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Barth study

P Metais, P Clavert, J Barth, P Boileau, R Broszka, G Nourissat, J Leuzinger, G Walch, L Lafosse
BACKGROUND: The Latarjet-Patte procedure consisting in transfer and screw fixation of the coracoid process to the anterior glenoid is a treatment of reference for anterior shoulder instability. Over time, surgical innovations translated into a number of improvements and, in late 2003, an arthroscopically assisted variant of the procedure was described. OBJECTIVE: To evaluate and compare clinical outcomes of the modified Latarjet-Patte procedure performed by open surgery, arthroscopy with screw fixation, or arthroscopy with endobutton fixation...
October 19, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E Wanker
Interaction mapping is a powerful strategy to elucidate the biological function of protein assemblies and their regulators. Here, we report the generation of a quantitative interaction network, directly linking 14 human proteins to the AAA+ ATPase p97, an essential hexameric protein with multiple cellular functions. We show that the high-affinity interacting protein ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL heterotetramers. High-resolution structural and biochemical studies indicate that an extended UBX domain (eUBX) in ASPL is critical for p97 hexamer disassembly and facilitates the assembly of p97:ASPL heterotetramers...
October 20, 2016: Nature Communications
Ingo Fietze, Charlotte Barthe, Matthias Hölzl, Martin Glos, Sandra Zimmermann, Ralf Bauer-Diefenbach, Thomas Penzel
INTRODUCTION: Noise is one of the factors that can seriously disturb sleep, and sound volume is an important factor in this context. One strategy involves avoiding exposure to sounds in the night, while entail the minimization of background noise in a bedroom. The goal of this study was to investigate the effect of systematic sound attenuation on nocturnal sleep by influencing sound volume and reverberation within the context of room acoustics. MATERIALS AND METHODS: On this basis, we designed a randomized, controlled crossover trial investigating 24 healthy sleepers (15 men and 9 women, aged 24...
September 2016: Noise & Health
Angélica Adam Barth, Bruna Dorfey Weigel, Claus Dieter Dummer, Kelly Campara Machado, Taís Montagner Tisott
OBJECTIVE: To identify and stratify the main stressors for the relatives of patients admitted to the adult intensive care unit of a teaching hospital. METHODS: Cross-sectional descriptive study conducted with relatives of patients admitted to an intensive care unit from April to October 2014. The following materials were used: a questionnaire containing identification information and demographic data of the relatives, clinical data of the patients, and 25 stressors adapted from the Intensive Care Unit Environmental Stressor Scale...
September 2016: Revista Brasileira de Terapia Intensiva
Nicolas P F Barthes, Krishna Gavvala, Dominique Bonhomme, Anne Sophie Dabert-Gay, Delphine Debayle, Yves Mély, Benoît Y Michel, Alain Burger
We report the synthesis and site-specific incorporation in oligodeoxynucleotides (ODNs) of an emissive deoxyuridine analog electronically conjugated on its C5-position with a 3-methoxychromone moiety acting as a fluorophore. When incorporated in ODNs, this fluorescent deoxyuridine analog exhibits remarkable photostability and good quantum yield. This deoxyuridine analog also displays a mega-Stokes shift, which allows its use as an efficient donor for FRET-based studies when paired with the yellow emissive ‎indocarbocyanine Cy3 acceptor...
October 10, 2016: Journal of Organic Chemistry
P Clavert, G Koch, L Neyton, P Metais, J Barth, G Walch, L Lafosse
BACKGROUND: Standard radiography with an antero-posterior view and Bernageau's glenoid profile view is the method most widely reported in the literature to assess coracoid bone block position and fusion. OBJECTIVE: The aim of this cadaver study was to determine whether the antero-posterior and Bernageau's radiographs provide a reliable and reproducible evaluation of the position of a coracoid bone block and its fixation screws. METHOD: An isolated scapula showing no evidence of osteoarthritis or other abnormalities was used...
October 4, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
C S Hakkers, J E Arends, R E Barth, S Du Plessis, A I M Hoepelman, M Vink
HIV-associated neurocognitive disorder (HAND) is a frequently occurring comorbidity of HIV infection. Evidence suggests this condition starts subclinical before a progression to a symptomatic stage. Blood oxygenated level dependent (BOLD) fMRI has shown to be a sensitive tool to detect abnormal brain function in an early stage and might therefore be useful to evaluate the effect of HIV infection on brain function. An extensive literature search was performed in June 2015. Eligibility criteria for included studies were as follows: (1) conducting with HIV-positive patients, (2) using BOLD fMRI, and (3) including a HIV-negative control group...
October 7, 2016: Journal of Neurovirology
Anelise Barth, Natália Brucker, Angela M Moro, Sabrina Nascimento, Gabriela Goethel, Caroline Souto, Rafael Fracasso, Elisa Sauer, Louise Altknecht, Bárbara da Costa, Marta Duarte, Camila B Menezes, Tiana Tasca, Marcelo D Arbo, Solange Cristina Garcia
Environmental exposure to pollutants, especially polycyclic aromatic hydrocarbons (PAHs), could lead to carcinogenesis development. However, there is a gap on the mechanisms involved in this effect. Therefore, the aim of this study was to investigate the potential relationship between exposure to environmental air pollution and inflammation process in DNA damage in taxi drivers. This study included 45 taxi drivers and 40 controls; non-smokers composed both groups. Biological monitoring was performed through quantification of urinary 1-hydroxypyrene (1-OHP)...
October 8, 2016: Environmental Science and Pollution Research International
Claudia Barth, Christopher J Steele, Karsten Mueller, Vivien P Rekkas, Katrin Arélin, Andre Pampel, Inga Burmann, Jürgen Kratzsch, Arno Villringer, Julia Sacher
Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impact of subtle sex-hormonal fluctuations on human hippocampal structure in health is unclear. We tested the feasibility of longitudinal neuroimaging in conjunction with rigorous menstrual cycle monitoring to evaluate potential changes in hippocampal microstructure associated with physiological sex-hormonal changes...
October 7, 2016: Scientific Reports
Kenneth Barth, Caroline Attardo Genco
The NFκB and MAPK signaling pathways are critical components of innate immunity that orchestrate appropriate immune responses to control and eradicate pathogens. Their activation results in the induction of proinflammatory mediators, such as TNFα a potent bioactive molecule commonly secreted by recruited inflammatory cells, allowing for paracrine signaling at the site of an infection. In this study we identified a novel mechanism by which the opportunistic pathogen Porphyromonas gingivalis dampens innate immune responses by disruption of kinase signaling and degradation of inflammatory mediators...
October 4, 2016: Scientific Reports
Sergey V Brodsky, Rolf F Barth, Xiaokui Mo, Vedat Yildiz, Patricia Allenby, Iouri Ivanov, Stephen Moore, Charles L Hitchcock, Stephen Smith, Taha Sachak, Keluo Yao, Matthew Ball, Kelly Rosborough, Zachary Olson, Micah Kiehl, Navin Muni, Renu Virmani
BACKGROUND AND AIMS: Morbid obesity generally has been associated with higher morbidity and mortality for a variety of diseases. However, a number of exceptions to this have been reported and referred to as the "obesity paradox." The purpose of the present study was to obtain objective data on aortic atherosclerosis and its relationship to body mass index (BMI, kg/m(2)), based on autopsy findings in a large cohort of overweight and obese decedents. METHODS: Decedents were ≥18 years who had autopsies between 2003 and 2014, a subset of whom were morbidly obese (BMI≥40)...
September 13, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Fernanda de Lima Moreira, Maísa D Habenschus, Thiago Barth, Lucas M M Marques, Alan Cesar Pilon, Vanderlan da Silva Bolzani, Ricardo Vessecchi, Norberto P Lopes, Anderson R M de Oliveira
Piperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented...
September 29, 2016: Scientific Reports
Kiyoshi Ichihara, Yesim Ozarda, Julian H Barth, George Klee, Yoshihisa Shimizu, Liangyu Xia, Mariza Hoffmann, Swarup Shah, Tandi Matsha, Janette Wassung, Francois Smit, Anna Ruzhanskaya, Joely Straseski, Daniel N Bustos, Shogo Kimura, Aki Takahashi
OBJECTIVES: The intent of this study, based on a global multicenter study of reference values (RVs) for serum analytes was to explore biological sources of variation (SVs) of the RVs among 12 countries around the world. METHODS: As described in the first part of this paper, RVs of 50 major serum analytes from 13,396 healthy individuals living in 12 countries were obtained. Analyzed in this study were 23 clinical chemistry analytes and 8 analytes measured by immunoturbidimetry...
September 22, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kiyoshi Ichihara, Yesim Ozarda, Julian H Barth, George Klee, Ling Qiu, Rajiv Erasmus, Anwar Borai, Svetlana Evgina, Tester Ashavaid, Dilshad Khan, Laura Schreier, Reynan Rolle, Yoshihisa Shimizu, Shogo Kimura, Reo Kawano, David Armbruster, Kazuo Mori, Binod K Yadav
OBJECTIVES: The IFCC Committee on Reference Intervals and Decision Limits coordinated a global multicenter study on reference values (RVs) to explore rational and harmonizable procedures for derivation of reference intervals (RIs) and investigate the feasibility of sharing RIs through evaluation of sources of variation of RVs on a global scale. METHODS: For the common protocol, rather lenient criteria for reference individuals were adopted to facilitate harmonized recruitment with planned use of the latent abnormal values exclusion (LAVE) method...
September 22, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kara Marie Hessel, Erich Wessel, Anthony Olinger, Barth W Wright
BACKGROUND: This study aimed to identify the Anterior and Posterior Extralaryngeal branches (AELB, PELB) of the Recurrent Laryngeal Nerve (RLN), measure these branches when present, and determine relationships between gender, sidedness and neck length. MATERIALS AND METHODS: Dissection was completed to level of the thyroid on 45 cadavers. The course of the RLN was then traced superiorly from its entry into the neck. Careful reflection of the thyroid and dissection of the lateral thyroid ligament permitted visualization of the full course of the nerve...
September 26, 2016: Folia Morphologica (Warsz)
Katharina Martini, Borna K Barth, Kai Higashigaito, Stephan Baumueller, Hatem Alkadhi, Thomas Frauenfelder
To determine the lowest CT radiation dose-level at maintained image-quality and high sensitivity for detection of pulmonary-nodules in obesity. Single-energy CT with tin-filtration was performed in a chest-phantom with solid pulmonary-nodules simulating over-weight and obesity. CTDIvol of the standard-protocol was 0.41 mGy, subsequent scans were obtained at 1/2 and 1/4 dose-levels. Images were reconstructed using FBP and advanced-modeled iterative reconstruction (ADMIRE). Noise, image-quality, and sensitivity for nodule-detection were assessed...
August 2, 2016: Current Problems in Diagnostic Radiology
David Kenkel, Borna K Barth, Marco Piccirelli, Lukas Filli, Tim Finkenstädt, Cäcilia S Reiner, Andreas Boss
OBJECTIVES: The aims of this study were to implement a protocol for simultaneous multislice (SMS) accelerated diffusion-weighted imaging (DWI) of the kidneys and to perform a systematic analysis of image quality of the data sets. MATERIALS AND METHODS: Ten healthy subjects and 5 patients with renal masses underwent DWI of the kidney in this prospective institutional review board-approved study on a 3 T magnetic resonance scanner. Simultaneous multislice DWI echo-planar sequences (acceleration factors [AFs] 2 and 3) were compared with conventional echo-planar DWI as reference standard for each acquisition scheme...
September 22, 2016: Investigative Radiology
Barth B Riley, Tonda L Hughes, Sharon C Wilsnack, Timothy P Johnson, Perry Benson, Frances Aranda
BACKGROUND: Although sexual minority women (SMW) are at increased risk of hazardous drinking (HD), efforts to validate HD measures have yet to focus on this population. OBJECTIVES: Validation of a 13-item Hazardous Drinking Index (HDI) in a large sample of SMW. METHODS: Data were from 700 adult SMW (age 18-82) enrolled in the Chicago Health and Life Experiences of Women study. Criterion measures included counts of depressive symptoms and post-traumatic stress disorder (PTSD) symptoms, average daily and 30-day ethanol consumption, risky sexual behavior, and Diagnostic and Statistical Manual (DSM-IV) measures of alcohol abuse/dependence...
September 23, 2016: Substance Use & Misuse
Karsten Hamm, Michael Zacher, Martina Hautmann, Frank Gietzen, Philipp Halbfass, Sebastian Kerber, Anno Diegeler, Bernhard Schieffer, Sebastian Barth
OBJECTIVES: We sought to determine the effects of experience on the Mitraclip(®) procedure steps as well as procedure safety and functional results. BACKGROUND: MR has proven deleterious in heart failure. Mitraclip(®) therapy evolved an important option in patients with severely reduced left ventricular function (LVEF). METHODS: Between 2011 and 2016, 126 consecutive patients were grouped in three groups and investigated in a prospective observational study...
September 21, 2016: Catheterization and Cardiovascular Interventions
Juliane Schmidt, Ren Wei, Thorsten Oeser, Matheus Regis Belisário-Ferrari, Markus Barth, Johannes Then, Wolfgang Zimmermann
The enzymatic degradation of polyethylene terephthalate (PET) occurs at mild reaction conditions and may find applications in environmentally friendly plastic waste recycling processes. The hydrolytic activity of the homologous polyester hydrolases LC cutinase (LCC) from a compost metagenome and TfCut2 from Thermobifida fusca KW3 against PET films was strongly influenced by the reaction medium buffers tris(hydroxymethyl)aminomethane (Tris), 3-(N-morpholino)propanesulfonic acid (MOPS), and sodium phosphate. LCC showed the highest initial hydrolysis rate of PET films in 0...
September 2016: FEBS Open Bio
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