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Schwann cell

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https://www.readbyqxmd.com/read/28735670/concomitant-malignant-pulmonary-peripheral-nerve-sheath-tumour-and-benign-cutaneous-peripheral-nerve-sheath-tumour-in-a-dog
#1
E O Silva, P F I Goiozo, L G Pereira, S A Headley, A F R L Bracarense
Peripheral nerve sheath tumours (PNSTs) are neoplastic growths derived from Schwann cells, perineural cells or both. Malignant PNSTs (MPNSTs) are uncommon in domestic animals. This report describes the concomitant occurrence of PNSTs in a 10-year-old female cocker spaniel with a clinical history of respiratory impairment. Grossly, there was a large infiltrative mass in the caudal lobe of the right lung; smaller nodules were observed in the other lobes of the right lung. Furthermore, a small encapsulated cutaneous nodule was observed on the left hindlimb...
July 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28735026/regulated-viral-bdnf-delivery-in-combination-with-schwann-cells-promotes-axonal-regeneration-through-capillary-alginate-hydrogels-after-spinal-cord-injury
#2
Shengwen Liu, Beatrice Sandner, Thomas Schackel, LaShae Nicholson, Abdelwahed Chtarto, Liliane Tenenbaum, Radhika Puttagunta, Rainer Müller, Norbert Weidner, Armin Blesch
Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an axonal bridge while physically directing regenerating axonal growth in a linear pattern. However, without an additional growth stimulus, bridging axons fail to extend into the distal host spinal cord. Here we examined whether a combinatory strategy would support regeneration of descending axons across a cervical (C5) lateral hemisection lesion in the rat spinal cord. Following spinal cord transections, Schwann cell (SC)-seeded alginate hydrogels were grafted to the lesion site and AAV5 expressing brain-derived neurotrophic factor (BDNF) under control of a tetracycline-regulated promoter was injected caudally...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28732247/repairing-sciatic-nerve-injury-with-an-epo-loaded-nerve-conduit-and-sandwiched-in-strategy-of-transplanting-mesenchymal-stem-cells
#3
Wei Zhang, Lihai Zhang, Jianheng Liu, Licheng Zhang, Jian Zhang, Peifu Tang
Transplantation of a biosynthetic nerve conduit carrying neuro-protective cytokines is promising for treating peripheral nerve injury. Here we developed a novel strategy for repairing sciatic nerve injury by EPO-loaded Chitosan nerve conduit (EPO/Chi) and sandwiched-in transplantation of mesenchymal stem cells (MSCs). Then, the beneficial effect of EPO/Chi + MSCs on nerve regeneration was also further investigated by in vitro cellular experiments. In vivo experiment showed that combination of EPO-loaded Chitosan nerve conduit with MSCs could significantly accelerate nerve healing and improve morphological repair...
July 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28730146/schwannoma-of-the-tongue-a-case-report-with-review-of-literature
#4
Eun-Young Lee, Jae-Jin Kim, Hyun Seok, Ja-Youn Lee
BACKGROUND: Schwannomas (or neurilemmomas) of the tongue are benign, usually solitary, encapsulated masses derived from Schwann cells. Clinical evidence indicates that schwannoma is painless and slow growing. In general, schwannoma is treated by surgical excision. Here, we describe a case of schwannoma of the tongue, include a review of the literature from 1955 to 2016, and provide data on age, gender, location, presenting symptoms, size, and treatment methods. CASE PRESENTATION: A 71-year-old female patient presented with a swelling at the base of the tongue of unknown duration...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28729624/taxanes-and-platinum-derivatives-impair-schwann-cells-via-distinct-mechanisms
#5
Satoshi Imai, Madoka Koyanagi, Ziauddin Azimi, Yui Nakazato, Mayuna Matsumoto, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Shuji Wakatsuki, Toshiyuki Araki, Shuji Kaneko, Takayuki Nakagawa, Kazuo Matsubara
Impairment of peripheral neurons by anti-cancer agents, including taxanes and platinum derivatives, has been considered to be a major cause of chemotherapy-induced peripheral neuropathy (CIPN), however, the precise underlying mechanisms are not fully understood. Here, we examined the direct effects of anti-cancer agents on Schwann cells. Exposure of primary cultured rat Schwann cells to paclitaxel (0.01 μM), cisplatin (1 μM), or oxaliplatin (3 μM) for 48 h induced cytotoxicity and reduced myelin basic protein expression at concentrations lower than those required to induce neurotoxicity in cultured rat dorsal root ganglion (DRG) neurons...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728859/-multiple-granular-cell-tumours-in-a-patient-with-noonan-s-syndrome-and-juvenile-myelomonocytic-leukaemia
#6
J Castagna, J Clerc, A-S Dupond, C Laresche
BACKGROUND: Granular cell tumour (GCT) is a rare form of tumour comprising Schwann cells. Herein, we report a case of a child presenting Noonan syndrome complicated by juvenile myelomonocytic leukaemia (JMML) and who also developed a multiple form of GCT. We discussed the molecular mechanisms that might account for this association. PATIENTS AND METHODS: A six-year-old boy with Noonan syndrome complicated by JMML presented three asymptomatic subcutaneous nodules on his back, forearm and neck...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28725423/dysphagia-caused-by-giant-schwannoma-of-the-supraglottic-oropharynx-a-case-report-and-review-of-the-literature
#7
Guojian Li, Xiao Xin, Xia Wang, Chongxi Ren
BACKGROUND: Schwannomas are benign, encapsulated, peripheral nerve tumours that arise from the Schwann cell. Approximately 25%-45% of schwannomas occur in the head and neck. The most common site is the parapharyngeal space of the neck. However, schwannoma of the supraglottic oropharynx is rare. CASE PRESENTATION: We report on a 35-year-old female who complained of progressive dysphagia, from whom a large schwannoma in the supraglottic oropharynx was excised through a transoral approach...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28722233/cooperative-interaction-of-hepatocyte-growth-factor-and-neuregulin-regulates-schwann-cell-migration-and-proliferation-through-grb2-associated-binder-2-in-peripheral-nerve-repair
#8
Yoon Kyoung Shin, So Young Jang, Seoug Hoon Yun, Yun Young Choi, Byeol-A Yoon, Young Rae Jo, So Young Park, Min Gyoung Pak, Joo In Park, Hwan Tae Park
The sequential reactive changes in Schwann cell phenotypes in transected peripheral nerves, including dedifferentiation, proliferation and migration, are essential for nerve repair. Even though the injury-induced migratory and proliferative behaviors of Schwann cells resemble epithelial and mesenchymal transition (EMT) in tumors, the molecular mechanisms underlying this phenotypic change of Schwann cells are still unclear. Here we show that the reactive Schwann cells exhibit migratory features dependent on the expression of a scaffolding oncoprotein Grb2-associated binder-2 (Gab2), which was transcriptionally induced by neuregulin 1-ErbB2 signaling following nerve injury...
July 19, 2017: Glia
https://www.readbyqxmd.com/read/28718615/development-of-nanofiber-sponges-containing-nerve-guidance-conduit-for-peripheral-nerve-regeneration-in-vivo
#9
Binbin Sun, Zi-Fei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo, Yinxian Yu
In the study of hollow nerve guidance conduit (NGC), the dispersion of regenerated axons always confused the researchers. To address this problem, filler-containing NGC was prepared, which showed better effect in the application of nerve tissue engineering. In this study, nanofiber sponges with abundant macro-pores, high porosity, and superior compressive strength were fabricated by electrospinning and freeze-drying. Poly (l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) nanofiber sponges were used as filler to prepare three-dimensional nanofiber sponges-containing (NS-containing) NGC...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28717876/structural-and-ultrastructural-changes-to-type-i-spiral-ganglion-neurons-and-schwann-cells-in-the-deafened-guinea-pig-cochlea
#10
Andrew K Wise, Remy Pujol, Thomas G Landry, James B Fallon, Robert K Shepherd
Sensorineural hearing loss is commonly caused by damage to cochlear sensory hair cells. Coinciding with hair cell degeneration, the peripheral fibres of type I spiral ganglion neurons (SGNs) that normally form synaptic connections with the inner hair cell gradually degenerate. We examined the time course of these degenerative changes in type I SGNs and their satellite Schwann cells at the ultrastructural level in guinea pigs at 2, 6, and 12 weeks following aminoglycoside-induced hearing loss. Degeneration of the peripheral fibres occurred prior to the degeneration of the type I SGN soma and was characterised by shrinkage of the fibre followed by retraction of the axoplasm, often leaving a normal myelin lumen devoid of axoplasmic content...
July 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28716587/botulinum-neurotoxin-a-promotes-functional-recovery-after-peripheral-nerve-injury-by-increasing-regeneration-of-myelinated-fibers
#11
Stefano Cobianchi, Jessica Jaramillo, Siro Luvisetto, Flaminia Pavone, Xavier Navarro
The injection of safe doses of botulinum neurotoxin A (BoNT/A) have been reported to be useful for the treatment of neuropathic pain, but it is still unknown how functional recovery is induced after peripheral nerve injury. We evaluated the effects of intranerve application of BoNT/A, on regeneration and sensorimotor functional recovery in partial and complete peripheral nerve injuries in the mouse. After sciatic nerve crush (SNC) and intranerve delivery of BoNT/A (15pg), axonal regeneration was measured by nerve pinch test at different days...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28714350/activation-and-expression-of-%C3%AE-calpain-in-dorsal-root-contributes-to-rtx-induced-mechanical-allodynia
#12
Xiao-Cui Yuan, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Xiao-Li Pan, Li-Xue Lin, Yan-Shen Liu, Wei Yu, Bo Tian, Xian-Fang Meng, Man Li
Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in a variety of pain models. Postherpetic neuralgia (Shingles) is a neuropathic pain conditioned with the presence of profound mechanical allodynia. Systemic injection of resiniferatoxin can reproduce the clinical symptoms of postherpetic neuralgia. In this study, we determined to study whether activation of calpain contributes to cleave the myelin basic protein of dorsal root and is involved in resiniferatoxin-induced mechanical allodynia of postherpetic neuralgia animal model...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28714175/schwann-cells-secrete-extracellular-vesicles-to-promote-and-maintain-the-proliferation-and-multipotency-of-hdpcs
#13
Ziyue Li, Yan Liang, Kuangwu Pan, Hui Li, Mei Yu, Weihua Guo, Guoqing Chen, Weidong Tian
OBJECTIVES: Schwann cells (SCs) are the principal glial cells in peripheral nerve system, involved in neuropathies with great regenerative potential. Dental pulp cells have been reported to maintain neurogenic potential. In contrast, the regulatory role of SCs on human dental pulp cells (hDPCs) development remains undefined. MATERIALS AND METHODS: SC secretion and SC-derived extracellular vesicles (EVs) were collected and used to treat hDPCs; and proliferation and multiple differentiation of hDPCs were detected after EVs treatments...
August 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28713821/comparative-analysis-of-the-cell-fates-of-induced-schwann-cells-from-subcutaneous-fat-tissue-and-na%C3%A3-ve-schwann-cells-in-the-sciatic-nerve-injury-model
#14
Mingzi Zhang, Mei Hua Jiang, Dae-Wook Kim, Woosung Ahn, Eunkyung Chung, Youngsook Son, Guangfan Chi
PURPOSE: The fate and function of the induced Schwann cells (iSCs) like cells from adipose tissue have not been critically evaluated in vivo after transplantation. The objective of this study is to compare the fate of iSCs with naïve SCs (nSCs) after transplantation into the lesion sites of sciatic nerve, respectively. METHODS: Adipose-derived stem cells from eGFP-expressing transgenic rat's subcutaneous fat were induced to iSCs in vitro. iSCs were injected to the sciatic nerve lesion area after crush injury and the cells fate was comparatively analyzed with that of nSCs from the same rat...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28713754/a-rare-report-of-two-cases-ancient-schwannoma-of-infratemporal-fossa-and-verocay-schwannoma-of-buccal-mucosa
#15
Prerna Piyush, Sujata Mohanty, Sujoy Ghosh, Sunita Gupta
Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. This paper comprises two case reports, both of which presented with an intraoral soft tissue swelling which turned out to be schwannoma of buccal mucosa and infratemporal fossa with extension into the oral cavity, respectively...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713262/effects-of-strength-training-and-anabolic-steroid-in-the-peripheral-nerve-and-skeletal-muscle-morphology-of-aged-rats
#16
Walter Krause Neto, Wellington de A Silva, Adriano P Ciena, Ricardo Aparecido Baptista Nucci, Carlos A Anaruma, Eliane F Gama
Thirty male 20-month-old Wistar rats were divided into groups: IC-initial control (n = 6), FC-final control (n = 6), AC-anabolic hormone control (n = 6), ST-strength trained (n = 6) and STA-strength trained with anabolic hormone (n = 6). All groups were submitted to adaptation, familiarization and maximum load carrying test (MLCT). Strength training (6-8×/session with loads of 50%-100% MLCT, 3×/week and pause of 120 s) was performed in ladder climbing (LC) for 15 weeks. The administration of testosterone propionate (TP) was performed 2×/week (10 mg/kg) in animals in the AC and STA groups...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28709021/architecting-the-myelin-landscape
#17
REVIEW
Lindsay A Osso, Jonah R Chan
Myelin increases the speed and efficiency of action potential propagation. Yet, not all axons are myelinated and some axons are discontinuously myelinated, prompting the question of how myelinating glia select axons for myelination. Whereas myelination by Schwann cells depends on axonal induction, oligodendrocytes can form myelin membrane in the absence of axons. However, oligodendrocytes alone cannot architect the complex myelination patterns of the central nervous system and recent advances have implicated axonal signaling in this process...
July 11, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28707715/myelinating-cocultures-of-rodent-stem-cell-line-derived-neurons-and-immortalized-schwann-cells
#18
Tomohiro Ishii, Emiko Kawakami, Kentaro Endo, Hidemi Misawa, Kazuhiko Watabe
Myelination is one of the most remarkable biological events in the neuron-glia interactions for the development of the mammalian nervous system. To elucidate molecular mechanisms of cell-to-cell interactions in myelin synthesis in vitro, establishment of the myelinating system in cocultures of continuous neuronal and glial cell lines are desirable. In the present study, we performed co-culture experiments using rat neural stem cell-derived neurons or mouse embryonic stem (ES) cell-derived motoneurons with immortalized rat IFRS1 Schwann cells to establish myelinating cultures between these cell lines...
July 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28704293/analysis-of-neural-crest-cells-from-charcot-marie-tooth-disease-patients-demonstrates-disease-relevant-molecular-signature
#19
Fukiko Kitani-Morii, Keiko Imamura, Takayuki Kondo, Ryo Ohara, Takako Enami, Ran Shibukawa, Takuya Yamamoto, Kazuya Sekiguchi, Junya Toguchida, Toshiki Mizuno, Masanori Nakagawa, Haruhisa Inoue
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy. The majority of CMT is demyelinating type (demyelinating CMT) caused by Schwann cell involvement. Although a large number of genes responsible for demyelinating CMT have been found, the common molecular target of the pathophysiology caused by these different genes in demyelinating CMT is still unknown. We generated induced pluripotent stem cells (iPSCs) from healthy controls and patients with demyelinating CMT caused by duplication in peripheral myelin protein 22 kDa (PMP22) or point mutations in myelin protein zero (MPZ) or early growth response 2 (EGR2)...
July 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28700706/spatial-distribution-of-cannabinoid-receptor-type-1-cb1-in-normal-canine-central-and-peripheral-nervous-system
#20
Jessica Freundt-Revilla, Kristel Kegler, Wolfgang Baumgärtner, Andrea Tipold
The endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and peripheral nervous systems (PNS) in mammalians and is involved in neuromodulatory functions. Since endocannabinoids were shown to be elevated in cerebrospinal fluid of epileptic dogs, knowledge about the species specific CB receptor expression in the nervous system is required. Therefore, we assessed the spatial distribution of CB1 receptors in the normal canine CNS and PNS...
2017: PloS One
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