements-found-in-women-with-low-ovarian-reserve-and-premature-ovarian-insufficiency
#15
Sylvie Jaillard, Elena J Tucker, Linda Akloul, Marion Beaumont, Mathilde Domin, Laurent Pasquier, Guilhem Jouve, Sylvie Odent, Marc-Antoine Belaud-Rotureau, Célia Ravel
Ovarian reserve represents the number of available follicles/oocytes within ovaries and it can be assessed by follicle stimulating hormone levels, anti-Müllerian hormone levels, and/or antral follicle count determined by ultrasounds. A low ovarian reserve is defined by an abnormal ovarian reserve test. This condition can be considered premature if it occurs before the age of 40, leading to premature ovarian insufficiency. Despite the growing knowledge concerning the genetic basis of ovarian deficiency, the majority of cases remain without a genetic diagnosis...
March 14, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29540452/anti-m%C3%A3-llerian-hormone-overexpression-restricts-preantral-ovarian-follicle-survival
#16
Michael W Pankhurst, Rebecca L Kelley, Rachel L Sanders, Savana R Woodcock, Dorothy E Oorschot, Nicola J Batchelor
Anti-Müllerian hormone (AMH) is an ovarian regulator that affects folliculogenesis. AMH inhibits the developmental activation of the dormant primordial follicles and the oocyte within. In more mature follicles, AMH reduces granulosa cell sensitivity to follicle-stimulating hormone (FSH). We examined the effects of AMH overexpression on the stages of ovarian folliculogenesis, and the development of embryos, with a transgenic mouse that overexpresses human AMH in central nervous system neurons under the control of the mouse Thy1...
March 14, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29538744/in-vitro-formation-of-the-blood-testis-barrier-during-long-term-organotypic-culture-of-human-prepubertal-tissue-comparison-with-a-large-cohort-of-pre-peripubertal-boys
#17
F de Michele, J Poels, M G Giudice, F De Smedt, J Ambroise, M Vermeulen, D Gruson, C Wyns
STUDY QUESTION: How does the formation of the blood-testis barrier (BTB), as reflected by the expression of connexin 43 and claudin 11 proteins during the pubertal transition period, take place in vitro compared to samples from a large cohort of pre/peripubertal boys? SUMMARY ANSWER: The BTB connexin 43 and claudin 11 expression patterns appeared to be partially achieved in organotypic culture when compared to that in samples from 71 pre/peripubertal patients. WHAT IS KNOWN ALREADY: Although alterations in the protein expression patterns of the BTB, whose main components are connexin 43 and claudin 11, are known to be associated with impaired spermatogenesis in mice and adult men, there is a lack of knowledge on its formation in pre-peripubertal human tissue both in vitro and in vivo...
March 12, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29533759/anti-m%C3%A3-llerian-hormone-receptor-type-2-is-expressed-in-gonadotrophs-of-postpubertal-heifers-to-control-gonadotrophin-secretion
#18
Onalenna Kereilwe, Kiran Pandey, Vitaliano Borromeo, Hiroya Kadokawa
Preantral and small antral follicles may secret anti-Müllerian hormone (AMH) to control gonadotrophin secretion from ruminant gonadotrophs. The present study investigated whether the main receptor for AMH, AMH receptor type 2 (AMHR2), is expressed in gonadotrophs of postpubertal heifers to control gonadotrophin secretion. Expression of AMHR2 mRNA was detected in anterior pituitaries (APs) of postpubertal heifers using reverse transcription-polymerase chain reaction. An anti-AMHR2 chicken antibody was developed against the extracellular region near the N-terminus of bovine AMHR2...
March 14, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29533368/a-randomized-double-blind-placebo-controlled-trial-of-chinese-herbal-medicine-capsules-for-the-treatment-of-premature-ovarian-insufficiency
#19
Xiao-Jing Cao, Xuchun Huang, Jian Liu, Fei Ma, Yuyan Zeng, Changqian Chen, Ji-Ju Wang, Guangning Nie, Xiao-Yun Wang
OBJECTIVE: This study was conducted to evaluate the treatment effectiveness of Chinese herbal medicine capsules containing the Yangyin Shugan formula (YYSG) in premature ovarian insufficiency (POI). METHODS: One-hundred forty-six women with POI participated in this stratified, randomized, double-blind, placebo-controlled clinical trial. Participants in two groups (n = 73 in each)-the YYSG group and control group-underwent treatment for 12 weeks. Outcome measures included the Chinese version Menopause-Specific Quality of Life questionnaire (CMS), serum levels of basal follicle-stimulating hormone (bFSH), basal estradiol, and anti-Mullerian hormone (AMH), the antral follicle count (AFC), and ovarian peak systolic velocity (PSV; cm/s)...
March 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29533153/the-relationship-between-female-reproductive-functions-and-vitamin-d
#20
Sabriye Arslan, Yasemin Akdevelioğlu
Nonclassical target organs recently defined for vitamin D, a major regulator of calcium phosphorus homeostasis and bone health, include reproductive ones. This compilation study focuses on the potential effects of vitamin D on female reproductive functions. Vitamin D receptor enzymes that metabolize vitamin D are expressed in both central and peripheral reproductive organs. Most studies suggest that vitamin D may be directly or indirectly related to gonadal functions. Vitamin D's effects on reproductive functions may be indirectly related to diseases such as polycystic ovary syndrome (PCOS), uterine leiomyomas, and endometriosis...
March 13, 2018: Journal of the American College of Nutrition
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