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https://www.readbyqxmd.com/read/28626905/genome-architecture-enables-local-adaptation-of-atlantic-cod-despite-high-connectivity
#1
Julia M I Barth, Paul R Berg, Per R Jonsson, Sara Bonanomi, Hanna Corell, Jakob Hemmer-Hansen, Kjetill S Jakobsen, Kerstin Johannesson, Per Erik Jorde, Halvor Knutsen, Per-Olav Moksnes, Bastiaan Star, Nils Chr Stenseth, Henrik Svedäng, Sissel Jentoft, Carl André
Adaptation to local conditions is a fundamental process in evolution; however, mechanisms maintaining local adaptation despite high gene flow are still poorly understood. Marine ecosystems provide a wide array of diverse habitats that frequently promote ecological adaptation even in species characterized by strong levels of gene flow. As one example, populations of the marine fish Atlantic cod (Gadus morhua) are highly connected due to immense dispersal capabilities but nevertheless show local adaptation in several key traits...
June 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28623277/in-vivo-quantification-of-placental-insufficiency-by-bold-mri-a-human-study
#2
Jie Luo, Esra Abaci Turk, Carolina Bibbo, Borjan Gagoski, Drucilla J Roberts, Mark Vangel, Clare M Tempany-Afdhal, Carol Barnewolt, Judy Estroff, Arvind Palanisamy, William H Barth, Chloe Zera, Norberto Malpica, Polina Golland, Elfar Adalsteinsson, Julian N Robinson, Patricia Ellen Grant
Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620209/using-variable-importance-measures-to-identify-a-small-set-of-snps-to-predict-heading-date-in-perennial-ryegrass
#3
Stephen L Byrne, Patrick Conaghan, Susanne Barth, Sai Krishna Arojju, Michael Casler, Thibauld Michel, Janaki Velmurugan, Dan Milbourne
Prior knowledge on heading date enables the selection of parents of synthetic cultivars that are well matched with respect to time of heading, which is essential to ensure plants put together will cross pollinate. Heading date of individual plants can be determined via direct phenotyping, which has a time and labour cost. It can also be inferred from family means, although the spread in days to heading within families demands roguing in first generation synthetics. Another option is to predict heading date from molecular markers...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619753/inhibition-of-hsp90-suppresses-pi3k-akt-mtor-signaling-and-has-antitumor-activity-in-burkitt-lymphoma
#4
Lisa Giulino-Roth, Herman J Van Besien, Tanner Dalton, Jennifer E Totonchy, Anna Rodina, Tony Taldone, Alexander Bolaender, Hediye Erdjument-Bromage, Jouliana Sadek, Amy Chadburn, Matthew J Barth, Filemon S Dela Cruz, Allison Rainey, Andrew L Kung, Gabriela Chiosis, Ethel Cesarman
Heat shock protein 90 (Hsp90) is a molecular chaperone that protects proteins, including oncogenic signaling complexes, from proteolytic degradation.  PU-H71 is a next-generation Hsp90 inhibitor that preferentially targets the functionally distinct pool of Hsp90 present in tumor cells.  Tumors that are driven by the MYC oncoprotein may be particularly sensitive to PU-H71 due to the essential role of Hsp90 in the epichaperome which maintains the malignant phenotype in the setting of MYC.  Burkitt lymphoma (BL) is an aggressive B-cell lymphoma characterized by MYC dysregulation...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28609364/therapeutic-endoscopic-retrograde-cholangiopancreatography-in-pediatric-patients-with-acute-recurrent-and-chronic-pancreatitis-data-from-the-insppire-international-study-group-of-pediatric-pancreatitis-in-search-for-a-cure-study
#5
David M Troendle, Douglas S Fishman, Bradley A Barth, Matthew J Giefer, Tom K Lin, Quin Y Liu, Maisam Abu-El-Haija, Melena D Bellin, Peter R Durie, Steven D Freedman, Cheryl Gariepy, Tanja Gonska, Melvin B Heyman, Ryan Himes, Sohail Z Husain, Soma Kumar, Mark E Lowe, Veronique D Morinville, Chee Y Ooi, Joseph Palermo, John F Pohl, Sarah Jane Schwarzenberg, Steven Werlin, Michael Wilschanski, M Bridget Zimmerman, Aliye Uc
OBJECTIVE: The aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP). METHODS: From August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment...
July 2017: Pancreas
https://www.readbyqxmd.com/read/28605698/intuitive-proportion-judgment-in-number-line-estimation-converging-evidence-from-multiple-tasks
#6
Emily Slusser, Hilary Barth
How children's understanding of numerical magnitudes changes over the course of development remains a key question in the study of numerical cognition. In an ongoing debate about the source of developmental change, some argue that children maintain and access different mental representations of number, with evidence coming largely from common number-line estimation tasks. In contrast, others argue that a theoretical framework based on psychophysical models of proportion estimation accounts for typical performance on these tasks...
June 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28600715/partition-dependence-in-consumer-choice-perceptual-groupings-do-not-reliably-shape-decisions
#7
Sheri Reichelson, Alexandra Zax, Ilona Bass, Andrea L Patalano, Hilary C Barth
The partitioning of options into arbitrary categories has been shown to influence decisions about allocating choices or resources among those options; this phenomenon is called partition dependence. While we do not call into question the validity of the partition dependence phenomenon in the present work, we do examine the robustness of one of the experimental paradigms reported by Fox, Ratner, and Lieb (Journal of Experimental Psychology: General, 134, 538-551, 2005, Study 4). In three experiments (N = 300) conducted here, participants chose from a menu of perceptually partitioned options (varieties of candy distributed across bowls)...
June 9, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28588537/using-cnn-features-to-better-understand-what-makes-visual-artworks-special
#8
Anselm Brachmann, Erhardt Barth, Christoph Redies
One of the goal of computational aesthetics is to understand what is special about visual artworks. By analyzing image statistics, contemporary methods in computer vision enable researchers to identify properties that distinguish artworks from other (non-art) types of images. Such knowledge will eventually allow inferences with regard to the possible neural mechanisms that underlie aesthetic perception in the human visual system. In the present study, we define measures that capture variances of features of a well-established Convolutional Neural Network (CNN), which was trained on millions of images to recognize objects...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28579420/dynamic-processes-in-biological-membrane-mimics-revealed-by-quasielastic-neutron-scattering
#9
REVIEW
Lisa Lautner, Kristyna Pluhackova, Nicolai K H Barth, Tilo Seydel, Wiebke Lohstroh, Rainer A Böckmann, Tobias Unruh
Neutron scattering is a powerful tool to study relaxation processes in biological membrane mimics in space and time. Combining different inelastic and quasielastic neutron scattering techniques, a large dynamic range can be covered: from atomic to mesoscopic lengths and from femto- to some hundreds of nanoseconds in time. This allows studies on e.g. the diffusion of lipids, the membrane undulation motions, the dispersion of sound waves in membranes as well as the mutual interactions of membrane constituents such as lipids, proteins, and additives...
June 1, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28568427/left-ventricular-ejection-fraction-of%C3%A2-%C3%A2-20-too-bad-for-mitraclip%C3%A2
#10
Sebastian Barth, Martina B Hautmann, Sebastian Kerber, Frank Gietzen, Wilko Reents, Michael Zacher, Philipp Halbfass, Daniel P Griese, Bernhard Schieffer, Karsten Hamm
OBJECTIVES: This study sought to investigate whether the percutaneous mitral regurgitation (MR) reduction with the MitraClip® system in end-stage heart failure patients with a left ventricular ejection fraction (LVEF) of <20% also effects beneficial outcome or whether the underlying myogenic problem is leading and therefore of prognostic relevance. BACKROUND: The interventional treatment of functional mitral regurgitation (FMR) with the MitraClip(®) system could improve the clinical and hemodynamic outcome in patients with severely impaired left ventricular function...
June 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28562753/group-b-streptococcus-detection-in-pregnant-women-via-culture-and-pcr-methods
#11
Cláudia Wollheim, Rosa Dea Sperhacke, Sabrina Kahler Ribeiro Fontana, Andréa Cristina Vanni, Sérgio Kakuta Kato, Patricia Regina de Araújo, Afonso Luis Barth, José Mauro Madi
INTRODUCTION: Group B Streptococcus (GBS), a source of neonatal infection, colonizes the gastrointestinal and genitourinary tracts of pregnant women. Routine screening for maternal GBS in late pregnancy and consequent intrapartum antibiotic prophylaxis have reduced the incidence of early-onset GBS neonatal infection. The aim of this study was to evaluate the performance of PCR, compared to culture (gold standard), in GBS colonization screening of pregnant women, and to establish the prevalence of GBS colonization among this population...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28562498/development-and-feasibility-of-an-academic-detailing-intervention-to-improve-prescription-drug-monitoring-program-use-among-physicians
#12
Kelly S Barth, Sarah Ball, Rachel S Adams, Ruslan Nikitin, Nikki R Wooten, Zaina P Qureshi, Mary J Larson
INTRODUCTION: South Carolina (SC) ranks 10th in opioid prescriptions per capita-33% higher than the national average. SC is also home to a large military and veteran population, and prescription opioid use for chronic pain is alarmingly common among veterans, especially those returning from Afghanistan and Iraq. This article describes the background and development of an academic detailing (AD) educational intervention to improve use of a Prescription Drug Monitoring Program among SC physicians who serve military members and veterans...
April 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28555403/dissemination-of-bla-oxa-370-gene-among-several-enterobacteriaceae-species-in-brazil
#13
C M Magagnin, F P Rozales, L Antochevis, L S Nunes, A S Martins, A L Barth, J M Sampaio, A P Zavascki
OXA-370 is a recently described OXA-48 variant that has only been described in a few Enterobacter spp. and Klebsiella pneumoniae isolates. The purpose of this study is to assess the prevalence of OXA-370-producing isolates in carbapenem-nonsusceptible Enterobacteriaceae recovered from 28 hospitals from Brazil. Real-time PCR was used to determine the presence of bla NDM-1, bla KPC-2, bla VIM-type, bla GES-type, bla OXA-48-like, and bla IMP-type genes. A total of 4,451 Enterobacteriaceae were screened. The gene bla OXA-48-like was detected in 74 (2...
May 30, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28554038/polymerization-kinetics-of-a-mixture-of-lipiodol-and-glubran-2-cyanoacrylate-glue-upon-contact-with-a-proteinaceous-solution
#14
Y J Li, D Barthès-Biesel, A-V Salsac
The Glubran 2 cyanoacrylate glue is a liquid embolic agent used to block blood vessels endovascularly. Typically mixed with an iodized oil (Lipiodol) for visualization under X-ray, it polymerizes when in contact with blood and tissues owing to the presence of ions and proteins. The objective of the study is to determine the influence of plasma proteins in the polymerization reaction. A triggering solution containing bovine serum albumin (BSA) and the main blood ions is used as a model of plasma. The polymerization kinetics of Glubran 2-Lipiodol mixtures is measured upon aspiration in a capillary tube and contact with the proteinaceous solution...
May 17, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28550041/central-nervous-system-involvement-in-acute-lymphoblastic-leukemia-is-mediated-by-vascular-endothelial-growth-factor
#15
Vera Münch, Luca Trentin, Julia Herzig, Salih Demir, Felix Seyfried, Johann M Kraus, Hans A Kestler, Rolf Köhler, Thomas F E Barth, Geertruy Te Kronnie, Klaus-Michael Debatin, Lüder H Meyer
In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major clinical concern. Despite non-detectable CNS leukemia in many cases, prophylactic CNS-directed conventional intrathecal chemotherapy is required for relapse free survival indicating subclinical CNS manifestation in most patients. However, CNS-directed therapy is associated with long-term sequelae including neurocognitive deficits and secondary neoplasms. Therefore, molecular mechanisms and pathways mediating leukemia cell entry into the CNS need to be understood in order to identify targets for prophylactic and therapeutic interventions and develop alternative CNS-directed treatment strategies...
May 26, 2017: Blood
https://www.readbyqxmd.com/read/28541507/current-management-and-clinical-outcomes-for-catheter-ablation-of-atrioventricular-nodal-re-entrant-tachycardia
#16
Jonathan Chrispin, Satish Misra, Joseph E Marine, John Rickard, Andreas Barth, Aravindan Kolandaivelu, Hiroshi Ashikaga, Harikrishna Tandri, David D Spragg, Jane Crosson, Ronald D Berger, Gordon Tomaselli, Hugh Calkins, Sunil K Sinha
Aims: Historical studies of ablation of atrioventricular nodal re-entrant tachycardia (AVNRT) have shown high long-term success rates and low complication rates. The potential impact of several recent practice trends has not been described. This study aims to characterize recent clinical practice trends in AVNRT ablation and their associated success rates and complications. Methods and results: Patients undergoing initial ablation of AVNRT between 1 July 2005 and 30 June 2015 were included in this study...
May 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28538780/anatomic-pulmonary-resection-via-video-assisted-thoracic-surgery-analysis-of-117-cases-at-a-referral-center-in-brazil
#17
Stephan Adamour Soder, Frederico Barth, Fabiola Adelia Perin, José Carlos Felicetti, José de Jesus Peixoto Camargo, Spencer Marcantônio Camargo
Objective: To describe our experience with video-assisted thoracic surgery (VATS) for anatomic pulmonary resection at a referral center for thoracic surgery in Brazil. Methods: All patients who underwent anatomic pulmonary resection by VATS between 2010 and 2015 were included. Clinical and pathological data, as well as postoperative complications, were analyzed. Results: A total of 117 pulmonary resections by VATS were performed, of which 98 were lobectomies and 19 were anatomic segmentectomies...
March 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28538444/changes-in-cervical-alignment-after-multilevel-schwab-grade-ii-thoracolumbar-osteotomies-for-adult-spinal-deformity
#18
George M Ghobrial, Nathan H Lebwohl, Barth A Green, Joseph P Gjolaj
STUDY DESIGN: Retrospective Cohort OBJECTIVE.: To describe changes in cervical alignment(CA) and deformity (CD) after multilevel Schwab Grade II Osteotomies for adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Reciprocal cervical and global changes after ASD surgery have not been previous described in the setting of multilevel osteotomy. METHODS: Patients with long-segment (> 5 levels) fusion and osteotomy for ASD were radiographically evaluated...
May 19, 2017: Spine
https://www.readbyqxmd.com/read/28537262/induction-of-resident-memory-t-cells-enhances-the-efficacy-of-cancer-vaccine
#19
Mevyn Nizard, Hélène Roussel, Mariana O Diniz, Soumaya Karaki, Thi Tran, Thibault Voron, Estelle Dransart, Federico Sandoval, Marc Riquet, Bastien Rance, Elie Marcheteau, Elizabeth Fabre, Marion Mandavit, Magali Terme, Charlotte Blanc, Jean-Baptiste Escudie, Laure Gibault, Françoise Le Pimpec Barthes, Clemence Granier, Luis C S Ferreira, Cecile Badoual, Ludger Johannes, Eric Tartour
Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534152/cerebrospinal-fluid-dissemination-of-high-grade-gliomas-following-boron-neutron-capture-therapy-occurs-more-frequently-in-the-small-cell-subtype-of-idh1-r132h-mutation-negative-glioblastoma
#20
Natsuko Kondo, Rolf F Barth, Shin-Ichi Miyatake, Shinji Kawabata, Minoru Suzuki, Koji Ono, Norman L Lehman
We have used boron neutron capture therapy (BNCT) to treat patients in Japan with newly diagnosed or recurrent high-grade gliomas and have observed a significant increase in median survival time following BNCT. Although cerebrospinal fluid dissemination (CSFD) is not usually seen with the current standard therapy of patients with glioblastoma (GBM), here we report that subarachnoid or intraventricular CSFD was the most frequent cause of death for a cohort of our patients with high-grade gliomas who had been treated with BNCT...
May 22, 2017: Journal of Neuro-oncology
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